Advanced Search (OLGA)

Gene: Stx2 (syntaxin 2) Rattus norvegicus

Analyze

Symbol:

Stx2

Name:

syntaxin 2

RGD ID:

2558

Description:

Enables SNARE binding activity. Involved in several processes, including digestive tract morphogenesis; microvillus assembly; and midbody abscission. Located in midbody. Is active in synapse. Orthologous to human STX2 (syntaxin 2); INTERACTS WITH (+)-schisandrin B; 2,3,7,8-tetrachlorodibenzodioxine; 2-ethoxyethanol.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

Epim; epimorphin; syntaxin-2

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	STX2 (syntaxin 2)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):	Stx2 (syntaxin 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Stx2 (syntaxin 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	STX2 (syntaxin 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	STX2 (syntaxin 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Stx2 (syntaxin 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	STX2 (syntaxin 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	STX2 (syntaxin 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Stx2 (syntaxin 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus rattus (black rat):	Stx2 (syntaxin 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Mus musculus (house mouse):	Stx2 (syntaxin 2)	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Homo sapiens (human):	STX2 (syntaxin 2)	Alliance	DIOPT (HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	stx2a (syntaxin 2a)	Alliance	DIOPT (OrthoFinder\|PANTHER\|PhylomeDB)
Danio rerio (zebrafish):	stx2b (syntaxin 2b)	Alliance	DIOPT (Hieranoid\|OMA\|OrthoFinder\|PANTHER\|PhylomeDB)
Danio rerio (zebrafish):	stx2b (syntaxin 2b)	Alliance	DIOPT (Hieranoid\|OMA\|OrthoFinder\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	Syx1A	Alliance	DIOPT (Hieranoid\|OrthoFinder\|PANTHER\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	SSO1	Alliance	DIOPT (InParanoid\|OMA\|OrthoFinder\|PANTHER\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	SSO1	Alliance	DIOPT (InParanoid\|OMA\|OrthoInspector\|PANTHER)
Saccharomyces cerevisiae (baker's yeast):	SSO2	Alliance	DIOPT (InParanoid\|OMA\|OrthoFinder\|PANTHER\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	SSO2	Alliance	DIOPT (InParanoid\|OMA\|OrthoInspector\|PANTHER)
Caenorhabditis elegans (roundworm):	unc-64	Alliance	DIOPT (Hieranoid\|InParanoid\|OrthoFinder\|PANTHER\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	stx2	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	stx2	Alliance	DIOPT (OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Allele / Splice:

Stx2_v1 ; Stx2_v4 ; Stx2_v3 ; Stx2_v2

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	12	33,315,447 - 33,350,788 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	12	33,315,750 - 33,350,788 (+)	Ensembl				GRCr8
mRatBN7.2	12	27,678,744 - 27,714,751 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	12	27,689,819 - 27,714,751 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	12	28,829,065 - 28,850,843 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	12	29,439,629 - 29,461,407 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	12	28,498,608 - 28,520,373 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	12	31,324,203 - 31,360,249 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	12	31,335,372 - 31,360,254 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	12	33,250,624 - 33,286,683 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	12	28,751,591 - 28,773,351 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	12	29,385,007 - 29,406,766 (+)	NCBI		Celera
RGSC_v3.1	12	28,614,978 - 28,636,739 (+)	NCBI
RH 3.4 Map	12	461.4	RGD
Cytogenetic Map	12	q13	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

male infertility (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(+)-schisandrin B (EXP)

17alpha-ethynylestradiol (ISO)

17beta-estradiol (ISO)

17beta-hydroxy-5alpha-androstan-3-one (ISO)

2,3',4,4',5-Pentachlorobiphenyl (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2-ethoxyethanol (EXP)

2-methoxyethanol (EXP)

3-chloropropane-1,2-diol (EXP)

4,4'-sulfonyldiphenol (ISO)

4-hydroxyphenyl retinamide (ISO)

8-Br-cAMP (ISO)

aflatoxin B1 (ISO)

all-trans-retinoic acid (ISO)

ammonium chloride (EXP)

aristolochic acid A (ISO)

arsane (ISO)

arsenic atom (ISO)

benzo[a]pyrene (ISO)

bisphenol A (EXP,ISO)

cadmium atom (ISO)

carboplatin (ISO)

chlorpyrifos (ISO)

ciguatoxin CTX1B (ISO)

copper(II) sulfate (ISO)

Cuprizon (EXP)

cycloheximide (ISO)

diethylstilbestrol (ISO)

doxorubicin (ISO)

endosulfan (EXP)

fipronil (EXP)

flavonoids (EXP)

gentamycin (EXP)

ketoconazole (ISO)

manganese atom (ISO)

manganese(0) (ISO)

manganese(II) chloride (ISO)

methylmercury chloride (ISO)

methylseleninic acid (ISO)

monosodium L-glutamate (ISO)

N-ethyl-N-nitrosourea (ISO)

N-nitrosodiethylamine (EXP)

oxaliplatin (EXP)

paracetamol (ISO)

phenethyl caffeate (EXP)

pirinixic acid (ISO)

pregnenolone 16alpha-carbonitrile (ISO)

resveratrol (ISO)

sodium arsenite (EXP,ISO)

temozolomide (ISO)

tetrachloromethane (EXP,ISO)

thimerosal (ISO)

thioacetamide (EXP)

topotecan (EXP)

trichostatin A (EXP)

triptonide (ISO)

valproic acid (ISO)

vinclozolin (EXP)

vorinostat (ISO)

zinc atom (EXP)

zinc(0) (EXP)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

acrosome reaction (ISO)

cell differentiation (ISO)

cellular response to oxidative stress (IEA,ISO)

cornified envelope assembly (IEA,ISO)

digestive tract morphogenesis (IMP)

epithelial cell differentiation (IMP)

exocytosis (IBA)

intracellular protein transport (IBA,IEA)

intracellular transport (TAS)

membrane fusion (IEA)

microvillus assembly (IDA)

midbody abscission (IMP)

mitotic cytokinesis (IMP)

synaptic vesicle fusion to presynaptic active zone membrane (IBA)

vesicle docking (IBA)

vesicle fusion (TAS)

vesicle targeting (TAS)

vesicle-mediated transport (IEA,TAS)

