Fabp1 (fatty acid binding protein 1) - Rat Genome Database

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Gene: Fabp1 (fatty acid binding protein 1) Rattus norvegicus
Analyze
Symbol: Fabp1
Name: fatty acid binding protein 1
RGD ID: 2590
Description: Enables several functions, including long-chain fatty acid transmembrane transporter activity; monocarboxylic acid binding activity; and phospholipid binding activity. Involved in several processes, including long-chain fatty acid transport; positive regulation of fatty acid beta-oxidation; and response to vitamin B3. Located in apical cortex and peroxisomal matrix. Part of protein-containing complex. Biomarker of end stage renal disease. Orthologous to human FABP1 (fatty acid binding protein 1); PARTICIPATES IN eicosanoid signaling pathway via peroxisome proliferator-activated receptor gamma; INTERACTS WITH (+)-schisandrin B; 1,2-dimethylhydrazine; 1-naphthyl isothiocyanate.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Fabplg; Fatty acid binding protein 1 liver; fatty acid binding protein 1, liver; fatty acid-binding protein 1; fatty acid-binding protein, liver; fatty-acid-binding protein; L-FABP; liver-type fatty acid-binding protein; MGC108756; p14; RATFABPLG; SCP; SCP.; squalene- and sterol-carrier protein; Z-protein
RGD Orthologs
Human
Mouse
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Is Marker For: Strains:   BB.WOKW-(D4Got41-Fabp1)/K  
QTLs:   Bw53  
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84104,744,302 - 104,753,119 (+)NCBIGRCr8
mRatBN7.24103,191,015 - 103,194,791 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4103,191,006 - 103,194,788 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4108,579,494 - 108,583,270 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04104,354,593 - 104,358,369 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04102,960,918 - 102,964,694 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0499,063,181 - 99,066,957 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl499,063,181 - 99,066,954 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04163,840,329 - 163,844,105 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44104,412,200 - 104,415,981 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.14104,656,680 - 104,660,462 (+)NCBI
Celera492,366,948 - 92,370,724 (+)NCBICelera
Cytogenetic Map4q32NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
1,2-dimethylhydrazine  (EXP,ISO)
1-[(4-chlorophenyl)-phenylmethyl]-4-methylpiperazine  (ISO)
1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carbonitrile  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
1-naphthyl isothiocyanate  (EXP)
11-hydroxy-Delta(9)-tetrahydrocannabinol  (EXP,ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2-arachidonoylglycerol  (ISO)
2-oleoylglycerol  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
4-(ethoxymethylene)-2-phenyloxazol-5-one  (ISO)
5-Hydroxythalidomide  (ISO)
6-(4-chlorophenyl)imidazo[2,1-b][1,3]thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime  (ISO)
8-Br-cAMP  (ISO)
acetamide  (EXP)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (ISO)
amiodarone  (ISO)
amitriptyline  (ISO)
ammonium chloride  (EXP)
anandamide  (EXP,ISO)
anthracen-2-amine  (EXP)
arotinoid acid  (ISO)
azathioprine  (ISO)
belinostat  (ISO)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
benzylpenicillin  (ISO)
beta-lapachone  (ISO)
bexarotene  (EXP)
bezafibrate  (EXP,ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bosentan  (ISO)
bromobenzene  (EXP)
buta-1,3-diene  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
cannabidiol  (ISO)
captan  (ISO)
carbon nanotube  (ISO)
carnosic acid  (ISO)
CHIR 99021  (ISO)
