Amh (anti-Mullerian hormone) - Rat Genome Database

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Gene: Amh (anti-Mullerian hormone) Rattus norvegicus
Analyze
Symbol: Amh
Name: anti-Mullerian hormone
RGD ID: 2108
Description: Enables transforming growth factor beta receptor binding activity. Involved in negative regulation of ovarian follicle development; preantral ovarian follicle growth; and response to xenobiotic stimulus. Acts upstream of or within urogenital system development. Located in extracellular space. Human ortholog(s) of this gene implicated in disorder of sexual development; ovarian carcinoma; and persistent Mullerian duct syndrome. Orthologous to human AMH (anti-Mullerian hormone); PARTICIPATES IN cytokine mediated signaling pathway; transforming growth factor-beta superfamily mediated signaling pathway; INTERACTS WITH 1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane; 17alpha-ethynylestradiol; 17beta-estradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: anti - Mullerian hormone; Anti - Mullerian hormone (Mulerian inhibiting substance); anti-Muellerian hormone; MIS; muellerian-inhibiting factor; muellerian-inhibiting substance
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr879,557,451 - 9,559,867 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl79,557,451 - 9,559,867 (-)EnsemblGRCr8
mRatBN7.278,906,776 - 8,909,192 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl78,906,836 - 8,909,282 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx711,785,516 - 11,787,864 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0713,661,021 - 13,663,369 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0711,527,544 - 11,529,892 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0711,775,155 - 11,777,503 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl711,775,155 - 11,777,503 (-)Ensemblrn6Rnor6.0
Rnor_5.0711,942,870 - 11,945,218 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4710,417,325 - 10,419,673 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera77,089,574 - 7,091,922 (-)NCBICelera
RGSC_v3.1710,417,324 - 10,419,673 (-)NCBI
Cytogenetic Map7q11NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane  (EXP)
1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-17-methylestra-4,9,11-trien-3-one  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (EXP)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP)
2,4,4'-trichlorobiphenyl  (ISO)
2-methylcholine  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,3',5-triiodo-L-thyronine  (EXP)
4-nonylphenol  (ISO)
4-vinylcyclohexene dioxide  (EXP)
5-aza-2'-deoxycytidine  (ISO)
5-hydroxymethylfurfural  (EXP)
6-propyl-2-thiouracil  (EXP,ISO)
all-trans-retinoic acid  (ISO)
allethrin  (EXP)
amitrole  (EXP)
ammonium chloride  (EXP)
amoxicillin  (ISO)
aristolochic acid A  (ISO)
benzo[a]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (EXP)
Bisphenol B  (EXP)
butanal  (ISO)
Butylbenzyl phthalate  (EXP)
Butylparaben  (EXP)
cadmium atom  (EXP)
cadmium dichloride  (EXP,ISO)
captan  (ISO)
carbamazepine  (ISO)
carmustine  (ISO)
chlordecone  (ISO)
chlorpyrifos  (ISO)
cilostazol  (EXP)
cisplatin  (EXP,ISO)
cocaine  (EXP)
Cuprizon  (EXP)
cyclophosphamide  (EXP,ISO)
cyhalothrin  (EXP)
cypermethrin  (EXP,ISO)
dexamethasone  (EXP)
dibutyl phthalate  (EXP,ISO)
diclofenac  (ISO)
diethylstilbestrol  (EXP)
dimethomorph  (EXP)
donepezil hydrochloride  (ISO)
Ethylenethiourea  (ISO)
fenvalerate  (EXP)
genistein  (EXP)
gentamycin  (EXP)
ibuprofen  (ISO)
iron dichloride  (ISO)
ketoconazole  (ISO)
lamotrigine  (ISO)
melatonin  (EXP)
methimazole  (EXP)
methoxychlor  (EXP)
methylparaben  (EXP)
mono(2-ethylhexyl) phthalate  (EXP,ISO)
mono(5-carboxy-2-ethylpentyl) phthalate  (ISO)
monoethyl phthalate  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
paclitaxel  (EXP)
paracetamol  (EXP,ISO)
paraquat  (EXP)
parthenolide  (EXP)
PCB138  (ISO)
perfluorononanoic acid  (EXP)
potassium chromate  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
procymidone  (EXP)
propylparaben  (EXP)
prothioconazole  (ISO)
pyrethrins  (EXP)
pyrimidifen  (ISO)
resmethrin  (ISO)
resveratrol  (EXP)
rotenone  (ISO)
sodium arsenite  (ISO)
sulforaphane  (ISO)
testosterone  (ISO)
Theaflavin 3,3'-digallate  (ISO)
thiram  (ISO)
thyroxine  (EXP)
titanium dioxide  (ISO)
triphenylstannane  (EXP)
Triptolide  (ISO)
triptonide  (ISO)
trovafloxacin  (ISO)
Ulipristal  (EXP)
valproic acid  (ISO)
vinclozolin  (EXP)
vincristine  (ISO)
ziram  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (ISO)
extracellular region  (IEA)
extracellular space  (IBA,IDA,IEA,ISO)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Parabens inhibit the early phase of folliculogenesis and steroidogenesis in the ovaries of neonatal rats. Ahn HJ, etal., Mol Reprod Dev. 2012 Sep;79(9):626-36. doi: 10.1002/mrd.22070. Epub 2012 Jul 26.
