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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2966 Species: Rattus norvegicus RGD Object: Gene Symbol: Khk Name: ketohexokinase

Acc ID: CHEBI:28757 Term: fructose Definition: null CasRN: 30237-26-4 Chemical ID: MESH:D005632

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
multiple interactions	ISO	RGD:69145	6480464	CTD	KHK protein promotes the reaction [Fructose results in decreased abundance of Adenosine Triphosphate] KHK protein promotes the reaction [Fructose results in increased abundance of Reactive Oxygen Species] KHK protein promotes the reaction [Fructose results in increased secretion of CCL2 protein]	PMID:19158351
multiple interactions	ISO	RGD:10837	6480464	CTD	Fructose results in increased expression of and results in increased activity of KHK protein	PMID:18395287
increases expression	ISO	RGD:10837	6480464	CTD	Fructose results in increased expression of KHK mRNA	PMID:15066988
increases expression	EXP		6480464	CTD	Fructose results in increased expression of KHK mRNA	PMID:18346472
multiple interactions	EXP		6480464	CTD	atorvastatin inhibits the reaction [Fructose results in increased expression of KHK protein]	PMID:21122807
increases expression	EXP		6480464	CTD	Fructose results in increased expression of KHK protein	PMID:21122807