Kcnb1 (potassium voltage-gated channel subfamily B member 1) - Rat Genome Database

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Gene: Kcnb1 (potassium voltage-gated channel subfamily B member 1) Rattus norvegicus
Analyze
Symbol: Kcnb1
Name: potassium voltage-gated channel subfamily B member 1
RGD ID: 2954
Description: Enables several functions, including protein heterodimerization activity; transmembrane transporter binding activity; and voltage-gated potassium channel activity. Involved in several processes, including clustering of voltage-gated potassium channels; positive regulation of secretion by cell; and potassium ion export across plasma membrane. Acts upstream of or within potassium ion transport. Located in several cellular components, including dendrite; lateral plasma membrane; and neuronal cell body membrane. Part of voltage-gated potassium channel complex. Is active in cholinergic synapse and postsynaptic specialization membrane. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 26 and epilepsy. Orthologous to human KCNB1 (potassium voltage-gated channel subfamily B member 1); PARTICIPATES IN insulin secretion pathway; INTERACTS WITH (5Z,8Z,11Z,13E)-15-HETE; 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: delayed rectifier potassium channel 1; DRK1; DRK1PC; Kcr1-1; Kv2.1; potassium channel Kv2.1; potassium channel, voltage gated Shab-related subfamily B, member 1; potassium voltage gated channel, Shab-related subfamily, member 1; Shab; voltage-gated potassium channel subunit Kv2.1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Candidate Gene For: Niddm39 Eau4
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83176,239,285 - 176,332,408 (-)NCBIGRCr8
mRatBN7.23155,820,255 - 155,913,383 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3155,822,963 - 155,916,194 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3159,621,853 - 159,714,946 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03168,120,826 - 168,213,919 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03165,862,536 - 165,955,629 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03163,850,785 - 163,935,610 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3163,850,785 - 163,935,617 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03170,010,756 - 170,094,507 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43158,250,001 - 158,345,927 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.13158,156,036 - 158,248,459 (-)NCBI
Celera3154,408,682 - 154,493,576 (-)NCBICelera
RH 3.4 Map31476.0RGD
Cytogenetic Map3q42NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(5Z,8Z,11Z,13E)-15-HETE  (EXP)
1,2-dimethylhydrazine  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
6-propyl-2-thiouracil  (EXP)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
amiodarone  (ISO)
amitrole  (EXP)
amphotericin B  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (EXP)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
atrazine  (ISO)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
cantharidin  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chlorpyrifos  (ISO)
cisplatin  (ISO)
cocaine  (EXP,ISO)
crocidolite asbestos  (ISO)
Cuprizon  (EXP)
cyclosporin A  (ISO)
dexamethasone  (EXP,ISO)
diarsenic trioxide  (ISO)
dibenz[a,h]anthracene  (ISO)
dichlorine  (EXP)
dioxygen  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (ISO)
ethanol  (ISO)
ferrostatin-1  (ISO)
fipronil  (EXP)
flavonoids  (EXP)
formaldehyde  (ISO)
furan  (EXP)
genistein  (EXP)
gentamycin  (EXP)
indometacin  (ISO)
isoprenaline  (ISO)
L-ascorbic acid  (ISO)
lead diacetate  (ISO)
Licochalcone B  (ISO)
medroxyprogesterone acetate  (ISO)
methamphetamine  (EXP,ISO)
methimazole  (EXP)
methoxychlor  (EXP)
methylmercury chloride  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
monocrotaline  (EXP)
nickel atom  (ISO)
nitrofen  (EXP)
ozone  (EXP,ISO)
paracetamol  (EXP,ISO)
phenylmercury acetate  (ISO)
pioglitazone  (ISO)
pirinixic acid  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP,ISO)
rotenone  (EXP)
SB 203580  (EXP)
SB 431542  (ISO)
scopolamine  (EXP)
silicon dioxide  (ISO)
sodium arsenate  (ISO)
sulfadimethoxine  (EXP)
trichostatin A  (ISO)
triptonide  (ISO)
valproic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Developmental and epilepsy spectrum of KCNB1 encephalopathy with long-term outcome. Bar C, etal., Epilepsia. 2020 Nov;61(11):2461-2473. doi: 10.1111/epi.16679. Epub 2020 Sep 21.
