Gja5 (gap junction protein, alpha 5) - Rat Genome Database

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Gene: Gja5 (gap junction protein, alpha 5) Rattus norvegicus
Analyze
Symbol: Gja5
Name: gap junction protein, alpha 5
RGD ID: 2692
Description: Enables connexin binding activity; disordered domain specific binding activity; and gap junction channel activity. Involved in several processes, including blood vessel diameter maintenance; cell communication by chemical coupling; and regulation of blood pressure. Located in cell projection. Part of connexin complex. Used to study hypertension. Biomarker of artery disease (multiple); glomerulonephritis; obesity; overactive bladder syndrome; and ureteral obstruction. Human ortholog(s) of this gene implicated in atrial fibrillation; atrial standstill 1; familial atrial fibrillation; and tetralogy of Fallot. Orthologous to human GJA5 (gap junction protein alpha 5); PARTICIPATES IN connexin signaling pathway; INTERACTS WITH 6-propyl-2-thiouracil; acadesine; all-trans-retinoic acid.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: connexin 40; connexin i; connexin-40; Cx40; Cxni; gap junction alpha-5 protein; gap junction membrane channel protein alpha 5; gap junction membrane channel protein alpha 5 (connexin 40)
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: Gja5em1Mcwi  
Genetic Models: WKY-Gja5em1Mcwi
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82187,291,227 - 187,310,770 (+)NCBIGRCr8
mRatBN7.22184,602,407 - 184,621,952 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2184,564,475 - 184,621,952 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2192,244,465 - 192,263,988 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02190,042,684 - 190,062,193 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02184,877,034 - 184,896,564 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02199,162,745 - 199,184,942 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2199,162,745 - 199,184,939 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02218,648,368 - 218,669,354 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42191,824,118 - 191,843,867 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12191,786,871 - 191,806,619 (+)NCBI
Celera2177,098,223 - 177,117,685 (+)NCBICelera
Cytogenetic Map2q34NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
angiogenesis  (ISO)
artery morphogenesis  (ISO)
atrial cardiac muscle cell to AV node cell communication by electrical coupling  (IBA,ISO)
atrial septum development  (ISO)
atrial septum morphogenesis  (ISO)
atrial ventricular junction remodeling  (ISO)
AV node cell to bundle of His cell communication  (ISO)
AV node cell to bundle of His cell communication by electrical coupling  (ISO)
blood vessel development  (ISO)
blood vessel diameter maintenance  (ISO)
bundle of His cell to Purkinje myocyte communication by electrical coupling  (ISO)
cardiac conduction  (ISO)
cardiac conduction system development  (ISO)
cell communication by chemical coupling  (IDA)
cell communication by electrical coupling  (IDA)
cell communication by electrical coupling involved in cardiac conduction  (ISO)
cell communication involved in cardiac conduction  (ISO)
cell-cell signaling  (IBA)
cellular response to platelet-derived growth factor stimulus  (ISO)
embryonic heart tube development  (ISO)
embryonic limb morphogenesis  (ISO)
endothelium development  (IEP)
foramen ovale closure  (ISO)
gap junction assembly  (ISO)
heart development  (IBA,IEP)
mitral valve development  (ISO)
negative regulation of blood pressure  (IMP)
negative regulation of glomerular filtration  (IMP)
outflow tract morphogenesis  (ISO)
positive regulation of cell communication by chemical coupling  (IMP)
positive regulation of vasoconstriction  (IMP)
potassium ion transport  (IDA)
pulmonary valve formation  (ISO)
regulation of atrial cardiac muscle cell action potential  (ISO)
regulation of atrial cardiac muscle cell membrane depolarization  (ISO)
regulation of AV node cell action potential  (ISO)
regulation of bundle of His cell action potential  (ISO)
regulation of cardiac muscle contraction  (ISO)
regulation of cell communication by electrical coupling  (IDA)
regulation of heart rate by cardiac conduction  (ISO)
regulation of membrane depolarization during cardiac muscle cell action potential  (ISO)
regulation of Purkinje myocyte action potential  (ISO)
regulation of renin secretion into blood stream  (ISO)
regulation of systemic arterial blood pressure  (ISO)
regulation of ventricular cardiac muscle cell membrane depolarization  (ISO)
regulation of ventricular cardiac muscle cell membrane repolarization  (ISO)
renal system process involved in regulation of systemic arterial blood pressure  (ISO)
SA node cell action potential  (ISO)
septum primum development  (ISO)
skeletal system development  (ISO)
transmembrane transport  (IEA)
vasodilation  (IMP)
vasomotion  (IMP)
ventricular cardiac muscle cell action potential  (ISO)
ventricular septum development  (ISO)
ventricular septum morphogenesis  (ISO)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Cerebrovascular connexin expression: effects of traumatic brain injury. Avila MA, etal., J Neurotrauma. 2011 Sep;28(9):1803-11. doi: 10.1089/neu.2011.1900. Epub 2011 Sep 6.
