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Gene: Kcnh8 (potassium voltage-gated channel subfamily H member 8) Rattus norvegicus

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Symbol:

Kcnh8

Name:

potassium voltage-gated channel subfamily H member 8

RGD ID:

2549

Description:

Enables RNA polymerase II cis-regulatory region sequence-specific DNA binding activity and delayed rectifier potassium channel activity. Involved in negative regulation of apoptotic process; potassium ion transport; and response to aldosterone. Predicted to be located in membrane. Predicted to be part of monoatomic ion channel complex. Predicted to be active in plasma membrane. Biomarker of retinal degeneration. Orthologous to human KCNH8 (potassium voltage-gated channel subfamily H member 8); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil; alpha-Zearalanol.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

ELK channel 3; Elk1; ELK1, member of ETS oncogene family; ELK3; ether-a-go-go-like potassium channel 1; ether-a-go-go-like potassium channel 3; Ets-1; potassium channel, voltage gated eag related subfamily H, member 8; potassium voltage-gated channel, subfamily H (eag-related), member 8; potassium voltage-gated channel, subfamily H, member 8; RELK3; voltage-gated delayed rectifier potassium channel KCNH8; voltage-gated potassium channel subunit Kv12.1

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	9	5,742,683 - 6,182,445 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	9	5,742,683 - 6,182,445 (+)	Ensembl				GRCr8
mRatBN7.2	9	5,506,044 - 5,945,828 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	9	5,506,044 - 5,945,828 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	9	6,689,591 - 7,118,139 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	9	11,849,156 - 12,275,677 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	9	10,982,526 - 11,409,023 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	9	3,127,618 - 3,697,736 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	9	3,127,618 - 3,697,736 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	9	37,051,521 - 37,151,913 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
Rnor_5.0	9	37,189,122 - 37,426,999 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	9	2,085,695 - 2,546,505 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	9	2,380,584 - 2,807,223 (+)	NCBI		Celera
RGSC_v3.1	9	2,085,694 - 2,546,505 (-)	NCBI
Cytogenetic Map	9	q11	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

progressive myoclonus epilepsy 4 (ISO)

retinal degeneration (IEP)

RETINAL DYSTROPHY WITH INNER RETINAL DYSFUNCTION AND GANGLION CELL ABNORMALITIES (IEP)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,1-dichloroethene (ISO)

1,2-dimethylhydrazine (ISO)

17beta-estradiol (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP)

6-propyl-2-thiouracil (EXP)

aflatoxin B1 (ISO)

alpha-Zearalanol (EXP)

ammonium chloride (EXP)

arsenite(3-) (ISO)

benzo[a]pyrene (ISO)

benzo[e]pyrene (ISO)

beta-lapachone (ISO)

bisphenol A (EXP,ISO)

bisphenol F (ISO)

Butylbenzyl phthalate (ISO)

CGP 52608 (ISO)

DDT (EXP)

Diallyl sulfide (ISO)

epoxiconazole (ISO)

GW 4064 (ISO)

lead(0) (ISO)

methapyrilene (ISO)

methoxychlor (EXP)

N,N-diethyl-m-toluamide (EXP)

N-Nitrosopyrrolidine (ISO)

nickel atom (ISO)

O-methyleugenol (ISO)

okadaic acid (ISO)

paracetamol (ISO)

perfluorooctanoic acid (EXP)

permethrin (EXP)

trichostatin A (ISO)

valproic acid (ISO)

vinclozolin (EXP)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

monoatomic ion transmembrane transport (IEA)

monoatomic ion transport (IEA)

negative regulation of apoptotic process (IMP)

potassium ion transmembrane transport (IBA,IEA)

potassium ion transport (IDA,IEA,ISO)

regulation of membrane potential (IBA)

response to aldosterone (IEP)

transmembrane transport (IEA)

Cellular Component

membrane (IEA)

monoatomic ion channel complex (IEA)

plasma membrane (IBA,IEA,ISO)

Molecular Function

delayed rectifier potassium channel activity (IDA,IEA,ISO)

monoatomic ion channel activity (IEA)

potassium channel activity (IEA)