chloroform  (EXP)
chloroprene  (ISO)
chlorothalonil  (ISO)
chlorpromazine  (ISO)
cholesterol  (EXP)
choline  (ISO)
ciglitazone  (ISO)
ciprofibrate  (EXP,ISO)
cisplatin  (EXP,ISO)
citalopram  (ISO)
clofibrate  (EXP,ISO)
Clofop  (ISO)
clomipramine  (ISO)
clozapine  (ISO)
cobalt dichloride  (EXP,ISO)
copper(II) sulfate  (ISO)
corn oil  (EXP)
cortisol  (ISO)
cyclosporin A  (EXP,ISO)
cylindrospermopsin  (ISO)
D-glucose  (ISO)
DAUDA  (ISO)
DDE  (ISO)
dehydroepiandrosterone sulfate  (ISO)
dexamethasone  (EXP)
dibenz[a,h]anthracene  (ISO)
dibenzo[a,l]pyrene  (ISO)
dibutyl phthalate  (ISO)
dichlorine  (EXP)
dichloroacetic acid  (ISO)
diclofenac  (ISO)
dicoumarol  (EXP)
dicrotophos  (ISO)
diethyl maleate  (EXP)
difenoconazole  (ISO)
dimethylarsinic acid  (ISO)
dioxygen  (ISO)
dipentyl phthalate  (EXP)
diquat  (ISO)
doxepin  (ISO)
entinostat  (ISO)
erythromycin A  (ISO)
erythromycin estolate  (EXP)
ethanol  (EXP,ISO)
farnesol  (ISO)
fenofibrate  (EXP,ISO)
flecainide  (ISO)
fluoranthene  (ISO)
fluoxetine  (ISO)
folic acid  (ISO)
folpet  (ISO)
fumonisin B1  (ISO)
furan  (EXP)
genistein  (ISO)
glucose  (ISO)
glyphosate  (ISO)
griseofulvin  (ISO)
GW 4064  (ISO)
GW 501516  (ISO)
GW 7647  (EXP,ISO)
hexadecanoic acid  (ISO)
hydrazine  (EXP)
hydrogen peroxide  (ISO)
imipramine  (ISO)
indometacin  (EXP)
irinotecan  (EXP)
ketoconazole  (EXP,ISO)
L-ascorbic acid  (ISO)
L-ascorbic acid 2-phosphate  (ISO)
L-methionine  (ISO)
Lasiocarpine  (ISO)
linalool  (ISO)
linoleic acid  (ISO)
lipopolysaccharide  (ISO)
loratadine  (ISO)
LY294002  (ISO)
menadione  (ISO)
methapyrilene  (EXP,ISO)
methotrexate  (EXP,ISO)
methylarsonic acid  (ISO)
methylmercury chloride  (ISO)
microcystin-LR  (ISO)
Muraglitazar  (EXP)
N-nitrosodiethylamine  (EXP)
N-nitrosodimethylamine  (ISO)
N-nitrosomorpholine  (EXP)
N-Nitrosopyrrolidine  (ISO)
nickel dichloride  (EXP)
nicotinamide  (EXP)
nicotinic acid  (EXP)
nitrofen  (EXP)
Nor-9-carboxy-delta9-THC  (EXP,ISO)
O-methyleugenol  (ISO)
olanzapine  (ISO)
oleic acid  (EXP,ISO)
orlistat  (ISO)
ozone  (EXP,ISO)
paclitaxel  (ISO)
paracetamol  (EXP,ISO)
pentamidine  (ISO)
perflubutane  (ISO)
perfluorobutyric acid  (ISO)
perfluorodecanoic acid  (ISO)
perfluorododecanoic acid  (ISO)
perfluoroheptanoic acid  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorohexanoic acid  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (EXP,ISO)
perfluoropentanoic acid  (ISO)
perfluoroundecanoic acid  (ISO)
perhexiline  (ISO)
phenobarbital  (EXP)
phytanic acid  (ISO)
pirinixic acid  (EXP,ISO)
potassium dichromate  (ISO)
pravastatin  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
Primycin  (ISO)
procymidone  (ISO)
Propiverine  (EXP)
pyrazinecarboxamide  (EXP)
quercetin  (ISO)
quinidine  (ISO)
rotenone  (EXP)
sarpogrelate  (ISO)
SB 431542  (ISO)
sertraline  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium cholate  (EXP)
sodium dichromate  (EXP,ISO)
spermine  (ISO)
sulindac sulfide  (ISO)
tamoxifen  (EXP,ISO)
Tesaglitazar  (EXP,ISO)
tetrachloroethene  (ISO)
tetrachloromethane  (EXP)
tetracycline  (EXP,ISO)
tetraphene  (ISO)
theophylline  (EXP)
thioacetamide  (EXP)
thioridazine  (ISO)
titanium dioxide  (ISO)
toluene 2,4-diisocyanate  (ISO)
trichloroethene  (ISO)
trimellitic anhydride  (ISO)
Triptolide  (ISO)
troglitazone  (EXP,ISO)
urethane  (ISO)
valproic acid  (EXP,ISO)
warfarin  (EXP)
XAV939  (ISO)
zaragozic acid A  (EXP,ISO)
zearalenone  (ISO)
zimeldine  (ISO)
zinc atom  (EXP,ISO)
zinc dichloride  (ISO)
zinc(0)  (EXP,ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. Intestinal fatty acid binding protein may favor differential apical fatty acid binding in the intestine. Alpers DH, etal., Biochim Biophys Acta. 2000 Jan 31;1483(3):352-62.