2. Unique conductance, gating, and selective permeability properties of gap junction channels formed by connexin40. Beblo DA, etal., Circ Res. 1995 Oct;77(4):813-22.
3. Molecular cloning and expression of rat connexin40, a gap junction protein expressed in vascular smooth muscle. Beyer EC, etal., J Membr Biol 1992 Apr;127(1):69-76.
4. Role of the gap junctions in the contractile response to agonists in pulmonary artery from two rat models of pulmonary hypertension. Billaud M, etal., Respir Res. 2011 Mar 17;12:30. doi: 10.1186/1465-9921-12-30.
5. Characterization of the structure and intermolecular interactions between the connexin40 and connexin43 carboxyl-terminal and cytoplasmic loop domains. Bouvier D, etal., J Biol Chem. 2009 Dec 4;284(49):34257-71. doi: 10.1074/jbc.M109.039594. Epub 2009 Oct 5.
6. Connexins: gaps in our knowledge of vascular function. Figueroa XF, etal., Physiology (Bethesda). 2004 Oct;19:277-84.
7. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
8. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
9. Somatic mutations in the connexin 40 gene (GJA5) in atrial fibrillation. Gollob MH, etal., N Engl J Med. 2006 Jun 22;354(25):2677-88.
10. Endothelial coordination of cerebral vasomotion via myoendothelial gap junctions containing connexins 37 and 40. Haddock RE, etal., Am J Physiol Heart Circ Physiol. 2006 Nov;291(5):H2047-56. Epub 2006 Jun 30.
11. Four novel members of the connexin family of gap junction proteins. Molecular cloning, expression, and chromosome mapping. Haefliger JA, etal., J Biol Chem 1992 Jan 25;267(3):2057-64.
12. Connexins 40 and 43 are differentially regulated within the kidneys of rats with renovascular hypertension. Haefliger JA, etal., Kidney Int. 2001 Jul;60(1):190-201.
13. Cardiac myocytes express multiple gap junction proteins. Kanter HL, etal., Circ Res 1992 Feb;70(2):438-44.
14. Improved radiation hybrid map of rat chromosome 2: colocalization of the genes encoding corticotropin-releasing hormone and IL6-receptor with quantitative trait loci regulating the inflammatory response. Laes JF, etal., Cytogenet Cell Genet 2001;92(1-2):130-3.
15. Changes of gap junctional cell-cell communication in overactive detrusor in rats. Li L, etal., Am J Physiol Cell Physiol. 2007 Nov;293(5):C1627-35. Epub 2007 Sep 13.
16. Shengmai San-derived herbal prevents the development of a vulnerable substrate for atrial fibrillation in a rat model of ischemic heart failure. Ma J, etal., Biomed Pharmacother. 2018 Apr;100:156-167. doi: 10.1016/j.biopha.2018.02.013. Epub 2018 Feb 8.