2. Neurodevelopmental Disorders Caused by De Novo Variants in KCNB1 Genotypes and Phenotypes. de Kovel CGF, etal., JAMA Neurol. 2017 Oct 1;74(10):1228-1236. doi: 10.1001/jamaneurol.2017.1714.
3. Kv2.1 cell surface clusters are insertion platforms for ion channel delivery to the plasma membrane. Deutsch E, etal., Mol Biol Cell. 2012 Aug;23(15):2917-29. doi: 10.1091/mbc.E12-01-0047. Epub 2012 May 30.
4. Distinct spatial and temporal expression patterns of K+ channel mRNAs from different subfamilies. Drewe JA, etal., J Neurosci 1992 Feb;12(2):538-48.
5. Novel tarantula toxins for subtypes of voltage-dependent potassium channels in the Kv2 and Kv4 subfamilies. Escoubas P, etal., Mol Pharmacol. 2002 Jul;62(1):48-57. doi: 10.1124/mol.62.1.48.
6. Non-conducting function of the Kv2.1 channel enables it to recruit vesicles for release in neuroendocrine and nerve cells. Feinshreiber L, etal., J Cell Sci. 2010 Jun 1;123(Pt 11):1940-7. doi: 10.1242/jcs.063719.
7. Reduced sensory synaptic excitation impairs motor neuron function via Kv2.1 in spinal muscular atrophy. Fletcher EV, etal., Nat Neurosci. 2017 Jul;20(7):905-916. doi: 10.1038/nn.4561. Epub 2017 May 15.
8. A novel potassium channel with delayed rectifier properties isolated from rat brain by expression cloning. Frech GC, etal., Nature 1989 Aug 24;340(6235):642-5.
9. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
10. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
11. Epilepsy and neurobehavioral abnormalities in mice with a dominant-negative KCNB1 pathogenic variant. Hawkins NA, etal., Neurobiol Dis. 2021 Jan;147:105141. doi: 10.1016/j.nbd.2020.105141. Epub 2020 Oct 22.
12. Modulation of Kv2.1 channel gating and TEA sensitivity by distinct domains of SNAP-25. He Y, etal., Biochem J. 2006 Jun 1;396(2):363-9.
13. Contrasting immunohistochemical localizations in rat brain of two novel K+ channels of the Shab subfamily. Hwang PM, etal., J Neurosci. 1993 Apr;13(4):1569-76.
14. The Roles of N- and C-terminal determinants in the activation of the Kv2.1 potassium channel. Ju M, etal., J Biol Chem. 2003 Apr 11;278(15):12769-78. doi: 10.1074/jbc.M212973200. Epub 2003 Jan 29.
15. KCNE1 and KCNE2 provide a checkpoint governing voltage-gated potassium channel a-subunit composition. Kanda VA, etal., Biophys J. 2011 Sep 21;101(6):1364-75. doi: 10.1016/j.bpj.2011.08.014. Epub 2011 Sep 20.
16. Formation of heteromeric Kv2 channels in mammalian brain neurons. Kihira Y, etal., J Biol Chem. 2010 May 14;285(20):15048-55. doi: 10.1074/jbc.M109.074260. Epub 2010 Mar 4.
17. Inactivation of Kv2.1 potassium channels. Klemic KG, etal., Biophys J. 1998 Apr;74(4):1779-89.
18. Modulation of potassium channel gating by coexpression of Kv2.1 with regulatory Kv5.1 or Kv6.1 alpha-subunits. Kramer JW, etal., Am J Physiol. 1998 Jun;274(6):C1501-10. doi: 10.1152/ajpcell.1998.274.6.C1501.
