Acp2 (acid phosphatase 2, lysosomal) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Behavioral & Substance Use Disorder Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Acp2 (acid phosphatase 2, lysosomal) Rattus norvegicus
Analyze
Symbol: Acp2
Name: acid phosphatase 2, lysosomal
RGD ID: 2021
Description: Enables acid phosphatase activity; phosphoprotein phosphatase activity; and phosphotyrosine residue binding activity. Involved in autophagic cell death and response to cGMP. Predicted to be located in lysosomal lumen; lysosomal membrane; and synapse. Predicted to be active in lysosome. Orthologous to human ACP2 (acid phosphatase 2, lysosomal); PARTICIPATES IN autophagy pathway; riboflavin metabolic pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,6-dinitrotoluene; 3,3',4,4',5-pentachlorobiphenyl.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: acid phosphatase 2; Acid phosphatase 2 lysozymal; Acid phosphatase 2, lysozymal; LAP; LMW-PTP-II low molecular weight phosphotyrosine protein phosphatase isozyme 2; LMW-PTP-II, low molecular weight phosphotyrosine protein phosphatase isozyme 2; lysosomal acid phosphatase
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8397,630,654 - 97,642,601 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl397,631,326 - 97,642,565 (+)EnsemblGRCr8
mRatBN7.2377,175,022 - 77,185,180 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl377,175,895 - 77,185,680 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx380,654,465 - 80,663,379 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0389,253,472 - 89,262,386 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0387,104,531 - 87,113,457 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0380,020,346 - 80,030,365 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl380,021,440 - 80,030,363 (+)Ensemblrn6Rnor6.0
Rnor_5.0386,729,100 - 86,739,118 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4375,559,522 - 75,568,415 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera376,384,458 - 76,393,383 (+)NCBICelera
RGSC_v3.1375,455,893 - 75,464,787 (+)NCBI
Cytogenetic Map3q24NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (ISO)
14-Deoxy-11,12-didehydroandrographolide  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3-dimethoxynaphthalene-1,4-dione  (ISO)
2,6-dinitrotoluene  (EXP)
2-bromohexadecanoic acid  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,4-methylenedioxymethamphetamine  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
6-propyl-2-thiouracil  (EXP)
acrylamide  (EXP)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
amitrole  (EXP)
ammonium chloride  (EXP)
anthracene  (ISO)
antimony(0)  (ISO)
antirheumatic drug  (ISO)
Aroclor 1254  (EXP)
benzo[a]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
Bisphenol B  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
chlorpyrifos  (ISO)
chromium atom  (ISO)
clotrimazole  (EXP)
cobalt dichloride  (EXP)
cyclosporin A  (ISO)
cyproconazole  (ISO)
dibenzofurans  (ISO)
Dibutyl phosphate  (ISO)
dipotassium bis[mu-tartrato(4-)]diantimonate(2-) trihydrate  (ISO)
doxorubicin  (ISO)
epoxiconazole  (ISO)
ethanol  (ISO)
fipronil  (EXP)
flutamide  (EXP)
folic acid  (ISO)
gentamycin  (EXP)
GSK-J4  (ISO)
inulin  (ISO)
iron dichloride  (ISO)
ivermectin  (ISO)
leflunomide  (EXP)
mercury atom  (ISO)
mercury(0)  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-nitrosodimethylamine  (ISO)
naphthalene  (ISO)
nefazodone  (EXP)
p-toluidine  (EXP)
paracetamol  (EXP,ISO)
pentachlorophenol  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenanthrene  (ISO)
phenobarbital  (ISO)
pirinixic acid  (ISO)
potassium dichromate  (ISO)
propiconazole  (ISO)
pyrene  (ISO)
rotenone  (ISO)
SB 431542  (ISO)
Soman  (EXP)
sulfadimethoxine  (EXP)
sulindac  (ISO)
temozolomide  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
triphenyl phosphate  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Kinetic studies on rat liver low M(r) phosphotyrosine protein phosphatases. The activation mechanism of the isoenzyme AcP2 by cGMP. Cirri P, etal., Biochim Biophys Acta 1995 Jan 18;1243(1):129-35.
