Khk (ketohexokinase) - Rat Genome Database

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Gene: Khk (ketohexokinase) Rattus norvegicus
Analyze
Symbol: Khk
Name: ketohexokinase
RGD ID: 2966
Description: Enables ketohexokinase activity. Involved in several processes, including response to hexose; response to insulin; and response to sucrose. Predicted to be located in nucleus. Predicted to be active in cytosol. Human ortholog(s) of this gene implicated in essential fructosuria. Orthologous to human KHK (ketohexokinase); PARTICIPATES IN fructose and mannose metabolic pathway; fructosuria pathway; hereditary fructose intolerance syndrome pathway; INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: hepatic fructokinase; KETHPRO
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8631,165,246 - 31,175,779 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl631,165,248 - 31,175,481 (-)EnsemblGRCr8
mRatBN7.2625,445,298 - 25,455,834 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl625,445,300 - 25,455,717 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx625,745,610 - 25,755,833 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0626,061,474 - 26,071,697 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0625,540,659 - 25,550,901 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0626,810,577 - 26,821,013 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl626,810,579 - 26,820,959 (-)Ensemblrn6Rnor6.0
Rnor_5.0636,626,192 - 36,636,617 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4625,428,263 - 25,438,497 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera624,935,944 - 24,946,180 (-)NCBICelera
RGSC_v3.1625,431,217 - 25,441,313 (-)NCBI
Cytogenetic Map6q14NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
(1->4)-beta-D-glucan  (ISO)
1,1-dichloroethene  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (ISO)
2,3',4,4',5-Pentachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3-chloropropane-1,2-diol  (EXP)
4-hydroxyphenyl retinamide  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP)
7,9-dihydro-1H-purine-2,6,8(3H)-trione  (EXP,ISO)
acetamide  (EXP)
afimoxifene  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
amitrole  (EXP)
ammonium chloride  (EXP)
aristolochic acid A  (ISO)
arsenous acid  (ISO)
atorvastatin calcium  (EXP)
ATP  (ISO)
benzo[a]pyrene  (ISO)
Benzo[k]fluoranthene  (ISO)
bisphenol A  (EXP,ISO)
butanal  (ISO)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
carbon nanotube  (ISO)
chlorotoluron  (ISO)
chromium trinitrate  (ISO)
chromium(6+)  (ISO)
cisplatin  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
copper(II) sulfate  (ISO)
cyclosporin A  (ISO)
cyproconazole  (ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (EXP)
dimethyl sulfoxide  (ISO)
dioxygen  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
enilconazole  (ISO)
ethanol  (ISO)
fenthion  (ISO)
fructose  (EXP,ISO)
glafenine  (EXP)
gold atom  (ISO)
gold(0)  (ISO)
lead diacetate  (ISO)
leflunomide  (EXP)
lipopolysaccharide  (ISO)
methimazole  (EXP)
N-nitrosodiethylamine  (EXP)
N-nitrosomorpholine  (EXP)
nimesulide  (EXP)
nitrates  (ISO)
O-methyleugenol  (ISO)
okadaic acid  (ISO)
paracetamol  (EXP,ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP)
pirinixic acid  (ISO)
potassium chromate  (ISO)
reactive oxygen species  (ISO)
rotenone  (EXP)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 431542  (ISO)
sodium arsenite  (EXP,ISO)
sodium dichromate  (EXP)
sulfadimethoxine  (EXP)
sunitinib  (ISO)
tetrachloroethene  (ISO)
tetrachloromethane  (ISO)
thimerosal  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
trichloroethene  (EXP)
trovafloxacin  (ISO)
urethane  (ISO)
valdecoxib  (EXP)
valproic acid  (ISO)
vancomycin  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IBA,IEA,ISO)
cytosol  (ISO)
nucleus  (ISO)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Zinc inhibition of hepatic fructose metabolism in rats. Coyle P, etal., Biol Trace Elem Res. 2003 Apr;92(1):41-54.
2. Expression of rat liver ketohexokinase in yeast results in fructose intolerance. Donaldson IA, etal., Biochem J 1993 Apr 1;291 ( Pt 1):179-86.
3. Effect of aging on changes in substrate and effector levels of rat-liver glycolytic and lipogenic enzymes during induction. Fukuda H and Iritani N, Biochim Biophys Acta. 1984 Aug 15;795(1):79-84.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
6. Structure and alternative splicing of the ketohexokinase gene. Hayward BE and Bonthron DT, Eur J Biochem 1998 Oct 1;257(1):85-91.
7. ChREBP-Knockout Mice Show Sucrose Intolerance and Fructose Malabsorption. Kato T, etal., Nutrients. 2018 Mar 12;10(3). pii: nu10030340. doi: 10.3390/nu10030340.
8. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
9. Dietary fructose induces a wide range of genes with distinct shift in carbohydrate and lipid metabolism in fed and fasted rat liver. Koo HY, etal., Biochim Biophys Acta. 2008 May;1782(5):341-8. Epub 2008 Feb 29.
10. Ketohexokinase C blockade ameliorates fructose-induced metabolic dysfunction in fructose-sensitive mice. Lanaspa MA, etal., J Clin Invest. 2018 Jun 1;128(6):2226-2238. doi: 10.1172/JCI94427. Epub 2018 Apr 23.
11. Ketohexokinase knockout mice, a model for essential fructosuria, exhibit altered fructose metabolism and are protected from diet-induced metabolic defects. Miller CO, etal., Am J Physiol Endocrinol Metab. 2018 Sep 1;315(3):E386-E393. doi: 10.1152/ajpendo.00027.2018. Epub 2018 Jun 5.
12. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
13. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
14. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
15. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
16. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
17. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
18. Comprehensive gene review and curation RGD comprehensive gene curation
19. Response of hepatic fructokinase to long-term sucrose diets and diabetes in spiny mice, albino mice and rats. Shafrir E and Orevi M, Comp Biochem Physiol B. 1984;78(2):493-8.
20. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
21. Localization of 54 rat genes, and definition of new synteny groups conserved in the human and the rat. Szpirer C, etal., Mamm Genome 2000 Sep;11(9):729-35
22. Effects of diet on rat intestinal soluble hexokinase and fructokinase activities. Weiser MM, etal., Am J Physiol. 1971 Sep;221(3):844-9.
Additional References at PubMed
PMID:12941785   PMID:15489334   PMID:15652177   PMID:16465401   PMID:19056867   PMID:19237742   PMID:19365088   PMID:20841500   PMID:21115336   PMID:21122807   PMID:22371574   PMID:23376485  


Genomics

Comparative Map Data
Khk
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8631,165,246 - 31,175,779 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl631,165,248 - 31,175,481 (-)EnsemblGRCr8
mRatBN7.2625,445,298 - 25,455,834 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl625,445,300 - 25,455,717 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx625,745,610 - 25,755,833 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0626,061,474 - 26,071,697 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0625,540,659 - 25,550,901 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0626,810,577 - 26,821,013 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl626,810,579 - 26,820,959 (-)Ensemblrn6Rnor6.0
Rnor_5.0636,626,192 - 36,636,617 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4625,428,263 - 25,438,497 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera624,935,944 - 24,946,180 (-)NCBICelera
RGSC_v3.1625,431,217 - 25,441,313 (-)NCBI
Cytogenetic Map6q14NCBI
KHK
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38227,086,772 - 27,100,762 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl227,086,723 - 27,100,777 (+)Ensemblhg38GRCh38
GRCh37227,309,640 - 27,323,630 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36227,163,115 - 27,177,123 (+)NCBIBuild 36Build 36hg18NCBI36
Build 34227,221,770 - 27,235,252NCBI
Celera227,155,955 - 27,169,965 (+)NCBICelera
Cytogenetic Map2p23.3NCBI
HuRef227,051,765 - 27,065,924 (+)NCBIHuRef
CHM1_1227,239,525 - 27,253,535 (+)NCBICHM1_1
T2T-CHM13v2.0227,128,445 - 27,142,438 (+)NCBIT2T-CHM13v2.0
Khk
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39531,078,780 - 31,088,592 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl531,078,775 - 31,088,592 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38530,921,436 - 30,931,248 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl530,921,431 - 30,931,248 (+)Ensemblmm10GRCm38
MGSCv37531,224,268 - 31,233,619 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36531,198,476 - 31,207,827 (+)NCBIMGSCv36mm8
Celera528,401,689 - 28,411,041 (+)NCBICelera
Cytogenetic Map5B1NCBI
cM Map516.9NCBI
Khk
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554699,058,095 - 9,071,091 (+)Ensembl
ChiLan1.0NW_0049554699,058,095 - 9,071,091 (+)NCBIChiLan1.0ChiLan1.0
KHK
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21299,415,724 - 99,428,805 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12A99,419,692 - 99,432,773 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02A27,085,758 - 27,099,768 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12A27,174,896 - 27,189,308 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A27,174,896 - 27,189,308 (+)EnsemblpanPan2panpan1.1
KHK
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11721,079,907 - 21,092,510 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1721,079,907 - 21,092,510 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1720,971,570 - 20,984,321 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01721,399,371 - 21,413,177 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1721,399,398 - 21,413,176 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11721,086,630 - 21,099,927 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01721,097,714 - 21,111,029 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01721,144,127 - 21,157,862 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Khk
