Gfra1 (GDNF family receptor alpha 1) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Behavioral & Substance Use Disorder Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Gfra1 (GDNF family receptor alpha 1) Rattus norvegicus
Analyze
Symbol: Gfra1
Name: GDNF family receptor alpha 1
RGD ID: 2681
Description: Enables glial cell-derived neurotrophic factor receptor activity; integrin binding activity; and neurotrophin receptor activity. Involved in several processes, including glial cell-derived neurotrophic factor receptor signaling pathway; male gonad development; and positive regulation of peptidyl-tyrosine phosphorylation. Located in several cellular components, including axon; external side of plasma membrane; and neuronal cell body. Part of plasma membrane protein complex and receptor complex. Used to study Parkinsonism. Biomarker of Parkinsonism; brain ischemia; and sciatic neuropathy. Human ortholog(s) of this gene implicated in renal agenesis. Orthologous to human GFRA1 (GDNF family receptor alpha 1); INTERACTS WITH 1-naphthyl isothiocyanate; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: GDNF family receptor alpha-1; GDNF family receptor alpha-1-like; GDNF receptor alpha; GDNF receptor alpha-1; GDNFR-alpha; GDNFR-alpha-1; GFR-alpha-1; glial cell line derived neurotrophic factor family receptor alpha 1; Glial cell line-derived neurotrophic factor receptor alpha; LOC100911751; RET ligand 1; TGF-beta-related neurotrophic factor receptor 1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81267,325,297 - 267,557,037 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1267,326,817 - 267,556,501 (-)EnsemblGRCr8
mRatBN7.21257,315,682 - 257,552,004 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1257,321,742 - 257,551,473 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1265,542,982 - 265,775,408 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01272,248,912 - 272,481,436 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01264,892,893 - 265,124,304 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01279,203,046 - 279,572,789 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01286,571,283 - 286,640,993 (-)NCBIRnor_5.0Rnor_5.0rn5
Rnor_5.01286,932,096 - 286,934,801 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41264,614,329 - 264,875,486 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1253,001,051 - 253,229,417 (-)NCBICelera
RGSC_v3.11264,825,373 - 265,086,531 (-)NCBI
Cytogenetic Map1q55NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
(2,4,5-trichlorophenoxy)acetic acid  (ISO)
1,1,1-trichloroethane  (ISO)
1,1-dichloroethene  (ISO)
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (EXP)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,4-methylenedioxymethamphetamine  (ISO)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP)
acrylamide  (EXP)
actinomycin D  (ISO)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
aldrin  (ISO)
all-trans-retinoic acid  (EXP,ISO)
allethrin  (EXP)
amitrole  (EXP)
ammonium chloride  (EXP)
amoxicillin  (ISO)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
atrazine  (EXP)
belinostat  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
butanal  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
capsaicin  (EXP)
carbamazepine  (ISO)
carbon nanotube  (ISO)
chlorohydrocarbon  (EXP)
cisplatin  (ISO)
coumestrol  (ISO)
cyclophosphamide  (ISO)
cyclosporin A  (EXP,ISO)
cyhalothrin  (EXP)
cypermethrin  (EXP)
DDD  (ISO)
DDE  (ISO)
DDT  (ISO)
dexamethasone  (EXP,ISO)
Didecyldimethylammonium  (ISO)
dieldrin  (ISO)
dioxygen  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endrin  (ISO)
Enterolactone  (ISO)
entinostat  (ISO)
epoxiconazole  (ISO)
ethanol  (EXP,ISO)
fenvalerate  (EXP)
fulvestrant  (ISO)
furan  (EXP)
gamma-hexachlorocyclohexane  (ISO)
genistein  (ISO)
GSK-J4  (ISO)
GW 4064  (ISO)
inulin  (ISO)
L-ascorbic acid  (ISO)
lead(0)  (ISO)
methapyrilene  (EXP)
methimazole  (EXP)
methoxychlor  (EXP)
methylmercury chloride  (EXP,ISO)
Moniliformin  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
Muraglitazar  (EXP)
naproxen  (EXP)
nickel atom  (ISO)
Nutlin-3  (ISO)
O-methyleugenol  (ISO)
okadaic acid  (ISO)
p-chloromercuribenzoic acid  (ISO)
paclitaxel  (ISO)
paracetamol  (ISO)
paraquat  (EXP)
pentanal  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenacetin  (EXP)
phenobarbital  (ISO)
phenylhydrazine  (EXP)
phenylmercury acetate  (ISO)
pioglitazone  (ISO)
pirinixic acid  (EXP,ISO)
potassium chromate  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
propanal  (ISO)
pyrethrins  (EXP)
resmethrin  (ISO)
resveratrol  (ISO)
rotenone  (EXP)
SB 431542  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
simvastatin  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium fluoride  (ISO)
stigmasterol  (ISO)
sulfadimethoxine  (EXP)
sumatriptan  (EXP)
tert-butyl hydroperoxide  (ISO)
testosterone  (EXP)
tetrachloromethane  (EXP)
thioacetamide  (EXP)
titanium dioxide  (ISO)
triadimefon  (ISO)
trichostatin A  (ISO)
triclosan  (ISO)
troglitazone  (EXP)
uranium atom  (EXP)
valproic acid  (ISO)
vorinostat  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Up-regulation of GDNFR-alpha and c-ret mRNA in facial motor neurons following facial nerve injury in the rat. Burazin TC and Gundlach AL, Brain Res Mol Brain Res. 1998 Apr;55(2):331-6.
