Speg (striated muscle enriched protein kinase) - Rat Genome Database

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Pathways
Gene: Speg (striated muscle enriched protein kinase) Rattus norvegicus
Analyze
Symbol: Speg
Name: striated muscle enriched protein kinase
RGD ID: 2124
Description: Predicted to enable protein kinase activity. Involved in muscle cell differentiation. Predicted to be located in nucleus. Human ortholog(s) of this gene implicated in centronuclear myopathy 5. Orthologous to human SPEG (striated muscle enriched protein kinase); INTERACTS WITH 17alpha-ethynylestradiol; acetamide; ammonium chloride.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: aortic preferentially expressed gene 1; aortic preferentially expressed protein 1; APEG-1; Apeg1; LOC363256; similar to aortic preferentially expressed gene 1; SPEG complex locus; striated muscle-specific serine/threonine-protein kinase
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8984,314,387 - 84,371,816 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl984,314,387 - 84,371,813 (+)EnsemblGRCr8
mRatBN7.2976,865,714 - 76,923,170 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl976,865,754 - 76,923,144 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx985,310,241 - 85,367,619 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0990,439,123 - 90,496,499 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0988,825,304 - 88,882,675 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0982,571,333 - 82,628,684 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl982,571,269 - 82,628,709 (+)Ensemblrn6Rnor6.0
Rnor_5.0982,340,581 - 82,397,945 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4974,652,526 - 74,709,904 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera974,435,692 - 74,492,957 (+)NCBICelera
RGSC_v3.1974,824,554 - 74,828,988 (+)NCBI
Cytogenetic Map9q33NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2-palmitoylglycerol  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
acetamide  (EXP)
acrylamide  (ISO)
aflatoxin B1  (ISO)
ammonium chloride  (EXP)
aniline  (EXP)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
atrazine  (EXP)
benzo[a]pyrene  (ISO)
benzo[e]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP)
bisphenol F  (ISO)
cadmium atom  (EXP)
cadmium dichloride  (EXP)
cantharidin  (ISO)
carbon nanotube  (ISO)
carmustine  (ISO)
chlordecone  (ISO)
chlorpyrifos  (ISO)
choline  (ISO)
cisplatin  (ISO)
clofibrate  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
copper(II) sulfate  (ISO)
coumarin  (ISO)
Cuprizon  (EXP)
diarsenic trioxide  (ISO)
dimethylarsinic acid  (EXP)
doxorubicin  (ISO)
endosulfan  (EXP)
entinostat  (ISO)
ethanol  (ISO)
flavonoids  (EXP)
folic acid  (ISO)
FR900359  (ISO)
fulvestrant  (ISO)
gentamycin  (EXP)
haloperidol  (ISO)
hydrogen peroxide  (ISO)
L-methionine  (ISO)
linsidomine  (EXP)
methamphetamine  (ISO)
methapyrilene  (ISO)
Muraglitazar  (EXP)
N-ethyl-N-nitrosourea  (ISO)
nitrofen  (EXP)
ozone  (EXP)
paracetamol  (EXP,ISO)
pioglitazone  (ISO)
progesterone  (EXP)
resveratrol  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
Soman  (EXP)
Tesaglitazar  (EXP)
thioacetamide  (EXP)
titanium dioxide  (ISO)
triptonide  (ISO)
troglitazone  (EXP)
valproic acid  (EXP)
vinclozolin  (EXP)
vitamin E  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
nucleus  (IEA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. APEG-1, a novel gene preferentially expressed in aortic smooth muscle cells, is down-regulated by vascular injury. Hsieh CM, etal., J Biol Chem 1996 Jul 19;271(29):17354-9.
3. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
4. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
6. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
Additional References at PubMed
PMID:10973969   PMID:12477932   PMID:15057822   PMID:19118250   PMID:31790338  


Genomics

Comparative Map Data
Speg
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8984,314,387 - 84,371,816 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl984,314,387 - 84,371,813 (+)EnsemblGRCr8
mRatBN7.2976,865,714 - 76,923,170 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl976,865,754 - 76,923,144 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx985,310,241 - 85,367,619 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0990,439,123 - 90,496,499 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0988,825,304 - 88,882,675 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0982,571,333 - 82,628,684 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl982,571,269 - 82,628,709 (+)Ensemblrn6Rnor6.0
Rnor_5.0982,340,581 - 82,397,945 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4974,652,526 - 74,709,904 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera974,435,692 - 74,492,957 (+)NCBICelera
RGSC_v3.1974,824,554 - 74,828,988 (+)NCBI
Cytogenetic Map9q33NCBI
SPEG
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382219,434,843 - 219,493,629 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2219,434,843 - 219,493,629 (+)Ensemblhg38GRCh38
GRCh372220,299,565 - 220,358,351 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362220,007,944 - 220,066,598 (+)NCBIBuild 36Build 36hg18NCBI36
Build 342220,133,900 - 220,157,088NCBI
Celera2214,069,692 - 214,128,346 (+)NCBICelera
Cytogenetic Map2q35NCBI
HuRef2212,152,724 - 212,211,419 (+)NCBIHuRef
CHM1_12220,305,523 - 220,364,193 (+)NCBICHM1_1
T2T-CHM13v2.02219,919,623 - 219,978,369 (+)NCBIT2T-CHM13v2.0
Speg
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39175,351,931 - 75,408,964 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl175,351,941 - 75,408,964 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38175,375,297 - 75,432,320 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl175,375,297 - 75,432,320 (+)Ensemblmm10GRCm38
MGSCv37175,371,872 - 75,428,889 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36175,258,445 - 75,315,462 (+)NCBIMGSCv36mm8
Celera175,865,860 - 75,923,244 (+)NCBICelera
Cytogenetic Map1C4NCBI
cM Map138.88NCBI
Speg
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545313,976,674 - 14,033,252 (-)Ensembl
ChiLan1.0NW_00495545313,979,080 - 14,033,718 (-)NCBIChiLan1.0ChiLan1.0
SPEG
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v213122,065,106 - 122,123,484 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12B122,080,072 - 122,138,450 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B106,692,222 - 106,750,922 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B225,282,554 - 225,340,753 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B225,282,676 - 225,339,910 (+)EnsemblpanPan2panpan1.1
SPEG
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13725,947,605 - 26,005,601 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3725,947,773 - 26,005,601 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha3726,773,599 - 26,831,117 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.03725,963,015 - 26,020,671 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3725,963,015 - 26,020,671 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13725,866,874 - 25,924,631 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03725,802,876 - 25,860,720 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03725,823,459 - 25,881,304 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Speg
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303175,484,247 - 175,534,225 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365691,821,143 - 1,876,156 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365691,821,125 - 1,877,006 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SPEG
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.115121,443,976 - 121,501,453 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.215134,640,604 - 134,688,490 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SPEG
