Inhbb (inhibin subunit beta B) - Rat Genome Database

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Gene: Inhbb (inhibin subunit beta B) Rattus norvegicus
Analyze
Symbol: Inhbb
Name: inhibin subunit beta B
RGD ID: 2913
Description: Predicted to enable cytokine activity and protein homodimerization activity. Involved in several processes, including cellular response to Thyroglobulin triiodothyronine; cellular response to alcohol; and gonad development. Located in extracellular space. Biomarker of congenital hypothyroidism. Orthologous to human INHBB (inhibin subunit beta B); PARTICIPATES IN transforming growth factor-beta superfamily mediated signaling pathway; INTERACTS WITH (+)-schisandrin B; 1,3,5-trinitro-1,3,5-triazinane; 17alpha-ethynylestradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: activin beta-B chain; activin betaB; inhibin beta B chain; inhibin beta B subunit; Inhibin beta subunit B; inhibin beta-B
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81333,083,671 - 33,089,373 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1333,083,671 - 33,089,609 (-)EnsemblGRCr8
mRatBN7.21330,530,860 - 30,536,566 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1330,530,860 - 30,537,832 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1333,113,093 - 33,118,804 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01334,400,910 - 34,406,621 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01331,675,032 - 31,680,728 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01335,436,532 - 35,442,222 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1335,436,532 - 35,442,222 (-)Ensemblrn6Rnor6.0
Rnor_5.01340,555,699 - 40,561,388 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41332,170,987 - 32,176,689 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1330,428,301 - 30,433,886 (-)NCBICelera
RGSC_v3.11332,178,994 - 32,179,566 (-)NCBI
Cytogenetic Map13q11NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane  (ISO)
1,1-dichloroethene  (ISO)
1,2-dimethylhydrazine  (ISO)
1,3,5-trinitro-1,3,5-triazinane  (EXP)
1-nitropyrene  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-D  (ISO)
2,4-dinitrotoluene  (EXP)
25-hydroxycholesterol  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,3',5-triiodo-L-thyronine  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
6-propyl-2-thiouracil  (EXP,ISO)
7,12-dimethyltetraphene  (ISO)
7,9-dihydro-1H-purine-2,6,8(3H)-trione  (ISO)
acetamide  (EXP)
acrylamide  (EXP,ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
alpha-Zearalanol  (EXP)
ammonium chloride  (EXP)
amphetamine  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
atrazine  (ISO)
Azoxymethane  (ISO)
benzo[a]pyrene  (ISO)
beta-lapachone  (ISO)
beta-naphthoflavone  (EXP,ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (EXP)
bisphenol F  (ISO)
butanal  (ISO)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP)
carbamazepine  (ISO)
carbon nanotube  (ISO)
cefaloridine  (EXP)
chlorpyrifos  (ISO)
choline  (ISO)
chromium(6+)  (EXP)
ciguatoxin CTX1B  (ISO)
cisplatin  (ISO)
cobalt dichloride  (EXP)
copper atom  (EXP)
copper(0)  (EXP)
copper(II) sulfate  (ISO)
coumestrol  (ISO)
Cuprizon  (EXP)
cyclosporin A  (ISO)
cypermethrin  (EXP,ISO)
DDE  (EXP)
dexamethasone  (ISO)
dextran sulfate  (ISO)
diarsenic trioxide  (ISO)
diarylheptanoid  (ISO)
dibenz[a,h]anthracene  (ISO)
dibutyl phthalate  (EXP)
diclofenac  (EXP,ISO)
Didecyldimethylammonium  (ISO)
diethyl maleate  (ISO)
diethylstilbestrol  (EXP,ISO)
diisononyl phthalate  (ISO)
dioxygen  (EXP,ISO)
Enterolactone  (ISO)
estriol  (ISO)
ethanol  (ISO)
folic acid  (ISO)
fonofos  (ISO)
genistein  (ISO)
glyphosate  (ISO)
graphite  (EXP)
Heptachlor epoxide  (ISO)
hydrogen peroxide  (ISO)
indometacin  (ISO)
isoprenaline  (ISO)
L-methionine  (ISO)
lead diacetate  (ISO)
leflunomide  (ISO)
