Ctf1 (cardiotrophin 1) - Rat Genome Database

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Gene: Ctf1 (cardiotrophin 1) Rattus norvegicus
Analyze
Symbol: Ctf1
Name: cardiotrophin 1
RGD ID: 2442
Description: Enables cytokine activity and leukemia inhibitory factor receptor binding activity. Involved in leukemia inhibitory factor signaling pathway and nervous system development. Predicted to be located in extracellular space. Predicted to be active in extracellular region. Biomarker of hypertension and hypertrophic cardiomyopathy. Human ortholog(s) of this gene implicated in dilated cardiomyopathy. Orthologous to human CTF1 (cardiotrophin 1); PARTICIPATES IN cytokine mediated signaling pathway; Jak-Stat signaling pathway; INTERACTS WITH (+)-pilocarpine; (+)-schisandrin B; 1,2,4-trimethylbenzene.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: cardiotrophin-1; CT-1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81191,758,512 - 191,771,259 (+)NCBIGRCr8
mRatBN7.21182,328,035 - 182,336,346 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1182,328,090 - 182,333,335 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1190,678,674 - 190,683,883 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01197,864,766 - 197,869,976 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01190,535,271 - 190,540,479 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01199,162,319 - 199,168,296 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1199,163,086 - 199,168,296 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01206,186,511 - 206,191,930 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41187,001,445 - 187,006,655 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11187,151,325 - 187,156,536 (+)NCBI
Celera1179,979,246 - 179,984,456 (+)NCBICelera
Cytogenetic Map1q37NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model



  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Ctf1Ratdilated cardiomyopathy  ISOCTF1 (Homo sapiens)1626410 RGD 
Ctf1Rathypertension  ISOCTF1 (Homo sapiens)1626411protein:increased expression:plasmaRGD 
Ctf1Rathypertension  IEP 69823mRNA:increased expression:cardiac ventricleRGD 
Ctf1Rathypertrophic cardiomyopathy  IEP 401793741mRNA:increased expression:heatt (rat)RGD 
Ctf1RatLeft Ventricular Hypertrophy  ISOCTF1 (Homo sapiens)1626411associated with hypertension and protein:increased expression:plasmaRGD 
Object Symbol
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Reference
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Original Reference(s)
Ctf1Ratbranched-chain keto acid dehydrogenase kinase deficiency  ISOCTF1 (Homo sapiens)8554872ClinVar Annotator: match by term: Branched-chain keto acid dehydrogenase kinase deficiencyClinVarPMID:25741868
Ctf1Ratcardiomyopathy  ISOCTF1 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:24033266 more ...
Ctf1Ratdilated cardiomyopathy  ISOCTF1 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:11058912 more ...
Ctf1Ratdilated cardiomyopathy  ISOCTF1 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:11058912 more ...
Ctf1Ratdilated cardiomyopathy  ISOCTF1 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:11058912 more ...
Ctf1Ratfamilial hypertrophic cardiomyopathy  ISOCTF1 (Homo sapiens)8554872ClinVar Annotator: match by term: Primary familial hypertrophic cardiomyopathyClinVarPMID:11058912 more ...
Ctf1Ratgeneralized epilepsy with febrile seizures plus 9  ISOCTF1 (Homo sapiens)8554872ClinVar Annotator: match by term: Generalized epilepsy with febrile seizures plus and type 9ClinVarPMID:28492532
Ctf1Rathypertrophic cardiomyopathy  ISOCTF1 (Homo sapiens)8554872ClinVar Annotator: match by term: Hypertrophic cardiomyopathyClinVarPMID:24033266 more ...
Object Symbol
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Original Reference(s)
Ctf1RatCardiomegaly  ISOCTF1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:18400235 and PMID:19100119
Ctf1RatHypercholesterolemia  ISOCTF1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:21803294
Ctf1RatHypotension  ISOCTF1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:11304496
Ctf1RatInsulin Resistance  ISOCTF1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:21803294
Ctf1Ratkidney disease  ISOCTF1 (Homo sapiens)11554173CTD Direct Evidence: therapeuticCTDPMID:23335628
Ctf1RatNecrosis  ISOCTF1 (Homo sapiens)11554173CTD Direct Evidence: therapeuticCTDPMID:23335628
Ctf1Ratobesity  ISOCTF1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:21803294
Object Symbol
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Original Reference(s)
Ctf1Ratabdominal obesity-metabolic syndrome  ISSCtf1 (Mus musculus)13592920 MouseDO 
Ctf1Rattype 2 diabetes mellitus  ISSCtf1 (Mus musculus)13592920OMIM:125853 more ...MouseDO 

