Glra1 (glycine receptor, alpha 1) - Rat Genome Database

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Gene: Glra1 (glycine receptor, alpha 1) Rattus norvegicus
Analyze
Symbol: Glra1
Name: glycine receptor, alpha 1
RGD ID: 2704
Description: Enables extracellularly glycine-gated chloride channel activity; glycine binding activity; and identical protein binding activity. Involved in chloride transport and glycinergic synaptic transmission. Located in endoplasmic reticulum and external side of plasma membrane. Is active in calyx of Held; glycinergic synapse; and synaptic membrane. Human ortholog(s) of this gene implicated in hyperekplexia 1. Orthologous to human GLRA1 (glycine receptor alpha 1); PARTICIPATES IN Inhibitory synaptic transmission pathway; INTERACTS WITH 2,3,7,8-Tetrachlorodibenzofuran; 6-propyl-2-thiouracil; atrazine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: glycine receptor 48 kDa subunit; glycine receptor strychnine-binding subunit; glycine receptor subunit alpha-1; glycine receptor, alpha 1 subunit; GLYRA1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81040,128,284 - 40,228,612 (-)NCBIGRCr8
mRatBN7.21039,625,853 - 39,727,897 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1039,629,459 - 39,727,162 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1044,313,228 - 44,411,116 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01043,803,339 - 43,901,228 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01039,307,010 - 39,404,890 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01040,851,955 - 40,954,364 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1040,855,559 - 40,953,651 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01040,687,069 - 40,785,100 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41040,922,867 - 41,021,767 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11040,936,489 - 41,035,390 (-)NCBI
Celera1038,958,969 - 39,055,009 (-)NCBICelera
Cytogenetic Map10q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Object Symbol
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Original Reference(s)
Glra1Ratepilepsy  ISOGLRA1 (Homo sapiens)8554872ClinVar Annotator: match by term: SeizureClinVarPMID:25741868 and PMID:28492532
Glra1Ratfamilial adenomatous polyposis 1  ISOGLRA1 (Homo sapiens)8554872ClinVar Annotator: match by term: Familial adenomatous polyposis 1ClinVarPMID:17963004 more ...
Glra1Ratgenetic disease  ISOGLRA1 (Homo sapiens)8554872ClinVar Annotator: match by term: Inborn genetic diseasesClinVarPMID:11389164 more ...
Glra1RatHereditary Neoplastic Syndromes  ISOGLRA1 (Homo sapiens)8554872ClinVar Annotator: match by term: Hereditary cancer-predisposing syndromeClinVarPMID:17963004 more ...
Glra1Rathyperekplexia  ISOGLRA1 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:10817489 more ...
Glra1Rathyperekplexia 1  ISOGLRA1 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:10817489 more ...
Glra1RatStiff-Person syndrome  ISOGLRA1 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:10514101 more ...
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Original Reference(s)
Glra1Ratdystonia  ISOGLRA1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:17114051
Glra1RatStiff-Person syndrome  ISOGLRA1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:9927632 and PMID:18175347
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Original Reference(s)
Glra1Rathyperekplexia  ISSGlra1 (Mus musculus)13592920 MouseDO 
Glra1Rathyperekplexia 1  ISSGlra1 (Mus musculus)13592920OMIM:149400MouseDO 
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Original Reference(s)
Glra1Rathyperekplexia 1  ISOGLRA1 (Homo sapiens)7240710 OMIM 

