Ifrd1 (interferon-related developmental regulator 1) - Rat Genome Database

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Gene: Ifrd1 (interferon-related developmental regulator 1) Rattus norvegicus
Analyze
Symbol: Ifrd1
Name: interferon-related developmental regulator 1
RGD ID: 2867
Description: Enables RNA polymerase II-specific DNA-binding transcription factor binding activity. Involved in glial cell proliferation and neuroblast proliferation. Acts upstream of or within positive regulation of DNA-binding transcription factor activity and positive regulation of transcription by RNA polymerase II. Predicted to be located in sarcoplasm. Predicted to be active in nucleus. Orthologous to human IFRD1 (interferon related developmental regulator 1); INTERACTS WITH (+)-schisandrin B; 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: IRPR; LOC102551830; MGC93482; nerve growth factor-inducible protein PC4; Pc4; uncharacterized LOC102551830
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8662,996,560 - 63,044,996 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl662,996,562 - 63,016,131 (-)EnsemblGRCr8
mRatBN7.2657,269,395 - 57,317,833 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl657,269,384 - 57,288,990 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx657,548,278 - 57,567,788 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0657,863,225 - 57,882,735 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0657,338,750 - 57,358,251 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0660,132,025 - 60,151,354 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl660,132,024 - 60,151,420 (-)Ensemblrn6Rnor6.0
Rnor_5.0669,720,077 - 69,739,406 (-)NCBIRnor_5.0Rnor_5.0rn5
Celera656,310,925 - 56,330,428 (-)NCBICelera
Cytogenetic Map6q21NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(S)-amphetamine  (ISO)
1,2-dimethylhydrazine  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
1-naphthyl isothiocyanate  (EXP)
1-nitropyrene  (ISO)
14-Deoxy-11,12-didehydroandrographolide  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (EXP,ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3-dimethoxynaphthalene-1,4-dione  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,4-dinitrotoluene  (EXP)
2-butoxyethanol  (ISO)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-(ethoxymethylene)-2-phenyloxazol-5-one  (ISO)
6-propyl-2-thiouracil  (EXP)
acrolein  (ISO)
afimoxifene  (ISO)
aflatoxin B1  (EXP,ISO)
alpha-pinene  (ISO)
amphetamine  (EXP)
ampicillin  (ISO)
antimony(0)  (ISO)
antimycin A  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
benzene  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
beta-lapachone  (ISO)
bilirubin IXalpha  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
brequinar  (ISO)
bromobenzene  (EXP)
butanal  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
chenodeoxycholic acid  (ISO)
chloroprene  (ISO)
choline  (ISO)
ciguatoxin CTX1B  (ISO)
clofibrate  (ISO)
clofibric acid  (EXP)
cobalt dichloride  (EXP,ISO)
cocaine  (EXP)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) chloride  (ISO)
copper(II) sulfate  (ISO)
crocidolite asbestos  (ISO)
cyclophosphamide  (ISO)
cyclosporin A  (ISO)
cylindrospermopsin  (ISO)
DDE  (ISO)
deguelin  (ISO)
deoxycholic acid  (ISO)
diarsenic trioxide  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (EXP,ISO)
diclofenac  (ISO)
dicrotophos  (ISO)
diethyl malate  (ISO)
diethyl maleate  (ISO)
dioxygen  (EXP,ISO)
dipotassium bis[mu-tartrato(4-)]diantimonate(2-) trihydrate  (ISO)
diquat  (ISO)
disodium selenite  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
elesclomol  (ISO)
endosulfan  (EXP)
enzyme inhibitor  (ISO)
epoxiconazole  (ISO)
ethanol  (ISO)
ethyl methanesulfonate  (ISO)
fenarimol  (EXP)
fenpyroximate  (ISO)
fluoranthene  (ISO)
flusilazole  (EXP)