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Object Symbol
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Reference
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Original Reference(s)
Ctf1Rat(+)-pilocarpine increases expressionEXP 6480464Pilocarpine results in increased expression of CTF1 mRNACTDPMID:10506506
Ctf1Rat(+)-schisandrin B multiple interactionsEXP 6480464schizandrin B inhibits the reaction [Carbon Tetrachloride results in decreased expression of CTF1 mRNA]CTDPMID:31150632
Ctf1Rat1,2,4-trimethylbenzene decreases expressionEXP 6480464pseudocumene results in decreased expression of CTF1 proteinCTDPMID:17337753
Ctf1Rat2,3,7,8-tetrachlorodibenzodioxine increases expressionISOCTF1 (Homo sapiens)6480464Tetrachlorodibenzodioxin results in increased expression of CTF1 mRNACTDPMID:17101203
Ctf1Rat2,3,7,8-tetrachlorodibenzodioxine decreases expressionEXP 6480464Tetrachlorodibenzodioxin results in decreased expression of CTF1 mRNACTDPMID:33387578
Ctf1Rat2,3,7,8-tetrachlorodibenzodioxine affects expressionISOCtf1 (Mus musculus)6480464Tetrachlorodibenzodioxin affects the expression of CTF1 mRNACTDPMID:21570461
Ctf1Rat2-methoxy-17beta-estradiol multiple interactionsISOCtf1 (Mus musculus)64804642-Methoxyestradiol inhibits the reaction [cobaltous chloride results in increased expression of CTF1 protein] and 2-Methoxyestradiol inhibits the reaction [Vitamin K 3 results in increased expression of CTF1 protein]CTDPMID:16507596
Ctf1Rat4-hydroxyphenyl retinamide increases expressionISOCtf1 (Mus musculus)6480464Fenretinide results in increased expression of CTF1 mRNACTDPMID:28973697
Ctf1Rat6-propyl-2-thiouracil increases expressionEXP 6480464Propylthiouracil results in increased expression of CTF1 mRNACTDPMID:24780913
Ctf1Rat6-propyl-2-thiouracil decreases expressionEXP 6480464Propylthiouracil results in decreased expression of CTF1 mRNACTDPMID:30047161
Ctf1Ratactinomycin D multiple interactionsEXP 6480464Dactinomycin promotes the reaction [Spironolactone inhibits the reaction [AGT protein results in increased expression of CTF1 mRNA]] and Dactinomycin promotes the reaction [Valsartan inhibits the reaction [AGT protein results in increased expression of CTF1 mRNA]]CTDPMID:23288202
Ctf1Ratamitrole decreases expressionEXP 6480464Amitrole results in decreased expression of CTF1 mRNACTDPMID:30047161
Ctf1Ratammonium chloride affects expressionEXP 6480464Ammonium Chloride affects the expression of CTF1 mRNACTDPMID:16483693
Ctf1Ratanthra[1,9-cd]pyrazol-6(2H)-one multiple interactionsISOCtf1 (Mus musculus)6480464pyrazolanthrone inhibits the reaction [cobaltous chloride results in increased expression of CTF1 protein] and pyrazolanthrone inhibits the reaction [Vitamin K 3 results in increased expression of CTF1 protein]CTDPMID:16507596
Ctf1Ratapocynin multiple interactionsISOCtf1 (Mus musculus)6480464acetovanillone inhibits the reaction [cobaltous chloride results in increased expression of CTF1 protein] and acetovanillone inhibits the reaction [Vitamin K 3 results in increased expression of CTF1 protein]CTDPMID:16507596
Ctf1Ratarsane affects methylationISOCTF1 (Homo sapiens)6480464Arsenic affects the methylation of CTF1 geneCTDPMID:25304211
Ctf1Ratarsenic atom affects methylationISOCTF1 (Homo sapiens)6480464Arsenic affects the methylation of CTF1 geneCTDPMID:25304211
Ctf1Ratarsenous acid multiple interactionsISOCTF1 (Homo sapiens)6480464Arsenic Trioxide inhibits the reaction [4-aminophenylarsenoxide binds to CTF1 protein]CTDPMID:26598702
Ctf1Ratatrazine decreases expressionEXP 6480464Atrazine results in decreased expression of CTF1 mRNACTDPMID:36841081
Ctf1Ratbenzo[a]pyrene affects methylationISOCTF1 (Homo sapiens)6480464Benzo(a)pyrene affects the methylation of CTF1 promoterCTDPMID:27901495

