Speg (striated muscle enriched protein kinase) - Rat Genome Database

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Gene: Speg (striated muscle enriched protein kinase) Rattus norvegicus
Analyze
Symbol: Speg
Name: striated muscle enriched protein kinase
RGD ID: 2124
Description: Predicted to enable protein kinase activity. Involved in muscle cell differentiation. Predicted to be located in nucleus. Human ortholog(s) of this gene implicated in centronuclear myopathy 5. Orthologous to human SPEG (striated muscle enriched protein kinase); INTERACTS WITH 17alpha-ethynylestradiol; acetamide; ammonium chloride.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: aortic preferentially expressed gene 1; aortic preferentially expressed protein 1; APEG-1; Apeg1; LOC363256; similar to aortic preferentially expressed gene 1; SPEG complex locus; striated muscle-specific serine/threonine-protein kinase
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8984,314,387 - 84,371,816 (+)NCBIGRCr8
mRatBN7.2976,865,714 - 76,923,170 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl976,865,754 - 76,923,144 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx985,310,241 - 85,367,619 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0990,439,123 - 90,496,499 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0988,825,304 - 88,882,675 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0982,571,333 - 82,628,684 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl982,571,269 - 82,628,709 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0982,340,581 - 82,397,945 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4974,652,526 - 74,709,904 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1974,824,554 - 74,828,988 (+)NCBI
Celera974,435,692 - 74,492,957 (+)NCBICelera
Cytogenetic Map9q33NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
nucleus  (IEA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. APEG-1, a novel gene preferentially expressed in aortic smooth muscle cells, is down-regulated by vascular injury. Hsieh CM, etal., J Biol Chem 1996 Jul 19;271(29):17354-9.
3. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
4. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
6. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
Additional References at PubMed
PMID:10973969   PMID:12477932   PMID:15057822   PMID:19118250   PMID:31790338  


Genomics

Comparative Map Data
Speg
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8984,314,387 - 84,371,816 (+)NCBIGRCr8
mRatBN7.2976,865,714 - 76,923,170 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl976,865,754 - 76,923,144 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx985,310,241 - 85,367,619 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0990,439,123 - 90,496,499 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0988,825,304 - 88,882,675 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0982,571,333 - 82,628,684 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl982,571,269 - 82,628,709 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0982,340,581 - 82,397,945 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4974,652,526 - 74,709,904 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1974,824,554 - 74,828,988 (+)NCBI
Celera974,435,692 - 74,492,957 (+)NCBICelera
Cytogenetic Map9q33NCBI
SPEG
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382219,434,843 - 219,493,629 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2219,434,843 - 219,493,629 (+)EnsemblGRCh38hg38GRCh38
GRCh372220,299,565 - 220,358,351 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362220,007,944 - 220,066,598 (+)NCBINCBI36Build 36hg18NCBI36
Build 342220,133,900 - 220,157,088NCBI
Celera2214,069,692 - 214,128,346 (+)NCBICelera
Cytogenetic Map2q35NCBI
HuRef2212,152,724 - 212,211,419 (+)NCBIHuRef
CHM1_12220,305,523 - 220,364,193 (+)NCBICHM1_1
T2T-CHM13v2.02219,919,623 - 219,978,369 (+)NCBIT2T-CHM13v2.0
Speg
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39175,351,931 - 75,408,964 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl175,351,941 - 75,408,964 (+)EnsemblGRCm39 Ensembl
GRCm38175,375,297 - 75,432,320 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl175,375,297 - 75,432,320 (+)EnsemblGRCm38mm10GRCm38
MGSCv37175,371,872 - 75,428,889 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36175,258,445 - 75,315,462 (+)NCBIMGSCv36mm8
Celera175,865,860 - 75,923,244 (+)NCBICelera
Cytogenetic Map1C4NCBI
cM Map138.88NCBI
Speg
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545313,976,674 - 14,033,252 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495545313,979,080 - 14,033,718 (-)NCBIChiLan1.0ChiLan1.0
SPEG