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.110105,330,171 - 105,388,657 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl10105,330,171 - 105,387,810 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604094,012,325 - 94,070,649 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Speg
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248235,564,550 - 5,618,786 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248235,563,687 - 5,618,786 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Speg
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v14148,734,131 - 148,783,892 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Speg
424 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:350
Count of miRNA genes:190
Interacting mature miRNAs:242
Transcripts:ENSRNOT00000026941, ENSRNOT00000065076
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2303170Bp332Blood pressure QTL 3323.730.027arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)9671488884474983Rat
631656Bp108Blood pressure QTL 1085.970.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)956047863101047863Rat
7411571Bw138Body weight QTL 13814.30.001body mass (VT:0001259)body weight gain (CMO:0000420)94002992585029925Rat
1582203Gluco19Glucose level QTL 193.30.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)963376862108376862Rat
8662828Vetf6Vascular elastic tissue fragility QTL 63.9artery integrity trait (VT:0010639)patent ductus arteriosus score (CMO:0002566)94445825699506504Rat
724515Uae16Urinary albumin excretion QTL 168urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)965657365108376720Rat
61352Bp34Blood pressure QTL 345arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)98216882386720295Rat
1598834Memor11Memory QTL 112.5exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)94445825685262605Rat
70218Cm28Cardiac mass QTL 288.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)94172029586720295Rat
724544Uae9Urinary albumin excretion QTL 94.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)964220169109220169Rat
2290450Scl57Serum cholesterol level QTL 574.15blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)944458256121768150Rat
1578760Cm53Cardiac mass QTL 533.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)964220169109220169Rat
1581580Uae34Urinary albumin excretion QTL 34urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)964220169109220169Rat
1300134Bp185Blood pressure QTL 1853.73arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)968875497121768150Rat
1354626Bvd1Brain ventricular dilatation QTL 13.730.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)983161999118999486Rat
731164Uae25Urinary albumin excretion QTL 253.50.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)948718864108376862Rat
7411656Foco26Food consumption QTL 269.80.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)94002992585029925Rat
4889943Bss90Bone structure and strength QTL 904.1tibia area (VT:1000281)tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)95450650499506504Rat
1578757Pur6Proteinuria QTL 63.30.005urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)964220169109220169Rat

Markers in Region
D9Rat8  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8984,351,602 - 84,351,733 (+)Marker Load Pipeline
mRatBN7.2976,902,954 - 76,903,085 (+)MAPPERmRatBN7.2
Rnor_6.0982,608,497 - 82,608,627NCBIRnor6.0
Rnor_5.0982,377,758 - 82,377,888UniSTSRnor5.0
RGSC_v3.4974,689,717 - 74,689,847UniSTSRGSC3.4
RGSC_v3.4974,689,716 - 74,689,847RGDRGSC3.4
Celera974,472,770 - 74,472,900UniSTS
RGSC_v3.1974,836,699 - 74,836,829RGD
RH 3.4 Map9774.2RGD
RH 3.4 Map9774.2UniSTS
SHRSP x BN Map951.1998UniSTS
SHRSP x BN Map951.1998RGD
Cytogenetic Map9q33UniSTS
D9Mco71  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2976,874,236 - 76,874,409 (+)MAPPERmRatBN7.2
Rnor_6.0982,579,829 - 82,580,001NCBIRnor6.0
Rnor_5.0982,349,090 - 82,349,262UniSTSRnor5.0
RGSC_v3.4974,661,010 - 74,661,182UniSTSRGSC3.4
Celera974,444,176 - 74,444,348UniSTS
Cytogenetic Map9q33UniSTS
U57098  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2976,894,867 - 76,894,951 (+)MAPPERmRatBN7.2
Rnor_6.0982,600,459 - 82,600,542NCBIRnor6.0
Rnor_5.0982,369,720 - 82,369,803UniSTSRnor5.0
RGSC_v3.4974,681,640 - 74,681,723UniSTSRGSC3.4
Celera974,464,804 - 74,464,887UniSTS
Cytogenetic Map9q33UniSTS