2. Combined apoptosis and autophagy, the process that eliminates the oocytes of atretic follicles in immature rats. Escobar ML, etal., Apoptosis. 2008 Oct;13(10):1253-66.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. Isolation and sequencing of a cDNA clone encoding acid phosphatase in rat liver lysosomes. Himeno M, etal., Biochem Biophys Res Commun 1989 Aug 15;162(3):1044-53.
6. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
7. Changes in the activity of lysosomal enzymes in rat kidneys in the course of acute pancreatitis. Lakowska H, etal., Med Sci Monit. 2001 Nov-Dec;7(6):1193-7.
8. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
9. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
10. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
11. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
12. GOA pipeline RGD automated data pipeline
13. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
14. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
15. Mice deficient in lysosomal acid phosphatase develop lysosomal storage in the kidney and central nervous system. Saftig P, etal., J Biol Chem 1997 Jul 25;272(30):18628-35.
16. Dephosphorylation of tyrosine phosphorylated synthetic peptides by rat liver phosphotyrosine protein phosphatase isoenzymes. Stefani M, etal., FEBS Lett. 1993 Jul 12;326(1-3):131-4.
17. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
18. Abundance of low molecular weight phosphotyrosine protein phosphatase in the nerve-ending fraction in the brain. Tanino H, etal., Biol Pharm Bull 1999 Aug;22(8):794-8.
19. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
Additional References at PubMed
PMID:1914521   PMID:3160696   PMID:11168643   PMID:11731469   PMID:15503243   PMID:15604265   PMID:19946888   PMID:23376485   PMID:23533145   PMID:25013167  


Genomics

Comparative Map Data
Acp2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8397,630,654 - 97,642,601 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl397,631,326 - 97,642,565 (+)EnsemblGRCr8
mRatBN7.2377,175,022 - 77,185,180 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl377,175,895 - 77,185,680 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx380,654,465 - 80,663,379 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0389,253,472 - 89,262,386 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0387,104,531 - 87,113,457 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0380,020,346 - 80,030,365 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl380,021,440 - 80,030,363 (+)Ensemblrn6Rnor6.0
Rnor_5.0386,729,100 - 86,739,118 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4375,559,522 - 75,568,415 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera376,384,458 - 76,393,383 (+)NCBICelera
RGSC_v3.1375,455,893 - 75,464,787 (+)NCBI
Cytogenetic Map3q24NCBI
ACP2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381147,239,302 - 47,248,814 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1147,238,400 - 47,249,288 (-)Ensemblhg38GRCh38
GRCh371147,260,853 - 47,270,365 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361147,217,429 - 47,226,939 (-)NCBIBuild 36Build 36hg18NCBI36
Build 341147,217,428 - 47,226,939NCBI
Celera1147,400,080 - 47,409,684 (-)NCBICelera
Cytogenetic Map11p11.2NCBI
HuRef1146,959,833 - 46,969,437 (-)NCBIHuRef
CHM1_11147,259,545 - 47,269,147 (-)NCBICHM1_1
T2T-CHM13v2.01147,396,045 - 47,405,572 (-)NCBIT2T-CHM13v2.0
Acp2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39291,033,157 - 91,044,443 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl291,033,230 - 91,044,443 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38291,202,812 - 91,214,098 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl291,202,885 - 91,214,098 (+)Ensemblmm10GRCm38
MGSCv37291,043,069 - 91,054,255 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36291,003,769 - 91,012,982 (+)NCBIMGSCv36mm8
Celera292,588,418 - 92,599,572 (+)NCBICelera
Cytogenetic Map2E1NCBI
cM Map250.54NCBI
