Hmgcs2 (3-hydroxy-3-methylglutaryl-CoA synthase 2) - Rat Genome Database

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Gene: Hmgcs2 (3-hydroxy-3-methylglutaryl-CoA synthase 2) Rattus norvegicus
Analyze
Symbol: Hmgcs2
Name: 3-hydroxy-3-methylglutaryl-CoA synthase 2
RGD ID: 2804
Description: Enables hydroxymethylglutaryl-CoA synthase activity. Involved in several processes, including cellular response to insulin stimulus; cellular response to lipopolysaccharide; and ketone body biosynthetic process. Located in mitochondrial matrix. Biomarker of extrahepatic cholestasis. Human ortholog(s) of this gene implicated in HMG-CoA synthase 2 deficiency. Orthologous to human HMGCS2 (3-hydroxy-3-methylglutaryl-CoA synthase 2); PARTICIPATES IN 3-hydroxy-3-methylglutaryl-CoA lyase deficiency pathway; 3-hydroxyisobutyric aciduria pathway; 3-methylcrotonyl CoA carboxylase 1 deficiency pathway; INTERACTS WITH (+)-schisandrin B; 1-benzylpiperazine; 17alpha-ethynylestradiol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: 3-hydroxy-3-methylglutary-Coenzyme A synthase; 3-hydroxy-3-methylglutary-Coenzyme A synthase 2; 3-hydroxy-3-methylglutaryl coenzyme A synthase; 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial); 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 2; 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 2 (mitochondrial); HMG-CoA synthase; Hmgcs1; hydroxymethylglutaryl-CoA synthase 2; hydroxymethylglutaryl-CoA synthase, mitochondrial; Mt3h3mg
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82188,564,348 - 188,590,872 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl2188,547,767 - 188,592,242 (+)EnsemblGRCr8
mRatBN7.22185,875,609 - 185,903,505 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2185,875,616 - 185,902,130 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx2193,524,494 - 193,551,482 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02191,333,168 - 191,359,836 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02186,157,074 - 186,184,065 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.02200,452,623 - 200,480,785 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2200,452,624 - 200,479,423 (+)Ensemblrn6Rnor6.0
Rnor_5.02219,928,546 - 219,956,233 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.42193,128,736 - 193,143,106 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera2178,363,353 - 178,390,245 (+)NCBICelera
RGSC_v3.12193,091,489 - 193,105,860 (+)NCBI
Cytogenetic Map2q34NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (ISO)
(+)-dexrazoxane  (ISO)
(+)-schisandrin B  (EXP)
1,2-dimethylhydrazine  (ISO)
1-benzylpiperazine  (EXP)
14-Deoxy-11,12-didehydroandrographolide  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2-butan-2-yl-4-[4-[4-[4-[[2-(2,4-dichlorophenyl)-2-(1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-1-piperazinyl]phenyl]-1,2,4-triazol-3-one  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,3',5-triiodo-L-thyronine  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3-chloropropane-1,2-diol  (EXP,ISO)
3-hydroxybutyric acid  (ISO)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
acrylamide  (EXP)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
Aroclor 1254  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
benzalkonium chloride  (ISO)
benzo[a]pyrene  (ISO)
Benzo[k]fluoranthene  (ISO)
bezafibrate  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bromobenzene  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
cafestol  (EXP)
calcium atom  (EXP)
calcium(0)  (EXP)
captan  (ISO)
carbon nanotube  (ISO)
carbonyl sulfide  (EXP)
carnosic acid  (ISO)
cefaloridine  (EXP)
cetrorelix  (ISO)
chenodeoxycholic acid  (ISO)
