Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | (+)-schisandrin B | multiple interactions | EXP | | 6480464 | schizandrin B inhibits the reaction [Carbon Tetrachloride results in increased expression of BHLHA15 mRNA] | CTD | PMID:31150632 | 1,2-dimethylhydrazine | increases expression | ISO | Bhlha15 (Mus musculus) | 6480464 | 1 and 2-Dimethylhydrazine results in increased expression of BHLHA15 mRNA | CTD | PMID:22206623 | 17beta-estradiol | increases expression | ISO | BHLHA15 (Homo sapiens) | 6480464 | Estradiol results in increased expression of BHLHA15 mRNA | CTD | PMID:23019147 | 17beta-estradiol | decreases expression | EXP | | 6480464 | Estradiol results in decreased expression of BHLHA15 mRNA | CTD | PMID:32145629 | 2,2',4,4'-Tetrabromodiphenyl ether | affects expression | ISO | Bhlha15 (Mus musculus) | 6480464 | 2 more ... | CTD | PMID:30294300 | 2,3,7,8-tetrachlorodibenzodioxine | multiple interactions | ISO | Bhlha15 (Mus musculus) | 6480464 | AHR protein affects the reaction [Tetrachlorodibenzodioxin results in increased expression of BHLHA15 mRNA] | CTD | PMID:16891777 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | EXP | | 6480464 | Tetrachlorodibenzodioxin affects the expression of BHLHA15 mRNA | CTD | PMID:32109520 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | Bhlha15 (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin affects the expression of BHLHA15 mRNA | CTD | PMID:21570461 | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | ISO | Bhlha15 (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin results in increased expression of BHLHA15 mRNA | CTD | PMID:16891777 | 2,4,6-trinitrotoluene | affects expression | EXP | | 6480464 | Trinitrotoluene affects the expression of BHLHA15 mRNA | CTD | PMID:21346803 | 2-hydroxypropanoic acid | decreases expression | ISO | BHLHA15 (Homo sapiens) | 6480464 | Lactic Acid results in decreased expression of BHLHA15 mRNA | CTD | PMID:30851411 | 4,4'-sulfonyldiphenol | affects methylation | ISO | Bhlha15 (Mus musculus) | 6480464 | bisphenol S affects the methylation of BHLHA15 gene | CTD | PMID:31683443 | 6-propyl-2-thiouracil | increases expression | EXP | | 6480464 | Propylthiouracil results in increased expression of BHLHA15 mRNA | CTD | PMID:24780913 | acetamide | increases expression | EXP | | 6480464 | acetamide results in increased expression of BHLHA15 mRNA | CTD | PMID:31881176 | acrylamide | increases expression | EXP | | 6480464 | Acrylamide results in increased expression of BHLHA15 mRNA | CTD | PMID:28959563 | aldrin | multiple interactions | ISO | BHLHA15 (Homo sapiens) | 6480464 | [Hexachlorocyclohexane co-treated with Aldrin co-treated with Dieldrin co-treated with Endrin co-treated with Dichlorodiphenyl Dichloroethylene co-treated with Dichlorodiphenyldichloroethane co-treated with DDT co-treated with Simvastatin] results in decreased expression of BHLHA15 mRNA | CTD | PMID:28263720 | ammonium chloride | affects expression | EXP | | 6480464 | Ammonium Chloride affects the expression of BHLHA15 mRNA | CTD | PMID:16483693 | aristolochic acid A | increases expression | ISO | BHLHA15 (Homo sapiens) | 6480464 | aristolochic acid I results in increased expression of BHLHA15 mRNA | CTD | PMID:33212167 | benzo[a]pyrene | increases methylation | ISO | BHLHA15 (Homo sapiens) | 6480464 | Benzo(a)pyrene results in increased methylation of BHLHA15 promoter | CTD | PMID:27901495 | benzo[a]pyrene | decreases methylation | ISO | Bhlha15 (Mus musculus) | 6480464 | Benzo(a)pyrene results in decreased methylation of BHLHA15 exon | CTD | PMID:27901495 | benzo[a]pyrene | increases expression | ISO | Bhlha15 (Mus musculus) | 6480464 | Benzo(a)pyrene results in increased expression of BHLHA15 mRNA | CTD | PMID:32417428 | Benzo[ghi]perylene | increases expression | ISO | Bhlha15 (Mus musculus) | 6480464 | 1 and 12-benzoperylene results in increased