Map1b (microtubule-associated protein 1B) - Rat Genome Database

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Gene: Map1b (microtubule-associated protein 1B) Rattus norvegicus
Analyze
Symbol: Map1b
Name: microtubule-associated protein 1B
RGD ID: 3043
Description: Enables actin binding activity; microtubule binding activity; and phospholipid binding activity. Involved in several processes, including nervous system development; positive regulation of cell differentiation; and regulation of microtubule polymerization or depolymerization. Located in several cellular components, including axon; dendrite; and perikaryon. Part of microtubule associated complex. Biomarker of hypothyroidism and visual epilepsy. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness and periventricular nodular heterotopia. Orthologous to human MAP1B (microtubule associated protein 1B); PARTICIPATES IN Reelin signaling pathway; INTERACTS WITH (+)-schisandrin B; 1-naphthyl isothiocyanate; 2,2',4,4'-Tetrabromodiphenyl ether.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: MAP-1B; Mtap1b; neuraxin
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Candidate Gene For: Bp115
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8232,551,423 - 32,644,471 (-)NCBIGRCr8
mRatBN7.2230,817,261 - 30,910,458 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl230,817,261 - 30,910,317 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx237,887,269 - 37,980,116 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0235,981,626 - 36,074,463 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0230,785,607 - 30,878,656 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0229,675,391 - 29,768,750 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl229,675,391 - 29,768,750 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0248,837,124 - 48,930,483 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4230,415,235 - 30,508,354 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1230,339,919 - 30,360,389 (-)NCBI
Celera226,841,920 - 26,934,955 (-)NCBICelera
Cytogenetic Map2q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
1,1-dichloroethene  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (EXP)
17beta-estradiol  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,5-hexanedione  (EXP)
2-methylcholine  (ISO)
3,4-methylenedioxymethamphetamine  (EXP)
3-chloropropane-1,2-diol  (EXP)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
aflatoxin B1  (EXP,ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
antimycin A  (ISO)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
atrazine  (EXP)
azathioprine  (ISO)
azoxystrobin  (ISO)
benzo[a]pyrene  (ISO)
beta-lapachone  (ISO)
bexarotene  (EXP)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
Brodifacoum  (EXP)
butanal  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (ISO)
cannabidiol  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chlordecone  (ISO)
clobetasol  (ISO)
clozapine  (ISO)
cobalt dichloride  (ISO)
cocaine  (EXP,ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) chloride  (ISO)
copper(II) sulfate  (ISO)
coumarin  (ISO)
coumestrol  (ISO)
CU-O LINKAGE  (ISO)
cyclosporin A  (ISO)
daunorubicin  (ISO)
DDE  (ISO)
deguelin  (ISO)
dexamethasone  (EXP)
diarsenic trioxide  (ISO)
diazinon  (ISO)
dibutyl phthalate  (EXP)
diiodine  (EXP)
dimethylarsinic acid  (EXP)
diuron  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
Enterolactone  (ISO)
enzyme inhibitor  (ISO)
ethanol  (EXP,ISO)
fenpyroximate  (ISO)
fipronil  (EXP)
fluoxetine  (EXP)
folic acid  (ISO)
FR900359  (ISO)
geldanamycin  (ISO)
glyphosate  (EXP)
gold atom  (ISO)
gold(0)  (ISO)
hydrogen peroxide  (ISO)
hydroquinone  (ISO)
ivermectin  (ISO)
ketamine  (EXP)
lead diacetate  (ISO)
leflunomide  (ISO)
lipopolysaccharide  (ISO)
methylmercury chloride  (ISO)
methylseleninic acid  (ISO)
miconazole  (ISO)
mifepristone  (ISO)
mono(2-ethylhexyl) phthalate  (EXP)
N,N-diethyl-m-toluamide  (EXP)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
paracetamol  (ISO)
PCB138  (EXP,ISO)
perfluorooctanoic acid  (ISO)
permethrin  (EXP)
phenylmercury acetate  (ISO)
phenytoin  (ISO)
potassium chromate  (ISO)
progesterone  (EXP)
propanal  (ISO)
pyrimidifen  (ISO)
quercetin  (ISO)
resveratrol  (ISO)
rotenone  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (EXP,ISO)
sulforaphane  (ISO)
sunitinib  (ISO)
T-2 toxin  (ISO)
tebufenpyrad  (ISO)
testosterone  (EXP)
tetrachloromethane  (EXP)
tetrahydropalmatine  (ISO)
thapsigargin  (EXP)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
trichloroethene  (ISO)
valproic acid  (EXP,ISO)
vinclozolin  (EXP)
vorinostat  (ISO)
xylitol  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Neuronal differentiation of adult rat hippocampus-derived neural stem cells transplanted into embryonic rat explanted retinas with retinoic acid pretreatment. Akita J, etal., Brain Res. 2002 Nov 8;954(2):286-93.
