Itsn1 (intersectin 1) - Rat Genome Database

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Gene: Itsn1 (intersectin 1) Rattus norvegicus
Analyze
Symbol: Itsn1
Name: intersectin 1
RGD ID: 2935
Description: Predicted to enable kinase activator activity; proline-rich region binding activity; and protein-macromolecule adaptor activity. Involved in positive regulation of dendritic spine development; positive regulation of transport; and regulation of synapse organization. Located in several cellular components, including clathrin-coated pit; dendrite; and neuronal cell body. Is active in glutamatergic synapse; postsynaptic actin cytoskeleton; and postsynaptic endocytic zone. Orthologous to human ITSN1 (intersectin 1); PARTICIPATES IN clathrin-dependent synaptic vesicle endocytosis; ephrin - ephrin receptor bidirectional signaling axis; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,6-dinitrotoluene; 3,3',4,4',5-pentachlorobiphenyl.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: EH domain and SH3 domain regulator of endocytosis 1; EHSH1; intersectin (SH3 domain protein 1A); intersectin 1 (SH3 domain protein 1A); intersectin 1 (SH3 domain protein); intersectin-1; intersectin-1-like; intersection (SH3 domain protein 1A); Itsn; LOC100911851
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81144,464,515 - 44,646,598 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1144,513,186 - 44,646,598 (+)EnsemblGRCr8
mRatBN7.21130,978,590 - 31,160,645 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1130,978,590 - 31,160,645 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1139,672,533 - 39,854,583 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01132,343,963 - 32,526,016 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01131,506,203 - 31,688,572 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01131,943,119 - 32,069,249 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1131,893,489 - 32,069,249 (+)Ensemblrn6Rnor6.0
Rnor_5.01135,547,331 - 35,672,959 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41131,721,528 - 31,901,963 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1130,687,099 - 30,812,424 (+)NCBICelera
RGSC_v3.11131,815,217 - 31,903,071 (+)NCBI
Cytogenetic Map11q11NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
(1->4)-beta-D-glucan  (ISO)
1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene  (ISO)
1,2-dichloroethane  (ISO)
17beta-estradiol  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,4'-trichlorobiphenyl  (ISO)
2,6-dinitrotoluene  (EXP)
2-butoxyethanol  (ISO)
2-methylcholine  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP,ISO)
3,4-methylenedioxymethamphetamine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxynon-2-enal  (ISO)
5-fluorouracil  (ISO)
acrylamide  (EXP)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
all-trans-retinoic acid  (ISO)
allethrin  (EXP)
ammonium chloride  (EXP)
Aroclor 1254  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[e]pyrene  (ISO)
bisphenol A  (EXP)
bisphenol AF  (ISO)
Bisphenol B  (ISO)
butanal  (ISO)
Butylbenzyl phthalate  (ISO)
C60 fullerene  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
carbon nanotube  (ISO)
chlorpyrifos  (ISO)
cisplatin  (ISO)
clobetasol  (ISO)
clothianidin  (ISO)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
crocidolite asbestos  (ISO)
cyclosporin A  (ISO)
cyhalothrin  (EXP)
cypermethrin  (EXP)
decabromodiphenyl ether  (EXP)
dexamethasone  (EXP)
Diacetoxyscirpenol  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (ISO)
dieldrin  (ISO)
ethanol  (ISO)
fenvalerate  (EXP)
fipronil  (EXP)
formaldehyde  (ISO)
gentamycin  (EXP)
glyphosate  (ISO)
hexadecanoic acid  (ISO)
hydralazine  (ISO)
ivermectin  (ISO)
lidocaine  (EXP)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
methapyrilene  (ISO)
methoxychlor  (EXP)
nickel atom  (ISO)
oxaliplatin  (EXP)
ozone  (EXP)
paracetamol  (EXP)
PCB138  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenobarbital  (ISO)
pirinixic acid  (ISO)
potassium chromate  (ISO)
pyrethrins  (EXP)
quercetin  (ISO)
sodium arsenite  (ISO)
sodium fluoride  (ISO)
sunitinib  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (EXP,ISO)
tetrachloromethane  (ISO)
tetraphene  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
topotecan  (EXP)
trichloroethene  (EXP)
triptonide  (ISO)
valproic acid  (EXP,ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Dynamics and nanoscale organization of the postsynaptic endocytic zone at excitatory synapses. Catsburg LA, etal., Elife. 2022 Jan 24;11:e74387. doi: 10.7554/eLife.74387.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. Neuronal distribution of EHSH1/intersectin: molecular linker between clathrin-mediated endocytosis and signaling pathways. Ma YJ, etal., J Neurosci Res. 2003 Feb 15;71(4):468-77. doi: 10.1002/jnr.10500.