2. Acute effects of metformin therapy include improvement of insulin resistance and ovarian morphology. Bayrak A, etal., Fertil Steril. 2007 Jan 12;.
3. Regulation of gonadotropin gene expression by Mullerian inhibiting substance. Bedecarrats GY, etal., Proc Natl Acad Sci U S A 2003 Aug 5;100(16):9348-53. Epub 2003 Jul 23.
4. Anti-Mullerian hormone inhibits initiation of growth of human primordial ovarian follicles in vitro. Carlsson IB, etal., Hum Reprod. 2006 Sep;21(9):2223-7. Epub 2006 May 23.
5. Variants of the anti-Mullerian hormone gene in a compound heterozygote with the persistent Mullerian duct syndrome and his family. Carre-Eusebe D, etal., Hum Genet. 1992 Dec;90(4):389-94.
6. Serum Mullerian Inhibiting Substance/anti-Mullerian hormone levels in patients with adult granulosa cell tumors directly correlate with aggregate tumor mass as determined by pathology or radiology. Chang HL, etal., Gynecol Oncol. 2009 Jul;114(1):57-60. Epub 2009 Apr 8.
7. Prospective case-control study of serum mullerian inhibiting substance and breast cancer risk. Dorgan JF, etal., J Natl Cancer Inst. 2009 Nov 4;101(21):1501-9. Epub 2009 Oct 9.
8. Association of anti-mullerian hormone levels with obesity in late reproductive-age women. Freeman EW, etal., Fertil Steril. 2007 Jan;87(1):101-6. Epub 2006 Nov 15.
9. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
10. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
11. Isolation of the rat gene for Mullerian inhibiting substance. Haqq C, etal., Genomics 1992 Apr;12(4):665-9.
12. Increased expression of Mullerian-inhibiting substance correlates with inhibition of follicular growth in the developing ovary of rats treated with E2 benzoate. Ikeda Y, etal., Endocrinology 2002 Jan;143(1):304-12.
13. Parabens Accelerate Ovarian Dysfunction in a 4-Vinylcyclohexene Diepoxide-Induced Ovarian Failure Model. Lee JH, etal., Int J Environ Res Public Health. 2017 Feb 8;14(2). pii: ijerph14020161. doi: 10.3390/ijerph14020161.
14. Mullerian inhibitory substance induces growth of rat preantral ovarian follicles. McGee EA, etal., Biol Reprod. 2001 Jan;64(1):293-8.
15. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
16. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
17. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
18. Recombinant human Mullerian inhibiting substance inhibits long-term growth of MIS type II receptor-directed transgenic mouse ovarian cancers in vivo. Pieretti-Vanmarcke R, etal., Clin Cancer Res. 2006 Mar 1;12(5):1593-8.
19. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
20. GOA pipeline RGD automated data pipeline
21. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
22. Mullerian inhibiting substance regulates NFkappaB signaling and growth of mammary epithelial cells in vivo. Segev DL, etal., J Biol Chem 2001 Jul 20;276(29):26799-806.
23. The expression of Mullerian inhibiting substance/anti-Mullerian hormone type II receptor protein and mRNA in benign, borderline and malignant ovarian neoplasia. Song JY, etal., Int J Oncol. 2009 Jun;34(6):1583-91.
24. Extracellular domain of YWK-II, a human sperm transmembrane protein, interacts with rat Mullerian-inhibiting substance. Tian XY, etal., Reproduction. 2001 Jun;121(6):873-80.