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Glra1Rat1,1,1-trichloroethane multiple interactionsISOGLRA1 (Homo sapiens)64804641 more ...CTDPMID:10825391
Glra1Rat1,1,1-trichloroethane increases response to substanceISOGLRA1 (Homo sapiens)6480464GLRA1 protein results in increased susceptibility to 1 more ...CTDPMID:10825391
Glra1Rat2,2,2-trifluoroethanol multiple interactionsISOGLRA1 (Homo sapiens)6480464Trifluoroethanol promotes the reaction [Glycine Agents results in increased activity of GLRA1 protein]CTDPMID:10683198
Glra1Rat2,3,7,8-tetrachlorodibenzodioxine affects expressionISOGlra1 (Mus musculus)6480464Tetrachlorodibenzodioxin affects the expression of GLRA1 mRNACTDPMID:21570461
Glra1Rat2,3,7,8-Tetrachlorodibenzofuran decreases expressionEXP 64804642 more ...CTDPMID:32109520
Glra1Rat4,4'-diaminodiphenylmethane increases expressionISOGlra1 (Mus musculus)64804644 and 4'-diaminodiphenylmethane results in increased expression of GLRA1 mRNACTDPMID:18648102
Glra1Rat6-propyl-2-thiouracil decreases expressionEXP 6480464Propylthiouracil results in decreased expression of GLRA1 mRNACTDPMID:24780913
Glra1Ratacetaldehyde increases activityISOGLRA1 (Homo sapiens)6480464Acetaldehyde results in increased activity of GLRA1 proteinCTDPMID:11707631
Glra1Rataflatoxin B1 decreases methylationISOGLRA1 (Homo sapiens)6480464Aflatoxin B1 results in decreased methylation of GLRA1 geneCTDPMID:27153756
Glra1Rataristolochic acid A increases expressionISOGLRA1 (Homo sapiens)6480464aristolochic acid I results in increased expression of GLRA1 mRNACTDPMID:33212167
Glra1Ratarsenite(3-) increases methylationISOGLRA1 (Homo sapiens)6480464arsenite results in increased methylation of GLRA1 promoterCTDPMID:23974009
Glra1Ratatrazine affects methylationEXP 6480464Atrazine affects the methylation of GLRA1 geneCTDPMID:35440735
Glra1Ratatropine multiple interactionsISOGLRA1 (Homo sapiens)6480464Atropine binds to and results in decreased activity of GLRA1 proteinCTDPMID:15081878
Glra1Ratbenzo[a]pyrene affects methylationISOGLRA1 (Homo sapiens)6480464Benzo(a)pyrene affects the methylation of GLRA1 exon and Benzo(a)pyrene affects the methylation of GLRA1 promoterCTDPMID:27901495
Glra1Ratbis(2-ethylhexyl) phthalate decreases expressionISOGLRA1 (Homo sapiens)6480464Diethylhexyl Phthalate results in decreased expression of GLRA1 mRNACTDPMID:31163220
Glra1Ratbisphenol A decreases expressionEXP 6480464bisphenol A results in decreased expression of GLRA1 mRNACTDPMID:25181051
Glra1Ratbisphenol A increases methylationEXP 6480464bisphenol A results in increased methylation of GLRA1 geneCTDPMID:28505145
Glra1Ratbisphenol F multiple interactionsISOGLRA1 (Homo sapiens)6480464[bisphenol F co-treated with Fulvestrant] results in increased methylation of GLRA1 geneCTDPMID:31601247
Glra1Ratbrucine multiple interactionsISOGLRA1 (Homo sapiens)6480464brucine analog binds to and results in decreased activity of GLRA1 protein and brucine binds to and results in decreased activity of GLRA1 proteinCTDPMID:15081878 and PMID:16687139
Glra1Ratbutanethiol multiple interactionsISOGLRA1 (Homo sapiens)6480464n-butyl mercaptan promotes the reaction [Glycine Agents binds to and results in decreased activity of GLRA1 protein]CTDPMID:11049924