CHIR 99021  (ISO)
chlorpyrifos  (ISO)
ciglitazone  (ISO)
ciguatoxin CTX1B  (ISO)
ciprofibrate  (ISO)
cisplatin  (ISO)
clofibrate  (EXP,ISO)
Clofop  (ISO)
cobalt dichloride  (EXP)
copper atom  (EXP)
copper(0)  (EXP)
corticosterone  (EXP)
Cuprizon  (EXP)
cyclophosphamide  (EXP)
cyclosporin A  (ISO)
cytarabine  (ISO)
deoxycholic acid  (ISO)
desogestrel  (ISO)
dexamethasone  (EXP)
dichlorine  (EXP)
dichloroacetic acid  (ISO)
diclofenac  (ISO)
diethyl malate  (ISO)
diethyl phthalate  (EXP)
dimethyl sulfoxide  (ISO)
dimethylarsinic acid  (ISO)
dipentyl phthalate  (EXP)
diquat  (ISO)
diuron  (EXP)
dopamine  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP,ISO)
entinostat  (ISO)
ethanol  (EXP,ISO)
fenofibrate  (EXP,ISO)
fenoldopam  (EXP)
fipronil  (EXP,ISO)
flutamide  (EXP)
folic acid  (ISO)
folpet  (ISO)
fructose  (EXP)
fumonisin B1  (ISO)
furan  (EXP)
gadolinium trichloride  (EXP)
gemfibrozil  (EXP)
genistein  (EXP)
gentamycin  (EXP)
glafenine  (EXP)
glycochenodeoxycholic acid  (ISO)
glycocholic acid  (ISO)
glycodeoxycholic acid  (ISO)
glyphosate  (ISO)
GW 4064  (ISO)
GW 501516  (ISO)
GW 7647  (EXP,ISO)
Heptachlor epoxide  (ISO)
hydrazine  (ISO)
indometacin  (EXP,ISO)
iron atom  (EXP)
iron(0)  (EXP)
itraconazole  (ISO)
ketamine  (EXP)
ketoconazole  (ISO)
L-ascorbic acid  (ISO)
L-ascorbic acid 2-phosphate  (ISO)
lamivudine  (ISO)
lead diacetate  (ISO)
lithocholic acid  (ISO)
manganese atom  (EXP)
manganese(0)  (EXP)
manganese(II) chloride  (EXP)
menadione  (ISO)
Mesaconitine  (EXP)
methapyrilene  (EXP)
methidathion  (ISO)
methimazole  (EXP)
methotrexate  (EXP)
methylarsonic acid  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
morphine  (ISO)
Muraglitazar  (EXP)
N,N-diethyl-m-toluamide  (ISO)
N-nitrosodiethylamine  (EXP)
N-nitrosomorpholine  (EXP)
N-Nitrosopyrrolidine  (ISO)
nevirapine  (EXP)
nickel atom  (ISO)
nickel dichloride  (EXP)
nitrofen  (EXP)
O-methyleugenol  (ISO)
okadaic acid  (ISO)
oxybenzone  (EXP)
ozone  (EXP,ISO)
p-toluidine  (EXP)
paclitaxel  (EXP)
paracetamol  (EXP,ISO)
perfluorodecanoic acid  (ISO)
perfluorododecanoic acid  (ISO)
perfluoroheptanoic acid  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (EXP,ISO)
phenethyl caffeate  (EXP)
phenobarbital  (ISO)
phenylarsine oxide  (ISO)
PhIP  (EXP)
pirinixic acid  (EXP,ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
progesterone  (EXP)
propiconazole  (ISO)
prostaglandin F2alpha  (EXP)
pyrazinecarboxamide  (EXP)
pyrrolidine dithiocarbamate  (EXP)
quercetin  (EXP,ISO)
resveratrol  (ISO)
rotenone  (EXP)
SB 431542  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (EXP,ISO)
sodium dichromate  (EXP)
streptozocin  (EXP)
tacrolimus hydrate  (ISO)
tamoxifen  (ISO)
tartrazine  (ISO)
tebuconazole  (ISO)
Tesaglitazar  (EXP)
testosterone enanthate  (ISO)
Tetrachlorobisphenol A  (ISO)
tetrachloroethene  (ISO)
tetrachloromethane  (EXP,ISO)
tetracycline  (ISO)
tetrathiomolybdate(2-)  (EXP)
thallium atom  (EXP)
thallium sulfate  (EXP)
thiacloprid  (ISO)
thioacetamide  (EXP)
thiophanate-methyl  (ISO)
tributylstannane  (EXP)
trichloroethene  (EXP,ISO)
trimellitic anhydride  (ISO)
triptonide  (ISO)
troglitazone  (EXP,ISO)
urethane  (ISO)
ursodeoxycholic acid  (EXP)
valproic acid  (ISO)
vanadyl sulfate  (EXP)
XAV939  (ISO)
zidovudine  (ISO)
zinc atom  (EXP)
zinc sulfate  (ISO)
zinc(0)  (EXP)
ziram  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
mitochondrial matrix  (IDA)
mitochondrion  (IBA,IEA,ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. The effect of fasting/refeeding and insulin treatment on the expression of the regulatory genes of ketogenesis in intestine and liver of suckling rats. Arias G, etal., Arch Biochem Biophys. 1997 Apr 15;340(2):287-98.