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v213122,065,106 - 122,123,484 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12B122,080,072 - 122,138,450 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B106,692,222 - 106,750,922 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B225,282,554 - 225,340,753 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B225,282,676 - 225,339,910 (+)Ensemblpanpan1.1panPan2
SPEG
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13725,947,605 - 26,005,601 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3725,947,773 - 26,005,601 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3726,773,599 - 26,831,117 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03725,963,015 - 26,020,671 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3725,963,015 - 26,020,671 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13725,866,874 - 25,924,631 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03725,802,876 - 25,860,720 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03725,823,459 - 25,881,304 (+)NCBIUU_Cfam_GSD_1.0
Speg
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303175,484,247 - 175,534,225 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365691,821,143 - 1,876,156 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365691,821,125 - 1,877,006 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SPEG
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.115121,443,976 - 121,501,453 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.215134,640,604 - 134,688,490 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SPEG
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.110105,330,171 - 105,388,657 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl10105,330,171 - 105,387,810 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604094,012,325 - 94,070,649 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Speg
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248235,564,550 - 5,618,786 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248235,563,687 - 5,618,786 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Speg
249 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:350
Count of miRNA genes:190
Interacting mature miRNAs:242
Transcripts:ENSRNOT00000026941, ENSRNOT00000065076
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
10054125Srcrt7Stress Responsive Cort QTL 73.330.0011blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)9187073594Rat
70186Niddm26Non-insulin dependent diabetes mellitus QTL 263.87blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)92207116986369743Rat
7207814Bmd91Bone mineral density QTL 913.5femur size trait (VT:1000369)femoral neck cross-sectional area (CMO:0001697)92375414483851531Rat
70218Cm28Cardiac mass QTL 288.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)92526804479271759Rat
724544Uae9Urinary albumin excretion QTL 94.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)925268044114175309Rat
731164Uae25Urinary albumin excretion QTL 253.50.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)925661188100929786Rat
7411656Foco26Food consumption QTL 269.80.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)93253550577535505Rat
7411571Bw138Body weight QTL 13814.30.001body mass (VT:0001259)body weight gain (CMO:0000420)93253550577535505Rat
1598834Memor11Memory QTL 112.5exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)93696235977814038Rat
8662828Vetf6Vascular elastic tissue fragility QTL 63.9artery integrity trait (VT:0010639)patent ductus arteriosus score (CMO:0002566)93696235992058970Rat
2290450Scl57Serum cholesterol level QTL 574.15blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)93696235995410867Rat
6903941Pur31Proteinuria QTL 310.036urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)94019418885194188Rat
11353949Bp393Blood pressure QTL 393arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)94019418885194188Rat
61352Bp34Blood pressure QTL 345arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)94249534379271511Rat
10058949Gmadr5Adrenal mass QTL 520.014adrenal gland mass (VT:0010420)both adrenal glands wet weight to body weight ratio (CMO:0002411)94279151387976209Rat
11353951Bp394Blood pressure QTL 394arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)94464992189649921Rat
12879506Pur33Proteinuria QTL 33urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)94464992189649921Rat
11353957Bmd92Bone mineral density QTL 920.01tibia mineral mass (VT:1000283)volumetric bone mineral density (CMO:0001553)94611419991114199Rat
631656Bp108Blood pressure QTL 1085.970.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)94859825193598251Rat
2303170Bp332Blood pressure QTL 3323.730.027arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)95584784177026453Rat
2303180Bp333Blood pressure QTL 3330.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)95662771378595166Rat
2303180Bp333Blood pressure QTL 3330.001arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)95662771378595166Rat
