Gucy2c (guanylate cyclase 2C) - Rat Genome Database

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Gene: Gucy2c (guanylate cyclase 2C) Rattus norvegicus
Analyze
Symbol: Gucy2c
Name: guanylate cyclase 2C
RGD ID: 2771
Description: Enables guanylate cyclase activity and toxic substance binding activity. Predicted to be involved in cGMP biosynthetic process and receptor guanylyl cyclase signaling pathway. Predicted to act upstream of or within regulation of cell population proliferation and response to toxic substance. Predicted to be located in endoplasmic reticulum membrane. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in congenital diarrhea 6. Orthologous to human GUCY2C (guanylate cyclase 2C); PARTICIPATES IN purine metabolic pathway; INTERACTS WITH (+)-schisandrin B; 1,2-dimethylhydrazine; 1-naphthyl isothiocyanate.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: GC-C; GCC; Guanylate cyclase 2C (heat stable enterotoxin receptor); guanylyl cyclase C; heat-stable enterotoxin receptor; intestinal guanylate cyclase; LOC100359629; STA receptor
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84171,299,715 - 171,380,296 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl4171,299,740 - 171,380,296 (-)EnsemblGRCr8
mRatBN7.24169,568,505 - 169,649,092 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4169,568,529 - 169,649,092 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx4175,864,053 - 175,943,958 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04171,644,965 - 171,725,559 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04170,269,703 - 170,349,616 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.04170,659,993 - 170,740,274 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4170,659,998 - 170,740,274 (-)Ensemblrn6Rnor6.0
Rnor_5.04234,917,953 - 234,998,564 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.44173,740,202 - 173,791,116 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera4158,151,931 - 158,232,578 (-)NCBICelera
RGSC_v3.14173,985,329 - 174,036,240 (-)NCBI
RH 3.4 Map41029.8RGD
Cytogenetic Map4q43NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
4. High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
5. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
6. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
7. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
8. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
9. GOA pipeline RGD automated data pipeline
10. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
11. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
12. Guanylyl cyclase is a heat-stable enterotoxin receptor. Schulz S, etal., Cell 1990 Nov 30;63(5):941-8.
13. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
Additional References at PubMed
PMID:9294128   PMID:14561709   PMID:17681179   PMID:19648115   PMID:21106860   PMID:23081987   PMID:26249840   PMID:29097254  


Genomics

Comparative Map Data
Gucy2c
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84171,299,715 - 171,380,296 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl4171,299,740 - 171,380,296 (-)EnsemblGRCr8
mRatBN7.24169,568,505 - 169,649,092 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4169,568,529 - 169,649,092 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx4175,864,053 - 175,943,958 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04171,644,965 - 171,725,559 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04170,269,703 - 170,349,616 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.04170,659,993 - 170,740,274 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4170,659,998 - 170,740,274 (-)Ensemblrn6Rnor6.0
Rnor_5.04234,917,953 - 234,998,564 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.44173,740,202 - 173,791,116 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera4158,151,931 - 158,232,578 (-)NCBICelera
RGSC_v3.14173,985,329 - 174,036,240 (-)NCBI
RH 3.4 Map41029.8RGD
Cytogenetic Map4q43NCBI
GUCY2C
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381214,612,632 - 14,696,599 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1214,612,632 - 14,696,599 (-)Ensemblhg38GRCh38
GRCh371214,765,566 - 14,849,533 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361214,656,843 - 14,740,696 (-)NCBIBuild 36Build 36hg18NCBI36
