Kcnj1 (potassium inwardly-rectifying channel, subfamily J, member 1) - Rat Genome Database

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Gene: Kcnj1 (potassium inwardly-rectifying channel, subfamily J, member 1) Rattus norvegicus
Analyze
Symbol: Kcnj1
Name: potassium inwardly-rectifying channel, subfamily J, member 1
RGD ID: 2957
Description: Enables several functions, including ATP-activated inward rectifier potassium channel activity; anion binding activity; and potassium ion binding activity. Involved in several processes, including cellular response to magnesium ion; potassium ion import across plasma membrane; and response to potassium ion. Predicted to be located in membrane. Predicted to be part of monoatomic ion channel complex. Predicted to be active in plasma membrane. Biomarker of nephrotic syndrome. Human ortholog(s) of this gene implicated in Bartter disease type 2. Orthologous to human KCNJ1 (potassium inwardly rectifying channel subfamily J member 1); PARTICIPATES IN aldosterone signaling pathway; INTERACTS WITH (S)-amphetamine; 3-chloropropane-1,2-diol; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: ATP-regulated potassium channel; ATP-regulated potassium channel ROM-K; ATP-sensitive inward rectifier potassium channel 1; inward rectifier K(+) channel Kir1.1; K+ channel protein; KAB-1; Kcnj; Kcnj1_v1; Kcnj1_v3; kir1.1; potassium channel, inwardly rectifying subfamily J member 1; potassium channel, inwardly rectifying subfamily J, member 1; Potassium inwardly-rectifying channel subfamily J; potassium voltage-gated channel subfamily J member 1, variant 1; potassium voltage-gated channel subfamily J member 1, variant 3; ROMK1; ROMK2; ROMK3
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: Kcnj1em1Kasu
Genetic Models: SS-Kcnj1em1Kasu-/- ; SS-Kcnj1em1Kasu+/-
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8839,014,822 - 39,066,716 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl839,037,992 - 39,066,715 (+)EnsemblGRCr8
mRatBN7.2830,779,883 - 30,808,607 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl830,753,617 - 30,813,796 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx834,852,146 - 34,880,732 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0833,146,554 - 33,175,142 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0831,009,408 - 31,038,027 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0833,490,280 - 33,519,127 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl833,514,042 - 33,518,165 (+)Ensemblrn6Rnor6.0
Rnor_5.0833,453,597 - 33,454,750 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4832,158,243 - 32,162,370 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera832,231,456 - 32,260,138 (+)NCBICelera
RGSC_v3.1832,167,008 - 32,171,135 (+)NCBI
Cytogenetic Map8q21NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Splicing of a retained intron within ROMK K+ channel RNA generates a novel set of isoforms in rat kidney. Beesley AH, etal., Am J Physiol 1999 Mar;276(3 Pt 1):C585-92.
2. ROMK inwardly rectifying ATP-sensitive K+ channel. II. Cloning and distribution of alternative forms. Boim MA, etal., Am J Physiol. 1995 Jun;268(6 Pt 2):F1132-40.
3. Molecular basis of ATP-sensitive K+ channels in rat vascular smooth muscles. Cao K, etal., Biochem Biophys Res Commun 2002 Aug 16;296(2):463-9.
4. Heterozygous mutations of the gene for Kir 1.1 (ROMK) in antenatal Bartter syndrome presenting with transient hyperkalemia, evolving to a benign course. Cho JT and Guay-Woodford LM, J Korean Med Sci. 2003 Feb;18(1):65-8.
5. Mutations in the ROMK gene in antenatal Bartter syndrome are associated with impaired K+ channel function. Derst C, etal., Biochem Biophys Res Commun. 1997 Jan 23;230(3):641-5. doi: 10.1006/bbrc.1996.6024.
6. An amino acid triplet in the NH2 terminus of rat ROMK1 determines interaction with SUR2B. Dong K, etal., J Biol Chem 2001 Nov 23;276(47):44347-53.
