Bckdhb (branched chain keto acid dehydrogenase E1 subunit beta) - Rat Genome Database

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Gene: Bckdhb (branched chain keto acid dehydrogenase E1 subunit beta) Rattus norvegicus
Analyze
Symbol: Bckdhb
Name: branched chain keto acid dehydrogenase E1 subunit beta
RGD ID: 2197
Description: Predicted to enable metal ion binding activity. Predicted to contribute to 3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring) activity. Involved in response to cAMP; response to glucocorticoid; and response to nutrient. Predicted to be located in mitochondrion; nucleolus; and nucleoplasm. Predicted to be part of mitochondrial alpha-ketoglutarate dehydrogenase complex. Human ortholog(s) of this gene implicated in maple syrup urine disease. Orthologous to human BCKDHB (branched chain keto acid dehydrogenase E1 subunit beta); PARTICIPATES IN 3-hydroxy-3-methylglutaryl-CoA lyase deficiency pathway; 3-hydroxyisobutyric aciduria pathway; 3-methylcrotonyl CoA carboxylase 1 deficiency pathway; INTERACTS WITH (+)-schisandrin B; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 2-oxoisovalerate dehydrogenase beta subunit; 2-oxoisovalerate dehydrogenase subunit beta, mitochondrial; BCKDE1B; BCKDH E1-beta; branched chain keto acid dehydrogenase E1 beta; branched chain keto acid dehydrogenase E1, beta polypeptide; branched-chain alpha-keto acid dehydrogenase E1 component beta chain
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8893,725,277 - 93,907,799 (+)NCBIGRCr8
mRatBN7.2884,845,264 - 85,027,812 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl884,845,264 - 85,027,812 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx890,455,709 - 90,650,254 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0888,674,196 - 88,861,198 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0886,547,567 - 86,729,703 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0891,464,229 - 91,656,134 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl891,464,229 - 91,656,134 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0890,982,516 - 91,173,706 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4888,997,979 - 89,191,017 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1889,017,545 - 89,210,461 (+)NCBI
Celera884,492,980 - 84,673,845 (+)NCBICelera
RH 3.4 Map8981.4RGD
Cytogenetic Map8q31NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
1,1-dichloroethene  (ISO)
1,2-dimethylhydrazine  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
6-propyl-2-thiouracil  (EXP)
acrylamide  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
amitrole  (EXP)
ammonium chloride  (EXP)
amphetamine  (EXP)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
benzo[a]pyrene  (ISO)
benzo[e]pyrene  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
butanal  (ISO)
C60 fullerene  (EXP)
chromium trinitrate  (ISO)
chromium(6+)  (ISO)
chrysene  (ISO)
cisplatin  (ISO)
cobalt dichloride  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
copper(II) sulfate  (ISO)
coumestrol  (ISO)
Cuprizon  (EXP)
cyclosporin A  (ISO)
dibutyl phthalate  (EXP,ISO)
doxorubicin  (ISO)
ethyl methanesulfonate  (ISO)
folic acid  (ISO)
formaldehyde  (ISO)
glyphosate  (EXP)
indometacin  (EXP)
isotretinoin  (ISO)
ivermectin  (ISO)
maneb  (ISO)
methapyrilene  (ISO)
methimazole  (EXP)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
N-nitrosodiethylamine  (ISO)
N-Nitrosopyrrolidine  (ISO)
nickel atom  (ISO)
nitroglycerin  (EXP)
O-methyleugenol  (ISO)
oxaliplatin  (EXP)
ozone  (ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
phlorizin  (ISO)
pirinixic acid  (ISO)
potassium chromate  (ISO)
resveratrol  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (EXP)
sulfadimethoxine  (EXP)
Tanshinone I  (ISO)
tetrachloromethane  (EXP,ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
topotecan  (EXP)
tunicamycin  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vancomycin  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

References

References - curated
# Reference Title Reference Citation
1. Regulation of gene expression of branched-chain keto acid dehydrogenase complex in primary cultured hepatocytes by dexamethasone and a cAMP analog. Chicco AG, etal., J Biol Chem. 1994 Jul 29;269(30):19427-34.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
4. Posttranscriptional alterations in protein masses of hepatic branched-chain keto acid dehydrogenase and its associated kinase in diabetes. Lombardo YB, etal., Proc Assoc Am Physicians. 1998 Jan-Feb;110(1):40-9.
5. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
6. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
7. Maple syrup urine disease. Complete defect of the E1 beta subunit of the branched chain alpha-ketoacid dehydrogenase complex due to a deletion of an 11-bp repeat sequence which encodes a mitochondrial targeting leader peptide in a family with the disease. Nobukuni Y, etal., J Clin Invest. 1991 May;87(5):1862-6.
8. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
9. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
10. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
11. GOA pipeline RGD automated data pipeline
12. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
13. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
14. Comprehensive gene review and curation RGD comprehensive gene curation
15. Purification of branched chain alpha-ketoacid dehydrogenase complex from rat liver. Shimomura Y, etal., Anal Biochem. 1987 May 15;163(1):74-8.
16. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
17. Effect of dietary protein on the liver content and subunit composition of the branched-chain alpha-ketoacid dehydrogenase complex. Zhao Y, etal., Arch Biochem Biophys. 1994 Feb 1;308(2):446-53.
18. Molecular cloning of the E1 beta subunit of the rat branched chain alpha-ketoacid dehydrogenase. Zhao Y, etal., Biochim Biophys Acta 1992 Sep 24;1132(2):207-10.
Additional References at PubMed
PMID:1377677   PMID:7841205   PMID:8889548   PMID:9611264   PMID:12477932   PMID:15326124   PMID:18614015   PMID:24625528   PMID:25193403  


Genomics

Comparative Map Data
Bckdhb
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8893,725,277 - 93,907,799 (+)NCBIGRCr8
mRatBN7.2884,845,264 - 85,027,812 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl884,845,264 - 85,027,812 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx890,455,709 - 90,650,254 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0888,674,196 - 88,861,198 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0886,547,567 - 86,729,703 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0891,464,229 - 91,656,134 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl891,464,229 - 91,656,134 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0890,982,516 - 91,173,706 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4888,997,979 - 89,191,017 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1889,017,545 - 89,210,461 (+)NCBI
Celera884,492,980 - 84,673,845 (+)NCBICelera
RH 3.4 Map8981.4RGD
Cytogenetic Map8q31NCBI
BCKDHB
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38680,106,610 - 80,466,676 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl680,106,647 - 80,346,270 (+)EnsemblGRCh38hg38GRCh38
GRCh37680,816,327 - 81,055,987 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36680,873,083 - 81,112,706 (+)NCBINCBI36Build 36hg18NCBI36
Build 34680,873,082 - 81,112,706NCBI
Celera681,237,906 - 81,477,561 (+)NCBICelera
Cytogenetic Map6q14.1NCBI
HuRef678,039,157 - 78,278,814 (+)NCBIHuRef
CHM1_1680,913,790 - 81,153,760 (+)NCBICHM1_1
T2T-CHM13v2.0681,315,017 - 81,677,450 (+)NCBIT2T-CHM13v2.0
Bckdhb
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39983,807,190 - 84,006,293 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl983,807,198 - 84,006,293 (+)EnsemblGRCm39 Ensembl
GRCm38983,925,111 - 84,124,240 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl983,925,145 - 84,124,240 (+)EnsemblGRCm38mm10GRCm38
MGSCv37983,842,388 - 84,017,847 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36983,745,499 - 83,920,958 (+)NCBIMGSCv36mm8
Celera981,044,884 - 81,213,851 (+)NCBICelera
Cytogenetic Map9E2NCBI
cM Map945.67NCBI
Bckdhb
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554118,437,548 - 8,628,363 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554118,427,875 - 8,626,564 (+)NCBIChiLan1.0ChiLan1.0
BCKDHB
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v25100,209,447 - 100,462,843 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1698,088,586 - 98,340,102 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0678,005,287 - 78,246,287 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1681,277,085 - 81,516,787 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl681,276,836 - 81,516,787 (+)Ensemblpanpan1.1panPan2
BCKDHB
