Map1b (microtubule-associated protein 1B) - Rat Genome Database

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Gene: Map1b (microtubule-associated protein 1B) Rattus norvegicus
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Symbol: Map1b
Name: microtubule-associated protein 1B
RGD ID: 3043
Description: Enables actin binding activity; microtubule binding activity; and phospholipid binding activity. Involved in several processes, including nervous system development; positive regulation of cell differentiation; and regulation of microtubule polymerization or depolymerization. Located in several cellular components, including axon; dendrite; and perikaryon. Part of microtubule associated complex. Biomarker of hypothyroidism. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 83 and periventricular nodular heterotopia. Orthologous to human MAP1B (microtubule associated protein 1B); PARTICIPATES IN Reelin signaling pathway; INTERACTS WITH (+)-schisandrin B; 1-naphthyl isothiocyanate; 2,2',4,4'-Tetrabromodiphenyl ether.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: MAP-1B; Mtap1b; neuraxin
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Candidate Gene For: Bp115
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8232,551,423 - 32,644,471 (-)NCBIGRCr8
mRatBN7.2230,817,261 - 30,910,458 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl230,817,261 - 30,910,317 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx237,887,269 - 37,980,116 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0235,981,626 - 36,074,463 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0230,785,607 - 30,878,656 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0229,675,391 - 29,768,750 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl229,675,391 - 29,768,750 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0248,837,124 - 48,930,483 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4230,415,235 - 30,508,354 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1230,339,919 - 30,360,389 (-)NCBI
Celera226,841,920 - 26,934,955 (-)NCBICelera
Cytogenetic Map2q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model



  
Object Symbol
Species
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Evidence
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Reference
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Original Reference(s)
Map1bRatBrain Injuries  IEP 2304029protein:increased expression and increased phosphorylation:brainRGD 
Map1bRatExperimental Seizures  IEP 2304062mRNA and protein:altered localization:brainRGD 
Map1bRatExperimental Seizures  IEP 2304015mRNA:increased expression:hippocampusRGD 
Map1bRathypothyroidism  IEP 2304042protein:increased expression:cerebellumRGD 
Map1bRatSpinal Cord Injuries  IEP 2304007protein:increased phosphorylation:spinal cord and neuronRGD 
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Original Reference(s)
Map1bRatautism spectrum disorder  ISOMAP1B (Homo sapiens)8554872ClinVar Annotator: match by term: Autism spectrum disorderClinVarPMID:25741868 and PMID:30150678
Map1bRatautosomal dominant nonsyndromic deafness 83  ISOMAP1B (Homo sapiens)8554872ClinVar Annotator: match by term: Deafness and autosomal dominant 83ClinVarPMID:25741868 more ...
Map1bRatDevelopmental Disabilities  ISOMAP1B (Homo sapiens)8554872ClinVar Annotator: match by term: Global developmental delayClinVarPMID:25741868 and PMID:30979967
Map1bRatgenetic disease  ISOMAP1B (Homo sapiens)8554872ClinVar Annotator: match by term: Inborn genetic diseasesClinVarPMID:25741868 and PMID:28492532
Map1bRatMacrocephaly  ISOMAP1B (Homo sapiens)8554872ClinVar Annotator: match by term: MacrocephalyClinVarPMID:25741868
Map1bRatNeurodevelopmental Disorders  ISOMAP1B (Homo sapiens)8554872ClinVar Annotator: match by term: Neurodevelopmental disorderClinVarPMID:25741868 and PMID:30150678
Map1bRatperiventricular nodular heterotopia  ISOMAP1B (Homo sapiens)8554872ClinVar Annotator: match by term: Periventricular nodular heterotopiaClinVarPMID:25741868 more ...
Map1bRatPeriventricular Nodular Heterotopia 5  ISOMAP1B (Homo sapiens)8554872ClinVar Annotator: match by term: Chromosome 5Q14.3 deletion syndrome and distalClinVarPMID:25741868
Map1bRatPeriventricular Nodular Heterotopia 9  ISOMAP1B (Homo sapiens)8554872ClinVar more ...ClinVarPMID:25741868 more ...
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Original Reference(s)
Map1bRatautosomal dominant nonsyndromic deafness 83  ISOMAP1B (Homo sapiens)7240710 OMIM 
Map1bRatPeriventricular Nodular Heterotopia 9  ISOMAP1B (Homo sapiens)7240710 OMIM 