17. Effects of connexin-mimetic peptides on gap junction functionality and connexin expression in cultured vascular cells. Martin PE, etal., Br J Pharmacol. 2005 Mar;144(5):617-27.
18. Rapid endothelial cell-selective loading of connexin 40 antibody blocks endothelium-derived hyperpolarizing factor dilation in rat small mesenteric arteries. Mather S, etal., Circ Res. 2005 Aug 19;97(4):399-407. Epub 2005 Jul 21.
19. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
20. Regulatory effects of myoendothelial gap junction on vascular reactivity after hemorrhagic shock in rats. Ming J, etal., Shock. 2009 Jan;31(1):80-6. doi: 10.1097/SHK.0b013e31817d3eF2-11.
21. Glomerular expression of connexin 40 and connexin 43 in rat experimental glomerulonephritis. Morioka T, etal., Clin Exp Nephrol. 2012 Sep 4.
22. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
23. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
24. Online Mendelian Inheritance in Man, OMIM (TM). Online Mendelian Inheritance in Man, OMIM (TM).
25. Effects of chronic atrial fibrillation on gap junction distribution in human and rat atria. Polontchouk L, etal., J Am Coll Cardiol. 2001 Sep;38(3):883-91.
26. Expression and regulation of connexins in cultured ventricular myocytes isolated from adult rat hearts. Polontchouk LO, etal., Pflugers Arch 2002 Mar;443(5-6):676-89.
27. GOA pipeline RGD automated data pipeline
28. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
29. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
30. Sepsis up-regulates the expression of connexin 40 in rat aortic endothelium. Rignault S, etal., Crit Care Med. 2005 Jun;33(6):1302-10.
31. Decreased endothelial size and connexin expression in rat caudal arteries during hypertension. Rummery NM, etal., J Hypertens. 2002 Feb;20(2):247-53.
32. Mouse connexin40: gene structure and promoter analysis. Seul KH, etal., Genomics 1997 Nov 15;46(1):120-6.
33. Expression of connexins in the normal and obstructed developing kidney. Silverstein DM, etal., Pediatr Nephrol. 2003 Mar;18(3):216-24. Epub 2003 Feb 7.
34. Phenotype-specific effect of chromosome 1q21.1 rearrangements and GJA5 duplications in 2436 congenital heart disease patients and 6760 controls. Soemedi R, etal., Hum Mol Genet. 2012 Apr 1;21(7):1513-20. doi: 10.1093/hmg/ddr589. Epub 2011 Dec 22.
35. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
36. Connexins 37 and 40 transduce purinergic signals mediating renal autoregulation. Takenaka T, etal., Am J Physiol Regul Integr Comp Physiol. 2008 Jan;294(1):R1-11. Epub 2007 Oct 10.
37. Expression and role of connexins in the rat renal vasculature. Takenaka T, etal., Kidney Int. 2008 Feb;73(4):415-22. Epub 2007 Nov 28.
38. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
39. Gap junction channels formed by coexpressed connexin40 and connexin43. Valiunas V, etal., Am J Physiol Heart Circ Physiol. 2001 Oct;281(4):H1675-89.
40. Developmental changes of connexin40 and connexin43 mRNA distribution patterns in the rat heart. Van Kempen MJ, etal., Cardiovasc Res. 1996 Nov;32(5):886-900.
41. Study of the mechanism of antihypertensive peptides VPP and IPP in spontaneously hypertensive rats by DNA microarray analysis. Yamaguchi N, etal., Eur J Pharmacol. 2009 Oct 12;620(1-3):71-7. doi: 10.1016/j.ejphar.2009.08.005. Epub 2009 Aug 14.
42. Individual gap junction plaques contain multiple connexins in arterial endothelium. Yeh HI, etal., Circ Res. 1998 Dec 14-28;83(12):1248-63.
43. Age-related alteration of gap junction distribution and connexin expression in rat aortic endothelium. Yeh HI, etal., J Histochem Cytochem. 2000 Oct;48(10):1377-89.