Acp2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955422954,089 - 961,522 (+)Ensembl
ChiLan1.0NW_004955422954,108 - 961,522 (+)NCBIChiLan1.0ChiLan1.0
ACP2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2949,440,359 - 49,449,883 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11149,460,156 - 49,469,677 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01147,185,611 - 47,195,174 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11147,738,845 - 47,748,450 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1147,738,845 - 47,748,450 (-)EnsemblpanPan2panpan1.1
ACP2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11842,346,207 - 42,356,447 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1842,345,608 - 42,354,352 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1841,074,892 - 41,082,823 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01843,000,686 - 43,008,615 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1843,000,671 - 43,010,921 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11842,486,567 - 42,494,663 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01842,042,164 - 42,050,092 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01842,771,565 - 42,779,495 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Acp2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494719,840,945 - 19,848,685 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365621,952,536 - 1,960,327 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365621,952,581 - 1,960,327 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ACP2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl215,334,001 - 15,347,770 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1215,334,015 - 15,342,531 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2216,557,583 - 16,566,096 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ACP2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1118,061,094 - 18,070,929 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl118,060,994 - 18,072,208 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_023666038115,364,071 - 115,374,315 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Acp2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247671,473,205 - 1,485,345 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247671,473,186 - 1,481,395 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Acp2
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1565,366,595 - 65,376,348 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Acp2
61 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:380
Count of miRNA genes:217
Interacting mature miRNAs:256
Transcripts:ENSRNOT00000018620
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300178Hrtrt4Heart rate QTL 43.74heart pumping trait (VT:2000009)heart rate (CMO:0000002)351490129111359995Rat
61377Edpm3Estrogen-dependent pituitary mass QTL 37.050.038pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)373592611110333156Rat
1358293Bw38Body weight QTL 3860.0000031body mass (VT:0001259)body weight (CMO:0000012)374364268119364268Rat
2301414Kidm37Kidney mass QTL 370.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)396509147141509147Rat
1582238Bw68Body weight QTL 683.20.0064body mass (VT:0001259)body weight (CMO:0000012)373592512136118980Rat
1582239Epfw1Epididymal fat weight QTL 14.50.0006epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)373592512136118980Rat
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)351581665184004958Rat
1354589Bw31Body weight QTL 313.3body mass (VT:0001259)body weight (CMO:0000012)35365182698651826Rat
2292591Esta4Estrogen-induced thymic atrophy QTL 4thymus mass (VT:0004954)thymus wet weight (CMO:0000855)367641776167835660Rat
1358362Srcrt2Stress Responsive Cort QTL 22.78blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)358601291153936591Rat
737818Hcar12Hepatocarcinoma resistance QTL 122.6liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)349872657138829559Rat
