Jag2 (jagged canonical Notch ligand 2) - Rat Genome Database

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Gene: Jag2 (jagged canonical Notch ligand 2) Rattus norvegicus
Analyze
Symbol: Jag2
Name: jagged canonical Notch ligand 2
RGD ID: 2938
Description: Predicted to enable Notch binding activity and growth factor activity. Involved in several processes, including male gonad development; response to hypoxia; and spermatogenesis. Located in perinuclear region of cytoplasm. Human ortholog(s) of this gene implicated in autosomal recessive limb-girdle muscular dystrophy. Orthologous to human JAG2 (jagged canonical Notch ligand 2); PARTICIPATES IN altered Notch signaling pathway; Notch signaling pathway; Notch signaling pathway; INTERACTS WITH (+)-schisandrin B; 2,3,7,8-tetrachlorodibenzodioxine; 3H-1,2-dithiole-3-thione.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: jagged 2; protein jagged-2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr86137,804,133 - 137,826,738 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl6137,804,133 - 137,826,738 (-)EnsemblGRCr8
mRatBN7.26131,983,059 - 132,005,665 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl6131,983,056 - 132,005,818 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx6132,152,615 - 132,174,787 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.06132,442,522 - 132,464,547 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.06131,817,423 - 131,839,474 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.06137,711,144 - 137,733,331 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6137,711,155 - 137,733,026 (-)Ensemblrn6Rnor6.0
Rnor_5.06146,707,326 - 146,729,504 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.46137,909,633 - 137,931,120 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera6129,521,212 - 129,543,266 (-)NCBICelera
RGSC_v3.16137,916,169 - 137,936,985 (-)NCBI
Cytogenetic Map6q32NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
3-methyladenine  (ISO)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-hydroxyphenyl retinamide  (ISO)
6-propyl-2-thiouracil  (EXP,ISO)
ammonium chloride  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
atrazine  (EXP)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[b]fluoranthene  (ISO)
beta-lapachone  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP)
butan-1-ol  (ISO)
C60 fullerene  (EXP)
cadmium dichloride  (ISO)
calciol  (EXP)
calcitriol  (ISO)
cisplatin  (ISO)
cobalt dichloride  (ISO)
cocaine  (EXP)
copper atom  (ISO)
copper(0)  (ISO)
crocidolite asbestos  (ISO)
diarsenic trioxide  (ISO)
dibenz[a,h]anthracene  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (ISO)
disulfiram  (ISO)
doxorubicin  (ISO)
enzalutamide  (ISO)
ethanol  (ISO)
fipronil  (EXP)
FR900359  (ISO)
gentamycin  (EXP)
GSK-J4  (ISO)
isobutanol  (ISO)
ketamine  (EXP)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
methoxychlor  (EXP)
mono(2-ethylhexyl) phthalate  (EXP,ISO)
monocrotaline  (ISO)
Muraglitazar  (EXP)
nickel atom  (ISO)
okadaic acid  (ISO)
ozone  (ISO)
paracetamol  (ISO)
phenethyl isothiocyanate  (ISO)
piroxicam  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
sulfadimethoxine  (EXP)
sulindac sulfide  (ISO)
T-2 toxin  (ISO)
tebuconazole  (ISO)
Tesaglitazar  (EXP)
tetrachloromethane  (EXP)
Theaflavin 3,3'-digallate  (ISO)
thioacetamide  (EXP)
trichostatin A  (ISO)
trimellitic anhydride  (ISO)
triptonide  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function
calcium ion binding  (IEA)
growth factor activity  (IEA,ISO,ISS)
Notch binding  (IBA,IEA,ISO,NAS)
protein binding  (ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Expression pattern of notch1, 2 and 3 and Jagged1 and 2 in lymphoid and stromal thymus components: distinct ligand-receptor interactions in intrathymic T cell development. Felli MP, etal., Int Immunol. 1999 Jul;11(7):1017-25.