25. Early postnatal methoxychlor exposure inhibits folliculogenesis and stimulates anti-Mullerian hormone production in the rat ovary. Uzumcu M, etal., J Endocrinol. 2006 Dec;191(3):549-58.
26. The serine/threonine transmembrane receptor ALK2 mediates Mullerian inhibiting substance signaling. Visser JA, etal., Mol Endocrinol. 2001 Jun;15(6):936-45.
27. Mullerian inhibiting substance as a novel biomarker of cisplatin-induced ovarian damage. Yeh J, etal., Biochem Biophys Res Commun. 2006 Sep 22;348(2):337-44. Epub 2006 Jul 13.
28. Serum and ovarian Mullerian inhibiting substance, and their decline in reproductive aging. Yeh J, etal., Fertil Steril. 2007 May;87(5):1227-30. Epub 2007 Jan 12.
Additional References at PubMed
PMID:14585814   PMID:14695376   PMID:14750901   PMID:15789443   PMID:16207837   PMID:20816688   PMID:21637711   PMID:25667201   PMID:26753790   PMID:27030385   PMID:31724927   PMID:32387527  
PMID:33709094   PMID:37633225  


Genomics

Comparative Map Data
Amh
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr879,557,451 - 9,559,867 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl79,557,451 - 9,559,867 (-)EnsemblGRCr8
mRatBN7.278,906,776 - 8,909,192 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl78,906,836 - 8,909,282 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx711,785,516 - 11,787,864 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0713,661,021 - 13,663,369 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0711,527,544 - 11,529,892 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0711,775,155 - 11,777,503 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl711,775,155 - 11,777,503 (-)Ensemblrn6Rnor6.0
Rnor_5.0711,942,870 - 11,945,218 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4710,417,325 - 10,419,673 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera77,089,574 - 7,091,922 (-)NCBICelera
RGSC_v3.1710,417,324 - 10,419,673 (-)NCBI
Cytogenetic Map7q11NCBI
AMH
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38192,249,323 - 2,252,073 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl192,249,309 - 2,252,073 (+)Ensemblhg38GRCh38
GRCh37192,249,322 - 2,252,072 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36192,200,113 - 2,203,072 (+)NCBIBuild 36Build 36hg18NCBI36
Build 34192,200,121 - 2,203,071NCBI
Celera192,183,289 - 2,186,248 (+)NCBICelera
Cytogenetic Map19p13.3NCBI
HuRef192,020,229 - 2,023,188 (+)NCBIHuRef
CHM1_1192,248,616 - 2,251,575 (+)NCBICHM1_1
T2T-CHM13v2.0192,222,966 - 2,225,716 (+)NCBIT2T-CHM13v2.0
Amh
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391080,641,074 - 80,643,513 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1080,641,077 - 80,643,482 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381080,805,240 - 80,807,679 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1080,805,243 - 80,807,648 (+)Ensemblmm10GRCm38
MGSCv371080,267,993 - 80,270,393 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361080,208,377 - 80,210,777 (+)NCBIMGSCv36mm8
Celera1081,823,618 - 81,826,018 (+)NCBICelera
Cytogenetic Map10C1NCBI
cM Map1039.72NCBI
Amh
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554955,893,446 - 5,895,912 (-)Ensembl
ChiLan1.0NW_0049554955,893,375 - 5,896,152 (-)NCBIChiLan1.0ChiLan1.0
AMH
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2206,633,643 - 6,636,931 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1195,862,984 - 5,866,275 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0191,260,219 - 1,263,395 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1192,231,984 - 2,236,130 (+)NCBIPanPan1.1PanPan1.1panPan2
AMH
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12056,785,960 - 56,788,815 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2056,581,099 - 56,583,889 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02057,518,896 - 57,521,686 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2057,518,814 - 57,521,686 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12056,570,917 - 56,573,707 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02057,056,052 - 57,058,835 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02057,256,543 - 57,259,332 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Amh
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118216,489,037 - 216,492,075 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365881,343,085 - 1,345,654 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365881,342,791 - 1,345,746 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
AMH