Cellular Component

basolateral plasma membrane (IEA,ISO)

cell surface (ISO)

cell-cell junction (ISO)

cytoplasmic vesicle (ISO)

endomembrane system (IBA)

extracellular space (IEA,ISO)

lamellipodium (IEA,ISO)

membrane (IEA)

membrane raft (ISO)

midbody (IDA)

plasma membrane (IBA,IEA,ISO)

presynaptic active zone membrane (IBA)

protein-containing complex (IEA,ISO)

SNARE complex (IBA)

synapse (IDA,IEP)

Molecular Function

calcium-dependent protein binding (ISO)

identical protein binding (ISO)

protein binding (IPI,ISO)

SNAP receptor activity (IBA,IEA)

SNARE binding (IBA,IMP)

structural molecule activity (IEA,ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	The septin CDCrel-1 binds syntaxin and inhibits exocytosis.	Beites CL, etal., Nat Neurosci 1999 May;2(5):434-9.
2.	The syntaxin family of vesicular transport receptors.	Bennett MK, etal., Cell 1993 Sep 10;74(5):863-73.
3.	Epimorphin expression in intestinal myofibroblasts induces epithelial morphogenesis.	Fritsch C, etal., J Clin Invest 2002 Dec;110(11):1629-41.
4.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
6.	High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence.	Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
7.	A cytosolic splice variant of Cab45 interacts with Munc18b and impacts on amylase secretion by pancreatic acini.	Lam PP, etal., Mol Biol Cell. 2007 Jul;18(7):2473-80. Epub 2007 Apr 18.
8.	Intracellular accumulation of pIgA-R and regulators of transcytotic trafficking in cholestatic rat hepatocytes.	Larkin JM, etal., Hepatology 2003 Nov;38(5):1199-209.
9.	Syntaxin 2 and endobrevin are required for the terminal step of cytokinesis in mammalian cells.	Low SH, etal., Dev Cell 2003 May;4(5):753-9.
10.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
11.	Epimorphin is involved in differentiation of rat hepatic stem-like cells through cell-cell contact.	Miura K, etal., Biochem Biophys Res Commun 2003 Nov 14;311(2):415-23.
12.	Electronic Transfer of LocusLink and RefSeq Data	NCBI rat LocusLink and RefSeq merged data July 26, 2002
13.	Syntaxin 2 splice variants exhibit differential expression patterns, biochemical properties and subcellular localizations.	Quinones B, etal., J Cell Sci 1999 Dec;112 ( Pt 23):4291-304.
14.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
15.	Molecular anatomy of a trafficking organelle.	Takamori S, etal., Cell. 2006 Nov 17;127(4):831-46.
16.	Tentative Sequence Identification Numbers	Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
17.	Functional and biochemical analysis of the C2 domains of synaptotagmin IV.	Thomas DM, etal., Mol Biol Cell. 1999 Jul;10(7):2285-95.
18.	The epimorphin gene is highly conserved among humans, mice, and rats and maps to human chromosome 7, mouse chromosome 5, and rat chromosome 12.	Zha H, etal., Genomics 1996 Nov 1;37(3):386-9.

Additional References at PubMed

PMID:7768895	PMID:8996080	PMID:11702001	PMID:11784086	PMID:15685636	PMID:15774481	PMID:16339081	PMID:16891298	PMID:17935821	PMID:18321981	PMID:20305811	PMID:21720706
PMID:21810271	PMID:21935930	PMID:22226963	PMID:23376485	PMID:24971829	PMID:25119302	PMID:28560580	PMID:31962145

Genomics

Comparative Map Data

Stx2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	12	33,315,447 - 33,350,788 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	12	33,315,750 - 33,350,788 (+)	Ensembl				GRCr8
mRatBN7.2	12	27,678,744 - 27,714,751 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	12	27,689,819 - 27,714,751 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	12	28,829,065 - 28,850,843 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	12	29,439,629 - 29,461,407 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	12	28,498,608 - 28,520,373 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	12	31,324,203 - 31,360,249 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	12	31,335,372 - 31,360,254 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	12	33,250,624 - 33,286,683 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	12	28,751,591 - 28,773,351 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	12	29,385,007 - 29,406,766 (+)	NCBI		Celera
RGSC_v3.1	12	28,614,978 - 28,636,739 (+)	NCBI
RH 3.4 Map	12	461.4	RGD
Cytogenetic Map	12	q13	NCBI

STX2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	12	130,789,600 - 130,839,250 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	12	130,789,600 - 130,839,265 (-)	Ensembl			hg38	GRCh38
GRCh37	12	131,274,145 - 131,323,795 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	12	129,840,098 - 129,889,764 (-)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	12	129,799,028 - 129,848,691	NCBI
Celera	12	130,887,358 - 130,937,200 (-)	NCBI		Celera
Cytogenetic Map	12	q24.33	NCBI
HuRef	12	128,256,936 - 128,306,689 (-)	NCBI		HuRef
CHM1_1	12	131,094,820 - 131,144,677 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	12	130,828,749 - 130,878,417 (-)	NCBI		T2T-CHM13v2.0

Stx2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	5	129,061,621 - 129,085,664 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	5	129,061,621 - 129,085,638 (-)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	5	128,984,557 - 129,008,600 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	5	128,984,557 - 129,008,574 (-)	Ensembl			mm10	GRCm38
MGSCv37	5	129,490,436 - 129,514,439 (-)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	5	129,299,275 - 129,323,282 (-)	NCBI		MGSCv36	mm8
MGSCv36	5	127,256,039 - 127,280,159 (-)	NCBI		MGSCv36	mm8
Celera	5	126,018,075 - 126,042,529 (-)	NCBI		Celera
Cytogenetic Map	5	G1.3	NCBI
cM Map	5	67.99	NCBI

Stx2
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955482	1,252,600 - 1,270,913 (+)	Ensembl
ChiLan1.0	NW_004955482	1,249,972 - 1,273,250 (+)	NCBI	ChiLan1.0	ChiLan1.0

STX2
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	10	138,861,215 - 138,910,708 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	12	138,857,716 - 138,907,215 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	12	128,416,793 - 128,464,452 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	12	132,612,870 - 132,650,554 (-)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	12	132,614,793 - 132,650,559 (-)	Ensembl			panPan2	panpan1.1

STX2
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	26	1,459,110 - 1,494,801 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	26	1,454,189 - 1,494,823 (+)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	26	1,649,625 - 1,694,969 (+)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	26	1,695,058 - 1,740,740 (+)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	26	1,695,026 - 1,726,222 (+)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	26	1,631,450 - 1,676,459 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	26	1,728,343 - 1,773,741 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	26	1,635,560 - 1,681,133 (+)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Stx2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405118	123,068,259 - 123,104,309 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936660	1,616,771 - 1,649,207 (-)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936660	1,616,774 - 1,652,585 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