5. Intersectin-1L nucleotide exchange factor regulates secretory granule exocytosis by activating Cdc42. Malacombe M, etal., EMBO J. 2006 Aug 9;25(15):3494-503. doi: 10.1038/sj.emboj.7601247. Epub 2006 Jul 27.
6. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
7. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
8. EHSH1/intersectin, a protein that contains EH and SH3 domains and binds to dynamin and SNAP-25. A protein connection between exocytosis and endocytosis? Okamoto M, etal., J Biol Chem 1999 Jun 25;274(26):18446-54.
9. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
10. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
11. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
12. Synaptic vesicle endocytosis. Saheki Y and De Camilli P, Cold Spring Harb Perspect Biol. 2012 Sep 1;4(9):a005645. doi: 10.1101/cshperspect.a005645.
13. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
14. Intersectin regulates dendritic spine development and somatodendritic endocytosis but not synaptic vesicle recycling in hippocampal neurons. Thomas S, etal., J Biol Chem. 2009 May 1;284(18):12410-9. doi: 10.1074/jbc.M809746200. Epub 2009 Mar 3.
15. Composition of isolated synaptic boutons reveals the amounts of vesicle trafficking proteins. Wilhelm BG, etal., Science. 2014 May 30;344(6187):1023-8. doi: 10.1126/science.1252884.
Additional References at PubMed
PMID:11584276   PMID:11744688   PMID:16394100   PMID:16903783   PMID:17875942   PMID:18676989   PMID:20448150   PMID:20946875   PMID:21088884   PMID:23633571   PMID:25783631   PMID:26437238  
PMID:29476059   PMID:29599122   PMID:29887380   PMID:36307995  


Genomics

Comparative Map Data
Itsn1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81144,464,515 - 44,646,598 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1144,513,186 - 44,646,598 (+)EnsemblGRCr8
mRatBN7.21130,978,590 - 31,160,645 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1130,978,590 - 31,160,645 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1139,672,533 - 39,854,583 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01132,343,963 - 32,526,016 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01131,506,203 - 31,688,572 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01131,943,119 - 32,069,249 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1131,893,489 - 32,069,249 (+)Ensemblrn6Rnor6.0
Rnor_5.01135,547,331 - 35,672,959 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41131,721,528 - 31,901,963 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1130,687,099 - 30,812,424 (+)NCBICelera
RGSC_v3.11131,815,217 - 31,903,071 (+)NCBI
Cytogenetic Map11q11NCBI
ITSN1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382133,642,501 - 33,899,861 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2133,642,400 - 33,899,861 (+)Ensemblhg38GRCh38
GRCh372135,014,807 - 35,272,165 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362133,936,654 - 34,183,479 (+)NCBIBuild 36Build 36hg18NCBI36
Build 342133,936,653 - 34,183,479NCBI
Celera2120,214,405 - 20,461,193 (+)NCBICelera
Cytogenetic Map21q22.11NCBI
HuRef2120,493,109 - 20,739,668 (+)NCBIHuRef
CHM1_12134,577,248 - 34,824,084 (+)NCBICHM1_1
T2T-CHM13v2.02132,024,315 - 32,281,564 (+)NCBIT2T-CHM13v2.0
Itsn1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391691,526,198 - 91,717,479 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1691,526,169 - 91,717,485 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381691,729,310 - 91,920,591 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1691,729,281 - 91,920,597 (+)Ensemblmm10GRCm38
MGSCv371691,729,616 - 91,920,824 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361691,671,052 - 91,800,868 (+)NCBIMGSCv36mm8
Celera1692,808,009 - 93,004,876 (+)NCBICelera
Cytogenetic Map16C4NCBI