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Object Symbol
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Original Reference(s)
Map1bRat(+)-schisandrin B multiple interactionsEXP 6480464schizandrin B inhibits the reaction [Carbon Tetrachloride results in increased expression of MAP1B mRNA]CTDPMID:31150632
Map1bRat1,1-dichloroethene increases expressionISOMap1b (Mus musculus)6480464vinylidene chloride results in increased expression of MAP1B mRNACTDPMID:26682919
Map1bRat1,2-dichloroethane affects expressionISOMap1b (Mus musculus)6480464ethylene dichloride affects the expression of MAP1B mRNACTDPMID:28960355
Map1bRat1,2-dimethylhydrazine multiple interactionsISOMap1b (Mus musculus)6480464[1 and 2-Dimethylhydrazine co-treated with Folic Acid] results in increased expression of MAP1B mRNACTDPMID:22206623
Map1bRat1-naphthyl isothiocyanate increases expressionEXP 64804641-Naphthylisothiocyanate results in increased expression of MAP1B mRNACTDPMID:30723492
Map1bRat17beta-estradiol increases expressionISOMAP1B (Homo sapiens)6480464Estradiol results in increased expression of MAP1B mRNACTDPMID:20106945 and PMID:31614463
Map1bRat17beta-estradiol multiple interactionsISOMAP1B (Homo sapiens)6480464[Estradiol co-treated with TGFB1 protein] results in increased expression of MAP1B mRNACTDPMID:30165855
Map1bRat17beta-estradiol decreases expressionISOMAP1B (Homo sapiens)6480464Estradiol results in decreased expression of MAP1B mRNACTDPMID:19167446
Map1bRat2,2',4,4',5,5'-hexachlorobiphenyl multiple interactionsISOMap1b (Mus musculus)6480464[2 more ...CTDPMID:25510870
Map1bRat2,2',4,4'-Tetrabromodiphenyl ether decreases expressionEXP 64804642 more ...CTDPMID:21394737
Map1bRat2,2',5,5'-tetrachlorobiphenyl multiple interactionsISOMap1b (Mus musculus)6480464[2 more ...CTDPMID:25510870
Map1bRat2,3,7,8-tetrachlorodibenzodioxine decreases expressionISOMap1b (Mus musculus)6480464Tetrachlorodibenzodioxin results in decreased expression of MAP1B mRNACTDPMID:19933214
Map1bRat2,3,7,8-tetrachlorodibenzodioxine decreases expressionEXP 6480464Tetrachlorodibenzodioxin results in decreased expression of MAP1B mRNACTDPMID:33387578
Map1bRat2,3,7,8-tetrachlorodibenzodioxine increases expressionISOMAP1B (Homo sapiens)6480464Tetrachlorodibenzodioxin results in increased expression of MAP1B mRNACTDPMID:21632981 and PMID:21802500
Map1bRat2,3,7,8-tetrachlorodibenzodioxine affects expressionISOMap1b (Mus musculus)6480464Tetrachlorodibenzodioxin affects the expression of MAP1B mRNACTDPMID:21570461
Map1bRat2,3,7,8-tetrachlorodibenzodioxine affects expressionEXP 6480464Tetrachlorodibenzodioxin affects the expression of MAP1B mRNACTDPMID:22298810 and PMID:34747641
Map1bRat2,3,7,8-tetrachlorodibenzodioxine affects expressionISOMAP1B (Homo sapiens)6480464Tetrachlorodibenzodioxin affects the expression of MAP1B mRNACTDPMID:20106945
Map1bRat2,5-hexanedione decreases expressionEXP 64804642 more ...CTDPMID:20554699 and PMID:31760062
Map1bRat2-methylcholine affects expressionISOMAP1B (Homo sapiens)6480464beta-methylcholine affects the expression of MAP1B mRNACTDPMID:21179406
Map1bRat3,4-methylenedioxymethamphetamine increases expressionEXP 6480464N-Methyl-3 and 4-methylenedioxyamphetamine results in increased expression of MAP1B mRNACTDPMID:30071829