19. High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
20. Internal Na+ and Mg2+ blockade of DRK1 (Kv2.1) potassium channels expressed in Xenopus oocytes. Inward rectification of a delayed rectifier. Lopatin AN and Nichols CG, J Gen Physiol. 1994 Feb;103(2):203-16.
21. Contributions of Kv1.2, Kv1.5 and Kv2.1 subunits to the native delayed rectifier K(+) current in rat mesenteric artery smooth muscle cells. Lu Y, etal., Life Sci. 2002 Aug 9;71(12):1465-73.
22. Rearrangements in the relative orientation of cytoplasmic domains induced by a membrane-anchored protein mediate modulations in Kv channel gating. Lvov A, etal., J Biol Chem. 2009 Oct 9;284(41):28276-91. doi: 10.1074/jbc.M109.028761. Epub 2009 Aug 18.
23. Voltage-dependent K(+) channels in pancreatic beta cells: role, regulation and potential as therapeutic targets. MacDonald PE and Wheeler MB, Diabetologia. 2003 Aug;46(8):1046-62. Epub 2003 Jun 27.
24. Regulation of the Kv2.1 potassium channel by MinK and MiRP1. McCrossan ZA, etal., J Membr Biol. 2009 Mar;228(1):1-14. doi: 10.1007/s00232-009-9154-8. Epub 2009 Feb 14.
25. MinK-related peptide 2 modulates Kv2.1 and Kv3.1 potassium channels in mammalian brain. McCrossan ZA, etal., J Neurosci. 2003 Sep 3;23(22):8077-91.
26. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
27. Focal aggregation of voltage-gated, Kv2.1 subunit-containing, potassium channels at synaptic sites in rat spinal motoneurones. Muennich EA and Fyffe RE, J Physiol. 2004 Feb 1;554(Pt 3):673-85. Epub 2003 Nov 7.
28. Phosphorylation of the Kv2.1 K+ channel alters voltage-dependent activation. Murakoshi H, etal., Mol Pharmacol. 1997 Nov;52(5):821-8. doi: 10.1124/mol.52.5.821.
29. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
30. Kv2.1/Kv9.3, a novel ATP-dependent delayed-rectifier K+ channel in oxygen-sensitive pulmonary artery myocytes. Patel AJ, etal., EMBO J 1997 Nov 17;16(22):6615-25.
31. Kv2.1 and electrically silent Kv6.1 potassium channel subunits combine and express a novel current. Post MA, etal., FEBS Lett. 1996 Dec 9;399(1-2):177-82.
32. GOA pipeline RGD automated data pipeline
33. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
34. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
35. Redistribution of Kv2.1 ion channels on spinal motoneurons following peripheral nerve injury. Romer SH, etal., Brain Res. 2014 Feb 14;1547:1-15. doi: 10.1016/j.brainres.2013.12.012. Epub 2013 Dec 16.
36. New modulatory alpha subunits for mammalian Shab K+ channels. Salinas M, etal., J Biol Chem 1997 Sep 26;272(39):24371-9.
37. The Kv2.1 K+ channel targets to the axon initial segment of hippocampal and cortical neurons in culture and in situ. Sarmiere PD, etal., BMC Neurosci. 2008 Nov 13;9:112. doi: 10.1186/1471-2202-9-112.
38. Identification of a cytoplasmic domain important in the polarized expression and clustering of the Kv2.1 K+ channel. Scannevin RH, etal., J Cell Biol. 1996 Dec;135(6 Pt 1):1619-32. doi: 10.1083/jcb.135.6.1619.
39. Properties of Kv2.1 K+ channels expressed in transfected mammalian cells. Shi G, etal., J Biol Chem. 1994 Sep 16;269(37):23204-11.
40. K+ channel facilitation of exocytosis by dynamic interaction with syntaxin. Singer-Lahat D, etal., J Neurosci. 2007 Feb 14;27(7):1651-8.
41. Direct interaction of endogenous Kv channels with syntaxin enhances exocytosis by neuroendocrine cells. Singer-Lahat D, etal., PLoS One. 2008 Jan 2;3(1):e1381. doi: 10.1371/journal.pone.0001381.
