Advanced Search (OLGA)

Gene: Kcnn3 (potassium calcium-activated channel subfamily N member 3) Rattus norvegicus

Analyze

Symbol:

Kcnn3

Name:

potassium calcium-activated channel subfamily N member 3

RGD ID:

2964

Description:

Enables small conductance calcium-activated potassium channel activity. Involved in potassium ion transport. Located in filopodium; neuromuscular junction; and neuronal cell body. Human ortholog(s) of this gene implicated in paranoid schizophrenia and schizophrenia. Orthologous to human KCNN3 (potassium calcium-activated channel subfamily N member 3); PARTICIPATES IN calcium/calcium-mediated signaling pathway; schizophrenia pathway; INTERACTS WITH (+)-pilocarpine; 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

KCa2.3; potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 3; potassium intermediate/small conductance calcium-activated channel, subfamily N, member 3; SK3; SKCa 3; SKCa3; small conductance calcium-activated potassium channel protein 3; small-conductance Ca2+-activated K+ channel 3

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	2	177,227,276 - 177,378,849 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	2	177,234,327 - 177,379,693 (+)	Ensembl				GRCr8
mRatBN7.2	2	174,929,846 - 175,088,910 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	2	174,936,629 - 175,081,145 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	2	182,082,045 - 182,226,480 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	2	180,104,430 - 180,248,869 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	2	174,705,175 - 174,849,783 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	2	188,837,280 - 188,991,794 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	2	188,844,073 - 188,988,774 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	2	208,267,083 - 208,411,812 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	2	181,715,888 - 181,860,459 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	2	168,877,193 - 169,021,955 (+)	NCBI		Celera
RGSC_v3.1	2	181,665,999 - 181,810,563 (+)	NCBI
Cytogenetic Map	2	q34	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

atrial fibrillation (ISO)

genetic disease (ISO)

paranoid schizophrenia (ISO)

prostate cancer (ISO)

schizophrenia (ISO)

Zimmermann-Laband Syndrome 3 (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(+)-pilocarpine (EXP)

1-Ethyl-2-benzimidazolinone (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

6-propyl-2-thiouracil (EXP)

acetamide (EXP)

acrylamide (ISO)

aflatoxin B1 (ISO)

Aflatoxin B2 alpha (ISO)

all-trans-retinoic acid (ISO)

alpha-Zearalanol (EXP)

ammonium chloride (EXP)

benzo[a]pyrene (ISO)

benzo[e]pyrene (ISO)

bis(2-ethylhexyl) phthalate (EXP,ISO)

bisphenol A (EXP,ISO)

Butylbenzyl phthalate (ISO)

C60 fullerene (EXP)

calcium atom (ISO)

calcium(0) (ISO)

chlorpyrifos (ISO)

copper(II) sulfate (ISO)

Cuprizon (EXP)

decabromodiphenyl ether (EXP)

dibutyl phthalate (EXP)

dorsomorphin (ISO)

doxorubicin (ISO)

ethanol (ISO)

ethyl methanesulfonate (ISO)

flavonoids (EXP)

fulvestrant (ISO)

ionomycin (EXP)

lipopolysaccharide (ISO)

methapyrilene (ISO)

methoxychlor (EXP)

methylmercury chloride (ISO)

niclosamide (ISO)

ozone (ISO)

panobinostat (ISO)

paracetamol (EXP,ISO)

perfluorooctanoic acid (EXP)

phenylmercury acetate (ISO)

propanal (ISO)

rotenone (EXP)

S-(1,2-dichlorovinyl)-L-cysteine (ISO)

SB 431542 (ISO)

silicon dioxide (EXP,ISO)

sodium arsenite (ISO)

Soman (EXP)

sunitinib (ISO)

tetrachloromethane (EXP)

thallium atom (EXP,ISO)

trichloroethene (EXP)

valproic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

monoatomic ion transmembrane transport (IEA)

monoatomic ion transport (IEA)

potassium ion transmembrane transport (IBA,IEA,ISO)

potassium ion transport (IEA,IMP)

Cellular Component

cell body (IDA)

cytoplasm (IEA,ISO)

filopodium (IDA)

membrane (IEA)

neuromuscular junction (IDA)

neuron projection (IBA)

neuronal cell body (IBA,IDA)

plasma membrane (IBA,IEA,ISO)

Z disc (IEA)

Molecular Function

calcium-activated potassium channel activity (IEA)

calmodulin binding (IBA,IEA,ISO)

inward rectifier potassium channel activity (IEA,ISO)

protein binding (ISO)

protein-containing complex binding (IMP)

small conductance calcium-activated potassium channel activity (IBA,IEA,IMP,ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

calcium/calcium-mediated signaling pathway (ISO)

schizophrenia pathway (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Small-conductance Ca2+-activated K+ channels: form and function.	Adelman JP, etal., Annu Rev Physiol. 2012;74:245-69. doi: 10.1146/annurev-physiol-020911-153336. Epub 2011 Sep 19.
2.	Cloning and functional expression of a liver isoform of the small conductance Ca2+-activated K+ channel SK3.	Barfod ET, etal., Am J Physiol Cell Physiol 2001 Apr;280(4):C836-42.
3.	Further support for an association between a polymorphic CAG repeat in the hKCa3 gene and schizophrenia.	Bowen T, etal., Mol Psychiatry 1998 May;3(3):266-9.
4.	Expression of Ca(2+)-activated K(+) channels, SK3, in the interstitial cells of Cajal in the gastrointestinal tract.	Fujita A, etal., Am J Physiol Cell Physiol 2001 Nov;281(5):C1727-33.
5.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6.	SK3 is an important component of K(+) channels mediating the afterhyperpolarization in cultured rat SCG neurones.	Hosseini R, etal., J Physiol 2001 Sep 1;535(Pt 2):323-34.
7.	Small-conductance, calcium-activated potassium channels from mammalian brain.	Kohler M, etal., Science 1996 Sep 20;273(5282):1709-14.
8.	Formation of cellular projections in neural progenitor cells depends on SK3 channel activity.	Liebau S, etal., J Neurochem. 2007 Jun;101(5):1338-1350.
9.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
10.	The SK3 subunit of small conductance Ca2+-activated K+ channels interacts with both SK1 and SK2 subunits in a heterologous expression system.	Monaghan AS, etal., J Biol Chem 2004 Jan 9;279(2):1003-9. Epub 2003 Oct 14.
11.	The distribution of small and intermediate conductance calcium-activated potassium channels in the rat sensory nervous system.	Mongan LC, etal., Neuroscience. 2005;131(1):161-75.
12.	Electronic Transfer of LocusLink and RefSeq Data	NCBI rat LocusLink and RefSeq merged data July 26, 2002
13.	Distribution, expression and functional effects of small conductance Ca-activated potassium (SK) channels in rat myometrium.	Noble K, etal., Cell Calcium. 2010 Jan;47(1):47-54. doi: 10.1016/j.ceca.2009.11.004. Epub 2009 Dec 6.
14.	GOA pipeline	RGD automated data pipeline
15.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
16.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
17.	An association of CAG repeats at the KCNN3 locus with symptom dimensions of schizophrenia.	Ritsner M, etal., Biol Psychiatry 2002 May 15;51(10):788-94.
18.	Presynaptic localization of the small conductance calcium-activated potassium channel SK3 at the neuromuscular junction.	Roncarati R, etal., Neuroscience. 2001;104(1):253-62.