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl276,414,427 - 76,418,312 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1276,415,564 - 76,418,315 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2276,982,764 - 76,983,243 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap2q14-q21NCBI
AMH
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.162,047,756 - 2,051,073 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl62,048,319 - 2,050,958 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_0236660816,669,905 - 6,672,763 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Amh
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248286,631,420 - 6,637,732 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248286,635,192 - 6,638,104 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Amh
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11154,077,820 - 154,080,225 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Amh
5 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:42
Count of miRNA genes:40
Interacting mature miRNAs:42
Transcripts:ENSRNOT00000026220
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61410Bw19Body weight QTL 196.20.001body mass (VT:0001259)body weight (CMO:0000012)7166965846669658Rat
1300176Hrtrt10Heart rate QTL 103.19heart pumping trait (VT:2000009)heart rate (CMO:0000002)7123748937Rat
9590102Sffal5Serum free fatty acids level QTL 58.620.001blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)7721609752216097Rat
2290372Gluco33Glucose level QTL 332.71blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)7131777942Rat
1300149Cm6Cardiac mass QTL 64.09heart mass (VT:0007028)heart left ventricle weight to body weight ratio (CMO:0000530)71104117804Rat
631503Bp102Blood pressure QTL 1021.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)7170952746709527Rat
634336Anxrr17Anxiety related response QTL 173.66locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)71509236116977875Rat
9590142Scort5Serum corticosterone level QTL 524.40.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)7132612984Rat
1582260Bw72Body weight QTL 723.20.0043body mass (VT:0001259)body weight (CMO:0000012)7139960528Rat
1582261Bw69Body weight QTL 693.20.0048body mass (VT:0001259)body weight (CMO:0000012)7139960528Rat
1582262Bw75Body weight QTL 7530.0038body mass (VT:0001259)body weight (CMO:0000012)7139960528Rat
10059592Kidm45Kidney mass QTL 453.950.025kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)7946087754460877Rat
2298550Neuinf6Neuroinflammation QTL 63.3nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)7129716167Rat
724560Plsm3Polydactyly-luxate syndrome (PLS) morphotypes QTL 30.0003tibia length (VT:0004357)tibia length (CMO:0000450)7134650782Rat
7411566Bw136Body weight QTL 13610.40.001body mass (VT:0001259)body weight gain (CMO:0000420)7132612984Rat

Markers in Region
PMC203309P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.278,907,628 - 8,907,816 (+)MAPPERmRatBN7.2
Rnor_6.0711,775,948 - 11,776,135NCBIRnor6.0
Rnor_5.0711,943,663 - 11,943,850UniSTSRnor5.0
RGSC_v3.4710,418,118 - 10,418,305UniSTSRGSC3.4
Celera77,090,367 - 7,090,554UniSTS
Cytogenetic Map7q11UniSTS
UniSTS:547550  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.278,908,033 - 8,908,431 (+)MAPPERmRatBN7.2
Rnor_6.0711,776,353 - 11,776,750NCBIRnor6.0
Rnor_5.0711,944,068 - 11,944,465UniSTSRnor5.0
Celera77,090,772 - 7,091,169UniSTS
Cytogenetic Map7q11UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
14 11 63 154 80 77 48 81 48 6 308 172 6 133 66 91 29 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000026220   ⟹   ENSRNOP00000026220
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl79,557,451 - 9,559,867 (-)Ensembl
mRatBN7.2 Ensembl78,906,836 - 8,909,282 (-)Ensembl
Rnor_6.0 Ensembl711,775,155 - 11,777,503 (-)Ensembl
RefSeq Acc Id: NM_012902   ⟹   NP_037034
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr879,557,451 - 9,559,867 (-)NCBI
mRatBN7.278,906,776 - 8,909,192 (-)NCBI
Rnor_6.0711,775,155 - 11,777,503 (-)NCBI
Rnor_5.0711,942,870 - 11,945,218 (-)NCBI
RGSC_v3.4710,417,325 - 10,419,673 (-)RGD
Celera77,089,574 - 7,091,922 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_037034 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAB22104 (Get FASTA)   NCBI Sequence Viewer  
  EDL89230 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000026220
  ENSRNOP00000026220.1
GenBank Protein P49000 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_037034   ⟸   NM_012902
- Peptide Label: precursor