flutamide  (EXP)
folic acid  (ISO)
formaldehyde  (ISO)
fulvestrant  (ISO)
gentamycin  (EXP)
gliotoxin  (EXP)
glycochenodeoxycholic acid  (ISO)
glycocholic acid  (ISO)
glycodeoxycholic acid  (ISO)
graphite  (EXP)
hydralazine  (ISO)
hydrogen peroxide  (ISO)
hydroquinone  (ISO)
indometacin  (EXP)
inulin  (ISO)
isoprenaline  (ISO)
isotretinoin  (ISO)
L-methionine  (ISO)
lead diacetate  (EXP)
lipopolysaccharide  (EXP)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
mercury atom  (ISO)
mercury dibromide  (ISO)
mercury dichloride  (EXP)
mercury(0)  (ISO)
metacetamol  (ISO)
methapyrilene  (EXP)
methyl methanesulfonate  (ISO)
methylisothiazolinone  (ISO)
methylmercury chloride  (ISO)
methylparaben  (ISO)
mitomycin C  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
N-acetyl-L-cysteine  (ISO)
N-methyl-4-phenylpyridinium  (EXP,ISO)
N-methyl-N'-nitro-N-nitrosoguanidine  (ISO)
N-methyl-N-nitrosourea  (ISO)
N-nitrosodimethylamine  (EXP)
N1'-[2-[[5-[(dimethylamino)methyl]-2-furanyl]methylthio]ethyl]-N1-methyl-2-nitroethene-1,1-diamine  (EXP)
nefazodone  (EXP)
nickel dichloride  (EXP)
nickel sulfate  (ISO)
nimesulide  (EXP)
ochratoxin A  (ISO)
okadaic acid  (ISO)
ozone  (EXP,ISO)
p-chloromercuribenzoic acid  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP,ISO)
phenobarbital  (EXP,ISO)
phenylmercury acetate  (ISO)
phorone  (EXP)
picoxystrobin  (ISO)
piperonyl butoxide  (EXP)
pirinixic acid  (EXP,ISO)
progesterone  (ISO)
propiconazole  (EXP,ISO)
pyrimidifen  (ISO)
quercetin  (ISO)
raloxifene  (ISO)
ranitidine  (EXP)
resveratrol  (ISO)
rotenone  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
sarin  (ISO)
SB 431542  (ISO)
sevoflurane  (EXP)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (EXP)
Soman  (EXP)
sulindac sulfide  (ISO)
T-2 toxin  (EXP)
tamoxifen  (ISO)
tetrachloromethane  (EXP,ISO)
thapsigargin  (ISO)
thifluzamide  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
Tributyltin oxide  (EXP)
trichloroethene  (EXP,ISO)
triphenyl phosphate  (ISO)
troglitazone  (ISO)
trovafloxacin  (EXP,ISO)
tunicamycin  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vincristine  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IEA,ISO)
nucleus  (IBA,IEA,ISO)
plasma membrane  (IEA)

References

References - curated
# Reference Title Reference Citation
1. Cloning of the human interferon-related developmental regulator (IFRD1) gene coding for the PC4 protein, a member of a novel family of developmentally regulated genes. Buanne P, etal., Genomics 1998 Jul 15;51(2):233-42.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. Inhibition of differentiation in myoblasts deprived of the interferon-related protein PC4. Guardavaccaro D, etal., Cell Growth Differ 1995 Feb;6(2):159-69.
5. Nerve growth factor regulates the subcellular localization of the nerve growth factor-inducible protein PC4 in PC12 cells. Guardavaccaro D, etal., J Neurosci Res 1994 Apr 1;37(5):660-74.
6. Expression of the PC4 gene in the developing rat nervous system. Iacopetti P, etal., Brain Res 1996 Jan 29;707(2):293-7.
7. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
8. PC4 coactivates MyoD by relieving the histone deacetylase 4-mediated inhibition of myocyte enhancer factor 2C. Micheli L, etal., Mol Cell Biol. 2005 Mar;25(6):2242-59.
9. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
10. GOA pipeline RGD automated data pipeline
11. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
12. Localization of 54 rat genes, and definition of new synteny groups conserved in the human and the rat. Szpirer C, etal., Mamm Genome 2000 Sep;11(9):729-35
13. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
14. Early gene regulation by nerve growth factor in PC12 cells: induction of an interferon-related gene. Tirone F and Shooter EM, Proc Natl Acad Sci U S A 1989 Mar;86(6):2088-92.
