Cyp2a1 (cytochrome P450, family 2, subfamily a, polypeptide 1) - Rat Genome Database

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Gene: Cyp2a1 (cytochrome P450, family 2, subfamily a, polypeptide 1) Rattus norvegicus
Analyze
Symbol: Cyp2a1
Name: cytochrome P450, family 2, subfamily a, polypeptide 1
RGD ID: 2463
Description: Enables steroid hydroxylase activity. Involved in coumarin metabolic process. Predicted to be located in endoplasmic reticulum membrane. Predicted to be active in cytoplasm. Orthologous to human CYP2A13 (cytochrome P450 family 2 subfamily A member 13); PARTICIPATES IN phase I biotransformation pathway via cytochrome P450; vitamin A deficiency pathway; caffeine metabolic pathway; INTERACTS WITH (+)-schisandrin B; (S)-nicotine; 1,3,5-trinitro-1,3,5-triazinane.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: CYPIIA1; cytochrome P450 2A1; cytochrome P450 IIA1 (hepatic steroid hydroxylase IIA1); cytochrome P450 IIA1 (hepatic steroid hydroxylase IIA1) gene; cytochrome P450-UT-F; P450-UT-F; RATCYP2A1; Shdl; Shdl_mapped; steroid hormones 7-alpha-hydroxylase; steroid hydroxylase, hepatic; steroid hydroxylase, hepatic (mapped); testosterone 7-alpha-hydroxylase
RGD Orthologs
Human
Mouse
Dog
Pig
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8191,359,278 - 91,372,554 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl191,359,272 - 91,389,730 (+)EnsemblGRCr8
mRatBN7.2182,231,611 - 82,244,887 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl182,231,611 - 82,244,887 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx187,648,386 - 87,662,372 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0196,134,701 - 96,148,681 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0189,404,242 - 89,418,228 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0183,711,223 - 83,725,222 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl183,653,234 - 83,766,484 (+)Ensemblrn6Rnor6.0
Rnor_5.0184,925,733 - 84,938,423 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4182,006,828 - 82,020,282 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera176,649,089 - 76,662,287 (+)NCBICelera
RGSC_v3.1182,084,938 - 82,098,390 (+)NCBI
Cytogenetic Map1q21NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(1->4)-beta-D-glucan  (ISO)
(S)-nicotine  (EXP,ISO)
1,3,5-trinitro-1,3,5-triazinane  (EXP)
1-benzylpiperazine  (EXP)
1-naphthol  (ISO)
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
2-acetamidofluorene  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3-methylcholanthrene  (EXP)
3-methyleneindolenine  (ISO)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (ISO)
4-oxo-4-(pyridin-3-yl)butanal  (ISO)
5-Hydroxyflavone  (ISO)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (EXP)
6-propyl-2-thiouracil  (EXP)
9-phenanthrol  (ISO)
acenaphthene  (ISO)
acenaphthylene  (ISO)
acetophenones  (ISO)
aflatoxin B1  (ISO)
Aflatoxin G1  (ISO)
alendronic acid  (EXP)
all-trans-retinoic acid  (ISO)
alpha-hexachlorocyclohexane  (EXP)
amiodarone  (EXP)
amitriptyline  (EXP)
ammonium chloride  (EXP)
amodiaquine  (ISO)
Aroclor 1254  (EXP)
benzbromarone  (EXP)
benzene  (EXP)
benzo[a]pyrene  (ISO)
beta-naphthoflavone  (EXP,ISO)
bexarotene  (EXP)
biphenyl  (ISO)
biphenyl-4-amine  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
carbon nanotube  (ISO)
chenodeoxycholic acid  (EXP)
chlorohydrocarbon  (EXP)
cholic acid  (EXP)
chrysin  (ISO)
clofibrate  (EXP)
clomipramine  (EXP)
coumarin  (EXP,ISO)
cyhalothrin  (EXP)
cylindrospermopsin  (ISO)
DDT  (EXP)
deoxycholic acid  (EXP)
dexamethasone  (EXP)
dichloroacetic acid  (ISO)
endosulfan  (ISO)
ethanol  (EXP)
farnesol  (EXP)
fipronil  (EXP)
flavonoids  (EXP)
flutamide  (EXP)
Furafylline  (EXP)
gamma-hexachlorocyclohexane  (EXP)
genistein  (EXP)
glafenine  (EXP)
helenalin  (ISO)
hexamethylphosphoric triamide  (ISO)
imipramine  (EXP)
inulin  (ISO)
ketoconazole  (EXP)
L-ethionine  (EXP)
leflunomide  (EXP)
lipopolysaccharide  (ISO)
lithocholic acid  (EXP)
m-xylene  (EXP)
Metaxalone  (EXP)
methimazole  (EXP)
methoxsalen  (EXP,ISO)
methyl tert-butyl ether  (EXP)
methylisothiazolinone  (ISO)
methylmercury chloride  (EXP)
metyrapone  (ISO)
miconazole  (ISO)
monosodium L-glutamate  (EXP)
N'-Nitrosoanabasine  (ISO)
N'-Nitrosoanatabine  (ISO)
N'-Nitrosonornicotine  (ISO)
N,N-diethyl-m-toluamide  (ISO)
N,N-dimethylaniline  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
N-nitrosodimethylamine  (EXP)
N-Nitrosoguvacoline  (ISO)
N-Nitrosopyrrolidine  (ISO)
NADP zwitterion  (ISO)
NADP(+)  (ISO)
naphthalene  (ISO)
nicotine  (EXP,ISO)
nimesulide  (EXP)
O-methyleugenol  (ISO)
okadaic acid  (ISO)
omeprazole  (EXP)
organoselenium compound  (ISO)
oxycodone  (EXP)
perfluorooctane-1-sulfonic acid  (ISO)
phenanthrene  (ISO)
phenanthrenes  (ISO)
phenobarbital  (EXP,ISO)
pirinixic acid  (EXP)
pregnenolone 16alpha-carbonitrile  (EXP)
pyrrolidine dithiocarbamate  (ISO)
quinomethionate  (ISO)
raloxifene  (EXP)
resveratrol  (ISO)
rifampicin  (EXP,ISO)
semicarbazide  (EXP)
senecionine  (ISO)
skatole  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (EXP)
streptozocin  (EXP,ISO)
tamoxifen  (EXP)
taurocholic acid  (EXP)
testosterone  (EXP)
testosterone enanthate  (EXP)
tetrachloromethane  (EXP)
thioacetamide  (EXP)
toluene  (EXP)
tranylcypromine  (ISO)
trichloroethene  (EXP)
Triptolide  (ISO)
vinclozolin  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
3. Species differences in coumarin metabolism: a molecular modelling evaluation of CYP2A interactions. Lewis DF and Lake BG, Xenobiotica 2002 Jul;32(7):547-61.
4. Structure and in vitro transcription of the rat CYP2A1 and CYP2A2 genes and regional localization of the CYP2A gene subfamily on mouse chromosome 7. Matsunaga T, etal., Biochemistry 1990 Feb 6;29(5):1329-41.
5. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
6. Rat testosterone 7 alpha-hydroxylase. Isolation, sequence, and expression of cDNA and its developmental regulation and induction by 3-methylcholanthrene. Nagata K, etal., J Biol Chem 1987 Feb 25;262(6):2787-93.
7. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
8. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
9. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
10. GOA pipeline RGD automated data pipeline
11. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
12. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
13. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
14. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
Additional References at PubMed
PMID:2650624   PMID:3436956   PMID:22217848  