2. Cell and molecular biology of Notch. Fiuza UM and Arias AM, J Endocrinol. 2007 Sep;194(3):459-74.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. Human ligands of the Notch receptor. Gray GE, etal., Am J Pathol 1999 Mar;154(3):785-94.
6. Requirement of Notch 1 and its ligand jagged 2 expressions for spermatogenesis in rat and human testes. Hayashi T, etal., J Androl. 2001 Nov-Dec;22(6):999-1011.
7. Expression of the p63 and Notch signaling systems in rat testes during postnatal development: comparison with their expression levels in the epididymis and vas deferens. Hayashi T, etal., J Androl. 2004 Sep-Oct;25(5):692-8.
8. Patterns of Jagged1, Jagged2, Delta-like 1 and Delta-like 3 expression during late embryonic and postnatal brain development suggest multiple functional roles in progenitors and differentiated cells. Irvin DK, etal., J Neurosci Res 2004 Feb 1;75(3):330-43.
9. Notch signalling pathway mediates hair cell development in mammalian cochlea. Lanford PJ, etal., Nat Genet. 1999 Mar;21(3):289-92.
10. Members of the Jagged/Notch gene families are expressed in injured arteries and regulate cell phenotype via alterations in cell matrix and cell-cell interaction. Lindner V, etal., Am J Pathol. 2001 Sep;159(3):875-83. doi: 10.1016/S0002-9440(10)61763-4.
11. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
12. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
13. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
14. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
15. GOA pipeline RGD automated data pipeline
16. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
17. Jagged2: a serrate-like gene expressed during rat embryogenesis. Shawber C, etal., Dev Biol 1996 Nov 25;180(1):370-6.
18. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
19. Chronic hypoxia and rat lung development: analysis by morphometry and directed microarray. Truog WE, etal., Pediatr Res. 2008 Jul;64(1):56-62.
20. Mouse Jagged2 is differentially expressed in hematopoietic progenitors and endothelial cells and promotes the survival and proliferation of hematopoietic progenitors by direct cell-to-cell contact. Tsai S, etal., Blood. 2000 Aug 1;96(3):950-7.
Additional References at PubMed
PMID:9315665   PMID:9531541   PMID:10958687   PMID:15721140   PMID:15886206   PMID:16607638   PMID:19503073   PMID:23232913   PMID:24098462   PMID:24907271   PMID:38277398  


Genomics

Comparative Map Data
Jag2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr86137,804,133 - 137,826,738 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl6137,804,133 - 137,826,738 (-)EnsemblGRCr8
mRatBN7.26131,983,059 - 132,005,665 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl6131,983,056 - 132,005,818 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx6132,152,615 - 132,174,787 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.06132,442,522 - 132,464,547 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.06131,817,423 - 131,839,474 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.06137,711,144 - 137,733,331 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6137,711,155 - 137,733,026 (-)Ensemblrn6Rnor6.0
Rnor_5.06146,707,326 - 146,729,504 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.46137,909,633 - 137,931,120 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera6129,521,212 - 129,543,266 (-)NCBICelera
RGSC_v3.16137,916,169 - 137,936,985 (-)NCBI
Cytogenetic Map6q32NCBI
JAG2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3814105,140,995 - 105,168,776 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl14105,140,982 - 105,168,919 (-)Ensemblhg38GRCh38
GRCh3714105,607,332 - 105,635,113 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3614104,679,121 - 104,706,206 (-)NCBIBuild 36Build 36hg18NCBI36