2. Integrin beta1 is involved in the signaling of glial cell line-derived neurotrophic factor. Cao JP, etal., J Comp Neurol. 2008 Jul 10;509(2):203-10.
3. Glial cell line-derived neurotrophic factor promotes olfactory ensheathing cells migration. Cao L, etal., Glia. 2006 Nov 1;54(6):536-44.
4. Glial cell line-derived neurotrophic factor (GDNF) receptor alpha-1 (GFR alpha 1) is highly selective for GDNF versus artemin. Carmillo P, etal., Biochemistry. 2005 Feb 22;44(7):2545-54.
5. Expression of GFRalpha1 receptor splicing variants with different biochemical properties is modulated during kidney development. Charlet-Berguerand N, etal., Cell Signal. 2004 Dec;16(12):1425-34.
6. Down-regulation of GFRalpha-1 expression by antisense oligodeoxynucleotide attenuates electroacupuncture analgesia on heat hyperalgesia in a rat model of neuropathic pain. Dong ZQ, etal., Brain Res Bull. 2006 Mar 15;69(1):30-6. Epub 2005 Nov 28.
7. Distinct structural elements in GDNF mediate binding to GFRalpha1 and activation of the GFRalpha1-c-Ret receptor complex. Eketjäll S, etal., EMBO J. 1999 Nov 1;18(21):5901-10.
8. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
9. SorLA controls neurotrophic activity by sorting of GDNF and its receptors GFRα1 and RET. Glerup S, etal., Cell Rep. 2013 Jan 31;3(1):186-99. doi: 10.1016/j.celrep.2012.12.011. Epub 2013 Jan 17.
10. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
11. RET recognition of GDNF-GFRα1 ligand by a composite binding site promotes membrane-proximal self-association. Goodman KM, etal., Cell Rep. 2014 Sep 25;8(6):1894-1904. doi: 10.1016/j.celrep.2014.08.040. Epub 2014 Sep 18.
12. Characterization of glial cell line-derived neurotrophic factor family receptor alpha-1 in peripheral nerve Schwann cells. Hase A, etal., J Neurochem. 2005 Oct;95(2):537-43. Epub 2005 Aug 8.
13. GDNF-induced activation of the ret protein tyrosine kinase is mediated by GDNFR-alpha, a novel receptor for GDNF. Jing S, etal., Cell 1996 Jun 28;85(7):1113-24.
14. Developmental expression of glial cell-line derived neurotrophic factor, neurturin, and their receptor mRNA in the rat urinary bladder. Kawakami T, etal., Neurourol Urodyn 2003;22(1):83-8.
15. Sciatic nerve injury in adult rats causes distinct changes in the central projections of sensory neurons expressing different glial cell line-derived neurotrophic factor family receptors. Keast JR, etal., J Comp Neurol. 2010 Aug 1;518(15):3024-45.
16. Induction of glial cell line-derived neurotrophic factor receptor proteins in cerebral cortex and striatum after permanent middle cerebral artery occlusion in rats. Kitagawa H, etal., Brain Res. 1999 Jul 10;834(1-2):190-5.
