Anxa3 (annexin A3) - Rat Genome Database

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Gene: Anxa3 (annexin A3) Rattus norvegicus
Analyze
Symbol: Anxa3
Name: annexin A3
RGD ID: 2119
Description: Enables calcium-dependent phospholipid binding activity and phospholipase A2 inhibitor activity. Involved in several processes, including animal organ regeneration; hippocampus development; and response to glucocorticoid. Located in axon; dendrite; and neuronal cell body. Biomarker of glaucoma. Orthologous to human ANXA3 (annexin A3); INTERACTS WITH 1,2-dimethylhydrazine; 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 35-alpha calcimedin; Annexin III (Lipocortin III); annexin-3; Anx3; LC3; lipocortin III; LRRGT00047; PAP-III; placental anticoagulant protein III
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81413,031,675 - 13,085,678 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1413,023,762 - 13,085,849 (-)EnsemblGRCr8
mRatBN7.21412,727,708 - 12,781,717 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1412,719,795 - 12,781,617 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1412,696,058 - 12,750,404 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01413,995,901 - 14,050,256 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01412,712,209 - 12,766,711 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01414,371,921 - 14,426,503 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1414,364,008 - 14,426,437 (-)Ensemblrn6Rnor6.0
Rnor_5.01414,313,646 - 14,368,216 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41414,245,112 - 14,297,100 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1412,785,419 - 12,839,165 (-)NCBICelera
RGSC_v3.11414,245,111 - 14,297,100 (-)NCBI
RH 3.4 Map14155.77RGD
Cytogenetic Map14p22NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,1-dichloroethene  (ISO)
1,2-dimethylhydrazine  (EXP,ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,2,2-tetramine  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,4-dinitrotoluene  (EXP)
2,6-dimethoxyphenol  (ISO)
2-acetamidofluorene  (EXP,ISO)
2-hydroxypropanoic acid  (ISO)
2-methoxyethanol  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-fluorouracil  (ISO)
acetamide  (EXP)
aflatoxin B1  (EXP,ISO)
all-trans-retinoic acid  (ISO)
alpha-Zearalanol  (EXP)
ammonium chloride  (EXP)
aniline  (EXP)
Aroclor 1254  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
asbestos  (ISO)
benzene  (ISO)
benzene-1,2,4-triol  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
Benzo[k]fluoranthene  (ISO)
beta-lapachone  (ISO)
bexarotene  (EXP)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bleomycin A2  (EXP)
Brodifacoum  (EXP)
buspirone  (EXP)
butanal  (ISO)
Butylbenzyl phthalate  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
calcitriol  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
carbonyl sulfide  (EXP)
CGP 52608  (ISO)
chloropicrin  (ISO)
choline  (ISO)
cisplatin  (ISO)
cobalt dichloride  (EXP,ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
coumestrol  (ISO)
crocidolite asbestos  (ISO)
Cuprizon  (EXP)
cyclosporin A  (ISO)
desferrioxamine B  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
diazinon  (EXP)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (EXP,ISO)
dichlorine  (EXP)
diethyl maleate  (EXP)
diethylstilbestrol  (ISO)
dioxygen  (ISO)
dopamine  (ISO)
dorsomorphin  (ISO)
drometrizole  (ISO)
endosulfan  (EXP)
Enterolactone  (ISO)
ethanol  (EXP,ISO)
fenamidone  (ISO)
fenofibrate  (EXP)
ferric ammonium citrate  (ISO)
ferric oxide  (ISO)
flurbiprofen  (ISO)
flutamide  (EXP)
folic acid  (ISO)
formaldehyde  (ISO)
furfural  (ISO)
genistein  (ISO)
gentamycin  (EXP)
graphite  (EXP)
griseofulvin  (ISO)
hyaluronic acid  (EXP)
