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Gene: Cr1l (complement C3b/C4b receptor 1 like) Rattus norvegicus

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Symbol:

Cr1l (Ensembl: Cd46)

Name:

complement C3b/C4b receptor 1 like (Ensembl:CD46 molecule)

RGD ID:

2399

Description:

Involved in negative regulation of complement activation. Predicted to be located in basolateral plasma membrane and external side of plasma membrane. Predicted to be part of receptor complex. Predicted to be active in extracellular space and plasma membrane. Human ortholog(s) of this gene implicated in malaria. Orthologous to human CR1 (complement C3b/C4b receptor 1 (Knops blood group)) and CR1L (complement C3b/C4b receptor 1 like); PARTICIPATES IN coagulation cascade pathway; complement system pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,6-dinitrotoluene; 2-nitrofluorene.

Type:

protein-coding

RefSeq Status:

REVIEWED

Previously known as:

5I2 antigen; antigen 5I2; complement component (3b/4b) receptor 1-like; complement component receptor 1-like protein; Complement receptor related protein; complement receptor type 1; complement regulatory protein Crry; complement regulatory protein Crry-like; Cr1; Crry; LOC100911729

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	13	109,138,132 - 109,189,068 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	13	109,103,235 - 109,188,869 (-)	Ensembl				GRCr8
mRatBN7.2	13	106,606,952 - 106,660,442 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	13	106,574,858 - 106,660,445 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	13	109,130,564 - 109,177,767 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	13	110,514,391 - 110,561,600 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	13	107,738,850 - 107,786,080 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	13	113,824,886 - 113,872,097 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	13	113,824,892 - 113,872,097 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	13	118,372,894 - 118,420,106 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	13	111,010,296 - 111,057,427 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	13	106,037,024 - 106,083,704 (-)	NCBI		Celera
RGSC_v3.1	13	111,204,343 - 111,251,475 (-)	NCBI
RH 3.4 Map	13	756.5	RGD
Cytogenetic Map	13	q27	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(-)-alpha-phellandrene (ISO)

1,2-dimethylhydrazine (ISO)

2,2',4,4'-Tetrabromodiphenyl ether (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,6-dinitrotoluene (EXP)

2-nitrofluorene (EXP)

4,4'-diaminodiphenylmethane (ISO)

4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one (EXP)

acetamide (EXP)

aconitine (EXP)

acrylamide (EXP)

aflatoxin B1 (EXP,ISO)

all-trans-retinoic acid (ISO)

alpha-phellandrene (ISO)

antirheumatic drug (ISO)

belinostat (ISO)

benzo[a]pyrene (ISO)

bisphenol A (EXP,ISO)

cadmium dichloride (EXP)

clofibrate (ISO)

clofibric acid (EXP)

crocidolite asbestos (ISO)

diclofenac (EXP)

diethylstilbestrol (EXP)

diprotium oxide (EXP)

dorsomorphin (ISO)

endosulfan (EXP,ISO)

entinostat (ISO)

eugenol (EXP)

folic acid (ISO)

gentamycin (EXP)

lipopolysaccharide (ISO)

methapyrilene (EXP)

N-nitrosodimethylamine (EXP)

ozone (ISO)

panobinostat (ISO)

paracetamol (EXP,ISO)

perfluorooctane-1-sulfonic acid (ISO)

perfluorooctanoic acid (ISO)

piperonyl butoxide (EXP)

pirinixic acid (EXP)

rotenone (ISO)

S-(1,2-dichlorovinyl)-L-cysteine (ISO)

SB 431542 (ISO)

sodium arsenate (ISO)

sodium arsenite (EXP)

sulforaphane (ISO)

Testosterone propionate (ISO)

tetrachloromethane (ISO)

thapsigargin (EXP)

trichostatin A (ISO)

valproic acid (ISO)

vitamin E (ISO)

water (EXP)

zinc sulfate (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cellular response to hypoxia (ISO)

complement activation (ISO)

complement activation, classical pathway (IEA)

female pregnancy (IEA)

immune system process (IEA)

in utero embryonic development (ISO)

innate immune response (IEA)

negative regulation of complement activation (IEA,IMP,ISO)

negative regulation of complement activation, classical pathway (IBA)

regulation of complement activation (ISO)

regulation of complement-dependent cytotoxicity (ISO)

T cell mediated immunity (IBA)