Build 341214,656,842 - 14,740,696NCBI
Celera1219,910,604 - 19,994,546 (-)NCBICelera
Cytogenetic Map12p12.3NCBI
HuRef1214,534,894 - 14,618,836 (-)NCBIHuRef
CHM1_11214,731,376 - 14,815,291 (-)NCBICHM1_1
T2T-CHM13v2.01214,490,079 - 14,574,057 (-)NCBIT2T-CHM13v2.0
Gucy2c
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm396136,674,282 - 136,758,740 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl6136,674,282 - 136,758,763 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm386136,697,284 - 136,781,742 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl6136,697,284 - 136,781,765 (-)Ensemblmm10GRCm38
MGSCv376136,645,805 - 136,730,263 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv366136,661,481 - 136,745,938 (-)NCBIMGSCv36mm8
Celera6139,693,560 - 139,778,559 (-)NCBICelera
Cytogenetic Map6G1NCBI
cM Map666.67NCBI
Gucy2c
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541311,410,586 - 11,489,201 (-)Ensembl
ChiLan1.0NW_00495541311,410,586 - 11,489,201 (-)NCBIChiLan1.0ChiLan1.0
GUCY2C
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21020,056,633 - 20,140,432 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11220,053,393 - 20,137,193 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01214,608,794 - 14,687,190 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11215,007,612 - 15,091,778 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1215,008,099 - 15,091,647 (-)EnsemblpanPan2panpan1.1
GUCY2C
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12731,915,552 - 31,989,748 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2731,917,604 - 31,989,551 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2714,459,047 - 14,531,591 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02732,224,305 - 32,296,840 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2732,224,094 - 32,296,857 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12732,113,413 - 32,186,004 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02732,072,317 - 32,144,886 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02714,190,563 - 14,263,769 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Gucy2c
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494593,015,174 - 93,083,797 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365872,742,911 - 2,810,969 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365872,742,911 - 2,811,139 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GUCY2C
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11114,534,787 - 14,668,746 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1114,534,883 - 14,613,255 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366606920,696,570 - 20,777,568 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Gucy2c
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475223,286,093 - 23,357,662 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462475223,285,987 - 23,357,662 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Gucy2c
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1612,683,005 - 12,760,992 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Gucy2c
438 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:77
Count of miRNA genes:67
Interacting mature miRNAs:73
Transcripts:ENSRNOT00000012212
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
6478754Anxrr43Anxiety related response QTL 430.14035locomotor behavior trait (VT:0001392)distance moved per unit of time into, out of or within a discrete space in an experimental apparatus (CMO:0001493)4146370897184426481Rat
724558Plsm2Polydactyly-luxate syndrome (PLS) morphotypes QTL 20.0003hindlimb integrity trait (VT:0010563)hind foot phalanges count (CMO:0001949)4134095016179095016Rat
6478757Anxrr44Anxiety related response QTL 440.01087locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4155834926184426481Rat
6478693Anxrr32Anxiety related response QTL 320.00092locomotor behavior trait (VT:0001392)measurement of voluntary locomotion into, out of or within a discrete space in an experimental apparatus (CMO:0000957)4146370897184426481Rat
1358364Sradr4Stress Responsive Adrenal Weight QTL 44.92adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)4131384565176384565Rat