RH128701  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2976,895,074 - 76,895,229 (+)MAPPERmRatBN7.2
Rnor_6.0982,600,666 - 82,600,820NCBIRnor6.0
Rnor_5.0982,369,927 - 82,370,081UniSTSRnor5.0
RGSC_v3.4974,681,847 - 74,682,001UniSTSRGSC3.4
Celera974,465,011 - 74,465,165UniSTS
RH 3.4 Map9711.39UniSTS
Cytogenetic Map9q33UniSTS
BE098213  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2976,922,385 - 76,922,552 (+)MAPPERmRatBN7.2
Rnor_6.0982,627,926 - 82,628,092NCBIRnor6.0
Rnor_5.0982,397,187 - 82,397,353UniSTSRnor5.0
RGSC_v3.4974,709,146 - 74,709,312UniSTSRGSC3.4
Celera974,492,199 - 74,492,365UniSTS
RH 3.4 Map9757.79UniSTS
Cytogenetic Map9q33UniSTS
RH139048  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2976,873,926 - 76,874,070 (+)MAPPERmRatBN7.2
Rnor_6.0982,579,519 - 82,579,662NCBIRnor6.0
Rnor_5.0982,348,780 - 82,348,923UniSTSRnor5.0
RGSC_v3.4974,660,700 - 74,660,843UniSTSRGSC3.4
Celera974,443,866 - 74,444,009UniSTS
RH 3.4 Map9757.29UniSTS
Cytogenetic Map9q33UniSTS
D1Bwg1450e  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2976,922,880 - 76,923,057 (+)MAPPERmRatBN7.2
Rnor_6.0982,628,421 - 82,628,597NCBIRnor6.0
Rnor_5.0982,397,682 - 82,397,858UniSTSRnor5.0
RGSC_v3.4974,709,641 - 74,709,817UniSTSRGSC3.4
Celera974,492,694 - 74,492,870UniSTS
Cytogenetic Map9q33UniSTS
REN52878  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2976,878,241 - 76,878,464 (+)MAPPERmRatBN7.2
Rnor_6.0982,583,834 - 82,584,056NCBIRnor6.0
Rnor_5.0982,353,095 - 82,353,317UniSTSRnor5.0
RGSC_v3.4974,665,015 - 74,665,237UniSTSRGSC3.4
Celera974,448,181 - 74,448,403UniSTS
Cytogenetic Map9q33UniSTS
REN53031  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2976,912,843 - 76,913,078 (+)MAPPERmRatBN7.2
Rnor_6.0982,618,386 - 82,618,620NCBIRnor6.0
Rnor_5.0982,387,647 - 82,387,881UniSTSRnor5.0
RGSC_v3.4974,699,606 - 74,699,840UniSTSRGSC3.4
Celera974,482,659 - 74,482,893UniSTS
Cytogenetic Map9q33UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 162 91 90 59 90 59 6 351 190 11 138 78 92 31 17 17

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001108802 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_012905 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006245252 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006245255 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006245256 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008767267 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008767268 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008767269 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008767270 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008767271 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017596526 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017596527 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017596528 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017596529 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039083887 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039083888 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039083890 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039083892 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039083893 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063267412 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063267413 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063267414 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063267415 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063267416 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063267417 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063267418 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063267419 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC112361 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC087690 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH474004 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EV763588 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000009 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U57097 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000026941   ⟹   ENSRNOP00000026941
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl984,314,387 - 84,371,813 (+)Ensembl
mRatBN7.2 Ensembl976,865,754 - 76,923,144 (+)Ensembl