RNA polymerase II cis-regulatory region sequence-specific DNA binding (IMP)

voltage-gated potassium channel activity (IBA,IEA,IMP)

References

References - curated

#	Reference Title	Reference Citation
1.	Effects of provirus integration in the Tpl-1/Ets-1 locus in Moloney murine leukemia virus-induced rat T-cell lymphomas: levels of expression, polyadenylation, transcriptional initiation, and differential splicing of the Ets-1 mRNA.	Bellacosa A, etal., J Virol 1994 Apr;68(4):2320-30.
2.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
4.	Gene expression changes in the retina after systemic administration of aldosterone.	Ono A, etal., Jpn J Ophthalmol. 2018 Jul;62(4):499-507. doi: 10.1007/s10384-018-0595-4. Epub 2018 Apr 30.
5.	GOA pipeline	RGD automated data pipeline
6.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
7.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
8.	Cloning of a mammalian elk potassium channel gene and EAG mRNA distribution in rat sympathetic ganglia.	Shi W, etal., J Physiol 1998 Sep 15;511 ( Pt 3):675-82.
9.	Ets-1 protects vascular smooth muscle cells from undergoing apoptosis by activating p21WAF1/Cip1: ETS-1 regulates basal and and inducible p21WAF1/Cip: ETS-1 regulates basal and inducible p21WAF1/Cip1 transcription via distinct cis-acting elements in the p21WAF/Cip1 promoter.	Zhang C, etal., J Biol Chem 2003 Jul 25;278(30):27903-9. Epub 2003 May 9.

Additional References at PubMed

PMID:9824707	PMID:10718922	PMID:11425889	PMID:18650019

Genomics

Comparative Map Data

Kcnh8
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	9	5,742,683 - 6,182,445 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	9	5,742,683 - 6,182,445 (+)	Ensembl				GRCr8
mRatBN7.2	9	5,506,044 - 5,945,828 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	9	5,506,044 - 5,945,828 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	9	6,689,591 - 7,118,139 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	9	11,849,156 - 12,275,677 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	9	10,982,526 - 11,409,023 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	9	3,127,618 - 3,697,736 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	9	3,127,618 - 3,697,736 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	9	37,051,521 - 37,151,913 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
Rnor_5.0	9	37,189,122 - 37,426,999 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	9	2,085,695 - 2,546,505 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	9	2,380,584 - 2,807,223 (+)	NCBI		Celera
RGSC_v3.1	9	2,085,694 - 2,546,505 (-)	NCBI
Cytogenetic Map	9	q11	NCBI

KCNH8
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	3	19,148,510 - 19,535,642 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	3	19,148,102 - 19,535,642 (+)	Ensembl			hg38	GRCh38
GRCh37	3	19,190,002 - 19,577,134 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	3	19,165,021 - 19,552,139 (+)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	3	19,165,020 - 19,552,139	NCBI
Celera	3	19,130,110 - 19,517,673 (+)	NCBI		Celera
Cytogenetic Map	3	p24.3	NCBI
HuRef	3	19,128,776 - 19,516,250 (+)	NCBI		HuRef
CHM1_1	3	19,142,402 - 19,529,363 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	3	19,152,636 - 19,539,692 (+)	NCBI		T2T-CHM13v2.0

Kcnh8
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	17	52,909,535 - 53,286,892 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	17	52,909,737 - 53,286,222 (+)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	17	52,602,709 - 52,979,194 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	17	52,602,709 - 52,979,194 (+)	Ensembl			mm10	GRCm38
MGSCv37	17	52,742,088 - 53,047,981 (+)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	17	52,067,692 - 52,370,148 (+)	NCBI		MGSCv36	mm8
Celera	17	56,055,463 - 56,433,023 (+)	NCBI		Celera
Cytogenetic Map	17	C	NCBI
cM Map	17	27.37	NCBI

Kcnh8
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955430	11,298,850 - 11,654,835 (+)	Ensembl
ChiLan1.0	NW_004955430	11,298,850 - 11,654,835 (+)	NCBI	ChiLan1.0	ChiLan1.0