2. Localization of a portion of the liver isoform of fatty-acid-binding protein (L-FABP) to peroxisomes. Antonenkov VD, etal., Biochem J. 2006 Mar 1;394(Pt 2):475-84.
3. Liver fatty acid binding protein is the mitosis-associated polypeptide target of a carcinogen in rat hepatocytes. Bassuk JA, etal., Proc Natl Acad Sci U S A 1987 Nov;84(21):7547-51.
4. Niacin improves renal lipid metabolism and slows progression in chronic kidney disease. Cho KH, etal., Biochim Biophys Acta. 2010 Jan;1800(1):6-15. Epub 2009 Oct 28.
5. The alpha-helical domain of liver fatty acid binding protein is responsible for the diffusion-mediated transfer of fatty acids to phospholipid membranes. Corsico B, etal., Biochemistry. 2004 Mar 30;43(12):3600-7.
6. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
7. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
8. Analyzing the structures, functions and evolution of two abundant gastrointestinal fatty acid binding proteins with recombinant DNA and computational techniques. Gordon JI and Lowe JB, Chem Phys Lipids 1985 Aug 30;38(1-2):137-58.
9. The nucleotide sequence of rat liver fatty acid binding protein mRNA. Gordon JI, etal., J Biol Chem 1983 Mar 10;258(5):3356-63.
10. The effect of charge reversal mutations in the alpha-helical region of liver fatty acid binding protein on the binding of fatty-acyl CoAs, lysophospholipids and bile acids. Hagan RM, etal., Mol Cell Biochem. 2002 Oct;239(1-2):55-60.
11. Urinary excretion of liver fatty acid-binding protein in health-check participants. Ishimitsu T, etal., Clin Exp Nephrol. 2005 Mar;9(1):34-9.
12. Translational control of the circadian rhythm of liver sterol carrier protein. Analysis of mRNA sequences with a specific cDNA probe. McGuire DM, etal., J Biol Chem 1985 May 10;260(9):5435-9.
13. Liver-type fatty acid binding protein interacts with hepatocyte nuclear factor 4alpha. McIntosh AL, etal., FEBS Lett. 2013 Nov 29;587(23):3787-91. doi: 10.1016/j.febslet.2013.09.043. Epub 2013 Oct 15.
14. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
15. Identification by photoaffinity labeling of fatty acid-binding protein as a potential warfarin receptor in rat liver. Myszka DG and Swenson RP, J Biol Chem. 1991 Nov 5;266(31):20725-31.
16. Urinary liver-type fatty acid-binding protein: discrimination between IgA nephropathy and thin basement membrane nephropathy. Nakamura T, etal., Am J Nephrol. 2005 Sep-Oct;25(5):447-50. Epub 2005 Aug 23.
17. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
18. Protection against Western diet-induced obesity and hepatic steatosis in liver fatty acid-binding protein knockout mice. Newberry EP, etal., Hepatology. 2006 Nov;44(5):1191-205.
19. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
20. GOA pipeline RGD automated data pipeline
21. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
22. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
23. Phosphorylation of Sar1b protein releases liver fatty acid-binding protein from multiprotein complex in intestinal cytosol enabling it to bind to endoplasmic reticulum (ER) and bud the pre-chylomicron transport vesicle. Siddiqi S and Mansbach CM 2nd, J Biol Chem. 2012 Mar 23;287(13):10178-88. doi: 10.1074/jbc.M111.327247. Epub 2012 Feb 1.
24. The nucleotide sequence of the rat liver fatty acid-binding protein gene. Evidence that exon 1 encodes an oligopeptide domain shared by a family of proteins which bind hydrophobic ligands. Sweetser DA, etal., J Biol Chem 1986 Apr 25;261(12):5553-61.
25. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
26. The crystal structure of the liver fatty acid-binding protein. A complex with two bound oleates. Thompson J, etal., J Biol Chem. 1997 Mar 14;272(11):7140-50.