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Biological Process

  
Object Symbol
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Reference
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Original Reference(s)
Ctf1Ratcell surface receptor signaling pathway via JAK-STAT involved_inIBAMGI:1930088 and PANTHER:PTN0023280631600115GO_REF:0000033GO_CentralGO_REF:0000033
Ctf1Ratimmune response involved_inIEAInterPro:IPR0015811600115GO_REF:0000002InterProGO_REF:0000002
Ctf1Ratleukemia inhibitory factor signaling pathway  IMP 1582264 RGD 
Ctf1Ratnervous system development  IDA 727568 RGD 
Ctf1Ratnervous system development involved_inIBAMGI:105115 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Ctf1Ratneuron development acts_upstream_of_or_withinISOCtf1 (Mus musculus)1624291MGI:88439 more ...RGDPMID:15716414
Ctf1Ratpositive regulation of tyrosine phosphorylation of STAT protein involved_inISOCTF1 (Homo sapiens)1624291 PMID:21912637RGDPMID:21912637
Ctf1Ratsignal transduction involved_inIEAGO:00051251600115GO_REF:0000108GOCGO_REF:0000108

Cellular Component

  
Object Symbol
Species
Term
Qualifier
Evidence
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Reference
Notes
Source
Original Reference(s)
Ctf1Ratextracellular region located_inIEAUniProtKB-KW:KW-09641600115GO_REF:0000043UniProtGO_REF:0000043
Ctf1Ratextracellular region located_inIEAInterPro:IPR0015811600115GO_REF:0000002InterProGO_REF:0000002
Ctf1Ratextracellular region is_active_inIBAPANTHER:PTN002328063 and UniProtKB:Q9UBD91600115GO_REF:0000033GO_CentralGO_REF:0000033
Ctf1Ratextracellular region located_inIEAUniProtKB-SubCell:SL-02431600115GO_REF:0000044UniProtGO_REF:0000044
Ctf1Ratextracellular space located_inIEAUniProtKB-KW:KW-02021600115GO_REF:0000043UniProtGO_REF:0000043

Molecular Function
1 to 9 of 9 rows

  
Object Symbol
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Original Reference(s)
Ctf1Ratcytokine activity  TAS 727670 RGD 
Ctf1Ratcytokine activity  IMP 1582264 RGD 
Ctf1Ratcytokine activity enablesIBAMGI:1930088 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Ctf1Ratcytokine activity enablesIEAInterPro:IPR0015811600115GO_REF:0000002InterProGO_REF:0000002
Ctf1Ratcytokine activity enablesIEAUniProtKB-KW:KW-02021600115GO_REF:0000043UniProtGO_REF:0000043
Ctf1Ratleukemia inhibitory factor receptor binding  IMP 1582264 RGD 
Ctf1Ratprotein binding enablesISOCTF1 (Homo sapiens)1624291UniProtKB:P43360 and PMID:25416956RGDPMID:25416956
Ctf1Ratprotein binding enablesISOCTF1 (Homo sapiens) and UniProtKB:Q16619-21624291UniProtKB:P43360 and PMID:32296183RGDPMID:32296183
Ctf1Ratsignaling receptor binding enablesIEAARBA:ARBA000272391600115GO_REF:0000117UniProtGO_REF:0000117
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Imported Annotations - KEGG (archival)

Object Symbol
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Reference
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Source
Original Reference(s)
Ctf1Ratcytokine mediated signaling pathway  IEA 6907045 KEGGrno:04060
Ctf1RatJak-Stat signaling pathway   IEA 6907045 KEGGrno:04630