cM Map1653.28NCBI
Itsn1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540733,113,319 - 33,275,675 (+)Ensembl
ChiLan1.0NW_00495540733,056,004 - 33,275,681 (+)NCBIChiLan1.0ChiLan1.0
ITSN1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22229,759,728 - 30,017,340 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12124,617,929 - 24,875,764 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02120,009,385 - 20,266,835 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12133,381,640 - 33,625,603 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2133,457,081 - 33,625,248 (+)EnsemblpanPan2panpan1.1
ITSN1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13129,144,754 - 29,360,134 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3128,243,620 - 28,459,926 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.03128,451,006 - 28,667,391 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3128,451,116 - 28,661,479 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13128,317,804 - 28,534,014 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03128,331,715 - 28,548,460 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03128,831,446 - 29,047,794 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Itsn1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440497128,789,742 - 28,977,174 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365008,468,940 - 8,612,942 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365008,490,514 - 8,678,127 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ITSN1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl13197,249,061 - 197,481,245 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.113197,301,515 - 197,492,537 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213207,205,545 - 207,267,672 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ITSN1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1258,298,529 - 58,543,297 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl258,301,399 - 58,543,281 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_023666071805,376 - 1,047,516 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Itsn1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474521,906,187 - 22,050,822 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462474521,847,593 - 22,055,141 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Itsn1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1452,692,134 - 52,868,443 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Itsn1
577 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:266
Count of miRNA genes:123
Interacting mature miRNAs:149
Transcripts:ENSRNOT00000042750, ENSRNOT00000047843
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300147Bp187Blood pressure QTL 1873.67arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)112252474682951192Rat
1598841Memor7Memory QTL 7exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)113330600878306008Rat
1598842Glom10Glomerulus QTL 103.4kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)11381815448818154Rat
1598811Bp291Blood pressure QTL 2911.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)113330600878306008Rat
634339Niddm50Non-insulin dependent diabetes mellitus QTL 503.32blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)111080612555806125Rat
634341Bw121Body weight QTL 1213.56abdominal fat pad mass (VT:1000711)abdominal fat pad weight (CMO:0000088)113532319955805892Rat
8694376Bw156Body weight QTL 1562.250.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)113674945981749459Rat
10755497Bp388Blood pressure QTL 3882.76arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)113294306789836615Rat
724517Uae18Urinary albumin excretion QTL 183.7urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)112995899657754989Rat