Additional References at PubMed
PMID:12477932   PMID:12691737   PMID:15060170   PMID:18052984   PMID:27358163  


Genomics

Comparative Map Data
Ifrd1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8662,996,560 - 63,044,996 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl662,996,562 - 63,016,131 (-)EnsemblGRCr8
mRatBN7.2657,269,395 - 57,317,833 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl657,269,384 - 57,288,990 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx657,548,278 - 57,567,788 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0657,863,225 - 57,882,735 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0657,338,750 - 57,358,251 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0660,132,025 - 60,151,354 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl660,132,024 - 60,151,420 (-)Ensemblrn6Rnor6.0
Rnor_5.0669,720,077 - 69,739,406 (-)NCBIRnor_5.0Rnor_5.0rn5
Celera656,310,925 - 56,330,428 (-)NCBICelera
Cytogenetic Map6q21NCBI
IFRD1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh387112,423,174 - 112,477,203 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl7112,422,887 - 112,481,017 (+)Ensemblhg38GRCh38
GRCh377112,063,229 - 112,117,258 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 367111,850,462 - 111,903,483 (+)NCBIBuild 36Build 36hg18NCBI36
Build 347111,684,465 - 111,710,195NCBI
Celera7106,875,197 - 106,928,212 (+)NCBICelera
Cytogenetic Map7q31.1NCBI
HuRef7106,430,932 - 106,484,922 (+)NCBIHuRef
CHM1_17111,997,329 - 112,051,377 (+)NCBICHM1_1
T2T-CHM13v2.07113,741,458 - 113,795,506 (+)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v27111,431,426 - 111,485,763 (+)NCBI
Ifrd1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391240,253,128 - 40,273,184 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1240,251,566 - 40,298,503 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381240,203,129 - 40,223,189 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1240,201,567 - 40,248,504 (-)Ensemblmm10GRCm38
MGSCv371240,929,716 - 40,949,776 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361240,713,553 - 40,733,587 (-)NCBIMGSCv36mm8
Celera1241,631,260 - 41,651,320 (-)NCBICelera
Cytogenetic Map12B1NCBI
cM Map1218.06NCBI
Ifrd1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541016,199,626 - 16,224,693 (+)Ensembl
ChiLan1.0NW_00495541016,176,431 - 16,222,006 (+)NCBIChiLan1.0ChiLan1.0
IFRD1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v26149,277,375 - 149,303,117 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan171,287,871 - 1,313,365 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v07104,412,763 - 104,438,490 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.17117,115,187 - 117,141,887 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl7117,115,187 - 117,141,887 (+)EnsemblpanPan2panpan1.1
IFRD1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11452,053,423 - 52,078,419 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1452,053,434 - 52,092,365 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1451,507,209 - 51,532,192 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01452,099,273 - 52,124,260 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1452,099,290 - 52,124,260 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11452,117,716 - 52,142,462 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01451,797,409 - 51,822,401 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01452,173,709 - 52,198,482 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Ifrd1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440511871,793,649 - 71,813,100 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936795573,581 - 594,278 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936795573,740 - 594,316 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
IFRD1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1833,193,426 - 33,248,297 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11833,198,002 - 33,248,912 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21835,914,259 - 35,964,925 (-)NCBISscrofa10.2Sscrofa10.2susScr3