STX2
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	14	24,341,549 - 24,380,626 (+)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	14	24,341,473 - 24,380,536 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	14	25,870,829 - 25,927,683 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

STX2
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	11	126,174,446 - 126,225,342 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	11	126,178,803 - 126,224,277 (-)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666037	118,795,646 - 118,846,782 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Stx2
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624747	27,249,608 - 27,272,728 (-)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624747	27,247,947 - 27,272,698 (-)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Stx2
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	16	24,965,683 - 24,988,392 (+)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Stx2
381 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	295
Count of miRNA genes:	187
Interacting mature miRNAs:	213
Transcripts:	ENSRNOT00000001242, ENSRNOT00000037296, ENSRNOT00000037306
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
631560	Apr1	Acute phase response QTL 1	6.1		orosomucoid 1 amount (VT:0010541)	plasma orosomucoid 1 level (CMO:0001467)	12	24805022	52308831	Rat
70213	Niddm27	Non-insulin dependent diabetes mellitus QTL 27	3.72		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	12	11200494	52308831	Rat
8552964	Pigfal17	Plasma insulin-like growth factor 1 level QTL 17	3.5		blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	12	11200494	52308831	Rat
8693635	Alc28	Alcohol consumption QTL 28	2.7	0.439	drinking behavior trait (VT:0001422)	calculated ethanol drink intake rate (CMO:0001615)	12	28717718	50386405	Rat
7411641	Foco19	Food consumption QTL 19	27.7	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	12	11200494	52308831	Rat
7411643	Foco20	Food consumption QTL 20		0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	12	25989355	52308831	Rat
5684888	Pia42	Pristane induced arthritis QTL 42			joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	12	3489416	48489416	Rat
1331739	Hrtrt14	Heart rate QTL 14	3.56232		heart pumping trait (VT:2000009)	heart rate (CMO:0000002)	12	1	38687564	Rat
1641928	Alcrsp5	Alcohol response QTL 5			response to alcohol trait (VT:0010489)	duration of loss of righting reflex (CMO:0002289)	12	18473041	52308831	Rat
8552912	Pigfal6	Plasma insulin-like growth factor 1 level QTL 6	5		blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	12	11200497	52308831	Rat
1549829	Scl48	Serum cholesterol level QTL 48	5		blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	12	15264248	52308831	Rat
61331	Eau2	Experimental allergic uveoretinitis QTL 2		0.0005	uvea integrity trait (VT:0010551)	experimental autoimmune uveitis score (CMO:0001504)	12	1	33700600	Rat
10059594	Kidm46	Kidney mass QTL 46	3.79	0.025	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	12	11743528	52308831	Rat
8552918	Pigfal7	Plasma insulin-like growth factor 1 level QTL 7			blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	12	11200494	52308831	Rat
2293684	Bmd26	Bone mineral density QTL 26	4.4	0.0002	femur mineral mass (VT:0010011)	total volumetric bone mineral density (CMO:0001728)	12	1	38635130	Rat
70169	Eae13	Experimental allergic encephalomyelitis QTL 13		0.032	nervous system integrity trait (VT:0010566)	experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)	12	29775522	42298555	Rat
61404	Bw120	Body weight QTL 120	5.1		body mass (VT:0001259)	body mass index (BMI) (CMO:0000105)	12	17464979	46784661	Rat
1331786	Kidm11	Kidney mass QTL 11	3.571		kidney mass (VT:0002707)	right kidney wet weight (CMO:0000082)	12	16187438	52308831	Rat
8693658	Alc33	Alcohol consumption QTL 33	2.1	0.68	drinking behavior trait (VT:0001422)	calculated ethanol drink intake rate (CMO:0001615)	12	28717718	49212240	Rat
1331787	Rf41	Renal function QTL 41	2.998		kidney blood vessel physiology trait (VT:0100012)	absolute change in renal blood flow rate (CMO:0001168)	12	1	33700556	Rat
2293699	Bss49	Bone structure and strength QTL 49	5.61	0.0001	lumbar vertebra size trait (VT:0010518)	lumbar vertebra trabecular cross-sectional area (CMO:0001692)	12	16135029	52308831	Rat
1331761	Bp218	Blood pressure QTL 218	2.973		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	12	16187438	51213550	Rat
1331763	Wbc2	White blood cell count QTL 2	3.162		leukocyte quantity (VT:0000217)	total white blood cell count (CMO:0000365)	12	11200494	52308831	Rat
61416	Pia4	Pristane induced arthritis QTL 4	8.4		joint integrity trait (VT:0010548)	arthritic paw count (CMO:0001460)	12	18749469	36488809	Rat
7411547	Bw129	Body weight QTL 129		0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	6	11200494	52308831	Rat
7387292	Kidm42	Kidney mass QTL 42	3.03	0.0004	kidney mass (VT:0002707)	left kidney wet weight (CMO:0000083)	12	1	41361854	Rat
61421	Cia12	Collagen induced arthritis QTL 12	4.6		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	12	18749469	34312613	Rat
1300157	Rf21	Renal function QTL 21	4.4		renal blood flow trait (VT:2000006)	absolute change in renal blood flow rate (CMO:0001168)	12	29636637	37764351	Rat
1298081	Cia25	Collagen induced arthritis QTL 25	4.7		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	12	2747694	47747694	Rat
2303569	Gluco44	Glucose level QTL 44	2		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	12	18473041	52308831	Rat
2303575	Insul14	Insulin level QTL 14	4		blood insulin amount (VT:0001560)	blood insulin level (CMO:0000349)	12	3087180	48087180	Rat
7411588	Foco6	Food consumption QTL 6		0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	12	11200494	52308831	Rat
7243862	Mcs30	Mammary carcinoma susceptibility QTL 30	8.62		mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	12	5633306	50633306	Rat
2300186	Bmd59	Bone mineral density QTL 59	7.1	0.0001	lumbar vertebra mineral mass (VT:0010511)	volumetric bone mineral density (CMO:0001553)	12	16135029	52308831	Rat
2293086	Iddm30	Insulin dependent diabetes mellitus QTL 30	3.82		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	12	7901625	33938215	Rat
7411597	Foco10	Food consumption QTL 10		0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	12	11200494	52308831	Rat
1331755	Bp219	Blood pressure QTL 219	3.041		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	12	16187438	33700556	Rat