2. Effect of hypothyroidism on the expression of three microtubule-associated proteins (1A, 1B and 2) in developing rat cerebellum. Benjamin S, etal., Neuroscience. 1988 Dec;27(3):931-9.
3. Agrin induced morphological and structural changes in growth cones of cultured hippocampal neurons. Bergstrom RA, etal., Neuroscience. 2007 Nov 9;149(3):527-36. Epub 2007 Aug 14.
4. Microtubule-associated protein 1B-light chain 1 enhances activation of Rap1 by exchange protein activated by cyclic AMP but not intracellular targeting. Borland G, etal., Mol Pharmacol. 2006 Jan;69(1):374-84. Epub 2005 Oct 21.
5. Attenuation of microtubule-associated protein 1B expression by antisense oligodeoxynucleotides inhibits initiation of neurite outgrowth. Brugg B, etal., Neuroscience. 1993 Feb;52(3):489-96.
6. MAP-1B/TAU functional redundancy during laminin-enhanced axonal growth. DiTella MC, etal., J Cell Sci. 1996 Feb;109 ( Pt 2):467-77.
7. Neuronal abnormalities in microtubule-associated protein 1B mutant mice. Edelmann W, etal., Proc Natl Acad Sci U S A 1996 Feb 6;93(3):1270-5.
8. Bilateral growth-related protein expression suggests a transient increase in regenerative potential following brain trauma. Emery DL, etal., J Comp Neurol. 2000 Aug 28;424(3):521-31.
9. Regenerating sciatic nerve axons contain the adult rather than the embryonic pattern of microtubule associated proteins. Fawcett JW, etal., Neuroscience. 1994 Aug;61(4):789-804.
10. Synaptic plasticity is preserved in the temporal cortex of 20-month-old rats. Fischer B and Wagner AP, Arch Gerontol Geriatr. 1997 Jul-Aug;25(1):27-39.
11. Intracerebral injection of AMPA causes axonal damage in vivo. Fowler JH, etal., Brain Res. 2003 Nov 21;991(1-2):104-12.
12. Microtubule-associated protein 1B: a neuronal binding partner for myelin-associated glycoprotein. Franzen R, etal., J Cell Biol. 2001 Dec 10;155(6):893-8. Epub 2001 Dec 3.
13. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
14. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
15. Regulation of phosphorylation of neuronal microtubule-associated proteins MAP1b and MAP2 by protein phosphatase-2A and -2B in rat brain. Gong CX, etal., Brain Res. 2000 Jan 24;853(2):299-309.
16. Maternal protein restriction early in rat pregnancy alters brain development in the progeny. Gressens P, etal., Brain Res Dev Brain Res. 1997 Oct 20;103(1):21-35.
17. MAP2 Defines a Pre-axonal Filtering Zone to Regulate KIF1- versus KIF5-Dependent Cargo Transport in Sensory Neurons. Gumy LF, etal., Neuron. 2017 Apr 19;94(2):347-362.e7. doi: 10.1016/j.neuron.2017.03.046.
18. Localization of microtubule-associated protein (MAP) 1B in the postsynaptic densities of the rat cerebral cortex. Kawakami S, etal., Cell Mol Neurobiol. 2003 Dec;23(6):887-94.