17. Regulation of GDNF and its receptor components GFR-alpha1, -alpha2 and Ret during development and in the mature retino-collicular pathway. Kretz A, etal., Brain Res. 2006 May 23;1090(1):1-14. Epub 2006 May 2.
18. Signaling of glial cell line-derived neurotrophic factor and its receptor GFRalpha1 induce Nurr1 and Pitx3 to promote survival of grafted midbrain-derived neural stem cells in a rat model of Parkinson disease. Lei Z, etal., J Neuropathol Exp Neurol. 2011 Sep;70(9):736-47.
19. GDNF, Ret, GFRalpha1 and 2 in the adult rat retino-tectal system after optic nerve transection. Lindqvist N, etal., Exp Neurol. 2004 Jun;187(2):487-99.
20. Gene Expression Profiling of Rat Testis Development During the Early Post-Natal Stages. Liu T, etal., Reprod Domest Anim. 2011 Nov 24. doi: 10.1111/j.1439-0531.2011.01950.x.
21. Regulation of c-Ret, GFRalpha1, and GFRalpha2 in the substantia nigra pars compacta in a rat model of Parkinson's disease. Marco S, etal., J Neurobiol. 2002 Sep 15;52(4):343-51.
22. Immunohistochemical expression of two members of the GDNF family of growth factors and their receptors in the olfactory system. Maroldt H, etal., J Neurocytol. 2005 Sep;34(3-5):241-55. Epub 2006 Jul 13.
23. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
24. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
25. GFR alpha-1 receptor expression in the aging nigrostriatal and mesoaccumbens pathways. Pruett BS and Salvatore MF, J Neurochem. 2010 Nov;115(3):707-15. doi: 10.1111/j.1471-4159.2010.06963.x. Epub 2010 Sep 28.
26. GOA pipeline RGD automated data pipeline
27. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
28. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
29. Glial cell line-derived neurotrophic factor-dependent RET activation can be mediated by two different cell-surface accessory proteins. Sanicola M, etal., Proc Natl Acad Sci U S A 1997 Jun 10;94(12):6238-43.
30. Time course study of GFRalpha-1 expression in an animal model of stroke. Sarabi A, etal., Exp Neurol. 2001 Aug;170(2):283-9.
31. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
32. Discordant expression of c-Ret and glial cell line-derived neurotrophic factor receptor alpha-1 mRNAs in response to motor nerve injury in neonate rats. Tsujino H, etal., Brain Res Mol Brain Res. 1999 Jul 5;70(2):298-303.
33. Conditional ablation of GFRalpha1 in postmigratory enteric neurons triggers unconventional neuronal death in the colon and causes a Hirschsprung's disease phenotype. Uesaka T, etal., Development. 2007 Jun;134(11):2171-81.
34. Expression of glial cell line-derived neurotrophic factor and GDNFR-alpha mRNAs in human peripheral neuropathies. Yamamoto M, etal., Brain Res. 1998 Nov 2;809(2):175-81.
35. [The expression of glial cell derived neurotrophic factor and its receptor GDNFR-alpha and GDNFR-beta mRNA in spinal cord, brainstem and frontal cortex during morphine withdrawal in rats] Zhou W, etal., Zhonghua Yi Xue Za Zhi 2000 Feb;80(2):135-9.