27. Enhanced expression of cytosolic fatty acid binding protein and fatty acid uptake during liver regeneration in rats. Wang G, etal., Mol Cell Biochem. 2004 Jul;262(1-2):41-9.
Additional References at PubMed
PMID:1898328   PMID:6641731   PMID:7084456   PMID:8117116   PMID:12477932   PMID:15489334   PMID:15522233   PMID:16175609   PMID:16396499   PMID:16603485   PMID:16940177   PMID:16950764  
PMID:17272516   PMID:17449472   PMID:17551764   PMID:17927211   PMID:19056867   PMID:20628144   PMID:21102658   PMID:21226535   PMID:23376485   PMID:23533145   PMID:23658011   PMID:27117865  
PMID:32405506   PMID:37076661  


Genomics

Comparative Map Data
Fabp1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84104,744,302 - 104,753,119 (+)NCBIGRCr8
mRatBN7.24103,191,015 - 103,194,791 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4103,191,006 - 103,194,788 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4108,579,494 - 108,583,270 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04104,354,593 - 104,358,369 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04102,960,918 - 102,964,694 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0499,063,181 - 99,066,957 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl499,063,181 - 99,066,954 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04163,840,329 - 163,844,105 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44104,412,200 - 104,415,981 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.14104,656,680 - 104,660,462 (+)NCBI
Celera492,366,948 - 92,370,724 (+)NCBICelera
Cytogenetic Map4q32NCBI
FABP1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38288,122,982 - 88,128,062 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl288,122,982 - 88,128,062 (-)EnsemblGRCh38hg38GRCh38
GRCh37288,422,501 - 88,427,581 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36288,203,625 - 88,208,693 (-)NCBINCBI36Build 36hg18NCBI36
Build 34288,261,771 - 88,266,840NCBI
Celera288,358,422 - 88,363,490 (+)NCBICelera
Cytogenetic Map2p11.2NCBI
HuRef287,344,752 - 87,349,901 (-)NCBIHuRef
CHM1_1288,351,787 - 88,356,936 (-)NCBICHM1_1
T2T-CHM13v2.0288,134,227 - 88,181,784 (-)NCBIT2T-CHM13v2.0
Fabp1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39671,176,863 - 71,182,018 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl671,176,811 - 71,182,007 (+)EnsemblGRCm39 Ensembl
GRCm38671,199,879 - 71,205,034 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl671,199,827 - 71,205,023 (+)EnsemblGRCm38mm10GRCm38
MGSCv37671,149,882 - 71,155,017 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36671,129,467 - 71,134,602 (+)NCBIMGSCv36mm8
Celera673,279,169 - 73,284,304 (+)NCBICelera
Cytogenetic Map6C1NCBI
cM Map632.14NCBI
FABP1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21239,132,205 - 39,179,712 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12A39,134,991 - 39,182,472 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02A87,256,032 - 87,303,505 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12A89,165,308 - 89,170,448 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A89,165,315 - 89,170,448 (-)Ensemblpanpan1.1panPan2
FABP1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11738,242,119 - 38,247,969 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1738,242,119 - 38,247,962 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1737,927,199 - 37,933,049 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01738,974,817 - 38,980,672 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1738,974,817 - 38,980,665 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11738,141,305 - 38,147,138 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01738,177,707 - 38,183,562 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01738,525,592 - 38,531,443 (+)NCBIUU_Cfam_GSD_1.0
Fabp1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629280,115,372 - 80,120,099 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936712738,348 - 743,955 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936712738,361 - 743,073 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FABP1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl357,850,499 - 57,854,956 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1357,850,511 - 57,854,966 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2360,622,675 - 60,627,082 (-)NCBISscrofa10.2Sscrofa10.2susScr3