7. Localization of the ATP/phosphatidylinositol 4,5 diphosphate-binding site to a 39-amino acid region of the carboxyl terminus of the ATP-regulated K+ channel Kir1.1. Dong K, etal., J Biol Chem 2002 Dec 20;277(51):49366-73.
8. Characterization of Kir1.1 channels with the use of a radiolabeled derivative of tertiapin. Felix JP, etal., Biochemistry. 2006 Aug 22;45(33):10129-39.
9. Inhibition of K+ secretion in the distal nephron in nephrotic syndrome: possible role of albuminuria. Fila M, etal., J Physiol. 2011 Jul 15;589(Pt 14):3611-21. doi: 10.1113/jphysiol.2011.209692. Epub 2011 May 23.
10. Mitochondrial ROMK channel is a molecular component of mitoK(ATP). Foster DB, etal., Circ Res. 2012 Aug 3;111(4):446-54. doi: 10.1161/CIRCRESAHA.112.266445. Epub 2012 Jul 17.
11. Effects of dietary K on cell-surface expression of renal ion channels and transporters. Frindt G and Palmer LG, Am J Physiol Renal Physiol. 2010 Oct;299(4):F890-7. doi: 10.1152/ajprenal.00323.2010. Epub 2010 Aug 11.
12. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
13. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
14. Cloning and expression of an inwardly rectifying ATP-regulated potassium channel. Ho K, etal., Nature 1993 Mar 4;362(6415):31-8.
15. Direct activation of inward rectifier potassium channels by PIP2 and its stabilization by Gbetagamma. Huang CL, etal., Nature. 1998 Feb 19;391(6669):803-6. doi: 10.1038/35882.
16. K depletion increases protein tyrosine kinase-mediated phosphorylation of ROMK. Lin DH, etal., Am J Physiol Renal Physiol 2002 Oct;283(4):F671-7.
17. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
18. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
19. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
20. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
21. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
22. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
23. The carboxyl termini of K(ATP) channels bind nucleotides. Vanoye CG, etal., J Biol Chem. 2002 Jun 28;277(26):23260-70. doi: 10.1074/jbc.M112004200. Epub 2002 Apr 15.
24. Magnesium modulates ROMK channel-mediated potassium secretion. Yang L, etal., J Am Soc Nephrol. 2010 Dec;21(12):2109-16. doi: 10.1681/ASN.2010060617. Epub 2010 Oct 28.
25. Primary structure and functional properties of an epithelial K channel. Zhou H, etal., Am J Physiol. 1994 Mar;266(3 Pt 1):C809-24. doi: 10.1152/ajpcell.1994.266.3.C809.
26. Heterozygous disruption of renal outer medullary potassium channel in rats is associated with reduced blood pressure. Zhou X, etal., Hypertension. 2013 Aug;62(2):288-94. doi: 10.1161/HYPERTENSIONAHA.111.01051. Epub 2013 Jun 10.