2303180Bp333Blood pressure QTL 3330.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)95662771378595166Rat
1578760Cm53Cardiac mass QTL 533.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)956771635101771635Rat
724515Uae16Urinary albumin excretion QTL 168urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)958163035100929646Rat
1300134Bp185Blood pressure QTL 1853.73arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)961381434104821652Rat
1581580Uae34Urinary albumin excretion QTL 34urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)96207227596470995Rat
1578757Pur6Proteinuria QTL 63.30.005urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)96207227596470995Rat
61385Edpm9Estrogen-dependent pituitary mass QTL 93.430.05pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)963869687108869687Rat
731171Glom6Glomerulus QTL 62.80.0003kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)964573531109573531Rat
1354626Bvd1Brain ventricular dilatation QTL 13.730.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)975712843111552878Rat

Markers in Region
D9Rat8  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2976,902,954 - 76,903,085 (+)MAPPERmRatBN7.2
Rnor_6.0982,608,497 - 82,608,627NCBIRnor6.0
Rnor_5.0982,377,758 - 82,377,888UniSTSRnor5.0
RGSC_v3.4974,689,716 - 74,689,847RGDRGSC3.4
RGSC_v3.4974,689,717 - 74,689,847UniSTSRGSC3.4
RGSC_v3.1974,836,699 - 74,836,829RGD
Celera974,472,770 - 74,472,900UniSTS
RH 3.4 Map9774.2UniSTS
RH 3.4 Map9774.2RGD
SHRSP x BN Map951.1998UniSTS
SHRSP x BN Map951.1998RGD
Cytogenetic Map9q33UniSTS
D9Mco71  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2976,874,236 - 76,874,409 (+)MAPPERmRatBN7.2
Rnor_6.0982,579,829 - 82,580,001NCBIRnor6.0
Rnor_5.0982,349,090 - 82,349,262UniSTSRnor5.0
RGSC_v3.4974,661,010 - 74,661,182UniSTSRGSC3.4
Celera974,444,176 - 74,444,348UniSTS
Cytogenetic Map9q33UniSTS
U57098  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2976,894,867 - 76,894,951 (+)MAPPERmRatBN7.2
Rnor_6.0982,600,459 - 82,600,542NCBIRnor6.0
Rnor_5.0982,369,720 - 82,369,803UniSTSRnor5.0
RGSC_v3.4974,681,640 - 74,681,723UniSTSRGSC3.4
Celera974,464,804 - 74,464,887UniSTS
Cytogenetic Map9q33UniSTS
RH128701  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2976,895,074 - 76,895,229 (+)MAPPERmRatBN7.2
Rnor_6.0982,600,666 - 82,600,820NCBIRnor6.0
Rnor_5.0982,369,927 - 82,370,081UniSTSRnor5.0
RGSC_v3.4974,681,847 - 74,682,001UniSTSRGSC3.4
Celera974,465,011 - 74,465,165UniSTS
RH 3.4 Map9711.39UniSTS
Cytogenetic Map9q33UniSTS
BE098213  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2976,922,385 - 76,922,552 (+)MAPPERmRatBN7.2
Rnor_6.0982,627,926 - 82,628,092NCBIRnor6.0
Rnor_5.0982,397,187 - 82,397,353UniSTSRnor5.0
RGSC_v3.4974,709,146 - 74,709,312UniSTSRGSC3.4
Celera974,492,199 - 74,492,365UniSTS
RH 3.4 Map9757.79UniSTS
Cytogenetic Map9q33UniSTS
RH139048  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2976,873,926 - 76,874,070 (+)MAPPERmRatBN7.2
Rnor_6.0982,579,519 - 82,579,662NCBIRnor6.0
Rnor_5.0982,348,780 - 82,348,923UniSTSRnor5.0
RGSC_v3.4974,660,700 - 74,660,843UniSTSRGSC3.4
Celera974,443,866 - 74,444,009UniSTS
RH 3.4 Map9757.29UniSTS
Cytogenetic Map9q33UniSTS
D1Bwg1450e  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2976,922,880 - 76,923,057 (+)MAPPERmRatBN7.2
Rnor_6.0982,628,421 - 82,628,597NCBIRnor6.0
Rnor_5.0982,397,682 - 82,397,858UniSTSRnor5.0
RGSC_v3.4974,709,641 - 74,709,817UniSTSRGSC3.4
Celera974,492,694 - 74,492,870UniSTS
Cytogenetic Map9q33UniSTS
REN52878  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2976,878,241 - 76,878,464 (+)MAPPERmRatBN7.2
Rnor_6.0982,583,834 - 82,584,056NCBIRnor6.0
Rnor_5.0982,353,095 - 82,353,317UniSTSRnor5.0
RGSC_v3.4974,665,015 - 74,665,237UniSTSRGSC3.4
Celera974,448,181 - 74,448,403UniSTS
Cytogenetic Map9q33UniSTS
REN53031  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2976,912,843 - 76,913,078 (+)MAPPERmRatBN7.2
Rnor_6.0982,618,386 - 82,618,620NCBIRnor6.0
Rnor_5.0982,387,647 - 82,387,881UniSTSRnor5.0
RGSC_v3.4974,699,606 - 74,699,840UniSTSRGSC3.4
Celera974,482,659 - 74,482,893UniSTS
Cytogenetic Map9q33UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 37 8 11 25 5 8
Low 3 6 24 8 19 8 49 35 36 11
Below cutoff 33 33 33