expression of BHLHA15 mRNA | CTD | PMID:26377693 | bis(2-ethylhexyl) phthalate | decreases expression | ISO | Bhlha15 (Mus musculus) | 6480464 | Diethylhexyl Phthalate results in decreased expression of BHLHA15 mRNA | CTD | PMID:28085963 | bisphenol A | increases expression | EXP | | 6480464 | bisphenol A results in increased expression of BHLHA15 mRNA | CTD | PMID:25181051 | bisphenol A | increases expression | ISO | Bhlha15 (Mus musculus) | 6480464 | bisphenol A results in increased expression of BHLHA15 mRNA | CTD | PMID:32156529 | bisphenol A | decreases expression | EXP | | 6480464 | bisphenol A results in decreased expression of BHLHA15 mRNA | CTD | PMID:30816183 and PMID:32145629 | bisphenol A | increases methylation | ISO | Bhlha15 (Mus musculus) | 6480464 | bisphenol A results in increased methylation of BHLHA15 promoter | CTD | PMID:27312807 | bromobenzene | decreases expression | EXP | | 6480464 | bromobenzene results in decreased expression of BHLHA15 mRNA | CTD | PMID:32479839 | carbon nanotube | increases expression | ISO | Bhlha15 (Mus musculus) | 6480464 | Nanotubes more ... | CTD | PMID:25554681 and PMID:25620056 | CGP 52608 | multiple interactions | ISO | BHLHA15 (Homo sapiens) | 6480464 | CGP 52608 promotes the reaction [RORA protein binds to BHLHA15 gene] | CTD | PMID:28238834 | chlorohydrocarbon | multiple interactions | EXP | | 6480464 | [Hydrocarbons and Chlorinated co-treated with Polychlorinated Biphenyls co-treated with methylmercuric chloride] results in decreased expression of BHLHA15 mRNA | CTD | PMID:30744511 | choline | multiple interactions | ISO | Bhlha15 (Mus musculus) | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of BHLHA15 mRNA | CTD | PMID:20938992 | ciguatoxin CTX1B | affects expression | ISO | Bhlha15 (Mus musculus) | 6480464 | Ciguatoxins affects the expression of BHLHA15 mRNA | CTD | PMID:18353800 | cisplatin | decreases expression | ISO | BHLHA15 (Homo sapiens) | 6480464 | Cisplatin results in decreased expression of BHLHA15 mRNA | CTD | PMID:27392435 | cisplatin | multiple interactions | ISO | BHLHA15 (Homo sapiens) | 6480464 | [Cisplatin co-treated with jinfukang] results in increased expression of BHLHA15 mRNA | CTD | PMID:27392435 | coumarin | increases expression | EXP | | 6480464 | coumarin results in increased expression of BHLHA15 mRNA | CTD | PMID:18480146 | cyclosporin A | increases expression | ISO | Bhlha15 (Mus musculus) | 6480464 | Cyclosporine results in increased expression of BHLHA15 mRNA | CTD | PMID:19770486 | DDD | multiple interactions | ISO | BHLHA15 (Homo sapiens) | 6480464 | [Hexachlorocyclohexane co-treated with Aldrin co-treated with Dieldrin co-treated with Endrin co-treated with Dichlorodiphenyl Dichloroethylene co-treated with Dichlorodiphenyldichloroethane co-treated with DDT co-treated with Simvastatin] results in decreased expression of BHLHA15 mRNA | CTD | PMID:28263720 | DDE | multiple interactions | ISO | BHLHA15 (Homo sapiens) | 6480464 | [Hexachlorocyclohexane co-treated with Aldrin co-treated with Dieldrin co-treated with Endrin co-treated with Dichlorodiphenyl Dichloroethylene co-treated with Dichlorodiphenyldichloroethane co-treated with DDT co-treated with Simvastatin] results in decreased expression of BHLHA15 mRNA | CTD | PMID:28263720 | DDT | multiple interactions | ISO | BHLHA15 (Homo sapiens) | 6480464 | [Hexachlorocyclohexane co-treated with Aldrin co-treated with Dieldrin co-treated with Endrin co-treated with Dichlorodiphenyl Dichloroethylene co-treated with Dichlorodiphenyldichloroethane co-treated with DDT co-treated with Simvastatin] results in decreased expression of BHLHA15 mRNA | CTD | PMID:28263720 | dicrotophos | increases expression | ISO | BHLHA15 (Homo sapiens) | 6480464 | dicrotophos results in increased expression of BHLHA15 mRNA | CTD | PMID:28302478 | dieldrin | multiple interactions | ISO | BHLHA15 (Homo sapiens) | 