Cellular Component

basolateral plasma membrane (ISO)

cell surface (ISO)

external side of plasma membrane (ISO)

extracellular space (IBA)

membrane (IEA)

plasma membrane (IBA)

receptor complex (ISO)

Molecular Function

protein binding (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

coagulation cascade pathway (IEA)

complement system pathway (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	A tumor-expressed inhibitor of the early but not late complement lytic pathway enhances tumor growth in a rat model of human breast cancer.	Caragine TA, etal., Cancer Res 2002 Feb 15;62(4):1110-5.
2.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3.	High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence.	Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
4.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
5.	Electronic Transfer of LocusLink and RefSeq Data	NCBI rat LocusLink and RefSeq merged data July 26, 2002
6.	OMIM Disease Annotation Pipeline	OMIM Disease Annotation Pipeline
7.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
8.	GOA pipeline	RGD automated data pipeline
9.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
10.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:7534798	PMID:7590969	PMID:7919144	PMID:8117286	PMID:8144902	PMID:10642554	PMID:12384431	PMID:12477932	PMID:12767833	PMID:15474557	PMID:15489334	PMID:18947875
PMID:20675597	PMID:21795784	PMID:23382219	PMID:25284781	PMID:34563046

Genomics

Comparative Map Data

Cr1l
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	13	109,138,132 - 109,189,068 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	13	109,103,235 - 109,188,869 (-)	Ensembl				GRCr8
mRatBN7.2	13	106,606,952 - 106,660,442 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	13	106,574,858 - 106,660,445 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	13	109,130,564 - 109,177,767 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	13	110,514,391 - 110,561,600 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	13	107,738,850 - 107,786,080 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	13	113,824,886 - 113,872,097 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	13	113,824,892 - 113,872,097 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	13	118,372,894 - 118,420,106 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	13	111,010,296 - 111,057,427 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	13	106,037,024 - 106,083,704 (-)	NCBI		Celera
RGSC_v3.1	13	111,204,343 - 111,251,475 (-)	NCBI
RH 3.4 Map	13	756.5	RGD
Cytogenetic Map	13	q27	NCBI

CR1L
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	1	207,645,133 - 207,723,703 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	1	207,645,113 - 207,738,416 (+)	Ensembl			hg38	GRCh38
GRCh37	1	207,818,478 - 207,897,048 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	1	205,885,081 - 205,963,659 (+)	NCBI	Build 36	Build 36	hg18	NCBI36
Celera	1	181,048,945 - 181,127,502 (+)	NCBI		Celera
Cytogenetic Map	1	q32.2	NCBI
HuRef	1	178,492,781 - 178,571,327 (+)	NCBI		HuRef
CHM1_1	1	209,090,815 - 209,169,432 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	1	206,891,887 - 206,970,453 (+)	NCBI		T2T-CHM13v2.0

Cr1l
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	1	194,781,019 - 194,813,878 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	1	194,779,690 - 194,813,894 (-)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	1	195,098,711 - 195,131,570 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	1	195,097,382 - 195,131,586 (-)	Ensembl			mm10	GRCm38
MGSCv37	1	196,929,982 - 196,957,764 (-)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	1	196,804,512 - 196,832,294 (-)	NCBI		MGSCv36	mm8
Celera	1	202,002,943 - 202,030,729 (-)	NCBI		Celera
Cytogenetic Map	1	H6	NCBI
cM Map	1	98.43	NCBI

CR1L
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	1	41,659,700 - 41,753,664 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	1	41,624,440 - 41,719,720 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	1	183,224,415 - 183,303,268 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	1	188,031,758 - 188,109,742 (+)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	1	188,031,758 - 188,182,046 (+)	Ensembl			panPan2	panpan1.1