hydrogen peroxide  (EXP)
hydroquinone  (ISO)
ibuprofen  (ISO)
indometacin  (ISO)
inulin  (ISO)
ivermectin  (ISO)
ketamine  (EXP)
L-methionine  (ISO)
leflunomide  (ISO)
lipopolysaccharide  (ISO)
lithocholic acid  (ISO)
lucanthone  (ISO)
manganese(II) chloride  (EXP)
mercury dibromide  (ISO)
methamphetamine  (EXP)
methylmercury chloride  (ISO)
mifepristone  (EXP)
mono(2-ethylhexyl) phthalate  (ISO)
monobenzyl phthalate  (ISO)
Monobutylphthalate  (ISO)
monoethyl phthalate  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
N-nitrosodimethylamine  (EXP)
N-nitrosomorpholine  (EXP)
nefazodone  (EXP)
nickel sulfate  (ISO)
nimesulide  (EXP)
Nonylphenol  (EXP)
O-methyleugenol  (ISO)
ochratoxin A  (EXP,ISO)
oxaliplatin  (EXP)
oxycodone  (EXP)
ozone  (EXP,ISO)
p-chloromercuribenzoic acid  (ISO)
panobinostat  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP)
PCB138  (EXP)
pentanal  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP)
phenobarbital  (ISO)
phenol red  (ISO)
phenylmercury acetate  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
pirinixic acid  (EXP,ISO)
potassium chromate  (ISO)
potassium dichromate  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP,ISO)
progesterone  (ISO)
quercetin  (ISO)
rac-lactic acid  (ISO)
resveratrol  (EXP,ISO)
rofecoxib  (ISO)
rotenone  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
simvastatin  (ISO)
sodium arsenite  (ISO)
sodium chloride  (ISO)
sodium fluoride  (ISO)
Soman  (EXP)
streptozocin  (EXP)
sunitinib  (ISO)
tamoxifen  (EXP,ISO)
temozolomide  (ISO)
testosterone  (EXP,ISO)
tetrachloromethane  (EXP,ISO)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (EXP,ISO)
triadimefon  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
triphenyl phosphate  (EXP,ISO)
tris(2-butoxyethyl) phosphate  (ISO)
troglitazone  (EXP)
tunicamycin  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vancomycin  (ISO)
vinclozolin  (EXP)
vorinostat  (ISO)
zearalenone  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Change in annexin A3 expression by regulatory factors of hepatocyte growth in primary cultured rat hepatocytes. Harashima M, etal., Biol Pharm Bull. 2006 Jul;29(7):1339-43.
4. Annexin A3 expression increases in hepatocytes and is regulated by hepatocyte growth factor in rat liver regeneration. Harashima M, etal., J Biochem. 2008 Apr;143(4):537-45. Epub 2008 Jan 7.
5. High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
6. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
7. Differential expression of annexins I-VI in the rat dorsal root ganglia and spinal cord. Naciff JM, etal., J Comp Neurol. 1996 May 6;368(3):356-70.
8. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
9. Expression of annexin A3 in primary cultured parenchymal rat hepatocytes and inhibition of DNA synthesis by suppression of annexin A3 expression using RNA interference. Niimi S, etal., Biol Pharm Bull. 2005 Mar;28(3):424-8.
10. Five distinct calcium and phospholipid binding proteins share homology with lipocortin I. Pepinsky RB, etal., J Biol Chem 1988 Aug 5;263(22):10799-811.
11. GOA pipeline RGD automated data pipeline
12. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
13. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
14. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
15. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
16. Changes of hippocampal signaling protein levels during postnatal brain development in the rat. Weitzdorfer R, etal., Hippocampus. 2008;18(8):807-13.
17. Changes in gene expression in experimental glaucoma and optic nerve transection: the equilibrium between protective and detrimental mechanisms. Yang Z, etal., Invest Ophthalmol Vis Sci. 2007 Dec;48(12):5539-48.