2290451Scl58Serum cholesterol level QTL 583.48blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)112631803155806125Rat
1300130Rf20Renal function QTL 204.44kidney glomerulus integrity trait (VT:0010546)kidney glomerulus diameter (CMO:0001166)113191546976915469Rat
10058952Gmadr6Adrenal mass QTL 62.290.0072adrenal gland mass (VT:0010420)both adrenal glands wet weight to body weight ratio (CMO:0002411)113642841681428416Rat
1600394Edcs1Endometrial carcinoma susceptibility QTL12.90.04uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)111282315257823152Rat
1558659Tescar1Testicular tumor resistance QTL 13.9testis integrity trait (VT:0010572)percentage of study population developing testis tumors during a period of time (CMO:0001261)113461876079618760Rat
724563Uae10Urinary albumin excretion QTL 106urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)112019354996351019Rat
9589032Epfw10Epididymal fat weight QTL 109.290.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)113674945981749459Rat
9590313Scort20Serum corticosterone level QTL 206.510.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)113674945981749459Rat
8694424Bw162Body weight QTL 1623.80.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)113674945981749459Rat
631510Spl2Serum phospholipid level QTL 24.1blood phospholipid amount (VT:0006084)serum phospholipid level (CMO:0001171)112755668572556685Rat

Markers in Region
D11Rat13  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21131,071,112 - 31,071,247 (+)MAPPERmRatBN7.2
Rnor_6.01131,987,001 - 31,987,134NCBIRnor6.0
Rnor_5.01135,591,213 - 35,591,346UniSTSRnor5.0
RGSC_v3.41131,820,215 - 31,820,348UniSTSRGSC3.4
RGSC_v3.41131,820,214 - 31,820,348RGDRGSC3.4
Celera1130,730,986 - 30,731,119UniSTS
RGSC_v3.11131,859,087 - 31,859,220RGD
RH 3.4 Map11202.3RGD
RH 3.4 Map11202.3UniSTS
FHH x ACI Map1112.19RGD
FHH x ACI Map1112.19UniSTS
Cytogenetic Map11q11UniSTS
D11Got26  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_5.01135,640,985 - 35,641,186NCBIRnor5.0
Rnor_5.01135,640,986 - 35,641,186NCBIRnor5.0
RGSC_v3.41131,869,988 - 31,870,188RGDRGSC3.4
RGSC_v3.41131,869,989 - 31,870,188UniSTSRGSC3.4
Celera1130,779,811 - 30,780,014UniSTS
RGSC_v3.11131,908,865 - 31,909,064RGD
RH 3.4 Map11203.1UniSTS
RH 3.4 Map11203.1RGD
RH 2.0 Map11453.4RGD
Cytogenetic Map11q11UniSTS
RH140585  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81144,556,582 - 44,556,771 (+)Marker Load Pipeline
mRatBN7.21131,070,630 - 31,070,819 (+)MAPPERmRatBN7.2
Rnor_6.01131,986,519 - 31,986,707NCBIRnor6.0
Rnor_5.01135,590,731 - 35,590,919UniSTSRnor5.0
RGSC_v3.41131,819,733 - 31,819,921UniSTSRGSC3.4
Celera1130,730,504 - 30,730,692UniSTS
RH 3.4 Map11176.8UniSTS
Cytogenetic Map11q11UniSTS
BI283741  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21131,096,782 - 31,096,948 (+)MAPPERmRatBN7.2
Rnor_6.01132,013,163 - 32,013,328NCBIRnor6.0
Rnor_5.01135,616,875 - 35,617,040UniSTSRnor5.0
RGSC_v3.41131,845,877 - 31,846,042UniSTSRGSC3.4
Celera1130,756,527 - 30,756,692UniSTS
RH 3.4 Map11198.1UniSTS
Cytogenetic Map11q11UniSTS
RH135361  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81144,487,179 - 44,487,410 (+)Marker Load Pipeline
mRatBN7.21131,001,225 - 31,001,456 (+)MAPPERmRatBN7.2
Rnor_6.01131,917,115 - 31,917,345NCBIRnor6.0
Rnor_5.01135,521,327 - 35,521,557UniSTSRnor5.0
RGSC_v3.41131,750,342 - 31,750,572UniSTSRGSC3.4
Celera1130,661,081 - 30,661,311UniSTS
RH 3.4 Map11200.5UniSTS
Cytogenetic Map11q11UniSTS
REN86881  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21131,114,822 - 31,115,068 (+)MAPPERmRatBN7.2
Rnor_6.01127,576,301 - 27,576,546NCBIRnor6.0
Rnor_6.01132,031,204 - 32,031,449NCBIRnor6.0
Rnor_5.01135,634,916 - 35,635,161UniSTSRnor5.0
Rnor_5.01131,196,421 - 31,196,666UniSTSRnor5.0
RGSC_v3.41131,863,918 - 31,864,163UniSTSRGSC3.4