CR1L
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	25	21,713,661 - 21,780,968 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
Vero_WHO_p1.0	NW_023666055	22,317,471 - 22,392,380 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	11
Count of miRNA genes:	11
Interacting mature miRNAs:	11
Transcripts:	ENSRNOT00000010799
Prediction methods:	Miranda, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
7207885	Glom27	Glomerulus QTL 27	3.9		kidney glomerulus integrity trait (VT:0010546)	kidney crescentic glomeruli count to kidney normal glomeruli count ratio (CMO:0002139)	13	21120177	109350286	Rat
738027	Lnnr6	Liver neoplastic nodule remodeling QTL 6	3.3		liver integrity trait (VT:0010547)	liver remodeling tumorous lesion number (CMO:0001461)	13	65613454	109350286	Rat
7387280	Uae43	Urinary albumin excretion QTL 43	5.69	0.4174	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	13	68983334	109350286	Rat
2293702	Bss34	Bone structure and strength QTL 34	4.61	0.0001	femur strength trait (VT:0010010)	femur midshaft polar moment of inertia (CMO:0001669)	13	67635937	109350286	Rat
2293687	Bss26	Bone structure and strength QTL 26	4.6	0.0001	femur morphology trait (VT:0000559)	femur cross-sectional area (CMO:0001661)	13	67635937	109350286	Rat
1576318	Schws5	Schwannoma susceptibility QTL 5		0.0351	nervous system integrity trait (VT:0010566)	post-insult time to trigeminal nerve neurilemmoma formation (CMO:0002019)	13	64497900	109350286	Rat
12879475	Bp400	Blood pressure QTL 400			arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	13	64375743	109350286	Rat
8655951	Rf63	Renal function QTL 63	12.2		blood urea nitrogen amount (VT:0005265)	plasma urea nitrogen level (CMO:0000586)	13	71610804	109350286	Rat
4889606	Gluco63	Glucose level QTL 63	2.86	0.003	blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	13	83286150	109350286	Rat
2293341	Glom15	Glomerulus QTL 15	9.1		kidney glomerulus integrity trait (VT:0010546)	kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)	13	67635937	109350286	Rat

Markers in Region

RH94665

Rat Assembly	Chr	Position (strand)	Source	JBrowse
RH 3.4 Map	13	756.5	UniSTS
Cytogenetic Map	13	q27	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
16	12	67	165	91	90	59	92	59	6	356	192	11	144	81	92	31	17	17

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001005265	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_001005330	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_019301	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039091019	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039091020	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039091021	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063272557	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063272558	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC111927	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC061736	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CB707374	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CB775511	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473985	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	D42114	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	D42115	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	D42116	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	D66878	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ220559	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000013	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	L19118	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	L36532	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000010799 ⟹ ENSRNOP00000010798

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	13	109,141,668 - 109,188,869 (-)	Ensembl
mRatBN7.2 Ensembl	13	106,613,186 - 106,660,445 (-)	Ensembl
Rnor_6.0 Ensembl	13	113,824,892 - 113,872,097 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000057151 ⟹ ENSRNOP00000053980

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	13	106,582,007 - 106,606,310 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000079549 ⟹ ENSRNOP00000074390

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	13	109,138,169 - 109,188,869 (-)	Ensembl
mRatBN7.2 Ensembl	13	106,609,677 - 106,660,194 (-)	Ensembl
Rnor_6.0 Ensembl	13	113,825,045 - 113,871,842 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000084320 ⟹ ENSRNOP00000072622

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	13	109,130,746 - 109,188,869 (-)	Ensembl
mRatBN7.2 Ensembl	13	106,613,274 - 106,660,218 (-)	Ensembl
Rnor_6.0 Ensembl	13	113,824,892 - 113,872,097 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000099211 ⟹ ENSRNOP00000082131

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	13	109,130,746 - 109,188,869 (-)	Ensembl
mRatBN7.2 Ensembl	13	106,616,085 - 106,660,441 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000100405 ⟹ ENSRNOP00000091054

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	13	109,104,123 - 109,188,869 (-)	Ensembl
mRatBN7.2 Ensembl	13	106,601,479 - 106,660,194 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000107463 ⟹ ENSRNOP00000080824

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	13	109,103,235 - 109,188,869 (-)	Ensembl
mRatBN7.2 Ensembl	13	106,574,858 - 106,606,310 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000113067 ⟹ ENSRNOP00000079381

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	13	106,574,858 - 106,606,310 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000118720 ⟹ ENSRNOP00000076787

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	13	109,134,638 - 109,188,869 (-)	Ensembl
mRatBN7.2 Ensembl	13	106,620,707 - 106,660,414 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000120085 ⟹ ENSRNOP00000097736

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	13	109,140,820 - 109,188,869 (-)	Ensembl
mRatBN7.2 Ensembl	13	106,613,264 - 106,660,414 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000165602 ⟹ ENSRNOP00000101783

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	13	109,143,737 - 109,188,869 (-)	Ensembl

RefSeq Acc Id:

NM_001005265 ⟹ NP_001005265

RefSeq Status:

REVIEWED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	13	109,141,662 - 109,188,869 (-)	NCBI
mRatBN7.2	13	106,613,203 - 106,660,414 (-)	NCBI
Rnor_6.0	13	113,824,886 - 113,872,097 (-)	NCBI
Rnor_5.0	13	118,372,894 - 118,420,106 (-)	NCBI
RGSC_v3.4	13	111,010,296 - 111,057,427 (-)	RGD
Celera	13	106,037,024 - 106,083,704 (-)	RGD

Sequence:

show sequence

GGTGCTTACAAATGGAAAACTTCCAACAGCTGACTTACTATGGATTGATCCAGTGCTTGCGTTG
GTGAATCAATCTCCCGAGGAAAATTCCACAGAAATTCCAGGAGCTTGGAGTAAACAAGACCCCG
CCCAGCCCAGGAGGAAGCTGTAGTTCGAGCTTCATTCCGGAACCCAGCGCCATTTCCCGTACTC
TGGGTGGGGCCGCCTCCTCCACCGCTTTGCCGTGAGACTGGGCTTGAGACCGCTGTGAGGGGAA
TGGAGGCTTCTTCGCCTCTGGACCCCGTGGGGCGCCTTGTAGCCTTCTGCCGCGGAGGAGTGCA
TCTGGCCGTCCTGCTGCTGTTCTTGTCGCCATCTACTTTGGGCCAGTGCCCAGCCCCACCACTG
TTTCCTTATGCCAAACCTATAAATCCAACTGATGAATCCACGTTTCCCGTTGGAACATCTTTGA
AGTATGAATGTCGTCCAGGATATATCAAGAGGCAGTTCTCTATCACCTGCGAAGTAAACTCAGT
GTGGACAAGTCCTCAAGACGTGTGTATACGTAAACAATGTGAAACTCCTTTAGATCCTCAGAAT
GGCATAGTACATGTAAACACAGACATCCGGTTTGGATCCTCTATCACTTATACCTGTAATGAAG
GATACCGCCTCATTGGTTCCTCCTCTGCTATGTGCATAATCTCTGATCAGAGCGTTGCCTGGGA
TGCCGAGGCACCTATTTGTGAATCAATTCCTTGTGAGATACCCCCAAGCATTCCCAATGGAGAT
TTCTTCAGTCCTAACAGAGAAGATTTTCATTATGGAATGGTAGTTACCTACCAGTGCAACACTG
ATGCGAGAGGGAAGAAGCTCTTTAACCTGGTGGGTGAGCCCTCCATACACTGTACCAGCATCGA
TGGTCAAGTTGGAGTCTGGAGTGGCCCTCCTCCTCAGTGCATTGAACTCAACAAATGTACTCCT
CCCCATGTTGAAAATGCAGTCATAGTGTCTAAAAACAAAAGCTTGTTTTCCTTAAGGGATATGG
TGGAGTTTAGATGTCAGGATGGCTTTATGATGAAAGGAGACAGCAGTGTGTATTGTCGATCCCT
AAACAGATGGGAGCCTCAGTTACCAAGCTGCTTCAAGGTGAAATCCTGTGGTGCTTTCCTGGGT
GAGCTTCCTAATGGGCATGTATTCGTTCCACAAAATCTTCAACTCGGGGCCAAAGTGACCTTTG
TTTGTAATACAGGGTATCAATTAAAAGGCAATTCTTCTAGTCATTGTGTTCTTGATGGAGTGGA
AAGCATTTGGAATAGCAGCGTTCCTGTGTGTGAACAAGTGATATGTAAACTCCCTCAGGATATG
AGTGGATTCCAGAAAGGGTTGCAAATGAAAAAAGATTATTACTATGGAGATAATGTAGCCTTGG
AATGTGAGGATGGGTATACTCTAGAAGGCAGTTCTCAGAGCCAGTGCCAGTCCGATGCCAGCTG
GGATCCTCCTCTGCCCAAATGTGTCTCTCGCTCAAACAGTGGTCTAATAGCTGGAATTTTCATT
GGGATAATCGTCCTTATTTTATTCATCATTTTTTCCTACTGGATGATTATGAAGTTTAAAAAAC
GCAATTCCACCAATGAAAAGTGTAAAGAAGTGGGTATCTATTTAAATTCTAAAGAAGACAGCTG
TGTTCAGCCTCAGTCTCTGCTCACAAGTCAGGAGAACAACAGTACCAGTAGCCCAGCACGGAAT
TCACTCACTCAAGAAGTCTAATAGCCGCCATGTACAGTGATGTCTCTGAAACGCAAAACATTTC
CTGTCTGTATCACTTTTAAAATAAACTATTTTCTTTTAAAATCTAGATGTGTTGTTCATACATA
AGGAATGCAACAAACTCATGGCCACTCAGGATATTTAACTTGTTTCAAAAAT

hide sequence

RefSeq Acc Id:

NM_019301 ⟹ NP_062174

RefSeq Status:

REVIEWED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	13	109,141,662 - 109,188,869 (-)	NCBI
mRatBN7.2	13	106,613,203 - 106,660,414 (-)	NCBI
Rnor_6.0	13	113,824,886 - 113,872,097 (-)	NCBI
Rnor_5.0	13	118,372,894 - 118,420,106 (-)	NCBI
RGSC_v3.4	13	111,010,296 - 111,057,427 (-)	RGD
Celera	13	106,037,024 - 106,083,704 (-)	RGD

Sequence:

show sequence

GGTGCTTACAAATGGAAAACTTCCAACAGCTGACTTACTATGGATTGATCCAGTGCTTGCGTTG
GTGAATCAATCTCCCGAGGAAAATTCCACAGAAATTCCAGGAGCTTGGAGTAAACAAGACCCCG
CCCAGCCCAGGAGGAAGCTGTAGTTCGAGCTTCATTCCGGAACCCAGCGCCATTTCCCGTACTC
TGGGTGGGGCCGCCTCCTCCACCGCTTTGCCGTGAGACTGGGCTTGAGACCGCTGTGAGGGGAA
TGGAGGCTTCTTCGCCTCTGGACCCCGTGGGGCGCCTTGTAGCCTTCTGCCGCGGAGGAGTGCA
TCTGGCCGTCCTGCTGCTGTTCTTGTCGCCATCTACTTTGGGCCAGTGCCCAGCCCCACCACTG
TTTCCTTATGCCAAACCTATAAATCCAACTGATGAATCCACGTTTCCCGTTGGAACATCTTTGA
AGTATGAATGTCGTCCAGGATATATCAAGAGGCAGTTCTCTATCACCTGCGAAGTAAACTCAGT
GTGGACAAGTCCTCAAGACGTGTGTATACGTAAACAATGTGAAACTCCTTTAGATCCTCAGAAT
GGCATAGTACATGTAAACACAGACATCCGGTTTGGATCCTCTATCACTTATACCTGTAATGAAG
GATACCGCCTCATTGGTTCCTCCTCTGCTATGTGCATAATCTCTGATCAGAGCGTTGCCTGGGA
TGCCGAGGCACCTATTTGTGAATCAATTCCTTGTGAGATACCCCCAAGCATTCCCAATGGAGAT
TTCTTCAGTCCTAACAGAGAAGATTTTCATTATGGAATGGTAGTTACCTACCAGTGCAACACTG
ATGCGAGAGGGAAGAAGCTCTTTAACCTGGTGGGTGAGCCCTCCATACACTGTACCAGCATCGA
TGGTCAAGTTGGAGTCTGGAGTGGCCCTCCTCCTCAGTGCATTGAACTCAACAAATGTACTCCT
CCCCATGTTGAAAATGCAGTCATAGTGTCTAAAAACAAAAGCTTGTTTTCCTTAAGGGATATGG
TGGAGTTTAGATGTCAGGATGGCTTTATGATGAAAGGAGACAGCAGTGTGTATTGTCGATCCCT
AAACAGATGGGAGCCTCAGTTACCAAGCTGCTTCAAGGTGAAATCCTGTGGTGCTTTCCTGGGT
GAGCTTCCTAATGGGCATGTATTCGTTCCACAAAATCTTCAACTCGGGGCCAAAGTGACCTTTG
TTTGTAATACAGGGTATCAATTAAAAGGCAATTCTTCTAGTCATTGTGTTCTTGATGGAGTGGA
AAGCATTTGGAATAGCAGCGTTCCTGTGTGTGAACAAGTGATATGTAAACTCCCTCAGGATATG
AGTGGATTCCAGAAAGGGTTGCAAATGAAAAAAGATTATTACTATGGAGATAATGTAGCCTTGG
AATGTGAGGATGGGTATACTCTAGAAGGCAGTTCTCAGAGCCAGTGCCAGTCCGATGCCAGCTG
GGATCCTCCTCTGCCCAAATGTGTCTCTCAAGTGATATGTAAACTCCCTCAGGATATGAGTGGA
TTCCAGAAAGGGTTGCAAATGAAAAAAGATTATTACTATGGAGATAATGTAGCCTTGGAATGTG
AGGATGGGTATACTCTAGAAGGCAGTTCTCAGAGCCAGTGCCAGTCCGATGCCAGCTGGGATCC
TCCTCTGCCCAAATGTGTCTCTCGCTCAAACAGTGGTCTAATAGCTGGAATTTTCATTGGGATA
ATCGTCCTTATTTTATTCATCATTTTTTCCTACTGGATGATTATGAAGTTTAAAAAACGCAATT
CCACCAATGAAAAGTGTAAAGAAGTGGGTATCTATTTAAATTCTAAAGAAGACAGCTGTGTTCA
GCCTCAGTCTCTGCTCACAAGTCAGGAGAACAACAGTACCAGTAGCCCAGCACGGAATTCACTC
ACTCAAGAAGTCTAATAGCCGCCATGTACAGTGATGTCTCTGAAACGCAAAACATTTCCTGTCT
GTATCACTTTTAAAATAAACTATTTTCTTTTAAAATCTAGATGTGTTGTTCATACATAAGGAAT
GCAACAAACTCATGGCCACTCAGGATATTTAACTTGTTTCAAAAAT