Additional References at PubMed
PMID:2138016   PMID:2138632   PMID:7526843   PMID:9497492   PMID:9550422   PMID:15226301   PMID:15489334   PMID:16236264   PMID:16506224   PMID:17205602   PMID:17330750   PMID:17617739  
PMID:18273499   PMID:19056867   PMID:21243749   PMID:22328594   PMID:23376485   PMID:23533145   PMID:25200811   PMID:30456911   PMID:33167086   PMID:33779883   PMID:34221002   PMID:35118791  


Genomics

Comparative Map Data
Anxa3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81413,031,675 - 13,085,678 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1413,023,762 - 13,085,849 (-)EnsemblGRCr8
mRatBN7.21412,727,708 - 12,781,717 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1412,719,795 - 12,781,617 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1412,696,058 - 12,750,404 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01413,995,901 - 14,050,256 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01412,712,209 - 12,766,711 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01414,371,921 - 14,426,503 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1414,364,008 - 14,426,437 (-)Ensemblrn6Rnor6.0
Rnor_5.01414,313,646 - 14,368,216 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41414,245,112 - 14,297,100 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1412,785,419 - 12,839,165 (-)NCBICelera
RGSC_v3.11414,245,111 - 14,297,100 (-)NCBI
RH 3.4 Map14155.77RGD
Cytogenetic Map14p22NCBI
ANXA3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38478,551,770 - 78,610,447 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl478,551,621 - 78,610,493 (+)Ensemblhg38GRCh38
GRCh37479,472,924 - 79,531,601 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36479,691,766 - 79,750,629 (+)NCBIBuild 36Build 36hg18NCBI36
Build 34479,832,767 - 79,888,761NCBI
Celera476,768,779 - 76,827,650 (+)NCBICelera
Cytogenetic Map4q21.21NCBI
HuRef475,219,132 - 75,277,891 (+)NCBIHuRef
CHM1_1479,449,236 - 79,508,101 (+)NCBICHM1_1
T2T-CHM13v2.0481,887,335 - 81,946,029 (+)NCBIT2T-CHM13v2.0
Anxa3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39596,941,257 - 96,993,825 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl596,941,198 - 96,993,825 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38596,793,385 - 96,845,968 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl596,793,339 - 96,845,966 (+)Ensemblmm10GRCm38
MGSCv37597,222,404 - 97,274,987 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36597,033,717 - 97,086,270 (+)NCBIMGSCv36mm8
Celera594,124,314 - 94,176,695 (+)NCBICelera
Cytogenetic Map5E3NCBI
cM Map547.29NCBI
Anxa3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554332,977,513 - 3,044,446 (+)Ensembl
ChiLan1.0NW_0049554332,981,113 - 3,043,894 (+)NCBIChiLan1.0ChiLan1.0
ANXA3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2351,453,965 - 51,512,738 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1451,643,125 - 51,701,882 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0445,585,873 - 45,644,783 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1451,432,846 - 51,491,677 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl451,432,846 - 51,491,677 (-)EnsemblpanPan2panpan1.1
ANXA3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1323,006,000 - 3,049,321 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl323,005,788 - 3,049,049 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha3238,844,367 - 38,888,056 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0323,031,716 - 3,075,494 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl323,031,892 - 3,075,494 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1323,019,326 - 3,063,070 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0322,967,436 - 3,010,913 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03237,159,977 - 37,203,480 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Anxa3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244052859,290,753 - 9,353,506 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366762,153,689 - 2,216,627 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049366762,153,752 - 2,216,498 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ANXA3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1873,970,314 - 73,993,039 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2878,208,453 - 78,238,185 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ANXA3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1726,999,136 - 27,060,783 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl726,999,012 - 27,061,692 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_0236660375,382,730 - 5,444,583 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Anxa3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475712,442,577 - 12,502,903 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462475712,442,577 - 12,505,367 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Anxa3