IFRD1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12181,266,685 - 81,292,434 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2181,266,667 - 81,294,419 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604222,522,231 - 22,549,018 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ifrd1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473917,442,191 - 17,466,909 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462473917,442,191 - 17,492,191 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Ifrd1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1753,429,003 - 53,447,099 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Ifrd1
360 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:225
Count of miRNA genes:154
Interacting mature miRNAs:175
Transcripts:ENSRNOT00000073910
Prediction methods:Microtar, Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
9590290Uminl2Urine mineral level QTL 23.960.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)64451097489510974Rat
634318Bw118Body weight QTL 1183.55abdominal fat pad mass (VT:1000711)abdominal fat pad weight (CMO:0000088)63902865963457441Rat
4889933Bss88Bone structure and strength QTL 883.8tibia size trait (VT:0100001)tibia total bone volume (CMO:0001724)65368492198684921Rat
10401812Kidm54Kidney mass QTL 54kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)62009763565097635Rat
634307Bp141Blood pressure QTL 1414arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)64095756485957564Rat
1331743Uae28Urinary albumin excretion QTL 284.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)64515378690153786Rat
8552910Pigfal5Plasma insulin-like growth factor 1 level QTL 54.3blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)62265388967653889Rat
10401800Kidm49Kidney mass QTL 49kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)62009763565097635Rat
5684992Bmd83Bone mineral density QTL 824.8tibia mineral mass (VT:1000283)bone mineral content (CMO:0001554)65368492198684921Rat
1331779Rf38Renal function QTL 382.876kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)63118500276185002Rat
737827Hcar11Hepatocarcinoma resistance QTL 114.4liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)646050607116278722Rat
724513Uae14Urinary albumin excretion QTL 146.5urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)64604735391047353Rat
2293839Kiddil2Kidney dilation QTL 24.8kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)62661831486868070Rat
1576309Emca7Estrogen-induced mammary cancer QTL 74mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)620859430113082285Rat
9590140Scort4Serum corticosterone level QTL 414.490.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)64451097489510974Rat
2301964Bp323Blood pressure QTL 3234.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)6186868070Rat
9590306Scort18Serum corticosterone level QTL 182.880.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)64451097489510974Rat
1578665Bss16Bone structure and strength QTL 164.4femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)63332884178328841Rat
2293841Kiddil4Kidney dilation QTL 44.4kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)62661831486868070Rat
4889848Pur25Proteinuria QTL 25140.003urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)66303731995934232Rat
1641898Colcr4Colorectal carcinoma resistance QTL43.710.0007intestine integrity trait (VT:0010554)well differentiated malignant colorectal tumor surface area measurement (CMO:0002077)63093763275937632Rat
1578668Bmd14Bone mineral density QTL 143.8femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)63332884178328841Rat
6893340Cm77Cardiac mass QTL 770.260.57heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)63902865986867923Rat
5684963Bss99Bone structure and strength QTL 993.1tibia area (VT:1000281)tibia area measurement (CMO:0001382)65368492198684921Rat
70199Coreg1Compensatory renal growth QTL 111.8kidney mass (VT:0002707)compensatory renal growth score (CMO:0001894)61459947363457687Rat
1354664Slep2Serum leptin concentration QTL 24.49blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)62228825767288257Rat
1300143Rf14Renal function QTL 142.92renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)64016318385163183Rat

Markers in Region
RH130252  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2657,269,455 - 57,269,630 (+)MAPPERmRatBN7.2
Rnor_6.0660,132,079 - 60,132,253NCBIRnor6.0
Rnor_5.0669,720,131 - 69,720,305UniSTSRnor5.0