42. Deletion of the Kv2.1 delayed rectifier potassium channel leads to neuronal and behavioral hyperexcitability. Speca DJ, etal., Genes Brain Behav. 2014 Apr;13(4):394-408. doi: 10.1111/gbb.12120. Epub 2014 Mar 7.
43. An inhibitor of the Kv2.1 potassium channel isolated from the venom of a Chilean tarantula. Swartz KJ and MacKinnon R, Neuron. 1995 Oct;15(4):941-9. doi: 10.1016/0896-6273(95)90184-1.
44. Patterns of internal and external tetraethylammonium block in four homologous K+ channels. Taglialatela M, etal., Mol Pharmacol. 1991 Aug;40(2):299-307.
45. Alteration and restoration of K+ channel function by deletions at the N- and C-termini. VanDongen AM, etal., Neuron. 1990 Oct;5(4):433-43. doi: 10.1016/0896-6273(90)90082-q.
46. Modification of Kv2.1 K+ currents by the silent Kv10 subunits. Vega-Saenz de Miera EC Brain Res Mol Brain Res. 2004 Apr 7;123(1-2):91-103.
47. Cloning and expression of a novel K+ channel regulatory protein, KChAP. Wible BA, etal., J Biol Chem 1998 May 8;273(19):11745-51.
48. The Kv2.1 channels mediate neuronal apoptosis induced by excitotoxicity. Yao H, etal., J Neurochem. 2009 Feb;108(4):909-19. doi: 10.1111/j.1471-4159.2008.05834.x. Epub 2008 Dec 10.
Additional References at PubMed
PMID:12562993   PMID:12615930   PMID:12744302   PMID:12832499   PMID:14550259   PMID:15073181   PMID:15217912   PMID:15322114   PMID:15353504   PMID:16008572   PMID:16319318   PMID:16407566  
PMID:16917065   PMID:16988031   PMID:17379638   PMID:17767909   PMID:18065659   PMID:18174882   PMID:18270591   PMID:18463252   PMID:18542995   PMID:18716211   PMID:18982871   PMID:19074135  
PMID:19223394   PMID:19276663   PMID:19472219   PMID:19500583   PMID:19616547   PMID:20092568   PMID:20403337   PMID:20680544   PMID:20709754   PMID:20876197   PMID:21365420   PMID:21412780  
PMID:21451062   PMID:21518833   PMID:21562308   PMID:21806933   PMID:22052159   PMID:22056818   PMID:22118516   PMID:22411134   PMID:22554782   PMID:22969075   PMID:23223293   PMID:23918396  
PMID:24086760   PMID:24252178   PMID:25256718   PMID:26393286   PMID:28483976   PMID:28768770   PMID:28867730   PMID:29042434   PMID:29549124   PMID:29941597   PMID:30190339   PMID:30824538  
PMID:31145471   PMID:31308225   PMID:33060203   PMID:33333928   PMID:33854181   PMID:37566068  


Genomics

Comparative Map Data
Kcnb1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83176,239,285 - 176,332,408 (-)NCBIGRCr8
mRatBN7.23155,820,255 - 155,913,383 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3155,822,963 - 155,916,194 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3159,621,853 - 159,714,946 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03168,120,826 - 168,213,919 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03165,862,536 - 165,955,629 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03163,850,785 - 163,935,610 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3163,850,785 - 163,935,617 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03170,010,756 - 170,094,507 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43158,250,001 - 158,345,927 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.13158,156,036 - 158,248,459 (-)NCBI
Celera3154,408,682 - 154,493,576 (-)NCBICelera
RH 3.4 Map31476.0RGD
Cytogenetic Map3q42NCBI
KCNB1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382049,363,877 - 49,483,362 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2049,293,394 - 49,484,297 (-)EnsemblGRCh38hg38GRCh38
GRCh372047,980,414 - 48,099,205 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362047,421,912 - 47,532,588 (-)NCBINCBI36Build 36hg18NCBI36
Build 342047,421,911 - 47,532,588NCBI
Celera2044,693,122 - 44,803,814 (-)NCBICelera
Cytogenetic Map20q13.13NCBI
HuRef2044,737,067 - 44,847,754 (-)NCBIHuRef
CHM1_12047,892,894 - 48,003,606 (-)NCBICHM1_1
T2T-CHM13v2.02051,133,489 - 51,253,649 (-)NCBIT2T-CHM13v2.0
Kcnb1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392166,937,889 - 167,032,088 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2166,937,889 - 167,032,075 (-)EnsemblGRCm39 Ensembl
GRCm382167,095,969 - 167,190,072 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2167,095,969 - 167,190,155 (-)EnsemblGRCm38mm10GRCm38
MGSCv372166,928,878 - 167,014,299 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv362166,794,583 - 166,880,004 (-)NCBIMGSCv36mm8