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Biological Process
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Original Reference(s)
Map1bRataxon extension acts_upstream_of_or_withinIEAUniProtKB:P14873 and ensembl:ENSMUSP000000683741600115GO_REF:0000107EnsemblGO_REF:0000107
Map1bRataxon extension acts_upstream_of_or_withinISOMap1b (Mus musculus)1624291MGI:2148182 PMID:16536727RGDPMID:16536727
Map1bRataxonogenesis involved_inIBAFB:FBgn0259108 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Map1bRataxonogenesis acts_upstream_of_or_withinIEAUniProtKB:P14873 and ensembl:ENSMUSP000000683741600115GO_REF:0000107EnsemblGO_REF:0000107
Map1bRataxonogenesis acts_upstream_of_or_withinISOMap1b (Mus musculus)1624291MGI:97180 PMID:11891784RGDPMID:11891784
Map1bRatcellular response to growth factor stimulus  IEP 2304027 RGD 
Map1bRatcellular response to peptide hormone stimulus  IEP 2304027 RGD 
Map1bRatdendrite development involved_inIBAFB:FBgn0259108 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Map1bRatdendrite development acts_upstream_of_or_withinIEAUniProtKB:P14873 and ensembl:ENSMUSP000000683741600115GO_REF:0000107EnsemblGO_REF:0000107
Map1bRatdendrite development acts_upstream_of_or_withinISOMap1b (Mus musculus)1624291MGI:2152588 PMID:11581286RGDPMID:11581286
Map1bRatdevelopmental maturation  IEP 2304023 RGD 
Map1bRatestablishment of monopolar cell polarity acts_upstream_of_or_withinISOMap1b (Mus musculus)1624291 PMID:11029282RGDPMID:11029282
Map1bRatestablishment of monopolar cell polarity acts_upstream_of_or_withinIEAUniProtKB:P14873 and ensembl:ENSMUSP000000683741600115GO_REF:0000107EnsemblGO_REF:0000107
Map1bRatinduction of synaptic plasticity by chemical substance  IEP 2304033 RGD 
Map1bRatintracellular transport acts_upstream_ofIEAUniProtKB:P14873 and ensembl:ENSMUSP000000683741600115GO_REF:0000107EnsemblGO_REF:0000107
Map1bRatintracellular transport acts_upstream_ofISOMap1b (Mus musculus)1624291MGI:2148182 PMID:16536727RGDPMID:16536727
Map1bRatmicrotubule bundle formation  IDA 71122 RGD 
Map1bRatmicrotubule bundle formation acts_upstream_of_or_withinISOMap1b (Mus musculus)1624291MGI:2152588 PMID:11581286RGDPMID:11581286