lipopolysaccharide  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
menadione  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
nickel atom  (ISO)
Nonylphenol  (ISO)
obeticholic acid  (ISO)
oxaliplatin  (EXP)
paracetamol  (ISO)
parathion  (ISO)
perfluorononanoic acid  (EXP)
perfluorooctanoic acid  (EXP)
pirinixic acid  (ISO)
potassium chloride  (ISO)
potassium chromate  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
progesterone  (ISO)
quercetin  (ISO)
resveratrol  (ISO)
risperidone  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
streptozocin  (ISO)
sulforaphane  (ISO)
tamoxifen  (ISO)
terbufos  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (EXP,ISO)
tetrachloromethane  (EXP,ISO)
titanium dioxide  (ISO)
topotecan  (EXP)
tributylstannane  (EXP)
trichostatin A  (ISO)
trimellitic anhydride  (ISO)
triphenylstannane  (EXP,ISO)
urethane  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Regulation of inhibin/activin expression in rat early antral follicles. Andreone L, etal., Mol Cell Endocrinol. 2009 Oct 15;309(1-2):48-54. doi: 10.1016/j.mce.2009.05.003. Epub 2009 May 21.
2. Developmental expression of testis messenger ribonucleic acids in the rat following propylthiouracil-induced neonatal hypothyroidism. Bunick D, etal., Biol Reprod. 1994 Oct;51(4):706-13.
3. Triiodothyronine inhibits proliferation and stimulates differentiation of cultured neonatal Sertoli cells: possible mechanism for increased adult testis weight and sperm production induced by neonatal goitrogen treatment. Cooke PS, etal., Biol Reprod. 1994 Nov;51(5):1000-5.
4. [Study on the mechanism of di-2-ethylhexyl phthalate and cypermethrin inducing gonadal dysgenesis in the prepubertal male rats]. Gao L, etal., Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi. 2014 Mar;32(3):195-201.
5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
7. Expression of inhibin beta A and beta B, follistatin and activin-A receptor messenger ribonucleic acids in the rat seminiferous epithelium. Kaipia A, etal., Endocrinology. 1992 Dec;131(6):2703-10.
8. Sex difference in the action of activin-A on cell proliferation of differentiating rat gonad. Kaipia A, etal., Endocrinology. 1994 May;134(5):2165-70.
9. Regulation of inhibin beta B-subunit mRNA expression in rat Sertoli cells: consequences for the production of bioactive and immunoreactive inhibin. Klaij IA, etal., Mol Cell Endocrinol. 1992 Jun;85(3):237-46.
10. Gene expression profile in rat renal isografts from brain dead donors. Kusaka M, etal., Transplant Proc. 2005 Jan-Feb;37(1):364-6.
11. Weaning and the developmental changes in follicle-stimulating hormone, pituitary adenylate cyclase-activating polypeptide, and inhibin B in the male rat. Moore JP Jr and Winters SJ, Biol Reprod. 2008 Apr;78(4):752-60. Epub 2007 Dec 26.
12. Transcriptional regulation of inhibin beta B messenger ribonucleic acid levels in TM.4 or primary rat Sertoli cells by 8-bromo-cyclic adenosine monophosphate. Najmabadi H, etal., Mol Endocrinol. 1993 Apr;7(4):561-9.
13. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
14. Reciprocal regulation of activin A and inhibin B by interleukin-1 (IL-1) and follicle-stimulating hormone (FSH) in rat Sertoli cells in vitro. Okuma Y, etal., J Endocrinol. 2005 Apr;185(1):99-110.
15. Activin inhibition limits early innate immune response in rat kidney allografts-a pilot study. Palin NK, etal., Transpl Int. 2017 Jan;30(1):96-107. doi: 10.1111/tri.12876. Epub 2016 Nov 23.
16. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
17. GOA pipeline RGD automated data pipeline
18. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
19. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
20. Immunostainable inhibin subunits are in multiple types of testicular cells. Shaha C, etal., Endocrinology. 1989 Oct;125(4):1941-50.