Celera2173,043,474 - 173,128,977 (-)NCBICelera
Cytogenetic Map2H3NCBI
cM Map287.22NCBI
Kcnb1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554458,680,965 - 8,774,110 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554458,680,979 - 8,779,662 (+)NCBIChiLan1.0ChiLan1.0
KCNB1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22155,039,862 - 55,225,053 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12055,032,968 - 55,218,159 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02045,636,371 - 45,821,536 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12046,761,428 - 46,885,521 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2046,776,274 - 46,885,521 (-)Ensemblpanpan1.1panPan2
KCNB1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12436,016,800 - 36,118,873 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2436,025,472 - 36,117,934 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2435,259,329 - 35,359,756 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02436,721,821 - 36,822,593 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2436,729,609 - 36,823,404 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12435,962,506 - 36,063,208 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02436,096,677 - 36,197,268 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02436,638,300 - 36,739,394 (-)NCBIUU_Cfam_GSD_1.0
Kcnb1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640189,373,582 - 189,447,939 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365144,827,127 - 4,900,707 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365144,827,156 - 4,902,271 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
KCNB1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1751,039,987 - 51,142,644 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11751,032,163 - 51,152,566 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21757,354,303 - 57,464,782 (-)NCBISscrofa10.2Sscrofa10.2susScr3
KCNB1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1214,510,176 - 14,623,054 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl214,510,464 - 14,619,023 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605062,995,224 - 63,111,025 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Kcnb1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247905,902,077 - 6,003,591 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247905,901,809 - 6,007,847 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Kcnb1
443 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:109
Count of miRNA genes:89
Interacting mature miRNAs:96
Transcripts:ENSRNOT00000074023
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
12879876Bw182Body weight QTL 1820.003body mass (VT:0001259)body weight (CMO:0000012)3145925360166177555Rat
2301411Bp320Blood pressure QTL 3200.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)3145925360166177555Rat
2312673Scl63Serum cholesterol level QTL 630.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)398535255168026850Rat
1300113Bp176Blood pressure QTL 1763.9arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)3145956084157309487Rat
12879872Cm97Cardiac mass QTL 970.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)3145925360166177555Rat
1598877Bp285Blood pressure QTL 2851.50.03arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3120538241165538241Rat
1578653Vnigr3Vascular neointimal growth QTL 33.1artery morphology trait (VT:0002191)artery neointimal hyperplastic lesion area (CMO:0001414)3130656562169034231Rat
12879873Cm96Cardiac mass QTL 960.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)3145925360166177555Rat
2302373Gluco39Glucose level QTL 395.01blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)398535386161695835Rat
12879874Cm98Cardiac mass QTL 980.005heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)3145925360166177555Rat
1298068Bp167Blood pressure QTL 1670.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3141074471169034231Rat
12879875Kidm64Kidney mass QTL 640.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)3145925360166177555Rat
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)331172320163586636Rat
2298477Eau4Experimental allergic uveoretinitis QTL 40.0011uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)3137398739169034231Rat