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001108802 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_012905 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006245252 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006245255 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006245256 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008767267 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008767268 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008767269 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008767270 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008767271 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017596526 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017596527 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017596528 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017596529 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039083887 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039083888 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039083890 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039083892 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039083893 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063267412 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063267413 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063267414 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063267415 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063267416 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063267417 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063267418 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063267419 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC112361 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC087690 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH474004 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EV763588 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000009 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U57097 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: ENSRNOT00000026941   ⟹   ENSRNOP00000026941
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl976,865,754 - 76,923,144 (+)Ensembl
Rnor_6.0 Ensembl982,571,269 - 82,628,709 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000065076   ⟹   ENSRNOP00000063082
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl976,890,719 - 76,895,230 (+)Ensembl
Rnor_6.0 Ensembl982,596,355 - 82,600,826 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000098450   ⟹   ENSRNOP00000084140
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl976,872,686 - 76,895,232 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000114940   ⟹   ENSRNOP00000091308
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl976,865,754 - 76,923,144 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000115275   ⟹   ENSRNOP00000079646
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl976,872,686 - 76,895,232 (+)Ensembl
RefSeq Acc Id: NM_001108802   ⟹   NP_001102272
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8984,314,387 - 84,371,813 (+)NCBI
mRatBN7.2976,865,738 - 76,923,167 (+)NCBI
Rnor_6.0982,571,345 - 82,628,684 (+)NCBI
Rnor_5.0982,340,581 - 82,397,945 (+)NCBI
RGSC_v3.4974,652,526 - 74,709,904 (+)RGD
Celera974,435,692 - 74,492,957 (+)RGD
Sequence:
RefSeq Acc Id: NM_012905   ⟹   NP_037037
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8984,339,412 - 84,343,883 (+)NCBI
mRatBN7.2976,890,763 - 76,895,235 (+)NCBI
Rnor_6.0982,596,355 - 82,600,826 (+)NCBI
Rnor_5.0982,340,581 - 82,397,945 (+)NCBI
Celera974,460,700 - 74,465,171 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006245252   ⟹   XP_006245314
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8984,320,978 - 84,371,816 (+)NCBI
mRatBN7.2976,872,319 - 76,923,170 (+)NCBI
Rnor_6.0982,577,890 - 82,628,280 (+)NCBI
Rnor_5.0982,340,581 - 82,397,945 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006245255   ⟹   XP_006245317
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8984,330,970 - 84,371,816 (+)NCBI
mRatBN7.2976,888,438 - 76,923,170 (+)NCBI
Rnor_6.0982,594,065 - 82,628,280 (+)NCBI
Rnor_5.0982,340,581 - 82,397,945 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006245256   ⟹   XP_006245318
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8984,339,572 - 84,371,816 (+)NCBI
mRatBN7.2976,890,917 - 76,923,170 (+)NCBI
Rnor_6.0982,596,456 - 82,628,280 (+)NCBI
Rnor_5.0982,340,581 - 82,397,945 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017596526   ⟹   XP_017452015
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8984,321,265 - 84,371,816 (+)NCBI
mRatBN7.2976,872,616 - 76,923,170 (+)NCBI
Rnor_6.0982,578,257 - 82,628,280 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017596527   ⟹   XP_017452016
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8984,321,284 - 84,371,816 (+)NCBI
mRatBN7.2976,872,587 - 76,923,170 (+)NCBI
Rnor_6.0982,578,225 - 82,628,280 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017596528   ⟹   XP_017452017
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8984,324,714 - 84,371,816 (+)NCBI
mRatBN7.2976,876,064 - 76,923,170 (+)NCBI
Rnor_6.0982,581,641 - 82,628,280 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017596529   ⟹   XP_017452018
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8984,324,388 - 84,371,816 (+)NCBI
mRatBN7.2976,875,739 - 76,923,170 (+)NCBI