Additional References at PubMed
PMID:8657309   PMID:9192898   PMID:10719212   PMID:11069590   PMID:12535958   PMID:14563851   PMID:15044950   PMID:15225646   PMID:15306125   PMID:16289634   PMID:16513266   PMID:17240430  
PMID:17298301   PMID:17538205   PMID:17640046   PMID:18085594   PMID:18845535   PMID:19056867   PMID:19845157   PMID:20350599   PMID:20807316   PMID:21133924   PMID:22266674   PMID:23321789  
PMID:23767459   PMID:25043933   PMID:26599339   PMID:30541958   PMID:37178997  


Genomics

Comparative Map Data
Gfra1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81267,325,297 - 267,557,037 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1267,326,817 - 267,556,501 (-)EnsemblGRCr8
mRatBN7.21257,315,682 - 257,552,004 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1257,321,742 - 257,551,473 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1265,542,982 - 265,775,408 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01272,248,912 - 272,481,436 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01264,892,893 - 265,124,304 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01279,203,046 - 279,572,789 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01286,571,283 - 286,640,993 (-)NCBIRnor_5.0Rnor_5.0rn5
Rnor_5.01286,932,096 - 286,934,801 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41264,614,329 - 264,875,486 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1253,001,051 - 253,229,417 (-)NCBICelera
RGSC_v3.11264,825,373 - 265,086,531 (-)NCBI
Cytogenetic Map1q55NCBI
GFRA1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3810116,056,925 - 116,274,705 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl10116,056,925 - 116,276,803 (-)Ensemblhg38GRCh38
GRCh3710117,816,436 - 118,034,217 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3610117,812,943 - 118,022,966 (-)NCBIBuild 36Build 36hg18NCBI36
Build 3410117,813,264 - 118,022,966NCBI
Celera10111,545,807 - 111,762,346 (-)NCBICelera
Cytogenetic Map10q25.3NCBI
HuRef10111,444,080 - 111,660,347 (-)NCBIHuRef
CHM1_110118,099,661 - 118,316,231 (-)NCBICHM1_1
T2T-CHM13v2.010116,951,015 - 117,168,680 (-)NCBIT2T-CHM13v2.0
Gfra1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391958,224,013 - 58,444,387 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1958,224,036 - 58,444,341 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381958,235,581 - 58,455,946 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1958,235,604 - 58,455,909 (-)Ensemblmm10GRCm38
MGSCv371958,311,182 - 58,528,956 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361958,289,942 - 58,507,716 (-)NCBIMGSCv36mm8
Celera1960,429,999 - 60,650,471 (-)NCBICelera
Cytogenetic Map19D2NCBI
cM Map1954.18NCBI
Gfra1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543120,866,685 - 21,070,853 (-)Ensembl
ChiLan1.0NW_00495543120,859,152 - 21,070,886 (-)NCBIChiLan1.0ChiLan1.0
GFRA1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v28127,932,626 - 128,150,100 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan110127,937,964 - 128,154,536 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v010112,645,574 - 112,862,413 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.110116,079,056 - 116,295,195 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl10116,079,063 - 116,295,164 (-)EnsemblpanPan2panpan1.1
GFRA1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12826,707,592 - 26,910,029 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2826,709,645 - 26,909,992 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2826,859,169 - 27,062,134 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02827,243,451 - 27,446,937 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2827,243,342 - 27,446,257 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12826,799,655 - 27,002,551 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02826,812,101 - 27,015,351 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02827,006,585 - 27,209,685 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Gfra1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721319,299,126 - 19,490,965 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364866,071,023 - 6,262,165 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049364866,066,108 - 6,262,055 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GFRA1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl14126,277,875 - 126,499,465 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.114126,273,558 - 126,499,957 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.214137,525,348 - 137,748,038 (-)NCBISscrofa10.2Sscrofa10.2susScr3