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11241,009,798 - 41,224,802 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1241,009,730 - 41,224,802 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1240,881,519 - 41,096,408 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01241,775,384 - 41,991,512 (+)NCBIROS_Cfam_1.0
UMICH_Zoey_3.11241,088,764 - 41,303,619 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01241,063,571 - 41,271,816 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01241,216,793 - 41,431,727 (+)NCBIUU_Cfam_GSD_1.0
Bckdhb
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494676,389,357 - 76,568,118 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365109,902,670 - 10,081,587 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365109,904,703 - 10,081,532 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
BCKDHB
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl185,755,743 - 86,017,650 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1185,755,819 - 86,017,661 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2196,353,433 - 96,716,539 (-)NCBISscrofa10.2Sscrofa10.2susScr3
BCKDHB
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1134,845,481 - 5,087,558 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl134,845,457 - 5,087,745 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666040181,063,803 - 181,307,482 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Bckdhb
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462479914,182,863 - 14,368,618 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462479914,182,951 - 14,368,568 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Bckdhb
1461 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:28
Count of miRNA genes:26
Interacting mature miRNAs:28
Transcripts:ENSRNOT00000013249
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1581557Eae16Experimental allergic encephalomyelitis QTL 163.8nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)88462195110921472Rat
631650Stl6Serum triglyceride level QTL 640.0019blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)810378157112202585Rat
731182Uae24Urinary albumin excretion QTL 246.4urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)81933115293965294Rat
1358892Kidm26Kidney mass QTL 263.69kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)82720571599103503Rat
1358896Bp262Blood pressure QTL 2622.89arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)82720571599103503Rat
1358907Cm40Cardiac mass QTL 401.89heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)82720571599103503Rat
8662823Vetf5Vascular elastic tissue fragility QTL 51.9artery integrity trait (VT:0010639)patent ductus arteriosus score (CMO:0002566)82824291299525068Rat
1549908Neudeg1Neurodegradation QTL 15.50nervous system integrity trait (VT:0010566)logarithm of the ratio of the lesioned side motor neuron count to contralateral side motor neuron count (CMO:0001986)83018886794457446Rat
1578755Pur5Proteinuria QTL 53.30.0001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)830848154101699754Rat
1578765Klgr1Kidney lesion grade QTL 13.30.0001kidney morphology trait (VT:0002135)organ lesion measurement (CMO:0000677)830848154101699754Rat
1578769Uae31Urinary albumin excretion QTL 313.30.001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)830848154101699754Rat
2316950Scl66Serum cholesterol level QTL 664.1blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)830848259105647037Rat
1331838Niddm61Non-insulin dependent diabetes mellitus QTL 613.530.0004blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)83646953599083736Rat
1358906Bp253Blood pressure QTL 25340.0004arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)84071306693965294Rat
1554321Bmd3Bone mineral density QTL 37.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)840952565123900184Rat
1298079Activ2Activity QTL 29.50.000001voluntary movement trait (VT:0003491)rearing measurement (CMO:0001515)84186687686866876Rat
70161Bp62Blood pressure QTL 622.90.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)84269268490165460Rat
12879882Am8Aortic mass QTL 80.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)84329616998968765Rat
12879878Bw183Body weight QTL 1830.001body mass (VT:0001259)body weight (CMO:0000012)84329616998968765Rat
12879879Cm99Cardiac mass QTL 990.001heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)84329616998968765Rat
12879880Cm100Cardiac mass QTL 1000.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)84329616998968765Rat