FABP1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11418,660,058 - 18,666,730 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1418,659,836 - 18,667,127 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660801,109,470 - 1,116,478 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in Fabp1
18 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:70
Count of miRNA genes:59
Interacting mature miRNAs:63
Transcripts:ENSRNOT00000008840
Prediction methods:Microtar, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1582232Gluco25Glucose level QTL 253.60.0023blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)485253748148090731Rat
631689Scl4Serum cholesterol level QTL 41.90.008blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)495174120140174120Rat
1358352Srcrt3Stress Responsive Cort QTL 32.29blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)438465774146803430Rat
1549843Bw53Body weight QTL 530.0001body mass (VT:0001259)body weight gain (CMO:0000420)461697658103194791Rat
1578655Bmd11Bone mineral density QTL 1111femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)490850165135850165Rat
10755501Bp390Blood pressure QTL 3902.5arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)426775591168368347Rat
1357342Bw40Body weight QTL 400.001body mass (VT:0001259)body weight (CMO:0000012)476647384117676292Rat
631556Bp135Blood pressure QTL 1350.017arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)478881294117676292Rat
61330Eau1Experimental allergic uveoretinitis QTL 10.0003uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)470362013132642728Rat
70167Bw22Body weight QTL 223.1body mass (VT:0001259)body weight (CMO:0000012)476647384117676292Rat
1549839Bw52Body weight QTL 520.0001body mass (VT:0001259)body weight gain (CMO:0000420)461697658115089733Rat
70177Xhs1X-ray hypersensitivity QTL 125.1intestine integrity trait (VT:0010554)post-insult time to onset of moribundity (CMO:0001896)482798864152731274Rat
724522Bp146Blood pressure QTL 1462.20.0021arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)473630210118630210Rat
61476Aia3Adjuvant induced arthritis QTL 33.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)486730991131730991Rat
1641919Alc22Alcohol consumption QTL 220.0005drinking behavior trait (VT:0001422)ethanol drink intake rate (CMO:0001407)481192555126192555Rat
1354660Salc1Saline consumption QTL 111.26drinking behavior trait (VT:0001422)saline drink intake rate (CMO:0001627)444463908148090542Rat
2300179Bmd50Bone mineral density QTL 505.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)460928534105928534Rat
2317587Eae26Experimental allergic encephalomyelitis QTL 26nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)488656681103194984Rat
1298082Stresp4Stress response QTL 4blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)450119848146803430Rat
70192BpQTLcluster5Blood pressure QTL cluster 54.183arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)462933508114921294Rat
1578670Bss14Bone structure and strength QTL 1416.4femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)487327165132327165Rat
1300139Hrtrt6Heart rate QTL 62.85heart pumping trait (VT:2000009)heart rate (CMO:0000002)439524264116179656Rat
70200Alc18Alcohol consumption QTL 189.2drinking behavior trait (VT:0001422)ethanol intake volume to total fluid intake volume ratio (CMO:0001591)456647873149491524Rat
1578657Bss12Bone structure and strength QTL 128.9femur morphology trait (VT:0000559)femoral neck cross-sectional area (CMO:0001697)460220938105220938Rat
1578658Bss13Bone structure and strength QTL 138femur strength trait (VT:0010010)femoral neck polar moment of inertia (CMO:0001670)460220938105220938Rat
2316958Gluco58Glucose level QTL 5810blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)411320076180699135Rat
6478684Anxrr30Anxiety related response QTL 300.00087defecation behavior trait (VT:0010462)defecation rate (CMO:0000998)462753847107753847Rat
1578662Bss15Bone structure and strength QTL 1519.6femur width (VT:1000666)femoral neck width (CMO:0001695)487327165132327165Rat
2302051Pia28Pristane induced arthritis QTL 285.30.001blood autoantibody amount (VT:0003725)serum immunoglobulin G-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002112)473630210118630210Rat