GFRA1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.19108,869,444 - 109,088,803 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl9108,876,855 - 109,087,488 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604870,112,995 - 70,332,336 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Gfra1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473730,324,515 - 30,526,486 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462473730,325,962 - 30,526,311 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Gfra1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1257,669,137 - 57,895,565 (+)NCBIRrattus_CSIRO_v1

miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:331
Count of miRNA genes:200
Interacting mature miRNAs:249
Transcripts:ENSRNOT00000023667, ENSRNOT00000066428
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
634313Niddm43Non-insulin dependent diabetes mellitus QTL 43blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1208479811269633915Rat
1549910Bw54Body weight QTL 540.05body mass (VT:0001259)body weight (CMO:0000012)1263946994269633915Rat
70211Niddm24Non-insulin dependent diabetes mellitus QTL 243.79blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1224633915269633915Rat
724552Glom2Glomerulus QTL 23.30.0001kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli directly contacting the kidney surface (CMO:0001001)1232312773270518180Rat
61327Eae7Experimental allergic encephalomyelitis QTL 75.6body mass (VT:0001259)change in body weight (CMO:0002045)1226175591270518180Rat
1578775Iddm21Insulin dependent diabetes mellitus QTL 214.13blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1245782829270518180Rat
631837Niddm35Non-insulin dependent diabetes mellitus QTL 350.01blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1248619887269633915Rat
1600397Edcs4Endometrial carcinoma susceptibility QTL 42.2uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)1176288899270518180Rat
631836Stl31Serum triglyceride level QTL 314.645e-06blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)1247133834270518180Rat
1549837Hcar15Hepatocarcinoma resistance QTL 150.05liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1162548015270518180Rat
1598853Memor3Memory QTL 34.5exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)1152919152268496042Rat
1600390Niddm64Non-insulin dependent diabetes mellitus QTL 640.003blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1257624997270518180Rat
1300108Rf8Renal function QTL 83.75renal blood flow trait (VT:2000006)absolute change in renal vascular resistance (CMO:0001900)1237995023269633915Rat
734767Niddm57Non-insulin dependent diabetes mellitus QTL 57body mass (VT:0001259)body weight (CMO:0000012)1233480549270108840Rat
631215Stl8Serum triglyceride level QTL 89.270.0001blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)1234540191270518180Rat
7387289Uae45Urinary albumin excretion QTL 452.860.0021urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1233204160270518180Rat
631843Bw116Body weight QTL 1164.10.016abdominal adipose amount (VT:1000220)abdominal fat pad weight (CMO:0000088)1233480549270108840Rat
731175Uae20Urinary albumin excretion QTL 203.50.0018urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1207163993269633915Rat
1598839Rf56Renal function QTL 56renal blood flow trait (VT:2000006)ratio of change in renal blood flow to change in renal perfusion pressure (CMO:0001239)1255849111270518180Rat
1581544Rf52Renal function QTL 520.05urine total protein amount (VT:0000032)urine protein excretion rate to body weight ratio (CMO:0001099)1241569529269633915Rat
631536Lnnr2Liver neoplastic nodule remodeling QTL 22.90.0005liver integrity trait (VT:0010547)liver remodeling tumorous lesion number to liver total tumorous lesion number ratio (CMO:0001705)1243953669270518180Rat
734769Niddm58Non-insulin dependent diabetes mellitus QTL 58body mass (VT:0001259)body weight (CMO:0000012)1225108840270108840Rat
738032Hcas5Hepatocarcinoma susceptibility QTL 53.12liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1185857683270518180Rat