KCNH8
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	2	19,111,362 - 19,509,419 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	3	19,116,136 - 19,510,265 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	3	19,063,663 - 19,461,752 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	3	19,394,151 - 19,789,436 (+)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	3	19,498,421 - 19,787,890 (+)	Ensembl			panPan2	panpan1.1

KCNH8
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	23	23,618,496 - 23,984,735 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	23	23,623,031 - 23,985,414 (-)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	23	23,644,427 - 24,013,714 (-)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	23	24,105,450 - 24,472,257 (-)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	23	24,106,815 - 24,472,210 (-)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	23	23,817,810 - 24,187,041 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	23	23,883,381 - 24,253,038 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	23	24,131,397 - 24,497,645 (-)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Kcnh8
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405118	178,477,275 - 178,816,811 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936473	11,616,090 - 11,953,811 (+)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936473	11,615,877 - 11,954,377 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

KCNH8
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	13	6,104,537 - 6,532,592 (+)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	13	6,104,382 - 6,533,505 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	13	7,344,982 - 7,490,449 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

KCNH8
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	15	63,954,331 - 64,334,300 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
Vero_WHO_p1.0	NW_023666041	36,964,409 - 37,361,199 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Kcnh8
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624821	4,475,250 - 4,832,194 (+)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624821	4,475,305 - 4,831,444 (+)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Kcnh8
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	4	89,714,961 - 90,297,190 (+)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Kcnh8
4131 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	221
Count of miRNA genes:	149
Interacting mature miRNAs:	174
Transcripts:	ENSRNOT00000017246
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
61425	Cia15	Collagen induced arthritis QTL 15	4.6		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	9	5346479	50416711	Rat
631211	Bw4	Body weight QTL4	5.31		retroperitoneal fat pad mass (VT:0010430)	retroperitoneal fat pad weight to body weight ratio (CMO:0000635)	9	5346479	50346479	Rat
70226	Eae4	Experimental allergic encephalomyelitis QTL 4			nervous system integrity trait (VT:0010566)	experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)	9	5474096	6714888	Rat
631533	Iresp3	Immunoglobin response QTL3	16.2		blood immunoglobulin E amount (VT:0002492)	serum immunoglobulin E level (CMO:0002101)	9	1	6094576	Rat
10054141	Gmadr4	Adrenal mass QTL 4	2.45	0.0074	adrenal gland mass (VT:0010420)	both adrenal glands wet weight (CMO:0000164)	9	1	21707400	Rat
9589158	Gluco65	Glucose level QTL 65	6.82	0.001	blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	9	496645	45496645	Rat
7411592	Foco8	Food consumption QTL 8	7.4	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	9	496645	45496645	Rat
7207814	Bmd91	Bone mineral density QTL 91	3.5		femur size trait (VT:1000369)	femoral neck cross-sectional area (CMO:0001697)	9	1	31250552	Rat
1578675	Bss17	Bone structure and strength QTL 17	3.8		femur morphology trait (VT:0000559)	femoral neck cortical cross-sectional area (CMO:0001702)	9	3605355	21031556	Rat
9589055	Scfw5	Subcutaneous fat weight QTL 5	5.55	0.001	subcutaneous adipose mass (VT:1000472)	abdominal subcutaneous fat pad weight (CMO:0002069)	9	496645	45496645	Rat
1300124	Cm4	Cardiac mass QTL 4	3.55		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	9	1	41763315	Rat

Markers in Region

D9Mgh5

Rat Assembly	Chr	Position (strand)	Source	JBrowse
GRCr8	9	6,094,409 - 6,094,576 (+)	Marker Load Pipeline
mRatBN7.2	9	5,857,783 - 5,857,951 (-)	MAPPER	mRatBN7.2
Rnor_6.0	9	3,309,754 - 3,309,921	NCBI	Rnor6.0
Rnor_5.0	9	37,250,734 - 37,250,901	UniSTS	Rnor5.0
RGSC_v3.4	9	2,176,482 - 2,176,650	RGD	RGSC3.4
RGSC_v3.4	9	2,176,483 - 2,176,650	UniSTS	RGSC3.4
Celera	9	2,719,700 - 2,719,867	UniSTS
RGSC_v3.1	9	2,176,482 - 2,176,650	RGD
Cytogenetic Map	9	q11	UniSTS