44. Reduced EDHF responses and connexin activity in mesenteric arteries from the insulin-resistant obese Zucker rat. Young EJ, etal., Diabetologia. 2008 May;51(5):872-81. doi: 10.1007/s00125-008-0934-y. Epub 2008 Mar 7.
45. NaHS ameliorates diabetic vascular injury by correcting depressed connexin 43 and 40 in the vasculature in streptozotocin-injected rats. Zheng YF, etal., J Pharm Pharmacol. 2010 May;62(5):615-21. doi: 10.1211/jpp/62.05.0009.
Additional References at PubMed
PMID:7930207   PMID:9501069   PMID:9501070   PMID:9709407   PMID:10515563   PMID:10747000   PMID:10969038   PMID:11046183   PMID:11866539   PMID:12435353   PMID:14693688   PMID:14732399  
PMID:15016632   PMID:15489334   PMID:15923624   PMID:16284078   PMID:16352648   PMID:17255527   PMID:17546509   PMID:17584645   PMID:17632690   PMID:18239136   PMID:18599871   PMID:19129462  
PMID:19465552   PMID:19588758   PMID:20530546   PMID:20606116   PMID:20805582   PMID:21543330   PMID:22203979   PMID:22247482   PMID:22336507   PMID:22403875   PMID:23348765   PMID:26927369  
PMID:27304225   PMID:28157110   PMID:28457700   PMID:28870649  


Genomics

Comparative Map Data
Gja5
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82187,291,227 - 187,310,770 (+)NCBIGRCr8
mRatBN7.22184,602,407 - 184,621,952 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2184,564,475 - 184,621,952 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2192,244,465 - 192,263,988 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02190,042,684 - 190,062,193 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02184,877,034 - 184,896,564 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02199,162,745 - 199,184,942 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2199,162,745 - 199,184,939 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02218,648,368 - 218,669,354 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42191,824,118 - 191,843,867 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12191,786,871 - 191,806,619 (+)NCBI
Celera2177,098,223 - 177,117,685 (+)NCBICelera
Cytogenetic Map2q34NCBI
GJA5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381147,756,199 - 147,773,351 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1147,756,199 - 147,773,362 (-)EnsemblGRCh38hg38GRCh38
GRCh371147,228,332 - 147,245,455 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361145,694,956 - 145,712,108 (-)NCBINCBI36Build 36hg18NCBI36
Build 341144,453,708 - 144,457,501NCBI
Celera1121,738,476 - 121,755,641 (+)NCBICelera
Cytogenetic Map1q21.2NCBI
HuRef1120,641,850 - 120,658,997 (-)NCBIHuRef
CHM1_11149,124,325 - 149,141,488 (-)NCBICHM1_1
T2T-CHM13v2.01147,034,309 - 147,051,468 (+)NCBIT2T-CHM13v2.0
Gja5
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39396,939,718 - 96,960,950 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl396,812,009 - 96,984,732 (+)EnsemblGRCm39 Ensembl
GRCm38397,032,402 - 97,053,634 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl396,904,693 - 97,077,416 (+)EnsemblGRCm38mm10GRCm38
MGSCv37396,836,339 - 96,857,557 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36397,117,821 - 97,139,039 (+)NCBIMGSCv36mm8
Celera398,439,607 - 98,460,828 (+)NCBICelera
Cytogenetic Map3F2.1NCBI
cM Map342.04NCBI
Gja5
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955568635,042 - 653,349 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955568635,319 - 652,692 (+)NCBIChiLan1.0ChiLan1.0
GJA5
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21101,927,011 - 101,952,954 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11101,515,393 - 101,539,948 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01123,200,111 - 123,224,626 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11112,306,880 - 112,331,358 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1112,328,337 - 112,329,413 (+)Ensemblpanpan1.1panPan2
GJA5