19. Direct interaction and functional coupling between human 5-HT6 receptor and the light chain 1 subunit of the microtubule-associated protein 1B (MAP1B-LC1). Kim SH, etal., PLoS One. 2014 Mar 10;9(3):e91402. doi: 10.1371/journal.pone.0091402. eCollection 2014.
20. Changes in the subcellular distribution of microtubule-associated protein 1B during synaptogenesis of cultured rat cortical neurons. Kitamura C, etal., Cell Mol Neurobiol. 2007 Feb;27(1):57-73. Epub 2006 Dec 7.
21. BMP enhances transcriptional responses to NGF during PC12 cell differentiation. Lonn P, etal., Neurochem Res. 2005 Jun-Jul;30(6-7):753-65.
22. Differential regulation of microtubule-associated protein 1B (MAP1B) in rat CNS and PNS during development. Ma D, etal., J Neurosci Res. 1997 Aug 1;49(3):319-32.
23. Regulation of the expression and phosphorylation of microtubule-associated protein 1B during regeneration of adult dorsal root ganglion neurons. Ma D, etal., Neuroscience. 2000;99(1):157-70.
24. Molecular characterization of light chain 3. A microtubule binding subunit of MAP1A and MAP1B. Mann SS and Hammarback JA, J Biol Chem 1994 Apr 15;269(15):11492-7.
25. Agrin differentially regulates the rates of axonal and dendritic elongation in cultured hippocampal neurons. Mantych KB and Ferreira A, J Neurosci. 2001 Sep 1;21(17):6802-9.
26. Distribution and gene expression of cytoskeletal proteins in two-cell rat embryos and developmental arrest. Matsumoto H, etal., J Exp Zool. 2002 Dec 1;293(7):641-8.
27. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
28. Different postischemic protein expression of the GABA(A) receptor alpha2 subunit and the plasticity-associated protein MAP1B after treatment with BDNF versus G-CSF in the rat brain. Muller HD, etal., Restor Neurol Neurosci. 2009;27(1):27-39.
29. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
30. Microtubule-associated protein 1A (MAP1A) and MAP1B: light chains determine distinct functional properties. Noiges R, etal., J Neurosci 2002 Mar 15;22(6):2106-14.
31. Neuronal loss and cytoskeletal disruption following intrahippocampal administration of the metabolic inhibitor malonate: lack of protection by MK-801. Pang Z, etal., J Neurochem. 1996 Feb;66(2):474-84.
32. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
33. GOA pipeline RGD automated data pipeline
34. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
35. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
36. Inhibition of extension outgrowth in differentiating rat C6 glioma cells by chlorpyrifos and chlorpyrifos oxon: effects on microtubule proteins. Sachana M, etal., Toxicol In Vitro. 2008 Aug;22(5):1387-91. Epub 2008 Mar 18.
37. Kindling status in sprague-dawley rats induced by pentylenetetrazole: involvement of a critical development period. Schmoll H, etal., Am J Pathol. 2003 Mar;162(3):1027-34.
38. Dynamics of gene expression for immediate early- and late genes after seizure activity in aged rats. Schmoll H, etal., Arch Gerontol Geriatr. 2001 Jun;32(3):199-218.
39. MAP 1A and MAP 1B are structurally related microtubule associated proteins with distinct developmental patterns in the CNS. Schoenfeld TA, etal., J Neurosci. 1989 May;9(5):1712-30.
40. Estrogen-induced changes in the microtubular system correlate with a decreased susceptibility of aging neurons to beta amyloid neurotoxicity. Shah RD, etal., Mol Cell Neurosci. 2003 Oct;24(2):503-16.
41. Segment-specific decrease of both catecholamine concentration and acetylcholinesterase activity are accompanied by nerve refinement in the rat cauda epididymis during sexual maturation. Silva AM, etal., J Androl. 2002 May-Jun;23(3):374-83.
42. Extensive structural remodeling of the injured spinal cord revealed by phosphorylated MAP1B in sprouting axons and degenerating neurons. Soares S, etal., Eur J Neurosci. 2007 Sep;26(6):1446-61.