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629265,384,457 - 65,395,298 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364935,441,165 - 5,455,176 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049364935,444,284 - 5,455,100 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
KHK
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl3112,021,108 - 112,031,620 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.13112,021,163 - 112,031,615 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.23119,019,718 - 119,030,168 (-)NCBISscrofa10.2Sscrofa10.2susScr3
KHK
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11480,518,049 - 80,531,643 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1480,514,825 - 80,531,653 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604531,608,128 - 31,621,763 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Khk
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247389,189,320 - 9,202,053 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247389,189,343 - 9,205,209 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Khk
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1723,151,921 - 23,161,786 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Khk
26 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:44
Count of miRNA genes:42
Interacting mature miRNAs:44
Transcripts:ENSRNOT00000043572
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
8552962Pigfal16Plasma insulin-like growth factor 1 level QTL 169.4blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)6197587946975879Rat
10401812Kidm54Kidney mass QTL 54kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)62009763565097635Rat
8552910Pigfal5Plasma insulin-like growth factor 1 level QTL 54.3blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)62265388967653889Rat
10401800Kidm49Kidney mass QTL 49kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)62009763565097635Rat
1300164Rf15Renal function QTL 153.12renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)6323998948239989Rat
9589129Insul24Insulin level QTL 2419.060.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)6197587946975879Rat
7411603Foco13Food consumption QTL 135.50.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)6197587946975879Rat
1598843Cm63Cardiac mass QTL 632.6heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)6144788383Rat
7411542Bw127Body weight QTL 1275.50.001body mass (VT:0001259)body weight gain (CMO:0000420)6197587946975879Rat
2292616Ept15Estrogen-induced pituitary tumorigenesis QTL 154.4pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)6144788383Rat
9589048Scfw3Subcutaneous fat weight QTL 34.570.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)6197587946975879Rat
2293839Kiddil2Kidney dilation QTL 24.8kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)62661831486868070Rat
1576309Emca7Estrogen-induced mammary cancer QTL 74mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)620859430113082285Rat
2301964Bp323Blood pressure QTL 3234.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)6186868070Rat
2293709Bss23Bone structure and strength QTL 235.180.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)6323998948239989Rat
2293650Bss31Bone structure and strength QTL 315.050.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)6323998948239989Rat
2293841Kiddil4Kidney dilation QTL 44.4kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)62661831486868070Rat
1300128Rf16Renal function QTL 163.89renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)6140163351Rat
1641898Colcr4Colorectal carcinoma resistance QTL43.710.0007intestine integrity trait (VT:0010554)well differentiated malignant colorectal tumor surface area measurement (CMO:0002077)63093763275937632Rat
70199Coreg1Compensatory renal growth QTL 111.8kidney mass (VT:0002707)compensatory renal growth score (CMO:0001894)61459947363457687Rat
2301972Bp325Blood pressure QTL 3254.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)61608937261967788Rat
1358190Ept1Estrogen-induced pituitary tumorigenesis QTL 14.4pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)6144788383Rat
2293656Bss28Bone structure and strength QTL 286.790.0001femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)6323998948239989Rat
1359023Bp272Blood pressure QTL 2722.5arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)62228825732981219Rat
1354664Slep2Serum leptin concentration QTL 24.49blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)62228825767288257Rat

Markers in Region
RH131913  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2625,456,093 - 25,456,273 (+)MAPPERmRatBN7.2
Rnor_6.0626,821,369 - 26,821,548NCBIRnor6.0
Rnor_5.0636,636,984 - 36,637,163UniSTSRnor5.0
RGSC_v3.4625,439,055 - 25,439,234UniSTSRGSC3.4
Celera624,946,738 - 24,946,917UniSTS
RH 3.4 Map691.7UniSTS