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Biological Process
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Glra1Ratacrosome reaction acts_upstream_of_or_withinISOGlra1 (Mus musculus)1624291MGI:1856362 PMID:11076688RGDPMID:11076688
Glra1Ratacrosome reaction acts_upstream_of_or_withinIEAUniProtKB:Q64018 and ensembl:ENSMUSP000000750321600115GO_REF:0000107EnsemblGO_REF:0000107
Glra1Ratadult walking behavior acts_upstream_of_or_withinISOGlra1 (Mus musculus)1624291MGI:3696673 PMID:17114051RGDPMID:17114051
Glra1Ratadult walking behavior acts_upstream_of_or_withinIEAUniProtKB:Q64018 and ensembl:ENSMUSP000000750321600115GO_REF:0000107EnsemblGO_REF:0000107
Glra1Ratcellular response to amino acid stimulus involved_inIEAUniProtKB:P23415 and ensembl:ENSP000002745761600115GO_REF:0000107EnsemblGO_REF:0000107
Glra1Ratcellular response to amino acid stimulus involved_inISOGLRA1 (Homo sapiens)1624291 PMID:16144831RGDPMID:16144831
Glra1Ratcellular response to amino acid stimulus involved_inISSUniProtKB:P234151600115GO_REF:0000024UniProtGO_REF:0000024
Glra1Ratcellular response to ethanol involved_inIEAUniProtKB:P23415 and ensembl:ENSP000002745761600115GO_REF:0000107EnsemblGO_REF:0000107
Glra1Ratcellular response to ethanol involved_inISOGLRA1 (Homo sapiens)1624291 PMID:25973519RGDPMID:25973519
Glra1Ratcellular response to ethanol involved_inISSUniProtKB:P234151600115GO_REF:0000024UniProtGO_REF:0000024
Glra1Ratcellular response to zinc ion involved_inISSUniProtKB:P234151600115GO_REF:0000024UniProtGO_REF:0000024
Glra1Ratcellular response to zinc ion involved_inIEAUniProtKB:P23415 and ensembl:ENSP000002745761600115GO_REF:0000107EnsemblGO_REF:0000107
Glra1Ratcellular response to zinc ion involved_inISOGLRA1 (Homo sapiens)1624291 PMID:16144831RGDPMID:16144831
Glra1Ratchemical synaptic transmission acts_upstream_of_or_withinISOGlra1 (Mus musculus)1624291MGI:1856177 more ...RGDPMID:12837931
Glra1Ratchemical synaptic transmission acts_upstream_of_or_withinIEAUniProtKB:Q64018 and ensembl:ENSMUSP000000750321600115GO_REF:0000107EnsemblGO_REF:0000107
Glra1Ratchloride transmembrane transport involved_inIEAUniProtKB:P23415 and ensembl:ENSP000002745761600115GO_REF:0000107EnsemblGO_REF:0000107
Glra1Ratchloride transmembrane transport involved_inIBAFB:FBgn0033558 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Glra1Ratchloride transmembrane transport involved_inIEAGO:00052541600115GO_REF:0000108GOCGO_REF:0000108
Glra1Ratchloride transmembrane transport involved_inIEAGO:00169341600115GO_REF:0000108GOCGO_REF:0000108
Glra1Ratchloride transmembrane transport involved_inISOGLRA1 (Homo sapiens)1624291 PMID:16144831RGDPMID:16144831
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Cellular Component
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Original Reference(s)
Glra1Ratcalyx of Held is_active_inIDA 13702302PMID:23175852SynGO 
Glra1Ratcell projection located_inIEAUniProtKB-KW:KW-09661600115GO_REF:0000043UniProtGO_REF:0000043
Glra1Ratchloride channel complex part_ofIEAUniProtKB-KW:KW-08691600115GO_REF:0000043UniProtGO_REF:0000043
Glra1Ratdendrite located_inIEAUniProtKB-SubCell:SL-02831600115GO_REF:0000044UniProtGO_REF:0000044
Glra1Ratendoplasmic reticulum located_inIDA 8554660PMID:17145751MGI 
Glra1Ratexternal side of plasma membrane located_inIDA 8554660PMID:17145751MGI 
Glra1Ratexternal side of plasma membrane located_inISOGlra1 (Mus musculus)1624291 PMID:17145751RGDPMID:17145751
Glra1Ratexternal side of plasma membrane located_inIEAUniProtKB:Q64018 and ensembl:ENSMUSP000000750321600115GO_REF:0000107EnsemblGO_REF:0000107
Glra1Ratglycinergic synapse is_active_inIDA 13702401PMID:25339867SynGO 
Glra1Ratglycinergic synapse is_active_inISOGlra1 (Mus musculus)1624291 PMID:28724750RGDPMID:28724750