43. Angiotensin II and NGF differentially influence microtubule proteins in PC12W cells: role of the AT2 receptor. Stroth U, etal., Brain Res Mol Brain Res. 1998 Jan;53(1-2):187-95.
44. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
45. Dynamic Palmitoylation Targets MAP6 to the Axon to Promote Microtubule Stabilization during Neuronal Polarization. Tortosa E, etal., Neuron. 2017 May 17;94(4):809-825.e7. doi: 10.1016/j.neuron.2017.04.042.
46. Panaxynol induces neurite outgrowth in PC12D cells via cAMP- and MAP kinase-dependent mechanisms. Wang ZJ, etal., Chem Biol Interact. 2006 Jan 5;159(1):58-64. Epub 2005 Oct 10.
47. Specific binding of acidic phospholipids to microtubule-associated protein MAP1B regulates its interaction with tubulin. Yamauchi E, etal., J Biol Chem. 1997 Sep 5;272(36):22948-53.
48. Identification of two distinct microtubule binding domains on recombinant rat MAP 1B. Zauner W, etal., Eur J Cell Biol 1992 Feb;57(1):66-74.
Additional References at PubMed
PMID:2555150   PMID:8666295   PMID:8889548   PMID:9615228   PMID:11029282   PMID:11581286   PMID:11891784   PMID:12060780   PMID:12270035   PMID:12376528   PMID:12477932   PMID:15090053  
PMID:15277470   PMID:15731007   PMID:15737742   PMID:16536727   PMID:16641100   PMID:16854843   PMID:16855020   PMID:16885219   PMID:17114649   PMID:17704770   PMID:18063656   PMID:19549690  
PMID:19567321   PMID:19616629   PMID:19805073   PMID:21508097   PMID:21700703   PMID:22033417   PMID:22120110   PMID:22169499   PMID:22779921   PMID:22871113   PMID:23300879   PMID:24625528  
PMID:24664738   PMID:25002582   PMID:25483588   PMID:25788676   PMID:28904092   PMID:29476059   PMID:30914445   PMID:31686426   PMID:32357304   PMID:35352799  


Genomics

Comparative Map Data
Map1b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8232,551,423 - 32,644,471 (-)NCBIGRCr8
mRatBN7.2230,817,261 - 30,910,458 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl230,817,261 - 30,910,317 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx237,887,269 - 37,980,116 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0235,981,626 - 36,074,463 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0230,785,607 - 30,878,656 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0229,675,391 - 29,768,750 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl229,675,391 - 29,768,750 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0248,837,124 - 48,930,483 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4230,415,235 - 30,508,354 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1230,339,919 - 30,360,389 (-)NCBI
Celera226,841,920 - 26,934,955 (-)NCBICelera
Cytogenetic Map2q12NCBI
MAP1B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38572,107,475 - 72,209,565 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl572,107,234 - 72,209,565 (+)EnsemblGRCh38hg38GRCh38
GRCh37571,403,302 - 71,505,392 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36571,438,874 - 71,541,153 (+)NCBINCBI36Build 36hg18NCBI36
Build 34571,515,074 - 71,538,609NCBI
Celera567,298,553 - 67,400,783 (+)NCBICelera
Cytogenetic Map5q13.2NCBI
HuRef566,608,550 - 66,710,969 (+)NCBIHuRef
CHM1_1570,835,805 - 70,938,065 (+)NCBICHM1_1
T2T-CHM13v2.0572,588,652 - 72,690,733 (+)NCBIT2T-CHM13v2.0
Map1b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391399,557,972 - 99,653,110 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1399,557,954 - 99,653,048 (-)EnsemblGRCm39 Ensembl
GRCm381399,421,464 - 99,516,602 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1399,421,446 - 99,516,540 (-)EnsemblGRCm38mm10GRCm38
MGSCv3713100,191,419 - 100,286,557 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3613100,524,598 - 100,616,697 (-)NCBIMGSCv36mm8
Celera13103,077,104 - 103,171,785 (-)NCBICelera
Cytogenetic Map13D1NCBI
cM Map1352.9NCBI
Map1b
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955575913,723 - 1,021,028 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955575914,607 - 1,020,971 (+)NCBIChiLan1.0ChiLan1.0
MAP1B
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2443,104,167 - 43,206,535 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1541,257,795 - 41,360,140 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0543,102,739 - 43,204,978 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1543,701,530 - 43,803,393 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl543,701,530 - 43,803,393 (-)Ensemblpanpan1.1panPan2