8552791Vie2Viral induced encephalitis QTL 24.1brain integrity trait (VT:0010579)encephalitis incidence/prevalence measurement (CMO:0002361)3145956084169034231Rat
1581568Rf53Renal function QTL 53urine total protein amount (VT:0000032)urine protein excretion rate to body weight ratio (CMO:0001099)356395968161299569Rat
2317883Alcrsp26Alcohol response QTL 261.80.63response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)3145526770169034231Rat
1578754Stresp16Stress response QTL 1640.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)3112681431157681431Rat
1331726Bp208Blood pressure QTL 2083.129arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)3141339013162184794Rat
1598854Memor10Memory QTL 102exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)3145956084161299569Rat
9589106Insul23Insulin level QTL 2313.860.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)3131635904169034231Rat
10755461Coatc16Coat color QTL 16coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)3122438700167438700Rat
8662816Vetf4Vascular elastic tissue fragility QTL 44renal artery integrity trait (VT:0010642)number of ruptures of the internal elastic lamina of the renal arteries (CMO:0002563)359242096157323038Rat
1559282Emca5Estrogen-induced mammary cancer QTL 53.9mammary gland integrity trait (VT:0010552)percentage of study population developing mammary tumors during a period of time (CMO:0000948)343827364169034231Rat
2303620Vencon4Ventilatory control QTL 43.9respiration trait (VT:0001943)tidal volume (CMO:0000222)3127162703168026850Rat
631841Niddm39Non-insulin dependent diabetes mellitus QTL 393.36blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)394856903159898684Rat
1576306Schws3Schwannoma susceptibility QTL 30.001nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)3118839124163839124Rat
1300159Kidm4Kidney mass QTL 43.83kidney mass (VT:0002707)right kidney wet weight to body weight ratio (CMO:0001953)3121056165157309487Rat
2312659Slep7Serum leptin concentration QTL 70.001blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)398535255168026850Rat
631673Iddm13Insulin dependent diabetes mellitus QTL 131.30.663blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)3130193298161695983Rat
1578666Vnigr1Vascular neointimal growth QTL 14.6artery morphology trait (VT:0002191)artery lumen area (CMO:0001409)3149040888168026850Rat
1578656Vnigr2Vascular neointimal growth QTL 24.2artery morphology trait (VT:0002191)lesioned artery residual lumen area (CMO:0001417)3130656562169034231Rat
8552952Pigfal13Plasma insulin-like growth factor 1 level QTL 13blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)3138799500169034231Rat
12879871Am7Aortic mass QTL 70.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)3145925360166177555Rat
631541Bp81Blood pressure QTL 814arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3124122556169034231Rat
2312670Bw94Body weight QTL 940.01inguinal fat pad mass (VT:0010424)inguinal fat pad weight to body weight ratio (CMO:0001253)398535255168026850Rat

Markers in Region
Kcnb1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23155,828,898 - 155,829,009 (+)MAPPERmRatBN7.2
Rnor_6.03163,851,935 - 163,852,045NCBIRnor6.0
Rnor_5.03170,011,906 - 170,012,016UniSTSRnor5.0
Celera3154,409,832 - 154,409,942UniSTS
Cytogenetic Map3q42UniSTS
RH131835  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23155,827,817 - 155,827,998 (+)MAPPERmRatBN7.2
Rnor_6.03163,850,854 - 163,851,034NCBIRnor6.0
Rnor_5.03170,010,825 - 170,011,005UniSTSRnor5.0
RGSC_v3.43158,250,070 - 158,250,252UniSTSRGSC3.4
Celera3154,408,751 - 154,408,931UniSTS
RH 3.4 Map31473.5UniSTS
Cytogenetic Map3q42UniSTS
RH94649  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23155,827,783 - 155,827,958 (+)MAPPERmRatBN7.2
Rnor_6.03163,850,820 - 163,850,994NCBIRnor6.0
Rnor_5.03170,010,791 - 170,010,965UniSTSRnor5.0
RGSC_v3.43158,250,036 - 158,250,211UniSTSRGSC3.4
Celera3154,408,717 - 154,408,891UniSTS
RH 3.4 Map31476.0UniSTS
Cytogenetic Map3q42UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 6 6 3 3 184 9 21 3
Low 21 138 92 30 24 30 31 38 66 115 110 36 21
Below cutoff 76 64 39 64 26

Sequence


Ensembl Acc Id: ENSRNOT00000074023   ⟹   ENSRNOP00000065961