Glra1Ratglycinergic synapse is_active_inIEAUniProtKB:Q64018 and ensembl:ENSMUSP000000750321600115GO_REF:0000107EnsemblGO_REF:0000107
Glra1Ratinhibitory synapse located_inIEAUniProtKB:Q64018 and ensembl:ENSMUSP000000750321600115GO_REF:0000107EnsemblGO_REF:0000107
Glra1Ratinhibitory synapse located_inISOGlra1 (Mus musculus)1624291 PMID:9812897RGDPMID:9812897
Glra1Ratintracellular membrane-bounded organelle located_inIEAUniProtKB:P23415 and ensembl:ENSP000002745761600115GO_REF:0000107EnsemblGO_REF:0000107
Glra1Ratintracellular membrane-bounded organelle located_inISSUniProtKB:P234158553668PMID:2155780UniProt 
Glra1Ratintracellular membrane-bounded organelle located_inISOGLRA1 (Homo sapiens) more ...1624291 RGDGO_REF:0000052
Glra1Ratintracellular membrane-bounded organelle located_inISOGLRA1 (Homo sapiens)1624291 PMID:7506679RGDPMID:7506679
Glra1Ratmembrane located_inIDA 8554660PMID:17145751MGI 
Glra1Ratmembrane located_inISOGlra1 (Mus musculus)1624291 PMID:1371219 more ...RGDPMID:1371219 more ...
Glra1Ratmembrane located_inIEAUniProtKB-KW:KW-04721600115GO_REF:0000043UniProtGO_REF:0000043
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Molecular Function
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Original Reference(s)
Glra1Ratchloride channel activity enablesIEAUniProtKB-KW:KW-08691600115GO_REF:0000043UniProtGO_REF:0000043
Glra1Ratchloride channel activity contributes_toIBAPANTHER:PTN001055382 and UniProtKB:P481671600115GO_REF:0000033GO_CentralGO_REF:0000033
Glra1Ratextracellular ligand-gated monoatomic ion channel activity enablesIEAInterPro:IPR006202 and InterPro:IPR0367341600115GO_REF:0000002InterProGO_REF:0000002
Glra1Ratextracellularly glycine-gated chloride channel activity enablesIEAUniProtKB:P23415 and ensembl:ENSP000002745761600115GO_REF:0000107EnsemblGO_REF:0000107
Glra1Ratextracellularly glycine-gated chloride channel activity  IDA 625689 RGD 
Glra1Ratextracellularly glycine-gated chloride channel activity enablesISOGlra1 (Mus musculus)1624291MGI:1856177 more ...RGDPMID:16672662 more ...
Glra1Ratextracellularly glycine-gated chloride channel activity enablesIEAUniProtKB:Q64018 and ensembl:ENSMUSP000000750321600115GO_REF:0000107EnsemblGO_REF:0000107
Glra1Ratextracellularly glycine-gated chloride channel activity enablesISSUniProtKB:P234158553668PMID:2155780UniProt 
Glra1Ratextracellularly glycine-gated chloride channel activity enablesIEAInterPro:IPR0081281600115GO_REF:0000002InterProGO_REF:0000002
Glra1Ratextracellularly glycine-gated chloride channel activity enablesISOGLRA1 (Homo sapiens)1624291 PMID:16144831 more ...RGDPMID:16144831 more ...
Glra1Ratextracellularly glycine-gated ion channel activity  IDA 1598572 RGD 
Glra1Ratglycine binding  IDA 1598572 RGD 
Glra1Ratglycine binding enablesISOGlra1 (Mus musculus)1624291MGI:1856177 more ...RGDPMID:7874121 more ...
Glra1Ratglycine binding enablesIEAUniProtKB:P23415 and ensembl:ENSP000002745761600115GO_REF:0000107EnsemblGO_REF:0000107
Glra1Ratglycine binding enablesIEAUniProtKB:Q64018 and ensembl:ENSMUSP000000750321600115GO_REF:0000107EnsemblGO_REF:0000107
Glra1Ratglycine binding enablesISSUniProtKB:P234158553668PMID:2155780UniProt 
Glra1Ratglycine binding enablesIEAInterPro:IPR0081271600115GO_REF:0000002InterProGO_REF:0000002
Glra1Ratglycine binding enablesISOGLRA1 (Homo sapiens)1624291 PMID:15748848 more ...RGDPMID:15748848 more ...
Glra1Ratidentical protein binding  IPIGlra1 (Rattus norvegicus)1598573homooligomerizationRGD 
Glra1Ratidentical protein binding enablesISOGLRA1 (Homo sapiens) and UniProtKB:P23415-11624291UniProtKB:P23415-1 and PMID:23994010RGDPMID:23994010
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RGD Manual Annotations