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1117,419,275 - 7,458,042 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Anxa3
556 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:282
Count of miRNA genes:184
Interacting mature miRNAs:202
Transcripts:ENSRNOT00000046639, ENSRNOT00000068134
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300114Srn2Serum renin concentration QTL 23.27blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)14395787821572472Rat
2293089Iddm31Insulin dependent diabetes mellitus QTL 314.7blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)14395787818558812Rat
7411573Bw139Body weight QTL 1394.70.001body mass (VT:0001259)body weight gain (CMO:0000420)14140068101Rat
9589814Gluco67Glucose level QTL 674.540.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)14140068101Rat
731183Pia20Pristane induced arthritis QTL 203.55joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)14939329839411170Rat
631212Bw5Body weight QTL55.43retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)141133490630674469Rat
2302277Gluco38Glucose level QTL 385.8blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)141133471628389666Rat
1331740Bw26Body weight QTL 263.028body mass (VT:0001259)body weight (CMO:0000012)14395787831121464Rat
71117Niddm17Non-insulin dependent diabetes mellitus QTL 172.35blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)14117877928Rat
1358296Ael3Aortic elastin QTL 33.70.00051aorta elastin amount (VT:0003905)aortic elastin14862139853621398Rat
70195Mcs8Mammary carcinoma susceptibility QTL 84.28mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)14395787824886169Rat
631839Niddm37Non-insulin dependent diabetes mellitus QTL 373.37blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1411334716100078267Rat
634352Apr6Acute phase response QTL 63.7blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)14141415516Rat
70204Niddm20Non-insulin dependent diabetes mellitus QTL 205.10.000008blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)14131893212Rat
2302045Pia39Pristane induced arthritis QTL 394.90.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G2a level (CMO:0002116)14862139853621398Rat

Markers in Region
BF399376  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21412,727,809 - 12,727,975 (+)MAPPERmRatBN7.2
Rnor_6.01414,372,023 - 14,372,188NCBIRnor6.0
Rnor_5.01414,313,748 - 14,313,913UniSTSRnor5.0
RGSC_v3.41414,243,328 - 14,243,493UniSTSRGSC3.4
Celera1412,785,521 - 12,785,686UniSTS
Cytogenetic Map14p22UniSTS
AA998890  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21412,729,650 - 12,729,855 (+)MAPPERmRatBN7.2
Rnor_6.01414,373,864 - 14,374,068NCBIRnor6.0
Rnor_5.01414,315,589 - 14,315,793UniSTSRnor5.0
RGSC_v3.41414,245,169 - 14,245,373UniSTSRGSC3.4
Celera1412,787,362 - 12,787,566UniSTS
RH 3.4 Map14157.27UniSTS
Cytogenetic Map14p22UniSTS
RH129015  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21412,728,887 - 12,729,090 (+)MAPPERmRatBN7.2
Rnor_6.01414,373,101 - 14,373,303NCBIRnor6.0
Rnor_5.01414,314,826 - 14,315,028UniSTSRnor5.0
RGSC_v3.41414,244,406 - 14,244,608UniSTSRGSC3.4
Celera1412,786,599 - 12,786,801UniSTS
RH 3.4 Map14156.57UniSTS
Cytogenetic Map14p22UniSTS
RH94682  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21412,729,659 - 12,729,855 (+)MAPPERmRatBN7.2
Rnor_6.01414,373,873 - 14,374,068NCBIRnor6.0
Rnor_5.01414,315,598 - 14,315,793UniSTSRnor5.0
RGSC_v3.41414,245,178 - 14,245,373UniSTSRGSC3.4
Celera1412,787,371 - 12,787,566UniSTS
RH 3.4 Map14155.77UniSTS
Cytogenetic Map14p22UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 163 91 90 59 84 59 6 348 184 11 142 81 92 31 15 15

Sequence


Ensembl Acc Id: ENSRNOT00000046639   ⟹   ENSRNOP00000044431
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1413,023,762 - 13,050,453 (-)Ensembl
mRatBN7.2 Ensembl1412,719,795 - 12,746,486 (-)Ensembl
Rnor_6.0 Ensembl1414,364,008 - 14,390,699 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000068134   ⟹   ENSRNOP00000063496
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1413,031,675 - 13,085,597 (-)Ensembl
mRatBN7.2 Ensembl1412,728,850 - 12,781,617 (-)Ensembl
Rnor_6.0 Ensembl1414,371,928 - 14,426,437 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000096016   ⟹   ENSRNOP00000087567
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1413,031,675 - 13,085,597 (-)Ensembl
mRatBN7.2 Ensembl1412,728,850 - 12,781,609 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000119515   ⟹   ENSRNOP00000092897
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1413,031,675 - 13,085,597 (-)Ensembl
mRatBN7.2 Ensembl1412,729,566 - 12,778,174 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000125453   ⟹   ENSRNOP00000100614