D9Rat139

Rat Assembly	Chr	Position (strand)	Source	JBrowse
GRCr8	9	6,096,320 - 6,096,447 (+)	Marker Load Pipeline
mRatBN7.2	9	5,859,695 - 5,859,822 (-)	MAPPER	mRatBN7.2
Rnor_6.0	9	3,307,883 - 3,308,009	NCBI	Rnor6.0
Rnor_5.0	9	37,252,646 - 37,252,772	UniSTS	Rnor5.0
RGSC_v3.4	9	2,174,612 - 2,174,738	UniSTS	RGSC3.4
RGSC_v3.4	9	2,174,611 - 2,174,738	RGD	RGSC3.4
Celera	9	2,721,612 - 2,721,738	UniSTS
RGSC_v3.1	9	2,174,611 - 2,174,738	RGD
SHRSP x BN Map	9	1.2299	RGD
SHRSP x BN Map	9	1.2299	UniSTS
Cytogenetic Map	9	q11	UniSTS

D9Got9

Rat Assembly	Chr	Position (strand)	Source	JBrowse
GRCr8	9	6,136,848 - 6,136,993 (+)	Marker Load Pipeline
mRatBN7.2	9	5,900,227 - 5,900,374 (-)	MAPPER	mRatBN7.2
Rnor_6.0	9	3,173,056 - 3,173,200	NCBI	Rnor6.0
Rnor_5.0	9	37,381,417 - 37,381,561	UniSTS	Rnor5.0
RGSC_v3.4	9	2,131,145 - 2,131,290	RGD	RGSC3.4
RGSC_v3.4	9	2,131,146 - 2,131,290	UniSTS	RGSC3.4
Celera	9	2,762,102 - 2,762,246	UniSTS
RGSC_v3.1	9	2,131,145 - 2,131,290	RGD
Cytogenetic Map	9	q11	UniSTS

AU046569

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	9	5,562,224 - 5,562,477 (-)	MAPPER	mRatBN7.2
Rnor_6.0	9	3,641,038 - 3,641,288	NCBI	Rnor6.0
Celera	9	2,434,429 - 2,434,680	UniSTS
Cytogenetic Map	9	q11	UniSTS

RH143692

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	9	5,832,748 - 5,832,881 (-)	MAPPER	mRatBN7.2
Rnor_6.0	9	3,334,512 - 3,334,644	NCBI	Rnor6.0
Rnor_5.0	9	37,226,882 - 37,227,014	UniSTS	Rnor5.0
RGSC_v3.4	9	2,202,211 - 2,202,343	UniSTS	RGSC3.4
Celera	9	2,693,944 - 2,694,076	UniSTS
Cytogenetic Map	9	q11	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
15	6	21	126	45	41	13	15	13	6	131	58	2	112	39	85	28	10	10

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_145095	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AF061957	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AJ007632	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH474081	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000009	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000087331 ⟹ ENSRNOP00000074122

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	9	5,742,683 - 6,182,445 (+)	Ensembl
mRatBN7.2 Ensembl	9	5,506,044 - 5,945,828 (+)	Ensembl
Rnor_6.0 Ensembl	9	3,127,618 - 3,697,736 (-)	Ensembl

RefSeq Acc Id:

NM_145095 ⟹ NP_659563

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	9	5,742,683 - 6,182,445 (+)	NCBI
mRatBN7.2	9	5,506,044 - 5,945,828 (+)	NCBI
Rnor_6.0	9	3,127,618 - 3,697,736 (-)	NCBI
Rnor_5.0	9	37,051,521 - 37,151,913 (+)	NCBI
Rnor_5.0	9	37,189,122 - 37,426,999 (+)	NCBI
RGSC_v3.4	9	2,085,695 - 2,546,505 (-)	RGD
Celera	9	2,380,584 - 2,807,223 (+)	RGD