Markers in Region

RH94687

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	12	27,699,166 - 27,699,285 (+)	MAPPER	mRatBN7.2
Rnor_6.0	12	31,344,669 - 31,344,787	NCBI	Rnor6.0
Rnor_5.0	12	33,271,103 - 33,271,221	UniSTS	Rnor5.0
RGSC_v3.4	12	28,760,835 - 28,760,953	UniSTS	RGSC3.4
Celera	12	29,394,250 - 29,394,368	UniSTS
RH 3.4 Map	12	461.4	UniSTS
Cytogenetic Map	12	q16	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
16	12	67	164	91	90	59	92	59	6	356	192	11	143	81	92	31	17	17

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001415751	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_012748	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006249253	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008769188	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017598270	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017598271	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039089101	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039089103	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063271077	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC118310	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AC136867	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AH006759	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AY302700	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473973	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000012	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	L20823	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	L20888	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	L20889	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000001242 ⟹ ENSRNOP00000001242

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	12	33,325,852 - 33,350,778 (+)	Ensembl
mRatBN7.2 Ensembl	12	27,689,827 - 27,714,751 (+)	Ensembl
Rnor_6.0 Ensembl	12	31,335,372 - 31,360,254 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000037296 ⟹ ENSRNOP00000036115

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	12	33,315,750 - 33,345,327 (+)	Ensembl
mRatBN7.2 Ensembl	12	27,699,149 - 27,709,290 (+)	Ensembl
Rnor_6.0 Ensembl	12	31,335,425 - 31,355,445 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000094953 ⟹ ENSRNOP00000091323

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	12	33,335,186 - 33,350,788 (+)	Ensembl
mRatBN7.2 Ensembl	12	27,699,149 - 27,714,751 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000099417 ⟹ ENSRNOP00000085955

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	12	33,315,750 - 33,350,778 (+)	Ensembl
mRatBN7.2 Ensembl	12	27,689,842 - 27,714,739 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000099729 ⟹ ENSRNOP00000092669

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	12	33,325,852 - 33,345,980 (+)	Ensembl
mRatBN7.2 Ensembl	12	27,689,819 - 27,709,943 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000138236 ⟹ ENSRNOP00000100146

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	12	33,340,209 - 33,350,788 (+)	Ensembl

RefSeq Acc Id:

NM_001415751 ⟹ NP_001402680

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	12	33,325,869 - 33,350,788 (+)	NCBI
mRatBN7.2	12	27,689,830 - 27,714,751 (+)	NCBI

RefSeq Acc Id:

NM_012748 ⟹ NP_036880

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	12	33,325,869 - 33,350,788 (+)	NCBI
mRatBN7.2	12	27,689,830 - 27,714,751 (+)	NCBI
Rnor_6.0	12	31,335,425 - 31,357,185 (+)	NCBI
Rnor_5.0	12	33,250,624 - 33,286,683 (+)	NCBI
RGSC_v3.4	12	28,751,591 - 28,773,351 (+)	RGD
Celera	12	29,385,007 - 29,406,766 (+)	RGD

Sequence:

show sequence

ATGCGGGACCGGCTGCCGGACCTCACGGCGTGTAGGAAAAGCGACGATGGAGACAATGCTGTCA
TCATCACGGTGGAGAAGGACCACTTCATGGATGCCTTCTTCCATCAGGTGGAGGAGATTCGAAG
CAGCATAGCCAGGATTGCTCAGCACGTGGAGGATGTGAAGAAGAACCACAGCATCATCCTCTCT
GCCCCAAACCCAGAAGGAAAAATAAAAGAAGAGCTGGAGGACCTGAACAAAGAGATCAAGAAAA
CTGCTAACAGGATCCGGGGCAAGCTGAAGGCTATTGAGCAGAGTTGTGATCAGGACGAGAATGG
GAACCGAACTTCAGTGGATCTGCGGATACGAAGGACCCAGCACTCAGTGCTGTCACGGAAGTTT
GTGGACGTCATGACAGAATACAATGAAGCACAGATCCTGTTTCGGGAGCGAAGCAAAGGCCGAA
TCCAGCGCCAGCTAGAGATCACTGGGAGGACCACCACTGACGAGGAGCTGGAGGAGATGCTGGA
GAGCGGGAAGCCGTCCATCTTCATCTCGGACATTATATCAGATTCACAGATTACTAGGCAAGCT
CTCAATGAGATCGAGTCACGCCACAAAGACATCATGAAGCTGGAGACCAGCATCCGAGAGCTGC
ACGAGATGTTCATGGATATGGCCATGTTTGTCGAGACTCAGGGTGAAATGGTCAACAACATTGA
GAGAAACGTGGTGAACTCCGTAGATTACGTGGAGCACGCCAAGGAAGAGACTAAGAAAGCCATC
AAATACCAGAGCAAGGCCAGACGGAAAAAGTGGATAATTGCTGCTGTGGTGGTGGCTGTCATTG
CTGTCCTGGCTCTAATCATTGGCTTGACGGTTGGCAAATGATTGCGTAGATGGCGCTGGGTGCT
TGCCTCTCCCTCAGG

hide sequence

RefSeq Acc Id:

XM_006249253 ⟹ XP_006249315

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	12	33,315,447 - 33,346,760 (+)	NCBI
mRatBN7.2	12	27,678,744 - 27,713,274 (+)	NCBI
Rnor_6.0	12	31,324,203 - 31,358,725 (+)	NCBI
Rnor_5.0	12	33,250,624 - 33,286,683 (+)	NCBI

