Hagh (hydroxyacyl glutathione hydrolase) - Rat Genome Database

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Gene: Hagh (hydroxyacyl glutathione hydrolase) Rattus norvegicus
Analyze
Symbol: Hagh
Name: hydroxyacyl glutathione hydrolase
RGD ID: 2779
Description: Enables hydroxyacylglutathione hydrolase activity. Involved in glutathione metabolic process. Predicted to be located in mitochondrial matrix. Predicted to be active in mitochondrion. Orthologous to human HAGH (hydroxyacylglutathione hydrolase); PARTICIPATES IN glyoxalase metabolic pathway; Leigh disease pathway; primary hyperoxaluria type 2 pathway; INTERACTS WITH 1-naphthyl isothiocyanate; 2,3,7,8-tetrachlorodibenzodioxine; 4,4'-diaminodiphenylmethane.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Glo2; glx II; glyoxalase II; hydroxyacylglutathione hydrolase; hydroxyacylglutathione hydrolase, mitochondrial; round spermatid protein RSP29; RSP29
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81014,379,400 - 14,394,046 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1014,382,410 - 14,394,043 (+)EnsemblGRCr8
mRatBN7.21013,874,883 - 13,889,527 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1013,875,241 - 13,889,504 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1018,622,292 - 18,636,594 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01018,111,152 - 18,125,454 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01013,610,369 - 13,624,671 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01014,215,913 - 14,230,506 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1014,216,155 - 14,230,515 (+)Ensemblrn6Rnor6.0
Rnor_5.01014,032,006 - 14,046,521 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41014,106,047 - 14,117,459 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1013,554,443 - 13,568,735 (+)NCBICelera
RGSC_v3.11014,106,046 - 14,117,459 (+)NCBI
Cytogenetic Map10q12NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(S)-colchicine  (ISO)
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (EXP)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
3,3',4,4'-tetrachlorobiphenyl  (ISO)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (ISO)
acetamide  (EXP)
acrylamide  (ISO)
actinomycin D  (ISO)
aflatoxin B1  (ISO)
alpha-Zearalanol  (EXP)
ammonium chloride  (EXP)
aristolochic acid A  (ISO)
arsenous acid  (ISO)
benzo[a]pyrene  (ISO)
beta-naphthoflavone  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
Butylbenzyl phthalate  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
carmustine  (ISO)
chrysene  (ISO)
cisplatin  (ISO)
clofibrate  (EXP)
copper atom  (EXP)
copper(0)  (EXP)
copper(II) sulfate  (ISO)
cyclosporin A  (EXP,ISO)
DDE  (ISO)
diarsenic trioxide  (ISO)
diazinon  (ISO)
elemental selenium  (ISO)
ethanol  (ISO)
fenvalerate  (EXP)
fumonisin B1  (ISO)
gentamycin  (EXP)
Heptachlor epoxide  (ISO)
ivermectin  (ISO)
methylglyoxal  (ISO)
N-nitrosodiethylamine  (EXP)
nefazodone  (EXP)
nitrofen  (EXP)
Nutlin-3  (ISO)
O-methyleugenol  (ISO)
ochratoxin A  (EXP)
okadaic acid  (ISO)
paracetamol  (EXP,ISO)
perfluorononanoic acid  (ISO)
perfluorooctanoic acid  (EXP)
pirinixic acid  (ISO)
selenium atom  (ISO)
silicon dioxide  (ISO)
temozolomide  (ISO)
tetrachloromethane  (ISO)
thapsigargin  (EXP)
thioacetamide  (EXP)
titanium dioxide  (ISO)
trichostatin A  (ISO)
triphenyl phosphate  (ISO)
troglitazone  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
vitamin E  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IEA,ISO)
mitochondrial matrix  (IEA,ISO)
mitochondrion  (IBA,ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. cDNA cloning and characterization of a rat spermatogenesis-associated protein RSP29. Ji X, etal., Biochem Biophys Res Commun 1997 Dec 29;241(3):714-9.