  
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Original Reference(s)
Glra1RatInhibitory synaptic transmission pathway  IDA 1598573 RGD 

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Reference Title
Reference Citation
1. Functional properties of strychnine-sensitive glycine receptors expressed in Xenopus oocytes injected with a single mRNA. Akagi H, etal., Neurosci Res 1991 Jun;11(1):28-40.
2. Openings of the rat recombinant alpha 1 homomeric glycine receptor as a function of the number of agonist molecules bound. Beato M, etal., J Gen Physiol 2002 May;119(5):443-66.
3. The activation mechanism of alpha1 homomeric glycine receptors. Beato M, etal., J Neurosci. 2004 Jan 28;24(4):895-906.
4. Single-channel behavior of heteromeric alpha1beta glycine receptors: an attempt to detect a conformational change before the channel opens. Burzomato V, etal., J Neurosci. 2004 Dec 1;24(48):10924-40.
5. Molecular evidence for a glycine-gated chloride channel in macrophages and leukocytes. Froh M, etal., Am J Physiol Gastrointest Liver Physiol 2002 Oct;283(4):G856-63.
6. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
7. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
8. Alpha subunit variants of the human glycine receptor: primary structures, functional expression and chromosomal localization of the corresponding genes. Grenningloh G, etal., EMBO J. 1990 Mar;9(3):771-6.
9. The strychnine-binding subunit of the glycine receptor shows homology with nicotinic acetylcholine receptors. Grenningloh G, etal., Nature 1987 Jul 16-22;328(6127):215-20.
10. Differential distribution of glycine receptor subtypes at the rat calyx of Held synapse. Hruskova B, etal., J Neurosci. 2012 Nov 21;32(47):17012-24. doi: 10.1523/JNEUROSCI.1547-12.2012.
11. Alternative splicing generates two variants of the alpha 1 subunit of the inhibitory glycine receptor. Malosio ML, etal., J Biol Chem 1991 Feb 5;266(4):2048-53.
12. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
13. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
14. A novel glycine receptor beta subunit splice variant predicts an unorthodox transmembrane topology. Assembly into heteromeric receptor complexes. Oertel J, etal., J Biol Chem. 2007 Feb 2;282(5):2798-807. Epub 2006 Dec 4.
15. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
16. Online Mendelian Inheritance in Man, OMIM (TM). Online Mendelian Inheritance in Man, OMIM (TM).
17. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
18. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
19. Distribution of glycine receptors on the surface of the mature calyx of Held nerve terminal. Trojanova J, etal., Front Neural Circuits. 2014 Oct 6;8:120. doi: 10.3389/fncir.2014.00120. eCollection 2014.
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PMID:1371219   PMID:2171639   PMID:2483325   PMID:7506679   PMID:7874121   PMID:7920629   PMID:8062927   PMID:8137830   PMID:8298642   PMID:8406478   PMID:8717357   PMID:8733750  
PMID:9087981   PMID:9145798   PMID:9812897   PMID:11076688   PMID:11275284   PMID:11742725   PMID:11751269   PMID:11973623   PMID:12380014   PMID:12457249   PMID:12837931   PMID:14698963  
PMID:15629462   PMID:15748848   PMID:16144831   PMID:16672662   PMID:16800867   PMID:16964444   PMID:17114051   PMID:17331994   PMID:21917927   PMID:22006921   PMID:22018691   PMID:23994010  
PMID:24198360   PMID:24801766   PMID:25236484   PMID:25339760   PMID:25973519   PMID:27226610   PMID:28026001   PMID:28724750   PMID:34802146   PMID:38017313  