Map1bRatmicrotubule bundle formation acts_upstream_of_or_withinIEAUniProtKB:P14873 and ensembl:ENSMUSP000000683741600115GO_REF:0000107EnsemblGO_REF:0000107
Map1bRatmicrotubule cytoskeleton organization involved_inIEAInterPro:IPR0260741600115GO_REF:0000002InterProGO_REF:0000002
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Cellular Component
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Original Reference(s)
Map1bRatapical dendrite located_inIDA 13464259PMID:10640627ARUK-UCL 
Map1bRataxon  IDA 633201 RGD 
Map1bRataxon located_inIDA 13464259PMID:10640627ARUK-UCL 
Map1bRataxon located_inIDA 13514087PMID:28426968ARUK-UCL 
Map1bRataxon located_inIDA 13441203PMID:28521134UniProt 
Map1bRatbasal dendrite located_inIDA 13464259PMID:10640627ARUK-UCL 
Map1bRatcell projection located_inIEAUniProtKB-KW:KW-09661600115GO_REF:0000043UniProtGO_REF:0000043
Map1bRatcytoplasm located_inIEAUniProtKB-SubCell:SL-00861600115GO_REF:0000044UniProtGO_REF:0000044
Map1bRatcytoplasm located_inIEAUniProtKB-KW:KW-09631600115GO_REF:0000043UniProtGO_REF:0000043
Map1bRatcytoskeleton located_inIEAUniProtKB-KW:KW-02061600115GO_REF:0000043UniProtGO_REF:0000043
Map1bRatcytoskeleton located_inIEAUniProtKB-SubCell:SL-00901600115GO_REF:0000044UniProtGO_REF:0000044
Map1bRatcytosol located_inIEAUniProtKB:P46821 and ensembl:ENSP000002967551600115GO_REF:0000107EnsemblGO_REF:0000107
Map1bRatcytosol located_inISOMap1b (Mus musculus)1624291 PMID:16885219RGDPMID:16885219
Map1bRatcytosol is_active_inIBAMGI:1306776 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Map1bRatcytosol located_inISOMAP1B (Homo sapiens)1624291 RGDGO_REF:0000052
Map1bRatcytosol located_inIEAUniProtKB:P14873 and ensembl:ENSMUSP000000683741600115GO_REF:0000107EnsemblGO_REF:0000107
Map1bRatdendrite  IDA 633201 RGD 
Map1bRatdendrite located_inIEAUniProtKB:P14873 and ensembl:ENSMUSP000000683741600115GO_REF:0000107EnsemblGO_REF:0000107
Map1bRatdendrite is_active_inIBAFB:FBgn0259108 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Map1bRatdendrite located_inIDA 13464259PMID:10640627ARUK-UCL 
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Molecular Function
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Imported Annotations - PID (archival)

