Aco1 (aconitase 1) - Rat Genome Database

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Gene: Aco1 (aconitase 1) Rattus norvegicus
Analyze
Symbol: Aco1
Name: aconitase 1
RGD ID: 2019
Description: Enables aconitate hydratase activity; iron-sulfur cluster binding activity; and mRNA binding activity. Involved in intracellular iron ion homeostasis and liver development. Located in Golgi apparatus. Used to study duodenal ulcer and metabolic dysfunction-associated steatotic liver disease. Orthologous to human ACO1 (aconitase 1); PARTICIPATES IN doxorubicin response pathway; iron homeostasis pathway; citric acid cycle pathway; INTERACTS WITH (+)-schisandrin B; 17beta-estradiol; 2,4-dinitrotoluene.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Acon1; Aconitase 1 soluble; aconitase 1, soluble; AH; citrate hydro-lyase; cytoplasmic aconitate hydratase; IRE-BP 1; iron regulatory protein 1; iron-responsive element-binding protein; iron-responsive element-binding protein 1; IRP1; Ratireb
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8560,055,895 - 60,111,920 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl560,055,866 - 60,112,600 (+)EnsemblGRCr8
mRatBN7.2555,259,841 - 55,315,872 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl555,259,827 - 55,316,391 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx557,225,306 - 57,281,119 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0559,044,439 - 59,100,254 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0559,015,833 - 59,071,688 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0556,425,076 - 56,481,218 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl556,425,024 - 56,481,218 (+)Ensemblrn6Rnor6.0
Rnor_5.0560,972,013 - 61,027,705 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4557,536,675 - 57,591,765 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera553,878,712 - 53,934,197 (+)NCBICelera
RGSC_v3.1557,536,853 - 57,591,944 (+)NCBI
Cytogenetic Map5q22NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(1->4)-beta-D-glucan  (ISO)
1,1-dichloroethene  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
2-butoxyethanol  (ISO)
2-nitrofluorene  (EXP)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3-chloropropane-1,2-diol  (EXP)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (EXP)
4-hydroxyphenyl retinamide  (ISO)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (EXP)
6-propyl-2-thiouracil  (EXP)
acrolein  (ISO)
actinomycin D  (ISO)
aflatoxin B1  (EXP)
aldehydo-D-glucose  (EXP,ISO)
all-trans-retinoic acid  (ISO)
alpha-pinene  (ISO)
aluminium atom  (EXP)
aluminium(0)  (EXP)
amiodarone  (EXP)
amitrole  (EXP)
ammonium chloride  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
aspartame  (ISO)
benzbromarone  (EXP)
benzo[a]pyrene  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
butylated hydroxyanisole  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chlorpyrifos  (ISO)
clofibrate  (EXP)
clofibric acid  (EXP)
cobalt atom  (ISO)
cobalt dichloride  (EXP)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) chloride  (ISO)
coumarin  (EXP)
cyclosporin A  (ISO)
cyproconazole  (EXP)
D-glucose  (EXP,ISO)
decabromodiphenyl ether  (ISO)
desferrioxamine B  (EXP,ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
diazinon  (ISO)
diethylstilbestrol  (EXP)
dioxygen  (EXP)
doxorubicin  (EXP,ISO)
endosulfan  (EXP)
epoxiconazole  (EXP)
etoposide  (ISO)
fenofibrate  (EXP)
ferric ammonium citrate  (ISO)
Fluorocitric acid  (EXP)
flutamide  (EXP)
folic acid  (ISO)
fulvestrant  (ISO)
furan  (EXP)
gallium nitrate  (ISO)
glucose  (EXP,ISO)
gold atom  (ISO)
gold(0)  (ISO)
hemin  (EXP)
hydrogen peroxide  (ISO)
indometacin  (EXP)
iron atom  (EXP,ISO)
iron(0)  (EXP,ISO)
iron(2+) sulfate (anhydrous)  (ISO)
iron(3+) sulfate  (ISO)
isoniazide  (ISO)
isotretinoin  (ISO)
ivermectin  (ISO)
KN-93  (EXP)
L-ethionine  (EXP)
lead nitrate  (ISO)
leflunomide  (EXP)
linalool  (ISO)
lipopolysaccharide  (ISO)
manganese atom  (EXP,ISO)
manganese(0)  (EXP,ISO)
manganese(II) chloride  (EXP)
menadione  (ISO)
Mesaconitine  (EXP)