2. The effect of dexamethasone treatment on the expression of the regulatory genes of ketogenesis in intestine and liver of suckling rats. Arias G, etal., Mol Cell Biochem. 1998 Jan;178(1-2):325-33.
3. The effect of etomoxir on the mRNA levels of enzymes involved in ketogenesis and cholesterogenesis in rat liver. Asins G, etal., Biochem Pharmacol. 1994 Apr 20;47(8):1373-9.
4. Methylation of the regulatory region of the mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase gene leads to its transcriptional inactivation. Ayte J, etal., Biochem J. 1993 Nov 1;295 ( Pt 3):807-12.
5. Rat mitochondrial and cytosolic 3-hydroxy-3-methylglutaryl-CoA synthases are encoded by two different genes. Ayte J, etal., Proc Natl Acad Sci U S A 1990 May;87(10):3874-8.
6. Effects of fatty acids and growth hormone on liver fatty acid binding protein and PPARalpha in rat liver. Carlsson L, etal., Am J Physiol Endocrinol Metab. 2001 Oct;281(4):E772-81.
7. Expression of mitochondrial HMGCoA synthase and glutaminase in the colonic mucosa is modulated by bacterial species. Cherbuy C, etal., Eur J Biochem. 2004 Jan;271(1):87-95.
8. The ketogenic diet; fatty acids, fatty acid-activated receptors and neurological disorders. Cullingford TE Prostaglandins Leukot Essent Fatty Acids. 2004 Mar;70(3):253-64.
9. Hormonal regulation of the mRNA encoding the ketogenic enzyme mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase in neonatal primary cultures of cortical astrocytes and meningeal fibroblasts. Cullingford TE, etal., J Neurochem. 1998 Nov;71(5):1804-12.
10. Chronic quercetin exposure affects fatty acid catabolism in rat lung. de Boer VC, etal., Cell Mol Life Sci. 2006 Dec;63(23):2847-58.
11. Dissimilar Properties of Vaccenic Versus Elaidic Acid in beta-Oxidation Activities and Gene Regulation in Rat Liver Cells. Du ZY, etal., Lipids. 2010 May 28.
12. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
13. The rat mitochondrial 3-hydroxy-3-methylglutaryl-coenzyme-A-synthase gene contains elements that mediate its multihormonal regulation and tissue specificity. Gil-Gomez G, etal., Eur J Biochem 1993 Apr 15;213(2):773-9.
14. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
15. Transcriptional regulation of mitochondrial HMG-CoA synthase in the control of ketogenesis. Hegardt FG Biochimie. 1998 Oct;80(10):803-6.
16. Molecular mechanism investigation of phenobarbital-induced serum cholesterol elevation in rat livers by microarray analysis. Kiyosawa N, etal., Arch Toxicol. 2004 Aug;78(8):435-42. Epub 2004 Apr 24.
17. Differential action of 13-HPODE on PPARalpha downstream genes in rat Fao and human HepG2 hepatoma cell lines. Konig B and Eder K, J Nutr Biochem. 2006 Jun;17(6):410-8. Epub 2005 Sep 23.
18. Identification of palmitoylated mitochondrial proteins using a bio-orthogonal azido-palmitate analogue. Kostiuk MA, etal., FASEB J. 2008 Mar;22(3):721-32. Epub 2007 Oct 30.
19. Impaired ketogenesis is a major mechanism for disturbed hepatic fatty acid metabolism in rats with long-term cholestasis and after relief of biliary obstruction. Lang C, etal., J Hepatol. 2002 Nov;37(5):564-71.
20. Post-transcriptional induction of beta 1-adrenergic receptor by retinoic acid, but not triiodothyronine, in C6 glioma cells expressing thyroid hormone receptors. Lopez-Barahona M, etal., Eur J Endocrinol. 1996 Dec;135(6):709-15.
21. Mitochondrial 3-hydroxy-3-methylglutaryl coenzyme A synthase and carnitine palmitoyltransferase II as potential control sites for ketogenesis during mitochondrion and peroxisome proliferation. Madsen L, etal., Biochem Pharmacol. 1999 May 1;57(9):1011-9.
22. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
23. Down-regulation of the mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase gene by insulin: the role of the forkhead transcription factor FKHRL1. Nadal A, etal., Biochem J. 2002 Aug 15;366(Pt 1):289-97.
24. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
25. Effect of squalene synthase inhibition on the expression of hepatic cholesterol biosynthetic enzymes, LDL receptor, and cholesterol 7 alpha hydroxylase. Ness GC, etal., Arch Biochem Biophys. 1994 Jun;311(2):277-85.
26. Two-dimensional electrophoresis of liver proteins: characterization of a drug-induced hepatomegaly in rats. Newsholme SJ, etal., Electrophoresis. 2000 Jun;21(11):2122-8.
27. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
28. Analysis of genes differentially expressed in astrocytes stimulated with lipopolysaccharide using cDNA arrays. Pang Y, etal., Brain Res. 2001 Sep 28;914(1-2):15-22.
29. Acetoacetate metabolism in rat brain. Development of acetoacetyl-coenzyme A deacylase and 3-hydroxy-3-methylglutaryl-coenzyme A synthase. Patel TB and Clark JB, Biochem J. 1978 Dec 15;176(3):951-8.
30. Effects of 4-hydroxynonenal on mitochondrial 3-hydroxy-3-methylglutaryl (HMG-CoA) synthase. Patel VB, etal., Free Radic Biol Med. 2007 Dec 1;43(11):1499-507. Epub 2007 Aug 16.
31. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
32. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
33. Glucagon activates mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase in vivo by decreasing the extent of succinylation of the enzyme. Quant PA, etal., Eur J Biochem. 1990 Jan 12;187(1):169-74.
34. GOA pipeline RGD automated data pipeline
35. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
36. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
37. Peroxisome proliferator-activated receptor mediates induction of the mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase gene by fatty acids. Rodriguez JC, etal., J Biol Chem. 1994 Jul 22;269(29):18767-72.
38. Restraint stress alters the duodenal expression of genes important for lipid metabolism in rat. Sato T, etal., Toxicology. 2006 Oct 29;227(3):248-61. Epub 2006 Aug 14.
39. Regulation of mitochondrial 3-hydroxy-3-methylglutaryl-coenzyme A synthase protein by starvation, fat feeding, and diabetes. Serra D, etal., Arch Biochem Biophys. 1993 Nov 15;307(1):40-5.
40. The expression of mitochondrial 3-hydroxy-3-methylglutaryl-coenzyme-A synthase in neonatal rat intestine and liver is under transcriptional control. Serra D, etal., Eur J Biochem. 1996 Apr 1;237(1):16-24.
41. Cholesterol biosynthesis regulation and protein changes in rat liver following treatment with fluvastatin. Steiner S, etal., Toxicol Lett. 2001 Mar 31;120(1-3):369-77.
42. Opposite effect of prolactin and prostaglandin F(2 alpha) on the expression of luteal genes as revealed by rat cDNA expression array. Stocco C, etal., Endocrinology. 2001 Sep;142(9):4158-61.
43. miR-107-mediated decrease of HMGCS2 indicates poor outcomes and promotes cell migration in hepatocellular carcinoma. Su SG, etal., Int J Biochem Cell Biol. 2017 Oct;91(Pt A):53-59. doi: 10.1016/j.biocel.2017.08.016. Epub 2017 Sep 1.
44. Developmental changes in mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase gene expression in rat liver, intestine and kidney. Thumelin S, etal., Biochem J. 1993 Jun 1;292 ( Pt 2):493-6.
45. Atypical expression of mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase in subcutaneous adipose tissue of male rats. Thumelin S, etal., J Lipid Res. 1999 Jun;40(6):1071-7.
46. Vanadate treatment restores the expression of genes for key enzymes in the glucose and ketone bodies metabolism in the liver of diabetic rats. Valera A, etal., J Clin Invest. 1993 Jul;92(1):4-11.
47. Mitochondrial HMG-CoA synthase partially contributes to antioxidant protection in the kidney of stroke-prone spontaneously hypertensive rats. Yi W, etal., Nutrition. 2010 Feb 3.