Object Symbol
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Original Reference(s)
Map1bRatReelin signaling pathway   ISOMAP1B (Homo sapiens)6484113 PIDPID:200062

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#
Reference Title
Reference Citation
1. Neuronal differentiation of adult rat hippocampus-derived neural stem cells transplanted into embryonic rat explanted retinas with retinoic acid pretreatment. Akita J, etal., Brain Res. 2002 Nov 8;954(2):286-93.
2. Effect of hypothyroidism on the expression of three microtubule-associated proteins (1A, 1B and 2) in developing rat cerebellum. Benjamin S, etal., Neuroscience. 1988 Dec;27(3):931-9.
3. Agrin induced morphological and structural changes in growth cones of cultured hippocampal neurons. Bergstrom RA, etal., Neuroscience. 2007 Nov 9;149(3):527-36. Epub 2007 Aug 14.
4. Microtubule-associated protein 1B-light chain 1 enhances activation of Rap1 by exchange protein activated by cyclic AMP but not intracellular targeting. Borland G, etal., Mol Pharmacol. 2006 Jan;69(1):374-84. Epub 2005 Oct 21.
5. Attenuation of microtubule-associated protein 1B expression by antisense oligodeoxynucleotides inhibits initiation of neurite outgrowth. Brugg B, etal., Neuroscience. 1993 Feb;52(3):489-96.
6. MAP-1B/TAU functional redundancy during laminin-enhanced axonal growth. DiTella MC, etal., J Cell Sci. 1996 Feb;109 ( Pt 2):467-77.
7. Neuronal abnormalities in microtubule-associated protein 1B mutant mice. Edelmann W, etal., Proc Natl Acad Sci U S A 1996 Feb 6;93(3):1270-5.
8. Bilateral growth-related protein expression suggests a transient increase in regenerative potential following brain trauma. Emery DL, etal., J Comp Neurol. 2000 Aug 28;424(3):521-31.
9. Regenerating sciatic nerve axons contain the adult rather than the embryonic pattern of microtubule associated proteins. Fawcett JW, etal., Neuroscience. 1994 Aug;61(4):789-804.
10. Synaptic plasticity is preserved in the temporal cortex of 20-month-old rats. Fischer B and Wagner AP, Arch Gerontol Geriatr. 1997 Jul-Aug;25(1):27-39.
11. Intracerebral injection of AMPA causes axonal damage in vivo. Fowler JH, etal., Brain Res. 2003 Nov 21;991(1-2):104-12.
12. Microtubule-associated protein 1B: a neuronal binding partner for myelin-associated glycoprotein. Franzen R, etal., J Cell Biol. 2001 Dec 10;155(6):893-8. Epub 2001 Dec 3.
13. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
14. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
15. Regulation of phosphorylation of neuronal microtubule-associated proteins MAP1b and MAP2 by protein phosphatase-2A and -2B in rat brain. Gong CX, etal., Brain Res. 2000 Jan 24;853(2):299-309.
16. Maternal protein restriction early in rat pregnancy alters brain development in the progeny. Gressens P, etal., Brain Res Dev Brain Res. 1997 Oct 20;103(1):21-35.
17. MAP2 Defines a Pre-axonal Filtering Zone to Regulate KIF1- versus KIF5-Dependent Cargo Transport in Sensory Neurons. Gumy LF, etal., Neuron. 2017 Apr 19;94(2):347-362.e7. doi: 10.1016/j.neuron.2017.03.046.
18. Localization of microtubule-associated protein (MAP) 1B in the postsynaptic densities of the rat cerebral cortex. Kawakami S, etal., Cell Mol Neurobiol. 2003 Dec;23(6):887-94.
19. Direct interaction and functional coupling between human 5-HT6 receptor and the light chain 1 subunit of the microtubule-associated protein 1B (MAP1B-LC1). Kim SH, etal., PLoS One. 2014 Mar 10;9(3):e91402. doi: 10.1371/journal.pone.0091402. eCollection 2014.
20. Changes in the subcellular distribution of microtubule-associated protein 1B during synaptogenesis of cultured rat cortical neurons. Kitamura C, etal., Cell Mol Neurobiol. 2007 Feb;27(1):57-73. Epub 2006 Dec 7.
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PMID:2555150   PMID:8666295   PMID:8889548   PMID:9615228   PMID:11029282   PMID:11581286   PMID:11891784   PMID:12060780   PMID:12270035   PMID:12376528   PMID:12477932   PMID:15090053  
PMID:15277470   PMID:15731007   PMID:15737742   PMID:16536727   PMID:16641100   PMID:16854843   PMID:16855020   PMID:16885219   PMID:17114649   PMID:17704770   PMID:18063656   PMID:19549690  
PMID:19567321   PMID:19616629   PMID:19805073   PMID:21508097   PMID:21700703   PMID:22033417   PMID:22120110   PMID:22169499   PMID:22779921   PMID:22871113   PMID:23300879   PMID:24625528  
PMID:24664738   PMID:25002582   PMID:25483588   PMID:25788676   PMID:28904092   PMID:29476059   PMID:30914445   PMID:31686426   PMID:32357304   PMID:35352799  