- UniProtKB: P49000 (UniProtKB/Swiss-Prot),   A6K8G0 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000026220   ⟸   ENSRNOT00000026220
Protein Domains
TGF-beta family profile

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P49000-F1-model_v2 AlphaFold P49000 1-553 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13695003
Promoter ID:EPDNEW_R5528
Type:single initiation site
Name:Amh_1
Description:anti-Mullerian hormone
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0711,777,488 - 11,777,548EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2108 AgrOrtholog
BioCyc Gene G2FUF-34968 BioCyc
Ensembl Genes ENSRNOG00000019377 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000026220 ENTREZGENE
  ENSRNOT00000026220.3 UniProtKB/Swiss-Prot
Gene3D-CATH 2.10.90.10 UniProtKB/Swiss-Prot
InterPro AMH_N UniProtKB/Swiss-Prot
  Cystine-knot_cytokine UniProtKB/Swiss-Prot
  Muellerian-inhibiting_factor UniProtKB/Swiss-Prot
  TGF-b_C UniProtKB/Swiss-Prot
  TGFb_CS UniProtKB/Swiss-Prot
KEGG Report rno:25378 UniProtKB/Swiss-Prot
NCBI Gene 25378 ENTREZGENE
PANTHER MUELLERIAN-INHIBITING FACTOR UniProtKB/Swiss-Prot
  PTHR15009 UniProtKB/Swiss-Prot
Pfam AMH_N UniProtKB/Swiss-Prot
  TGF_beta UniProtKB/Swiss-Prot
PhenoGen Amh PhenoGen
PIRSF Muellerian-inhibiting_factor UniProtKB/Swiss-Prot
PROSITE TGF_BETA_1 UniProtKB/Swiss-Prot
  TGF_BETA_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000019377 RatGTEx
SMART TGFB UniProtKB/Swiss-Prot
Superfamily-SCOP SSF57501 UniProtKB/Swiss-Prot
UniProt A6K8G0 ENTREZGENE, UniProtKB/TrEMBL
  MIS_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-02-26 Amh  anti-Mullerian hormone    anti-mullerian hormone  Symbol and Name status set to approved 625702 APPROVED
2002-06-10 Amh  anti-mullerian hormone      Name updated 70585 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_disease inhibits human breast cancer cell growth in vitro through interference with cell cycle progression and induction of apoptosis 70295
gene_disease inhibits human breast cancer cell growth in vitro through interference with cell cycle progression and induction of apoptosis 70576
gene_expression produced by Sertoli cells of the testis (males); in females, synthesized by granulosa cells of the ovary and persists until menopause 70295
gene_expression produced by Sertoli cells of the testis (males); in females, synthesized by granulosa cells of the ovary and persists until menopause 70576
gene_expression expressed in the granulosa small growing follicles in the ovary 70295
gene_expression expressed in the granulosa small growing follicles in the ovary 70576
gene_expression expression is high in the 1-day-postnatal testis and decreases to a low level in the adult testis 1298546
gene_function testicular glycoprotein ligand for MIS receptor II that causes regression of Mullerian duct, the fallopian tubes and part of the vagina 1298546
gene_process responsible for the regression of Mullerian duct in male embryos 70295
gene_process responsible for the regression of Mullerian duct in male embryos 70576
gene_process plays a key role in male sexual development and differentiation 1298546
gene_process regulates such hypothalamic/pituitary/gonadal axis processes as steroidogenesis, breast and prostate growth, and ovarian follicle recruitment 1298576
gene_process enhances the effect of gonadotropin-releasing hormone (GnRH) agonist on the FSHbeta gene promoter and synergizes with the GnRH agonist to stimulate LHbeta gene promoter activity 1298576
gene_process regulates follicular growth 70576
gene_process contributes to ovarian development 70576
gene_process impedes cell cycle progression and apoptosis induction and thus breast cancer cell growth 70295
gene_process induces NFkappaB to bind to its cognate DNA sequence 70295
gene_process enhances IEX-1S mRNA expression in breast tissue 70295
gene_process increases apoptosis in the mouse mammary ductal epithelium 70295
gene_process potential endogenous hormonal regulator of NFkappaB signaling and growth in breast tissue 70295
gene_product member of the transforming growth factor b family  
gene_regulation mRNA and protein expression in ovary increased by E2 benzoate; reduction is correlated with the inhibotory effect of EB on the follicular stratification 70295
gene_regulation mRNA and protein expression in ovary increased by E2 benzoate; reduction is correlated with the inhibotory effect of EB on the follicular stratification 70576
gene_regulation transcription is estrogen responsive 70576
gene_regulation activated by steroidogenic factor 1 70576