Additional References at PubMed
PMID:12477932   PMID:12865426   PMID:14651853   PMID:15254779   PMID:18614015   PMID:20346956   PMID:23486364   PMID:23751782   PMID:24315375   PMID:25931508   PMID:26767982   PMID:27671501  
PMID:36281857   PMID:38477658  


Genomics

Comparative Map Data
Hmgcs2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82188,564,348 - 188,590,872 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl2188,547,767 - 188,592,242 (+)EnsemblGRCr8
mRatBN7.22185,875,609 - 185,903,505 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2185,875,616 - 185,902,130 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx2193,524,494 - 193,551,482 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02191,333,168 - 191,359,836 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02186,157,074 - 186,184,065 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.02200,452,623 - 200,480,785 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2200,452,624 - 200,479,423 (+)Ensemblrn6Rnor6.0
Rnor_5.02219,928,546 - 219,956,233 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.42193,128,736 - 193,143,106 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera2178,363,353 - 178,390,245 (+)NCBICelera
RGSC_v3.12193,091,489 - 193,105,860 (+)NCBI
Cytogenetic Map2q34NCBI
HMGCS2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381119,747,996 - 119,768,932 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1119,747,979 - 119,769,092 (-)Ensemblhg38GRCh38
GRCh371120,290,619 - 120,311,555 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361120,092,525 - 120,113,041 (-)NCBIBuild 36Build 36hg18NCBI36
Build 341120,003,046 - 120,023,560NCBI
Celera1118,521,355 - 118,542,283 (-)NCBICelera
Cytogenetic Map1p12NCBI
HuRef1118,149,159 - 118,170,093 (-)NCBIHuRef
CHM1_11120,406,161 - 120,427,088 (-)NCBICHM1_1
T2T-CHM13v2.01119,761,239 - 119,782,165 (-)NCBIT2T-CHM13v2.0
Hmgcs2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39398,187,747 - 98,218,054 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl398,187,751 - 98,218,054 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38398,280,431 - 98,310,738 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl398,280,435 - 98,310,738 (+)Ensemblmm10GRCm38
MGSCv37398,084,354 - 98,114,661 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36398,365,840 - 98,396,137 (+)NCBIMGSCv36mm8
Celera399,679,562 - 99,709,869 (+)NCBICelera
Cytogenetic Map3F2.2NCBI
cM Map342.74NCBI
Hmgcs2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543522,804,484 - 22,821,482 (-)Ensembl
ChiLan1.0NW_00495543522,804,484 - 22,820,807 (-)NCBIChiLan1.0ChiLan1.0
HMGCS2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21112,370,431 - 112,392,565 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11111,972,859 - 111,994,914 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0182,778,489 - 82,798,987 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11117,776,165 - 117,796,679 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1117,775,770 - 117,796,679 (+)EnsemblpanPan2panpan1.1
HMGCS2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11756,679,942 - 56,698,521 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1756,680,301 - 56,698,419 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1756,315,432 - 56,328,270 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01757,558,992 - 57,577,456 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1757,554,455 - 57,577,399 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11756,594,625 - 56,613,171 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01756,620,825 - 56,639,082 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01757,237,948 - 57,256,436 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Hmgcs2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505810,015,851 - 10,037,163 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366274,451,823 - 4,473,223 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049366274,451,847 - 4,473,163 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LOC110260333
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl4101,385,512 - 101,443,405 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.14101,385,486 - 101,404,273 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
HMGCS2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12014,018,669 - 14,040,934 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2014,019,692 - 14,041,016 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366603816,649,801 - 16,670,981 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Hmgcs2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462477215,432,198 - 15,467,797 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462477215,432,612 - 15,464,343 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Hmgcs2
