Cyp2f4 (cytochrome P450, family 2, subfamily f, polypeptide 4) - Rat Genome Database

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Gene: Cyp2f4 (cytochrome P450, family 2, subfamily f, polypeptide 4) Rattus norvegicus
Analyze
Symbol: Cyp2f4
Name: cytochrome P450, family 2, subfamily f, polypeptide 4
RGD ID: 2476
Description: Enables monooxygenase activity. Involved in trichloroethylene metabolic process. Predicted to be located in endoplasmic reticulum membrane. Predicted to be active in cytoplasm. Orthologous to human CYP2F1 (cytochrome P450 family 2 subfamily F member 1); PARTICIPATES IN phase I biotransformation pathway via cytochrome P450; INTERACTS WITH (+)-schisandrin B; 1,1-dichloroethene; 1-nitronaphthalene.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Cyp2f1; Cyp2f2; CYP4502F4; CYPIIF2; cytochrome P450 2F2; Cytochrome P450 subfamily IIF polypeptide 1; cytochrome P450, family 2, subfamily f, polypeptide 2; cytochrome P450, subfamily 2F, polypeptide 1; Cytochrome P450, subfamily IIF, polypeptide 1; cytochrome P450-NAH-2; naphthalene dehydrogenase; naphthalene hydroxylase; P450-NAH-2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8191,543,768 - 91,557,553 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl191,543,768 - 91,557,553 (+)EnsemblGRCr8
mRatBN7.2182,416,107 - 82,429,897 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl182,416,130 - 82,429,896 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx187,819,674 - 87,833,401 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0196,305,887 - 96,319,672 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0189,575,540 - 89,589,267 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0183,933,974 - 83,947,804 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl183,933,942 - 83,947,821 (+)Ensemblrn6Rnor6.0
Rnor_5.0185,144,699 - 85,158,525 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4182,191,741 - 82,204,629 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera176,831,247 - 76,843,408 (+)NCBICelera
RGSC_v3.1182,269,851 - 82,282,739 (+)NCBI
RH 3.4 Map1841.6RGD
Cytogenetic Map1q21NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(S)-amphetamine  (ISO)
1,1-dichloroethene  (EXP,ISO)
1,2-dimethylhydrazine  (ISO)
1-aminobenzotriazole  (ISO)
1-naphthyl isothiocyanate  (ISO)
1-nitronaphthalene  (EXP,ISO)
1-Phenyl-1,2-ethanediol  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
1H-pyrazole  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2-palmitoylglycerol  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3-methyleneindolenine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-(ethoxymethylene)-2-phenyloxazol-5-one  (ISO)
4-hydroxystyrene  (ISO)
5-fluorouracil  (ISO)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (EXP)
6-propyl-2-thiouracil  (EXP,ISO)
8-Br-cAMP  (ISO)
acetamide  (EXP)
acrylamide  (EXP)
actinomycin D  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
alpha-naphthoflavone  (ISO)
amiodarone  (EXP)
ammonium chloride  (EXP)
atrazine  (ISO)
benzbromarone  (EXP)
benzene  (ISO)
benzo[a]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
Butylbenzyl phthalate  (ISO)
cadmium dichloride  (ISO)
carbon nanotube  (ISO)
clofibrate  (EXP,ISO)
crocidolite asbestos  (ISO)
cycloheximide  (ISO)
cylindrospermopsin  (ISO)
dexamethasone  (ISO)
dibenzofuran  (EXP)
dibutyl phthalate  (ISO)
dicyclanil  (ISO)
diethyl phthalate  (ISO)
diethylstilbestrol  (ISO)
diiodine  (ISO)
diisobutyl phthalate  (ISO)
diisononyl phthalate  (ISO)
diquat  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
epoxiconazole  (ISO)
fenofibrate  (EXP)
finasteride  (EXP)
fluensulfone  (ISO)
flurbiprofen  (ISO)
flutamide  (EXP)
gefitinib  (ISO)
indometacin  (EXP)
inulin  (ISO)
kojic acid  (EXP)
L-ethionine  (EXP)
lycopene  (ISO)
methapyrilene  (EXP)
mono(2-ethylhexyl) phthalate  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
naphthalene  (EXP,ISO)
naphthalene 1,2-oxide  (EXP)
nickel atom  (ISO)
nickel sulfate  (ISO)
nonanoic acid  (ISO)
ochratoxin A  (EXP)
oleanolic acid  (ISO)
omeprazole  (EXP)
ozone  (ISO)
paracetamol  (ISO)
paraquat  (EXP)
parathion  (ISO)
pentane-2,3-dione  (EXP)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (EXP,ISO)
Pf-06840003  (ISO)
phenobarbital  (EXP,ISO)
phenol  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
pirinixic acid  (EXP,ISO)
pregnenolone 16alpha-carbonitrile  (EXP,ISO)
rifampicin  (ISO)
rotenone  (EXP)
serpentine asbestos  (ISO)
sevoflurane  (EXP)
silver atom  (ISO)
silver(0)  (ISO)
skatole  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
styrene  (ISO)
styrene oxide  (ISO)
tamoxifen  (ISO)
tauroursodeoxycholic acid  (EXP)
tetrachloromethane  (EXP,ISO)
thioacetamide  (EXP)
titanium dioxide  (EXP,ISO)
toluene  (ISO)
toluene 2,4-diisocyanate  (ISO)
tremolite asbestos  (ISO)
trichloroethene  (EXP,ISO)
triphenyl phosphate  (EXP)
triptonide  (ISO)
vinclozolin  (EXP)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Bioactivation of the pulmonary toxicants naphthalene and 1-nitronaphthalene by rat CYP2F4. Baldwin RM, etal., J Pharmacol Exp Ther. 2005 Feb;312(2):857-65. Epub 2004 Oct 27.
2. Identification and cross-species comparisons of CYP2F subfamily genes in mammals. Chen N, etal., Mutat Res 2002 Feb 20;499(2):155-61.
3. Pulmonary bioactivation of trichloroethylene to chloral hydrate: relative contributions of CYP2E1, CYP2F, and CYP2B1. Forkert PG, etal., Drug Metab Dispos. 2005 Oct;33(10):1429-37. Epub 2005 Jun 29.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
6. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
7. High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
8. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
9. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
10. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
11. GOA pipeline RGD automated data pipeline
12. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
13. Comprehensive gene review and curation RGD comprehensive gene curation
14. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
15. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
Additional References at PubMed
PMID:10383923   PMID:15489334   PMID:16876762  