Map1b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8232,551,423 - 32,644,471 (-)NCBIGRCr8
mRatBN7.2230,817,261 - 30,910,458 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl230,817,261 - 30,910,317 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx237,887,269 - 37,980,116 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0235,981,626 - 36,074,463 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0230,785,607 - 30,878,656 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0229,675,391 - 29,768,750 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl229,675,391 - 29,768,750 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0248,837,124 - 48,930,483 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4230,415,235 - 30,508,354 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1230,339,919 - 30,360,389 (-)NCBI
Celera226,841,920 - 26,934,955 (-)NCBICelera
Cytogenetic Map2q12NCBI
MAP1B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38572,107,475 - 72,209,565 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl572,107,234 - 72,209,565 (+)EnsemblGRCh38hg38GRCh38
GRCh37571,403,302 - 71,505,392 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36571,438,874 - 71,541,153 (+)NCBINCBI36Build 36hg18NCBI36
Build 34571,515,074 - 71,538,609NCBI
Celera567,298,553 - 67,400,783 (+)NCBICelera
Cytogenetic Map5q13.2NCBI
HuRef566,608,550 - 66,710,969 (+)NCBIHuRef
CHM1_1570,835,805 - 70,938,065 (+)NCBICHM1_1
T2T-CHM13v2.0572,588,652 - 72,690,733 (+)NCBIT2T-CHM13v2.0
Map1b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391399,557,972 - 99,653,110 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1399,557,954 - 99,653,048 (-)EnsemblGRCm39 Ensembl
GRCm381399,421,464 - 99,516,602 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1399,421,446 - 99,516,540 (-)EnsemblGRCm38mm10GRCm38
MGSCv3713100,191,419 - 100,286,557 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3613100,524,598 - 100,616,697 (-)NCBIMGSCv36mm8
Celera13103,077,104 - 103,171,785 (-)NCBICelera
Cytogenetic Map13D1NCBI
cM Map1352.9NCBI
Map1b
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955575913,723 - 1,021,028 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955575914,607 - 1,020,971 (+)NCBIChiLan1.0ChiLan1.0
MAP1B
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2443,104,167 - 43,206,535 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1541,257,795 - 41,360,140 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0543,102,739 - 43,204,978 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1543,701,530 - 43,803,393 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl543,701,530 - 43,803,393 (-)Ensemblpanpan1.1panPan2
MAP1B
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1255,175,000 - 55,258,160 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl255,174,837 - 55,253,975 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha252,143,740 - 52,226,846 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0255,691,610 - 55,774,703 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl255,691,446 - 55,771,854 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1252,751,922 - 52,834,958 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0253,519,445 - 53,602,504 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0254,410,527 - 54,493,742 (+)NCBIUU_Cfam_GSD_1.0
Map1b
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213186,487,418 - 186,592,600 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365494,266,351 - 4,371,644 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365494,266,371 - 4,371,579 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MAP1B
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1648,403,568 - 48,498,885 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11648,403,338 - 48,501,453 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21652,391,814 - 52,489,652 (+)NCBISscrofa10.2Sscrofa10.2susScr3
MAP1B
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1466,445,687 - 66,548,595 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl466,445,901 - 66,549,142 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604915,202,185 - 15,305,303 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Map1b
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046249051,198,205 - 1,304,309 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046249051,198,157 - 1,304,128 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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Variants in Map1b
825 total Variants

Predicted Target Of
Summary Value
Count of predictions:570
Count of miRNA genes:277
Interacting mature miRNAs:358
Transcripts:ENSRNOT00000023460
Prediction methods:Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 35 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
10755430Coatc6Coat color QTL 60.02576coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)21159110056591100Rat
7387318Stl32Serum triglyceride level QTL 323.20.0003blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)22238462767384627Rat
631682Bp115Blood pressure QTL 1154.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2137410502Rat
10755434Coatc7Coat color QTL 70.04794coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)23064806575648065Rat
10755499Bp389Blood pressure QTL 3892.61arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)218960362228801039Rat
738010Lnnr3Liver neoplastic nodule remodeling QTL 32.94liver integrity trait (VT:0010547)liver remodeling tumorous lesion number (CMO:0001461)2141244106Rat
1358917Cm42Cardiac mass QTL 422.82heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
1300160Hrtrt3Heart rate QTL 33.62heart pumping trait (VT:2000009)absolute change in heart rate (CMO:0000534)22997159351729300Rat
731167Glom4Glomerulus QTL 42.40.0082kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)22030467265304672Rat
1358913Cm41Cardiac mass QTL 412.73heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat

1 to 10 of 35 rows
X51396  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8232,554,812 - 32,554,915 (+)Marker Load Pipeline
mRatBN7.2230,820,649 - 30,820,753 (+)MAPPERmRatBN7.2
Rnor_6.0229,678,780 - 29,678,883NCBIRnor6.0
Rnor_5.0248,840,513 - 48,840,616UniSTSRnor5.0
RGSC_v3.4230,418,624 - 30,418,727UniSTSRGSC3.4
Celera226,845,309 - 26,845,412UniSTS
Cytogenetic Map2q12UniSTS
Mtap1b  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2230,910,018 - 30,910,198 (+)MAPPERmRatBN7.2
Rnor_6.0229,768,452 - 29,768,631NCBIRnor6.0
Rnor_5.0248,930,185 - 48,930,364UniSTSRnor5.0
RGSC_v3.4230,508,056 - 30,508,235UniSTSRGSC3.4
Celera226,934,657 - 26,934,836UniSTS
Cytogenetic Map2q12UniSTS
RH137448  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2230,896,129 - 30,896,339 (+)MAPPERmRatBN7.2
Rnor_6.0229,754,567 - 29,754,776NCBIRnor6.0
Rnor_5.0248,916,300 - 48,916,509UniSTSRnor5.0
RGSC_v3.4230,494,171 - 30,494,380UniSTSRGSC3.4
Celera226,920,770 - 26,920,979UniSTS
Cytogenetic Map2q12UniSTS
UniSTS:143928  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2230,826,822 - 30,827,027 (+)MAPPERmRatBN7.2
Rnor_6.0229,684,953 - 29,685,157NCBIRnor6.0
Rnor_5.0248,846,686 - 48,846,890UniSTSRnor5.0
RGSC_v3.4230,424,797 - 30,425,001UniSTSRGSC3.4
Celera226,851,483 - 26,851,687UniSTS
Cytogenetic Map2q12UniSTS




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31


1 to 28 of 28 rows
RefSeq Transcripts NM_019217 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039101889 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AA925503 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF035827 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF078778 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF079778 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC158858 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BF286433 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BG378086 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BG665276 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CA503854 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CA510735 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CA510940 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CB576609 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CB579120 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CB580055 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CB583564 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CB584802 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CB610210 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CB810012 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CF977184 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473955 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CO393350 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ214081 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000002 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U52950 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X16623 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X60370 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
1 to 28 of 28 rows