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11758,289,327 - 58,305,315 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1758,289,327 - 58,305,315 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1757,757,715 - 57,773,685 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01759,286,062 - 59,301,971 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1759,285,495 - 59,302,023 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11758,159,018 - 58,175,010 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01758,219,654 - 58,235,621 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01758,946,248 - 58,962,243 (-)NCBIUU_Cfam_GSD_1.0
Gja5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505820,393,289 - 20,403,471 (-)NCBIHiC_Itri_2
SpeTri2.0NW_004936867269,477 - 279,549 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GJA5
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl499,854,392 - 99,871,286 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1499,854,129 - 99,871,288 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.24109,687,517 - 109,704,699 (+)NCBISscrofa10.2Sscrofa10.2susScr3
GJA5
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Vero_WHO_p1.0NW_02366603814,460,790 - 14,478,590 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Gja5
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462477216,813,011 - 16,814,084 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462477216,810,723 - 16,828,328 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Gja5
76 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:225
Count of miRNA genes:161
Interacting mature miRNAs:194
Transcripts:ENSRNOT00000023488
Prediction methods:Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1358913Cm41Cardiac mass QTL 412.73heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
1358917Cm42Cardiac mass QTL 422.82heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
1298074Bp164Blood pressure QTL 1640.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)242804607202447032Rat
1298085Bp165Blood pressure QTL 1650.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)242804607202447032Rat
61467Bp14Blood pressure QTL 142.2arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)243154682202446871Rat
61467Bp14Blood pressure QTL 142.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)243154682202446871Rat
631266Bp132Blood pressure QTL 1320.0005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)246123260202447032Rat
1331760Bp206Blood pressure QTL 2063.62454arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)256043031202447032Rat
1298080Bp163Blood pressure QTL 1630.02arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)266118275202447032Rat
1354648Bp239Blood pressure QTL 2390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)266118463226797303Rat
1354605Rf48Renal function QTL 482.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)274786664206665859Rat
61374Edpm2Estrogen-dependent pituitary mass QTL 24.420.86pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)276539322202447032Rat
1581569Uae32Urinary albumin excretion QTL 320.0001urine protein amount (VT:0005160)urine albumin excretion rate (CMO:0000757)278665619219826953Rat
724534Uae6Urinary albumin excretion QTL 610urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)278665619249053267Rat
8662832Vetf7Vascular elastic tissue fragility QTL 73.5aorta elastin amount (VT:0003905)aorta wall extracellular elastin dry weight to aorta wall dry weight ratio (CMO:0002002)281689826221035911Rat
1354622Kidm16Kidney mass QTL 163kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)281754530222436696Rat
1354649Kidm17Kidney mass QTL 172.9kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)281754530227146641Rat
631507Bp105Blood pressure QTL 1050.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2112456140212696837Rat
634308Sach6Saccharin preference QTL 64.9taste sensitivity trait (VT:0001986)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)2112456140212696837Rat
1359030Bp277Blood pressure QTL 277arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2114837527185876470Rat
1359030Bp277Blood pressure QTL 277arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2114837527185876470Rat
1578648Bss11Bone structure and strength QTL 114.7femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)2114837527211674221Rat
1554319Bmd2Bone mineral density QTL 213.40.0001lumbar vertebra area (VT:0010570)lumbar vertebra cross-sectional area (CMO:0001689)2114837675212549332Rat