Additional References at PubMed

PMID:14638680	PMID:15170822	PMID:16055520	PMID:16134141	PMID:16627563	PMID:17167222	PMID:18703580	PMID:19254702	PMID:20364152	PMID:20369552	PMID:20662937	PMID:21464958
PMID:23129791	PMID:23966325	PMID:24096910	PMID:24270810	PMID:24505302	PMID:25096234	PMID:25148577	PMID:28342809	PMID:29038048	PMID:29952429	PMID:30361965	PMID:31155282
PMID:34233598

Genomics

Comparative Map Data

Kcnn3
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	2	177,227,276 - 177,378,849 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	2	177,234,327 - 177,379,693 (+)	Ensembl				GRCr8
mRatBN7.2	2	174,929,846 - 175,088,910 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	2	174,936,629 - 175,081,145 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	2	182,082,045 - 182,226,480 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	2	180,104,430 - 180,248,869 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	2	174,705,175 - 174,849,783 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	2	188,837,280 - 188,991,794 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	2	188,844,073 - 188,988,774 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	2	208,267,083 - 208,411,812 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	2	181,715,888 - 181,860,459 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	2	168,877,193 - 169,021,955 (+)	NCBI		Celera
RGSC_v3.1	2	181,665,999 - 181,810,563 (+)	NCBI
Cytogenetic Map	2	q34	NCBI

KCNN3
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	1	154,697,455 - 154,870,281 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	1	154,697,455 - 154,870,281 (-)	Ensembl			hg38	GRCh38
GRCh37	1	154,669,931 - 154,842,757 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	1	152,946,526 - 153,109,378 (-)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	1	151,492,989 - 151,645,411	NCBI
Celera	1	127,751,520 - 127,913,779 (-)	NCBI		Celera
Cytogenetic Map	1	q21.3	NCBI
HuRef	1	126,060,322 - 126,204,704 (-)	NCBI		HuRef
HuRef	1	126,032,908 - 126,048,980 (-)	NCBI		HuRef
CHM1_1	1	156,066,361 - 156,239,140 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	1	153,834,568 - 154,009,637 (-)	NCBI		T2T-CHM13v2.0

Kcnn3
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	3	89,427,471 - 89,579,801 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	3	89,427,471 - 89,582,439 (+)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	3	89,520,164 - 89,672,494 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	3	89,520,164 - 89,675,132 (+)	Ensembl			mm10	GRCm38
MGSCv37	3	89,324,086 - 89,476,416 (+)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	3	89,606,348 - 89,753,332 (+)	NCBI		MGSCv36	mm8
Celera	3	89,555,070 - 89,707,910 (+)	NCBI		Celera
Cytogenetic Map	3	F1	NCBI
cM Map	3	39.16	NCBI

Kcnn3
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955545	1,216,650 - 1,374,270 (-)	Ensembl
ChiLan1.0	NW_004955545	1,212,240 - 1,374,189 (-)	NCBI	ChiLan1.0	ChiLan1.0

KCNN3
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	1	94,970,096 - 95,142,009 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	1	94,702,198 - 94,873,844 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	1	130,052,903 - 130,218,977 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	1	133,666,849 - 133,828,679 (-)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	1	133,666,876 - 133,828,366 (-)	Ensembl			panPan2	panpan1.1

KCNN3
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	7	42,562,500 - 42,704,862 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	7	42,572,432 - 42,698,047 (+)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	7	42,063,572 - 42,196,588 (+)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	7	42,442,589 - 42,575,584 (+)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	7	42,442,641 - 42,568,405 (+)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	7	42,222,259 - 42,355,157 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	7	42,275,911 - 42,408,933 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	7	42,559,462 - 42,692,483 (+)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Kcnn3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405058	25,240,985 - 25,395,768 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936580	4,277,217 - 4,426,493 (-)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936580	4,277,219 - 4,426,242 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

KCNN3
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	4	94,915,965 - 95,113,275 (+)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	4	94,913,631 - 95,112,845 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	4	103,700,718 - 103,872,900 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