hide sequence

RefSeq Acc Id:

XM_039091019 ⟹ XP_038946947

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	13	109,141,737 - 109,189,068 (-)	NCBI
mRatBN7.2	13	106,613,274 - 106,660,440 (-)	NCBI

RefSeq Acc Id:

XM_039091020 ⟹ XP_038946948

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	13	109,138,132 - 109,189,068 (-)	NCBI
mRatBN7.2	13	106,606,952 - 106,660,440 (-)	NCBI

RefSeq Acc Id:

XM_039091021 ⟹ XP_038946949

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	13	109,141,737 - 109,189,068 (-)	NCBI
mRatBN7.2	13	106,613,188 - 106,660,440 (-)	NCBI

RefSeq Acc Id:

XM_063272557 ⟹ XP_063128627

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	13	109,141,737 - 109,189,068 (-)	NCBI

RefSeq Acc Id:

XM_063272558 ⟹ XP_063128628

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	13	109,141,737 - 109,189,068 (-)	NCBI

Protein Sequences


Protein RefSeqs	NP_001005265	(Get FASTA)	NCBI Sequence Viewer
	NP_062174	(Get FASTA)	NCBI Sequence Viewer
	XP_038946947	(Get FASTA)	NCBI Sequence Viewer
	XP_038946948	(Get FASTA)	NCBI Sequence Viewer
	XP_038946949	(Get FASTA)	NCBI Sequence Viewer
	XP_063128627	(Get FASTA)	NCBI Sequence Viewer
	XP_063128628	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAA62424	(Get FASTA)	NCBI Sequence Viewer
	AAA91821	(Get FASTA)	NCBI Sequence Viewer
	AAH61736	(Get FASTA)	NCBI Sequence Viewer
	BAA07698	(Get FASTA)	NCBI Sequence Viewer
	BAA22548	(Get FASTA)	NCBI Sequence Viewer
	BAA22549	(Get FASTA)	NCBI Sequence Viewer
	BAA86960	(Get FASTA)	NCBI Sequence Viewer
	EDL95053	(Get FASTA)	NCBI Sequence Viewer
	EDL95054	(Get FASTA)	NCBI Sequence Viewer
	EDL95055	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000010798
	ENSRNOP00000074390
	ENSRNOP00000097736
	ENSRNOP00000101783
GenBank Protein	Q63135	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:	NP_001005265 ⟸ NM_001005265
- Peptide Label:	isoform 3 precursor
- UniProtKB:	A0A8L2UIA6 (UniProtKB/TrEMBL)
- Sequence:	show sequence MEASSPLDPVGRLVAFCRGGVHLAVLLLFLSPSTLGQCPAPPLFPYAKPINPTDESTFPVGTSL KYECRPGYIKRQFSITCEVNSVWTSPQDVCIRKQCETPLDPQNGIVHVNTDIRFGSSITYTCNE GYRLIGSSSAMCIISDQSVAWDAEAPICESIPCEIPPSIPNGDFFSPNREDFHYGMVVTYQCNT DARGKKLFNLVGEPSIHCTSIDGQVGVWSGPPPQCIELNKCTPPHVENAVIVSKNKSLFSLRDM VEFRCQDGFMMKGDSSVYCRSLNRWEPQLPSCFKVKSCGAFLGELPNGHVFVPQNLQLGAKVTF VCNTGYQLKGNSSSHCVLDGVESIWNSSVPVCEQVICKLPQDMSGFQKGLQMKKDYYYGDNVAL ECEDGYTLEGSSQSQCQSDASWDPPLPKCVSRSNSGLIAGIFIGIIVLILFIIFSYWMIMKFKK RNSTNEKCKEVGIYLNSKEDSCVQPQSLLTSQENNSTSSPARNSLTQEV hide sequence