Rnor_6.0 Ensembl982,571,269 - 82,628,709 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000065076   ⟹   ENSRNOP00000063082
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl976,890,719 - 76,895,230 (+)Ensembl
Rnor_6.0 Ensembl982,596,355 - 82,600,826 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000098450   ⟹   ENSRNOP00000084140
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl984,321,322 - 84,343,882 (+)Ensembl
mRatBN7.2 Ensembl976,872,686 - 76,895,232 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000114940   ⟹   ENSRNOP00000091308
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl984,314,387 - 84,371,813 (+)Ensembl
mRatBN7.2 Ensembl976,865,754 - 76,923,144 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000115275   ⟹   ENSRNOP00000079646
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl984,321,322 - 84,343,882 (+)Ensembl
mRatBN7.2 Ensembl976,872,686 - 76,895,232 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000122671   ⟹   ENSRNOP00000105531
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl984,321,322 - 84,371,813 (+)Ensembl
RefSeq Acc Id: NM_001108802   ⟹   NP_001102272
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8984,314,387 - 84,371,813 (+)NCBI
mRatBN7.2976,865,738 - 76,923,167 (+)NCBI
Rnor_6.0982,571,345 - 82,628,684 (+)NCBI
Rnor_5.0982,340,581 - 82,397,945 (+)NCBI
RGSC_v3.4974,652,526 - 74,709,904 (+)RGD
Celera974,435,692 - 74,492,957 (+)RGD
Sequence:
RefSeq Acc Id: NM_012905   ⟹   NP_037037
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8984,339,412 - 84,343,883 (+)NCBI
mRatBN7.2976,890,763 - 76,895,235 (+)NCBI
Rnor_6.0982,596,355 - 82,600,826 (+)NCBI
Rnor_5.0982,340,581 - 82,397,945 (+)NCBI
Celera974,460,700 - 74,465,171 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006245252   ⟹   XP_006245314
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8984,320,978 - 84,371,816 (+)NCBI
mRatBN7.2976,872,319 - 76,923,170 (+)NCBI
Rnor_6.0982,577,890 - 82,628,280 (+)NCBI
Rnor_5.0982,340,581 - 82,397,945 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006245255   ⟹   XP_006245317
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8984,330,970 - 84,371,816 (+)NCBI
mRatBN7.2976,888,438 - 76,923,170 (+)NCBI
Rnor_6.0982,594,065 - 82,628,280 (+)NCBI
Rnor_5.0982,340,581 - 82,397,945 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006245256   ⟹   XP_006245318
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8984,339,572 - 84,371,816 (+)NCBI
mRatBN7.2976,890,917 - 76,923,170 (+)NCBI
Rnor_6.0982,596,456 - 82,628,280 (+)NCBI
Rnor_5.0982,340,581 - 82,397,945 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017596526   ⟹   XP_017452015
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8984,321,265 - 84,371,816 (+)NCBI
mRatBN7.2976,872,616 - 76,923,170 (+)NCBI
Rnor_6.0982,578,257 - 82,628,280 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017596527   ⟹   XP_017452016
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8984,321,284 - 84,371,816 (+)NCBI
mRatBN7.2976,872,587 - 76,923,170 (+)NCBI
Rnor_6.0982,578,225 - 82,628,280 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017596528   ⟹   XP_017452017
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8984,324,714 - 84,371,816 (+)NCBI
mRatBN7.2976,876,064 - 76,923,170 (+)NCBI
Rnor_6.0982,581,641 - 82,628,280 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017596529   ⟹   XP_017452018
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8984,324,388 - 84,371,816 (+)NCBI
mRatBN7.2976,875,739 - 76,923,170 (+)NCBI
Rnor_6.0982,581,756 - 82,628,280 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039083887   ⟹   XP_038939815
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8984,314,398 - 84,371,816 (+)NCBI
mRatBN7.2976,865,726 - 76,923,170 (+)NCBI
RefSeq Acc Id: XM_039083888   ⟹   XP_038939816
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8984,314,398 - 84,371,816 (+)NCBI
mRatBN7.2976,865,726 - 76,923,170 (+)NCBI
RefSeq Acc Id: XM_039083890   ⟹   XP_038939818
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8984,324,275 - 84,371,816 (+)NCBI
mRatBN7.2976,875,611 - 76,923,170 (+)NCBI
RefSeq Acc Id: XM_039083892   ⟹   XP_038939820
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8984,314,398 - 84,343,883 (+)NCBI
mRatBN7.2976,865,714 - 76,895,236 (+)NCBI