KCNN3
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	20	8,961,833 - 9,124,728 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	20	8,962,302 - 9,124,166 (+)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666038	8,298,278 - 8,463,050 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Kcnn3
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624885	2,597,466 - 2,726,363 (+)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624885	2,597,605 - 2,731,598 (+)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Kcnn3
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	3	64,000,188 - 64,149,496 (-)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Kcnn3
8470 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	33
Count of miRNA genes:	28
Interacting mature miRNAs:	32
Transcripts:	ENSRNOT00000028117
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1358356	Srcrt1	Stress Responsive Cort QTL1	3.66		blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	2	163997722	225110681	Rat
1578648	Bss11	Bone structure and strength QTL 11	4.7		femur morphology trait (VT:0000559)	femoral neck cortical cross-sectional area (CMO:0001702)	2	169358774	214358774	Rat
1331734	Bp204	Blood pressure QTL 204	3.61192		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	2	170656145	239614549	Rat
631566	Bp90	Blood pressure QTL 90		0.0001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	149957381	221199885	Rat
1298074	Bp164	Blood pressure QTL 164		0.003	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	44537979	205135428	Rat
1354648	Bp239	Blood pressure QTL 239		0.001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	67845370	229470703	Rat
1354649	Kidm17	Kidney mass QTL 17	2.9		kidney mass (VT:0002707)	calculated kidney weight (CMO:0000160)	2	83465462	229820014	Rat
10755499	Bp389	Blood pressure QTL 389	2.61		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	2	20695736	231474293	Rat
1298076	Bp166	Blood pressure QTL 166		0.0009	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	138595962	205135428	Rat
1581576	Pur7	Proteinuria QTL 7		0.0001	urine total protein amount (VT:0000032)	urine total protein excretion rate (CMO:0000756)	2	80396178	220931218	Rat
61457	Niddm8	Non-insulin dependent diabetes mellitus QTL 8	4.1	0.01	blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	2	176840779	178247591	Rat
152025245	Scl81	Serum cholesterol level QTL 81	3.49		blood cholesterol amount (VT:0000180)		2	124537199	209621565	Rat
1581578	Cm49	Cardiac mass QTL 49	4.9	0.01	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	2	145807215	220931416	Rat
631198	Cm22	Cardiac mass QTL 22	4.3	0.0008	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	2	78269809	208420281	Rat
1554319	Bmd2	Bone mineral density QTL 2	13.4	0.0001	lumbar vertebra area (VT:0010570)	lumbar vertebra cross-sectional area (CMO:0001689)	2	122597372	215234002	Rat
12879836	Kidm61	Kidney mass QTL 61		0.001	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	2	154723085	199723085	Rat
1581569	Uae32	Urinary albumin excretion QTL 32		0.0001	urine protein amount (VT:0005160)	urine albumin excretion rate (CMO:0000757)	2	80396178	220931218	Rat
10043136	Iddm54	Insulin dependent diabetes mellitus QTL 54	3.4	0.0001	blood glucose amount (VT:0000188)	age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)	2	145807215	190807215	Rat
12879837	Am2	Aortic mass QTL 2		0.001	aorta mass (VT:0002845)	aorta weight to aorta length to body weight ratio (CMO:0002722)	2	154723085	199723085	Rat
10043139	Iddm55	Insulin dependent diabetes mellitus QTL 55	3.1	0.0001	blood glucose amount (VT:0000188)	age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)	2	150313808	195313808	Rat
12879838	Cm86	Cardiac mass QTL 86		0.002	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	2	154723085	199723085	Rat
1302793	Bw16	Body weight QTL 16	5	0.0001	body mass (VT:0001259)	body weight (CMO:0000012)	2	159440891	205135267	Rat
12879839	Cm85	Cardiac mass QTL 85		0.001	heart mass (VT:0007028)	heart wet weight to body weight ratio (CMO:0002408)	2	154723085	199723085	Rat
1549833	Bp257	Blood pressure QTL 257		0.003	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	2	170652929	215652929	Rat
1358900	Bw48	Body weight QTL 48	4.88		body mass (VT:0001259)	body weight (CMO:0000012)	2	159440891	220931218	Rat
4889834	Pur24	Proteinuria QTL 24	5.8	0.014	urine total protein amount (VT:0000032)	urine total protein excretion rate (CMO:0000756)	2	171994826	205135428	Rat
12879845	Cm89	Cardiac mass QTL 89		0.008	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	2	154723085	178247591	Rat
61473	Bp19	Blood pressure QTL 19	6.3		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	175008837	178247591	Rat
1359030	Bp277	Blood pressure QTL 277			arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	2	143565208	188565208	Rat
12879846	Cm90	Cardiac mass QTL 90		0.011	heart right ventricle mass (VT:0007033)	heart right ventricle weight to body weight ratio (CMO:0000914)	2	154723085	178247591	Rat
12879847	Am4	Aortic mass QTL 4		0.001	aorta mass (VT:0002845)	aorta weight to aorta length to body weight ratio (CMO:0002722)	2	154723085	178247591	Rat
1331760	Bp206	Blood pressure QTL 206	3.62454		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	2	4265106	205135428	Rat
12879840	Bw179	Body weight QTL 179		0.005	body mass (VT:0001259)	body weight (CMO:0000012)	2	154723085	199723085	Rat
1581502	Esta3	Estrogen-induced thymic atrophy QTL 3			thymus mass (VT:0004954)	thymus wet weight (CMO:0000855)	2	139067258	192287892	Rat
1359032	Hrtrt18	Heart rate QTL 18			heart pumping trait (VT:2000009)	heart rate (CMO:0000002)	2	159440760	195313808	Rat
2301966	Bp322	Blood pressure QTL 322	3.58		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	144882354	205135428	Rat
1298080	Bp163	Blood pressure QTL 163		0.02	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	67845182	205135428	Rat
1357991	Ael2	Aortic elastin QTL 2	4.2	0.000071	aorta elastin amount (VT:0003905)	aortic elastin	2	169227906	214227906	Rat
8662832	Vetf7	Vascular elastic tissue fragility QTL 7	3.5		aorta elastin amount (VT:0003905)	aorta wall extracellular elastin dry weight to aorta wall dry weight ratio (CMO:0002002)	2	83400752	223709938	Rat
1298085	Bp165	Blood pressure QTL 165		0.0006	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	44537979	205135428	Rat
1578671	Bmd10	Bone mineral density QTL 10	5.4		femur mineral mass (VT:0010011)	compact volumetric bone mineral density (CMO:0001730)	2	175931416	220931416	Rat
1359022	Ppulsi1	Prepulse inhibition QTL 1	3.63		prepulse inhibition trait (VT:0003088)	acoustic startle response measurement (CMO:0001519)	2	139067258	184067258	Rat
1641891	Alcrsp17	Alcohol response QTL 17			response to alcohol trait (VT:0010489)	duration of loss of righting reflex (CMO:0002289)	2	151869660	251712708	Rat
724534	Uae6	Urinary albumin excretion QTL 6	10		urine albumin amount (VT:0002871)	urine albumin level (CMO:0000130)	2	80396034	220931416	Rat
61374	Edpm2	Estrogen-dependent pituitary mass QTL 2	4.42	0.86	pituitary gland mass (VT:0010496)	pituitary gland wet weight (CMO:0000853)	2	78269809	205135428	Rat
8662843	Vetf9	Vascular elastic tissue fragility QTL 9	2.05		thoracic aorta molecular composition trait (VT:0010568)	aorta wall extracellular elastin dry weight to aorta wall extracellular collagen weight ratio (CMO:0002003)	2	159440760	228950743	Rat
2301415	Cm67	Cardiac mass QTL 67		0.003	heart mass (VT:0007028)	heart wet weight to body weight ratio (CMO:0002408)	2	154723085	178247591	Rat
1331794	Bp202	Blood pressure QTL 202	3.66819		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	143344967	251712708	Rat
71113	Cari2	Carrageenan-induced inflammation QTL 2	2.7	0.009	hypodermis integrity trait (VT:0010550)	inflammatory exudate volume (CMO:0001429)	2	143746578	205135428	Rat
1331805	Cm29	Cardiac mass QTL 29	3.50746		heart mass (VT:0007028)	heart wet weight (CMO:0000069)	2	143344967	251712708	Rat
11565180	Kidm56	Kidney mass QTL 56		0.003	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	2	154723085	178247591	Rat
634308	Sach6	Saccharin preference QTL 6	4.9		taste sensitivity trait (VT:0001986)	saccharin intake volume to total fluid intake volume ratio (CMO:0001601)	2	114384617	215381366	Rat
1598805	Memor8	Memory QTL 8	3		exploratory behavior trait (VT:0010471)	average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)	2	150096616	195096616	Rat
11565181	Bw176	Body weight QTL 176		0.002	body mass (VT:0001259)	body weight (CMO:0000012)	2	154723085	178247591	Rat
1358917	Cm42	Cardiac mass QTL 42	2.82		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	2	27148328	206613235	Rat
724568	Uae13	Urinary albumin excretion QTL 13	4.4		urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	2	145306936	212705578	Rat
1358913	Cm41	Cardiac mass QTL 41	2.73		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	2	27148328	206613235	Rat
1300165	Rf9	Renal function QTL 9	3.28		kidney glomerulus integrity trait (VT:0010546)	index of glomerular damage (CMO:0001135)	2	113746222	205135428	Rat
61401	Niddm2	Non-insulin dependent diabetes mellitus QTL 2	4.54		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	2	147287892	192287892	Rat
631507	Bp105	Blood pressure QTL 105		0.001	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	2	114384617	215381366	Rat
1641925	Alcrsp2	Alcohol response QTL 2			response to alcohol trait (VT:0010489)	duration of loss of righting reflex (CMO:0002289)	2	151869660	223841096	Rat
1354609	Niddm62	Non-insulin dependent diabetes mellitus QTL 62	4.72	0.000006	insulin secretion trait (VT:0003564)	plasma insulin level (CMO:0000342)	2	117415288	205135428	Rat
1598833	Bp295	Blood pressure QTL 295	3.5		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	150096616	195096616	Rat
1354622	Kidm16	Kidney mass QTL 16	3		kidney mass (VT:0002707)	left kidney wet weight (CMO:0000083)	2	83465462	225110681	Rat
631266	Bp132	Blood pressure QTL 132		0.0005	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	47856345	205135428	Rat
631522	Bp74	Blood pressure QTL 74		0.05	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	175008837	220008837	Rat
7488927	Bp365	Blood pressure QTL 365		0.008	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	2	165453811	210453811	Rat
7488925	Bp364	Blood pressure QTL 364		0.001	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	2	163253030	208253030	Rat
2293843	Kiddil6	Kidney dilation QTL 6	3.1		kidney pelvis morphology trait (VT:0004194)	hydronephrosis severity score (CMO:0001208)	2	44537979	184731399	Rat
2306901	Bp337	Blood pressure QTL 337		0.01	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	166372086	229820014	Rat
1354605	Rf48	Renal function QTL 48	2.9		blood creatinine amount (VT:0005328)	plasma creatinine level (CMO:0000537)	2	76328396	209350714	Rat
7488904	Bp363	Blood pressure QTL 363		0.001	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	2	175279960	178247591	Rat