Glra1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81040,128,284 - 40,228,612 (-)NCBIGRCr8
mRatBN7.21039,625,853 - 39,727,897 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1039,629,459 - 39,727,162 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1044,313,228 - 44,411,116 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01043,803,339 - 43,901,228 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01039,307,010 - 39,404,890 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01040,851,955 - 40,954,364 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1040,855,559 - 40,953,651 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01040,687,069 - 40,785,100 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41040,922,867 - 41,021,767 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11040,936,489 - 41,035,390 (-)NCBI
Celera1038,958,969 - 39,055,009 (-)NCBICelera
Cytogenetic Map10q22NCBI
GLRA1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385151,822,513 - 151,924,851 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl5151,822,513 - 151,924,851 (-)EnsemblGRCh38hg38GRCh38
GRCh375151,202,074 - 151,304,412 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 365151,182,361 - 151,284,596 (-)NCBINCBI36Build 36hg18NCBI36
Build 345151,182,360 - 151,284,596NCBI
Celera5147,283,467 - 147,385,844 (-)NCBICelera
Cytogenetic Map5q33.1NCBI
HuRef5146,347,483 - 146,449,349 (-)NCBIHuRef
CHM1_15150,634,496 - 150,736,836 (-)NCBICHM1_1
T2T-CHM13v2.05152,361,497 - 152,463,867 (-)NCBIT2T-CHM13v2.0
Glra1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391155,405,065 - 55,499,024 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1155,405,064 - 55,499,024 (-)EnsemblGRCm39 Ensembl
GRCm381155,514,239 - 55,608,198 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1155,514,238 - 55,608,198 (-)EnsemblGRCm38mm10GRCm38
MGSCv371155,328,315 - 55,421,292 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361155,358,236 - 55,451,213 (-)NCBIMGSCv36mm8
Celera1160,300,816 - 60,360,053 (-)NCBICelera
Cytogenetic Map11B1.3NCBI
cM Map1133.12NCBI
Glra1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554086,236,092 - 6,333,166 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554086,236,092 - 6,333,166 (-)NCBIChiLan1.0ChiLan1.0
GLRA1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v24147,050,625 - 147,153,444 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan15145,190,265 - 145,292,989 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v05147,245,741 - 147,348,555 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.15153,248,488 - 153,350,573 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl5153,248,488 - 153,350,567 (-)Ensemblpanpan1.1panPan2
GLRA1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1457,443,094 - 57,541,494 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl457,443,999 - 57,528,376 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha457,296,776 - 57,348,297 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0457,919,593 - 57,971,180 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl457,885,421 - 57,971,013 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1457,735,798 - 57,787,335 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0457,834,258 - 57,885,784 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0458,337,576 - 58,389,066 (+)NCBIUU_Cfam_GSD_1.0
Glra1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213112,367,383 - 112,460,891 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493651510,817,422 - 10,896,958 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493651510,816,712 - 10,896,958 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GLRA1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1671,142,198 - 71,230,344 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11671,140,751 - 71,236,867 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21677,317,685 - 77,407,159 (+)NCBISscrofa10.2Sscrofa10.2susScr3
GLRA1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12354,384,452 - 54,485,957 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2354,387,229 - 54,484,372 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603423,216,388 - 23,318,088 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Glra1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473337,153,863 - 37,235,485 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473337,153,348 - 37,238,201 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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Variants in Glra1
858 total Variants

Predicted Target Of
Summary Value
Count of predictions:182
Count of miRNA genes:137
Interacting mature miRNAs:158
Transcripts:ENSRNOT00000063889
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 55 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
61441Btemp1Thermal response to stress QTL 14body temperature trait (VT:0005535)core body temperature (CMO:0001036)103539245763642539Rat
9589136Insul27Insulin level QTL 2710.460.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)101147401056474010Rat
152025229Scl83Serum cholesterol level QTL 834.33blood cholesterol amount (VT:0000180)103571058068663659Rat
1578779Tcas10Tongue tumor susceptibility QTL 103.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)103129743976297439Rat
631564Apr3Acute phase response QTL 33.9blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)101527595560275955Rat
1298069Bp168Blood pressure QTL 1685.5blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)102652195798003205Rat
631554Bp133Blood pressure QTL 1330.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1074336463851208Rat
631557Bp136Blood pressure QTL 1360.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)103063205375632053Rat
61325Aia5Adjuvant induced arthritis QTL 50.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
1578761Stresp21Stress response QTL 213.3thymus mass (VT:0004954)thymus wet weight (CMO:0000855)10637574651375746Rat

1 to 10 of 55 rows



alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
hemolymphoid system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
8 8 74 10 23 1 1 19 10 72 1 44 23



Ensembl Acc Id: ENSRNOT00000063889   ⟹   ENSRNOP00000063384
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1039,629,459 - 39,727,162 (-)Ensembl
Rnor_6.0 Ensembl1040,855,559 - 40,953,651 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000092189   ⟹   ENSRNOP00000073440
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1039,630,050 - 39,726,978 (-)Ensembl
Rnor_6.0 Ensembl1040,856,150 - 40,953,467 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000113718   ⟹   ENSRNOP00000088166
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1039,630,050 - 39,694,990 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000119787   ⟹   ENSRNOP00000087752
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1039,630,050 - 39,695,038 (-)Ensembl
RefSeq Acc Id: NM_013133   ⟹   NP_037265
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81040,130,121 - 40,227,815 (-)NCBI
mRatBN7.21039,629,459 - 39,727,162 (-)NCBI
Rnor_6.01040,855,559 - 40,953,651 (-)NCBI
Rnor_5.01040,687,069 - 40,785,100 (-)NCBI
RGSC_v3.41040,922,867 - 41,021,767 (-)RGD
Celera1038,958,969 - 39,055,009 (-)RGD
Sequence:
RefSeq Acc Id: XM_006246378   ⟹   XP_006246440
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81040,128,284 - 40,228,612 (-)NCBI
mRatBN7.21039,625,853 - 39,727,897 (-)NCBI
Rnor_6.01040,851,955 - 40,954,364 (-)NCBI
Rnor_5.01040,687,069 - 40,785,100 (-)NCBI
Sequence:
RefSeq Acc Id: NP_037265   ⟸   NM_013133
- Peptide Label: precursor
- UniProtKB: Q546L7 (UniProtKB/TrEMBL),   A0A096MIV2 (UniProtKB/TrEMBL),   A0A8I6GGT5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006246440   ⟸   XM_006246378
- Peptide Label: isoform X1
- UniProtKB: Q546L6 (UniProtKB/Swiss-Prot),   P07727 (UniProtKB/Swiss-Prot),   A6HEN3 (UniProtKB/TrEMBL),   A0A8I6GGT5 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000073440   ⟸   ENSRNOT00000092189
Ensembl Acc Id: ENSRNOP00000063384   ⟸   ENSRNOT00000063889
Ensembl Acc Id: ENSRNOP00000088166   ⟸   ENSRNOT00000113718
Neurotransmitter-gated ion-channel ligand-binding   Neurotransmitter-gated ion-channel transmembrane