RefSeq Acc Id: XM_039083893   ⟹   XP_038939821
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8984,314,398 - 84,343,883 (+)NCBI
mRatBN7.2976,865,717 - 76,895,236 (+)NCBI
RefSeq Acc Id: XM_063267412   ⟹   XP_063123482
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8984,314,398 - 84,371,816 (+)NCBI
RefSeq Acc Id: XM_063267413   ⟹   XP_063123483
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8984,324,734 - 84,371,816 (+)NCBI
RefSeq Acc Id: XM_063267414   ⟹   XP_063123484
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8984,321,240 - 84,343,883 (+)NCBI
RefSeq Acc Id: XM_063267415   ⟹   XP_063123485
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8984,314,398 - 84,343,883 (+)NCBI
RefSeq Acc Id: XM_063267416   ⟹   XP_063123486
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8984,314,393 - 84,343,883 (+)NCBI
RefSeq Acc Id: XM_063267417   ⟹   XP_063123487
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8984,320,971 - 84,343,883 (+)NCBI
RefSeq Acc Id: XM_063267418   ⟹   XP_063123488
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8984,321,247 - 84,343,883 (+)NCBI
RefSeq Acc Id: XM_063267419   ⟹   XP_063123489
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8984,321,252 - 84,343,883 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001102272 (Get FASTA)   NCBI Sequence Viewer  
  NP_037037 (Get FASTA)   NCBI Sequence Viewer  
  XP_006245314 (Get FASTA)   NCBI Sequence Viewer  
  XP_006245317 (Get FASTA)   NCBI Sequence Viewer  
  XP_006245318 (Get FASTA)   NCBI Sequence Viewer  
  XP_017452015 (Get FASTA)   NCBI Sequence Viewer  
  XP_017452016 (Get FASTA)   NCBI Sequence Viewer  
  XP_017452017 (Get FASTA)   NCBI Sequence Viewer  
  XP_017452018 (Get FASTA)   NCBI Sequence Viewer  
  XP_038939815 (Get FASTA)   NCBI Sequence Viewer  
  XP_038939816 (Get FASTA)   NCBI Sequence Viewer  
  XP_038939818 (Get FASTA)   NCBI Sequence Viewer  
  XP_038939820 (Get FASTA)   NCBI Sequence Viewer  
  XP_038939821 (Get FASTA)   NCBI Sequence Viewer  
  XP_063123482 (Get FASTA)   NCBI Sequence Viewer  
  XP_063123483 (Get FASTA)   NCBI Sequence Viewer  
  XP_063123484 (Get FASTA)   NCBI Sequence Viewer  
  XP_063123485 (Get FASTA)   NCBI Sequence Viewer  
  XP_063123486 (Get FASTA)   NCBI Sequence Viewer  
  XP_063123487 (Get FASTA)   NCBI Sequence Viewer  
  XP_063123488 (Get FASTA)   NCBI Sequence Viewer  
  XP_063123489 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAC52667 (Get FASTA)   NCBI Sequence Viewer  
  EDL75436 (Get FASTA)   NCBI Sequence Viewer  
  EDL75437 (Get FASTA)   NCBI Sequence Viewer  
  EDL75438 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000026941
  ENSRNOP00000026941.4
  ENSRNOP00000084140
  ENSRNOP00000084140.1
  ENSRNOP00000105531
GenBank Protein Q63638 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001102272   ⟸   NM_001108802
- Peptide Label: isoform 1
- UniProtKB: Q63638 (UniProtKB/Swiss-Prot),   A0A8I6ADG2 (UniProtKB/TrEMBL),   A6JW28 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_037037   ⟸   NM_012905
- Peptide Label: isoform 4
- UniProtKB: A0A8L2QUK8 (UniProtKB/TrEMBL),   A6JW29 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006245314   ⟸   XM_006245252
- Peptide Label: isoform X6
- Sequence:
RefSeq Acc Id: XP_006245317   ⟸   XM_006245255
- Peptide Label: isoform X7
- Sequence:
RefSeq Acc Id: XP_006245318   ⟸   XM_006245256
- Peptide Label: isoform X7
- Sequence:
RefSeq Acc Id: XP_017452016   ⟸   XM_017596527
- Peptide Label: isoform X5
- UniProtKB: A0A8I6ADG2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017452015   ⟸   XM_017596526
- Peptide Label: isoform X4
- UniProtKB: A0A8I6ADG2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017452017   ⟸   XM_017596528
- Peptide Label: isoform X6
- Sequence:
RefSeq Acc Id: XP_017452018   ⟸   XM_017596529
- Peptide Label: isoform X6
- Sequence:
Ensembl Acc Id: ENSRNOP00000063082   ⟸   ENSRNOT00000065076
Ensembl Acc Id: ENSRNOP00000026941   ⟸   ENSRNOT00000026941
RefSeq Acc Id: XP_038939820   ⟸   XM_039083892
- Peptide Label: isoform X8
RefSeq Acc Id: XP_038939821   ⟸   XM_039083893
- Peptide Label: isoform X9
- UniProtKB: A0A8I5ZN28 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038939815   ⟸   XM_039083887
- Peptide Label: isoform X1