Markers in Region

D2Wox58

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	2	174,936,981 - 174,937,201 (+)	MAPPER	mRatBN7.2
Rnor_6.0	2	188,844,457 - 188,844,676	NCBI	Rnor6.0
Rnor_5.0	2	208,267,436 - 208,267,655	UniSTS	Rnor5.0
RGSC_v3.4	2	181,716,241 - 181,716,460	UniSTS	RGSC3.4
Celera	2	168,877,546 - 168,877,765	UniSTS
Cytogenetic Map	2	q34	UniSTS

G16005

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	2	174,937,074 - 174,937,326 (+)	MAPPER	mRatBN7.2
Rnor_6.0	2	188,844,550 - 188,844,801	NCBI	Rnor6.0
Rnor_5.0	2	208,267,529 - 208,267,780	UniSTS	Rnor5.0
RGSC_v3.4	2	181,716,334 - 181,716,585	UniSTS	RGSC3.4
Celera	2	168,877,639 - 168,877,890	UniSTS
Cytogenetic Map	2	q34	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
16	12	67	153	63	62	31	79	31	6	307	179	11	132	73	92	31	11	11

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_019315	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017591053	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039102986	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063282418	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC128343	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AC133222	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AF284345	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AF292389	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473976	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	DQ137428	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000002	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	U69884	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000028117 ⟹ ENSRNOP00000028117

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	2	177,234,327 - 177,379,693 (+)	Ensembl
mRatBN7.2 Ensembl	2	174,936,629 - 175,081,145 (+)	Ensembl
Rnor_6.0 Ensembl	2	188,844,073 - 188,988,774 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000128529 ⟹ ENSRNOP00000104004

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	2	177,234,436 - 177,379,693 (+)	Ensembl

RefSeq Acc Id:

NM_019315 ⟹ NP_062188

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	2	177,234,340 - 177,378,849 (+)	NCBI
mRatBN7.2	2	174,936,629 - 175,081,155 (+)	NCBI
Rnor_6.0	2	188,844,104 - 188,988,598 (+)	NCBI
Rnor_5.0	2	208,267,083 - 208,411,812 (+)	NCBI
RGSC_v3.4	2	181,715,888 - 181,860,459 (+)	RGD
Celera	2	168,877,193 - 169,021,955 (+)	RGD