Genomics

Comparative Map Data
Cyp2a1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8191,359,278 - 91,372,554 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl191,359,272 - 91,389,730 (+)EnsemblGRCr8
mRatBN7.2182,231,611 - 82,244,887 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl182,231,611 - 82,244,887 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx187,648,386 - 87,662,372 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0196,134,701 - 96,148,681 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0189,404,242 - 89,418,228 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0183,711,223 - 83,725,222 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl183,653,234 - 83,766,484 (+)Ensemblrn6Rnor6.0
Rnor_5.0184,925,733 - 84,938,423 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4182,006,828 - 82,020,282 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera176,649,089 - 76,662,287 (+)NCBICelera
RGSC_v3.1182,084,938 - 82,098,390 (+)NCBI
Cytogenetic Map1q21NCBI
CYP2A13
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381941,088,451 - 41,096,195 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1941,088,451 - 41,096,195 (+)Ensemblhg38GRCh38
GRCh371941,594,356 - 41,602,100 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361946,286,208 - 46,293,939 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341946,286,207 - 46,293,939NCBI
Celera1938,394,537 - 38,402,261 (+)NCBICelera
Cytogenetic Map19q13.2NCBI
HuRef1938,026,475 - 38,034,212 (+)NCBIHuRef
CHM1_11941,594,072 - 41,601,816 (+)NCBICHM1_1
T2T-CHM13v2.01943,909,356 - 43,917,084 (+)NCBIT2T-CHM13v2.0
Cyp2a22
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39726,631,564 - 26,638,838 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl726,631,056 - 26,638,809 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38726,931,631 - 26,939,413 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl726,931,631 - 26,939,384 (-)Ensemblmm10GRCm38
MGSCv37727,716,650 - 27,724,405 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36726,640,391 - 26,648,146 (-)NCBIMGSCv36mm8
MGSCv36719,166,984 - 19,174,739 (-)NCBIMGSCv36mm8
Celera721,502,433 - 21,510,189 (-)NCBICelera
Cytogenetic Map7A3NCBI
cM Map715.65NCBI
CYP2A13
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11112,932,246 - 112,938,248 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1112,931,985 - 112,938,350 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1112,334,931 - 112,340,932 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01113,530,545 - 113,536,550 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1113,529,888 - 113,536,652 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11113,090,324 - 113,096,328 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01112,722,239 - 112,728,251 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01113,716,309 - 113,722,322 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
CYP2A19
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl649,056,578 - 49,064,107 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1649,056,579 - 49,064,111 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2644,872,084 - 44,877,470 (+)NCBISscrofa10.2Sscrofa10.2susScr3