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#
Reference Title
Reference Citation
1. The cytoprotective effects of the glycoprotein 130 receptor-coupled cytokine, cardiotrophin-1, require activation of NF-kappa B. Craig R, etal., J Biol Chem 2001 Oct 5;276(40):37621-9.
2. Genetic variants in the promoter (g983G>T) and coding region (A92T) of the human cardiotrophin-1 gene (CTF1) in patients with dilated cardiomyopathy. Erdmann J, etal., Hum Mutat. 2000 Nov;16(5):448.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. cDNA cloning of rat cardiotrophin-1 (CT-1): augmented expression of CT-1 gene in ventricle of genetically hypertensive rats. Ishikawa M, etal., Biochem Biophys Res Commun 1996 Feb 15;219(2):377-81.
5. Is plasma cardiotrophin-1 a marker of hypertensive heart disease? Lopez B, etal., J Hypertens. 2005 Mar;23(3):625-32.
6. Development of cardiac hypertrophy by sunitinib in vivo and in vitro rat cardiomyocytes is influenced by the aryl hydrocarbon receptor signaling pathway. Maayah ZH, etal., Arch Toxicol. 2014 Mar;88(3):725-38. doi: 10.1007/s00204-013-1159-5. Epub 2013 Nov 19.
7. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
8. Comparison of the effects of HGF, BDNF, CT-1, CNTF, and the branchial arches on the growth of embryonic cranial motor neurons. Naeem A, etal., J Neurobiol 2002 May;51(2):101-14.
9. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
10. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
11. Cardiotrophin-1 and urocortin cause protection by the same pathway and hypertrophy via distinct pathways in cardiac myocytes. Railson JE, etal., Cytokine 2002 Mar 7;17(5):243-53.
12. GOA pipeline RGD automated data pipeline
13. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
14. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
15. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
16. Hypertrophic responses to cardiotrophin-1 are not mediated by STAT3, but via a MEK5-ERK5 pathway in cultured cardiomyocytes. Takahashi N, etal., J Mol Cell Cardiol. 2005 Jan;38(1):185-92. Epub 2004 Dec 10.
17. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
1 to 17 of 17 rows
PMID:14674704   PMID:15489334   PMID:15659589   PMID:15716414   PMID:19327894   PMID:20216087   PMID:21279379   PMID:21912637   PMID:21926338   PMID:22733458   PMID:22787135   PMID:23064267  
PMID:23277190  



Ctf1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81191,758,512 - 191,771,259 (+)NCBIGRCr8
mRatBN7.21182,328,035 - 182,336,346 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1182,328,090 - 182,333,335 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1190,678,674 - 190,683,883 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01197,864,766 - 197,869,976 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01190,535,271 - 190,540,479 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01199,162,319 - 199,168,296 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1199,163,086 - 199,168,296 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01206,186,511 - 206,191,930 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41187,001,445 - 187,006,655 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11187,151,325 - 187,156,536 (+)NCBI
Celera1179,979,246 - 179,984,456 (+)NCBICelera
Cytogenetic Map1q37NCBI
CTF1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381630,895,846 - 30,903,560 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1630,896,614 - 30,903,547 (+)EnsemblGRCh38hg38GRCh38
GRCh371630,907,935 - 30,914,881 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361630,815,429 - 30,822,382 (+)NCBINCBI36Build 36hg18NCBI36
Build 341630,815,428 - 30,822,381NCBI
Celera1629,382,737 - 29,389,814 (-)NCBICelera
Cytogenetic Map16p11.2NCBI
HuRef1628,470,690 - 28,477,682 (+)NCBIHuRef
CHM1_11632,225,018 - 32,231,972 (+)NCBICHM1_1
T2T-CHM13v2.01631,283,287 - 31,291,024 (+)NCBIT2T-CHM13v2.0
Ctf1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397127,311,872 - 127,317,360 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl7127,311,908 - 127,317,364 (+)EnsemblGRCm39 Ensembl
GRCm387127,712,676 - 127,718,188 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7127,712,736 - 127,718,192 (+)EnsemblGRCm38mm10GRCm38
MGSCv377134,856,250 - 134,861,699 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv367127,503,884 - 127,509,333 (+)NCBIMGSCv36mm8
Celera7127,551,798 - 127,557,251 (+)NCBICelera
Cytogenetic Map7F3NCBI
cM Map769.69NCBI
Ctf1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049554937,735,996 - 7,737,559 (+)NCBIChiLan1.0ChiLan1.0
CTF1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21834,101,941 - 34,109,044 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11638,903,404 - 38,910,508 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01624,065,866 - 24,072,973 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11631,263,009 - 31,269,439 (+)NCBIpanpan1.1PanPan1.1panPan2
CTF1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1617,299,561 - 17,303,095 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl617,299,561 - 17,303,095 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha618,874,611 - 18,878,145 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0617,427,691 - 17,433,408 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl617,406,389 - 17,433,403 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1617,230,218 - 17,233,760 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0617,149,372 - 17,152,903 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0617,461,913 - 17,465,457 (-)NCBIUU_Cfam_GSD_1.0
Ctf1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024409344125,188,961 - 125,193,420 (-)NCBIHiC_Itri_2
SpeTri2.0NW_00493650113,286,821 - 13,291,280 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CTF1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl317,539,941 - 17,544,396 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1317,539,927 - 17,545,250 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2317,955,024 - 17,960,632 (+)NCBISscrofa10.2Sscrofa10.2susScr3
LOC103231119
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1527,579,175 - 27,586,779 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl527,579,987 - 27,585,759 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660681,878,594 - 1,886,866 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ctf1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462478213,976,308 - 13,979,327 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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Variants in Ctf1
29 total Variants