2302040Pia35Pristane induced arthritis QTL 353.80.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)1226175591270518180Rat
631669Iddm9Insulin dependent diabetes mellitus QTL 92.80.039blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1233349180270518180Rat
1598821Rf55Renal function QTL 556.3renal blood flow trait (VT:2000006)ratio of change in renal blood flow to change in renal perfusion pressure (CMO:0001239)1228174566270518180Rat

Markers in Region
RH132446  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21257,424,447 - 257,424,659 (+)MAPPERmRatBN7.2
Rnor_6.01279,415,771 - 279,415,982NCBIRnor6.0
Rnor_6.01279,311,075 - 279,311,286NCBIRnor6.0
Rnor_5.01286,777,918 - 286,778,129UniSTSRnor5.0
Rnor_5.01286,673,222 - 286,673,433UniSTSRnor5.0
RGSC_v3.41264,747,990 - 264,748,201UniSTSRGSC3.4
Celera1253,102,980 - 253,103,191UniSTS
RH 3.4 Map11689.5UniSTS
Cytogenetic Map1q55UniSTS
AW529053  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21257,320,279 - 257,320,473 (+)MAPPERmRatBN7.2
Rnor_6.01279,207,644 - 279,207,837NCBIRnor6.0
Rnor_5.01286,571,341 - 286,571,534UniSTSRnor5.0
RGSC_v3.41264,614,387 - 264,614,580UniSTSRGSC3.4
Celera1253,001,109 - 253,001,302UniSTS
RH 3.4 Map11690.1UniSTS
Cytogenetic Map1q55UniSTS
Gfra1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21257,549,390 - 257,550,528 (+)MAPPERmRatBN7.2
Rnor_6.01279,571,144 - 279,572,281NCBIRnor6.0
Rnor_6.01278,478,808 - 278,479,945NCBIRnor6.0
Rnor_5.01285,849,673 - 285,850,810UniSTSRnor5.0
Rnor_5.01286,933,409 - 286,934,546UniSTSRnor5.0
RGSC_v3.41264,874,094 - 264,875,231UniSTSRGSC3.4
Celera1253,228,025 - 253,229,162UniSTS
Cytogenetic Map1q55UniSTS
Gfra1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21257,549,390 - 257,550,527 (+)MAPPERmRatBN7.2
Rnor_6.01279,571,144 - 279,572,280NCBIRnor6.0
Rnor_6.01278,478,808 - 278,479,944NCBIRnor6.0
Rnor_5.01285,849,673 - 285,850,809UniSTSRnor5.0
Rnor_5.01286,933,409 - 286,934,545UniSTSRnor5.0
RGSC_v3.41264,874,094 - 264,875,230UniSTSRGSC3.4
Celera1253,228,025 - 253,229,161UniSTS
Cytogenetic Map1q55UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
hemolymphoid system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
sensory system
visual system
7 1 18 44 2 73 30 11 43 36 32 15 15

Sequence


Ensembl Acc Id: ENSRNOT00000023667   ⟹   ENSRNOP00000023667
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1267,326,817 - 267,556,501 (-)Ensembl
mRatBN7.2 Ensembl1257,321,742 - 257,551,473 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000104357   ⟹   ENSRNOP00000091515
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1267,326,817 - 267,556,501 (-)Ensembl
mRatBN7.2 Ensembl1257,321,742 - 257,551,473 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000119102   ⟹   ENSRNOP00000091664
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1257,321,742 - 257,551,473 (-)Ensembl
RefSeq Acc Id: NM_012959   ⟹   NP_037091
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81267,325,297 - 267,555,811 (-)NCBI
mRatBN7.21257,320,222 - 257,550,783 (-)NCBI
Rnor_6.01279,207,586 - 279,572,536 (-)NCBI
Rnor_5.01286,571,283 - 286,640,993 (-)NCBI
Rnor_5.01286,932,096 - 286,934,801 (-)NCBI
RGSC_v3.41264,614,329 - 264,875,486 (-)RGD
Celera1253,001,051 - 253,229,417 (-)RGD
Sequence:
RefSeq Acc Id: XM_008760512   ⟹   XP_008758734
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81267,325,297 - 267,556,077 (-)NCBI
mRatBN7.21257,315,682 - 257,551,042 (-)NCBI
Rnor_6.01279,203,046 - 279,572,789 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008760514   ⟹   XP_008758736
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81267,325,297 - 267,556,516 (-)NCBI
mRatBN7.21257,315,682 - 257,551,498 (-)NCBI
Rnor_6.01279,203,046 - 279,572,595 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039101759   ⟹   XP_038957687
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81267,325,297 - 267,556,516 (-)NCBI
mRatBN7.21257,315,682 - 257,551,498 (-)NCBI
RefSeq Acc Id: XM_039101762   ⟹   XP_038957690
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81267,325,297 - 267,556,524 (-)NCBI
mRatBN7.21257,315,682 - 257,551,523 (-)NCBI
RefSeq Acc Id: XM_039101768   ⟹   XP_038957696
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81267,325,297 - 267,557,037 (-)NCBI