MAP1B
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1255,175,000 - 55,258,160 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl255,174,837 - 55,253,975 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha252,143,740 - 52,226,846 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0255,691,610 - 55,774,703 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl255,691,446 - 55,771,854 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1252,751,922 - 52,834,958 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0253,519,445 - 53,602,504 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0254,410,527 - 54,493,742 (+)NCBIUU_Cfam_GSD_1.0
Map1b
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213186,487,418 - 186,592,600 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365494,266,351 - 4,371,644 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365494,266,371 - 4,371,579 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MAP1B
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1648,403,568 - 48,498,885 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11648,403,338 - 48,501,453 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21652,391,814 - 52,489,652 (+)NCBISscrofa10.2Sscrofa10.2susScr3
MAP1B
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1466,445,687 - 66,548,595 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl466,445,901 - 66,549,142 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604915,202,185 - 15,305,303 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Map1b
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046249051,198,205 - 1,304,309 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046249051,198,157 - 1,304,128 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Map1b
825 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:570
Count of miRNA genes:277
Interacting mature miRNAs:358
Transcripts:ENSRNOT00000023460
Prediction methods:Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
10755430Coatc6Coat color QTL 60.02576coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)21159110056591100Rat
7387318Stl32Serum triglyceride level QTL 323.20.0003blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)22238462767384627Rat
631682Bp115Blood pressure QTL 1154.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2137410502Rat
10755434Coatc7Coat color QTL 70.04794coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)23064806575648065Rat
10755499Bp389Blood pressure QTL 3892.61arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)218960362228801039Rat
738010Lnnr3Liver neoplastic nodule remodeling QTL 32.94liver integrity trait (VT:0010547)liver remodeling tumorous lesion number (CMO:0001461)2141244106Rat
1358917Cm42Cardiac mass QTL 422.82heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
1300160Hrtrt3Heart rate QTL 33.62heart pumping trait (VT:2000009)absolute change in heart rate (CMO:0000534)22997159351729300Rat
731167Glom4Glomerulus QTL 42.40.0082kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)22030467265304672Rat
1358913Cm41Cardiac mass QTL 412.73heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
738012Anxrr3Anxiety related response QTL 33.8exploratory behavior trait (VT:0010471)percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)2902351954023519Rat
1302794Stl27Serum triglyceride level QTL 274.40.0001blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)225413423143657569Rat
10402051Gdil2Gastrointestinal dilation QTL 2enteric ganglion morphology trait (VT:0001045)length of intestine affected by colonic aganglionosis to total length of colon ratio (CMO:0001836)22490385374786777Rat
9590095Sffal3Serum free fatty acids level QTL 36.780.001blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)22715716072157160Rat
1331764Bp205Blood pressure QTL 2053.476arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)22699957143154682Rat
1358901Cm38Cardiac mass QTL 382heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423157142209Rat
1600379Mcs18Mammary carcinoma susceptibility QTL 182.6mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)2788777242804738Rat
1358899Kidm23Kidney mass QTL 233.88kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1643006Pain1Pain QTL 13.630.005mechanical nociception trait (VT:0002734)self mutilation severity score (CMO:0002145)22699957148268661Rat
1358908Bw49Body weight QTL 493.36body mass (VT:0001259)body weight (CMO:0000012)225413652157142078Rat
