Onecut1 (one cut homeobox 1) - Rat Genome Database

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Gene: Onecut1 (one cut homeobox 1) Rattus norvegicus
Analyze
Symbol: Onecut1
Name: one cut homeobox 1
RGD ID: 2811
Description: Enables DNA binding activity and DNA-binding transcription activator activity, RNA polymerase II-specific. Involved in glucose metabolic process and positive regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Orthologous to human ONECUT1 (one cut homeobox 1); PARTICIPATES IN maturity-onset diabetes of the young pathway; INTERACTS WITH 17beta-estradiol; 2,3,4,7,8-Pentachlorodibenzofuran; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: Hepatocyte nuclear factor 6; HNF-6; Hnf6; one cut domain family member 1; one cut domain, family member 1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8884,480,066 - 84,507,848 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl884,480,305 - 84,508,124 (+)EnsemblGRCr8
mRatBN7.2875,599,432 - 75,633,598 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl875,599,740 - 75,627,277 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx881,106,361 - 81,133,976 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0879,357,324 - 79,384,922 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0877,205,677 - 77,233,284 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0881,765,779 - 81,799,894 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl881,766,041 - 81,793,577 (+)Ensemblrn6Rnor6.0
Rnor_5.0881,384,757 - 81,418,580 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4879,644,305 - 79,672,772 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera875,394,297 - 75,421,855 (+)NCBICelera
RGSC_v3.1879,663,358 - 79,691,814 (+)NCBI
Cytogenetic Map8q24NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
1,2-dichloroethane  (ISO)
17beta-estradiol  (EXP,ISO)
2,3,4,7,8-Pentachlorodibenzofuran  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2-palmitoylglycerol  (ISO)
3-methylfuran  (EXP)
4,4'-sulfonyldiphenol  (ISO)
6-propyl-2-thiouracil  (EXP)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
alpha-hexachlorocyclohexane  (EXP)
amitrole  (EXP)
ammonium chloride  (EXP)
amosite asbestos  (ISO)
antimycin A  (ISO)
arsenite(3-)  (ISO)
aspartame  (ISO)
benzene  (EXP)
benzo[a]pyrene  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
Butylbenzyl phthalate  (ISO)
carbon nanotube  (ISO)
chlorohydrocarbon  (EXP)
choline  (ISO)
ciguatoxin CTX1B  (ISO)
cobalt dichloride  (EXP)
copper(II) sulfate  (ISO)
crocidolite asbestos  (ISO)
Cuprizon  (EXP)
cyclosporin A  (ISO)
decabromodiphenyl ether  (EXP)
deguelin  (ISO)
dexamethasone  (EXP)
dibenz[a,h]anthracene  (ISO)
endosulfan  (EXP)
epoxiconazole  (ISO)
folic acid  (ISO)
furan  (EXP)
gamma-hexachlorocyclohexane  (EXP)
GW 7647  (EXP)
hexadecanoic acid  (ISO)
L-methionine  (ISO)
lead diacetate  (ISO)
metformin  (EXP)
methamphetamine  (ISO)
methimazole  (EXP)
methoxychlor  (EXP)
methylmercury chloride  (EXP)
methylmercury(1+)  (EXP)
monosodium L-glutamate  (ISO)
N-nitrosodiethylamine  (EXP)
nefazodone  (EXP)
okadaic acid  (ISO)
ozone  (EXP,ISO)
paracetamol  (EXP,ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
phenobarbital  (EXP,ISO)
picoxystrobin  (ISO)
pirinixic acid  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
pyrimidifen  (ISO)
quercetin  (EXP)
rotenone  (EXP,ISO)
serpentine asbestos  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (EXP)
sulfadimethoxine  (EXP)
tebufenpyrad  (ISO)
tetrachloromethane  (ISO)
tetracycline  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
triadimefon  (EXP)
tributylstannane  (ISO)
trichloroethene  (EXP,ISO)
tris(2-butoxyethyl) phosphate  (ISO)
urethane  (ISO)
valproic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
nucleoplasm  (IEA,ISO)
nucleus  (IBA,IEA,ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Isoforms of hepatocyte nuclear factor-6 differ in DNA-binding properties, contain a bifunctional homeodomain, and define the new ONECUT class of homeodomain proteins. Lannoy VJ, etal., J Biol Chem 1998 May 29;273(22):13552-62.
4. Hepatocyte nuclear factor 6, a transcription factor that contains a novel type of homeodomain and a single cut domain. Lemaigre FP, etal., Proc Natl Acad Sci U S A 1996 Sep 3;93(18):9460-4.
5. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
6. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
7. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
9. Hepatocyte nuclear factor-4alpha interacts with other hepatocyte nuclear factors in regulating transthyretin gene expression. Wang Z and Burke PA, FEBS J. 2010 Oct;277(19):4066-75. doi: 10.1111/j.1742-4658.2010.07802.x. Epub 2010 Aug 23.
Additional References at PubMed
PMID:8887657   PMID:10825208   PMID:11944891   PMID:12874218   PMID:15548585   PMID:16103213   PMID:16472605   PMID:16912278   PMID:17223534   PMID:17261592   PMID:17400205   PMID:17936262  
PMID:22780989   PMID:25446530   PMID:33222081  


Genomics

Comparative Map Data
Onecut1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8884,480,066 - 84,507,848 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl884,480,305 - 84,508,124 (+)EnsemblGRCr8
mRatBN7.2875,599,432 - 75,633,598 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl875,599,740 - 75,627,277 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx881,106,361 - 81,133,976 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0879,357,324 - 79,384,922 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0877,205,677 - 77,233,284 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0881,765,779 - 81,799,894 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl881,766,041 - 81,793,577 (+)Ensemblrn6Rnor6.0
Rnor_5.0881,384,757 - 81,418,580 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4879,644,305 - 79,672,772 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera875,394,297 - 75,421,855 (+)NCBICelera
RGSC_v3.1879,663,358 - 79,691,814 (+)NCBI
Cytogenetic Map8q24NCBI
ONECUT1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381552,755,053 - 52,790,336 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1552,755,053 - 52,791,078 (-)Ensemblhg38GRCh38
GRCh371553,047,250 - 53,082,533 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361550,836,645 - 50,869,501 (-)NCBIBuild 36Build 36hg18NCBI36
Build 341550,836,644 - 50,869,501NCBI
Celera1529,944,311 - 29,977,184 (-)NCBICelera
Cytogenetic Map15q21.3NCBI
HuRef1529,879,668 - 29,912,665 (-)NCBIHuRef
CHM1_11553,167,071 - 53,200,155 (-)NCBICHM1_1
T2T-CHM13v2.01550,563,333 - 50,598,640 (-)NCBIT2T-CHM13v2.0
Onecut1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39974,769,203 - 74,796,930 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl974,769,203 - 74,799,063 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38974,861,921 - 74,889,648 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl974,861,921 - 74,891,781 (+)Ensemblmm10GRCm38
MGSCv37974,709,728 - 74,737,455 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36974,648,524 - 74,676,252 (+)NCBIMGSCv36mm8
Celera972,045,890 - 72,046,250 (+)NCBICelera
Cytogenetic Map9DNCBI
cM Map941.93NCBI
Onecut1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554092,181,346 - 2,207,888 (+)Ensembl
ChiLan1.0NW_0049554092,181,364 - 2,214,636 (+)NCBIChiLan1.0ChiLan1.0
ONECUT1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21641,982,502 - 42,023,294 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11546,162,843 - 46,203,617 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01531,694,830 - 31,727,644 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11550,017,606 - 50,053,058 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1550,016,010 - 50,053,062 (-)EnsemblpanPan2panpan1.1
ONECUT1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13018,384,533 - 18,425,940 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3018,387,130 - 18,425,497 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha3018,312,652 - 18,353,439 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.03018,533,528 - 18,574,309 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3018,535,494 - 18,574,636 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13018,451,424 - 18,492,204 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03018,570,831 - 18,609,718 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03018,674,572 - 18,715,403 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
LOC101960907