6480464 | [Hexachlorocyclohexane co-treated with Aldrin co-treated with Dieldrin co-treated with Endrin co-treated with Dichlorodiphenyl Dichloroethylene co-treated with Dichlorodiphenyldichloroethane co-treated with DDT co-treated with Simvastatin] results in decreased expression of BHLHA15 mRNA | CTD | PMID:28263720 | endosulfan | increases expression | EXP | | 6480464 | Endosulfan results in increased expression of BHLHA15 mRNA | CTD | PMID:29391264 | endrin | multiple interactions | ISO | BHLHA15 (Homo sapiens) | 6480464 | [Hexachlorocyclohexane co-treated with Aldrin co-treated with Dieldrin co-treated with Endrin co-treated with Dichlorodiphenyl Dichloroethylene co-treated with Dichlorodiphenyldichloroethane co-treated with DDT co-treated with Simvastatin] results in decreased expression of BHLHA15 mRNA | CTD | PMID:28263720 | folic acid | multiple interactions | ISO | Bhlha15 (Mus musculus) | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of BHLHA15 mRNA | CTD | PMID:20938992 | furan | increases methylation | EXP | | 6480464 | furan results in increased methylation of BHLHA15 gene | CTD | PMID:22079235 | gamma-hexachlorocyclohexane | multiple interactions | ISO | BHLHA15 (Homo sapiens) | 6480464 | [Hexachlorocyclohexane co-treated with Aldrin co-treated with Dieldrin co-treated with Endrin co-treated with Dichlorodiphenyl Dichloroethylene co-treated with Dichlorodiphenyldichloroethane co-treated with DDT co-treated with Simvastatin] results in decreased expression of BHLHA15 mRNA | CTD | PMID:28263720 | genistein | increases expression | ISO | BHLHA15 (Homo sapiens) | 6480464 | Genistein results in increased expression of BHLHA15 mRNA | CTD | PMID:23019147 | gentamycin | increases expression | EXP | | 6480464 | Gentamicins results in increased expression of BHLHA15 mRNA | CTD | PMID:33387578 | L-methionine | multiple interactions | ISO | Bhlha15 (Mus musculus) | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of BHLHA15 mRNA | CTD | PMID:20938992 | methapyrilene | decreases expression | EXP | | 6480464 | Methapyrilene results in decreased expression of BHLHA15 mRNA | CTD | PMID:30467583 | methylmercury chloride | multiple interactions | EXP | | 6480464 | [Hydrocarbons and Chlorinated co-treated with Polychlorinated Biphenyls co-treated with methylmercuric chloride] results in decreased expression of BHLHA15 mRNA | CTD | PMID:30744511 | orphenadrine | affects expression | EXP | | 6480464 | Orphenadrine affects the expression of BHLHA15 mRNA | CTD | PMID:23665939 | ozone | multiple interactions | ISO | Bhlha15 (Mus musculus) | 6480464 | [Air Pollutants results in increased abundance of [Ozone co-treated with Soot]] which results in increased expression of BHLHA15 mRNA and [Air Pollutants results in increased abundance of Ozone] which results in increased expression of BHLHA15 mRNA | CTD | PMID:27106289 and PMID:34911549 | paracetamol | affects expression | ISO | Bhlha15 (Mus musculus) | 6480464 | Acetaminophen affects the expression of BHLHA15 mRNA | CTD | PMID:17562736 | paracetamol | increases expression | EXP | | 6480464 | Acetaminophen results in increased expression of BHLHA15 mRNA | CTD | PMID:30723492 | paraquat | decreases expression | EXP | | 6480464 | Paraquat results in decreased expression of BHLHA15 mRNA | CTD | PMID:32680482 | pioglitazone | multiple interactions | ISO | Bhlha15 (Mus musculus) | 6480464 | [N-nitroso-tris-chloroethylurea co-treated with pioglitazone] results in decreased expression of BHLHA15 mRNA | CTD | PMID:27935865 | pravastatin | decreases expression | EXP | | 6480464 | Pravastatin results in decreased expression of BHLHA15 mRNA | CTD | PMID:27225895 | pravastatin | decreases expression | ISO | Bhlha15 (Mus musculus) | 6480464 | Pravastatin results in decreased expression of BHLHA15 mRNA | CTD | PMID:27225895 | propiconazole | increases expression | ISO | Bhlha15 (Mus musculus) | 