Sequence:

show sequence

GAGGGCGCGCGGCTGCTGTCTGCAGAATGAATGGGGTGAATGAATGAGGGTGCGCGTGCCCGAG
GCCCGGCTTGCGTCAGCCATGCGTACTAGGCATGGACACGGCCTGGGATTCATGCGTGGGGTTT
TGTGGTCCTAGCTGTGGACGGGACCGGATGCAGTTAGTCCAAGCGTTCTGCACCCCGGAGCCCT
TCCTCTGTTGCATAGTCCGAGTAATCCATTTCTCAGAAAAGACCCCACCCAGGCTCCCTCCGGA
GCAGCAATGGACCAGGGAGGGATCCTCACAGGCCTGGAGAAATAACAGATTAGGCCTGCTGAGA
GCCAAGTTCCACTCCCCAAAGCACTAGCAAATACAGATGCTGCTAGGAAAATAGAAAATGTATC
TCTGATGACCAGAGCTTGGGGCCCTGCTGTTACTTTGTACTATGCAATCTAAAAGGAGCCGAGG
TGTGGAAGATGGGAAAATGGTTGTGTGTGCTACAAAGACTATTACGTAACGTTAACATAGTATT
GTGTGATGGAATGCCAGTTACATGTTTATATAAATACAAAATTACTATATTGTTGGGTGTGTGT
AACAAGTCAGTTCCAAGGGGCTATACTGTGAACCGTGTTCAATAGAGGTTAGAAAGGGTGGTGA
TCACTTTAGGAGAAAACTGTTAACCCACCTAGTTCCAGTTCGGTAGGTTGCTGGGTGATGAGAG
CACCAGCGACCCTCTCCCCTGGAGAACTTACCACAAAGTTACTGTCCGGGCATCTAGCCTGCAG
AACGGCATCATCAGGTGGCTTGGTTTATGTTACTAACTAGCTGACCCAAACTTAGAATTTACAA
AGACCCTCATTCTAGGAGGCAGAGAGAAACAAGAAACTACACTCAAGCCGGCGTAGGCGCCGCT
TTTCTGCCATCATCGCCCAGTCTCCAGGTTTACAGCTGCTGGCTGGTTTACAGCGTTGTGTTTG
CCATCCAATGTGAACTGCAAACCTATTCTTAGCCTGAACTTTAAAACTTGGCAGCTGCTTAGCA
TGTATGAGAACTGGGGCGGGGGTGGGGGTCGGGAGGCAGCTATAGACAGGTTAATTTGTACAGC
CTAGGGGAAAAGTTGCGGTTGTGGAAGGGATTGTAGCTTGTGAGAGTTAGTCTATAGGGTTTAG
GGTTGCCTAGCACACAAACCTCTGGGTGTGTCTCTTGTACTCACGGAGAGGTTTAACTGAACCT
GGGCTGTATGCTAGACTGAATAGGAAGGAGAAAGGGAACTGAACACCAGCCTCCATCTCTCTGC
TTCCTGGCACCTCACGCTCCTGCTGCCGTGCCTTCTACCTTCCACAGATATAATAGATTGTACC
ACTGAAACTGTGAGCCAAAACTAAACTAACTAAAAATTGCTTTTTATCAAGTATTTTTGTCATA
GCAATGTGCAAAATAGCTAATTACATTTTCTTCTAAATCCCCAAATCTCTTGTTTAATTTGTAT
TTGAGATAACCCCTGTCAGCTCCTGTGATGGACATCTCGTTCTCCACCAATGGTGCTGTTTTAG
ACTTGCGACCTAGTGTGTGTCTGGGGGCGAGGGGTCAACCTTGAAGCATATATCCTGTAGTATT
TAGTCACAGTGCGAAGCTTCGAGCTCCCACCACCATGGAGTGAGACCCAACGCCATGCCATCCT
GCCGTGATGGACTGTATCCCCCGTGAACCAAGGTGCCTGCCGTGATTTGTTGCCTGCTCACAGG
CCCAAAGCAGTGAACCAGCCAACCGACCACAGGCTGAATCCTTGAAACCCTGTAGGAAAAGCGA
CGATGGAGACAATGCTGTCATCATCACGGTGGAGAAGGACCACTTCATGGATGCCTTCTTCCAT
CAGGTGGAGGAGATTCGAAGCAGCATAGCCAGGATTGCTCAGCACGTGGAGGATGTGAAGAAGA
ACCACAGCATCATCCTCTCTGCCCCAAACCCAGAAGGAAAAATAAAAGAAGAGCTGGAGGACCT
GAACAAAGAGATCAAGAAAACTGCTAACAGGATCCGGGGCAAGCTGAAGGCTATTGAGCAGAGT
TGTGATCAGGACGAGAATGGGAACCGAACTTCAGTGGATCTGCGGATACGAAGGACCCAGCACT
CAGTGCTGTCACGGAAGTTTGTGGACGTCATGACAGAATACAATGAAGCACAGATCCTGTTTCG
GGAGCGAAGCAAAGGCCGAATCCAGCGCCAGCTAGAGATCACTGGGAGGACCACCACTGACGAG
GAGCTGGAGGAGATGCTGGAGAGCGGGAAGCCGTCCATCTTCATCTCGGACATTATATCAGATT
CACAGATTACTAGGCAAGCTCTCAATGAGATCGAGTCACGCCACAAAGACATCATGAAGCTGGA
GACCAGCATCCGAGAGCTGCACGAGATGTTCATGGATATGGCCATGTTTGTCGAGACTCAGGGT
GAAATGGTCAACAACATTGAGAGAAACGTGGTGAACTCCGTAGATTACGTGGAGCACGCCAAGG
AAGAGACTAAGAAAGCCATCAAATACCAGAGCAAGGCCAGACGGAAAAAGTGGATAATTGCTGC
TGTGGTGGTGGCTGTCATTGCTGTCCTGGCTCTAATCATTGGCTTGTCGGTTGGCAAATGATTG
CGTAGATGGCGCTGGGTGCTTGCCTCTCCCTCAGGGTGGCAAAGGTGATGTTCGTCCTCATCTG
TGTAGTCACTTTGCTTGTGATCCTTGGAATTATTCTAGCAACAGCATTGTCATAGCAACCGCAC

hide sequence

RefSeq Acc Id:

XM_017598270 ⟹ XP_017453759

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	12	33,315,447 - 33,346,760 (+)	NCBI
mRatBN7.2	12	27,678,744 - 27,713,274 (+)	NCBI
Rnor_6.0	12	31,324,203 - 31,358,725 (+)	NCBI