Predicted Target Of
Summary Value
Count of predictions:105
Count of miRNA genes:83
Interacting mature miRNAs:99
Transcripts:ENSRNOT00000025646
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 82 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
1578778Pur4Proteinuria QTL 43.30.003urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)1150700247252085048Rat
1354646Kidm18Kidney mass QTL 185.7kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1151162512256448636Rat
1578780Cm52Cardiac mass QTL 523.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)181591954219808434Rat
1354652Kidm20Kidney mass QTL 204.3kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1177227632256448636Rat
2302378Insul11Insulin level QTL 113.25blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1144267353251128347Rat
1354653Despr9Despair related QTL 90.00019locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1167909849212909849Rat
1578770Stresp23Stress response QTL 23kidney sympathetic nerve activity (VT:0004050)stimulated renal sympathetic nerve activity to basal renal sympathetic nerve activity ratio (CMO:0001786)1123350408182418476Rat
2293673Bss27Bone structure and strength QTL 2718.630.0001femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)1171629477216629477Rat
2293677Bss41Bone structure and strength QTL 419.380.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra cross-sectional area (CMO:0001689)1171629477216629477Rat
1302787Stl25Serum triglyceride level QTL 252.70.0073blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)1180359209210702199Rat

1 to 10 of 82 rows
RH133519  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21182,332,974 - 182,333,193 (+)MAPPERmRatBN7.2
Rnor_6.01199,167,936 - 199,168,154NCBIRnor6.0
Rnor_5.01206,191,567 - 206,191,785UniSTSRnor5.0
RGSC_v3.41187,006,295 - 187,006,513UniSTSRGSC3.4
Celera1179,984,096 - 179,984,314UniSTS
Cytogenetic Map1q36UniSTS




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31


1 to 16 of 16 rows
RefSeq Transcripts NM_017129 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006230221 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017588854 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017588855 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039103132 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039103137 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063282760 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063282761 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063282762 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063282763 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063282764 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC111812 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC072690 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473956 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  D78591 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000001 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
1 to 16 of 16 rows