Genomics

Comparative Map Data
Cyp2f4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8191,543,768 - 91,557,553 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl191,543,768 - 91,557,553 (+)EnsemblGRCr8
mRatBN7.2182,416,107 - 82,429,897 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl182,416,130 - 82,429,896 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx187,819,674 - 87,833,401 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0196,305,887 - 96,319,672 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0189,575,540 - 89,589,267 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0183,933,974 - 83,947,804 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl183,933,942 - 83,947,821 (+)Ensemblrn6Rnor6.0
Rnor_5.0185,144,699 - 85,158,525 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4182,191,741 - 82,204,629 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera176,831,247 - 76,843,408 (+)NCBICelera
RGSC_v3.1182,269,851 - 82,282,739 (+)NCBI
RH 3.4 Map1841.6RGD
Cytogenetic Map1q21NCBI
CYP2F1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381941,114,432 - 41,128,381 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1941,114,432 - 41,128,381 (+)Ensemblhg38GRCh38
GRCh371941,620,337 - 41,634,286 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361946,312,193 - 46,326,121 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341946,312,192 - 46,326,121NCBI
Celera1938,420,521 - 38,434,443 (+)NCBICelera
Cytogenetic Map19q13.2NCBI
HuRef1938,052,253 - 38,066,192 (+)NCBIHuRef
CHM1_11941,620,070 - 41,634,000 (+)NCBICHM1_1
T2T-CHM13v2.01943,935,308 - 43,949,263 (+)NCBIT2T-CHM13v2.0
Cyp2f2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39726,819,380 - 26,833,085 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl726,819,334 - 26,833,085 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38727,119,955 - 27,133,660 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl727,119,909 - 27,133,660 (+)Ensemblmm10GRCm38
MGSCv37727,904,974 - 27,918,679 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36726,828,735 - 26,842,420 (+)NCBIMGSCv36mm8
Celera721,696,833 - 21,710,532 (+)NCBICelera
Cytogenetic Map7A3NCBI
cM Map715.82NCBI
LOC102004212
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955578531,353 - 541,684 (+)Ensembl
ChiLan1.0NW_004955578530,094 - 541,951 (+)NCBIChiLan1.0ChiLan1.0
CYP2F1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22047,333,165 - 47,355,081 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11949,201,512 - 49,223,265 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01938,124,921 - 38,137,574 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11946,632,134 - 46,644,048 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1946,632,134 - 46,643,748 (+)EnsemblpanPan2panpan1.1
CYP2F1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11112,973,776 - 112,986,419 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1112,974,847 - 112,986,123 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1112,376,173 - 112,388,674 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01113,572,083 - 113,584,693 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1113,573,209 - 113,584,285 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11113,131,608 - 113,144,122 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01112,763,587 - 112,776,096 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01113,757,678 - 113,770,190 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
CYP2F1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl649,017,008 - 49,029,388 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1649,014,912 - 49,032,207 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2644,701,834 - 44,707,747 (-)NCBISscrofa10.2Sscrofa10.2susScr3
LOC103235509
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1635,270,229 - 35,286,326 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366607313,409,873 - 13,430,845 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in Cyp2f4