Rnor_6.0982,581,756 - 82,628,280 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039083887   ⟹   XP_038939815
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8984,314,398 - 84,371,816 (+)NCBI
mRatBN7.2976,865,726 - 76,923,170 (+)NCBI
RefSeq Acc Id: XM_039083888   ⟹   XP_038939816
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8984,314,398 - 84,371,816 (+)NCBI
mRatBN7.2976,865,726 - 76,923,170 (+)NCBI
RefSeq Acc Id: XM_039083890   ⟹   XP_038939818
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8984,324,275 - 84,371,816 (+)NCBI
mRatBN7.2976,875,611 - 76,923,170 (+)NCBI
RefSeq Acc Id: XM_039083892   ⟹   XP_038939820
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8984,314,398 - 84,343,883 (+)NCBI
mRatBN7.2976,865,714 - 76,895,236 (+)NCBI
RefSeq Acc Id: XM_039083893   ⟹   XP_038939821
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8984,314,398 - 84,343,883 (+)NCBI
mRatBN7.2976,865,717 - 76,895,236 (+)NCBI
RefSeq Acc Id: XM_063267412   ⟹   XP_063123482
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8984,314,398 - 84,371,816 (+)NCBI
RefSeq Acc Id: XM_063267413   ⟹   XP_063123483
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8984,324,734 - 84,371,816 (+)NCBI
RefSeq Acc Id: XM_063267414   ⟹   XP_063123484
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8984,321,240 - 84,343,883 (+)NCBI
RefSeq Acc Id: XM_063267415   ⟹   XP_063123485
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8984,314,398 - 84,343,883 (+)NCBI
RefSeq Acc Id: XM_063267416   ⟹   XP_063123486
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8984,314,393 - 84,343,883 (+)NCBI
RefSeq Acc Id: XM_063267417   ⟹   XP_063123487
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8984,320,971 - 84,343,883 (+)NCBI
RefSeq Acc Id: XM_063267418   ⟹   XP_063123488
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8984,321,247 - 84,343,883 (+)NCBI
RefSeq Acc Id: XM_063267419   ⟹   XP_063123489
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8984,321,252 - 84,343,883 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001102272 (Get FASTA)   NCBI Sequence Viewer  
  NP_037037 (Get FASTA)   NCBI Sequence Viewer  
  XP_006245314 (Get FASTA)   NCBI Sequence Viewer  
  XP_006245317 (Get FASTA)   NCBI Sequence Viewer  
  XP_006245318 (Get FASTA)   NCBI Sequence Viewer  
  XP_017452015 (Get FASTA)   NCBI Sequence Viewer  
  XP_017452016 (Get FASTA)   NCBI Sequence Viewer  
  XP_017452017 (Get FASTA)   NCBI Sequence Viewer  
  XP_017452018 (Get FASTA)   NCBI Sequence Viewer  
  XP_038939815 (Get FASTA)   NCBI Sequence Viewer  
  XP_038939816 (Get FASTA)   NCBI Sequence Viewer  
  XP_038939818 (Get FASTA)   NCBI Sequence Viewer  
  XP_038939820 (Get FASTA)   NCBI Sequence Viewer  
  XP_038939821 (Get FASTA)   NCBI Sequence Viewer  
  XP_063123482 (Get FASTA)   NCBI Sequence Viewer  
  XP_063123483 (Get FASTA)   NCBI Sequence Viewer  
  XP_063123484 (Get FASTA)   NCBI Sequence Viewer  
  XP_063123485 (Get FASTA)   NCBI Sequence Viewer  
  XP_063123486 (Get FASTA)   NCBI Sequence Viewer  
  XP_063123487 (Get FASTA)   NCBI Sequence Viewer  
  XP_063123488 (Get FASTA)   NCBI Sequence Viewer  
  XP_063123489 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAC52667 (Get FASTA)   NCBI Sequence Viewer  
  EDL75436 (Get FASTA)   NCBI Sequence Viewer  
  EDL75437 (Get FASTA)   NCBI Sequence Viewer  
  EDL75438 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000026941
  ENSRNOP00000026941.4
  ENSRNOP00000063082.2
  ENSRNOP00000079646
  ENSRNOP00000079646.1
  ENSRNOP00000084140
  ENSRNOP00000084140.1
  ENSRNOP00000091308.1
GenBank Protein Q63638 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001102272   ⟸   NM_001108802
- Peptide Label: isoform 1
- UniProtKB: Q63638 (UniProtKB/Swiss-Prot),   A6JW28 (UniProtKB/TrEMBL),   A0A8I6ADG2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_037037   ⟸   NM_012905
- Peptide Label: isoform 4
- UniProtKB: A0A8L2QUK8 (UniProtKB/TrEMBL),   A6JW29 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006245314   ⟸   XM_006245252
- Peptide Label: isoform X6
- Sequence:
RefSeq Acc Id: XP_006245317   ⟸   XM_006245255
- Peptide Label: isoform X7
- Sequence:
RefSeq Acc Id: XP_006245318   ⟸   XM_006245256
- Peptide Label: isoform X7
- Sequence:
RefSeq Acc Id: XP_017452016   ⟸   XM_017596527
- Peptide Label: isoform X5
- UniProtKB: A0A8I6ADG2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017452015   ⟸   XM_017596526
- Peptide Label: isoform X4
- UniProtKB: A0A8I6ADG2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017452017   ⟸   XM_017596528
- Peptide Label: isoform X6
- Sequence:
RefSeq Acc Id: XP_017452018   ⟸   XM_017596529
- Peptide Label: isoform X6
- Sequence:
RefSeq Acc Id: ENSRNOP00000063082   ⟸   ENSRNOT00000065076
RefSeq Acc Id: ENSRNOP00000026941   ⟸   ENSRNOT00000026941
RefSeq Acc Id: XP_038939820   ⟸   XM_039083892
- Peptide Label: isoform X8