Cytogenetic Map11q11UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 164 91 90 59 92 59 6 356 192 11 143 81 92 31 17 17

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001136096 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_019227 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039088246 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039088247 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039088248 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039088249 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039088250 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039088251 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063270443 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063270444 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063270445 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063270446 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC123507 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC142009 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF127798 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF132672 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473989 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000011 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000042750   ⟹   ENSRNOP00000044773
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1144,513,186 - 44,602,170 (+)Ensembl
mRatBN7.2 Ensembl1130,978,590 - 31,116,225 (+)Ensembl
Rnor_6.0 Ensembl1131,893,489 - 32,069,249 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000047843   ⟹   ENSRNOP00000045513
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1144,513,186 - 44,602,170 (+)Ensembl
mRatBN7.2 Ensembl1131,027,230 - 31,115,100 (+)Ensembl
Rnor_6.0 Ensembl1131,943,119 - 32,031,481 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000085965
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1127,568,537 - 27,577,691 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000087733
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1127,566,879 - 27,577,691 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000089993
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1127,571,533 - 27,577,691 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000096706   ⟹   ENSRNOP00000097531
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1144,513,186 - 44,639,141 (+)Ensembl
mRatBN7.2 Ensembl1130,978,590 - 31,160,645 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000096792   ⟹   ENSRNOP00000095645
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1144,513,186 - 44,646,598 (+)Ensembl
mRatBN7.2 Ensembl1130,978,590 - 31,160,645 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000110949   ⟹   ENSRNOP00000089593
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1144,632,547 - 44,646,598 (+)Ensembl
mRatBN7.2 Ensembl1131,146,593 - 31,160,645 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000114620   ⟹   ENSRNOP00000077439
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1144,514,781 - 44,646,598 (+)Ensembl
mRatBN7.2 Ensembl1131,028,827 - 31,160,645 (+)Ensembl
RefSeq Acc Id: NM_001136096   ⟹   NP_001129568
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81144,464,547 - 44,646,598 (+)NCBI
mRatBN7.21130,978,590 - 31,160,645 (+)NCBI
Rnor_6.01131,943,121 - 32,069,249 (+)NCBI
Rnor_5.01135,547,331 - 35,672,959 (+)NCBI
RGSC_v3.41131,721,528 - 31,901,963 (+)RGD
Celera1130,687,101 - 30,812,424 (+)NCBI
Sequence:
RefSeq Acc Id: NM_019227   ⟹   NP_062100
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81144,464,547 - 44,602,171 (+)NCBI
mRatBN7.21130,978,590 - 31,116,225 (+)NCBI
Rnor_6.01131,943,119 - 32,031,481 (+)NCBI
Rnor_5.01135,547,331 - 35,672,959 (+)NCBI
RGSC_v3.41131,721,528 - 31,901,963 (+)RGD
Celera1130,687,099 - 30,792,058 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039088246   ⟹   XP_038944174