mRatBN7.21257,315,682 - 257,552,004 (-)NCBI
RefSeq Acc Id: XM_063281839   ⟹   XP_063137909
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81267,325,297 - 267,556,524 (-)NCBI
RefSeq Acc Id: XM_063281844   ⟹   XP_063137914
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81267,325,297 - 267,557,036 (-)NCBI
RefSeq Acc Id: NP_037091   ⟸   NM_012959
- Peptide Label: precursor
- UniProtKB: Q62997 (UniProtKB/Swiss-Prot),   A6JI59 (UniProtKB/TrEMBL),   A0A0A0MXY7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008758734   ⟸   XM_008760512
- Peptide Label: isoform X1
- UniProtKB: Q62997 (UniProtKB/Swiss-Prot),   A6JI59 (UniProtKB/TrEMBL),   A0A0A0MXY7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008758736   ⟸   XM_008760514
- Peptide Label: isoform X2
- UniProtKB: O35748 (UniProtKB/TrEMBL),   A6JI55 (UniProtKB/TrEMBL),   A0A0A0MXY7 (UniProtKB/TrEMBL),   A6JI56 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_038957696   ⟸   XM_039101768
- Peptide Label: isoform X1
- UniProtKB: Q62997 (UniProtKB/Swiss-Prot),   A6JI59 (UniProtKB/TrEMBL),   A0A0A0MXY7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038957690   ⟸   XM_039101762
- Peptide Label: isoform X1
- UniProtKB: Q62997 (UniProtKB/Swiss-Prot),   A6JI59 (UniProtKB/TrEMBL),   A0A0A0MXY7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038957687   ⟸   XM_039101759
- Peptide Label: isoform X1
- UniProtKB: Q62997 (UniProtKB/Swiss-Prot),   A6JI59 (UniProtKB/TrEMBL),   A0A0A0MXY7 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000023667   ⟸   ENSRNOT00000023667
Ensembl Acc Id: ENSRNOP00000091664   ⟸   ENSRNOT00000119102
Ensembl Acc Id: ENSRNOP00000091515   ⟸   ENSRNOT00000104357
RefSeq Acc Id: XP_063137914   ⟸   XM_063281844
- Peptide Label: isoform X2
- UniProtKB: A0A0A0MXY7 (UniProtKB/TrEMBL),   A6JI55 (UniProtKB/TrEMBL),   A6JI56 (UniProtKB/TrEMBL),   O35748 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063137909   ⟸   XM_063281839
- Peptide Label: isoform X2
- UniProtKB: A0A0A0MXY7 (UniProtKB/TrEMBL),   A6JI55 (UniProtKB/TrEMBL),   A6JI56 (UniProtKB/TrEMBL),   O35748 (UniProtKB/TrEMBL)
Protein Domains
GDNF/GAS1

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0A0A0MXY7-F1-model_v2 AlphaFold A0A0A0MXY7 1-343 view protein structure
AF-Q62997-F1-model_v2 AlphaFold Q62997 1-468 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2681 AgrOrtholog
BioCyc Gene G2FUF-55276 BioCyc
Ensembl Genes ENSRNOG00000017438 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000023667 ENTREZGENE
  ENSRNOT00000104357 ENTREZGENE
  ENSRNOT00000119102.1 UniProtKB/Swiss-Prot
Gene3D-CATH GDNF binding domain UniProtKB/Swiss-Prot
InterPro GDNF/GAS1 UniProtKB/Swiss-Prot
  GDNF_alpha UniProtKB/Swiss-Prot
  GDNF_rcpt UniProtKB/Swiss-Prot
  GDNF_rcpt_A1 UniProtKB/Swiss-Prot
  Glial_neurotroph_fac_rcpt_a1/2 UniProtKB/Swiss-Prot
KEGG Report rno:25454 UniProtKB/Swiss-Prot
NCBI Gene 25454 ENTREZGENE
PANTHER GDNF FAMILY RECEPTOR ALPHA-1 UniProtKB/Swiss-Prot
  PTHR10269 UniProtKB/Swiss-Prot
Pfam GDNF UniProtKB/Swiss-Prot
PhenoGen Gfra1 PhenoGen
PIRSF GDNF_family_receptor_alpha UniProtKB/Swiss-Prot
PRINTS GDNFRALPHA1 UniProtKB/Swiss-Prot
  GDNFRECEPTOR UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000017438 RatGTEx
SMART GDNF UniProtKB/Swiss-Prot
Superfamily-SCOP SSF110035 UniProtKB/Swiss-Prot
TIGR TC218224
  TC227846
UniProt A0A0A0MXY7 ENTREZGENE, UniProtKB/TrEMBL
  A6JI55 ENTREZGENE, UniProtKB/TrEMBL
  A6JI56 ENTREZGENE, UniProtKB/TrEMBL
  A6JI59 ENTREZGENE, UniProtKB/TrEMBL
  GFRA1_RAT UniProtKB/Swiss-Prot
  O35748 ENTREZGENE
  Q62997 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Gfra1  GDNF family receptor alpha 1  LOC100911751  GDNF family receptor alpha-1-like  Data merged from RGD:6490816 737654 PROVISIONAL
2012-07-05 LOC100911751  GDNF family receptor alpha-1-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2008-10-17 Gfra1  GDNF family receptor alpha 1  Gfra1  glial cell line derived neurotrophic factor family receptor alpha 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-11-06 Gfra1  glial cell line derived neurotrophic factor family receptor alpha 1    Glial cell line-derived neurotrophic factor receptor alpha  Name updated 625702 APPROVED
2002-06-10 Gfra1  Glial cell line-derived neurotrophic factor receptor alpha      Symbol and Name status set to approved 70586 APPROVED