Sequence:

show sequence

ATCCTTGTGGACAAACTTTGATGGGGAATTTCACACAGCGCTGGAAAAATGCCGGTTATGAAAG
GATTGCTGGCGCCACAGAACACCTTCCTGGACACTATTGCCACCCGTTTCGACGGAACACATAG
CAACTTCATCCTGGCCAATGCCCAAGTGGCAAAAGGTTTCCCCATAGTCTACTGTTCAGATGGC
TTCTGTGAGCTGGCTGGGTTTGCTCGAACTGAAGTCATGCAGAAGAGTTGCAGCTGCAAGTTTC
TGTTTGGGGTGGAGACCAACGAGCAGCTGATGCTTCAGATCGAAAAGTCCCTGGAGGAGAAGGT
AGAGTTCAAAGGAGAAATTATGTTCTACAAGAAGAATGGGGCTCCATTTTGGTGCCTGTTGGAT
ATCGTTCCTATAAAGAATGAGAAAGGAGATGTGGTCCTTTTCCTGGCCTCATTCAAAGATATAA
CAGACACGAAAGTGAAGATTACTTCAGAAGATAAAAAAGAAGACAGAGCCAAAGGAAGATCAAG
AGCAGGGAGCCACTTCGACTCAGCCCGCAGACGGAGCCGAGCAGTCCTTTATCACATCTCAGGA
CACCTGCAAAGAAGAGAAAAGAACAAATTGAAAATAAATAATAACGTGTTTGTAGATAAACCGG
CGTTTCCAGAGTATAAGGTTTCCGATGCAAAAAAGTCCAAGTTCATCCTGCTGCACTTCAGCAC
TTTTAAAGCTGGCTGGGACTGGCTCATTTTGCTGGCAACGTTTTATGTTGCTGTGACAGTCCCT
TACAACGTGTGCTTCATTGGCAATGAGGATCTGTCCACAACTCGGAGCACAACGGTCAGTGACA
TCGCTGTGGAGATTCTCTTCATTATAGATATTATTCTAAATTTCCGAACAACTTATGTCAGCAA
GTCTGGCCAAGTTATCTTTGAAGCGAGATCCATTTGCATCCACTACGTCACCACCTGGTTCATC
ATTGATCTGATTGCTGCCCTGCCCTTTGACCTCCTGTATGCTTTCAATGTCACAGTGGTGTCCC
TCGTACATCTTCTGAAGACTGTTCGGCTGCTCCGTCTTTTGCGCCTCCTGCAGAAGCTGGACCG
TTATTCTCAGCACAGCACAATTGTCCTCACCCTGCTCATGTCCATGTTTGCTCTCCTTGCACAC
TGGATGGCATGTATCTGGTATGTCATTGGAAAAATGGAGAGGGAGGACAACAGCCTTCTCAAGT
GGGAAGTCGGTTGGCTTCACGAGCTGGGAAAGAGACTGGAATCTCCGTACTACGGCAACAACAC
GCTGGGCGGCCCGTCCATCCGCAGTGCCTATATCGCAGCCTTGTACTTCACTCTCAGCAGCCTC
ACCAGCGTGGGATTTGGGAATGTGTCCGCTAACACGGATGCAGAGAAGATCTTCTCCATCTGTA
CCATGTTGATTGGAGCCCTGATGCATGCCTTGGTATTTGGGAATGTGACTGCCATCATACAGAG
AATGTACTCTAGATGGAGCCTGTACCATACTAGAACCAAGGACCTAAAGGACTTCATCCGTGTG
CATCACCTGCCCCAGCAACTCAAGCAGAGGATGCTTGAGTACTTTCAGACAACTTGGTCTGTCA
ACAATGGAATAGATTCAAATGAGCTTTTGAAAGACTTTCCAGATGAGCTGCGCTCTGACATCAC
AATGCATCTGAACAAGGAGATCTTACAGCTGTCCCTGTTTGAATGTGCTAGCCGGGGCTGCCTC
AGGTCTCTGTCTCTCCATATTAAAACCTCATTCTGTGCCCCAGGAGAGTATCTGCTGCGCCAGG
GAGATGCGTTGCAGGCCATCTACTTCGTGTGCTCAGGCTCTATGGAGGTTCTTAAAGACAGCAT