1331738Bp209Blood pressure QTL 2092.979arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)4140059299181024663Rat
6478700Anxrr33Anxiety related response QTL 330.00896locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4146370897184426481Rat
1298524Oia8Oil induced arthritis QTL 8joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4140059299184426481Rat
10053718Scort25Serum corticosterone level QTL 252.150.0097blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)4157292416184426481Rat
738009Sach4Saccharine consumption QTL 44.90.000016consumption behavior trait (VT:0002069)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)460916264184426481Rat
7411558Bw133Body weight QTL 13313.840.001body mass (VT:0001259)body weight gain (CMO:0000420)4127263297172263297Rat
6478778Anxrr51Anxiety related response QTL 510.25384locomotor behavior trait (VT:0001392)measurement of voluntary locomotion into, out of or within a discrete space in an experimental apparatus (CMO:0000957)4126334185171334185Rat
10401796Kidm48Kidney mass QTL 48kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)4147299608184426481Rat
6478718Anxrr34Anxiety related response QTL 340.00896locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4146370897184426481Rat
6478782Anxrr52Anxiety related response QTL 520.02091locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4155834926184426481Rat
6478720Alc23Alcohol consumption QTL 230.00509drinking behavior trait (VT:0001422)ethanol drink intake rate to body weight ratio (CMO:0001616)4155834926184426481Rat
6478785Anxrr53Anxiety related response QTL 530.01397locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4155834926184426481Rat
738031Alc14Alcohol consumption QTL 147.60.00003consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)460916264174095838Rat
1576316Ept5Estrogen-induced pituitary tumorigenesis QTL 53.8pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)4100752691179366077Rat
1581566Eae21Experimental allergic encephalomyelitis QTL 216.2body mass (VT:0001259)maximum body weight loss to initial body weight ratio (CMO:0001400)4137447185182447185Rat
1578674Bmd12Bone mineral density QTL 123.8femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)4137430611182430611Rat
6478728Anxrr36Anxiety related response QTL 360.01061locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4155834926184426481Rat
738016Alc16Alcohol consumption QTL 163.60.00015consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)460916264184426481Rat
634342Cia24Collagen induced arthritis QTL 244.5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4148121375176967367Rat
6478733Anxrr37Anxiety related response QTL 370.00095locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4155834926184426481Rat
61362Oia2Oil induced arthritis QTL 20.001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4140059299184426481Rat
6478737Anxrr38Anxiety related response QTL 380.00159locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4155834926184426481Rat
2293659Bmd35Bone mineral density QTL 354.50.0001femur strength trait (VT:0010010)femoral neck ultimate force (CMO:0001703)4160623982184426481Rat
2316958Gluco58Glucose level QTL 5810blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)412212457182430611Rat
6478748Anxrr42Anxiety related response QTL 420.28008locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4146370897184426481Rat

Markers in Region
RH131297  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24169,568,533 - 169,568,721 (+)MAPPERmRatBN7.2
Rnor_6.04170,660,003 - 170,660,190NCBIRnor6.0
Rnor_5.04234,917,963 - 234,918,150UniSTSRnor5.0
RGSC_v3.44173,699,062 - 173,699,249UniSTSRGSC3.4
Celera4158,151,941 - 158,152,128UniSTS
Cytogenetic Map4q43UniSTS
RH94410  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24169,568,529 - 169,568,720 (+)MAPPERmRatBN7.2
Rnor_6.04170,659,999 - 170,660,189NCBIRnor6.0
Rnor_5.04234,917,959 - 234,918,149UniSTSRnor5.0
RGSC_v3.44173,699,063 - 173,699,253UniSTSRGSC3.4
Celera4158,151,937 - 158,152,127UniSTS
RH 3.4 Map41029.8UniSTS
Cytogenetic Map4q43UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 10 35 100 82 81 51 72 51 6 256 138 11 78 44 73 30 4 4

Sequence


Ensembl Acc Id: ENSRNOT00000012212   ⟹   ENSRNOP00000012212