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864096,722,333 - 96,733,257 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647114,532,892 - 14,566,904 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493647114,532,888 - 14,581,258 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ONECUT1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1118,913,460 - 118,917,334 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11118,913,400 - 118,958,140 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21131,981,708 - 132,019,991 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ONECUT1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12630,609,392 - 30,645,996 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666048110,585,853 - 110,622,490 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Onecut1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247317,911,264 - 7,939,434 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247317,911,352 - 7,938,440 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Onecut1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1869,148,023 - 69,175,439 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Onecut1
119 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:172
Count of miRNA genes:63
Interacting mature miRNAs:81
Transcripts:ENSRNOT00000010738, ENSRNOT00000032280
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1298065Scl16Serum cholesterol level QTL 163.8blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)83975280384752803Rat
1554321Bmd3Bone mineral density QTL 37.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)849849908118871671Rat
9590292Uminl3Urine mineral level QTL 33.620.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)880768445125768445Rat
1578769Uae31Urinary albumin excretion QTL 313.30.001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)839106363103375781Rat
1298079Activ2Activity QTL 29.50.000001voluntary movement trait (VT:0003491)rearing measurement (CMO:0001515)85076395195763951Rat
70161Bp62Blood pressure QTL 622.90.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)85158969999045312Rat
1578765Klgr1Kidney lesion grade QTL 13.30.0001kidney morphology trait (VT:0002135)organ lesion measurement (CMO:0000677)839106363103375781Rat
61464Niddm11Non-insulin dependent diabetes mellitus QTL 113.10.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)84447792689477926Rat
4889938Bss89Bone structure and strength QTL 893.8tibia size trait (VT:0100001)tibia cortical bone volume (CMO:0001725)85899169791341052Rat
1578755Pur5Proteinuria QTL 53.30.0001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)839106258103375958Rat
2313088Bss75Bone structure and strength QTL 753.10.0001body length (VT:0001256)body length, nose to rump (CMO:0000079)83910625891341052Rat
631210Bw3Body weight QTL35.9mesenteric fat pad mass (VT:0010427)mesenteric fat pad weight to body weight ratio (CMO:0000654)861019838121662124Rat
8662823Vetf5Vascular elastic tissue fragility QTL 51.9artery integrity trait (VT:0010639)patent ductus arteriosus score (CMO:0002566)863404444108404444Rat
1358896Bp262Blood pressure QTL 2622.89arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)835464071107982864Rat
731182Uae24Urinary albumin excretion QTL 246.4urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)84754141992541419Rat
8694446Bw170Body weight QTL 17012.070.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)880768445125768445Rat
1331769Rf39Renal function QTL 393.871urine output (VT:0003620)timed urine volume (CMO:0000260)850763951107970527Rat
61358Bp39Blood pressure QTL 392arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)84444783789447837Rat
1358906Bp253Blood pressure QTL 25340.0004arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)84961020494610204Rat
10450865Bw175Body weight QTL 1754.1total fat pad mass (VT:0015008)adipose tissue molecular composition measurement (CMO:0000484)884192326129192326Rat
1358907Cm40Cardiac mass QTL 401.89heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)835464071107982864Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)855428333127966348Rat
2316950Scl66Serum cholesterol level QTL 664.1blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)839106363114525825Rat
1582254Kidm31Kidney mass QTL 313kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)84924517894245178Rat
724540Uae8Urinary albumin excretion QTL 85urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)839106258103375958Rat
10402857Bp380Blood pressure QTL 3800.95arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)862848139107848139Rat
1358892Kidm26Kidney mass QTL 263.69kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)835464071107982864Rat
1582243Bw66Body weight QTL 663.40.0048body mass (VT:0001259)body weight (CMO:0000012)84924517894245178Rat