1582218Bw74Body weight QTL 743.90.0021body mass (VT:0001259)body weight (CMO:0000012)373592512136118980Rat
1582221Kidm30Kidney mass QTL 303.50.0008kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)385062224136118980Rat
1582210Bw71Body weight QTL 713.30.0012body mass (VT:0001259)body weight (CMO:0000012)385062224136118980Rat
1300111Rf12Renal function QTL 123.78renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)381425008141509147Rat
724523Tsu1Thymus enlargement suppressive QTL 13.84thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)370845569136091483Rat
1600376Arunc5Aerobic running capacity QTL 50.21exercise endurance trait (VT:0002332)longest distance run on treadmill (CMO:0001406)393829559138829559Rat
8662816Vetf4Vascular elastic tissue fragility QTL 44renal artery integrity trait (VT:0010642)number of ruptures of the internal elastic lamina of the renal arteries (CMO:0002563)379649560177741895Rat
2292613Ept16Estrogen-induced pituitary tumorigenesis QTL 168.3pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)367641995130815812Rat
1581503Cm58Cardiac mass QTL 582.70.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)396509147141509147Rat
738019Anxrr10Anxiety related response QTL 103.9exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)358925062103925062Rat
631841Niddm39Non-insulin dependent diabetes mellitus QTL 393.36blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)370311536115311536Rat
631200Cm25Cardiac mass QTL 254.80.0001heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)381541464126563126Rat
12879848Bw181Body weght QTL 1810.015body mass (VT:0001259)body weight (CMO:0000012)390755164141509147Rat
1358905Hrtrt17Heart rate QTL 175.90.000014heart pumping trait (VT:2000009)heart rate (CMO:0000002)336721849110333156Rat
1358885Bp251Blood pressure QTL 2513.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)31141509147Rat
1354597Kidm13Kidney mass QTL 132.9kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)342158111124558371Rat
1354604Bw36Body weight QTL 362.9body mass (VT:0001259)body weight (CMO:0000012)342158111124558371Rat
1358888Bp264Blood pressure QTL 2644.43arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)35675975141509147Rat
1358186Ept2Estrogen-induced pituitary tumorigenesis QTL 28.3pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)367641995130815812Rat

Markers in Region
RH131014  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2377,185,232 - 77,185,417 (+)MAPPERmRatBN7.2
Rnor_6.0380,030,556 - 80,030,740NCBIRnor6.0
Rnor_5.0386,739,309 - 86,739,493UniSTSRnor5.0
RGSC_v3.4375,568,606 - 75,568,790UniSTSRGSC3.4
Celera376,393,574 - 76,393,758UniSTS
Cytogenetic Map3q24UniSTS
RH139052  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2377,175,085 - 77,175,266 (+)MAPPERmRatBN7.2
Rnor_6.0380,020,410 - 80,020,590NCBIRnor6.0
Rnor_5.0386,729,163 - 86,729,343UniSTSRnor5.0
RGSC_v3.4375,558,460 - 75,558,640UniSTSRGSC3.4
Celera376,383,428 - 76,383,608UniSTS
Cytogenetic Map3q24UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 164 91 90 59 92 59 6 356 192 11 143 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000018620   ⟹   ENSRNOP00000018620
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl397,631,326 - 97,642,565 (+)Ensembl
mRatBN7.2 Ensembl377,175,895 - 77,185,680 (+)Ensembl
Rnor_6.0 Ensembl380,021,440 - 80,030,363 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000106898   ⟹   ENSRNOP00000081459
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl397,631,495 - 97,642,565 (+)Ensembl
mRatBN7.2 Ensembl377,175,895 - 77,185,680 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000109523   ⟹   ENSRNOP00000097452
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl397,631,963 - 97,642,565 (+)Ensembl
mRatBN7.2 Ensembl377,176,153 - 77,185,680 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000123449   ⟹   ENSRNOP00000105616
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl397,631,519 - 97,642,565 (+)Ensembl
RefSeq Acc Id: NM_001357071   ⟹   NP_001344000