Build 3414104,679,120 - 104,706,206NCBI
Celera1485,661,503 - 85,688,392 (-)NCBICelera
Cytogenetic Map14q32.33NCBI
HuRef1485,798,697 - 85,815,481 (-)NCBIHuRef
CHM1_114105,545,299 - 105,572,922 (-)NCBICHM1_1
T2T-CHM13v2.01499,382,854 - 99,410,701 (-)NCBIT2T-CHM13v2.0
Jag2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3912112,871,439 - 112,893,437 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl12112,871,439 - 112,893,396 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm3812112,907,803 - 112,929,812 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl12112,907,819 - 112,929,776 (-)Ensemblmm10GRCm38
MGSCv3712114,146,801 - 114,167,706 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv3612113,356,398 - 113,377,303 (-)NCBIMGSCv36mm8
Celera12114,118,903 - 114,139,458 (-)NCBICelera
Cytogenetic Map12F1NCBI
cM Map1261.37NCBI
Jag2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555383,421,685 - 3,433,842 (-)Ensembl
ChiLan1.0NW_0049555383,421,685 - 3,433,829 (-)NCBIChiLan1.0ChiLan1.0
JAG2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v215106,321,986 - 106,348,518 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan114105,538,488 - 105,565,020 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01485,785,586 - 85,812,056 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.114105,569,837 - 105,604,408 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl14105,569,837 - 105,585,878 (-)EnsemblpanPan2panpan1.1
JAG2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1872,535,539 - 72,553,531 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl872,535,107 - 72,550,322 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha872,047,599 - 72,068,957 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0872,823,360 - 72,848,984 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl872,822,931 - 72,856,860 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1872,503,851 - 72,525,225 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0872,554,984 - 72,576,363 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0872,944,852 - 72,966,232 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Jag2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244086401,534,532 - 1,551,659 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936621366,616 - 380,618 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936621363,489 - 380,616 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JAG2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa10.27131,225,201 - 131,245,220 (-)NCBISscrofa10.2Sscrofa10.2susScr3
JAG2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12483,050,412 - 83,081,982 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2483,051,368 - 83,076,820 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366605370,482,903 - 70,500,481 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Jag2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624734308,375 - 327,604 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_004624734308,371 - 327,496 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Jag2
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v17130,506,433 - 130,528,632 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Jag2
168 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:135
Count of miRNA genes:112
Interacting mature miRNAs:122
Transcripts:ENSRNOT00000019213
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4145118Mcs26Mammary carcinoma susceptibility QTL 260.0001mammary gland integrity trait (VT:0010552)post-insult time to mammary tumor formation (CMO:0000345)6112483610147156653Rat
1331797Bp213Blood pressure QTL 2133.291arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)6114241077147156653Rat