- UniProtKB: A0A8I6ADG2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038939816   ⟸   XM_039083888
- Peptide Label: isoform X3
- UniProtKB: A0A8I6ADG2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038939818   ⟸   XM_039083890
- Peptide Label: isoform X6
Ensembl Acc Id: ENSRNOP00000079646   ⟸   ENSRNOT00000115275
Ensembl Acc Id: ENSRNOP00000084140   ⟸   ENSRNOT00000098450
Ensembl Acc Id: ENSRNOP00000091308   ⟸   ENSRNOT00000114940
RefSeq Acc Id: XP_063123486   ⟸   XM_063267416
- Peptide Label: isoform X12
- UniProtKB: A0A8I5ZN28 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063123482   ⟸   XM_063267412
- Peptide Label: isoform X2
- UniProtKB: A0A8I6ADG2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063123485   ⟸   XM_063267415
- Peptide Label: isoform X11
- UniProtKB: A0A8I5ZN28 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063123487   ⟸   XM_063267417
- Peptide Label: isoform X13
RefSeq Acc Id: XP_063123484   ⟸   XM_063267414
- Peptide Label: isoform X10
- UniProtKB: A0A8I5ZN28 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063123488   ⟸   XM_063267418
- Peptide Label: isoform X14
- UniProtKB: A0A8I5ZN28 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063123489   ⟸   XM_063267419
- Peptide Label: isoform X15
- UniProtKB: A0A8I5ZN28 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063123483   ⟸   XM_063267413
- Peptide Label: isoform X6
Ensembl Acc Id: ENSRNOP00000105531   ⟸   ENSRNOT00000122671
Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2124 AgrOrtholog
BioCyc Gene G2FUF-27073 BioCyc
Ensembl Genes ENSRNOG00000019850 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000026941 ENTREZGENE
  ENSRNOT00000026941.8 UniProtKB/Swiss-Prot
  ENSRNOT00000098450 ENTREZGENE
  ENSRNOT00000098450.1 UniProtKB/Swiss-Prot
  ENSRNOT00000122671 ENTREZGENE
Gene3D-CATH 2.60.40.10 UniProtKB/Swiss-Prot
  Phosphorylase Kinase, domain 1 UniProtKB/Swiss-Prot
  Transferase(Phosphotransferase) domain 1 UniProtKB/Swiss-Prot
InterPro FN3_dom UniProtKB/Swiss-Prot
  FN3_sf UniProtKB/Swiss-Prot
  Ig-like_dom UniProtKB/Swiss-Prot
  Ig-like_dom_sf UniProtKB/Swiss-Prot
  Ig-like_fold UniProtKB/Swiss-Prot
  Ig_I-set UniProtKB/Swiss-Prot
  Ig_sub UniProtKB/Swiss-Prot
  Ig_sub2 UniProtKB/Swiss-Prot
  Kinase-like_dom_sf UniProtKB/Swiss-Prot
  Prot_kinase_dom UniProtKB/Swiss-Prot
  Protein_kinase_ATP_BS UniProtKB/Swiss-Prot
  Ser/Thr_kinase_AS UniProtKB/Swiss-Prot
KEGG Report rno:363256 UniProtKB/Swiss-Prot
NCBI Gene Speg ENTREZGENE
PANTHER IMMUNOGLOBULIN UniProtKB/Swiss-Prot
  STRIATED MUSCLE PREFERENTIALLY EXPRESSED PROTEIN KINASE UniProtKB/Swiss-Prot
Pfam I-set UniProtKB/Swiss-Prot
  Pkinase UniProtKB/Swiss-Prot
  SPEG_u2 UniProtKB/Swiss-Prot
PhenoGen Speg PhenoGen
PROSITE FN3 UniProtKB/Swiss-Prot
  IG_LIKE UniProtKB/Swiss-Prot
  PROTEIN_KINASE_ATP UniProtKB/Swiss-Prot
  PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot
  PROTEIN_KINASE_ST UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000019850 RatGTEx
SMART FN3 UniProtKB/Swiss-Prot
  IGc2 UniProtKB/Swiss-Prot
  S_TKc UniProtKB/Swiss-Prot
  SM00409 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF48726 UniProtKB/Swiss-Prot
  SSF49265 UniProtKB/Swiss-Prot
  SSF56112 UniProtKB/Swiss-Prot
TIGR TC229735
UniProt A0A8I5ZN28 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6ADG2 ENTREZGENE, UniProtKB/TrEMBL
  A0A8L2QUK8 ENTREZGENE
  A0ABK0LV53_RAT UniProtKB/TrEMBL
  A6JW28 ENTREZGENE, UniProtKB/TrEMBL
  A6JW29 ENTREZGENE, UniProtKB/TrEMBL
  Q63638 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2018-10-30 Speg  striated muscle enriched protein kinase  Speg  SPEG complex locus  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-03 Speg  SPEG complex locus  LOC363256  similar to aortic preferentially expressed gene 1  Data merged from RGD:1592053 737654 APPROVED
2008-03-12 Speg  SPEG complex locus  Apeg1  aortic preferentially expressed gene 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-11-20 LOC363256  similar to aortic preferentially expressed gene 1      Symbol and Name status set to provisional 70820 PROVISIONAL
2002-06-10 Apeg1  Aortic preferentially expressed gene 1      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_process may play a role in aortic smooth muscle cell differentiation 634650
gene_regulation expression is induced in response to vascular injury 634650