5684973Bss100Bone structure and strength QTL 1004.7tibia area (VT:1000281)tibia area measurement (CMO:0001382)85899169791341052Rat
8694200Abfw4Abdominal fat weight QTL 49.070.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)880768445125768445Rat
61373Mcs4Mammary carcinoma susceptibility QTL 41.1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)84447504389475043Rat
2313057Bss76Bone structure and strength QTL 7630.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)83910625891341052Rat
12879878Bw183Body weight QTL 1830.001body mass (VT:0001259)body weight (CMO:0000012)862848139107848139Rat
1300177Cm2Cardiac mass QTL 23.65heart mass (VT:0007028)heart weight (CMO:0000017)863141536109261840Rat
1549909Stresp11Stress response QTL 116.830.0019stress-related behavior trait (VT:0010451)number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)882352698127352698Rat
1549908Neudeg1Neurodegradation QTL 15.50nervous system integrity trait (VT:0010566)logarithm of the ratio of the lesioned side motor neuron count to contralateral side motor neuron count (CMO:0001986)858337123103337123Rat
12879879Cm99Cardiac mass QTL 990.001heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)862848139107848139Rat
2313067Bss77Bone structure and strength QTL 773.10.0001tibia size trait (VT:0100001)tibia midshaft endosteal cross-sectional area (CMO:0001716)83910625891341052Rat
1331804Cm30Cardiac mass QTL 303.77443heart mass (VT:0007028)heart wet weight (CMO:0000069)862970527107970527Rat
12879880Cm100Cardiac mass QTL 1000.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)862848139107848139Rat
12879881Cm101Cardiac mass QTL 1010.001heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)862848139107848139Rat
12879882Am8Aortic mass QTL 80.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)862848139107848139Rat
12879883Kidm65Kidney mass QTL 650.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)862848139107848139Rat
71120Niddm21Non-insulin dependent diabetes mellitus QTL 213.73blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)866992095111992095Rat
1358912Bw51Body weight QTL 512.95body mass (VT:0001259)body weight (CMO:0000012)860248093105248093Rat
634332Pia18Pristane induced arthritis QTL 184joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)884192326132782436Rat
1300171Bp184Blood pressure QTL 1843.66arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)879394435132782436Rat
2313086Bss60Bone structure and strength QTL 604.10.0001tibia length (VT:0004357)tibia length (CMO:0000450)85899169791341052Rat
2293697Bmd39Bone mineral density QTL 39femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)862848139107848139Rat
1331837Bw23Body weight QTL 234.190.00007body mass (VT:0001259)body weight (CMO:0000012)855428416107963099Rat
1331838Niddm61Non-insulin dependent diabetes mellitus QTL 613.530.0004blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)862963099107963099Rat
631650Stl6Serum triglyceride level QTL 640.0019blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)870041301121080908Rat
1581557Eae16Experimental allergic encephalomyelitis QTL 163.8nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)868690349119799881Rat
2313046Bss78Bone structure and strength QTL 783.50.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)83910625891341052Rat
2301402Bp316Blood pressure QTL 3160.005arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)862848139107848139Rat
631664Hcar3Hepatocarcinoma resistance QTL 32.90.0005liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)862982864107982864Rat
8694392Bw161Body weight QTL 1618.060.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)880768445125768445Rat

Markers in Region
RH137454  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2875,626,767 - 75,626,981 (+)MAPPERmRatBN7.2
Rnor_6.0881,793,068 - 81,793,281NCBIRnor6.0
Rnor_5.0881,411,754 - 81,411,967UniSTSRnor5.0
RGSC_v3.4879,672,251 - 79,672,464UniSTSRGSC3.4
Celera875,421,334 - 75,421,547UniSTS
Cytogenetic Map8q24-q31UniSTS
PMC316377P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2875,600,549 - 75,600,844 (+)MAPPERmRatBN7.2
Rnor_6.0881,766,840 - 81,767,134NCBIRnor6.0
Rnor_5.0881,385,734 - 81,386,028UniSTSRnor5.0
RGSC_v3.4879,645,115 - 79,645,409UniSTSRGSC3.4
Celera875,395,107 - 75,395,401UniSTS
Cytogenetic Map8q24-q31UniSTS
PMC85812P3  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2875,600,669 - 75,601,038 (+)MAPPERmRatBN7.2
Rnor_6.0881,766,960 - 81,767,328NCBIRnor6.0