Sequence:

show sequence

GAGGGCGCGCGGCTGCTGTCTGCAGAATGAATGGGGTGAATGAATGAGGGTGCGCGTGCCCGAG
GCCCGGCTTGCGTCAGCCATGCGTACTAGGCATGGACACGGCCTGGGATTCATGCGTGGGGTTT
TGTGGTCCTAGCTGTGGACGGGACCGGATGCAGTTAGTCCAAGCGTTCTGCACCCCGGAGCCCT
TCCTCTGTTGCATAGTCCGAGTAATCCATTTCTCAGAAAAGACCCCACCCAGGCTCCCTCCGGA
GCAGCAATGGACCAGGGAGGGATCCTCACAGGCCTGGAGAAATAACAGATTAGGCCTGCTGAGA
GCCAAGTTCCACTCCCCAAAGCACTAGCAAATACAGATGCTGCTAGGAAAATAGAAAATGTATC
TCTGATGACCAGAGCTTGGGGCCCTGCTGTTACTTTGTACTATGCAATCTAAAAGGAGCCGAGG
TGTGGAAGATGGGAAAATGGTTGTGTGTGCTACAAAGACTATTACGTAACGTTAACATAGTATT
GTGTGATGGAATGCCAGTTACATGTTTATATAAATACAAAATTACTATATTGTTGGGTGTGTGT
AACAAGTCAGTTCCAAGGGGCTATACTGTGAACCGTGTTCAATAGAGGTTAGAAAGGGTGGTGA
TCACTTTAGGAGAAAACTGTTAACCCACCTAGTTCCAGTTCGGTAGGTTGCTGGGTGATGAGAG
CACCAGCGACCCTCTCCCCTGGAGAACTTACCACAAAGTTACTGTCCGGGCATCTAGCCTGCAG
AACGGCATCATCAGGTGGCTTGGTTTATGTTACTAACTAGCTGACCCAAACTTAGAATTTACAA
AGACCCTCATTCTAGGAGGCAGAGAGAAACAAGAAACTACACTCAAGCCGGCGTAGGCGCCGCT
TTTCTGCCATCATCGCCCAGTCTCCAGGTTTACAGCTGCTGGCTGGTTTACAGCGTTGTGTTTG
CCATCCAATGTGAACTGCAAACCTATTCTTAGCCTGAACTTTAAAACTTGGCAGCTGCTTAGCA
TGTATGAGAACTGGGGCGGGGGTGGGGGTCGGGAGGCAGCTATAGACAGGTTAATTTGTACAGC
CTAGGGGAAAAGTTGCGGTTGTGGAAGGGATTGTAGCTTGTGAGAGTTAGTCTATAGGGTTTAG
GGTTGCCTAGCACACAAACCTCTGGGTGTGTCTCTTGTACTCACGGAGAGGTTTAACTGAACCT
GGGCTGTATGCTAGACTGAATAGGAAGGAGAAAGGGAACTGAACACCAGCCTCCATCTCTCTGC
TTCCTGGCACCTCACGCTCCTGCTGCCGTGCCTTCTACCTTCCACAGATATAATAGATTGTACC
ACTGAAACTGTGAGCCAAAACTAAACTAACTAAAAATTGCTTTTTATCAAGTATTTTTGTCATA
GCAATGTGCAAAATAGCTAATTACATTTTCTTCTAAATCCCCAAATCTCTTGTTTAATTTGTAT
TTGAGATAACCCCTGTCAGCTCCTGTGATGGACATCTCGTTCTCCACCAATGGTGCTGTTTTAG
ACTTGCGACCTAGTGTGTGTCTGGGGGCGAGGGGTCAACCTTGAAGCATATATCCTGTAGTATT
TAGTCACAGTGCGAAGCTTCGAGCTCCCACCACCATGGAGTGAGACCCAACGCCATGCCATCCT
GCCGTGATGGACTGTATCCCCCGTGAACCAAGTACTCAGCCGACATCAAACTCAGCATCTTTGG
CTTCCACCATGAACCACTGGGATTCCTAAGGCATTCAGCCATATGGACTGACCAACTCCGGAGT
TCTCAGGCTCTCCAGCATGTGCCTGCCGTGATTTGTTGCCTGCTCACAGGCCCAAAGCAGTGAA
CCAGCCAACCGACCACAGGCTGAATCCTTGAAACCCTGTAGGAAAAGCGACGATGGAGACAATG
CTGTCATCATCACGGTGGAGAAGGACCACTTCATGGATGCCTTCTTCCATCAGGTGGAGGAGAT
TCGAAGCAGCATAGCCAGGATTGCTCAGCACGTGGAGGATGTGAAGAAGAACCACAGCATCATC
CTCTCTGCCCCAAACCCAGAAGGAAAAATAAAAGAAGAGCTGGAGGACCTGAACAAAGAGATCA
AGAAAACTGCTAACAGGATCCGGGGCAAGCTGAAGGCTATTGAGCAGAGTTGTGATCAGGACGA
GAATGGGAACCGAACTTCAGTGGATCTGCGGATACGAAGGACCCAGCACTCAGTGCTGTCACGG
AAGTTTGTGGACGTCATGACAGAATACAATGAAGCACAGATCCTGTTTCGGGAGCGAAGCAAAG
GCCGAATCCAGCGCCAGCTAGAGATCACTGGGAGGACCACCACTGACGAGGAGCTGGAGGAGAT
GCTGGAGAGCGGGAAGCCGTCCATCTTCATCTCGGACATTATATCAGATTCACAGATTACTAGG
CAAGCTCTCAATGAGATCGAGTCACGCCACAAAGACATCATGAAGCTGGAGACCAGCATCCGAG
AGCTGCACGAGATGTTCATGGATATGGCCATGTTTGTCGAGACTCAGGGTGAAATGGTCAACAA
CATTGAGAGAAACGTGGTGAACTCCGTAGATTACGTGGAGCACGCCAAGGAAGAGACTAAGAAA
GCCATCAAATACCAGAGCAAGGCCAGACGGAAAAAGTGGATAATTGCTGCTGTGGTGGTGGCTG
TCATTGCTGTCCTGGCTCTAATCATTGGCTTGTCGGTTGGCAAATGATTGCGTAGATGGCGCTG
GGTGCTTGCCTCTCCCTCAGGGTGGCAAAGGTGATGTTCGTCCTCATCTGTGTAGTCACTTTGC
TTGTGATCCTTGGAATTATTCTAGCAACAGCATTGTCATAGCAACCGCAC

hide sequence

RefSeq Acc Id:

XM_017598271 ⟹ XP_017453760

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	12	33,325,795 - 33,346,552 (+)	NCBI
mRatBN7.2	12	27,689,755 - 27,710,515 (+)	NCBI
Rnor_6.0	12	31,335,266 - 31,356,017 (+)	NCBI