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1359,008,523 - 59,032,323 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Hmgcs2
227 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:181
Count of miRNA genes:126
Interacting mature miRNAs:143
Transcripts:ENSRNOT00000026121
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1358356Srcrt1Stress Responsive Cort QTL13.66blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)2163997722225110681Rat
1578648Bss11Bone structure and strength QTL 114.7femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)2169358774214358774Rat
1331734Bp204Blood pressure QTL 2043.61192arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2170656145239614549Rat
631566Bp90Blood pressure QTL 900.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2149957381221199885Rat
1298074Bp164Blood pressure QTL 1640.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)244537979205135428Rat
1354648Bp239Blood pressure QTL 2390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)267845370229470703Rat
1354649Kidm17Kidney mass QTL 172.9kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)283465462229820014Rat
10755499Bp389Blood pressure QTL 3892.61arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)220695736231474293Rat
1298076Bp166Blood pressure QTL 1660.0009arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2138595962205135428Rat
1581576Pur7Proteinuria QTL 70.0001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)280396178220931218Rat
152025245Scl81Serum cholesterol level QTL 813.49blood cholesterol amount (VT:0000180)2124537199209621565Rat
1581578Cm49Cardiac mass QTL 494.90.01heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)2145807215220931416Rat
631198Cm22Cardiac mass QTL 224.30.0008heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)278269809208420281Rat
1554319Bmd2Bone mineral density QTL 213.40.0001lumbar vertebra area (VT:0010570)lumbar vertebra cross-sectional area (CMO:0001689)2122597372215234002Rat
12879836Kidm61Kidney mass QTL 610.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)2154723085199723085Rat
1581569Uae32Urinary albumin excretion QTL 320.0001urine protein amount (VT:0005160)urine albumin excretion rate (CMO:0000757)280396178220931218Rat
10043136Iddm54Insulin dependent diabetes mellitus QTL 543.40.0001blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)2145807215190807215Rat
12879837Am2Aortic mass QTL 20.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)2154723085199723085Rat
10043139Iddm55Insulin dependent diabetes mellitus QTL 553.10.0001blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)2150313808195313808Rat
12879838Cm86Cardiac mass QTL 860.002heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)2154723085199723085Rat
1302793Bw16Body weight QTL 1650.0001body mass (VT:0001259)body weight (CMO:0000012)2159440891205135267Rat
12879839Cm85Cardiac mass QTL 850.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)2154723085199723085Rat
1549833Bp257Blood pressure QTL 2570.003arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2170652929215652929Rat
1358900Bw48Body weight QTL 484.88body mass (VT:0001259)body weight (CMO:0000012)2159440891220931218Rat
4889834Pur24Proteinuria QTL 245.80.014urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)2171994826205135428Rat
1359030Bp277Blood pressure QTL 277arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2143565208188565208Rat
1359031Bp275Blood pressure QTL 275arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2188565047233565047Rat
1331760Bp206Blood pressure QTL 2063.62454arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)24265106205135428Rat
12879840Bw179Body weight QTL 1790.005body mass (VT:0001259)body weight (CMO:0000012)2154723085199723085Rat
1581502Esta3Estrogen-induced thymic atrophy QTL 3thymus mass (VT:0004954)thymus wet weight (CMO:0000855)2139067258192287892Rat
9589044Scfw1Subcutaneous fat weight QTL 15.80.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)2184856304229856304Rat
8694435Bw166Body weight QTL 16614.080.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)2184856304229856304Rat
1359032Hrtrt18Heart rate QTL 18heart pumping trait (VT:2000009)heart rate (CMO:0000002)2159440760195313808Rat
2301966Bp322Blood pressure QTL 3223.58arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2144882354205135428Rat
1298080Bp163Blood pressure QTL 1630.02arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)267845182205135428Rat
1357991Ael2Aortic elastin QTL 24.20.000071aorta elastin amount (VT:0003905)aortic elastin2169227906214227906Rat