Name Modeler Protein Id AA Range Protein Structure
AF-P07727-F1-model_v2 AlphaFold P07727 1-457 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen



1 to 40 of 40 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-25074 BioCyc
Ensembl Genes ENSRNOG00000013588 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000063889 ENTREZGENE
  ENSRNOT00000063889.4 UniProtKB/Swiss-Prot
Gene3D-CATH 1.20.58.390 UniProtKB/Swiss-Prot
  2.70.170.10 UniProtKB/Swiss-Prot
InterPro GABAA/Glycine_rcpt UniProtKB/Swiss-Prot
  Glycine_rcpt_A UniProtKB/Swiss-Prot
  Glycine_rcpt_A1 UniProtKB/Swiss-Prot
  Neur_chan_lig-bd UniProtKB/Swiss-Prot
  Neur_chan_lig-bd_sf UniProtKB/Swiss-Prot
  Neur_channel UniProtKB/Swiss-Prot
  Neuro-gated_channel_TM_sf UniProtKB/Swiss-Prot
  Neuro_actylchol_rec UniProtKB/Swiss-Prot
  Neurotrans-gated_channel_TM UniProtKB/Swiss-Prot
  Neurotransmitter_ion_chnl_CS UniProtKB/Swiss-Prot
KEGG Report rno:25674 UniProtKB/Swiss-Prot
NCBI Gene 25674 ENTREZGENE
PANTHER PTHR18945 UniProtKB/Swiss-Prot
Pfam Neur_chan_LBD UniProtKB/Swiss-Prot
  Neur_chan_memb UniProtKB/Swiss-Prot
PhenoGen Glra1 PhenoGen
PRINTS GABAARECEPTR UniProtKB/Swiss-Prot
  GLYRALPHA UniProtKB/Swiss-Prot
  GLYRALPHA1 UniProtKB/Swiss-Prot
  NRIONCHANNEL UniProtKB/Swiss-Prot
PROSITE NEUROTR_ION_CHANNEL UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000013588 RatGTEx
Superfamily-SCOP SSF63712 UniProtKB/Swiss-Prot
  SSF90112 UniProtKB/Swiss-Prot
UniProt A0A096MIV2 ENTREZGENE
  A0A8I6A8K2_RAT UniProtKB/TrEMBL
  A0A8I6GGT5 ENTREZGENE, UniProtKB/TrEMBL
  A6HEN3 ENTREZGENE, UniProtKB/TrEMBL
  A6HEN4_RAT UniProtKB/TrEMBL
  GLRA1_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q546L6 ENTREZGENE
  Q546L7 ENTREZGENE, UniProtKB/TrEMBL
  Q99JD0_RAT UniProtKB/TrEMBL
UniProt Secondary Q546L6 UniProtKB/Swiss-Prot
1 to 40 of 40 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-11-14 Glra1  glycine receptor, alpha 1  Glra1  glycine receptor, alpha 1 subunit  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Glra1  Glycine receptor, alpha 1 subunit      Symbol and Name status set to approved 70586 APPROVED

Note Type Note Reference
gene_expression mRNA and protein expressed in Kupffer cells, other macrophages and leukocytes 625689
gene_protein 48 kDa 625689