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl4171,299,740 - 171,380,296 (-)Ensembl
mRatBN7.2 Ensembl4169,568,529 - 169,649,092 (-)Ensembl
Rnor_6.0 Ensembl4170,659,998 - 170,740,274 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000101883   ⟹   ENSRNOP00000091612
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl4171,299,740 - 171,380,296 (-)Ensembl
mRatBN7.2 Ensembl4169,568,529 - 169,649,092 (-)Ensembl
RefSeq Acc Id: NM_013170   ⟹   NP_037302
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84171,299,735 - 171,380,296 (-)NCBI
mRatBN7.24169,568,524 - 169,649,092 (-)NCBI
Rnor_6.04170,659,993 - 170,740,274 (-)NCBI
Rnor_5.04234,917,953 - 234,998,564 (-)NCBI
RGSC_v3.44173,740,202 - 173,791,116 (-)RGD
Celera4158,151,931 - 158,232,578 (-)RGD
Sequence:
RefSeq Acc Id: XM_039107137   ⟹   XP_038963065
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84171,299,715 - 171,378,146 (-)NCBI
mRatBN7.24169,568,505 - 169,649,004 (-)NCBI
RefSeq Acc Id: XM_039107138   ⟹   XP_038963066
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84171,299,715 - 171,358,224 (-)NCBI
mRatBN7.24169,568,505 - 169,627,019 (-)NCBI
RefSeq Acc Id: XM_063285634   ⟹   XP_063141704
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84171,299,715 - 171,378,146 (-)NCBI
RefSeq Acc Id: NP_037302   ⟸   NM_013170
- Peptide Label: precursor
- UniProtKB: P23897 (UniProtKB/Swiss-Prot),   A6IMI1 (UniProtKB/TrEMBL),   A0A8I6ACF0 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000012212   ⟸   ENSRNOT00000012212
RefSeq Acc Id: XP_038963065   ⟸   XM_039107137
- Peptide Label: isoform X2
- UniProtKB: A0A8I6ACF0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038963066   ⟸   XM_039107138
- Peptide Label: isoform X3
- UniProtKB: A6IMI3 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000091612   ⟸   ENSRNOT00000101883
RefSeq Acc Id: XP_063141704   ⟸   XM_063285634
- Peptide Label: isoform X1
- UniProtKB: A0A8I6ACF0 (UniProtKB/TrEMBL)
Protein Domains
Guanylate cyclase   Protein kinase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P23897-F1-model_v2 AlphaFold P23897 1-1072 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2771 AgrOrtholog
BioCyc Gene G2FUF-42599 BioCyc
Ensembl Genes ENSRNOG00000009031 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000012212 ENTREZGENE
  ENSRNOT00000012212.6 UniProtKB/Swiss-Prot
Gene3D-CATH 3.30.70.1230 UniProtKB/Swiss-Prot
  3.40.50.2300 UniProtKB/Swiss-Prot
  Transferase(Phosphotransferase) domain 1 UniProtKB/Swiss-Prot
InterPro A/G_cyclase UniProtKB/Swiss-Prot
  A/G_cyclase_CS UniProtKB/Swiss-Prot
  ANF_lig-bd_rcpt UniProtKB/Swiss-Prot
  Cyclic_nucleotide_synthase UniProtKB/Swiss-Prot
  Kinase-like_dom_sf UniProtKB/Swiss-Prot
  Nucleotide_cyclase UniProtKB/Swiss-Prot
  Peripla_BP_I UniProtKB/Swiss-Prot
  Prot_kinase_dom UniProtKB/Swiss-Prot
  Ser-Thr/Tyr_kinase_cat_dom UniProtKB/Swiss-Prot
KEGG Report rno:25711 UniProtKB/Swiss-Prot
NCBI Gene 25711 ENTREZGENE
PANTHER GUANYLYL CYCLASE UniProtKB/Swiss-Prot
  HEAT-STABLE ENTEROTOXIN RECEPTOR UniProtKB/Swiss-Prot
Pfam ANF_receptor UniProtKB/Swiss-Prot
  Guanylate_cyc UniProtKB/Swiss-Prot
  Pkinase_Tyr UniProtKB/Swiss-Prot
PhenoGen Gucy2c PhenoGen
PROSITE GUANYLATE_CYCLASE_1 UniProtKB/Swiss-Prot
  GUANYLATE_CYCLASE_2 UniProtKB/Swiss-Prot
  PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000009031 RatGTEx
SMART CYCc UniProtKB/Swiss-Prot
Superfamily-SCOP SSF53822 UniProtKB/Swiss-Prot
  SSF55073 UniProtKB/Swiss-Prot
  SSF56112 UniProtKB/Swiss-Prot
TIGR TC212481
UniProt A0A8I6ACF0 ENTREZGENE, UniProtKB/TrEMBL
  A6IMI1 ENTREZGENE, UniProtKB/TrEMBL
  A6IMI3 ENTREZGENE, UniProtKB/TrEMBL
  GUC2C_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-04-12 Gucy2c  guanylate cyclase 2C  LOC100359629  guanylate cyclase 2c  Data merged from RGD:2325098 737654 PROVISIONAL
2010-05-20 LOC100359629  guanylate cyclase 2c      Symbol and Name status set to provisional 70820 PROVISIONAL
2003-04-09 Gucy2c  guanylate cyclase 2C    Guanylate cyclase 2C (heat stable enterotoxin receptor)  Name updated 629478 APPROVED
2002-06-10 Gucy2c  Guanylate cyclase 2C (heat stable enterotoxin receptor)      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_domains contains intracellular protein kinase-like and cyclase catalytic domains 728418