Variants

.
Variants in Cyp2a1
180 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:112
Count of miRNA genes:92
Interacting mature miRNAs:97
Transcripts:ENSRNOT00000028237
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1578649Bmd8Bone mineral density QTL 84.9femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)151940904101229020Rat
1582234Gluco18Glucose level QTL 183.40.0003blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)187889942132889942Rat
1358359Sradr1Stress Responsive Adrenal Weight QTL 14.74adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)139728272132889942Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)151941022208479811Rat
1358192Ept13Estrogen-induced pituitary tumorigenesis QTL 133.4pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)186622262131622262Rat
6903308Scl36Serum cholesterol QTL 3620.0125blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)158769992103769992Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)151940904168768703Rat
2300164Bmd44Bone mineral density QTL 445.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)166077886111077886Rat
1331800Scl25Serum cholesterol level QTL 253.013blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)187785026142582336Rat
7421628Bp361Blood pressure QTL 3610.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183019780128019780Rat
152025249Scl82Serum cholesterol level QTL 824.77blood cholesterol amount (VT:0000180)152891222109116986Rat
631495Bp96Blood pressure QTL 964.52arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)166404680111404680Rat
10054135Gmadr2Adrenal mass QTL 21.970.0129adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)186993904131993904Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134184556172281316Rat
631512Scl6Serum cholesterol level QTL 69.6blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)18126986099645535Rat
7411712Strs4Sensitivity to stroke QTL 48.7cerebrum integrity trait (VT:0010549)percentage of study population developing cerebrovascular lesions during a period of time (CMO:0000932)187558587132558587Rat
2298545Neuinf8Neuroinflammation QTL 84.6nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)166009857160501508Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134565911208798288Rat
1302788Scl19Serum cholesterol QTL 194.60.001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)166400974132889942Rat
1549903Bp267Blood pressure QTL 267arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)184107164115183752Rat
2313083Bmd74Bone mineral density QTL 7440.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)191302413136302413Rat
2313402Anxrr24Anxiety related response QTL 24aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)151511344153680016Rat
61342Bp27Blood pressure QTL 273.40.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16540563796805205Rat

Markers in Region
D1Wox16  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8191,302,413 - 91,302,615 (+)Marker Load Pipeline
mRatBN7.2182,174,743 - 82,174,945 (+)MAPPERmRatBN7.2
Rnor_6.0183,656,882 - 83,657,083NCBIRnor6.0
Rnor_5.0184,871,364 - 84,871,565UniSTSRnor5.0
RGSC_v3.4181,947,771 - 81,947,972UniSTSRGSC3.4
RGSC_v3.4181,947,770 - 81,947,972RGDRGSC3.4
Celera176,593,887 - 76,594,088UniSTS
RGSC_v3.1182,025,881 - 82,026,083RGD
RH 3.4 Map1826.1RGD
RH 3.4 Map1826.1UniSTS
RH 2.0 Map1515.9RGD
Cytogenetic Map1q21UniSTS
D1Mco22  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2182,230,245 - 82,230,468 (+)MAPPERmRatBN7.2
Rnor_6.0183,709,886 - 83,710,108NCBIRnor6.0
Rnor_5.0184,924,368 - 84,924,590UniSTSRnor5.0
RGSC_v3.4182,005,462 - 82,005,685RGDRGSC3.4
RGSC_v3.4182,005,463 - 82,005,685UniSTSRGSC3.4
Celera176,647,724 - 76,647,946UniSTS
RGSC_v3.1182,083,573 - 82,083,796RGD
Cytogenetic Map1q21UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
6 9 14 69 91 90 59 23 59 6 152 58 50 21 41 31