Sequence:

show sequence

GGCACGAGGTGAAGCTGAGTCTGCCTCATTCACTCCTAGAGGACCGCCTTCAGAATAGAGTTCT
TTTCGCCCCTTCCTCCTTCTCCCAGCTCCTCTCCTGGCTTTTCTATCCGCCCAATACAATGCAC
ACTCGAGTGGCAGCCCCAGAGAACTGAAGCAAACCAAAGAGAGAGGACTGGAGCCAAGACACTT
CTGGTGGGGAAGCTTGGATGCCTGGCTTTCTTTGAGGTCATCTTTGGAACGAGGGTGGCTTTGG
GGTGGAGGGTCGTGCTGCAGGGAACCCAGCCAGGCCCCAAGATGGACACTTCTGGGCACTTCCA
TGACTCGGGGGTGGGGGATCTGGATGAAGACCCCAAGTGTCCCTGTCCATCTTCTGGGGACGAG
CAACAGCAGCAACAGCAACCGCCACCACCGTCAGCGCCACCAGCAGTCCCCCAGCAGCCTCCGG
GACCCTTGCTGCAGCCTCAGCCTCCGCAGCTTCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCA
GCAGCAGCAGCAGCAGCAGCAGCAGGCTCCACTGCACCCCCTGCCTCAGCTTGCCCAACTCCAG
AGCCAGCTTGTCCATCCTGGTCTGTTGCACTCTTCTCCCACGGCTTTCAGGGCTCCCAATTCAG
CCAACTCCACCGCCATCCTCCACCCTTCCTCCAGGCAAGGCAGCCAGCTAAATCTCAATGACCA
CTTGCTTGGCCACTCTCCAAGTTCCACAGCCACAAGTGGGCCTGGTGGAGGCAGCCGGCACCGG
CAGGCCAGCCCCCTGGTGCACCGGCGGGACAGCAATCCCTTCACGGAGATAGCTATGAGCTCCT
GCAAATACAGCGGTGGGGTCATGAAGCCCCTCAGCCGCCTCAGCGCCTCTCGGAGAAACCTTAT
CGAGGCCGAACCTGAGGGCCAACCCCTACAGCTCTTCAGTCCCAGCAACCCCCCAGAGATTATC
ATCTCCTCCAGGGAGGATAACCATGCCCACCAGACTCTGCTCCATCACCCCAACGCTACCCACA
ACCACCAGCATGCCGGCACCACTGCTGGCAGCACCACCTTCCCCAAAGCCAACAAGCGGAAAAA
CCAAAACATTGGCTATAAGCTGGGGCACAGGAGGGCCCTGTTTGAAAAGAGAAAGCGACTGAGT
GACTATGCTCTGATTTTTGGGATGTTTGGAATTGTTGTTATGGTGATAGAGACCGAACTGTCTT
GGGGTTTGTACTCAAAGGATTCCATGTTTTCGTTGGCCCTGAAATGCCTTATCAGTTTATCCAC
CATCATCCTGCTTGGTTTGATCATCGCCTACCACACAAGGGAAGTACAGCTCTTTGTGATCGAC
AATGGTGCAGATGACTGGCGGATAGCCATGACCTATGAGCGCATCCTCTACATCAGCCTGGAGA
TGCTGGTGTGCGCCATCCACCCCATTCCTGGAGAGTACAAGTTCTTCTGGACGGCACGCCTGGC
CTTCTCCTACACCCCCTCTCGGGCAGAGGCTGACGTGGACATTATTCTGTCCATCCCCATGTTC
TTGCGCCTATACCTGATCGCCCGAGTCATGCTGCTACATAGCAAGCTCTTCACGGATGCCTCAT
CCCGAAGCATCGGGGCCCTCAACAAGATCAACTTCAACACCCGATTCGTCATGAAGACGCTCAT
GACCATCTGCCCGGGCACGGTGCTGCTGGTGTTCAGCATCTCTCTGTGGATCATCGCTGCCTGG
ACTGTGAGAGTCTGTGAAAGGTACCATGACCAGCAGGACGTAACTAGTAACTTTCTGGGTGCCA
TGTGGCTCATCTCCATCACGTTCCTTTCCATTGGCTATGGGGACATGGTGCCCCACACATACTG
TGGGAAAGGTGTCTGTCTTCTCACTGGCATCATGGGTGCAGGCTGCACTGCCCTCGTGGTAGCT
GTGGTTGCCCGAAAGCTCGAACTCACCAAAGCAGAGAAGCATGTGCACAACTTCATGATGGACA
CTCAGCTCACCAAACGGATCAAGAACGCTGCCGCCAATGTCCTCCGGGAAACATGGCTGATCTA
CAAACACACAAAGCTGCTAAAGAAGATTGACCACGCCAAAGTCAGGAAACACCAGAGGAAGTTC
CTCCAAGCTATTCACCAACTGAGGGGTGTCAAGATGGAACAAAGGAAGCTGAGTGACCAAGCCA
ACACCCTGGTGGACCTTTCCAAGATGCAGAACGTCATGTATGACTTGATCACGGAGCTCAACGA
CCGGAGTGAAGACCTGGAAAAGCAGATTGGCAGCCTGGAATCCAAGCTGGAGCACCTCACAGCC
AGCTTCAATTCCCTGCCCCTGCTCATCGCAGACACCCTGCGCCAACAGCAGCAGCAGCTGCTCA
CTGCCTTCGTGGAGGCCCGGGGCATCAGTGTGGCTGTGGGAACTAGCCACGCCCCTCCCTCTGA
CAGCCCTATCGGGATCAGCTCCACCTCTTTCCCAACCCCATACACAAGTTCAAGCAGTTGCTAA
ATAAAACTCCCCACTCCAGAAAAAAAAAAAAAAAAAAA

hide sequence

RefSeq Acc Id:

XM_017591053 ⟹ XP_017446542

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	2	177,227,292 - 177,378,849 (+)	NCBI
mRatBN7.2	2	174,929,846 - 175,088,910 (+)	NCBI
Rnor_6.0	2	188,837,280 - 188,991,794 (+)	NCBI