1641917Colcr5Colorectal carcinoma resistance QTL 53.180.0009intestine integrity trait (VT:0010554)benign colorectal tumor number (CMO:0001795)698944780143944780Rat
71111Iddm8Insulin dependent diabetes mellitus QTL 81.90.002blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)6110921244147156653Rat
724524Uae2Urinary albumin excretion QTL 22.70.0005urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)679198463144254945Rat
1358355Srcrt4Stress Responsive Cort QTL 46.39blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)6106095977147156653Rat
2303624Vencon5Ventilatory control QTL 54.45respiration trait (VT:0001943)minute ventilation (CMO:0000132)693778632138778632Rat
737976Pia24Pristane induced arthritis QTL 24joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)6118366855147156653Rat
2312560Pur20Proteinuria QTL 202.10.005urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)6131392689143944780Rat
2313399Anxrr28Anxiety related response QTL 28aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)6101593607138161926Rat
1298087Iddm18Insulin dependent diabetes mellitus QTL 180.0001urine glucose amount (VT:0001758)percentage of study population developing diabetes mellitus during a period of time (CMO:0001114)6122236101147156653Rat
12801471Schws9Schwannoma susceptibility QTL 9nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)6101593607146593607Rat
2293085Iddm29Insulin dependent diabetes mellitus QTL 297.66blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)6121444670147156653Rat

Markers in Region
AI101320  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr86137,810,046 - 137,810,439 (+)Marker Load Pipeline
mRatBN7.26131,988,972 - 131,989,365 (+)MAPPERmRatBN7.2
Rnor_6.06137,717,061 - 137,717,453NCBIRnor6.0
Rnor_5.06146,713,243 - 146,713,635UniSTSRnor5.0
RGSC_v3.46137,914,765 - 137,915,157UniSTSRGSC3.4
Celera6129,527,129 - 129,527,521UniSTS
RH 3.4 Map6783.1UniSTS
Cytogenetic Map6q32UniSTS
UniSTS:465459  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr86137,805,684 - 137,805,962 (+)Marker Load Pipeline
mRatBN7.26131,984,610 - 131,984,888 (+)MAPPERmRatBN7.2
Rnor_6.06137,712,699 - 137,712,976NCBIRnor6.0
Rnor_5.06146,708,881 - 146,709,158UniSTSRnor5.0
RGSC_v3.46137,910,403 - 137,910,680UniSTSRGSC3.4
Celera6129,522,767 - 129,523,044UniSTS
Cytogenetic Map6q32UniSTS
D17S1789  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2987,972,545 - 87,973,112 (+)MAPPERmRatBN7.2
mRatBN7.26131,984,729 - 131,985,679 (+)MAPPERmRatBN7.2
Rnor_6.06137,712,818 - 137,713,767NCBIRnor6.0
Rnor_6.0994,396,513 - 94,397,079NCBIRnor6.0
Rnor_5.0994,119,127 - 94,119,693UniSTSRnor5.0
Rnor_5.06146,709,000 - 146,709,949UniSTSRnor5.0
RGSC_v3.46137,910,522 - 137,911,471UniSTSRGSC3.4
RGSC_v3.4986,112,181 - 86,112,747UniSTSRGSC3.4
Celera985,384,401 - 85,384,967UniSTS
Celera6129,522,886 - 129,523,835UniSTS
Cytogenetic Map9q35UniSTS
Cytogenetic Map6q32UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 160 91 90 59 84 59 6 348 184 11 137 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000019213   ⟹   ENSRNOP00000019213
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl6137,804,133 - 137,826,738 (-)Ensembl
mRatBN7.2 Ensembl6131,983,056 - 132,005,818 (-)Ensembl
Rnor_6.0 Ensembl6137,711,155 - 137,733,026 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000100725   ⟹   ENSRNOP00000083204
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl6137,804,133 - 137,826,738 (-)Ensembl
mRatBN7.2 Ensembl6131,983,056 - 132,005,818 (-)Ensembl
RefSeq Acc Id: NM_001375303   ⟹   NP_001362232
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86137,804,133 - 137,826,336 (-)NCBI
mRatBN7.26131,983,059 - 132,005,263 (-)NCBI
RefSeq Acc Id: NM_001414899   ⟹   NP_001401828