4. Contents of D-lactate and its related metabolites as well as enzyme activities in the liver, muscle and blood plasma of aging rats. Kawase M, etal., Mech Ageing Dev. 1995 Sep 29;84(1):55-63.
5. Changes in concentrations of methylglyoxal, D-lactate and glyoxalase activities in liver and plasma of rats fed a 3'-methyl-4-dimethylaminoazobenzene-rich diet. Kawase M, etal., Res Exp Med (Berl). 1996;196(4):251-9.
6. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
7. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
8. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
9. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
10. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
11. GOA pipeline RGD automated data pipeline
12. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:1914521   PMID:8550579   PMID:12477932   PMID:15117945   PMID:18614015   PMID:22171037   PMID:22893478   PMID:23376485   PMID:34800366  


Genomics

Comparative Map Data
Hagh
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81014,379,400 - 14,394,046 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1014,382,410 - 14,394,043 (+)EnsemblGRCr8
mRatBN7.21013,874,883 - 13,889,527 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1013,875,241 - 13,889,504 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1018,622,292 - 18,636,594 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01018,111,152 - 18,125,454 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01013,610,369 - 13,624,671 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01014,215,913 - 14,230,506 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1014,216,155 - 14,230,515 (+)Ensemblrn6Rnor6.0
Rnor_5.01014,032,006 - 14,046,521 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41014,106,047 - 14,117,459 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1013,554,443 - 13,568,735 (+)NCBICelera
RGSC_v3.11014,106,046 - 14,117,459 (+)NCBI
Cytogenetic Map10q12NCBI
HAGH
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38161,807,629 - 1,827,194 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl161,795,620 - 1,827,157 (-)Ensemblhg38GRCh38
GRCh37161,857,630 - 1,877,195 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36161,799,105 - 1,817,196 (-)NCBIBuild 36Build 36hg18NCBI36
Build 34161,799,105 - 1,817,163NCBI
Celera162,071,349 - 2,089,441 (-)NCBICelera
Cytogenetic Map16p13.3NCBI
HuRef161,781,967 - 1,800,219 (-)NCBIHuRef
CHM1_1161,859,060 - 1,877,163 (-)NCBICHM1_1
T2T-CHM13v2.0161,823,468 - 1,843,048 (-)NCBIT2T-CHM13v2.0
Hagh
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391725,056,863 - 25,083,424 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1725,059,117 - 25,083,424 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381724,839,781 - 24,864,450 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1724,840,143 - 24,864,450 (+)Ensemblmm10GRCm38
MGSCv371724,987,435 - 25,001,395 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361724,578,147 - 24,592,050 (+)NCBIMGSCv36mm8
Celera1725,377,454 - 25,391,223 (+)NCBICelera
Cytogenetic Map17A3.3NCBI
cM Map1712.53NCBI
Hagh
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544215,451,910 - 15,465,211 (+)Ensembl
ChiLan1.0NW_00495544215,451,910 - 15,465,211 (+)NCBIChiLan1.0ChiLan1.0
LOC100992459
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2182,075,668 - 2,122,827 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1165,857,103 - 5,880,906 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v016431,417 - 455,211 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1161,864,372 - 1,865,276 (-)NCBIPanPan1.1PanPan1.1panPan2
HAGH
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1639,076,364 - 39,105,646 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl639,084,513 - 39,105,592 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha640,323,559 - 40,344,553 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0639,400,917 - 39,422,090 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl639,375,311 - 39,422,080 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1639,077,630 - 39,098,788 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0639,050,207 - 39,071,366 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0639,528,902 - 39,549,839 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Hagh