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81144,464,566 - 44,646,598 (+)NCBI
mRatBN7.21130,978,689 - 31,153,195 (+)NCBI
RefSeq Acc Id: XM_039088247   ⟹   XP_038944175
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81144,465,434 - 44,646,598 (+)NCBI
mRatBN7.21130,979,480 - 31,154,490 (+)NCBI
RefSeq Acc Id: XM_039088248   ⟹   XP_038944176
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81144,464,601 - 44,583,059 (+)NCBI
mRatBN7.21130,978,689 - 31,097,115 (+)NCBI
RefSeq Acc Id: XM_039088249   ⟹   XP_038944177
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81144,464,545 - 44,583,059 (+)NCBI
mRatBN7.21130,978,689 - 31,097,115 (+)NCBI
RefSeq Acc Id: XM_039088250   ⟹   XP_038944178
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81144,464,608 - 44,588,891 (+)NCBI
mRatBN7.21130,978,689 - 31,102,947 (+)NCBI
RefSeq Acc Id: XM_039088251   ⟹   XP_038944179
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81144,464,605 - 44,574,802 (+)NCBI
mRatBN7.21130,978,689 - 31,088,160 (+)NCBI
RefSeq Acc Id: XM_063270443   ⟹   XP_063126513
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81144,465,435 - 44,646,598 (+)NCBI
RefSeq Acc Id: XM_063270444   ⟹   XP_063126514
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81144,534,246 - 44,646,598 (+)NCBI
RefSeq Acc Id: XM_063270445   ⟹   XP_063126515
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81144,464,515 - 44,602,171 (+)NCBI
RefSeq Acc Id: XM_063270446   ⟹   XP_063126516
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81144,534,246 - 44,602,171 (+)NCBI
RefSeq Acc Id: NP_001129568   ⟸   NM_001136096
- Peptide Label: isoform a
- UniProtKB: Q9WVE9 (UniProtKB/Swiss-Prot),   F1M823 (UniProtKB/Swiss-Prot),   Q9WVE1 (UniProtKB/Swiss-Prot),   D3ZV52 (UniProtKB/TrEMBL),   A0A8I5Y9J0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_062100   ⟸   NM_019227
- Peptide Label: isoform b
- UniProtKB: A0A8L2QLK0 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000045513   ⟸   ENSRNOT00000047843
Ensembl Acc Id: ENSRNOP00000044773   ⟸   ENSRNOT00000042750
RefSeq Acc Id: XP_038944174   ⟸   XM_039088246
- Peptide Label: isoform X1
- UniProtKB: A0A8I6ARZ8 (UniProtKB/TrEMBL),   A0A8I5Y9J0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038944178   ⟸   XM_039088250
- Peptide Label: isoform X8
- UniProtKB: A0A8L2QM65 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038944176   ⟸   XM_039088248
- Peptide Label: isoform X6
RefSeq Acc Id: XP_038944177   ⟸   XM_039088249
- Peptide Label: isoform X7
RefSeq Acc Id: XP_038944179   ⟸   XM_039088251
- Peptide Label: isoform X9
RefSeq Acc Id: XP_038944175   ⟸   XM_039088247
- Peptide Label: isoform X1
- UniProtKB: A0A8I6ARZ8 (UniProtKB/TrEMBL),   A0A8I5Y9J0 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000077439   ⟸   ENSRNOT00000114620
Ensembl Acc Id: ENSRNOP00000089593   ⟸   ENSRNOT00000110949
Ensembl Acc Id: ENSRNOP00000097531   ⟸   ENSRNOT00000096706
Ensembl Acc Id: ENSRNOP00000095645   ⟸   ENSRNOT00000096792
RefSeq Acc Id: XP_063126515   ⟸   XM_063270445
- Peptide Label: isoform X4
- UniProtKB: A0A8L2QLK0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063126513   ⟸   XM_063270443
- Peptide Label: isoform X2
- UniProtKB: Q9WVE9 (UniProtKB/Swiss-Prot),   Q9WVE1 (UniProtKB/Swiss-Prot),   F1M823 (UniProtKB/Swiss-Prot),   D3ZV52 (UniProtKB/Swiss-Prot),   A0A8I5Y9J0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063126514   ⟸   XM_063270444
- Peptide Label: isoform X3
- UniProtKB: A0A8I5Y9J0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063126516   ⟸   XM_063270446
- Peptide Label: isoform X5
- UniProtKB: A0A8L2QLK0 (UniProtKB/TrEMBL)
Protein Domains
C2   DH   EF-hand   EH   PH   SH3

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9WVE9-F1-model_v2 AlphaFold Q9WVE9 1-1713 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2935 AgrOrtholog