8662350Eae35Experimental allergic encephalomyelitis QTL 356.2blood tumor necrosis factor amount (VT:0008552)inflammatory exudate tumor necrosis factor level (CMO:0001435)4100834579103761084Rat
738009Sach4Saccharine consumption QTL 44.90.000016consumption behavior trait (VT:0002069)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)459948935154902892Rat
2312567Glom19Glomerulus QTL 191.90.006kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)445456990146803430Rat
738015Pia9Pristane induced arthritis QTL 94.50.048joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)480694870125694870Rat
6478772Anxrr49Anxiety related response QTL 490.15488defecation behavior trait (VT:0010462)defecation rate (CMO:0000998)462753847107753847Rat
634335Anxrr16Anxiety related response QTL 167.22locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)493308457167139447Rat
631646Stl4Serum triglyceride level QTL 46.50.0001blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)473169846132642728Rat
634334Xhs3X-ray hypersensitivity QTL 310intestine integrity trait (VT:0010554)post-insult time to onset of moribundity (CMO:0001896)484728680129854654Rat
8655961Kidm43Kidney mass QTL 4318kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)436303261103194984Rat
1354612Foco1Food consumption QTL 18.87eating behavior trait (VT:0001431)food intake rate (CMO:0000427)444463908148090542Rat
634344Hcar7Hepatocarcinoma resistance QTL 77.8liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)470808386115808386Rat
2303168Bp330Blood pressure QTL 3304.250.017arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)45214602146446691Rat
738031Alc14Alcohol consumption QTL 147.60.00003consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)459948935154902892Rat
1576316Ept5Estrogen-induced pituitary tumorigenesis QTL 53.8pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)483428419177635233Rat
631662Hcar2Hepatocarcinoma resistance QTL 23.10.0003liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)478878504123878504Rat
1576305Emca6Estrogen-induced mammary cancer QTL 65.8mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)444463720155883716Rat
61418Pia5Pristane induced arthritis QTL 54.5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)462277855128289560Rat
631651Bp124Blood pressure QTL 1243arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)462879517107879517Rat
738016Alc16Alcohol consumption QTL 163.60.00015consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)459948935154902892Rat
1358202Gluco11Glucose level QTL 112.40.02adipocyte glucose uptake trait (VT:0004185)absolute change in adipocyte glucose uptake (CMO:0000873)485379421167139601Rat
1641833Alc21Alcohol consumption QTL 218.60.0001drinking behavior trait (VT:0001422)ethanol drink intake rate (CMO:0001407)456698790126192555Rat
2306899Bp338Blood pressure QTL 3380.071arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)481006124120102625Rat
631674Iddm14Insulin dependent diabetes mellitus QTL 14blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)464528739157573521Rat
6478743Anxrr40Anxiety related response QTL 400.83076defecation behavior trait (VT:0010462)defecation rate (CMO:0000998)462753847107753847Rat
12798523Anxrr56Anxiety related response QTL 562.830.05locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)485253748150276390Rat
61434Cia3Collagen induced arthritis QTL 34.8joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4103194656148194656Rat
12798520Anxrr55Anxiety related response QTL 554.450.01locomotor behavior trait (VT:0001392)number of rearing movements with lid-pushing in an experimental apparatus (CMO:0002715)432583980114627242Rat

Markers in Region
D4Mit12  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24103,194,805 - 103,194,984 (+)MAPPERmRatBN7.2
Rnor_6.0499,066,972 - 99,067,150NCBIRnor6.0
Rnor_5.04163,844,120 - 163,844,298UniSTSRnor5.0
RGSC_v3.44104,415,992 - 104,416,171RGDRGSC3.4
RGSC_v3.44104,415,993 - 104,416,171UniSTSRGSC3.4
RGSC_v3.14104,660,473 - 104,660,652RGD
Celera492,370,739 - 92,370,917UniSTS
SHRSP x BN Map448.75UniSTS
SHRSP x BN Map448.75RGD
FHH x ACI Map460.18RGD
Cytogenetic Map4q32UniSTS
D4Wox20  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24103,194,798 - 103,194,942 (+)MAPPERmRatBN7.2