Sequence:

show sequence

CGCAGAGAGTGCGGGCGCGGTTGCCGTGGCAGCGCCTGCCCGAGGGAGGGCGGCGGCGCGGGGC
CAGGACCCCGGCGGGCAGAGGCGGCGACGCGGCCACCCGAGAGTGTGCGGCGGGGCAGCTGAGC
GGCGGGAGCTCCGCCCTGCTGGCTGGTGGGGATGCGGGACCGGCTGCCGGACCTCACGGCGTGT
AGGAAAAGCGACGATGGAGACAATGCTGTCATCATCACGGTGGAGAAGGACCACTTCATGGATG
CCTTCTTCCATCAGGTGGAGGAGATTCGAAGCAGCATAGCCAGGATTGCTCAGCACGTGGAGGA
TGTGAAGAAGAACCACAGCATCATCCTCTCTGCCCCAAACCCAGAAGGAAAAATAAAAGAAGAG
CTGGAGGACCTGAACAAAGAGATCAAGAAAACTGCTAACAGGATCCGGGGCAAGCTGAAGGCTA
TTGAGCAGAGTTGTGATCAGGACGAGAATGGGAACCGAACTTCAGTGGATCTGCGGATACGAAG
GACCCAGCACTCAGTGCTGTCACGGAAGTTTGTGGACGTCATGACAGAATACAATGAAGCACAG
ATCCTGTTTCGGGAGCGAAGCAAAGGCCGAATCCAGCGCCAGCTAGAGATCACTGGGAGGACCA
CCACTGACGAGGAGCTGGAGGAGATGCTGGAGAGCGGGAAGCCGTCCATCTTCATCTCGGACAT
TATATCAGATTCACAGATTACTAGGCAAGCTCTCAATGAGATCGAGTCACGCCACAAAGACATC
ATGAAGCTGGAGACCAGCATCCGAGAGCTGCACGAGATGTTCATGGATATGGCCATGTTTGTCG
AGACTCAGACTCTGTCTCCTCCCGGACGGGACCCAGGGTGAAATGGTCAACAACATTGAGAGAA
ACGTGGTGAACTCCGTAGATTACGTGGAGCACGCCAAGGAAGAGACTAAGAAAGCCATCAAATA
CCAGAGCAAGGCCAGACGG

hide sequence

RefSeq Acc Id:

XM_039089101 ⟹ XP_038945029

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	12	33,325,796 - 33,350,788 (+)	NCBI
mRatBN7.2	12	27,689,755 - 27,714,751 (+)	NCBI

RefSeq Acc Id:

XM_039089103 ⟹ XP_038945031

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	12	33,344,345 - 33,349,198 (+)	NCBI
mRatBN7.2	12	27,708,313 - 27,713,274 (+)	NCBI

RefSeq Acc Id:

XM_063271077 ⟹ XP_063127147

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	12	33,325,795 - 33,346,760 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_001402680	(Get FASTA)	NCBI Sequence Viewer
	NP_036880	(Get FASTA)	NCBI Sequence Viewer
	XP_006249315	(Get FASTA)	NCBI Sequence Viewer
	XP_017453759	(Get FASTA)	NCBI Sequence Viewer
	XP_017453760	(Get FASTA)	NCBI Sequence Viewer
	XP_038945029	(Get FASTA)	NCBI Sequence Viewer
	XP_038945031	(Get FASTA)	NCBI Sequence Viewer
	XP_063127147	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAA03044	(Get FASTA)	NCBI Sequence Viewer
	AAA03048	(Get FASTA)	NCBI Sequence Viewer
	AAA03049	(Get FASTA)	NCBI Sequence Viewer
	AAC52908	(Get FASTA)	NCBI Sequence Viewer
	AAP69908	(Get FASTA)	NCBI Sequence Viewer
	EDM13514	(Get FASTA)	NCBI Sequence Viewer
	EDM13515	(Get FASTA)	NCBI Sequence Viewer
	EDM13516	(Get FASTA)	NCBI Sequence Viewer
	EDM13517	(Get FASTA)	NCBI Sequence Viewer
	EDM13518	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000001242
	ENSRNOP00000085955
	ENSRNOP00000085955.1
	ENSRNOP00000092669
GenBank Protein	P50279	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:	NP_036880 ⟸ NM_012748
- Peptide Label:	isoform 1
- UniProtKB:	Q08848 (UniProtKB/Swiss-Prot), Q08847 (UniProtKB/Swiss-Prot), Q08846 (UniProtKB/Swiss-Prot), P50279 (UniProtKB/Swiss-Prot), G3V632 (UniProtKB/TrEMBL), A6J0S7 (UniProtKB/TrEMBL)
- Sequence:	show sequence MRDRLPDLTACRKSDDGDNAVIITVEKDHFMDAFFHQVEEIRSSIARIAQHVEDVKKNHSIILS APNPEGKIKEELEDLNKEIKKTANRIRGKLKAIEQSCDQDENGNRTSVDLRIRRTQHSVLSRKF VDVMTEYNEAQILFRERSKGRIQRQLEITGRTTTDEELEEMLESGKPSIFISDIISDSQITRQA LNEIESRHKDIMKLETSIRELHEMFMDMAMFVETQGEMVNNIERNVVNSVDYVEHAKEETKKAI KYQSKARRKKWIIAAVVVAVIAVLALIIGLTVGK hide sequence

RefSeq Acc Id:	XP_006249315 ⟸ XM_006249253
- Peptide Label:	isoform X3
- UniProtKB:	A0A8I6AF84 (UniProtKB/TrEMBL)
- Sequence:	show sequence MDAFFHQVEEIRSSIARIAQHVEDVKKNHSIILSAPNPEGKIKEELEDLNKEIKKTANRIRGKL KAIEQSCDQDENGNRTSVDLRIRRTQHSVLSRKFVDVMTEYNEAQILFRERSKGRIQRQLEITG RTTTDEELEEMLESGKPSIFISDIISDSQITRQALNEIESRHKDIMKLETSIRELHEMFMDMAM FVETQGEMVNNIERNVVNSVDYVEHAKEETKKAIKYQSKARRKKWIIAAVVVAVIAVLALIIGL SVGK hide sequence

RefSeq Acc Id:	XP_017453759 ⟸ XM_017598270
- Peptide Label:	isoform X3
- UniProtKB:	A0A8I6AF84 (UniProtKB/TrEMBL)
- Sequence:	show sequence MDAFFHQVEEIRSSIARIAQHVEDVKKNHSIILSAPNPEGKIKEELEDLNKEIKKTANRIRGKL KAIEQSCDQDENGNRTSVDLRIRRTQHSVLSRKFVDVMTEYNEAQILFRERSKGRIQRQLEITG RTTTDEELEEMLESGKPSIFISDIISDSQITRQALNEIESRHKDIMKLETSIRELHEMFMDMAM FVETQGEMVNNIERNVVNSVDYVEHAKEETKKAIKYQSKARRKKWIIAAVVVAVIAVLALIIGL SVGK hide sequence