12879881Cm101Cardiac mass QTL 1010.001heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)84329616998968765Rat
12879883Kidm65Kidney mass QTL 650.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)84329616998968765Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)846531639119088626Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)846531639119088626Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)absolute change in systolic blood pressure (CMO:0000607)846531639119088626Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)846531639119088626Rat
1331837Bw23Body weight QTL 234.190.00007body mass (VT:0001259)body weight (CMO:0000012)84653172299083736Rat
2303570Gluco48Glucose level QTL 482blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)84980583194805831Rat
1358912Bw51Body weight QTL 512.95body mass (VT:0001259)body weight (CMO:0000012)851351728107062046Rat
10402857Bp380Blood pressure QTL 3800.95arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)85396876598968765Rat
2301402Bp316Blood pressure QTL 3160.005arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)85396876598968765Rat
2293697Bmd39Bone mineral density QTL 39femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)85404374498968765Rat
1582243Bw66Body weight QTL 663.40.0048body mass (VT:0001259)body weight (CMO:0000012)85423764485365202Rat
1582254Kidm31Kidney mass QTL 313kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)85423764485365202Rat
631664Hcar3Hepatocarcinoma resistance QTL 32.90.0005liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)85423764499103503Rat
1300177Cm2Cardiac mass QTL 23.65heart mass (VT:0007028)heart weight (CMO:0000017)854259986100382532Rat
2303171Bp331Blood pressure QTL 3315.570.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)861290298119084929Rat
631653Bp125Blood pressure QTL 1253.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)866142385111142385Rat
631210Bw3Body weight QTL35.9mesenteric fat pad mass (VT:0010427)mesenteric fat pad weight to body weight ratio (CMO:0000654)869349194112783834Rat
1300171Bp184Blood pressure QTL 1843.66arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)870513503118219066Rat
8694446Bw170Body weight QTL 17012.070.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)871888757116888757Rat
9590292Uminl3Urine mineral level QTL 33.620.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)871888757116888757Rat
8694200Abfw4Abdominal fat weight QTL 49.070.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)871888757116888757Rat
8694392Bw161Body weight QTL 1618.060.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)871888757116888757Rat
1549909Stresp11Stress response QTL 116.830.0019stress-related behavior trait (VT:0010451)number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)873473045118473045Rat
2300181Bmd55Bone mineral density QTL 555.70.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)876468691121468691Rat
61437Cia6Collagen induced arthritis QTL 6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)882460758122812818Rat

Markers in Region
D8Rat138  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2884,911,931 - 84,912,228 (+)MAPPERmRatBN7.2
Rnor_6.0891,530,881 - 91,531,177NCBIRnor6.0
Rnor_5.0891,049,017 - 91,049,313UniSTSRnor5.0
RGSC_v3.4889,064,468 - 89,064,925RGDRGSC3.4
RGSC_v3.4889,064,544 - 89,064,840UniSTSRGSC3.4
RGSC_v3.1889,083,999 - 89,084,295RGD
Celera884,559,684 - 84,559,980UniSTS
RH 3.4 Map8980.5RGD
RH 3.4 Map8980.5UniSTS
RH 2.0 Map8772.9RGD
SHRSP x BN Map848.21RGD
Cytogenetic Map8q31UniSTS
BE104808  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2885,010,652 - 85,010,823 (+)MAPPERmRatBN7.2
Rnor_6.0891,639,015 - 91,639,185NCBIRnor6.0
Rnor_5.0891,156,322 - 91,156,492UniSTSRnor5.0
RGSC_v3.4889,173,539 - 89,173,709UniSTSRGSC3.4
Celera884,656,087 - 84,656,257UniSTS
RH 3.4 Map8980.5UniSTS
Cytogenetic Map8q31UniSTS
RH142183  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2885,027,619 - 85,027,786 (+)MAPPERmRatBN7.2
Rnor_6.0891,655,942 - 91,656,108NCBIRnor6.0
Rnor_5.0891,173,512 - 91,173,678UniSTSRnor5.0
RGSC_v3.4889,190,825 - 89,190,991UniSTSRGSC3.4
Celera884,673,653 - 84,673,819UniSTS
RH 3.4 Map8981.4UniSTS
Cytogenetic Map8q31UniSTS
BE114464  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2884,843,984 - 84,844,169 (+)MAPPERmRatBN7.2
Rnor_6.0891,462,950 - 91,463,134NCBIRnor6.0