GGTGTTGGCTATTCTAGGGAAGGGGGATTTAATTGGAGCAAATTTATCAATTAAAGACCAAGTG
ATCAAGACCAACGCTGACGTGAAGGCTCTGACCTACTGTGATCTACAGTGCATCATCCTGAAAG
GTCTCTTTGAGGTGCTGGGCCTTTACCCAGAGTACGCACACAAATTCGTAGAAGACATCCAGCA
CGACCTCACATACAACCTTCGAGAAGGTCATGAGAGTGATGTAATATCAAGATTATCGAACAAA
TCTACAGTCCCACAGGCAGAGCCCAAGGGGAATGGAAGCATCAAGAAGAGACTCCCATCCATTG
TGGAAGATGAGGAAGAGGAGGAAGTGGAGGAAGAGGAGACCACCTCCCTTTCTCCCATCTACAC
AAGGGGATCCTCTGTTTCACACAGCAAAAAGACTGGAAGCAGTAAGAGCTATCTAGGTTTGAGC
TTAAAGCAACTGACCTCAGGAACAGTTCCATTCCACTCACCTATCAGAGTCTCCAGTGCCAACT
CCCCTAAAACCAAGCAGGAAGCTGACCCACCTAACCATGGCACACGGAAAGAGAAGAATCTGAA
AGTTCAGCTCTGCAGCCTGGGTACTGCTGGAACCCCAGAGCTCAGTCCGAGGATTGTCGATGGA
ATTGAAGATGGCAACAGCAGTGAGGAAACTCAGACTTTTGATTTTGGCTCTGAACAAATCAGGC
CAGAGCCCAGGATTTCCCCTTCCCTTGGAGAATCAGAGATTGGAGCTGCGTTTCTGTTCATCAA
GGCTGAAGAAACCAAGCAGCAGATAAACAAGCTCAACAGTGAGGTCACAACATTGACTCAGGAG
GTCTCCCAGCTAGGGAAAGATATGAGAAGCATCATGCAACTTCTGGAAAACATCTTGTCACCTC
AGCAGCCATCACAATTTTGTTCTCTGCATCCCACTTCAATCTGTCCTTCCAGAGAAAGTTTCCA
GACTAGGGTGAGCTGGAGTGCTCACCAGCCTTGCCTACACTTGCAGGCAAATGGAGCACATCTT
TACCATGGCAATGTCACCTCTGACATCTGGAGTGTCGACCCCTCCTTGGTGGGCAGCAACCCTC
AACGAACTGAAGCTCATGAGCAAAGTCCAGTAGATAGTGAACTGCATCATTCTCCAAACCTGGC
TTATTCCCCCTCTCACTGCCAGGTTATCCAAGAAGGCCACTTGCAGTTCCTAAGGTGCATCTCC
CCTCATTCAGATACCACACTGACACCTTTGCAGTCCATCTCAGCCACTCTCTCATCCTCTGTGT
GCTCCTCATCAGAAACATCCTTGCACCTCGTTCTCCCAAGTAGGTCAGAGGAGGGCAGCATCAC
TCATGGACCTGTGAGTTCTTTCAGTTTGGAAAACTTACCAGGATCTTGGGACCGAGAAGGAATG
ATGTCAGCCTCTACAGAACCCTTGGAGAACTTTCCAGTAGAAGTTGTCACAAGCACAGCGGATG
TAAAAGACAGCAAAGCCATAAACGTATAATATCAGCACATAAGGGCAGCTTTCAATGCCAAATC
CACTGCTGCATGACAGCTCTAGTTTGCCTTTGTGGCTTCTAGCAGGTGTGGAGCCTGAGCAAAG
TTAGGAATTCTGCAGGAAAGAGGGCAAGGGGCCAGTAAAAGGCAGAGCCACCTCTATACTGTAG
CAAACAATTTCTAGATCGTAGAAGCATAAAACCTTTTCTGTACAGGTATTAACTTACTGGTCTG
ATTGACAGACTTTGGTAACAATCCTATGACCCAGAGGGTCTGAGCAGATAGAAACCCCAGACAA
AGAGTTTGGGGATTAGTTTTGTCATAAGTGGATTTTTTTGTGAAGTGCAGCAAAGGTTTTTTTT
CCTGAGTGCCTGGTTGTCATTCCTGAA