Ensembl Acc Id: ENSRNOT00000023460   ⟹   ENSRNOP00000023460
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl230,817,261 - 30,910,317 (-)Ensembl
Rnor_6.0 Ensembl229,675,391 - 29,768,750 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000103521   ⟹   ENSRNOP00000082357
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl230,817,279 - 30,910,317 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000113536   ⟹   ENSRNOP00000079012
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl230,817,261 - 30,910,317 (-)Ensembl
RefSeq Acc Id: NM_019217   ⟹   NP_062090
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8232,551,423 - 32,644,471 (-)NCBI
mRatBN7.2230,817,261 - 30,910,317 (-)NCBI
Rnor_6.0229,675,391 - 29,768,750 (-)NCBI
Rnor_5.0248,837,124 - 48,930,483 (-)NCBI
RGSC_v3.4230,415,235 - 30,508,354 (-)RGD
Celera226,841,920 - 26,934,955 (-)RGD
Sequence:
RefSeq Acc Id: XM_039101889   ⟹   XP_038957817
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8232,551,441 - 32,579,474 (-)NCBI
mRatBN7.2230,817,279 - 30,845,316 (-)NCBI
RefSeq Acc Id: NP_062090   ⟸   NM_019217
- UniProtKB: Q9QW92 (UniProtKB/Swiss-Prot),   Q9ER21 (UniProtKB/Swiss-Prot),   Q62958 (UniProtKB/Swiss-Prot),   F1LRL9 (UniProtKB/Swiss-Prot),   B0BNK3 (UniProtKB/Swiss-Prot),   P15205 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSRNOP00000023460   ⟸   ENSRNOT00000023460
RefSeq Acc Id: XP_038957817   ⟸   XM_039101889
- Peptide Label: isoform X1
- UniProtKB: Q9QW92 (UniProtKB/Swiss-Prot),   Q9ER21 (UniProtKB/Swiss-Prot),   Q62958 (UniProtKB/Swiss-Prot),   P15205 (UniProtKB/Swiss-Prot),   F1LRL9 (UniProtKB/Swiss-Prot),   B0BNK3 (UniProtKB/Swiss-Prot),   A6I569 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000082357   ⟸   ENSRNOT00000103521
Ensembl Acc Id: ENSRNOP00000079012   ⟸   ENSRNOT00000113536

Name Modeler Protein Id AA Range Protein Structure
AF-P15205-F1-model_v2 AlphaFold P15205 1-2461 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13691098
Promoter ID:EPDNEW_R1623
Type:multiple initiation site
Name:Map1b_1
Description:microtubule-associated protein 1B
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0229,768,644 - 29,768,704EPDNEW


1 to 34 of 34 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-54697 BioCyc
Ensembl Genes ENSRNOG00000017428 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000023460 ENTREZGENE
  ENSRNOT00000023460.6 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7930451 IMAGE-MGC_LOAD
InterPro MAP1 UniProtKB/Swiss-Prot
  MAP1B_neuraxin UniProtKB/Swiss-Prot
KEGG Report rno:29456 UniProtKB/Swiss-Prot
MGC_CLONE MGC:188411 IMAGE-MGC_LOAD
NCBI Gene 29456 ENTREZGENE
PANTHER PTHR13843 UniProtKB/Swiss-Prot
  PTHR13843:SF5 UniProtKB/Swiss-Prot
Pfam MAP1B_neuraxin UniProtKB/Swiss-Prot
PhenoGen Map1b PhenoGen
PROSITE MAP1B_NEURAXIN UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000017428 RatGTEx
TIGR TC228428
  TC228522
UniProt A0A8I5ZMJ9_RAT UniProtKB/TrEMBL
  A0A8I5ZWW4_RAT UniProtKB/TrEMBL
  A6I568_RAT UniProtKB/TrEMBL
  A6I569 ENTREZGENE, UniProtKB/TrEMBL
  A6I570_RAT UniProtKB/TrEMBL
  B0BNK3 ENTREZGENE
  F1LRL9 ENTREZGENE
  MAP1B_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q62958 ENTREZGENE
  Q9ER21 ENTREZGENE
  Q9QW92 ENTREZGENE
UniProt Secondary B0BNK3 UniProtKB/Swiss-Prot
  F1LRL9 UniProtKB/Swiss-Prot
  Q62958 UniProtKB/Swiss-Prot
  Q9ER21 UniProtKB/Swiss-Prot
  Q9QW92 UniProtKB/Swiss-Prot
1 to 34 of 34 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-08-29 Map1b  microtubule-associated protein 1B  Mtap1b  microtubule-associated protein 1B  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-07-21 Mtap1b  microtubule-associated protein 1B  Map1b  microtubule-associated protein 1b  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Map1b  microtubule-associated protein 1b      Name updated 70584 APPROVED

Note Type Note Reference
gene_domains contains two seperate microtubule binding domains one of which consists of basic repeat motif KKEE(I/V) 69879