Rnor_5.0890,981,240 - 90,981,424UniSTSRnor5.0
RGSC_v3.4888,996,700 - 88,996,884UniSTSRGSC3.4
Celera884,491,701 - 84,491,885UniSTS
RH 3.4 Map8980.5UniSTS
Cytogenetic Map8q31UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 43 57 41 19 41 8 11 74 35 34 11 8
Low 7
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000013249   ⟹   ENSRNOP00000013249
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl884,845,264 - 85,027,812 (+)Ensembl
Rnor_6.0 Ensembl891,464,229 - 91,656,134 (+)Ensembl
RefSeq Acc Id: NM_019267   ⟹   NP_062140
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8893,725,277 - 93,907,799 (+)NCBI
mRatBN7.2884,845,264 - 85,027,812 (+)NCBI
Rnor_6.0891,464,229 - 91,656,134 (+)NCBI
Rnor_5.0890,982,516 - 91,173,706 (+)NCBI
RGSC_v3.4888,997,979 - 89,191,017 (+)RGD
Celera884,492,980 - 84,673,845 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_062140 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA73899 (Get FASTA)   NCBI Sequence Viewer  
  AAI58862 (Get FASTA)   NCBI Sequence Viewer  
  EDL77651 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000013249
  ENSRNOP00000013249.7
  ENSRNOP00060029951
GenBank Protein P35738 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: NP_062140   ⟸   NM_019267
- Peptide Label: precursor
- UniProtKB: P35738 (UniProtKB/Swiss-Prot),   A6I1S6 (UniProtKB/TrEMBL),   A0A0A0MXW1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000013249   ⟸   ENSRNOT00000013249
Protein Domains
Transketolase-like pyrimidine-binding

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P35738-F1-model_v2 AlphaFold P35738 1-390 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13696155
Promoter ID:EPDNEW_R6680
Type:multiple initiation site
Name:Bckdhb_1
Description:branched chain keto acid dehydrogenase E1 subunit beta
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0891,464,246 - 91,464,306EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2197 AgrOrtholog
BioCyc Gene G2FUF-29671 BioCyc
BioCyc Pathway ILEUDEG-PWY [L-isoleucine degradation I] BioCyc
  LEU-DEG2-PWY [L-leucine degradation I] BioCyc
  PWY-5046 [2-oxoisovalerate decarboxylation to isobutanoyl-CoA] BioCyc
  PWY-5130 [2-oxobutanoate degradation I] BioCyc
  PWY66-428 [L-threonine degradation V] BioCyc
  VALDEG-PWY [L-valine degradation I] BioCyc
BioCyc Pathway Image ILEUDEG-PWY BioCyc
  LEU-DEG2-PWY BioCyc
  PWY-5046 BioCyc
  PWY-5130 BioCyc
  PWY66-428 BioCyc
  VALDEG-PWY BioCyc
Ensembl Genes ENSRNOG00000009928 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00060020994 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000013249 ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOT00000013249.7 UniProtKB/Swiss-Prot
  ENSRNOT00060036386 UniProtKB/Swiss-Prot
Gene3D-CATH 3.40.50.920 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.40.50.970 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7932093 IMAGE-MGC_LOAD
InterPro THDP-binding UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Transketo_C/PFOR_II UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Transketolase-like_Pyr-bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Transketolase_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:29711 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:188428 IMAGE-MGC_LOAD
NCBI Gene 29711 ENTREZGENE
PANTHER 2-OXOISOVALERATE DEHYDROGENASE SUBUNIT BETA, MITOCHONDRIAL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2-OXOISOVALERATE DEHYDROGENASE SUBUNIT BETA-RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Transket_pyr UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Transketolase_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Bckdhb PhenoGen
RatGTEx ENSRNOG00000009928 RatGTEx
  ENSRNOG00060020994 RatGTEx
SMART Transket_pyr UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF52518 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF52922 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC206577
UniProt A0A0A0MXW1 ENTREZGENE, UniProtKB/TrEMBL
  A6I1S6 ENTREZGENE, UniProtKB/TrEMBL
  B0BNK6_RAT UniProtKB/TrEMBL
  ODBB_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-07-13 Bckdhb  branched chain keto acid dehydrogenase E1 subunit beta  Bckdhb  branched chain keto acid dehydrogenase E1, beta polypeptide  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Bckdhb  branched chain keto acid dehydrogenase E1, beta polypeptide      Symbol and Name status set to approved 70586 APPROVED