Sequence:

show sequence

ACTGCTCCCATCTGGAGTGATTCATCTGTCCAGAACAGTAAGTCCTCACACCGAAGCGCCAGAG
AAGGTTCGTGAGAAGCATTTAATAACGTGTCTTGGTCTTCACAGCCAGCTCTGGCAGAAGACAT
AAGGGTCTGGCTTTGTAAGGATTCCATGTTTTCGTTGGCCCTGAAATGCCTTATCAGTTTATCC
ACCATCATCCTGCTTGGTTTGATCATCGCCTACCACACAAGGGAAGTACAGCTCTTTGTGATCG
ACAATGGTGCAGATGACTGGCGGATAGCCATGACCTATGAGCGCATCCTCTACATCAGCCTGGA
GATGCTGGTGTGCGCCATCCACCCCATTCCTGGAGAGTACAAGTTCTTCTGGACGGCACGCCTG
GCCTTCTCCTACACCCCCTCTCGGGCAGAGGCTGACGTGGACATTATTCTGTCCATCCCCATGT
TCTTGCGCCTATACCTGATCGCCCGAGTCATGCTGCTACATAGCAAGCTCTTCACGGATGCCTC
ATCCCGAAGCATCGGGGCCCTCAACAAGATCAACTTCAACACCCGATTCGTCATGAAGACGCTC
ATGACCATCTGCCCGGGCACGGTGCTGCTGGTGTTCAGCATCTCTCTGTGGATCATCGCTGCCT
GGACTGTGAGAGTCTGTGAAAGGTACCATGACCAGCAGGACGTAACTAGTAACTTTCTGGGTGC
CATGTGGCTCATCTCCATCACGTTCCTTTCCATTGGCTATGGGGACATGGTGCCCCACACATAC
TGTGGGAAAGGTGTCTGTCTTCTCACTGGCATCATGGGTGCAGGCTGCACTGCCCTCGTGGTAG
CTGTGGTTGCCCGAAAGCTCGAACTCACCAAAGCAGAGAAGCATGTGCACAACTTCATGATGGA
CACTCAGCTCACCAAACGGATCAAGAACGCTGCCGCCAATGTCCTCCGGGAAACATGGCTGATC
TACAAACACACAAAGCTGCTAAAGAAGATTGACCACGCCAAAGTCAGGAAACACCAGAGGAAGT
TCCTCCAAGCTATTCACCAACTGAGGGGTGTCAAGATGGAACAAAGGAAGCTGAGTGACCAAGC
CAACACCCTGGTGGACCTTTCCAAGATGCAGAACGTCATGTATGACTTGATCACGGAGCTCAAC
GACCGGAGTGAAGACCTGGAAAAGCAGATTGGCAGCCTGGAATCCAAGCTGGAGCACCTCACAG
CCAGCTTCAATTCCCTGCCCCTGCTCATCGCAGACACCCTGCGCCAACAGCAGCAGCAGCTGCT
CACTGCCTTCGTGGAGGCCCGGGGCATCAGTGTGGCTGTGGGAACTAGCCACGCCCCTCCCTCT
GACAGCCCTATCGGGATCAGCTCCACCTCTTTCCCAACCCCATACACAAGTTCAAGCAGTTGCT
AAATAAAACTCCCCACTCCAGAAGCATTACCCATAGGTCTTAAGATGCAAATCAACTCTCTCCT
GGTCGCTTTGCTGTCAAGGAAGTTTCAGACCAGGGAACAGAACGAAGAGAGATGGAGCGATGAG
CCGACTCATGTTCTTTCAGCGTGCTTTGTTCGATATGCCTTGAAACCAGAAATCTAATCTCTGT
TTAGGTGCCTCTACTTGGGAGCTGGAAGAGGAGGTGACGGGAAGCAACGCCTCTGTCAGGGCCC
TTGCTGCAGAGTTGGCGGAGAACAGAAATCCCTGCTCAATCTCAGGTTTTCACAGGGAGGTGGG
GGAGGGGCAGCCACTCTGAAGCAGAGGAGAGGGAAGCCAGCCAAAGAGGGGTGTGCTGGGCAAG
GGTGGTATGAGGTTTGGGGAATGGGTTCCTGGTTGCCTTGGGACCACAGCACACCTATCCTTTT
GTCTAAGGAAGCCTCTGGGTGGTAAAAATAAAACAGAGCTACCCAGAACTTTCCAAAATGGACA
TACCCAAATTAGACTGGGGAGGAGGGTGATGGAGACAAATAAAAAGCCAGAATTTCCATCCAAT
GATACGATCCAACATATATACACACAGATGTTCAATCCAGGTCCTTTTCTGTTTGAATTGAGCC
CAAATGAAAGGGACCTGGTACTTCGCCTTGCACACAGTAAGCAAGCTCTAATTCCGCATTGAGA
TGATGTGTGGGGTGTGTTTTGTTGAGGAAGTTAGCGGGGATTGGCCATATTCTGAGCTTCACTG
AAGATGCAGGTCCCTCCCTGACAGTGTCCTGGTTACCCATGCTGCCTGATTCAAGTGTAGGCCA
AGCCCGCACTGTTGGCATTGTGGAGAGATAAGCAGCCTTCTAAAAACAAACAAAAACAAAAAAA
AGACAGCTTTTGAAGAATTTTCTCCCAGCCAGATAATCTGTGTGCCCTTGGAACCCACGTTCCC
AGGTGTCTGTGTGTAGGAGAGGAGGAGACAAGTATGCTCAGTGCCCCCATAGTGAACAGGACTG
ATGTCTGGGGCGCTGTCAAAGCATCTTCACCCGGCAGCAGGCTCCGGCCAGACATGTAAGAGTA
CGGAAGGATCAGTGCCTAACCCTGCTAGGTTGGGAGGAGAAGGGTGGGGAGTGGCTCCTGTGGC
CCCTTCTACCTTACCTGACATCATCTCAAAAATGAAACACTGTGAGAACACAAGGCGCCCTAGG
GACACTTGTGTGTAAAGTGAGAGGACACATTTGTTAGAAGCCTGTCCTATTGTGCCACGTTCAT
CTTGGGGTAAAACCTACTCCACTGAATCTCAGACTCCAAGAGACTCCAGAGAGAAGCAGACCCA
GTATAAGGACAGGCACTCCCCACCCCCACCCCCCATTGCTCCGTGATCTGACCGCACACACAGC
CGTGCGGGAGAGCTATTGAGTCACCTCTCATTTCTCCATCCAGAGGTCTTCGATTTCTGCTTAT
AAGAAATTATATGTGGAACATTTCATCTATCTTTTGGTAGGCCCAAAGGACGTTGTCTGTGTAT
AGTTGCTGTCCGGAGAGTAGTCCTGTGGCAGGTTACCACAGCCCCCTGGAGGTATCGCCTTACT
CTGTGCGTTTCTCTTGTGCACTGCTGGGCCTGGTCCTTTCAGGACAGGGAAATTGCTGGACATC
AAGGCAGACAACTGTGGCCTGGAGGACATGCCTTGGTTTTTTGTTTGTTTGTTGCTAAGTCTCT
TGTTTGTCTTTCCGCCTTGCTGCTGCTGTCTGTACCTTGTTTCTGCAGTGCTGGAGAGCAGGCT
CGCGGCTTCCTGCATGTTAGACAAGTGCTGTTCCACTCAACCACACCCCAGCCTACTGCTGTTG
TCTTAATGGCCTATCCTCTTAATGGTCTATCCTGATCGCTCCCTCGAGCATTTTCATTAGCTGT
TTTGCACACCAGAGAGGCCACATTTGTCGTTAGCATTTAATTCTTTTTACTTGTTCTTTTAATT
ATTAATTATCTGAAAGATTATTTTTATCCCGAGAATGGTATCCCTGTTTTCAGTTTGACCGTAC
CTACAGGCAGACGTGCAGACAGAGGAAATAGGCATGTACCTTCTTTGTGTCACTGTTTGCATTT
GACAAAATGAGGGCTGCTGATGGGCCCACCTCCTCGTCATTTGACCTACAGCCCTCAAGTGTTT
CCTCTGCTCTCTGTTGCCGCTTGCTCTGATCCTGTGCTGTGTGGCCATAGCATGGCACCTCTAG
GATTTAGTTCCCATTTCACACAAGTGACACGCAAGATCCCACCACTTCTCCTGCCATGTATCAA
TCCCGGACATAGTCTAAAATCTGTCCTTTTGTTTTTATTCTTGCTTAGTAAACCCTGAAGGCCA
AGCTAGAAATGCTTCAAGAGGATGGCTAGAACTGTTTCAGGAGGGTACCACTAGCATTAGAGAG
ACACATGGGCCTTTGTAGGGTGGCTTGGCCCACTGGTATTGCAATAGGTCTGGGTGGTCTTATT
GTTAGCAAAAGAATCTACCTCGAGAAACGTGACAGGATCAGAAGGCTGGCTCTGTGAGGGTAAA
TGAAGTGCTGCTTCTTCGCCCTACTATTTCCCTAATATGAGGGAAGTGATAATTCTCTTGCAAA
TATATTGACCCTTGATGACCTAGGTATTGAGGACCCTGGCTAGCTCGCCCAGATGTATCCTTGC
ATCTTTTAGATGATCCCATGTCACCTAAGCATCTCAGTTGAGCTAGGAAGGAGGCTAGTGGGTG
CTCAGGCTATGTGGTAGTGGGAGAGGTCTGAGTCTCAGGACTGGGCTGCAATTTAAAACCATGA
ATTACTGTAATTTCGCTCTAGGCCTGAACTGGTCCAGTTCTGCTCACTCCTAGAAGGCTGACCA
GTGACAGAGGCCCTCCTGGCATCTTCCCAGGAATGCAGTAGCAGACAGAAGCACTCCAACATAT
CCCCAAATATCTGGACACTTGAATGAAAACTGTAGAGCCACCGTGTCATTGCTTAAGCCATATT
ACTGCTTCAGGTACTGTGGAGTCAGGGATGCACTGTGATACTCCAAGGCCACTGAGCTCAGTGG
GATTTCAGGACATAGCATCAGTTGGTAATTTACGCCTGACTAGAAGCTCATTTCTCCTTAGATT
GACATCCAAATAAGAATCTGCACCTTTGGCTCAAAGGCCACGTGTGTGATCACCATCAATAAAC
CATCATGAAGTGTTTGTGA