Rnor_6.0499,066,965 - 99,067,108NCBIRnor6.0
Rnor_5.04163,844,113 - 163,844,256UniSTSRnor5.0
RGSC_v3.44104,415,985 - 104,416,129RGDRGSC3.4
RGSC_v3.44104,415,986 - 104,416,129UniSTSRGSC3.4
Celera492,370,732 - 92,370,875UniSTS
Cytogenetic Map4q32UniSTS
D4Arb21  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24103,194,656 - 103,194,936 (+)MAPPERmRatBN7.2
Rnor_6.0499,066,823 - 99,067,102NCBIRnor6.0
Rnor_5.04163,843,971 - 163,844,250UniSTSRnor5.0
RGSC_v3.44104,415,843 - 104,416,123RGDRGSC3.4
RGSC_v3.44104,415,844 - 104,416,123UniSTSRGSC3.4
RGSC_v3.14104,660,324 - 104,660,604RGD
Celera492,370,590 - 92,370,869UniSTS
Cytogenetic Map4q32UniSTS


Related Rat Strains
The following Strains have been annotated to Fabp1
BB.WOKW-(D4Got41-Fabp1)/K    


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 23 48 86 85 59 19 59 6 178 62 31 40 42 26

Sequence


Ensembl Acc Id: ENSRNOT00000008840   ⟹   ENSRNOP00000008841
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl4103,191,006 - 103,194,788 (+)Ensembl
Rnor_6.0 Ensembl499,063,181 - 99,066,954 (+)Ensembl
RefSeq Acc Id: NM_012556   ⟹   NP_036688
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84104,749,340 - 104,753,116 (+)NCBI
mRatBN7.24103,191,015 - 103,194,791 (+)NCBI
Rnor_6.0499,063,181 - 99,066,957 (+)NCBI
Rnor_5.04163,840,329 - 163,844,105 (+)NCBI
RGSC_v3.44104,412,200 - 104,415,981 (+)RGD
Celera492,366,948 - 92,370,724 (+)NCBI
Sequence:
RefSeq Acc Id: XM_063285516   ⟹   XP_063141586
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84104,744,302 - 104,753,119 (+)NCBI
RefSeq Acc Id: NP_036688   ⟸   NM_012556
- UniProtKB: P02692 (UniProtKB/Swiss-Prot),   A6IA66 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000008841   ⟸   ENSRNOT00000008840
RefSeq Acc Id: XP_063141586   ⟸   XM_063285516
- Peptide Label: isoform X1
- UniProtKB: P02692 (UniProtKB/Swiss-Prot),   A6IA66 (UniProtKB/TrEMBL)
Protein Domains
Cytosolic fatty-acid binding proteins

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P02692-F1-model_v2 AlphaFold P02692 1-127 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13693109
Promoter ID:EPDNEW_R3634
Type:multiple initiation site
Name:Fabp1_1
Description:fatty acid binding protein 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0499,063,171 - 99,063,231EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2590 AgrOrtholog
BioCyc Gene G2FUF-44192 BioCyc
Ensembl Genes ENSRNOG00000006675 Ensembl, UniProtKB/Swiss-Prot
  ENSRNOG00055020309 UniProtKB/Swiss-Prot
  ENSRNOG00060014485 UniProtKB/Swiss-Prot
  ENSRNOG00065001537 UniProtKB/Swiss-Prot
  ENSRNOG00065005164 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000008840.6 UniProtKB/Swiss-Prot
  ENSRNOT00055034684 UniProtKB/Swiss-Prot
  ENSRNOT00060024759 UniProtKB/Swiss-Prot
  ENSRNOT00065002062 UniProtKB/Swiss-Prot
  ENSRNOT00065007566 UniProtKB/Swiss-Prot
Gene3D-CATH 2.40.128.20 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7325407 IMAGE-MGC_LOAD
InterPro Calycin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Fatty_acid-bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ILBP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:24360 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:108756 IMAGE-MGC_LOAD
NCBI Gene 24360 ENTREZGENE
PANTHER FATTY ACID BINDING PROTEIN UniProtKB/TrEMBL
  FATTY ACID-BINDING PROTEIN, LIVER UniProtKB/TrEMBL
  PTHR11955 UniProtKB/Swiss-Prot
  PTHR11955:SF96 UniProtKB/Swiss-Prot
Pfam Lipocalin_7 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Fabp1 PhenoGen
PRINTS FATTYACIDBP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE FABP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000006675 RatGTEx
  ENSRNOG00055020309 RatGTEx
  ENSRNOG00060014485 RatGTEx
  ENSRNOG00065001537 RatGTEx
  ENSRNOG00065005164 RatGTEx
Superfamily-SCOP Lipocalins UniProtKB/TrEMBL, UniProtKB/Swiss-Prot
TIGR TC232636
UniProt A6IA66 ENTREZGENE, UniProtKB/TrEMBL
  FABPL_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-01-27 Fabp1  fatty acid binding protein 1  Fabp1  fatty acid binding protein 1, liver  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Fabp1  fatty acid binding protein 1, liver    fatty acid binding protein 1  Name updated 1299863 APPROVED
2002-06-10 Fabp1  Fatty acid binding protein 1, liver      Symbol and Name status set to approved 70586 APPROVED