RefSeq Acc Id:	NP_062174 ⟸ NM_019301
- Peptide Label:	isoform 2 precursor
- UniProtKB:	Q63612 (UniProtKB/Swiss-Prot), Q63135 (UniProtKB/Swiss-Prot), A0A8I6AC67 (UniProtKB/TrEMBL)
- Sequence:	show sequence MEASSPLDPVGRLVAFCRGGVHLAVLLLFLSPSTLGQCPAPPLFPYAKPINPTDESTFPVGTSL KYECRPGYIKRQFSITCEVNSVWTSPQDVCIRKQCETPLDPQNGIVHVNTDIRFGSSITYTCNE GYRLIGSSSAMCIISDQSVAWDAEAPICESIPCEIPPSIPNGDFFSPNREDFHYGMVVTYQCNT DARGKKLFNLVGEPSIHCTSIDGQVGVWSGPPPQCIELNKCTPPHVENAVIVSKNKSLFSLRDM VEFRCQDGFMMKGDSSVYCRSLNRWEPQLPSCFKVKSCGAFLGELPNGHVFVPQNLQLGAKVTF VCNTGYQLKGNSSSHCVLDGVESIWNSSVPVCEQVICKLPQDMSGFQKGLQMKKDYYYGDNVAL ECEDGYTLEGSSQSQCQSDASWDPPLPKCVSQVICKLPQDMSGFQKGLQMKKDYYYGDNVALEC EDGYTLEGSSQSQCQSDASWDPPLPKCVSRSNSGLIAGIFIGIIVLILFIIFSYWMIMKFKKRN STNEKCKEVGIYLNSKEDSCVQPQSLLTSQENNSTSSPARNSLTQEV hide sequence

Ensembl Acc Id:

ENSRNOP00000074390 ⟸ ENSRNOT00000079549

Ensembl Acc Id:

ENSRNOP00000010798 ⟸ ENSRNOT00000010799

Ensembl Acc Id:

ENSRNOP00000072622 ⟸ ENSRNOT00000084320

RefSeq Acc Id:	XP_038946948 ⟸ XM_039091020
- Peptide Label:	isoform X3
- UniProtKB:	A0A0G2K7Y0 (UniProtKB/TrEMBL), A0A8I6AC67 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038946949 ⟸ XM_039091021
- Peptide Label:	isoform X5
- UniProtKB:	A0A8L2UIA6 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038946947 ⟸ XM_039091019
- Peptide Label:	isoform X2
- UniProtKB:	A0A8L2R7U2 (UniProtKB/TrEMBL), A0A8I6AC67 (UniProtKB/TrEMBL)

Ensembl Acc Id:

ENSRNOP00000076787 ⟸ ENSRNOT00000118720

Ensembl Acc Id:

ENSRNOP00000080824 ⟸ ENSRNOT00000107463

Ensembl Acc Id:

ENSRNOP00000097736 ⟸ ENSRNOT00000120085

Ensembl Acc Id:

ENSRNOP00000053980 ⟸ ENSRNOT00000057151

Ensembl Acc Id:

ENSRNOP00000082131 ⟸ ENSRNOT00000099211

Ensembl Acc Id:

ENSRNOP00000079381 ⟸ ENSRNOT00000113067

Ensembl Acc Id:

ENSRNOP00000091054 ⟸ ENSRNOT00000100405

RefSeq Acc Id:	XP_063128628 ⟸ XM_063272558
- Peptide Label:	isoform X4
- UniProtKB:	A0A8I5ZT27 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_063128627 ⟸ XM_063272557
- Peptide Label:	isoform X1
- UniProtKB:	A0A8I5ZT27 (UniProtKB/TrEMBL)

Ensembl Acc Id:

ENSRNOP00000101783 ⟸ ENSRNOT00000165602

Protein Domains

Sushi

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q63135-F1-model_v2	AlphaFold	Q63135	1-559	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13699138

Promoter ID:

EPDNEW_R9658

Type:

initiation region

Name:

Cr1l_1

Description:

complement C3b/C4b receptor 1 like

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	13	113,871,909 - 113,871,969	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:2399	AgrOrtholog
BioCyc Gene	G2FUF-16731	BioCyc
Ensembl Genes	ENSRNOG00000008193	Ensembl, ENTREZGENE
Ensembl Transcript	ENSRNOT00000010799	ENTREZGENE
	ENSRNOT00000079549	ENTREZGENE
	ENSRNOT00000120085	ENTREZGENE
	ENSRNOT00000165602	ENTREZGENE
Gene3D-CATH	Complement Module, domain 1	UniProtKB/Swiss-Prot
IMAGE_CLONE	IMAGE:5599318	IMAGE-MGC_LOAD
InterPro	SEZ6_CSMD_C4BPB_Regulators	UniProtKB/Swiss-Prot
	Sushi/SCR/CCP_sf	UniProtKB/Swiss-Prot
	Sushi_SCR_CCP_dom	UniProtKB/Swiss-Prot
KEGG Report	rno:54243	UniProtKB/Swiss-Prot
MGC_CLONE	MGC:72484	IMAGE-MGC_LOAD
NCBI Gene	54243	ENTREZGENE
PANTHER	CUB AND SUSHI DOMAIN-CONTAINING PROTEIN 1	UniProtKB/Swiss-Prot
	PROTEIN CBR-CLEC-78	UniProtKB/Swiss-Prot
Pfam	Sushi	UniProtKB/Swiss-Prot
PhenoGen	Cr1l	PhenoGen
PROSITE	SUSHI	UniProtKB/Swiss-Prot
RatGTEx	ENSRNOG00000008193	RatGTEx
SMART	CCP	UniProtKB/Swiss-Prot
Superfamily-SCOP	SSF57535	UniProtKB/Swiss-Prot
UniProt	A0A0G2K7Y0	ENTREZGENE, UniProtKB/TrEMBL
	A0A8I5Y5K8_RAT	UniProtKB/TrEMBL
	A0A8I5ZT27	ENTREZGENE, UniProtKB/TrEMBL
	A0A8I6AC67	ENTREZGENE, UniProtKB/TrEMBL
	A0A8I6GMN2_RAT	UniProtKB/TrEMBL
	A0A8L2R7U2	ENTREZGENE, UniProtKB/TrEMBL
	A0A8L2UIA6	ENTREZGENE, UniProtKB/TrEMBL
	A0ABK0LJQ4_RAT	UniProtKB/TrEMBL
	CR1L_RAT	UniProtKB/Swiss-Prot
	O35520_RAT	UniProtKB/TrEMBL
	Q63135	ENTREZGENE
	Q63612	ENTREZGENE
UniProt Secondary	Q63612	UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2016-08-18	Cr1l	complement C3b/C4b receptor 1 like	Cr1l	complement component (3b/4b) receptor 1-like	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2015-07-29	Cr1l	complement component (3b/4b) receptor 1-like	LOC100911729	complement regulatory protein Crry-like	Data merged from RGD:6491360	737654	PROVISIONAL
2012-07-05	LOC100911729	complement regulatory protein Crry-like			Symbol and Name status set to provisional	70820	PROVISIONAL
2008-03-10	Cr1l	complement component (3b/4b) receptor 1-like	Crry	complement receptor related protein	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2002-11-06	Crry	complement receptor related protein	Cr1	Complement receptor related protein	Symbol and Name updated	625702	APPROVED
2002-06-10	Cr1	Complement receptor related protein			Symbol and Name status set to approved	70586	APPROVED

RGD Curation Notes

Note Type	Note	Reference
gene_process	inhibits the in vivo deposition of complement C3 fragments that serve as opsonins for receptors on phagocytes and natural killer cells	625470
gene_process	membrane-bound inhibitor of complement activation	625470
gene_process	membrane-bound inhibitor of complement activation	1298792
gene_process	inhibits cell-mediated cytotoxicity in vitro and enhances the tumorigenicity of MCF7 cells	625470
gene_process	may play a role in tumor immune surveillance	1298793
gene_transcript	two forms are expressed in all tissues; one full length and the other with a duplication of a 186 base pair short consensus repeat	1298791

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Annotations - KEGG (archival)