8662832Vetf7Vascular elastic tissue fragility QTL 73.5aorta elastin amount (VT:0003905)aorta wall extracellular elastin dry weight to aorta wall dry weight ratio (CMO:0002002)283400752223709938Rat
1298085Bp165Blood pressure QTL 1650.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)244537979205135428Rat
8694194Abfw1Abdominal fat weight QTL 111.70.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)2184856304229856304Rat
1578671Bmd10Bone mineral density QTL 105.4femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)2175931416220931416Rat
1641891Alcrsp17Alcohol response QTL 17response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2151869660251712708Rat
724534Uae6Urinary albumin excretion QTL 610urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)280396034220931416Rat
61374Edpm2Estrogen-dependent pituitary mass QTL 24.420.86pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)278269809205135428Rat
2300189Bmd48Bone mineral density QTL 485.80.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)2182024327227024327Rat
8662843Vetf9Vascular elastic tissue fragility QTL 92.05thoracic aorta molecular composition trait (VT:0010568)aorta wall extracellular elastin dry weight to aorta wall extracellular collagen weight ratio (CMO:0002003)2159440760228950743Rat
2301408Kidm36Kidney mass QTL 360.002kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)2184482291229482291Rat
1331794Bp202Blood pressure QTL 2023.66819arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2143344967251712708Rat
71113Cari2Carrageenan-induced inflammation QTL 22.70.009hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)2143746578205135428Rat
1331805Cm29Cardiac mass QTL 293.50746heart mass (VT:0007028)heart wet weight (CMO:0000069)2143344967251712708Rat
634308Sach6Saccharin preference QTL 64.9taste sensitivity trait (VT:0001986)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)2114384617215381366Rat
1598805Memor8Memory QTL 83exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)2150096616195096616Rat
1358917Cm42Cardiac mass QTL 422.82heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328206613235Rat
724568Uae13Urinary albumin excretion QTL 134.4urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)2145306936212705578Rat
7488929Bp366Blood pressure QTL 3660.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2187663373195783351Rat
1358913Cm41Cardiac mass QTL 412.73heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328206613235Rat
1300165Rf9Renal function QTL 93.28kidney glomerulus integrity trait (VT:0010546)index of glomerular damage (CMO:0001135)2113746222205135428Rat
738013Alc15Alcohol consumption QTL 154.10.00022consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)2186850607231850607Rat
61401Niddm2Non-insulin dependent diabetes mellitus QTL 24.54blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)2147287892192287892Rat
631507Bp105Blood pressure QTL 1050.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2114384617215381366Rat
1641925Alcrsp2Alcohol response QTL 2response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2151869660223841096Rat
1354609Niddm62Non-insulin dependent diabetes mellitus QTL 624.720.000006insulin secretion trait (VT:0003564)plasma insulin level (CMO:0000342)2117415288205135428Rat
1598833Bp295Blood pressure QTL 2953.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2150096616195096616Rat
61417Cia10Collagen induced arthritis QTL 103.4joint integrity trait (VT:0010548)experimental arthritis severity measurement (CMO:0001459)2182635347227635347Rat
1354622Kidm16Kidney mass QTL 163kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)283465462225110681Rat
631266Bp132Blood pressure QTL 1320.0005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)247856345205135428Rat
631522Bp74Blood pressure QTL 740.05arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2175008837220008837Rat
8694383Bw158Body weight QTL 1587.690.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)2184856304229856304Rat
7488927Bp365Blood pressure QTL 3650.008arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2165453811210453811Rat
7488925Bp364Blood pressure QTL 3640.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2163253030208253030Rat
2306901Bp337Blood pressure QTL 3370.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2166372086229820014Rat
1354605Rf48Renal function QTL 482.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)276328396209350714Rat

Markers in Region
D2Mgh10  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr82188,565,047 - 188,565,208 (+)Marker Load Pipeline
mRatBN7.22185,876,309 - 185,876,470 (+)MAPPERmRatBN7.2