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1413,031,675 - 13,069,331 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000156582   ⟹   ENSRNOP00000101011
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1413,031,675 - 13,085,849 (-)Ensembl
RefSeq Acc Id: NM_012823   ⟹   NP_036955
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81413,031,675 - 13,085,597 (-)NCBI
mRatBN7.21412,727,708 - 12,781,634 (-)NCBI
Rnor_6.01414,371,921 - 14,426,437 (-)NCBI
Rnor_5.01414,313,646 - 14,368,216 (-)NCBI
RGSC_v3.41414,245,112 - 14,297,100 (-)RGD
Celera1412,785,419 - 12,839,165 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006250696   ⟹   XP_006250758
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81413,033,534 - 13,085,678 (-)NCBI
mRatBN7.21412,728,851 - 12,781,701 (-)NCBI
Rnor_6.01414,373,064 - 14,426,503 (-)NCBI
Rnor_5.01414,313,646 - 14,368,216 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039091632   ⟹   XP_038947560
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81413,033,534 - 13,085,675 (-)NCBI
mRatBN7.21412,728,851 - 12,781,701 (-)NCBI
RefSeq Acc Id: XM_063272868   ⟹   XP_063128938
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81413,033,534 - 13,083,038 (-)NCBI
RefSeq Acc Id: NP_036955   ⟸   NM_012823
- UniProtKB: Q642C2 (UniProtKB/Swiss-Prot),   P14669 (UniProtKB/Swiss-Prot),   A6K668 (UniProtKB/TrEMBL),   A0A8I6A4M3 (UniProtKB/TrEMBL),   A6K669 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006250758   ⟸   XM_006250696
- Peptide Label: isoform X1
- UniProtKB: Q642C2 (UniProtKB/Swiss-Prot),   P14669 (UniProtKB/Swiss-Prot),   A6K668 (UniProtKB/TrEMBL),   A0A8I6A4M3 (UniProtKB/TrEMBL),   A6K669 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000063496   ⟸   ENSRNOT00000068134
Ensembl Acc Id: ENSRNOP00000044431   ⟸   ENSRNOT00000046639
RefSeq Acc Id: XP_038947560   ⟸   XM_039091632
- Peptide Label: isoform X1
- UniProtKB: P14669 (UniProtKB/Swiss-Prot),   Q642C2 (UniProtKB/Swiss-Prot),   A6K668 (UniProtKB/TrEMBL),   A0A8I6A4M3 (UniProtKB/TrEMBL),   A6K669 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000092897   ⟸   ENSRNOT00000119515
Ensembl Acc Id: ENSRNOP00000087567   ⟸   ENSRNOT00000096016
RefSeq Acc Id: XP_063128938   ⟸   XM_063272868
- Peptide Label: isoform X1
- UniProtKB: Q642C2 (UniProtKB/Swiss-Prot),   P14669 (UniProtKB/Swiss-Prot),   A6K668 (UniProtKB/TrEMBL),   A0A8I6A4M3 (UniProtKB/TrEMBL),   A6K669 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000101011   ⟸   ENSRNOT00000156582
Ensembl Acc Id: ENSRNOP00000100614   ⟸   ENSRNOT00000125453

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P14669-F1-model_v2 AlphaFold P14669 1-324 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13699202
Promoter ID:EPDNEW_R9727
Type:initiation region
Name:Anxa3_1
Description:annexin A3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01414,426,407 - 14,426,467EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2119 AgrOrtholog
BioCyc Gene G2FUF-16327 BioCyc
Ensembl Genes ENSRNOG00000002045 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000068134 ENTREZGENE
  ENSRNOT00000068134.4 UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.220.10 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7191216 IMAGE-MGC_LOAD
InterPro Annexin UniProtKB/Swiss-Prot
  Annexin_repeat UniProtKB/Swiss-Prot
  Annexin_repeat_CS UniProtKB/Swiss-Prot
  Annexin_sf UniProtKB/Swiss-Prot
  ANX3 UniProtKB/Swiss-Prot
KEGG Report rno:25291 UniProtKB/Swiss-Prot
MGC_CLONE MGC:93656 IMAGE-MGC_LOAD
NCBI Gene 25291 ENTREZGENE
PANTHER ANNEXIN UniProtKB/Swiss-Prot
  PTHR10502:SF25 UniProtKB/Swiss-Prot
Pfam Annexin UniProtKB/Swiss-Prot
PhenoGen Anxa3 PhenoGen
PRINTS ANNEXIN UniProtKB/Swiss-Prot
  ANNEXINIII UniProtKB/Swiss-Prot
PROSITE ANNEXIN UniProtKB/Swiss-Prot
  ANNEXIN_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000002045 RatGTEx
SMART ANX UniProtKB/Swiss-Prot
Superfamily-SCOP SSF47874 UniProtKB/Swiss-Prot
TIGR TC205212
UniProt A0A8I6A4M3 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AIF7_RAT UniProtKB/TrEMBL
  A0ABK0LCT9_RAT UniProtKB/TrEMBL
  A0ABK0LHN1_RAT UniProtKB/TrEMBL
  A6K667_RAT UniProtKB/TrEMBL
  A6K668 ENTREZGENE, UniProtKB/TrEMBL
  A6K669 ENTREZGENE, UniProtKB/TrEMBL
  ANXA3_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q642C2 ENTREZGENE
  Q6TXF2_RAT UniProtKB/TrEMBL
UniProt Secondary Q642C2 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-09-10 Anxa3  annexin A3  Anx3  Annexin III (Lipocortin III)  Symbol and Name updated 1299863 APPROVED
2002-06-10 Anx3  Annexin III (Lipocortin III)      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_process inhibits phospholipase A2 activity 634646
gene_protein 35 kDa membrane binding protein that is calcium and phospholipid dependent 634646