54 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:166
Count of miRNA genes:126
Interacting mature miRNAs:133
Transcripts:ENSRNOT00000068690
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1578649Bmd8Bone mineral density QTL 84.9femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)151940904101229020Rat
1582234Gluco18Glucose level QTL 183.40.0003blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)187889942132889942Rat
1358359Sradr1Stress Responsive Adrenal Weight QTL 14.74adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)139728272132889942Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)151941022208479811Rat
1358192Ept13Estrogen-induced pituitary tumorigenesis QTL 133.4pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)186622262131622262Rat
6903308Scl36Serum cholesterol QTL 3620.0125blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)158769992103769992Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)151940904168768703Rat
2300164Bmd44Bone mineral density QTL 445.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)166077886111077886Rat
1331800Scl25Serum cholesterol level QTL 253.013blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)187785026142582336Rat
7421628Bp361Blood pressure QTL 3610.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183019780128019780Rat
152025249Scl82Serum cholesterol level QTL 824.77blood cholesterol amount (VT:0000180)152891222109116986Rat
631495Bp96Blood pressure QTL 964.52arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)166404680111404680Rat
10054135Gmadr2Adrenal mass QTL 21.970.0129adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)186993904131993904Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134184556172281316Rat
631512Scl6Serum cholesterol level QTL 69.6blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)18126986099645535Rat
7411712Strs4Sensitivity to stroke QTL 48.7cerebrum integrity trait (VT:0010549)percentage of study population developing cerebrovascular lesions during a period of time (CMO:0000932)187558587132558587Rat
2298545Neuinf8Neuroinflammation QTL 84.6nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)166009857160501508Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134565911208798288Rat
1302788Scl19Serum cholesterol QTL 194.60.001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)166400974132889942Rat
1549903Bp267Blood pressure QTL 267arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)184107164115183752Rat
2313083Bmd74Bone mineral density QTL 7440.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)191302413136302413Rat
2313402Anxrr24Anxiety related response QTL 24aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)151511344153680016Rat
61342Bp27Blood pressure QTL 273.40.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16540563796805205Rat

Markers in Region
RH94438  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2182,429,698 - 82,429,874 (+)MAPPERmRatBN7.2
Rnor_6.0183,947,606 - 83,947,781NCBIRnor6.0
Rnor_5.0185,158,327 - 85,158,502UniSTSRnor5.0
RGSC_v3.4182,204,431 - 82,204,606UniSTSRGSC3.4
Celera176,843,210 - 76,843,385UniSTS
RH 3.4 Map1841.6UniSTS
Cytogenetic Map1q21UniSTS
Cyp2f2  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8191,545,365 - 91,545,733 (+)Marker Load Pipeline
mRatBN7.2182,417,706 - 82,418,074 (+)MAPPERmRatBN7.2
Rnor_6.0183,935,615 - 83,935,982NCBIRnor6.0
Rnor_5.0185,146,335 - 85,146,702UniSTSRnor5.0
RGSC_v3.4182,191,802 - 82,192,169UniSTSRGSC3.4
Celera176,831,308 - 76,831,675UniSTS
Cytogenetic Map1q21UniSTS
G67797  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2182,425,743 - 82,426,180 (+)MAPPERmRatBN7.2
Rnor_6.0183,943,651 - 83,944,087NCBIRnor6.0
Rnor_5.0185,154,372 - 85,154,808UniSTSRnor5.0
Celera176,839,264 - 76,839,700UniSTS
Cytogenetic Map1q21UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
15 11 24 52 90 89 59 38 59 6 241 87 2 31 72 79 30 3 3