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024409344104,510,713 - 104,528,007 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366942,181,501 - 2,194,007 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049366942,181,475 - 2,200,469 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HAGH
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1340,139,099 - 40,162,921 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
HAGH
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.151,705,436 - 1,730,896 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl51,713,542 - 1,730,797 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366606829,352,945 - 29,370,176 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Hagh
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624913434,537 - 446,061 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_004624913426,554 - 446,061 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Hagh
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v192,134,881 - 2,149,416 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Hagh
47 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:89
Count of miRNA genes:83
Interacting mature miRNAs:85
Transcripts:ENSRNOT00000020192
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2313095Bss62Bone structure and strength QTL 621.50.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)10589381150893811Rat
631660Hcar1Hepatocarcinoma resistance QTL 13.40.0001liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)10666111835509383Rat
8662860Vetf10Vascular elastic tissue fragility QTL 10artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)10666092373950353Rat
2313066Bss63Bone structure and strength QTL 631.40.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)10589381150893811Rat
631554Bp133Blood pressure QTL 1330.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)10125055464349221Rat
2313064Bmd71Bone mineral density QTL 710.90.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)10589381150893811Rat
1578761Stresp21Stress response QTL 213.3thymus mass (VT:0004954)thymus wet weight (CMO:0000855)10687714251877142Rat
2293680Bss40Bone structure and strength QTL 405.660.0001femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)10135730538Rat
7387235Uae41Urinary albumin excretion QTL 415.260.1874urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)10130004247Rat
2313104Bss61Bone structure and strength QTL 610.90.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)10589381150893811Rat
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10686461896620484Rat
10401803Kidm50Kidney mass QTL 50kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1092219745922197Rat
2317754Glom25Glomerulus QTL 253.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)10210370847103708Rat
2313081Bss64Bone structure and strength QTL 641.30.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)10589381150893811Rat
631828Alc5Alcohol consumption QTL 52.4consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)10117749933Rat
634327Hc4Hypercalciuria QTL 42.4urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)10138832698Rat

Markers in Region
RH133587  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21013,873,671 - 13,873,891 (+)MAPPERmRatBN7.2
Rnor_6.01014,214,651 - 14,214,870NCBIRnor6.0
Rnor_5.01014,030,666 - 14,030,885UniSTSRnor5.0
RGSC_v3.41014,101,757 - 14,101,976UniSTSRGSC3.4
Celera1013,552,881 - 13,553,100UniSTS
Cytogenetic Map10q12UniSTS
D10Bda1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21013,888,800 - 13,889,419 (+)MAPPERmRatBN7.2
Rnor_6.01014,229,780 - 14,230,398NCBIRnor6.0
Rnor_5.01014,045,795 - 14,046,413UniSTSRnor5.0
RGSC_v3.41014,116,886 - 14,117,504UniSTSRGSC3.4
Celera1013,568,009 - 13,568,627UniSTS
Cytogenetic Map10q12UniSTS
RH141944  
Rat AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map10q12UniSTS