hide sequence

RefSeq Acc Id:

XM_039102986 ⟹ XP_038958914

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	2	177,235,447 - 177,378,849 (+)	NCBI
mRatBN7.2	2	174,938,340 - 175,088,910 (+)	NCBI

RefSeq Acc Id:

XM_063282418 ⟹ XP_063138488

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	2	177,227,276 - 177,378,849 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_062188	(Get FASTA)	NCBI Sequence Viewer
	XP_017446542	(Get FASTA)	NCBI Sequence Viewer
	XP_038958914	(Get FASTA)	NCBI Sequence Viewer
	XP_063138488	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAB81653	(Get FASTA)	NCBI Sequence Viewer
	AAG13967	(Get FASTA)	NCBI Sequence Viewer
	AAG38878	(Get FASTA)	NCBI Sequence Viewer
	AAZ91674	(Get FASTA)	NCBI Sequence Viewer
	EDM00618	(Get FASTA)	NCBI Sequence Viewer
	EDM00619	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000028117
GenBank Protein	P70605	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_062188 ⟸ NM_019315

- UniProtKB:

Q9ERQ4 (UniProtKB/Swiss-Prot), Q9EQ81 (UniProtKB/Swiss-Prot), P70605 (UniProtKB/Swiss-Prot), G3V8S7 (UniProtKB/TrEMBL), A6J6H0 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MDTSGHFHDSGVGDLDEDPKCPCPSSGDEQQQQQQPPPPSAPPAVPQQPPGPLLQPQPPQLQQQ
QQQQQQQQQQQQQQQQAPLHPLPQLAQLQSQLVHPGLLHSSPTAFRAPNSANSTAILHPSSRQG
SQLNLNDHLLGHSPSSTATSGPGGGSRHRQASPLVHRRDSNPFTEIAMSSCKYSGGVMKPLSRL
SASRRNLIEAEPEGQPLQLFSPSNPPEIIISSREDNHAHQTLLHHPNATHNHQHAGTTAGSTTF
PKANKRKNQNIGYKLGHRRALFEKRKRLSDYALIFGMFGIVVMVIETELSWGLYSKDSMFSLAL
KCLISLSTIILLGLIIAYHTREVQLFVIDNGADDWRIAMTYERILYISLEMLVCAIHPIPGEYK
FFWTARLAFSYTPSRAEADVDIILSIPMFLRLYLIARVMLLHSKLFTDASSRSIGALNKINFNT
RFVMKTLMTICPGTVLLVFSISLWIIAAWTVRVCERYHDQQDVTSNFLGAMWLISITFLSIGYG
DMVPHTYCGKGVCLLTGIMGAGCTALVVAVVARKLELTKAEKHVHNFMMDTQLTKRIKNAAANV
LRETWLIYKHTKLLKKIDHAKVRKHQRKFLQAIHQLRGVKMEQRKLSDQANTLVDLSKMQNVMY
DLITELNDRSEDLEKQIGSLESKLEHLTASFNSLPLLIADTLRQQQQQLLTAFVEARGISVAVG
TSHAPPSDSPIGISSTSFPTPYTSSSSC