Rnor_6.02200,453,324 - 200,453,484NCBIRnor6.0
Rnor_5.02219,929,245 - 219,929,405UniSTSRnor5.0
Celera2178,364,029 - 178,364,187UniSTS
RH 3.4 Map21255.3UniSTS
RH 3.4 Map21255.3RGD
RH 2.0 Map2947.3RGD
SHRSP x BN Map272.7698RGD
Cytogenetic Map2q34UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 153 91 90 59 61 59 6 323 159 9 134 81 92 31 14 14

Sequence


Ensembl Acc Id: ENSRNOT00000026121   ⟹   ENSRNOP00000026122
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2188,547,772 - 188,592,242 (+)Ensembl
mRatBN7.2 Ensembl2185,875,616 - 185,902,130 (+)Ensembl
Rnor_6.0 Ensembl2200,452,624 - 200,479,423 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000163966   ⟹   ENSRNOP00000109003
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2188,547,767 - 188,592,242 (+)Ensembl
RefSeq Acc Id: NM_173094   ⟹   NP_775117
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82188,564,372 - 188,590,872 (+)NCBI
mRatBN7.22185,875,634 - 185,902,134 (+)NCBI
Rnor_6.02200,452,648 - 200,479,415 (+)NCBI
Rnor_5.02219,928,546 - 219,956,233 (+)NCBI
RGSC_v3.42193,128,736 - 193,143,106 (+)RGD
Celera2178,363,353 - 178,390,245 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006233002   ⟹   XP_006233064
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82188,564,348 - 188,590,869 (+)NCBI
mRatBN7.22185,875,609 - 185,903,505 (+)NCBI
Rnor_6.02200,452,623 - 200,480,785 (+)NCBI
Rnor_5.02219,928,546 - 219,956,233 (+)NCBI
Sequence:
RefSeq Acc Id: NP_775117   ⟸   NM_173094
- Peptide Label: precursor
- UniProtKB: P22791 (UniProtKB/Swiss-Prot),   F1M9Q5 (UniProtKB/Swiss-Prot),   Q68G44 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006233064   ⟸   XM_006233002
- Peptide Label: isoform X1
- UniProtKB: P22791 (UniProtKB/Swiss-Prot),   F1M9Q5 (UniProtKB/Swiss-Prot),   Q68G44 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000026122   ⟸   ENSRNOT00000026121
Ensembl Acc Id: ENSRNOP00000109003   ⟸   ENSRNOT00000163966

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P22791-F1-model_v2 AlphaFold P22791 1-508 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13691601
Promoter ID:EPDNEW_R2126
Type:multiple initiation site
Name:Hmgcs2_1
Description:3-hydroxy-3-methylglutaryl-CoA synthase 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.02200,452,630 - 200,452,690EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2804 AgrOrtholog
BioCyc Gene G2FUF-51917 BioCyc
BioCyc Pathway PWY-922 [mevalonate pathway I (eukaryotes and bacteria)] BioCyc
  PWY66-367 [ketogenesis] BioCyc
BioCyc Pathway Image PWY-922 BioCyc
  PWY66-367 BioCyc
Ensembl Genes ENSRNOG00000019120 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000026121 ENTREZGENE
  ENSRNOT00000026121.8 UniProtKB/Swiss-Prot
Gene3D-CATH 3.40.47.10 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7112644 IMAGE-MGC_LOAD
  IMAGE:7132009 IMAGE-MGC_LOAD
InterPro HMG_CoA_synt_AS UniProtKB/Swiss-Prot
  HMG_CoA_synt_C_dom UniProtKB/Swiss-Prot
  HMG_CoA_synth_N UniProtKB/Swiss-Prot
  HMG_CoA_synthase_euk UniProtKB/Swiss-Prot
  Thiolase-like UniProtKB/Swiss-Prot
KEGG Report rno:24450 UniProtKB/Swiss-Prot
MGC_CLONE MGC:93080 IMAGE-MGC_LOAD
  MGC:93081 IMAGE-MGC_LOAD
NCBI Gene 24450 ENTREZGENE
PANTHER 3-HYDROXY-3-METHYLGLUTARYL COENZYME A SYNTHASE UniProtKB/Swiss-Prot
  HYDROXYMETHYLGLUTARYL-COA SYNTHASE, MITOCHONDRIAL UniProtKB/Swiss-Prot
Pfam HMG_CoA_synt_C UniProtKB/Swiss-Prot
  HMG_CoA_synt_N UniProtKB/Swiss-Prot
PhenoGen Hmgcs2 PhenoGen
PROSITE HMG_COA_SYNTHASE UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000019120 RatGTEx
Superfamily-SCOP SSF53901 UniProtKB/Swiss-Prot
UniProt A0ABK0LUH5_RAT UniProtKB/TrEMBL
  F1M9Q5 ENTREZGENE
  HMCS2_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q68G44 ENTREZGENE
UniProt Secondary F1M9Q5 UniProtKB/Swiss-Prot
  Q68G44 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-01-27 Hmgcs2  3-hydroxy-3-methylglutaryl-CoA synthase 2  Hmgcs2  3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2011-08-02 Hmgcs2  3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial)  Hmgcs2  3-hydroxy-3-methylglutaryl-Coenzyme A synthase 2 (mitochondrial)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-24 Hmgcs2  3-hydroxy-3-methylglutaryl-Coenzyme A synthase 2 (mitochondrial)  Hmgcs2  3-hydroxy-3-methylglutaryl-Coenzyme A synthase 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-02-27 Hmgcs2  3-hydroxy-3-methylglutaryl-Coenzyme A synthase 2      Typo in previous name 70292 APPROVED
2001-10-23 Hmgcs2  3-hydroxy-3-methylglutary-Coenzyme A synthase 2      Name updated to reflect Human and Mouse nomenclature 68913 APPROVED
2001-10-23 Hmgcs2  3-hydroxy-3-methylglutary-Coenzyme A synthase      Name withdrawn 68913 WITHDRAWN