21. Systemic blockade of ACVR2B ligands attenuates muscle wasting in ischemic heart failure without compromising cardiac function. Szabó Z, etal., FASEB J. 2020 Aug;34(8):9911-9924. doi: 10.1096/fj.201903074RR. Epub 2020 May 19.
22. Increasing blunting of inhibin responses to dynamic ovarian challenge is associated with reproductive aging in the rat. Yeh J and Kim B, Reprod Sci. 2007 Jan;14(1):10-9.
Additional References at PubMed
PMID:2484214   PMID:2575216   PMID:2628729   PMID:3122219   PMID:8033818   PMID:8133077   PMID:10320815   PMID:12419948   PMID:12729472   PMID:14561646   PMID:15070852   PMID:16601134  
PMID:16650820   PMID:17344471   PMID:17609433   PMID:18480258   PMID:19491194   PMID:19524137   PMID:19877505   PMID:20454446   PMID:21033444   PMID:21256182   PMID:24006456   PMID:27620967  
PMID:27693126   PMID:27922109  


Genomics

Comparative Map Data
Inhbb
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81333,083,671 - 33,089,373 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1333,083,671 - 33,089,609 (-)EnsemblGRCr8
mRatBN7.21330,530,860 - 30,536,566 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1330,530,860 - 30,537,832 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1333,113,093 - 33,118,804 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01334,400,910 - 34,406,621 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01331,675,032 - 31,680,728 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01335,436,532 - 35,442,222 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1335,436,532 - 35,442,222 (-)Ensemblrn6Rnor6.0
Rnor_5.01340,555,699 - 40,561,388 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41332,170,987 - 32,176,689 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1330,428,301 - 30,433,886 (-)NCBICelera
RGSC_v3.11332,178,994 - 32,179,566 (-)NCBI
Cytogenetic Map13q11NCBI
INHBB
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382120,346,136 - 120,351,803 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2120,346,136 - 120,351,803 (+)Ensemblhg38GRCh38
GRCh372121,103,712 - 121,109,379 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362120,820,189 - 120,825,853 (+)NCBIBuild 36Build 36hg18NCBI36
Build 342120,819,228 - 120,825,204NCBI
Celera2114,430,578 - 114,436,242 (+)NCBICelera
Cytogenetic Map2q14.2NCBI
HuRef2113,427,651 - 113,433,082 (+)NCBIHuRef
CHM1_12121,108,004 - 121,113,654 (+)NCBICHM1_1
T2T-CHM13v2.02120,780,882 - 120,786,549 (+)NCBIT2T-CHM13v2.0
Inhbb
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391119,343,193 - 119,349,978 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1119,343,195 - 119,349,978 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381119,415,463 - 119,422,248 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1119,415,465 - 119,422,248 (-)Ensemblmm10GRCm38
MGSCv371121,312,042 - 121,318,825 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361121,243,011 - 121,249,794 (-)NCBIMGSCv36mm8
Celera1122,074,716 - 122,081,040 (-)NCBICelera
Cytogenetic Map1E2.3NCBI
cM Map152.29NCBI
Inhbb
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554599,482,873 - 9,488,489 (-)Ensembl
ChiLan1.0NW_0049554599,482,998 - 9,488,489 (-)NCBIChiLan1.0ChiLan1.0
INHBB
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21322,348,480 - 22,354,168 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12B22,363,449 - 22,369,137 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B7,278,944 - 7,284,632 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B120,857,849 - 120,860,564 (+)NCBIPanPan1.1PanPan1.1panPan2
INHBB
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11929,765,697 - 29,768,485 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1929,767,682 - 29,768,077 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1930,022,868 - 30,028,528 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01931,138,047 - 31,143,715 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1931,140,035 - 31,144,819 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11929,828,236 - 29,833,891 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01929,997,586 - 30,003,232 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01931,183,308 - 31,188,970 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Inhbb