Ensembl Acc Id: ENSRNOT00000025646   ⟹   ENSRNOP00000025646
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1182,328,784 - 182,333,335 (+)Ensembl
Rnor_6.0 Ensembl1199,163,086 - 199,168,296 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000103205   ⟹   ENSRNOP00000089496
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1182,328,090 - 182,333,335 (+)Ensembl
RefSeq Acc Id: NM_017129   ⟹   NP_058825
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81191,758,602 - 191,763,812 (+)NCBI
mRatBN7.21182,328,125 - 182,333,335 (+)NCBI
Rnor_6.01199,163,086 - 199,168,296 (+)NCBI
Rnor_5.01206,186,511 - 206,191,930 (+)NCBI
RGSC_v3.41187,001,445 - 187,006,655 (+)RGD
Celera1179,979,246 - 179,984,456 (+)RGD
Sequence:
RefSeq Acc Id: XM_006230221   ⟹   XP_006230283
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81191,758,580 - 191,763,815 (+)NCBI
mRatBN7.21182,328,106 - 182,333,338 (+)NCBI
Rnor_6.01199,162,319 - 199,168,296 (+)NCBI
Rnor_5.01206,186,511 - 206,191,930 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039103132   ⟹   XP_038959060
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81191,758,512 - 191,771,259 (+)NCBI
mRatBN7.21182,328,035 - 182,336,332 (+)NCBI
RefSeq Acc Id: XM_039103137   ⟹   XP_038959065
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81191,758,512 - 191,771,259 (+)NCBI
mRatBN7.21182,328,035 - 182,336,346 (+)NCBI
RefSeq Acc Id: XM_063282760   ⟹   XP_063138830
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81191,758,573 - 191,771,259 (+)NCBI
RefSeq Acc Id: XM_063282761   ⟹   XP_063138831
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81191,758,750 - 191,771,259 (+)NCBI
RefSeq Acc Id: XM_063282762   ⟹   XP_063138832
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81191,758,785 - 191,771,259 (+)NCBI
RefSeq Acc Id: XM_063282763   ⟹   XP_063138833
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81191,758,752 - 191,763,815 (+)NCBI
RefSeq Acc Id: XM_063282764   ⟹   XP_063138834
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81191,758,512 - 191,769,976 (+)NCBI
1 to 5 of 11 rows
1 to 5 of 11 rows
RefSeq Acc Id: NP_058825   ⟸   NM_017129
- UniProtKB: Q63086 (UniProtKB/Swiss-Prot),   A6I9T6 (UniProtKB/TrEMBL),   A0A8L2UK35 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006230283   ⟸   XM_006230221
- Peptide Label: isoform X6
- UniProtKB: A0A8L2UK35 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000025646   ⟸   ENSRNOT00000025646
RefSeq Acc Id: XP_038959065   ⟸   XM_039103137
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038959060   ⟸   XM_039103132
- Peptide Label: isoform X2

Name Modeler Protein Id AA Range Protein Structure
AF-Q63086-F1-model_v2 AlphaFold Q63086 1-203 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13690439
Promoter ID:EPDNEW_R964
Type:initiation region
Name:Ctf1_1
Description:cardiotrophin 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01199,163,109 - 199,163,169EPDNEW


1 to 28 of 28 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-57344 BioCyc
Ensembl Genes ENSRNOG00000018962 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000103205 ENTREZGENE
  ENSRNOT00000135427 ENTREZGENE
  ENSRNOT00000151776 ENTREZGENE
  ENSRNOT00000157444 ENTREZGENE
  ENSRNOT00000157597 ENTREZGENE
  ENSRNOT00000161257 ENTREZGENE
Gene3D-CATH 1.20.1250.10 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7096800 IMAGE-MGC_LOAD
InterPro 4_helix_cytokine-like_core UniProtKB/Swiss-Prot
  Leukemia_IF/oncostatin UniProtKB/Swiss-Prot
  PRF/CT UniProtKB/Swiss-Prot
KEGG Report rno:29201 UniProtKB/Swiss-Prot
MGC_CLONE MGC:91750 IMAGE-MGC_LOAD
NCBI Gene 29201 ENTREZGENE
PANTHER CARDIOTROPHIN-1 UniProtKB/Swiss-Prot
  PTHR21353 UniProtKB/Swiss-Prot
Pfam LIF_OSM UniProtKB/Swiss-Prot
PhenoGen Ctf1 PhenoGen
RatGTEx ENSRNOG00000018962 RatGTEx
Superfamily-SCOP SSF47266 UniProtKB/Swiss-Prot
TIGR TC219295
UniProt A0A8I6ABW6 ENTREZGENE, UniProtKB/TrEMBL
  A0A8L2UK35 ENTREZGENE, UniProtKB/TrEMBL
  A6I9T6 ENTREZGENE, UniProtKB/TrEMBL
  A6I9T7 ENTREZGENE, UniProtKB/TrEMBL
  CTF1_RAT UniProtKB/Swiss-Prot, ENTREZGENE
1 to 28 of 28 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Ctf1  cardiotrophin 1      Name updated 70584 APPROVED

Note Type Note Reference
gene_pathway acts via the signal transducer and activator of transcription 3 (STAT3) pathway 727670
gene_process promotes the outgrowth of embryonic cranial motor neurons 727568
gene_product member of the interleukin-6 family of cytokines 727670