Sequence


Ensembl Acc Id: ENSRNOT00000028237   ⟹   ENSRNOP00000028237
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl191,359,272 - 91,372,829 (+)Ensembl
mRatBN7.2 Ensembl182,231,611 - 82,244,887 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000085245   ⟹   ENSRNOP00000071749
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl191,359,272 - 91,389,730 (+)Ensembl
RefSeq Acc Id: NM_012692   ⟹   NP_036824
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8191,359,278 - 91,372,554 (+)NCBI
mRatBN7.2182,231,611 - 82,244,887 (+)NCBI
Rnor_6.0183,711,251 - 83,724,936 (+)NCBI
Rnor_5.0184,925,733 - 84,938,423 (+)NCBI
RGSC_v3.4182,006,828 - 82,020,282 (+)RGD
Celera176,649,089 - 76,662,287 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_036824 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA41020 (Get FASTA)   NCBI Sequence Viewer  
  AAA41030 (Get FASTA)   NCBI Sequence Viewer  
  AAH81848 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000028237
  ENSRNOP00000028237.2
GenBank Protein P11711 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_036824   ⟸   NM_012692
- UniProtKB: Q642C5 (UniProtKB/Swiss-Prot),   P11711 (UniProtKB/Swiss-Prot),   A0A0G2KAX4 (UniProtKB/TrEMBL),   A6J9A5 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000028237   ⟸   ENSRNOT00000028237
Ensembl Acc Id: ENSRNOP00000071749   ⟸   ENSRNOT00000085245

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P11711-F1-model_v2 AlphaFold P11711 1-492 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13689839
Promoter ID:EPDNEW_R364
Type:multiple initiation site
Name:Cyp2a1_1
Description:cytochrome P450, family 2, subfamily a, polypeptide 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R365  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0183,711,245 - 83,711,305EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2463 AgrOrtholog
BioCyc Gene G2FUF-60332 BioCyc
Ensembl Genes ENSRNOG00000020817 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000028237 ENTREZGENE
  ENSRNOT00000028237.5 UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.630.10 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7135880 IMAGE-MGC_LOAD
InterPro Cyt_P450 UniProtKB/Swiss-Prot
  Cyt_P450_CS UniProtKB/Swiss-Prot
  Cyt_P450_E_grp-I UniProtKB/Swiss-Prot
  Cyt_P450_E_grp-I_CYP2A-like UniProtKB/Swiss-Prot
  Cyt_P450_sf UniProtKB/Swiss-Prot
  Cytochrome_P450_fam2 UniProtKB/Swiss-Prot
KEGG Report rno:24894 UniProtKB/Swiss-Prot
MGC_CLONE MGC:93632 IMAGE-MGC_LOAD
NCBI Gene 24894 ENTREZGENE
PANTHER CYTOCHROME P450 2A13 UniProtKB/Swiss-Prot
  CYTOCHROME P450 508A4-RELATED UniProtKB/Swiss-Prot
Pfam p450 UniProtKB/Swiss-Prot
PhenoGen Cyp2a1 PhenoGen
PRINTS EP450I UniProtKB/Swiss-Prot
  EP450ICYP2A UniProtKB/Swiss-Prot
  P450 UniProtKB/Swiss-Prot
PROSITE CYTOCHROME_P450 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000020817 RatGTEx
Superfamily-SCOP SSF48264 UniProtKB/Swiss-Prot
TIGR TC215723
UniProt A0A0G2K193_RAT UniProtKB/TrEMBL
  A0A0G2KAX4 ENTREZGENE, UniProtKB/TrEMBL
  A6J9A5 ENTREZGENE, UniProtKB/TrEMBL
  CP2A1_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q642C5 ENTREZGENE
UniProt Secondary Q642C5 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2010-04-19 Cyp2a1  cytochrome P450, family 2, subfamily a, polypeptide 1  Cyp2a1  cytochrome P450 IIA1 (hepatic steroid hydroxylase IIA1) gene  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2007-09-27 Cyp2j5-ps  cytochrome P450 IIA1 (hepatic steroid hydroxylase IIA1) gene  Cyp2a1  Cytochrome P450 IIA1 (hepatic steroid hydroxylase IIA1) gene  Name updated 1299863 APPROVED
2007-04-26 Cyp2a1  Cytochrome P450 IIA1 (hepatic steroid hydroxylase IIA1) gene  Shdl_mapped  steroid hydroxylase, hepatic (mapped)  Data merged from RGD:3672 737654 APPROVED
2005-11-17 Shdl_mapped  steroid hydroxylase, hepatic (mapped)  Shdl  steroid hydroxylase, hepatic  Symbol and Name updated 1556543 APPROVED
2003-04-09 Shdl  steroid hydroxylase, hepatic    Steroid hydroxylase, hepatic  Name updated 629478 APPROVED
2002-06-10 Cyp2a1  Cytochrome P450 IIA1 (hepatic steroid hydroxylase IIA1) gene      Symbol and Name status set to approved 70586 APPROVED
2002-06-10 Shdl  Steroid hydroxylase, hepatic      Symbol and Name status set to approved 70586 APPROVED