Cytogenetic Map6q14UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 164 91 90 59 92 59 6 356 192 11 143 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000043572   ⟹   ENSRNOP00000046296
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl631,165,248 - 31,175,481 (-)Ensembl
mRatBN7.2 Ensembl625,445,300 - 25,455,717 (-)Ensembl
Rnor_6.0 Ensembl626,810,579 - 26,820,959 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000104499   ⟹   ENSRNOP00000081407
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl631,165,248 - 31,175,481 (-)Ensembl
mRatBN7.2 Ensembl625,445,300 - 25,455,536 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000114876   ⟹   ENSRNOP00000095511
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl631,165,248 - 31,175,481 (-)Ensembl
mRatBN7.2 Ensembl625,445,302 - 25,455,450 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000136952   ⟹   ENSRNOP00000106101
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl631,165,248 - 31,175,230 (-)Ensembl
RefSeq Acc Id: NM_031855   ⟹   NP_114061
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8631,165,246 - 31,175,481 (-)NCBI
mRatBN7.2625,445,298 - 25,455,536 (-)NCBI
Rnor_6.0626,810,577 - 26,820,811 (-)NCBI
Rnor_5.0636,626,192 - 36,636,617 (-)NCBI
RGSC_v3.4625,428,263 - 25,438,497 (-)RGD
Celera624,935,944 - 24,946,180 (-)RGD
Sequence:
RefSeq Acc Id: XM_006239790   ⟹   XP_006239852
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8631,165,246 - 31,175,779 (-)NCBI
mRatBN7.2625,445,298 - 25,455,834 (-)NCBI
Rnor_6.0626,810,577 - 26,821,012 (-)NCBI
Rnor_5.0636,626,192 - 36,636,617 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017594047   ⟹   XP_017449536
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8631,165,246 - 31,175,779 (-)NCBI
mRatBN7.2625,445,298 - 25,455,834 (-)NCBI
Rnor_6.0626,810,577 - 26,821,010 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017594048   ⟹   XP_017449537
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8631,165,246 - 31,175,779 (-)NCBI
mRatBN7.2625,445,298 - 25,455,834 (-)NCBI
Rnor_6.0626,810,577 - 26,821,013 (-)NCBI
Sequence:
RefSeq Acc Id: NP_114061   ⟸   NM_031855
- UniProtKB: P97550 (UniProtKB/Swiss-Prot),   P97551 (UniProtKB/Swiss-Prot),   Q02974 (UniProtKB/Swiss-Prot),   A6HAB0 (UniProtKB/TrEMBL),   A0A8L2QMK2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006239852   ⟸   XM_006239790
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_017449537   ⟸   XM_017594048
- Peptide Label: isoform X3
- UniProtKB: A0A8I6G7X9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017449536   ⟸   XM_017594047
- Peptide Label: isoform X2
- Sequence:
Ensembl Acc Id: ENSRNOP00000046296   ⟸   ENSRNOT00000043572
Ensembl Acc Id: ENSRNOP00000081407   ⟸   ENSRNOT00000104499
Ensembl Acc Id: ENSRNOP00000095511   ⟸   ENSRNOT00000114876
Ensembl Acc Id: ENSRNOP00000106101   ⟸   ENSRNOT00000136952
Protein Domains
Carbohydrate kinase PfkB

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q02974-F1-model_v2 AlphaFold Q02974 1-298 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13694454
Promoter ID:EPDNEW_R4977
Type:initiation region
Name:Khk_1
Description:ketohexokinase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R4978  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0626,820,678 - 26,820,738EPDNEW
RGD ID:13694456
Promoter ID:EPDNEW_R4978
Type:initiation region
Name:Khk_2
Description:ketohexokinase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R4977  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0626,820,960 - 26,821,020EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2966 AgrOrtholog
BioCyc Gene G2FUF-38334 BioCyc
BioCyc Pathway PWY66-373 [sucrose degradation V (sucrose alpha-glucosidase)] BioCyc
BioCyc Pathway Image PWY66-373 BioCyc
Ensembl Genes ENSRNOG00000008047 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000043572 ENTREZGENE
  ENSRNOT00000104499 ENTREZGENE
  ENSRNOT00000114876 ENTREZGENE
Gene3D-CATH 3.40.1190.20 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7109062 IMAGE-MGC_LOAD
InterPro Ketohexokinase-related UniProtKB/Swiss-Prot
  KHK UniProtKB/Swiss-Prot
  PfkB_dom UniProtKB/Swiss-Prot
  Ribokinase-like UniProtKB/Swiss-Prot
KEGG Report rno:25659 UniProtKB/Swiss-Prot
MGC_CLONE MGC:93239 IMAGE-MGC_LOAD
NCBI Gene 25659 ENTREZGENE
PANTHER PFKB-LIKE CARBOHYDRATE KINASE FAMILY PROTEIN UniProtKB/Swiss-Prot
  PHOSPHOTRANSFERASE SYSTEM TRANSPORT PROTEIN UniProtKB/Swiss-Prot
Pfam PfkB UniProtKB/Swiss-Prot
PhenoGen Khk PhenoGen
RatGTEx ENSRNOG00000008047 RatGTEx
Superfamily-SCOP SSF53613 UniProtKB/Swiss-Prot
UniProt A0A8I6AMT1_RAT UniProtKB/TrEMBL
  A0A8I6G7X9 ENTREZGENE, UniProtKB/TrEMBL
  A0A8L2QMK2 ENTREZGENE, UniProtKB/TrEMBL
  A6HAA9 ENTREZGENE, UniProtKB/TrEMBL
  A6HAB0 ENTREZGENE, UniProtKB/TrEMBL
  KHK_RAT UniProtKB/Swiss-Prot
  P97550 ENTREZGENE
  P97551 ENTREZGENE
  Q02974 ENTREZGENE
UniProt Secondary P97550 UniProtKB/Swiss-Prot
  P97551 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Khk  Ketohexokinase      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_protein 299 amino acids 633105
gene_transcript transcript consists of two alternatively spliced forms 633104