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530391,426,259 - 91,431,684 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493646950,186,036 - 50,191,461 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493646950,186,036 - 50,191,455 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
INHBB
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1530,999,520 - 31,004,405 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11530,999,994 - 31,004,405 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
INHBB
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1109,943,015 - 9,948,721 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366606112,740,168 - 12,745,889 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Inhbb
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473224,754,618 - 24,755,995 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462473224,754,601 - 24,755,890 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Inhbb
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11011,996,019 - 12,001,651 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Inhbb
37 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:187
Count of miRNA genes:143
Interacting mature miRNAs:153
Transcripts:ENSRNOT00000075142
Prediction methods:Miranda
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2317027Aia22Adjuvant induced arthritis QTL 222.29joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)13134785618Rat
9589141Insul28Insulin level QTL 2810.820.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)131186625456866254Rat
2317034Aia9Adjuvant induced arthritis QTL 94.62joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)131228551734884386Rat
61391Bp5Blood pressure QTL 55.6arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)132485392569853925Rat
1300163Cardf1Cardiac cell morphology QTL 14.18aorta morphology trait (VT:0000272)artery lesion measurement (CMO:0000975)131244842147969993Rat
2317040Aia21Adjuvant induced arthritis QTL 212.75joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)131238432057384320Rat
631645Bp121Blood pressure QTL 1213.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)131746828262468282Rat
2303030Bp327Blood pressure QTL 327arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)13143736554Rat
2317046Aia8Adjuvant induced arthritis QTL 83.9700000286102295joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)131238432057384320Rat
619615Bp80Blood pressure QTL 800.0354arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)13742179187286911Rat
2317044Aia23Adjuvant induced arthritis QTL 232.3joint integrity trait (VT:0010548)ankle joint diameter (CMO:0002148)131228551734884386Rat
61339Bp24Blood pressure QTL 240.05arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)13600200847359539Rat
1331784Bp222Blood pressure QTL 2222.944arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)132433543255601132Rat
1581573Uae36Urinary albumin excretion QTL 36urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)13600200888706694Rat
2302275Gluco37Glucose level QTL 373.8blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)131244842148744906Rat
7207885Glom27Glomerulus QTL 273.9kidney glomerulus integrity trait (VT:0010546)kidney crescentic glomeruli count to kidney normal glomeruli count ratio (CMO:0002139)1321120177109350286Rat
1558644Cm45Cardiac mass QTL 453.60.002heart mass (VT:0007028)heart wet weight (CMO:0000069)132624480871244808Rat
1354621Rf47Renal function QTL 473.7kidney renin amount (VT:0010559)kidney renin level (CMO:0002166)1311081740103588154Rat
1581554Pur11Proteinuria QTL 11urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)13600200888706694Rat
12879471Bp398Blood pressure QTL 398arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)13308875548088755Rat
631672Iddm12Insulin dependent diabetes mellitus QTL 122.20.0032blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)13600200837088115Rat
6893338Cm76Cardiac mass QTL 7600.99heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)132624480871244808Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)131103588154Rat
9589164Gluco66Glucose level QTL 666.670.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)131771133662711336Rat