Additional References at PubMed
PMID:11927600   PMID:12086641   PMID:12122007   PMID:12130653   PMID:12911542   PMID:12952855   PMID:14623317   PMID:14967839   PMID:15075184   PMID:15644319   PMID:15653740   PMID:15767585  
PMID:15775962   PMID:16118216   PMID:16428287   PMID:17003571   PMID:18184875   PMID:18211905   PMID:18391953   PMID:18799551   PMID:19170254   PMID:19202345   PMID:19221509   PMID:19349416  
PMID:19710010   PMID:20458182   PMID:22357918   PMID:23678039   PMID:23874410   PMID:24980796   PMID:28228405   PMID:28252570   PMID:28630040  


Genomics

Comparative Map Data
Kcnj1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8839,014,822 - 39,066,716 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl839,037,992 - 39,066,715 (+)EnsemblGRCr8
mRatBN7.2830,779,883 - 30,808,607 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl830,753,617 - 30,813,796 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx834,852,146 - 34,880,732 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0833,146,554 - 33,175,142 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0831,009,408 - 31,038,027 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0833,490,280 - 33,519,127 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl833,514,042 - 33,518,165 (+)Ensemblrn6Rnor6.0
Rnor_5.0833,453,597 - 33,454,750 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4832,158,243 - 32,162,370 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera832,231,456 - 32,260,138 (+)NCBICelera
RGSC_v3.1832,167,008 - 32,171,135 (+)NCBI
Cytogenetic Map8q21NCBI
KCNJ1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3811128,838,020 - 128,867,296 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl11128,836,315 - 128,874,671 (-)Ensemblhg38GRCh38
GRCh3711128,707,915 - 128,737,191 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3611128,213,125 - 128,242,478 (-)NCBIBuild 36Build 36hg18NCBI36
Build 3411128,213,124 - 128,242,478NCBI
Celera11125,874,052 - 125,903,407 (-)NCBICelera
Cytogenetic Map11q24.3NCBI
HuRef11124,655,619 - 124,684,981 (-)NCBIHuRef
CHM1_111128,593,943 - 128,623,302 (-)NCBICHM1_1
T2T-CHM13v2.011128,870,511 - 128,899,787 (-)NCBIT2T-CHM13v2.0
Kcnj1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39932,283,714 - 32,310,493 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl932,283,789 - 32,310,493 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38932,372,418 - 32,399,197 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl932,372,493 - 32,399,197 (+)Ensemblmm10GRCm38
MGSCv37932,180,003 - 32,206,782 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36932,143,550 - 32,148,762 (+)NCBIMGSCv36mm8
Celera929,635,143 - 29,662,007 (+)NCBICelera
Cytogenetic Map9A4NCBI
cM Map917.69NCBI
Kcnj1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541229,801,022 - 29,829,674 (-)Ensembl
ChiLan1.0NW_00495541229,801,022 - 29,832,153 (-)NCBIChiLan1.0ChiLan1.0
KCNJ1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v29129,520,412 - 129,522,718 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan111130,628,039 - 130,630,232 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v011123,649,466 - 123,680,149 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.111127,553,327 - 127,582,738 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl11127,553,327 - 127,557,860 (-)EnsemblpanPan2panpan1.1
KCNJ1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.155,783,242 - 5,813,961 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl55,809,118 - 5,812,794 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha55,843,322 - 5,875,020 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.055,743,108 - 5,773,951 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
UMICH_Zoey_3.155,802,733 - 5,834,432 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.055,780,635 - 5,811,375 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.055,814,725 - 5,846,437 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Kcnj1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947111,024,514 - 111,054,032 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365723,421,557 - 3,425,276 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365723,396,329 - 3,425,848 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