6480464 | propiconazole results in increased expression of BHLHA15 mRNA | CTD | PMID:21278054 | rac-lactic acid | decreases expression | ISO | BHLHA15 (Homo sapiens) | 6480464 | Lactic Acid results in decreased expression of BHLHA15 mRNA | CTD | PMID:30851411 | silicon dioxide | increases expression | ISO | Bhlha15 (Mus musculus) | 6480464 | Silicon Dioxide results in increased expression of BHLHA15 mRNA | CTD | PMID:23221170 | simvastatin | multiple interactions | ISO | BHLHA15 (Homo sapiens) | 6480464 | [Hexachlorocyclohexane co-treated with Aldrin co-treated with Dieldrin co-treated with Endrin co-treated with Dichlorodiphenyl Dichloroethylene co-treated with Dichlorodiphenyldichloroethane co-treated with DDT co-treated with Simvastatin] results in decreased expression of BHLHA15 mRNA | CTD | PMID:28263720 | sodium arsenite | decreases expression | EXP | | 6480464 | sodium arsenite results in decreased expression of BHLHA15 mRNA | CTD | PMID:35314868 | sodium dichromate | increases expression | EXP | | 6480464 | sodium bichromate results in increased expression of BHLHA15 mRNA | CTD | PMID:25993096 | testosterone | multiple interactions | ISO | Bhlha15 (Mus musculus) | 6480464 | 1 more ... | CTD | PMID:33848595 | testosterone | decreases expression | ISO | Bhlha15 (Mus musculus) | 6480464 | Testosterone deficiency results in decreased expression of BHLHA15 mRNA | CTD | PMID:33848595 | tetrachloromethane | multiple interactions | EXP | | 6480464 | schizandrin B inhibits the reaction [Carbon Tetrachloride results in increased expression of BHLHA15 mRNA] | CTD | PMID:31150632 | tetrachloromethane | increases expression | ISO | Bhlha15 (Mus musculus) | 6480464 | Carbon Tetrachloride results in increased expression of BHLHA15 mRNA | CTD | PMID:31919559 | tetrachloromethane | increases expression | EXP | | 6480464 | Carbon Tetrachloride results in increased expression of BHLHA15 mRNA | CTD | PMID:30723492 and PMID:31150632 | thioacetamide | decreases expression | EXP | | 6480464 | Thioacetamide results in decreased expression of BHLHA15 mRNA | CTD | PMID:34492290 | titanium dioxide | increases expression | ISO | Bhlha15 (Mus musculus) | 6480464 | titanium dioxide results in increased expression of BHLHA15 mRNA | CTD | PMID:27760801 | titanium dioxide | increases expression | EXP | | 6480464 | titanium dioxide results in increased expression of BHLHA15 mRNA | CTD | PMID:30012374 | trichloroethene | increases expression | ISO | Bhlha15 (Mus musculus) | 6480464 | Trichloroethylene results in increased expression of BHLHA15 mRNA | CTD | PMID:25549359 | trichloroethene | decreases expression | EXP | | 6480464 | Trichloroethylene results in decreased expression of BHLHA15 mRNA | CTD | PMID:33387578 | triptonide | increases expression | ISO | Bhlha15 (Mus musculus) | 6480464 | triptonide results in increased expression of BHLHA15 mRNA | CTD | PMID:33045310 | urethane | decreases expression | ISO | BHLHA15 (Homo sapiens) | 6480464 | Urethane results in decreased expression of BHLHA15 mRNA | CTD | PMID:28818685 | valproic acid | affects expression | ISO | Bhlha15 (Mus musculus) | 6480464 | Valproic Acid affects the expression of BHLHA15 mRNA | CTD | PMID:17292431 | valproic acid | increases methylation | ISO | BHLHA15 (Homo sapiens) | 6480464 | Valproic Acid results in increased methylation of BHLHA15 gene | CTD | PMID:29154799 | XL147 | multiple interactions | ISO | Bhlha15 (Mus musculus) | 6480464 | [N-nitroso-tris-chloroethylurea co-treated with XL147] results in decreased expression of BHLHA15 mRNA | CTD | PMID:27935865 | zaragozic acid A | decreases expression | ISO | Bhlha15 (Mus musculus) | 6480464 | squalestatin 1 results in decreased expression of BHLHA15 mRNA | CTD | PMID:27225895 | zaragozic acid A | decreases expression | EXP | | 6480464 | squalestatin 1 results in decreased expression of BHLHA15 mRNA | CTD | PMID:27225895 | |