BIND 130893
BioCyc Gene G2FUF-21874 BioCyc
Ensembl Genes ENSRNOG00000002001 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOG00000061155 Ensembl
Ensembl Transcript ENSRNOT00000042750 ENTREZGENE
  ENSRNOT00000096706 ENTREZGENE
  ENSRNOT00000096792 ENTREZGENE
  ENSRNOT00000096792.1 UniProtKB/Swiss-Prot
Gene3D-CATH 1.20.900.10 UniProtKB/Swiss-Prot
  2.30.29.30 UniProtKB/Swiss-Prot
  2.60.40.150 UniProtKB/Swiss-Prot
  EF-hand UniProtKB/Swiss-Prot
  SH3 Domains UniProtKB/Swiss-Prot
InterPro C2_dom UniProtKB/Swiss-Prot
  C2_domain_sf UniProtKB/Swiss-Prot
  DBL_dom_sf UniProtKB/Swiss-Prot
  DH-domain UniProtKB/Swiss-Prot
  EF-hand-dom_pair UniProtKB/Swiss-Prot
  EF_Hand_1_Ca_BS UniProtKB/Swiss-Prot
  EF_hand_dom UniProtKB/Swiss-Prot
  EH_dom UniProtKB/Swiss-Prot
  Endocytic_GEF_Adapter UniProtKB/Swiss-Prot
  GDS_CDC24_CS UniProtKB/Swiss-Prot
  INTAP UniProtKB/Swiss-Prot
  PH-like_dom_sf UniProtKB/Swiss-Prot
  PH_domain UniProtKB/Swiss-Prot
  SH3-like_dom_sf UniProtKB/Swiss-Prot
  SH3_domain UniProtKB/Swiss-Prot
KEGG Report rno:29491 UniProtKB/Swiss-Prot
NCBI Gene 29491 ENTREZGENE
PANTHER INTERSECTIN-2 ISOFORM X1 UniProtKB/Swiss-Prot
  RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR AT 64C, ISOFORM A UniProtKB/Swiss-Prot
Pfam EF-hand_4 UniProtKB/Swiss-Prot
  INTAP UniProtKB/Swiss-Prot
  PF00168 UniProtKB/Swiss-Prot
  PH_13 UniProtKB/Swiss-Prot
  RhoGEF UniProtKB/Swiss-Prot
  SH3_1 UniProtKB/Swiss-Prot
  SH3_2 UniProtKB/Swiss-Prot
  SH3_9 UniProtKB/Swiss-Prot
PhenoGen Itsn1 PhenoGen
PRINTS SH3DOMAIN UniProtKB/Swiss-Prot
PROSITE DH_1 UniProtKB/Swiss-Prot
  DH_2 UniProtKB/Swiss-Prot
  EF_HAND_1 UniProtKB/Swiss-Prot
  EF_HAND_2 UniProtKB/Swiss-Prot
  PH_DOMAIN UniProtKB/Swiss-Prot
  PS50004 UniProtKB/Swiss-Prot
  PS50031 UniProtKB/Swiss-Prot
  SH3 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000002001 RatGTEx
  ENSRNOG00000061155 RatGTEx
SMART EFh UniProtKB/Swiss-Prot
  RhoGEF UniProtKB/Swiss-Prot
  SH3 UniProtKB/Swiss-Prot
  SM00027 UniProtKB/Swiss-Prot
  SM00233 UniProtKB/Swiss-Prot
  SM00239 UniProtKB/Swiss-Prot
Superfamily-SCOP PH domain-like UniProtKB/Swiss-Prot
  SSF47473 UniProtKB/Swiss-Prot
  SSF48065 UniProtKB/Swiss-Prot
  SSF49562 UniProtKB/Swiss-Prot
  SSF50044 UniProtKB/Swiss-Prot
TIGR TC220013
UniProt A0A8I5Y9J0 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6A7M7_RAT UniProtKB/TrEMBL
  A0A8I6ARZ8 ENTREZGENE, UniProtKB/TrEMBL
  A0A8L2QLK0 ENTREZGENE, UniProtKB/TrEMBL
  A0A8L2QM65 ENTREZGENE, UniProtKB/TrEMBL
  D3ZV52 ENTREZGENE
  F1M823 ENTREZGENE
  ITSN1_RAT UniProtKB/Swiss-Prot
  Q9WVE1 ENTREZGENE
  Q9WVE9 ENTREZGENE
UniProt Secondary D3ZV52 UniProtKB/Swiss-Prot
  F1M823 UniProtKB/Swiss-Prot
  Q9WVE1 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Itsn1  intersectin 1  LOC100911851  intersectin-1-like  Data merged from RGD:6490732 737654 PROVISIONAL
2015-11-19 Itsn1  intersectin 1  Itsn1  intersectin 1 (SH3 domain protein)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2012-07-05 LOC100911851  intersectin-1-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2008-11-17 Itsn1  intersectin 1 (SH3 domain protein)  Itsn1  intersectin 1 (SH3 domain protein 1A)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-05-19 Itsn1  intersectin 1 (SH3 domain protein 1A)  Itsn1  intersectin 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-30 Itsn1  intersectin 1  Itsn    Symbol updated 1299863 APPROVED
2002-06-10 Itsn  intersectin 1      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_domains has two EH domains,a central KLERQ domain and five SH3 domains 69862
gene_expression expressed abundantly in the brain 69862
gene_function an adaptor protein which participates in ther coupling of endocytic membrane traffic to exocytosis 69862