hide sequence

RefSeq Acc Id:

XP_017446542 ⟸ XM_017591053

- Peptide Label:

isoform X2

- Sequence:

show sequence

MFSLALKCLISLSTIILLGLIIAYHTREVQLFVIDNGADDWRIAMTYERILYISLEMLVCAIHP
IPGEYKFFWTARLAFSYTPSRAEADVDIILSIPMFLRLYLIARVMLLHSKLFTDASSRSIGALN
KINFNTRFVMKTLMTICPGTVLLVFSISLWIIAAWTVRVCERYHDQQDVTSNFLGAMWLISITF
LSIGYGDMVPHTYCGKGVCLLTGIMGAGCTALVVAVVARKLELTKAEKHVHNFMMDTQLTKRIK
NAAANVLRETWLIYKHTKLLKKIDHAKVRKHQRKFLQAIHQLRGVKMEQRKLSDQANTLVDLSK
MQNVMYDLITELNDRSEDLEKQIGSLESKLEHLTASFNSLPLLIADTLRQQQQQLLTAFVEARG
ISVAVGTSHAPPSDSPIGISSTSFPTPYTSSSSC

hide sequence

Ensembl Acc Id:

ENSRNOP00000028117 ⟸ ENSRNOT00000028117

RefSeq Acc Id:	XP_038958914 ⟸ XM_039102986
- Peptide Label:	isoform X2

RefSeq Acc Id:	XP_063138488 ⟸ XM_063282418
- Peptide Label:	isoform X1
- UniProtKB:	Q9ERQ4 (UniProtKB/Swiss-Prot), Q9EQ81 (UniProtKB/Swiss-Prot), P70605 (UniProtKB/Swiss-Prot), A6J6H0 (UniProtKB/TrEMBL), G3V8S7 (UniProtKB/TrEMBL)

Ensembl Acc Id:

ENSRNOP00000104004 ⟸ ENSRNOT00000128529

Protein Domains

Calmodulin-binding

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-P70605-F1-model_v2	AlphaFold	P70605	1-732	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13691480

Promoter ID:

EPDNEW_R2005

Type:

single initiation site

Name:

Kcnn3_1

Description:

potassium calcium-activated channel subfamily N member 3

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	2	188,844,093 - 188,844,153	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:2964	AgrOrtholog
BioCyc Gene	G2FUF-52401	BioCyc
Ensembl Genes	ENSRNOG00000020706	Ensembl, ENTREZGENE
Ensembl Transcript	ENSRNOT00000028117	ENTREZGENE
Gene3D-CATH	1.10.287.70	UniProtKB/Swiss-Prot
InterPro	CaM-bd_dom	UniProtKB/Swiss-Prot
	CaM-bd_dom_sf	UniProtKB/Swiss-Prot
	K_chnl_Ca-activ_SK	UniProtKB/Swiss-Prot
	K_chnl_dom	UniProtKB/Swiss-Prot
KEGG Report	rno:54263	UniProtKB/Swiss-Prot
NCBI Gene	54263	ENTREZGENE
PANTHER	PTHR10153	UniProtKB/Swiss-Prot
Pfam	CaMBD	UniProtKB/Swiss-Prot
	Ion_trans_2	UniProtKB/Swiss-Prot
	SK_channel	UniProtKB/Swiss-Prot
PhenoGen	Kcnn3	PhenoGen
PRINTS	SKCHANNEL	UniProtKB/Swiss-Prot
RatGTEx	ENSRNOG00000020706	RatGTEx
SMART	CaMBD	UniProtKB/Swiss-Prot
Superfamily-SCOP	beta-sandwich domain of Sec23/24	UniProtKB/Swiss-Prot
	SSF81327	UniProtKB/Swiss-Prot
	Voltage-gated potassium channels	UniProtKB/Swiss-Prot
UniProt	A0ABK0L404_RAT	UniProtKB/TrEMBL
	A6J6H0	ENTREZGENE, UniProtKB/TrEMBL
	A6J6H1_RAT	UniProtKB/TrEMBL
	G3V8S7	ENTREZGENE, UniProtKB/TrEMBL
	KCNN3_RAT	UniProtKB/Swiss-Prot, ENTREZGENE
	Q9EQ81	ENTREZGENE
	Q9ERQ4	ENTREZGENE
UniProt Secondary	Q9EQ81	UniProtKB/Swiss-Prot
	Q9ERQ4	UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2016-02-11	Kcnn3	potassium calcium-activated channel subfamily N member 3	Kcnn3	potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 3	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2015-01-26	Kcnn3	potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 3	Kcnn3	potassium intermediate/small conductance calcium-activated channel, subfamily N, member 3	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2002-06-10	Kcnn3	potassium intermediate/small conductance calcium-activated channel, subfamily N, member 3			Name updated	70584	APPROVED

RGD Curation Notes

Note Type	Note	Reference
gene_cellular_localization	localized to cell bodies and processes of neurons	727322
gene_expression	protein expressed in the interstitial cells of Cajal (ICC), myenteric plexus and muscular layers of the stomach, ileum, and colon; mRNA expressed in the brain	628451
gene_process	may mediate a rhythmic pacemaker current in the gastrointestinal (GI) tract	628451

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

RGD Manual Annotations

Send us a Message

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

RGD Manual Annotations