1300165Rf9Renal function QTL 93.28kidney glomerulus integrity trait (VT:0010546)index of glomerular damage (CMO:0001135)2133914684202447032Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2135552573202446871Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2135552573202446871Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2135552573202446871Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)2135552573202446871Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)absolute change in systolic blood pressure (CMO:0000607)2135552573202446871Rat
1298076Bp166Blood pressure QTL 1660.0009arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2136445150202447032Rat
1581502Esta3Estrogen-induced thymic atrophy QTL 3thymus mass (VT:0004954)thymus wet weight (CMO:0000855)2136916935189599348Rat
1359022Ppulsi1Prepulse inhibition QTL 13.63prepulse inhibition trait (VT:0003088)acoustic startle response measurement (CMO:0001519)2136916935213594495Rat
1331794Bp202Blood pressure QTL 2023.66819arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2141194931223265385Rat
1331805Cm29Cardiac mass QTL 293.50746heart mass (VT:0007028)heart wet weight (CMO:0000069)2141194931223265385Rat
71113Cari2Carrageenan-induced inflammation QTL 22.70.009hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)2141596551202447032Rat
724568Uae13Urinary albumin excretion QTL 134.4urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)2143157029210020885Rat
10043136Iddm54Insulin dependent diabetes mellitus QTL 543.40.0001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)2143657411190602963Rat
10043136Iddm54Insulin dependent diabetes mellitus QTL 543.40.0001blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)2143657411190602963Rat
61401Niddm2Non-insulin dependent diabetes mellitus QTL 24.54blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)2144599348189599348Rat
1598833Bp295Blood pressure QTL 2953.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2147798556192798556Rat
1641925Alcrsp2Alcohol response QTL 2response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2149559561221167075Rat
1641891Alcrsp17Alcohol response QTL 17response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2149559561249053267Rat
1598805Memor8Memory QTL 83exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)2150341585189039377Rat
631501Bp101Blood pressure QTL 1012.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2150341684202446871Rat
2301966Bp322Blood pressure QTL 3223.58arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2150540301202447032Rat
1354609Niddm62Non-insulin dependent diabetes mellitus QTL 624.720.000006insulin secretion trait (VT:0003564)plasma insulin level (CMO:0000342)2150540301202447032Rat
12879836Kidm61Kidney mass QTL 610.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)2152413072185122374Rat
12879837Am2Aortic mass QTL 20.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)2152413072185122374Rat
12879838Cm86Cardiac mass QTL 860.002heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)2152413072185122374Rat
12879839Cm85Cardiac mass QTL 850.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)2152413072185122374Rat
12879840Bw179Body weight QTL 1790.005body mass (VT:0001259)body weight (CMO:0000012)2152413072185122374Rat
1359032Hrtrt18Heart rate QTL 18heart pumping trait (VT:2000009)heart rate (CMO:0000002)2157142078192625452Rat
1358900Bw48Body weight QTL 484.88body mass (VT:0001259)body weight (CMO:0000012)2157142078211086598Rat
8662843Vetf9Vascular elastic tissue fragility QTL 92.05thoracic aorta molecular composition trait (VT:0010568)aorta wall extracellular elastin dry weight to aorta wall extracellular collagen weight ratio (CMO:0002003)2157142078226277316Rat
1302793Bw16Body weight QTL 1650.0001body mass (VT:0001259)body weight (CMO:0000012)2157142209202446871Rat
7488925Bp364Blood pressure QTL 3640.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2160564068205564068Rat
1358356Srcrt1Stress Responsive Cort QTL13.66blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)2161699179222436696Rat
7488927Bp365Blood pressure QTL 3650.008arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2162765032207765032Rat