RefSeq Acc Id:	XP_017453760 ⟸ XM_017598271
- Peptide Label:	isoform X4
- UniProtKB:	Q7TS57 (UniProtKB/TrEMBL), A0A0H2UHU9 (UniProtKB/TrEMBL)
- Sequence:	show sequence MRDRLPDLTACRKSDDGDNAVIITVEKDHFMDAFFHQVEEIRSSIARIAQHVEDVKKNHSIILS APNPEGKIKEELEDLNKEIKKTANRIRGKLKAIEQSCDQDENGNRTSVDLRIRRTQHSVLSRKF VDVMTEYNEAQILFRERSKGRIQRQLEITGRTTTDEELEEMLESGKPSIFISDIISDSQITRQA LNEIESRHKDIMKLETSIRELHEMFMDMAMFVETQTLSPPGRDPG hide sequence

Ensembl Acc Id:

ENSRNOP00000036115 ⟸ ENSRNOT00000037296

Ensembl Acc Id:

ENSRNOP00000001242 ⟸ ENSRNOT00000001242

RefSeq Acc Id:	XP_038945029 ⟸ XM_039089101
- Peptide Label:	isoform X2
- UniProtKB:	Q08848 (UniProtKB/Swiss-Prot), Q08847 (UniProtKB/Swiss-Prot), Q08846 (UniProtKB/Swiss-Prot), P50279 (UniProtKB/Swiss-Prot), A6J0S5 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038945031 ⟸ XM_039089103
- Peptide Label:	isoform X5

Ensembl Acc Id:

ENSRNOP00000091323 ⟸ ENSRNOT00000094953

Ensembl Acc Id:

ENSRNOP00000092669 ⟸ ENSRNOT00000099729

Ensembl Acc Id:

ENSRNOP00000085955 ⟸ ENSRNOT00000099417

RefSeq Acc Id:	NP_001402680 ⟸ NM_001415751
- Peptide Label:	isoform 2
- UniProtKB:	Q08848 (UniProtKB/Swiss-Prot), Q08847 (UniProtKB/Swiss-Prot), Q08846 (UniProtKB/Swiss-Prot), P50279 (UniProtKB/Swiss-Prot), A6J0S6 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_063127147 ⟸ XM_063271077
- Peptide Label:	isoform X1
- UniProtKB:	Q08848 (UniProtKB/Swiss-Prot), Q08847 (UniProtKB/Swiss-Prot), Q08846 (UniProtKB/Swiss-Prot), P50279 (UniProtKB/Swiss-Prot)

Ensembl Acc Id:

ENSRNOP00000100146 ⟸ ENSRNOT00000138236

Protein Domains

t-SNARE coiled-coil homology

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-P50279-F1-model_v2	AlphaFold	P50279	1-290	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13698594

Promoter ID:

EPDNEW_R9119

Type:

initiation region

Name:

Stx2_1

Description:

syntaxin 2

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	12	31,335,346 - 31,335,406	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:2558	AgrOrtholog
BioCyc Gene	G2FUF-19468	BioCyc
Ensembl Genes	ENSRNOG00000000936	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript	ENSRNOT00000001242	ENTREZGENE
	ENSRNOT00000099417	ENTREZGENE
	ENSRNOT00000099417.1	UniProtKB/Swiss-Prot
	ENSRNOT00000099729	ENTREZGENE
Gene3D-CATH	1.20.5.110	UniProtKB/Swiss-Prot
	1.20.58.70	UniProtKB/Swiss-Prot
InterPro	SNARE	UniProtKB/Swiss-Prot
	STX2	UniProtKB/Swiss-Prot
	Syntaxin	UniProtKB/Swiss-Prot
	Syntaxin/epimorphin_CS	UniProtKB/Swiss-Prot
	Syntaxin_N	UniProtKB/Swiss-Prot
	T_SNARE_dom	UniProtKB/Swiss-Prot
KEGG Report	rno:25130	UniProtKB/Swiss-Prot
NCBI Gene	25130	ENTREZGENE
PANTHER	PTHR19957	UniProtKB/Swiss-Prot
	PTHR19957:SF36	UniProtKB/Swiss-Prot
Pfam	SNARE	UniProtKB/Swiss-Prot
	Syntaxin	UniProtKB/Swiss-Prot
PhenoGen	Stx2	PhenoGen
PROSITE	SYNTAXIN	UniProtKB/Swiss-Prot
	T_SNARE	UniProtKB/Swiss-Prot
RatGTEx	ENSRNOG00000000936	RatGTEx
SMART	SynN	UniProtKB/Swiss-Prot
	t_SNARE	UniProtKB/Swiss-Prot
Superfamily-SCOP	SSF47661	UniProtKB/Swiss-Prot
TIGR	TC232292
UniProt	A0A0H2UHU9	ENTREZGENE, UniProtKB/TrEMBL
	A0A8I6AF84	ENTREZGENE, UniProtKB/TrEMBL
	A0ABK0KYN5_RAT	UniProtKB/TrEMBL
	A6J0S5	ENTREZGENE, UniProtKB/TrEMBL
	A6J0S6	ENTREZGENE, UniProtKB/TrEMBL
	A6J0S7	ENTREZGENE, UniProtKB/TrEMBL
	A6J0S9_RAT	UniProtKB/TrEMBL
	G3V632	ENTREZGENE, UniProtKB/TrEMBL
	P50279	ENTREZGENE
	Q08846	ENTREZGENE
	Q08847	ENTREZGENE
	Q08848	ENTREZGENE
	Q7TS57	ENTREZGENE, UniProtKB/TrEMBL
	STX2_RAT	UniProtKB/Swiss-Prot
UniProt Secondary	Q08846	UniProtKB/Swiss-Prot
	Q08847	UniProtKB/Swiss-Prot
	Q08848	UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2008-02-15	Stx2	syntaxin 2	Epim	epimorphin	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2002-06-10	Epim	Epimorphin			Symbol and Name status set to approved	70586	APPROVED

RGD Curation Notes

Note Type	Note	Reference
gene_transcript	four splice variants have nearly identical N-terminal cytoplasmic domains; syntaxins 2A and 2B have hydrophobic C-terminal domains while syntaxins 2C and 2D have hydrophillic C-terminal domains	1298910

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Send us a Message

Imported Disease Annotations - CTD