KCNJ1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl955,780,257 - 55,781,375 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1955,779,020 - 55,812,761 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2961,870,166 - 61,903,920 (-)NCBISscrofa10.2Sscrofa10.2susScr3
KCNJ1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11119,971,282 - 120,040,752 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1119,969,370 - 119,986,411 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_0236660436,047,076 - 6,118,524 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Kcnj1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248123,160,693 - 3,193,595 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248123,160,684 - 3,192,323 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Kcnj1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1828,063,100 - 28,093,524 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Kcnj1
799 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:511
Count of miRNA genes:219
Interacting mature miRNAs:259
Transcripts:ENSRNOT00000011698, ENSRNOT00000042493, ENSRNOT00000060543
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1357398Slep3Serum leptin concentration QTL 33.43blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)81799410550763951Rat
1358896Bp262Blood pressure QTL 2622.89arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)835464071107982864Rat
2317030Wbc5White blood cell count QTL 53.210.005leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)81699464261994642Rat
2302278Gluco36Glucose level QTL 364.2blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)83776085958991895Rat
12880044Am9Aortic mass QTL 90.007aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)81038254055382540Rat
631648Stl5Serum triglyceride level QTL 540.0003blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)83546407171842899Rat
724514Uae15Urinary albumin excretion QTL 152.9urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)83776085961459705Rat
2317032Ginf2Gastrointestinal inflammation QTL 23.210.005liver integrity trait (VT:0010547)liver granuloma severity score (CMO:0002157)81296416557964165Rat
2301416Bp315Blood pressure QTL 3150.008arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)81595227960952279Rat
631842Inf1Infertility severity QTL 14.10.001seminal gland mass (VT:0010524)seminal vesicle wet weight (CMO:0001603)83154366176543661Rat
2317036Livw3Liver weight QTL 32.430.01liver mass (VT:0003402)liver weight to body weight ratio (CMO:0000633)81296416557964165Rat
1358907Cm40Cardiac mass QTL 401.89heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)835464071107982864Rat
1598824Memor4Memory QTL 42.5exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)81799386262252873Rat
12880023Bw184Body weight QTL 1840.001body mass (VT:0001259)body weight (CMO:0000012)81038254055382540Rat
12880028Cm103Cardiac mass QTL 1030.02heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)81038254055382540Rat
2317051Aia18Adjuvant induced arthritis QTL 182.42joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)81699464261994642Rat
1358892Kidm26Kidney mass QTL 263.69kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)835464071107982864Rat
1359021Bp271Blood pressure QTL 2711.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)83412590255607752Rat
2317048Ginf1Gastrointestinal inflammation QTL 13.520.005cecum mucosa thickness (VT:0010234)enterocolitis severity score (CMO:0002138)81296416557964165Rat
2302367Slep5Serum leptin concentration QTL 53.43blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)81799410550763951Rat
12880025Cm102Cardiac mass QTL 1020.044heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)81038254055382540Rat

Markers in Region
BE100526  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2830,723,571 - 30,723,725 (+)MAPPERmRatBN7.2
Rnor_6.0833,434,142 - 33,434,295NCBIRnor6.0
Rnor_5.0833,451,757 - 33,451,910UniSTSRnor5.0
RGSC_v3.4832,077,188 - 32,077,341UniSTSRGSC3.4
Celera832,176,780 - 32,176,933UniSTS
RH 3.4 Map8244.6UniSTS
Cytogenetic Map8q21UniSTS


Genetic Models
This gene Kcnj1 is modified in the following models/strains:
SS-Kcnj1em1Kasu-/-     SS-Kcnj1em1Kasu+/-    


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
8 9 48 83 62 64 37 81 37 1 283 150 9 64 80 49 27 10 10

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001309297 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001309298 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001309299 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001309301 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_017023 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008766044 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008766047 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017595458 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063264896 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063264897 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063264898 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063264899 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC127149 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF081365 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF081366 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF081367 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF081368 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH474007 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000008 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L29403 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  S69385 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  S78155 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X72341 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000081525   ⟹   ENSRNOP00000072157
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl839,061,641 - 39,066,715 (+)Ensembl
mRatBN7.2 Ensembl830,803,533 - 30,808,607 (+)Ensembl
Rnor_6.0 Ensembl833,514,042 - 33,518,165 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000081614   ⟹   ENSRNOP00000070813
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl839,061,641 - 39,066,715 (+)Ensembl
mRatBN7.2 Ensembl830,803,533 - 30,808,607 (+)Ensembl
Rnor_6.0 Ensembl833,514,042 - 33,518,165 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000096412   ⟹   ENSRNOP00000087977
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl830,779,857 - 30,813,796 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000099372   ⟹   ENSRNOP00000078843
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl839,037,992 - 39,066,715 (+)Ensembl
mRatBN7.2 Ensembl830,753,617 - 30,808,616 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000104685   ⟹   ENSRNOP00000091473
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl830,779,857 - 30,813,796 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000107151   ⟹   ENSRNOP00000092814
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl830,779,857 - 30,813,796 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000108956   ⟹   ENSRNOP00000093336
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl830,803,031 - 30,813,796 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000110096   ⟹   ENSRNOP00000077878
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl839,037,992 - 39,066,715 (+)Ensembl
mRatBN7.2 Ensembl830,779,883 - 30,808,616 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000112136   ⟹   ENSRNOP00000082481
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl830,796,998 - 30,809,131 (+)Ensembl
RefSeq Acc Id: NM_001309297   ⟹   NP_001296226
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8839,037,992 - 39,066,715 (+)NCBI
mRatBN7.2830,779,883 - 30,808,607 (+)NCBI
Rnor_6.0833,490,306 - 33,519,116 (+)NCBI
Celera832,231,456 - 32,260,138 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001309298   ⟹   NP_001296227
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8839,061,641 - 39,066,715 (+)NCBI
mRatBN7.2830,803,533 - 30,808,607 (+)NCBI
Rnor_6.0833,514,042 - 33,519,116 (+)NCBI
Celera832,255,061 - 32,260,138 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001309299   ⟹   NP_001296228
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8839,037,992 - 39,066,715 (+)NCBI
mRatBN7.2830,779,883 - 30,808,607 (+)NCBI
Rnor_6.0833,490,306 - 33,519,116 (+)NCBI