2306901Bp337Blood pressure QTL 3370.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2164073756227146641Rat
1598838Bp290Blood pressure QTL 2901.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2166539266211539266Rat
1549833Bp257Blood pressure QTL 2570.003arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2168354880185122374Rat
1331734Bp204Blood pressure QTL 2043.61192arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2168358098223265385Rat
2307174Activ3Activity QTL 34.830.000058locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)2168594495213594495Rat
61469Bp16Blood pressure QTL 165.64arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)2169745596214745596Rat
70162Bp63Blood pressure QTL 635.64arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)2169745596214745596Rat
2293084Iddm26Insulin dependent diabetes mellitus QTL 262.9blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)2174930955213594495Rat
2300189Bmd48Bone mineral density QTL 485.80.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)2179335906224335906Rat
61417Cia10Collagen induced arthritis QTL 103.4joint integrity trait (VT:0010548)experimental arthritis severity measurement (CMO:0001459)2179946951224946951Rat
8694435Bw166Body weight QTL 16614.080.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)2182171407227171407Rat
9589044Scfw1Subcutaneous fat weight QTL 15.80.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)2182171407227171407Rat
8694383Bw158Body weight QTL 1587.690.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)2182171407227171407Rat
8694194Abfw1Abdominal fat weight QTL 111.70.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)2182171407227171407Rat
4889834Pur24Proteinuria QTL 245.80.014urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)2184114274202447032Rat
738013Alc15Alcohol consumption QTL 154.10.00022consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)2184165752229165752Rat

Markers in Region
Gja5  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22184,619,868 - 184,620,068 (+)MAPPERmRatBN7.2
Rnor_6.02199,182,858 - 199,183,057NCBIRnor6.0
Rnor_5.02218,667,271 - 218,667,470UniSTSRnor5.0
RGSC_v3.42191,841,784 - 191,841,983UniSTSRGSC3.4
Celera2177,115,694 - 177,115,893UniSTS
Cytogenetic Map2q34UniSTS
D2Wox62  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22184,621,312 - 184,621,524 (+)MAPPERmRatBN7.2
Rnor_6.02199,184,302 - 199,184,513NCBIRnor6.0
Rnor_5.02218,668,715 - 218,668,926UniSTSRnor5.0
RGSC_v3.42191,843,228 - 191,843,439UniSTSRGSC3.4
Celera2177,117,138 - 177,117,257UniSTS
Cytogenetic Map2q34UniSTS
RH134117  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22184,621,613 - 184,621,795 (+)MAPPERmRatBN7.2
Rnor_6.02199,184,603 - 199,184,784NCBIRnor6.0
Rnor_5.02218,669,016 - 218,669,197UniSTSRnor5.0
RGSC_v3.42191,843,529 - 191,843,710UniSTSRGSC3.4
Celera2177,117,347 - 177,117,528UniSTS
RH 3.4 Map21247.3UniSTS
Cytogenetic Map2q34UniSTS
UniSTS:275686  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22184,618,959 - 184,619,214 (+)MAPPERmRatBN7.2
Rnor_6.02199,181,949 - 199,182,203NCBIRnor6.0
Rnor_5.02218,666,362 - 218,666,616UniSTSRnor5.0
RGSC_v3.42191,840,875 - 191,841,129UniSTSRGSC3.4
Celera2177,114,785 - 177,115,039UniSTS
Cytogenetic Map2q34UniSTS


Genetic Models
This gene Gja5 is modified in the following models/strains:
WKY-Gja5em1Mcwi    


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 26 14 11 11
Low 3 17 51 37 17 37 8 11 64 21 29 8
Below cutoff 6 4 2 4 10 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000023488   ⟹   ENSRNOP00000023488
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2184,607,596 - 184,621,952 (+)Ensembl
Rnor_6.0 Ensembl2199,162,745 - 199,184,939 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000108116   ⟹   ENSRNOP00000076921
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2184,602,293 - 184,621,952 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000115241   ⟹   ENSRNOP00000080221
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2184,564,475 - 184,621,952 (+)Ensembl
RefSeq Acc Id: NM_019280   ⟹   NP_062153
