Cyp2a2 (cytochrome P450, family 2, subfamily a, polypeptide 2) - Rat Genome Database

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Gene: Cyp2a2 (cytochrome P450, family 2, subfamily a, polypeptide 2) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Cyp2a2
Name: cytochrome P450, family 2, subfamily a, polypeptide 2
RGD ID: 2464
Description: Enables steroid hydroxylase activity. Predicted to be involved in coumarin metabolic process; epoxygenase P450 pathway; and xenobiotic metabolic process. Predicted to be located in endoplasmic reticulum membrane. Predicted to be active in cytoplasm; PARTICIPATES IN caffeine metabolic pathway; phase I biotransformation pathway via cytochrome P450; retinol metabolic pathway; INTERACTS WITH (S)-nicotine; 1-naphthyl isothiocyanate; 2,2',4,4'-Tetrabromodiphenyl ether.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: CYP2A21; CYPIIA2; cytochrome P450 2A2; Cytochrome P450 IIA2; cytochrome P450, subfamily 2A, polypeptide 1; cytochrome P450, subfamily 2A, polypeptide 2; cytochrome P450-UT-4; hepatic steroid hydroxylase IIA2 (CYP2A2); P450-UT-4; RATCYP2A21; testosterone 15-alpha-hydroxylase
RGD Orthologs
Alliance Orthologs
More Info homologs ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8191,391,492 - 91,417,158 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl191,391,502 - 91,417,158 (+)EnsemblGRCr8
mRatBN7.2182,263,833 - 82,289,487 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl182,263,833 - 82,289,487 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx187,681,303 - 87,706,956 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0196,167,559 - 96,185,820 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0189,437,163 - 89,462,814 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0183,744,229 - 83,766,490 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl183,653,234 - 83,766,484 (+)Ensemblrn6Rnor6.0
Rnor_5.0184,957,716 - 84,980,712 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4182,039,229 - 82,064,293 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera176,681,056 - 76,706,240 (+)NCBICelera
RGSC_v3.1182,117,339 - 82,142,404 (+)NCBI
Cytogenetic Map1q21NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Interaction of bisphenol A with rat hepatic cytochrome P450 enzymes. Hanioka N, etal., Chemosphere 2000 Oct;41(7):973-8.
3. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
4. Structure and in vitro transcription of the rat CYP2A1 and CYP2A2 genes and regional localization of the CYP2A gene subfamily on mouse chromosome 7. Matsunaga T, etal., Biochemistry 1990 Feb 6;29(5):1329-41.
5. Gene conversion and differential regulation in the rat P-450 IIA gene subfamily. Purification, catalytic activity, cDNA and deduced amino acid sequence, and regulation of an adult male-specific hepatic testosterone 15 alpha-hydroxylase. Matsunaga T, etal., J Biol Chem 1988 Dec 5;263(34):17995-8002.
6. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
7. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
8. GOA pipeline RGD automated data pipeline
9. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:2434473   PMID:2650624   PMID:12477932   PMID:15539409   PMID:22217848  


Genomics

Variants

.
Variants in Cyp2a2
258 total Variants

QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1578649Bmd8Bone mineral density QTL 84.9femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)151940904101229020Rat
1582234Gluco18Glucose level QTL 183.40.0003blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)187889942132889942Rat
1358359Sradr1Stress Responsive Adrenal Weight QTL 14.74adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)139728272132889942Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)151941022208479811Rat
1358192Ept13Estrogen-induced pituitary tumorigenesis QTL 133.4pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)186622262131622262Rat
6903308Scl36Serum cholesterol QTL 3620.0125blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)158769992103769992Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)151940904168768703Rat
2300164Bmd44Bone mineral density QTL 445.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)166077886111077886Rat
1331800Scl25Serum cholesterol level QTL 253.013blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)187785026142582336Rat
7421628Bp361Blood pressure QTL 3610.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183019780128019780Rat
152025249Scl82Serum cholesterol level QTL 824.77blood cholesterol amount (VT:0000180)152891222109116986Rat
631495Bp96Blood pressure QTL 964.52arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)166404680111404680Rat
10054135Gmadr2Adrenal mass QTL 21.970.0129adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)186993904131993904Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134184556172281316Rat
631512Scl6Serum cholesterol level QTL 69.6blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)18126986099645535Rat
7411712Strs4Sensitivity to stroke QTL 48.7cerebrum integrity trait (VT:0010549)percentage of study population developing cerebrovascular lesions during a period of time (CMO:0000932)187558587132558587Rat
2298545Neuinf8Neuroinflammation QTL 84.6nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)166009857160501508Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134565911208798288Rat
1302788Scl19Serum cholesterol QTL 194.60.001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)166400974132889942Rat
1549903Bp267Blood pressure QTL 267arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)184107164115183752Rat
2313083Bmd74Bone mineral density QTL 7440.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)191302413136302413Rat
2313402Anxrr24Anxiety related response QTL 24aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)151511344153680016Rat
61342Bp27Blood pressure QTL 273.40.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16540563796805205Rat