1358910Kidm27Kidney mass QTL 275.77kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
61355Bp36Blood pressure QTL 362.9blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)25873687102844969Rat
2300168Bmd47Bone mineral density QTL 476.60.0001femur mineral mass (VT:0010011)bone mineral density (CMO:0001226)22066244865662448Rat
1358911Kidm28Kidney mass QTL 285.42kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358904Cm39Cardiac mass QTL 392.26heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423157142209Rat
1354617Bp240Blood pressure QTL 2404arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)22691781781754745Rat
1578664Bmd9Bone mineral QTL density 95femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)21185206249003364Rat
1357990Ael1Aortic elastin QTL 13.10.00091aorta elastin amount (VT:0003905)aortic elastin21907682564076825Rat
1358887Bw50Body weight QTL 502.39body mass (VT:0001259)body weight (CMO:0000012)225413652157142078Rat
2290453Scl55Serum cholesterol level QTL 552.83blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)226917817136917119Rat
152025206Hrtrt23Heart rate QTL 235.98heart pumping trait (VT:2000009)228484589169504100Rat
1358894Kidm24Kidney mass QTL 244.03kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
731184Mamtr4Mammary tumor resistance QTL 40.0003mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)21649174061491740Rat
152025204Hrtrt22Heart rate QTL 225.6heart pumping trait (VT:2000009)228484589169504100Rat
1354603Bp243Blood pressure QTL 2433.9arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)226917817127469484Rat

Markers in Region
X51396  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2230,820,649 - 30,820,753 (+)MAPPERmRatBN7.2
Rnor_6.0229,678,780 - 29,678,883NCBIRnor6.0
Rnor_5.0248,840,513 - 48,840,616UniSTSRnor5.0
RGSC_v3.4230,418,624 - 30,418,727UniSTSRGSC3.4
Celera226,845,309 - 26,845,412UniSTS
Cytogenetic Map2q12UniSTS
Mtap1b  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2230,910,018 - 30,910,198 (+)MAPPERmRatBN7.2
Rnor_6.0229,768,452 - 29,768,631NCBIRnor6.0
Rnor_5.0248,930,185 - 48,930,364UniSTSRnor5.0
RGSC_v3.4230,508,056 - 30,508,235UniSTSRGSC3.4
Celera226,934,657 - 26,934,836UniSTS
Cytogenetic Map2q12UniSTS
RH137448  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2230,896,129 - 30,896,339 (+)MAPPERmRatBN7.2
Rnor_6.0229,754,567 - 29,754,776NCBIRnor6.0
Rnor_5.0248,916,300 - 48,916,509UniSTSRnor5.0
RGSC_v3.4230,494,171 - 30,494,380UniSTSRGSC3.4
Celera226,920,770 - 26,920,979UniSTS
Cytogenetic Map2q12UniSTS
UniSTS:143928  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2230,826,822 - 30,827,027 (+)MAPPERmRatBN7.2
Rnor_6.0229,684,953 - 29,685,157NCBIRnor6.0
Rnor_5.0248,846,686 - 48,846,890UniSTSRnor5.0
RGSC_v3.4230,424,797 - 30,425,001UniSTSRGSC3.4
Celera226,851,483 - 26,851,687UniSTS
Cytogenetic Map2q12UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_019217 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039101889 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AA925503 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF035827 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF078778 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF079778 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC158858 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BF286433 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BG378086 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BG665276 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CA503854 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CA510735 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CA510940 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CB576609 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CB579120 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CB580055 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CB583564 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CB584802 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CB610210 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CB810012 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CF977184 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473955 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CO393350 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ214081 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000002 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U52950 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X16623 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X60370 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000023460   ⟹   ENSRNOP00000023460