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86137,804,133 - 137,826,738 (-)NCBI
mRatBN7.26131,983,059 - 132,005,665 (-)NCBI
RefSeq Acc Id: XM_039111823   ⟹   XP_038967751
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86137,804,149 - 137,826,533 (-)NCBI
mRatBN7.26131,983,059 - 132,005,359 (-)NCBI
RefSeq Acc Id: XM_039111824   ⟹   XP_038967752
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86137,810,415 - 137,826,481 (-)NCBI
mRatBN7.26131,989,337 - 132,005,359 (-)NCBI
RefSeq Acc Id: XM_063261573   ⟹   XP_063117643
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86137,804,149 - 137,826,533 (-)NCBI
Ensembl Acc Id: ENSRNOP00000019213   ⟸   ENSRNOT00000019213
RefSeq Acc Id: NP_001362232   ⟸   NM_001375303
- Peptide Label: isoform 2
- UniProtKB: A6KBW9 (UniProtKB/TrEMBL),   A6KBX0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038967751   ⟸   XM_039111823
- Peptide Label: isoform X2
- UniProtKB: A0A8I5ZUZ8 (UniProtKB/TrEMBL),   A6KBX0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038967752   ⟸   XM_039111824
- Peptide Label: isoform X3
Ensembl Acc Id: ENSRNOP00000083204   ⟸   ENSRNOT00000100725
RefSeq Acc Id: NP_001401828   ⟸   NM_001414899
- Peptide Label: isoform 1 precursor
- UniProtKB: E9PU23 (UniProtKB/TrEMBL),   A6KBX0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063117643   ⟸   XM_063261573
- Peptide Label: isoform X1
- UniProtKB: A6KBX0 (UniProtKB/TrEMBL)
Protein Domains
DSL   EGF-like

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P97607-F1-model_v2 AlphaFold P97607 1-1202 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2938 AgrOrtholog
BioCyc Gene G2FUF-35770 BioCyc
Ensembl Genes ENSRNOG00000013927 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000019213 ENTREZGENE
  ENSRNOT00000100725 ENTREZGENE
Gene3D-CATH 2.10.25.140 UniProtKB/Swiss-Prot
  2.60.40.3510 UniProtKB/Swiss-Prot
  Laminin UniProtKB/Swiss-Prot
InterPro DSL UniProtKB/Swiss-Prot
  EGF-like_Ca-bd_dom UniProtKB/Swiss-Prot
  EGF-like_CS UniProtKB/Swiss-Prot
  EGF-like_dom UniProtKB/Swiss-Prot
  EGF-type_Asp/Asn_hydroxyl_site UniProtKB/Swiss-Prot
  EGF_Ca-bd_CS UniProtKB/Swiss-Prot
  Growth_fac_rcpt_cys_sf UniProtKB/Swiss-Prot
  JAG1_1/2_dom UniProtKB/Swiss-Prot
  Jagged/Serrate UniProtKB/Swiss-Prot
  NOTCH1_EGF-like UniProtKB/Swiss-Prot
  Notch_ligand_N UniProtKB/Swiss-Prot
  VWF_dom UniProtKB/Swiss-Prot
NCBI Gene 29147 ENTREZGENE
PANTHER CYTOCHROME C OXIDASE POLYPEPTIDE VIC-2 UniProtKB/Swiss-Prot
  DELTA-LIKE PROTEIN UniProtKB/Swiss-Prot
Pfam DL-JAG_EGF-like UniProtKB/Swiss-Prot
  DSL UniProtKB/Swiss-Prot
  EGF UniProtKB/Swiss-Prot
  EGF_CA UniProtKB/Swiss-Prot
  hEGF UniProtKB/Swiss-Prot
  JAG1 UniProtKB/Swiss-Prot
  MNNL UniProtKB/Swiss-Prot
PhenoGen Jag2 PhenoGen
PRINTS EGFBLOOD UniProtKB/Swiss-Prot
  JAGGEDFAMILY UniProtKB/Swiss-Prot
PROSITE ASX_HYDROXYL UniProtKB/Swiss-Prot
  DSL UniProtKB/Swiss-Prot
  EGF_1 UniProtKB/Swiss-Prot
  EGF_2 UniProtKB/Swiss-Prot
  EGF_3 UniProtKB/Swiss-Prot
  EGF_CA UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000013927 RatGTEx
SMART DSL UniProtKB/Swiss-Prot
  EGF UniProtKB/Swiss-Prot
  EGF_CA UniProtKB/Swiss-Prot
  VWC_out UniProtKB/Swiss-Prot
Superfamily-SCOP EGF/Laminin UniProtKB/Swiss-Prot
  SSF57184 UniProtKB/Swiss-Prot
TIGR TC205341
UniProt A0A8I5ZUZ8 ENTREZGENE, UniProtKB/TrEMBL
  A6KBW9 ENTREZGENE, UniProtKB/TrEMBL
  A6KBX0 ENTREZGENE, UniProtKB/TrEMBL
  E9PU23 ENTREZGENE, UniProtKB/TrEMBL
  JAG2_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-04-10 Jag2  jagged canonical Notch ligand 2  Jag2  jagged 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Jag2  jagged 2       Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in the apical ectodermal ridge and thymus 69864
gene_process may be involved in Notch directed T-cell fate 69864