Markers in Region
D1Mco23  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.0183,743,927 - 83,744,072NCBIRnor6.0
Rnor_5.0184,957,414 - 84,957,559UniSTSRnor5.0
RGSC_v3.4182,038,899 - 82,039,072RGDRGSC3.4
RGSC_v3.4182,038,900 - 82,039,072UniSTSRGSC3.4
Celera176,680,727 - 76,680,899UniSTS
RGSC_v3.1182,117,010 - 82,117,183RGD
Cytogenetic Map1q21UniSTS


Expression

RNA-SEQ Expression

appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 9 38 57 60 41 18 41 99 36 30 14 25 19

Sequence


Ensembl Acc Id: ENSRNOT00000085008   ⟹   ENSRNOP00000075563
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl191,391,502 - 91,417,158 (+)Ensembl
mRatBN7.2 Ensembl182,263,833 - 82,289,487 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000085245   ⟹   ENSRNOP00000071749
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl182,266,306 - 82,289,487 (+)Ensembl
RefSeq Acc Id: NM_012693   ⟹   NP_036825
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8191,391,502 - 91,417,158 (+)NCBI
mRatBN7.2182,263,833 - 82,289,487 (+)NCBI
Rnor_6.0183,744,229 - 83,766,490 (+)NCBI
Rnor_5.0184,957,716 - 84,980,712 (+)NCBI
RGSC_v3.4182,039,229 - 82,064,293 (+)RGD
Celera176,681,056 - 76,706,240 (+)RGD
Sequence:
RefSeq Acc Id: XM_063281066   ⟹   XP_063137136
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8191,391,564 - 91,416,900 (+)NCBI
RefSeq Acc Id: XM_063281067   ⟹   XP_063137137
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8191,391,492 - 91,416,900 (+)NCBI
RefSeq Acc Id: NP_036825   ⟸   NM_012693
- UniProtKB: Q5EBB3 (UniProtKB/Swiss-Prot),   P15149 (UniProtKB/Swiss-Prot),   A6J9A6 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000075563   ⟸   ENSRNOT00000085008
Ensembl Acc Id: ENSRNOP00000071749   ⟸   ENSRNOT00000085245
RefSeq Acc Id: XP_063137137   ⟸   XM_063281067
- Peptide Label: isoform X1
RefSeq Acc Id: XP_063137136   ⟸   XM_063281066
- Peptide Label: isoform X1

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P15149-F1-model_v2 AlphaFold P15149 1-492 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13689848
Promoter ID:EPDNEW_R365
Type:single initiation site
Name:Cyp2a1_2
Description:cytochrome P450, family 2, subfamily a, polypeptide 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R364  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0183,744,213 - 83,744,273EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2464 AgrOrtholog
BioCyc Gene G2FUF-60331 BioCyc
Ensembl Genes ENSRNOG00000020817 Ensembl
  ENSRNOG00000069320 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000085008 ENTREZGENE
  ENSRNOT00000085008.2 UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.630.10 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7371951 IMAGE-MGC_LOAD
InterPro Cyt_P450 UniProtKB/Swiss-Prot
  Cyt_P450_CS UniProtKB/Swiss-Prot
  Cyt_P450_E_grp-I UniProtKB/Swiss-Prot
  Cyt_P450_E_grp-I_CYP2A-like UniProtKB/Swiss-Prot
  Cyt_P450_sf UniProtKB/Swiss-Prot
  Cytochrome_P450_fam2 UniProtKB/Swiss-Prot
KEGG Report rno:24895 UniProtKB/Swiss-Prot
MGC_CLONE MGC:108758 IMAGE-MGC_LOAD
NCBI Gene 24895 ENTREZGENE
PANTHER CYTOCHROME P450 2A13 UniProtKB/Swiss-Prot
  CYTOCHROME P450 508A4-RELATED UniProtKB/Swiss-Prot
Pfam p450 UniProtKB/Swiss-Prot
PhenoGen Cyp2a2 PhenoGen
PRINTS EP450I UniProtKB/Swiss-Prot
  EP450ICYP2A UniProtKB/Swiss-Prot
  P450 UniProtKB/Swiss-Prot
PROSITE CYTOCHROME_P450 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000020817 RatGTEx
  ENSRNOG00000069320 RatGTEx
Superfamily-SCOP SSF48264 UniProtKB/Swiss-Prot
UniProt A0A0G2K193_RAT UniProtKB/TrEMBL
  A6J9A6 ENTREZGENE, UniProtKB/TrEMBL
  CP2A2_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q5EBB3 ENTREZGENE
UniProt Secondary Q5EBB3 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2010-04-19 Cyp2a2  cytochrome P450, subfamily 2A, polypeptide 2  Cyp2a2  cytochrome P450, subfamily 2A, polypeptide 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2010-04-19 Cyp2a2  cytochrome P450, family 2, subfamily a, polypeptide 2  Cyp2a2  cytochrome P450, subfamily 2A, polypeptide 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-11-06 Cyp2a2  cytochrome P450, subfamily 2A, polypeptide 1    Cytochrome P450 IIA2  Name updated 625702 APPROVED
2002-06-10 Cyp2a2  Cytochrome P450 IIA2      Symbol and Name status set to approved 70586 APPROVED