RefSeq Status: REVIEWED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8397,631,926 - 97,640,851 (+)NCBI
mRatBN7.2377,176,116 - 77,185,042 (+)NCBI
RefSeq Acc Id: NM_016988   ⟹   NP_058684
RefSeq Status: REVIEWED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8397,631,926 - 97,640,851 (+)NCBI
mRatBN7.2377,176,116 - 77,185,042 (+)NCBI
Rnor_6.0380,021,440 - 80,030,365 (+)NCBI
Rnor_5.0386,729,100 - 86,739,118 (+)NCBI
RGSC_v3.4375,559,522 - 75,568,415 (+)RGD
Celera376,384,458 - 76,393,383 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006234500   ⟹   XP_006234562
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8397,630,654 - 97,642,601 (+)NCBI
mRatBN7.2377,175,022 - 77,185,180 (+)NCBI
Rnor_6.0380,020,346 - 80,030,365 (+)NCBI
Rnor_5.0386,729,100 - 86,739,118 (+)NCBI
Sequence:
RefSeq Acc Id: XM_063283072   ⟹   XP_063139142
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8397,630,654 - 97,642,601 (+)NCBI
RefSeq Acc Id: NP_058684   ⟸   NM_016988
- Peptide Label: isoform 1 precursor
- UniProtKB: P20611 (UniProtKB/Swiss-Prot),   Q642D2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006234562   ⟸   XM_006234500
- Peptide Label: isoform X2
- UniProtKB: F7F1A3 (UniProtKB/TrEMBL),   A6HNB5 (UniProtKB/TrEMBL),   A0A8I5ZST8 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000018620   ⟸   ENSRNOT00000018620
RefSeq Acc Id: NP_001344000   ⟸   NM_001357071
- Peptide Label: isoform 1x precursor
- UniProtKB: P20611 (UniProtKB/Swiss-Prot)
Ensembl Acc Id: ENSRNOP00000081459   ⟸   ENSRNOT00000106898
Ensembl Acc Id: ENSRNOP00000097452   ⟸   ENSRNOT00000109523
RefSeq Acc Id: XP_063139142   ⟸   XM_063283072
- Peptide Label: isoform X1
- UniProtKB: A0A8I5ZST8 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000105616   ⟸   ENSRNOT00000123449

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P20611-F1-model_v2 AlphaFold P20611 1-423 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13692211
Promoter ID:EPDNEW_R2734
Type:multiple initiation site
Name:Acp2_1
Description:acid phosphatase 2, lysosomal
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0380,021,461 - 80,021,521EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2021 AgrOrtholog
BioCyc Gene G2FUF-48742 BioCyc
Ensembl Genes ENSRNOG00000013594 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000018620 ENTREZGENE
  ENSRNOT00000123449 ENTREZGENE
Gene3D-CATH 3.40.50.1240 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7107570 IMAGE-MGC_LOAD
InterPro Acid_Pase_AS UniProtKB/Swiss-Prot
  His_Pase_clade-2 UniProtKB/Swiss-Prot
  His_PPase_superfam UniProtKB/Swiss-Prot
  Histidine_acid_phosphatase UniProtKB/Swiss-Prot
MGC_CLONE MGC:93543 IMAGE-MGC_LOAD
NCBI Gene 24162 ENTREZGENE
PANTHER ACID PHOSPHATASE-RELATED UniProtKB/Swiss-Prot
  LYSOSOMAL ACID PHOSPHATASE UniProtKB/Swiss-Prot
Pfam His_Phos_2 UniProtKB/Swiss-Prot
PharmGKB ACP2 RGD
PhenoGen Acp2 PhenoGen
PROSITE HIS_ACID_PHOSPHAT_1 UniProtKB/Swiss-Prot
  HIS_ACID_PHOSPHAT_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000013594 RatGTEx
Superfamily-SCOP SSF53254 UniProtKB/Swiss-Prot
TIGR TC205149
UniProt A0A8I5ZST8 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6ANF7_RAT UniProtKB/TrEMBL
  A0ABK0LVD4_RAT UniProtKB/TrEMBL
  A6HNB5 ENTREZGENE, UniProtKB/TrEMBL
  A6HNB6_RAT UniProtKB/TrEMBL
  F7F1A3 ENTREZGENE, UniProtKB/TrEMBL
  P20611 ENTREZGENE, UniProtKB/Swiss-Prot
  Q642D2 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-09-10 Acp2  acid phosphatase 2, lysosomal    acid phosphatase 2  Name updated 1299863 APPROVED
2002-06-10 Acp2  acid phosphatase 2      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_cellular_localization localized to nerve endings 631746
gene_expression expressed in liver 631727
gene_expression protein detected in brain 631746
gene_function catalyzes the hydrolysis of p-nitrophenyl phosphate 631727
gene_process may play a role in synaptic function 631746
gene_regulation activated strongly by cyclic GMP and guanosine 631727