738036Lnnr4Liver neoplastic nodule remodeling QTL 43.64liver integrity trait (VT:0010547)liver remodeling tumorous lesion number (CMO:0001461)13134785618Rat
7411662Foco29Food consumption QTL 2920.80.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)131186625456866254Rat

Markers in Region
D13Mgh16  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81333,084,788 - 33,084,932 (+)Marker Load Pipeline
mRatBN7.21330,531,977 - 30,532,123 (+)MAPPERmRatBN7.2
Rnor_6.01335,437,650 - 35,437,793NCBIRnor6.0
Rnor_5.01340,556,817 - 40,556,960UniSTSRnor5.0
RGSC_v3.41332,172,105 - 32,172,248UniSTSRGSC3.4
RGSC_v3.41332,172,104 - 32,172,248RGDRGSC3.4
Celera1330,429,419 - 30,429,562UniSTS
RGSC_v3.11332,174,928 - 32,175,072RGD
Cytogenetic Map13q11UniSTS
PMC155220P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21330,532,777 - 30,533,053 (+)MAPPERmRatBN7.2
Rnor_6.01335,438,448 - 35,438,723NCBIRnor6.0
Rnor_5.01340,557,615 - 40,557,890UniSTSRnor5.0
RGSC_v3.41332,172,903 - 32,173,178UniSTSRGSC3.4
Celera1330,430,217 - 30,430,492UniSTS
Cytogenetic Map13q11UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 65 146 88 87 56 42 56 6 300 140 11 122 80 92 31 14 14

Sequence


Ensembl Acc Id: ENSRNOT00000086350   ⟹   ENSRNOP00000071390
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1333,083,671 - 33,089,609 (-)Ensembl
mRatBN7.2 Ensembl1330,530,860 - 30,537,832 (-)Ensembl
Rnor_6.0 Ensembl1335,436,532 - 35,442,222 (-)Ensembl
RefSeq Acc Id: NM_080771   ⟹   NP_542949
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81333,083,671 - 33,089,373 (-)NCBI
mRatBN7.21330,530,860 - 30,536,566 (-)NCBI
Rnor_6.01335,436,532 - 35,442,222 (-)NCBI
Rnor_5.01340,555,699 - 40,561,388 (-)NCBI
RGSC_v3.41332,170,987 - 32,176,689 (-)RGD
Celera1330,428,301 - 30,433,886 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_542949 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA41438 (Get FASTA)   NCBI Sequence Viewer  
  AAM46787 (Get FASTA)   NCBI Sequence Viewer  
  EDL87910 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000071390
  ENSRNOP00000071390.2
GenBank Protein P17491 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_542949   ⟸   NM_080771
- Peptide Label: precursor
- UniProtKB: Q8K471 (UniProtKB/Swiss-Prot),   P17491 (UniProtKB/Swiss-Prot),   A0A0G2K0C6 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000071390   ⟸   ENSRNOT00000086350
Protein Domains
TGF-beta family profile

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P17491-F1-model_v2 AlphaFold P17491 1-411 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2913 AgrOrtholog
BioCyc Gene G2FUF-18524 BioCyc
Ensembl Genes ENSRNOG00000060237 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000086350 ENTREZGENE
  ENSRNOT00000086350.2 UniProtKB/Swiss-Prot
Gene3D-CATH 2.10.90.10 UniProtKB/Swiss-Prot
  2.60.120.970 UniProtKB/Swiss-Prot
InterPro Cystine-knot_cytokine UniProtKB/Swiss-Prot
  Inhibin_betaB UniProtKB/Swiss-Prot
  TGF-b_C UniProtKB/Swiss-Prot
  TGF-b_propeptide UniProtKB/Swiss-Prot
  TGF-beta-rel UniProtKB/Swiss-Prot
  TGFb_CS UniProtKB/Swiss-Prot
KEGG Report rno:25196 UniProtKB/Swiss-Prot
NCBI Gene 25196 ENTREZGENE
PANTHER PTHR11848 UniProtKB/Swiss-Prot
  PTHR11848:SF29 UniProtKB/Swiss-Prot
Pfam TGF_beta UniProtKB/Swiss-Prot
  TGFb_propeptide UniProtKB/Swiss-Prot
PhenoGen Inhbb PhenoGen
PRINTS INHIBINBB UniProtKB/Swiss-Prot
PROSITE TGF_BETA_1 UniProtKB/Swiss-Prot
  TGF_BETA_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000060237 RatGTEx
SMART TGFB UniProtKB/Swiss-Prot
Superfamily-SCOP SSF57501 UniProtKB/Swiss-Prot
UniProt A0A0G2K0C6 ENTREZGENE, UniProtKB/TrEMBL
  A6K7W5_RAT UniProtKB/TrEMBL
  INHBB_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q8K471 ENTREZGENE
UniProt Secondary Q8K471 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2018-05-25 Inhbb  inhibin subunit beta B  Inhbb  inhibin beta B subunit  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2016-06-01 Inhbb  inhibin beta B subunit  Inhbb  inhibin beta-B  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Inhbb  Inhibin beta subunit B      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_transcript promoter region contains several binding sites for transcription factor Spl 728954