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82187,291,227 - 187,310,770 (+)NCBI
mRatBN7.22184,602,408 - 184,621,952 (+)NCBI
Rnor_6.02199,162,745 - 199,184,942 (+)NCBI
Rnor_5.02218,648,368 - 218,669,354 (+)NCBI
RGSC_v3.42191,824,118 - 191,843,867 (+)RGD
Celera2177,098,223 - 177,117,685 (+)RGD
Sequence:
RefSeq Acc Id: XM_063282415   ⟹   XP_063138485
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82187,295,920 - 187,310,770 (+)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_062153   ⟸   NM_019280
- UniProtKB: P28234 (UniProtKB/Swiss-Prot),   A6K3A5 (UniProtKB/TrEMBL),   A0A654ICD7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000023488   ⟸   ENSRNOT00000023488
RefSeq Acc Id: ENSRNOP00000080221   ⟸   ENSRNOT00000115241
RefSeq Acc Id: ENSRNOP00000076921   ⟸   ENSRNOT00000108116
RefSeq Acc Id: XP_063138485   ⟸   XM_063282415
- Peptide Label: isoform X1
- UniProtKB: P28234 (UniProtKB/Swiss-Prot),   A6K3A5 (UniProtKB/TrEMBL)
Protein Domains
Connexin N-terminal   Gap junction protein cysteine-rich

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P28234-F1-model_v2 AlphaFold P28234 1-356 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13691593
Promoter ID:EPDNEW_R2117
Type:multiple initiation site
Name:Gja5_1
Description:gap junction protein, alpha 5
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.02199,162,718 - 199,162,778EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2692 AgrOrtholog
BioCyc Gene G2FUF-51953 BioCyc
Ensembl Genes ENSRNOG00000017484 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOG00055032410 UniProtKB/Swiss-Prot
  ENSRNOG00060012968 UniProtKB/Swiss-Prot
  ENSRNOG00065032655 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000023488.7 UniProtKB/Swiss-Prot
  ENSRNOT00000108116 ENTREZGENE
  ENSRNOT00000108116.1 UniProtKB/Swiss-Prot
  ENSRNOT00000115241.1 UniProtKB/Swiss-Prot
  ENSRNOT00055055966 UniProtKB/Swiss-Prot
  ENSRNOT00055055970 UniProtKB/Swiss-Prot
  ENSRNOT00055055972 UniProtKB/Swiss-Prot
  ENSRNOT00060022073 UniProtKB/Swiss-Prot
  ENSRNOT00060022077 UniProtKB/Swiss-Prot
  ENSRNOT00060022083 UniProtKB/Swiss-Prot
  ENSRNOT00065056160 UniProtKB/Swiss-Prot
  ENSRNOT00065056165 UniProtKB/Swiss-Prot
  ENSRNOT00065056168 UniProtKB/Swiss-Prot
Gene3D-CATH 1.20.1440.80 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7097997 IMAGE-MGC_LOAD
InterPro Connexin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Connexin40 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Connexin_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Connexin_CCC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Connexin_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Connexin_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Connexin_N_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cx40_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:50563 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:91719 IMAGE-MGC_LOAD
NCBI Gene 50563 ENTREZGENE
PANTHER CONNEXIN UniProtKB/TrEMBL
  GAP JUNCTION ALPHA-5 PROTEIN UniProtKB/TrEMBL
  PTHR11984 UniProtKB/Swiss-Prot
  PTHR11984:SF13 UniProtKB/Swiss-Prot
Pfam Connexin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Connexin40_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB GJA5 RGD
PhenoGen Gja5 PhenoGen
PRINTS CONNEXIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CONNEXINA5 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE CONNEXINS_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CONNEXINS_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000017484 RatGTEx
  ENSRNOG00055032410 RatGTEx
  ENSRNOG00060012968 RatGTEx
  ENSRNOG00065032655 RatGTEx
SMART CNX UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Connexin_CCC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP Connexin43 UniProtKB/TrEMBL, UniProtKB/Swiss-Prot
TIGR TC218949
UniProt A0A654ICD7 ENTREZGENE, UniProtKB/TrEMBL
  A6K3A5 ENTREZGENE, UniProtKB/TrEMBL
  CXA5_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-10-23 Gja5  gap junction protein, alpha 5  Gja5  gap junction membrane channel protein alpha 5  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Gja5  gap junction membrane channel protein alpha 5      Name updated 70584 APPROVED