hide sequence

Protein Sequences


Protein RefSeqs	NP_659563	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAC61520	(Get FASTA)	NCBI Sequence Viewer
	CAA07591	(Get FASTA)	NCBI Sequence Viewer
	EDL83034	(Get FASTA)	NCBI Sequence Viewer
	EDL83035	(Get FASTA)	NCBI Sequence Viewer
	EDL83036	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000074122
GenBank Protein	Q9QWS8	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_659563 ⟸ NM_145095

- UniProtKB:

Q9QWS8 (UniProtKB/Swiss-Prot), O88877 (UniProtKB/Swiss-Prot), A6KPQ1 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MPVMKGLLAPQNTFLDTIATRFDGTHSNFILANAQVAKGFPIVYCSDGFCELAGFARTEVMQKS
CSCKFLFGVETNEQLMLQIEKSLEEKVEFKGEIMFYKKNGAPFWCLLDIVPIKNEKGDVVLFLA
SFKDITDTKVKITSEDKKEDRAKGRSRAGSHFDSARRRSRAVLYHISGHLQRREKNKLKINNNV
FVDKPAFPEYKVSDAKKSKFILLHFSTFKAGWDWLILLATFYVAVTVPYNVCFIGNEDLSTTRS
TTVSDIAVEILFIIDIILNFRTTYVSKSGQVIFEARSICIHYVTTWFIIDLIAALPFDLLYAFN
VTVVSLVHLLKTVRLLRLLRLLQKLDRYSQHSTIVLTLLMSMFALLAHWMACIWYVIGKMERED
NSLLKWEVGWLHELGKRLESPYYGNNTLGGPSIRSAYIAALYFTLSSLTSVGFGNVSANTDAEK
IFSICTMLIGALMHALVFGNVTAIIQRMYSRWSLYHTRTKDLKDFIRVHHLPQQLKQRMLEYFQ
TTWSVNNGIDSNELLKDFPDELRSDITMHLNKEILQLSLFECASRGCLRSLSLHIKTSFCAPGE
YLLRQGDALQAIYFVCSGSMEVLKDSMVLAILGKGDLIGANLSIKDQVIKTNADVKALTYCDLQ
CIILKGLFEVLGLYPEYAHKFVEDIQHDLTYNLREGHESDVISRLSNKSTVPQAEPKGNGSIKK
RLPSIVEDEEEEEVEEEETTSLSPIYTRGSSVSHSKKTGSSKSYLGLSLKQLTSGTVPFHSPIR
VSSANSPKTKQEADPPNHGTRKEKNLKVQLCSLGTAGTPELSPRIVDGIEDGNSSEETQTFDFG
SEQIRPEPRISPSLGESEIGAAFLFIKAEETKQQINKLNSEVTTLTQEVSQLGKDMRSIMQLLE
NILSPQQPSQFCSLHPTSICPSRESFQTRVSWSAHQPCLHLQANGAHLYHGNVTSDIWSVDPSL
VGSNPQRTEAHEQSPVDSELHHSPNLAYSPSHCQVIQEGHLQFLRCISPHSDTTLTPLQSISAT
LSSSVCSSSETSLHLVLPSRSEEGSITHGPVSSFSLENLPGSWDREGMMSASTEPLENFPVEVV
TSTADVKDSKAINV

hide sequence

Ensembl Acc Id:

ENSRNOP00000074122 ⟸ ENSRNOT00000087331

Protein Domains

Cyclic nucleotide-binding PAC PAS

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q9QWS8-F1-model_v2	AlphaFold	Q9QWS8	1-1102	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:2549	AgrOrtholog
BioCyc Gene	G2FUF-28415	BioCyc
Ensembl Genes	ENSRNOG00000058626	Ensembl, ENTREZGENE
Ensembl Transcript	ENSRNOT00000087331	ENTREZGENE
Gene3D-CATH	1.10.1200.260	UniProtKB/Swiss-Prot
	1.10.287.70	UniProtKB/Swiss-Prot
	2.60.120.10	UniProtKB/Swiss-Prot
	PAS domain	UniProtKB/Swiss-Prot
InterPro	cNMP-bd-like	UniProtKB/Swiss-Prot
	cNMP-bd_dom	UniProtKB/Swiss-Prot
	Ion_trans_dom	UniProtKB/Swiss-Prot
	K_chnl_volt-dep_EAG/ELK/ERG	UniProtKB/Swiss-Prot
	K_chnl_volt-dep_ELK	UniProtKB/Swiss-Prot
	KCNH_channel	UniProtKB/Swiss-Prot
	PAC	UniProtKB/Swiss-Prot
	PAS	UniProtKB/Swiss-Prot
	PAS-assoc_C	UniProtKB/Swiss-Prot
	PAS-like_dom_sf	UniProtKB/Swiss-Prot
	RmlC-like_jellyroll	UniProtKB/Swiss-Prot
KEGG Report	rno:246325	UniProtKB/Swiss-Prot
NCBI Gene	Kcnh8	ENTREZGENE
PANTHER	POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY H MEMBER 8	UniProtKB/Swiss-Prot
	VOLTAGE AND LIGAND GATED POTASSIUM CHANNEL	UniProtKB/Swiss-Prot
Pfam	cNMP_binding	UniProtKB/Swiss-Prot
	Ion_trans	UniProtKB/Swiss-Prot
	PAS_9	UniProtKB/Swiss-Prot
PhenoGen	Kcnh8	PhenoGen
PRINTS	EAGCHANLFMLY	UniProtKB/Swiss-Prot
	ELKCHANNEL	UniProtKB/Swiss-Prot
PROSITE	CNMP_BINDING_3	UniProtKB/Swiss-Prot
	PAC	UniProtKB/Swiss-Prot
RatGTEx	ENSRNOG00000058626	RatGTEx
SMART	cNMP	UniProtKB/Swiss-Prot
	PAC	UniProtKB/Swiss-Prot
Superfamily-SCOP	SSF51206	UniProtKB/Swiss-Prot
	SSF55785	UniProtKB/Swiss-Prot
	Voltage-gated potassium channels	UniProtKB/Swiss-Prot
UniProt	A0A0G2K7A0_RAT	UniProtKB/TrEMBL
	A6KPQ1	ENTREZGENE, UniProtKB/TrEMBL
	A6KPQ2_RAT	UniProtKB/TrEMBL
	A6KPQ3_RAT	UniProtKB/TrEMBL
	KCNH8_RAT	UniProtKB/Swiss-Prot
	O88877	ENTREZGENE
	Q9QWS8	ENTREZGENE
UniProt Secondary	O88877	UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2016-02-11	Kcnh8	potassium voltage-gated channel subfamily H member 8	Kcnh8	potassium channel, voltage gated eag related subfamily H, member 8	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2015-01-26	Kcnh8	potassium channel, voltage gated eag related subfamily H, member 8	Kcnh8	potassium voltage-gated channel, subfamily H (eag-related), member 8	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2006-03-30	Kcnh8	potassium voltage-gated channel, subfamily H (eag-related), member 8	Elk1	ELK1, member of ETS oncogene family	Symbol and Name updated	1299863	APPROVED
2002-06-10	Elk1	ELK1			Symbol and Name status set to approved	70586	APPROVED

RGD Curation Notes

Note Type	Note	Reference
gene_disease	target of pro-viral insertion during Moloney murine leukemia virus-induced T-cell lymphoma progression	728601
gene_expression	MML pro-viral insertion enhances expression	728601
gene_function	involved in cell cycle regulation	728601
gene_function	transcription factor	728601
gene_function	induces proliferation in vascular smooth muscle cells	1298911
gene_physical_interaction	binds CREB Binding Protein/p300 (CBP/p300) to activate transcription of p21WAF1/Cip1 at the Ets enhancer element (-1350GGAA-1347) in the promoter region	1298911
gene_process	may activate p21WAF1/Cip1 to protect vascular smooth muscle cells from undergoing apoptosis	1298911
gene_regulation	regulates p21WAF1/Cip1 to inhibit apoptosis in vascular smooth muscle cells	1298911

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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