RefSeq Acc Id: XP_038939821   ⟸   XM_039083893
- Peptide Label: isoform X9
- UniProtKB: A0A8I5ZN28 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038939815   ⟸   XM_039083887
- Peptide Label: isoform X1
- UniProtKB: A0A8I6ADG2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038939816   ⟸   XM_039083888
- Peptide Label: isoform X3
- UniProtKB: A0A8I6ADG2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038939818   ⟸   XM_039083890
- Peptide Label: isoform X6
RefSeq Acc Id: ENSRNOP00000079646   ⟸   ENSRNOT00000115275
RefSeq Acc Id: ENSRNOP00000084140   ⟸   ENSRNOT00000098450
RefSeq Acc Id: ENSRNOP00000091308   ⟸   ENSRNOT00000114940
RefSeq Acc Id: XP_063123486   ⟸   XM_063267416
- Peptide Label: isoform X12
- UniProtKB: A0A8I5ZN28 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063123482   ⟸   XM_063267412
- Peptide Label: isoform X2
- UniProtKB: A0A8I6ADG2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063123485   ⟸   XM_063267415
- Peptide Label: isoform X11
- UniProtKB: A0A8I5ZN28 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063123487   ⟸   XM_063267417
- Peptide Label: isoform X13
RefSeq Acc Id: XP_063123484   ⟸   XM_063267414
- Peptide Label: isoform X10
- UniProtKB: A0A8I5ZN28 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063123488   ⟸   XM_063267418
- Peptide Label: isoform X14
- UniProtKB: A0A8I5ZN28 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063123489   ⟸   XM_063267419
- Peptide Label: isoform X15
- UniProtKB: A0A8I5ZN28 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063123483   ⟸   XM_063267413
- Peptide Label: isoform X6
Protein Domains
Fibronectin type-III   Ig-like   Protein kinase

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2124 AgrOrtholog
BioCyc Gene G2FUF-27073 BioCyc
Ensembl Genes ENSRNOG00000019850 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000026941 ENTREZGENE
  ENSRNOT00000026941.8 UniProtKB/Swiss-Prot
  ENSRNOT00000065076.3 UniProtKB/TrEMBL
  ENSRNOT00000098450 ENTREZGENE
  ENSRNOT00000098450.1 UniProtKB/Swiss-Prot
  ENSRNOT00000114940.1 UniProtKB/TrEMBL
  ENSRNOT00000115275.1 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Transferase(Phosphotransferase) domain 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro FN3_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FN3_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig-like_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig_I-set UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig_sub UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig_sub2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kinase-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:363256 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene Speg ENTREZGENE
PANTHER IG-LIKE DOMAIN-CONTAINING PROTEIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IMMUNOGLOBULIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR47633:SF3 UniProtKB/TrEMBL
Pfam I-set UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pkinase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SPEG_u2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Speg PhenoGen
PROSITE FN3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IG_LIKE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_ATP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000019850 RatGTEx
SMART FN3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IGc2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  S_TKc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SM00409 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF48726 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF49265 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF56112 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC229735
UniProt A0A8I5ZN28 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6ADG2 ENTREZGENE, UniProtKB/TrEMBL
  A0A8L2QUK8 ENTREZGENE, UniProtKB/TrEMBL
  A6JW28 ENTREZGENE, UniProtKB/TrEMBL
  A6JW29 ENTREZGENE, UniProtKB/TrEMBL
  Q63638 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2018-10-30 Speg  striated muscle enriched protein kinase  Speg  SPEG complex locus  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-03 Speg  SPEG complex locus  LOC363256  similar to aortic preferentially expressed gene 1  Data merged from RGD:1592053 737654 APPROVED
2008-03-12 Speg  SPEG complex locus  Apeg1  aortic preferentially expressed gene 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-11-20 LOC363256  similar to aortic preferentially expressed gene 1      Symbol and Name status set to provisional 70820 PROVISIONAL
2002-06-10 Apeg1  Aortic preferentially expressed gene 1      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_process may play a role in aortic smooth muscle cell differentiation 634650
gene_regulation expression is induced in response to vascular injury 634650