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl3155,822,963 - 155,916,194 (-)Ensembl
Rnor_6.0 Ensembl3163,850,785 - 163,935,617 (-)Ensembl
RefSeq Acc Id: NM_013186   ⟹   NP_037318
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83176,239,285 - 176,332,408 (-)NCBI
mRatBN7.23155,820,255 - 155,913,383 (-)NCBI
Rnor_6.03163,850,785 - 163,935,610 (-)NCBI
Rnor_5.03170,010,756 - 170,094,507 (-)NCBI
RGSC_v3.43158,250,001 - 158,345,927 (-)RGD
Celera3154,408,682 - 154,493,576 (-)RGD
Sequence:
RefSeq Acc Id: XR_010064569
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83176,239,285 - 176,332,214 (-)NCBI
Protein Sequences
Protein RefSeqs NP_037318 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein CAA34497 (Get FASTA)   NCBI Sequence Viewer  
  EDL96420 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000065961
  ENSRNOP00000065961.3
  ENSRNOP00055005484
  ENSRNOP00060000671
  ENSRNOP00065016456
GenBank Protein P15387 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_037318   ⟸   NM_013186
- UniProtKB: P15387 (UniProtKB/Swiss-Prot),   A6JXI9 (UniProtKB/TrEMBL),   A0A0H2UI34 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000065961   ⟸   ENSRNOT00000074023
Protein Domains
BTB

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P15387-F1-model_v2 AlphaFold P15387 1-857 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2954 AgrOrtholog
BioCyc Gene G2FUF-46745 BioCyc
Ensembl Genes ENSRNOG00000046949 Ensembl, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00055004620 UniProtKB/Swiss-Prot
  ENSRNOG00060001059 UniProtKB/Swiss-Prot
  ENSRNOG00065013004 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000074023 UniProtKB/TrEMBL
  ENSRNOT00000074023.3 UniProtKB/Swiss-Prot
  ENSRNOT00055007323 UniProtKB/Swiss-Prot
  ENSRNOT00060001439 UniProtKB/Swiss-Prot
  ENSRNOT00065021296 UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.287.70 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  1.20.120.350 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro BTB/POZ_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ion_trans_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  K_chnl_volt-dep_Kv UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  K_chnl_volt-dep_Kv2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  K_chnl_volt-dep_Kv2.1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SKP1/BTB/POZ_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  T1-type_BTB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Volt_channel_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:25736 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 25736 ENTREZGENE
PANTHER POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY B MEMBER 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11537 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam BTB_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ion_trans UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kv2channel UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Kcnb1 PhenoGen
PRINTS KCHANNEL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  KV21CHANNEL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  KVCHANNEL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SHABCHANNEL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000046949 RatGTEx
  ENSRNOG00055004620 RatGTEx
  ENSRNOG00060001059 RatGTEx
  ENSRNOG00065013004 RatGTEx
SMART BTB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF54695 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Voltage-gated potassium channels UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0H2UI34 ENTREZGENE, UniProtKB/TrEMBL
  A6JXI9 ENTREZGENE, UniProtKB/TrEMBL
  KCNB1_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-11 Kcnb1  potassium voltage-gated channel subfamily B member 1  Kcnb1  potassium channel, voltage gated Shab-related subfamily B, member 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2015-01-26 Kcnb1  potassium channel, voltage gated Shab-related subfamily B, member 1  Kcnb1  potassium voltage gated channel, Shab-related subfamily, member 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Kcnb1  Potassium voltage gated channel, Shab-related subfamily, member 1      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_product member of the delayed rectifier class of channels 728957