MARC_5473-5474:996690420:1  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81014,382,535 - 14,383,296 (+)Marker Load Pipeline
mRatBN7.21013,878,016 - 13,878,777 (+)MAPPERmRatBN7.2
Rnor_6.01014,218,996 - 14,219,756NCBIRnor6.0
Rnor_5.01014,035,011 - 14,035,771UniSTSRnor5.0
RGSC_v3.41014,106,102 - 14,106,862UniSTSRGSC3.4
Celera1013,557,225 - 13,557,985UniSTS
Cytogenetic Map10q12UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000020192   ⟹   ENSRNOP00000020192
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1014,382,410 - 14,394,043 (+)Ensembl
mRatBN7.2 Ensembl1013,875,241 - 13,889,504 (+)Ensembl
Rnor_6.0 Ensembl1014,216,155 - 14,230,515 (+)Ensembl
RefSeq Acc Id: NM_033349   ⟹   NP_203500
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81014,379,753 - 14,394,046 (+)NCBI
mRatBN7.21013,875,234 - 13,889,527 (+)NCBI
Rnor_6.01014,216,213 - 14,230,506 (+)NCBI
Rnor_5.01014,032,006 - 14,046,521 (+)NCBI
RGSC_v3.41014,106,047 - 14,117,459 (+)RGD
Celera1013,554,443 - 13,568,735 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006245899   ⟹   XP_006245961
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81014,379,891 - 14,394,046 (+)NCBI
mRatBN7.21013,875,295 - 13,889,527 (+)NCBI
Rnor_6.01014,216,322 - 14,230,506 (+)NCBI
Rnor_5.01014,032,006 - 14,046,521 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006245900   ⟹   XP_006245962
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81014,379,400 - 14,394,046 (+)NCBI
mRatBN7.21013,874,883 - 13,889,527 (+)NCBI
Rnor_6.01014,215,913 - 14,230,506 (+)NCBI
Rnor_5.01014,032,006 - 14,046,521 (+)NCBI
Sequence:
RefSeq Acc Id: XM_063268398   ⟹   XP_063124468
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81014,382,536 - 14,394,046 (+)NCBI
RefSeq Acc Id: NP_203500   ⟸   NM_033349
- Peptide Label: precursor
- UniProtKB: Q4V8M8 (UniProtKB/Swiss-Prot),   O35952 (UniProtKB/Swiss-Prot),   A6HCX7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006245962   ⟸   XM_006245900
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_006245961   ⟸   XM_006245899
- Peptide Label: isoform X1
- Sequence:
Ensembl Acc Id: ENSRNOP00000020192   ⟸   ENSRNOT00000020192
RefSeq Acc Id: XP_063124468   ⟸   XM_063268398
- Peptide Label: isoform X2
Protein Domains
Metallo-beta-lactamase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O35952-F1-model_v2 AlphaFold O35952 1-309 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13697030
Promoter ID:EPDNEW_R7555
Type:initiation region
Name:Hagh_1
Description:hydroxyacyl glutathione hydrolase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01014,216,220 - 14,216,280EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2779 AgrOrtholog
BioCyc Gene G2FUF-25820 BioCyc
Ensembl Genes ENSRNOG00000014743 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000020192 ENTREZGENE
Gene3D-CATH 3.60.15.10 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7460472 IMAGE-MGC_LOAD
InterPro Clx_II_MBL UniProtKB/Swiss-Prot
  HAGH_C UniProtKB/Swiss-Prot
  Hydroxyacylglutathione_Hdrlase UniProtKB/Swiss-Prot
  Metallo-B-lactamas UniProtKB/Swiss-Prot
  RibonucZ/Hydroxyglut_hydro UniProtKB/Swiss-Prot
KEGG Report rno:24439 UniProtKB/Swiss-Prot
MGC_CLONE MGC:114294 IMAGE-MGC_LOAD
NCBI Gene 24439 ENTREZGENE
PANTHER BETA LACTAMASE DOMAIN UniProtKB/Swiss-Prot
  HYDROXYACYLGLUTATHIONE HYDROLASE, MITOCHONDRIAL UniProtKB/Swiss-Prot
Pfam HAGH_C UniProtKB/Swiss-Prot
  Lactamase_B UniProtKB/Swiss-Prot
PhenoGen Hagh PhenoGen
PIRSF Glx UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000014743 RatGTEx
SMART Lactamase_B UniProtKB/Swiss-Prot
Superfamily-SCOP SSF56281 UniProtKB/Swiss-Prot
UniProt A6HCX7 ENTREZGENE, UniProtKB/TrEMBL
  F1LQI1_RAT UniProtKB/TrEMBL
  GLO2_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q4V8M8 ENTREZGENE
UniProt Secondary Q4V8M8 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Hagh  Hydroxyacyl glutathione hydrolase      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_evolution predicted protein sequence is highly conserved among eukaryotes 728643
gene_expression mRNA is expressed in many tissues, particularly in the testis 728643