Celera832,231,456 - 32,260,138 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001309301   ⟹   NP_001296230
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8839,061,641 - 39,066,715 (+)NCBI
mRatBN7.2830,803,533 - 30,808,607 (+)NCBI
Rnor_6.0833,514,042 - 33,519,116 (+)NCBI
Celera832,255,061 - 32,260,138 (+)NCBI
Sequence:
RefSeq Acc Id: NM_017023   ⟹   NP_058719
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8839,061,641 - 39,066,715 (+)NCBI
mRatBN7.2830,803,533 - 30,808,607 (+)NCBI
Rnor_6.0833,514,042 - 33,519,116 (+)NCBI
Rnor_5.0833,453,597 - 33,454,750 (+)NCBI
RGSC_v3.4832,158,243 - 32,162,370 (+)RGD
Celera832,255,061 - 32,260,138 (+)NCBI
Sequence:
RefSeq Acc Id: XM_063264896   ⟹   XP_063120966
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8839,014,822 - 39,066,716 (+)NCBI
RefSeq Acc Id: XM_063264897   ⟹   XP_063120967
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8839,037,983 - 39,066,716 (+)NCBI
RefSeq Acc Id: XM_063264898   ⟹   XP_063120968
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8839,037,980 - 39,066,716 (+)NCBI
RefSeq Acc Id: XM_063264899   ⟹   XP_063120969
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8839,014,822 - 39,066,716 (+)NCBI
RefSeq Acc Id: NP_058719   ⟸   NM_017023
- Peptide Label: isoform 1
- UniProtKB: Q9QUR5 (UniProtKB/Swiss-Prot),   P35560 (UniProtKB/Swiss-Prot),   O88640 (UniProtKB/Swiss-Prot),   O88639 (UniProtKB/Swiss-Prot),   A0A0G2JYW2 (UniProtKB/TrEMBL),   A6JYH9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001296228   ⟸   NM_001309299
- Peptide Label: isoform 3
- UniProtKB: A0A0G2K298 (UniProtKB/TrEMBL),   A6JYI4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001296226   ⟸   NM_001309297
- Peptide Label: isoform 2
- UniProtKB: Q9QUR5 (UniProtKB/Swiss-Prot),   P35560 (UniProtKB/Swiss-Prot),   O88640 (UniProtKB/Swiss-Prot),   O88639 (UniProtKB/Swiss-Prot),   A0A8I6AW52 (UniProtKB/TrEMBL),   A6JYI0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001296227   ⟸   NM_001309298
- Peptide Label: isoform 3
- UniProtKB: A0A0G2K298 (UniProtKB/TrEMBL),   A6JYI4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001296230   ⟸   NM_001309301
- Peptide Label: isoform 3
- UniProtKB: A0A0G2K298 (UniProtKB/TrEMBL),   A6JYI4 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000070813   ⟸   ENSRNOT00000081614
Ensembl Acc Id: ENSRNOP00000072157   ⟸   ENSRNOT00000081525
Ensembl Acc Id: ENSRNOP00000077878   ⟸   ENSRNOT00000110096
Ensembl Acc Id: ENSRNOP00000078843   ⟸   ENSRNOT00000099372
Ensembl Acc Id: ENSRNOP00000092814   ⟸   ENSRNOT00000107151
Ensembl Acc Id: ENSRNOP00000093336   ⟸   ENSRNOT00000108956
Ensembl Acc Id: ENSRNOP00000087977   ⟸   ENSRNOT00000096412
Ensembl Acc Id: ENSRNOP00000082481   ⟸   ENSRNOT00000112136
Ensembl Acc Id: ENSRNOP00000091473   ⟸   ENSRNOT00000104685
RefSeq Acc Id: XP_063120966   ⟸   XM_063264896
- Peptide Label: isoform X1
- UniProtKB: A0A8I5ZLP0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063120969   ⟸   XM_063264899
- Peptide Label: isoform X3
RefSeq Acc Id: XP_063120968   ⟸   XM_063264898
- Peptide Label: isoform X2
- UniProtKB: Q9QUR5 (UniProtKB/Swiss-Prot),   P35560 (UniProtKB/Swiss-Prot),   O88640 (UniProtKB/Swiss-Prot),   O88639 (UniProtKB/Swiss-Prot),   A0A8I5ZJL6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063120967   ⟸   XM_063264897
- Peptide Label: isoform X2
- UniProtKB: Q9QUR5 (UniProtKB/Swiss-Prot),   P35560 (UniProtKB/Swiss-Prot),   O88640 (UniProtKB/Swiss-Prot),   O88639 (UniProtKB/Swiss-Prot),   A0A8I5ZJL6 (UniProtKB/TrEMBL)
Protein Domains
Inward rectifier potassium channel C-terminal   Potassium channel inwardly rectifying transmembrane

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P35560-F1-model_v2 AlphaFold P35560 1-391 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13695837
Promoter ID:EPDNEW_R6355
Type:single initiation site
Name:Kcnj1_1
Description:potassium voltage-gated channel subfamily J member 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0833,514,016 - 33,514,076EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2957 AgrOrtholog
BioCyc Gene G2FUF-31235 BioCyc
Ensembl Genes ENSRNOG00000059005 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000081525 ENTREZGENE
  ENSRNOT00000081614 ENTREZGENE