Sequence


Ensembl Acc Id: ENSRNOT00000068690   ⟹   ENSRNOP00000058858
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl191,543,768 - 91,557,553 (+)Ensembl
mRatBN7.2 Ensembl182,416,130 - 82,429,896 (+)Ensembl
Rnor_6.0 Ensembl183,933,942 - 83,947,821 (+)Ensembl
RefSeq Acc Id: NM_019303   ⟹   NP_062176
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8191,543,768 - 91,557,553 (+)NCBI
mRatBN7.2182,416,107 - 82,429,897 (+)NCBI
Rnor_6.0183,935,554 - 83,947,804 (+)NCBI
Rnor_5.0185,144,699 - 85,158,525 (+)NCBI
RGSC_v3.4182,191,741 - 82,204,629 (+)RGD
Celera176,831,247 - 76,843,408 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_062176 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAB70259 (Get FASTA)   NCBI Sequence Viewer  
  AAH70939 (Get FASTA)   NCBI Sequence Viewer  
  EDM07975 (Get FASTA)   NCBI Sequence Viewer  
  EDM07976 (Get FASTA)   NCBI Sequence Viewer  
  EDM07977 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000058858
  ENSRNOP00000058858.2
GenBank Protein O35293 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_062176   ⟸   NM_019303
- UniProtKB: O35293 (UniProtKB/Swiss-Prot),   A6J9A7 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000058858   ⟸   ENSRNOT00000068690

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O35293-F1-model_v2 AlphaFold O35293 1-491 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13689841
Promoter ID:EPDNEW_R366
Type:multiple initiation site
Name:Cyp2f4_1
Description:cytochrome P450, family 2, subfamily f, polypeptide 4
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0183,934,024 - 83,934,084EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2476 AgrOrtholog
BioCyc Gene G2FUF-60327 BioCyc
Ensembl Genes ENSRNOG00000032805 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000068690 ENTREZGENE
  ENSRNOT00000068690.4 UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.630.10 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7099393 IMAGE-MGC_LOAD
InterPro Cyt_P450 UniProtKB/Swiss-Prot
  Cyt_P450_CS UniProtKB/Swiss-Prot
  Cyt_P450_CYP2_fam UniProtKB/Swiss-Prot
  Cyt_P450_E_grp-I UniProtKB/Swiss-Prot
  Cyt_P450_sf UniProtKB/Swiss-Prot
  Cytochrome_P450_fam2 UniProtKB/Swiss-Prot
KEGG Report rno:54246 UniProtKB/Swiss-Prot
MGC_CLONE MGC:91721 IMAGE-MGC_LOAD
NCBI Gene 54246 ENTREZGENE
PANTHER CYTOCHROME P450 2F1 UniProtKB/Swiss-Prot
  CYTOCHROME P450 508A4-RELATED UniProtKB/Swiss-Prot
Pfam p450 UniProtKB/Swiss-Prot
PharmGKB CYP2F1 RGD
PhenoGen Cyp2f4 PhenoGen
PRINTS EP450I UniProtKB/Swiss-Prot
  EP450ICYP2F UniProtKB/Swiss-Prot
  P450 UniProtKB/Swiss-Prot
PROSITE CYTOCHROME_P450 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000032805 RatGTEx
Superfamily-SCOP SSF48264 UniProtKB/Swiss-Prot
TIGR TC222327
UniProt A6J9A7 ENTREZGENE, UniProtKB/TrEMBL
  CP2F2_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2007-07-06 Cyp2f4  cytochrome P450, family 2, subfamily f, polypeptide 4  Cyp2f2  cytochrome P450, family 2, subfamily f, polypeptide 2  Name updated 1299863 APPROVED
2004-09-10 Cyp2f2  cytochrome P450, family 2, subfamily f, polypeptide 2  Cyp2f1  cytochrome P450, subfamily 2F, polypeptide 1  Symbol and Name updated 1299863 APPROVED
2002-11-06 Cyp2f1  cytochrome P450, subfamily 2F, polypeptide 1    Cytochrome P450, subfamily IIF, polypeptide 1  Name updated 625702 APPROVED
2002-06-10 Cyp2f1  Cytochrome P450, subfamily IIF, polypeptide 1      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in lung 1300428
gene_function forms styrene glycol from styrene in liver and lung microsomes; rate of metabolism increased in lungs of smokers compared to non-smokers 1300429