Rnor_5.0881,385,854 - 81,386,222UniSTSRnor5.0
RGSC_v3.4879,645,235 - 79,645,603UniSTSRGSC3.4
Celera875,395,227 - 75,395,595UniSTS
Cytogenetic Map8q24-q31UniSTS
UniSTS:462690  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2875,600,234 - 75,600,747 (+)MAPPERmRatBN7.2
Rnor_6.0881,766,525 - 81,767,037NCBIRnor6.0
Rnor_5.0881,385,419 - 81,385,931UniSTSRnor5.0
RGSC_v3.4879,644,800 - 79,645,312UniSTSRGSC3.4
Celera875,394,792 - 75,395,304UniSTS
Cytogenetic Map8q24-q31UniSTS
Onecut1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2875,626,381 - 75,626,476 (+)MAPPERmRatBN7.2
Rnor_6.0881,792,682 - 81,792,776NCBIRnor6.0
Rnor_5.0881,411,368 - 81,411,462UniSTSRnor5.0
RGSC_v3.4879,671,865 - 79,671,959UniSTSRGSC3.4
Celera875,420,948 - 75,421,042UniSTS
Cytogenetic Map8q24-q31UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
10 3 10 136 83 78 59 19 59 6 172 58 9 110 43 78 19 14 14

Sequence


Ensembl Acc Id: ENSRNOT00000032280   ⟹   ENSRNOP00000038480
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl884,480,305 - 84,507,836 (+)Ensembl
mRatBN7.2 Ensembl875,599,740 - 75,627,277 (+)Ensembl
Rnor_6.0 Ensembl881,766,041 - 81,793,577 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000101262   ⟹   ENSRNOP00000096278
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl884,480,343 - 84,508,124 (+)Ensembl
mRatBN7.2 Ensembl875,599,977 - 75,626,634 (+)Ensembl
RefSeq Acc Id: NM_022671   ⟹   NP_073162
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8884,480,305 - 84,507,848 (+)NCBI
mRatBN7.2875,599,740 - 75,627,289 (+)NCBI
Rnor_6.0881,766,030 - 81,793,589 (+)NCBI
Rnor_5.0881,384,757 - 81,418,580 (+)NCBI
RGSC_v3.4879,644,305 - 79,672,772 (+)RGD
Celera875,394,297 - 75,421,855 (+)RGD
Sequence:
RefSeq Acc Id: XM_006243404   ⟹   XP_006243466
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8884,480,066 - 84,507,757 (+)NCBI
mRatBN7.2875,599,432 - 75,633,598 (+)NCBI
Rnor_6.0881,765,779 - 81,799,894 (+)NCBI
Rnor_5.0881,384,757 - 81,418,580 (+)NCBI
Sequence:
RefSeq Acc Id: NP_073162   ⟸   NM_022671
- UniProtKB: P70512 (UniProtKB/Swiss-Prot),   O88755 (UniProtKB/Swiss-Prot),   G3V975 (UniProtKB/TrEMBL),   A6I1A4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006243466   ⟸   XM_006243404
- Peptide Label: isoform X1
- UniProtKB: P70512 (UniProtKB/Swiss-Prot),   O88755 (UniProtKB/Swiss-Prot),   A0A8I6APA2 (UniProtKB/TrEMBL),   A6I1A3 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000038480   ⟸   ENSRNOT00000032280
Ensembl Acc Id: ENSRNOP00000096278   ⟸   ENSRNOT00000101262
Protein Domains
CUT   Homeobox

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P70512-F1-model_v2 AlphaFold P70512 1-465 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2811 AgrOrtholog
BioCyc Gene G2FUF-29828 BioCyc
Ensembl Genes ENSRNOG00000008095 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000032280 ENTREZGENE
  ENSRNOT00000101262 ENTREZGENE
Gene3D-CATH 1.10.260.40 UniProtKB/Swiss-Prot
  Homeodomain-like UniProtKB/Swiss-Prot
InterPro CUT_dom UniProtKB/Swiss-Prot
  CUT_Homeobox UniProtKB/Swiss-Prot
  Homeobox-like_sf UniProtKB/Swiss-Prot
  Homeobox_dom UniProtKB/Swiss-Prot
  Lambda_DNA-bd_dom_sf UniProtKB/Swiss-Prot
KEGG Report rno:25231 UniProtKB/Swiss-Prot
NCBI Gene 25231 ENTREZGENE
PANTHER HEPATOCYTE NUCLEAR FACTOR 6 UniProtKB/Swiss-Prot
  TRANSCRIPTION FACTOR ONECUT UniProtKB/Swiss-Prot
Pfam CUT UniProtKB/Swiss-Prot
  Homeodomain UniProtKB/Swiss-Prot
PhenoGen Onecut1 PhenoGen
PROSITE CUT UniProtKB/Swiss-Prot
  HOMEOBOX_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000008095 RatGTEx
SMART CUT UniProtKB/Swiss-Prot
  HOX UniProtKB/Swiss-Prot
Superfamily-SCOP SSF46689 UniProtKB/Swiss-Prot
  SSF47413 UniProtKB/Swiss-Prot
UniProt A0A8I6APA2 ENTREZGENE, UniProtKB/TrEMBL
  A6I1A1_RAT UniProtKB/TrEMBL
  A6I1A2_RAT UniProtKB/TrEMBL
  A6I1A3 ENTREZGENE, UniProtKB/TrEMBL
  A6I1A4 ENTREZGENE, UniProtKB/TrEMBL
  G3V975 ENTREZGENE, UniProtKB/TrEMBL
  HNF6_RAT UniProtKB/Swiss-Prot
  O88755 ENTREZGENE
  P70512 ENTREZGENE
UniProt Secondary O88755 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-09-25 Onecut1  one cut homeobox 1  Onecut1  one cut domain, family member 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-11-06 Onecut1  one cut domain, family member 1  Hnf6  Hepatocyte nuclear factor 6  Symbol and Name updated 625702 APPROVED
2002-06-10 Hnf6  Hepatocyte nuclear factor 6      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in liver, brain, spleen, pancreas, and testis 729086
gene_function binds to DNA 729086