  ENSRNOT00000099372 ENTREZGENE
  ENSRNOT00000110096 ENTREZGENE
Gene3D-CATH 1.10.287.70 UniProtKB/Swiss-Prot
  2.60.40.1400 UniProtKB/Swiss-Prot
InterPro Ig_E-set UniProtKB/Swiss-Prot
  IRK_C UniProtKB/Swiss-Prot
  K_chnl_inward-rec_Kir UniProtKB/Swiss-Prot
  K_chnl_inward-rec_Kir1.1 UniProtKB/Swiss-Prot
  K_chnl_inward-rec_Kir_cyto UniProtKB/Swiss-Prot
  Kir_TM UniProtKB/Swiss-Prot
NCBI Gene 24521 ENTREZGENE
PANTHER PTHR11767 UniProtKB/Swiss-Prot
  PTHR11767:SF6 UniProtKB/Swiss-Prot
Pfam IRK UniProtKB/Swiss-Prot
  IRK_C UniProtKB/Swiss-Prot
PhenoGen Kcnj1 PhenoGen
PIRSF GIRK_kir UniProtKB/Swiss-Prot
PRINTS KIR11CHANNEL UniProtKB/Swiss-Prot
  KIRCHANNEL UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000059005 RatGTEx
Superfamily-SCOP SSF81296 UniProtKB/Swiss-Prot
  Voltage-gated potassium channels UniProtKB/Swiss-Prot
UniProt A0A0G2JYW2 ENTREZGENE, UniProtKB/TrEMBL
  A0A0G2K298 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5ZJL6 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5ZLP0 ENTREZGENE
  A0A8I6AW52 ENTREZGENE
  A6JYH9 ENTREZGENE, UniProtKB/TrEMBL
  A6JYI0 ENTREZGENE, UniProtKB/TrEMBL
  A6JYI4 ENTREZGENE, UniProtKB/TrEMBL
  KCNJ1_RAT UniProtKB/Swiss-Prot
  O88639 ENTREZGENE
  O88640 ENTREZGENE
  P35560 ENTREZGENE
  Q9QUR5 ENTREZGENE
UniProt Secondary O88639 UniProtKB/Swiss-Prot
  O88640 UniProtKB/Swiss-Prot
  Q9QUR5 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2018-09-06 Kcnj1  potassium voltage-gated channel subfamily J member 1  Kcnj1_v3  potassium voltage-gated channel subfamily J member 1, variant 3  Data merged from RGD:728315 737654 PROVISIONAL
2018-09-06 Kcnj1  potassium voltage-gated channel subfamily J member 1  Kcnj1_v1  potassium voltage-gated channel subfamily J member 1, variant 1  Data merged from RGD:728323 737654 PROVISIONAL
2016-02-11 Kcnj1  potassium voltage-gated channel subfamily J member 1  Kcnj1  potassium channel, inwardly rectifying subfamily J, member 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2015-01-26 Kcnj1  potassium channel, inwardly rectifying subfamily J, member 1  Kcnj1  potassium inwardly-rectifying channel, subfamily J, member 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-12-14 Kcnj1_v3  potassium inwardly-rectifying channel, subfamily J, member 1, variant 3    potassium inwardly-rectifying channel, subfamily J, variant 3  Name updated 1299863 APPROVED
2004-12-14 Kcnj1_v1  potassium inwardly-rectifying channel, subfamily J, member 1, variant 1    potassium inwardly-rectifying channel, subfamily J, variant 1  Name updated 1299863 APPROVED
2001-10-23 Kcnj1  Potassium inwardly-rectifying channel, subfamily J, member 1      Name withdrawn 68913 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_domains contains two potential membrane-spanning helices and a proposed ATP-binding domain 729173
gene_expression ROMK1 is expressed only in the cortical collecting duct of kidney 70578
gene_expression ROMK3 is expressed only in the thick ascending limb (TAL)of the loop of Henle cells 70578
gene_function ROMK1 associates with Cftr and Abcc9 to form K+ ATP channels 70578
gene_function IRA triplet in the NH2-terminal extensions of ROMK3 may play a role in subunit assembly of the renal secretary KATP channel 70578
gene_function ROMK3 associates with Cftr and Abcc9 to form K-ATP channels 70578
gene_process ROMK1 does not form glibenclamide-sensitive K+ channels when co-expressed with Abcc9, but ROMK2 does 70578
gene_process ROMK1 mediates K(+) secretion into urine 70578
gene_process ROMK3 does not form glibenclamide-sensitive K+ channels when co-expressed with Abcc9, but ROMK2 does 70578
gene_process ROMK3 mediates K(+) secretion into urine 70578
gene_protein amino acids 13-19 ROMK1 are identical to 20-26 in ROMK3 70578
gene_protein ROMK1 shares the core polypeptide of ROMK2 but with distinct NH2-terminal extension of 19 amino acids 70578
gene_protein amino-terminal extension of ROMK1 plays a role in inhibiting subunit assembly with Abcc9 70578
gene_protein ROMK3 amino acids 20-26 in the NH2-terminal extensions are identical to amino acids 13-19 in ROMK1 70578
gene_protein ROMK3 shares the core polypeptide of ROMK2 but with distinct NH2-terminal extensions of 26 amino acids 70578