Celera656,310,979 - 56,311,153UniSTS
RH 3.4 Map6401.0UniSTS
Cytogenetic Map6q16UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000073910   ⟹   ENSRNOP00000067730
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl662,996,563 - 63,016,131 (-)Ensembl
mRatBN7.2 Ensembl657,269,384 - 57,288,990 (-)Ensembl
Rnor_6.0 Ensembl660,132,024 - 60,151,420 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000109955   ⟹   ENSRNOP00000089876
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl662,996,562 - 63,011,313 (-)Ensembl
mRatBN7.2 Ensembl657,269,384 - 57,284,154 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000114171   ⟹   ENSRNOP00000084296
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl657,269,384 - 57,288,981 (-)Ensembl
RefSeq Acc Id: NM_019242   ⟹   NP_062115
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8662,996,562 - 63,016,065 (-)NCBI
mRatBN7.2657,269,402 - 57,288,906 (-)NCBI
Rnor_6.0660,132,025 - 60,151,354 (-)NCBI
Rnor_5.0669,720,077 - 69,739,406 (-)NCBI
Celera656,310,925 - 56,330,428 (-)RGD
Sequence:
RefSeq Acc Id: XM_039111854   ⟹   XP_038967782
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8662,996,560 - 63,015,972 (-)NCBI
mRatBN7.2657,269,395 - 57,289,245 (-)NCBI
RefSeq Acc Id: XM_039111855   ⟹   XP_038967783
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8662,996,560 - 63,044,996 (-)NCBI
mRatBN7.2657,269,395 - 57,317,833 (-)NCBI
RefSeq Acc Id: XR_010052052
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8662,997,828 - 63,015,972 (-)NCBI
RefSeq Acc Id: NP_062115   ⟸   NM_019242
- UniProtKB: P20695 (UniProtKB/Swiss-Prot),   Q5XIV9 (UniProtKB/TrEMBL),   M0RDM5 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000067730   ⟸   ENSRNOT00000073910
RefSeq Acc Id: XP_038967783   ⟸   XM_039111855
- Peptide Label: isoform X2
- UniProtKB: A0A8I6ACL6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038967782   ⟸   XM_039111854
- Peptide Label: isoform X1
- UniProtKB: P20695 (UniProtKB/Swiss-Prot)
Ensembl Acc Id: ENSRNOP00000089876   ⟸   ENSRNOT00000109955
Ensembl Acc Id: ENSRNOP00000084296   ⟸   ENSRNOT00000114171
Protein Domains
Interferon-related developmental regulator C-   Interferon-related developmental regulator N-

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P20695-F1-model_v2 AlphaFold P20695 1-449 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13694571
Promoter ID:EPDNEW_R5096
Type:multiple initiation site
Name:Ifrd1_1
Description:interferon-related developmental regulator 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0660,151,438 - 60,151,498EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2867 AgrOrtholog
BioCyc Gene G2FUF-37743 BioCyc
Ensembl Genes ENSRNOG00000050997 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000073910 ENTREZGENE
  ENSRNOT00000109955 ENTREZGENE
Gene3D-CATH 1.25.10.10 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7193329 IMAGE-MGC_LOAD
InterPro ARM-like UniProtKB/Swiss-Prot
  ARM-type_fold UniProtKB/Swiss-Prot
  IFRD UniProtKB/Swiss-Prot
  Interferon-rel_develop_reg_C UniProtKB/Swiss-Prot
  Interferon-rel_develop_reg_N UniProtKB/Swiss-Prot
KEGG Report rno:29596 UniProtKB/Swiss-Prot
MGC_CLONE MGC:93482 IMAGE-MGC_LOAD
NCBI Gene 29596 ENTREZGENE
PANTHER INTERFERON-RELATED DEVELOPMENTAL REGULATOR 1 UniProtKB/Swiss-Prot
  PTHR12354 UniProtKB/Swiss-Prot
Pfam IFRD UniProtKB/Swiss-Prot
  IFRD_C UniProtKB/Swiss-Prot
PhenoGen Ifrd1 PhenoGen
RatGTEx ENSRNOG00000050997 RatGTEx
Superfamily-SCOP SSF48371 UniProtKB/Swiss-Prot
TIGR TC217577
UniProt A0A8I6ACL6 ENTREZGENE, UniProtKB/TrEMBL
  A6HBD4_RAT UniProtKB/TrEMBL
  IFRD1_RAT UniProtKB/Swiss-Prot
  M0RDM5 ENTREZGENE, UniProtKB/TrEMBL
  P20695 ENTREZGENE
  Q5XIV9 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Ifrd1  interferon-related developmental regulator 1  LOC102551830  uncharacterized LOC102551830  Data merged from RGD:7633421 737654 PROVISIONAL
2013-12-18 LOC102551830  uncharacterized LOC102551830      Symbol and Name status set to provisional 70820 PROVISIONAL
2002-06-10 Ifrd1  interferon-related developmental regulator 1      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_process may be involved in proliferation of neuronal and glial precursors 729202
gene_regulation expression induced by NGF 729202