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl230,817,261 - 30,910,317 (-)Ensembl
Rnor_6.0 Ensembl229,675,391 - 29,768,750 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000103521   ⟹   ENSRNOP00000082357
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl230,817,279 - 30,910,317 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000113536   ⟹   ENSRNOP00000079012
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl230,817,261 - 30,910,317 (-)Ensembl
RefSeq Acc Id: NM_019217   ⟹   NP_062090
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8232,551,423 - 32,644,471 (-)NCBI
mRatBN7.2230,817,261 - 30,910,317 (-)NCBI
Rnor_6.0229,675,391 - 29,768,750 (-)NCBI
Rnor_5.0248,837,124 - 48,930,483 (-)NCBI
RGSC_v3.4230,415,235 - 30,508,354 (-)RGD
Celera226,841,920 - 26,934,955 (-)RGD
Sequence:
RefSeq Acc Id: XM_039101889   ⟹   XP_038957817
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8232,551,441 - 32,579,474 (-)NCBI
mRatBN7.2230,817,279 - 30,845,316 (-)NCBI
RefSeq Acc Id: NP_062090   ⟸   NM_019217
- UniProtKB: Q9QW92 (UniProtKB/Swiss-Prot),   Q9ER21 (UniProtKB/Swiss-Prot),   Q62958 (UniProtKB/Swiss-Prot),   F1LRL9 (UniProtKB/Swiss-Prot),   B0BNK3 (UniProtKB/Swiss-Prot),   P15205 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSRNOP00000023460   ⟸   ENSRNOT00000023460
RefSeq Acc Id: XP_038957817   ⟸   XM_039101889
- Peptide Label: isoform X1
- UniProtKB: Q9QW92 (UniProtKB/Swiss-Prot),   Q9ER21 (UniProtKB/Swiss-Prot),   Q62958 (UniProtKB/Swiss-Prot),   P15205 (UniProtKB/Swiss-Prot),   F1LRL9 (UniProtKB/Swiss-Prot),   B0BNK3 (UniProtKB/Swiss-Prot),   A6I569 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000082357   ⟸   ENSRNOT00000103521
Ensembl Acc Id: ENSRNOP00000079012   ⟸   ENSRNOT00000113536

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P15205-F1-model_v2 AlphaFold P15205 1-2461 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13691098
Promoter ID:EPDNEW_R1623
Type:multiple initiation site
Name:Map1b_1
Description:microtubule-associated protein 1B
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0229,768,644 - 29,768,704EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3043 AgrOrtholog
BioCyc Gene G2FUF-54697 BioCyc
Ensembl Genes ENSRNOG00000017428 Ensembl, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00065022186 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000023460.6 UniProtKB/Swiss-Prot
  ENSRNOT00000103521.1 UniProtKB/TrEMBL
  ENSRNOT00000113536.1 UniProtKB/TrEMBL
  ENSRNOT00065037811 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7930451 IMAGE-MGC_LOAD
InterPro MAP1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MAP1B_neuraxin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:29456 UniProtKB/Swiss-Prot
MGC_CLONE MGC:188411 IMAGE-MGC_LOAD
NCBI Gene 29456 ENTREZGENE
PANTHER PTHR13843 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR13843:SF5 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam MAP1B_neuraxin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Map1b PhenoGen
PROSITE MAP1B_NEURAXIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000017428 RatGTEx
  ENSRNOG00065022186 RatGTEx
TIGR TC228428
  TC228522
UniProt A0A8I5ZMJ9_RAT UniProtKB/TrEMBL
  A0A8I5ZWW4_RAT UniProtKB/TrEMBL
  A6I568_RAT UniProtKB/TrEMBL
  A6I569 ENTREZGENE, UniProtKB/TrEMBL
  A6I570_RAT UniProtKB/TrEMBL
  B0BNK3 ENTREZGENE
  F1LRL9 ENTREZGENE
  MAP1B_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q62958 ENTREZGENE
  Q9ER21 ENTREZGENE
  Q9QW92 ENTREZGENE
UniProt Secondary B0BNK3 UniProtKB/Swiss-Prot
  F1LRL9 UniProtKB/Swiss-Prot
  Q62958 UniProtKB/Swiss-Prot
  Q9ER21 UniProtKB/Swiss-Prot
  Q9QW92 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-08-29 Map1b  microtubule-associated protein 1B  Mtap1b  microtubule-associated protein 1B  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-07-21 Mtap1b  microtubule-associated protein 1B  Map1b  microtubule-associated protein 1b  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Map1b  microtubule-associated protein 1b      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_domains contains two seperate microtubule binding domains one of which consists of basic repeat motif KKEE(I/V) 69879