methamphetamine  (EXP)
methapyrilene  (EXP,ISO)
methimazole  (EXP)
miconazole  (ISO)
mitomycin C  (ISO)
monosodium L-glutamate  (ISO)
Muraglitazar  (EXP)
N-nitrosodimethylamine  (EXP)
nefazodone  (EXP)
nickel atom  (ISO)
nickel dichloride  (ISO)
nickel sulfate  (ISO)
nimesulide  (EXP)
nitric oxide  (ISO)
Nutlin-3  (ISO)
okadaic acid  (EXP)
omeprazole  (EXP)
oxidopamine  (ISO)
ozone  (ISO)
p-toluidine  (EXP)
paracetamol  (ISO)
paraquat  (EXP,ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP)
Pervanadate  (EXP)
phenobarbital  (ISO)
phlorizin  (ISO)
phorbol 13-acetate 12-myristate  (EXP,ISO)
piperonyl butoxide  (EXP)
pirinixic acid  (EXP)
prochloraz  (EXP)
propiconazole  (EXP)
protein kinase inhibitor  (ISO)
quercetin  (EXP)
rotenone  (ISO)
sodium arsenite  (EXP)
Soman  (EXP)
sulfadimethoxine  (EXP)
superoxide  (ISO)
temozolomide  (ISO)
tert-butyl hydroperoxide  (ISO)
Tesaglitazar  (EXP)
tetrachloromethane  (EXP,ISO)
thapsigargin  (EXP)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
trabectedin  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
triphenyl phosphate  (EXP)
triptonide  (ISO)
troglitazone  (EXP)
valdecoxib  (EXP)
valproic acid  (ISO)
vanadium atom  (ISO)
vanadium(0)  (ISO)
vinclozolin  (EXP)
zearalenone  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IEA,ISO)
cytosol  (IBA,IEA,ISO)
endoplasmic reticulum  (IEA,ISO)
Golgi apparatus  (IDA,IEA,ISO)
mitochondrion  (IBA)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Induction of aconitate hydratase in hepatocytes of starving rats. Eprintsev AT, etal., Biochemistry (Mosc) 2002 Jul;67(7):795-801.
2. The role of iron in anthracycline cardiotoxicity. Gammella E, etal., Front Pharmacol. 2014 Feb 26;5:25. doi: 10.3389/fphar.2014.00025. eCollection 2014.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. Exercise decreases cytosolic aconitase activity in the liver, spleen, and bone marrow in rats. Ho KP, etal., Biochem Biophys Res Commun. 2001 Mar 23;282(1):264-7.
6. Role of iron in the pathogenesis of cysteamine-induced duodenal ulceration in rats. Khomenko T, etal., Am J Physiol Gastrointest Liver Physiol. 2009 Jun;296(6):G1277-86. doi: 10.1152/ajpgi.90257.2008. Epub 2009 Apr 2.
7. Cellular iron uptake, trafficking and metabolism: Key molecules and mechanisms and their roles in disease. Lane DJ, etal., Biochim Biophys Acta. 2015 May;1853(5):1130-44. doi: 10.1016/j.bbamcr.2015.01.021. Epub 2015 Feb 4.
8. Disrupted iron metabolism and ensuing oxidative stress may mediate cognitive dysfunction induced by chronic cerebral hypoperfusion. Li Y, etal., Biol Trace Elem Res. 2012 Dec;150(1-3):242-8. doi: 10.1007/s12011-012-9455-0. Epub 2012 May 26.
9. Foot-shock stress-induced regional iron accumulation and altered iron homeostatic mechanisms in rat brain. Ma L, etal., Biol Trace Elem Res. 2008 Winter;126(1-3):204-13. doi: 10.1007/s12011-008-8197-5. Epub 2008 Aug 16.
10. Developmental changes of rat liver cytoplasmic and mitochondrial aconitate hydratases. Masini A, etal., Ital J Biochem. 1978 Sep-Oct;27(5):300-4.
11. High Fat Diet Induces Liver Steatosis and Early Dysregulation of Iron Metabolism in Rats. Meli R, etal., PLoS One. 2013 Jun 21;8(6):e66570. doi: 10.1371/journal.pone.0066570. Print 2013.
12. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
13. IRP1 activity and expression are increased in the liver and the spleen of rats fed fish oil-rich diets and are related to oxidative stress. Miret S, etal., J Nutr. 2003 Apr;133(4):999-1003.
14. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
15. Subcellular localization of iron regulatory proteins to Golgi and ER membranes. Patton SM, etal., J Cell Sci. 2005 Oct 1;118(Pt 19):4365-73. Epub 2005 Sep 6.
16. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
17. IF/TA-related metabolic changes--proteome analysis of rat renal allografts. Reuter S, etal., Nephrol Dial Transplant. 2010 Aug;25(8):2492-501. doi: 10.1093/ndt/gfq043. Epub 2010 Feb 22.
18. GOA pipeline RGD automated data pipeline
19. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
20. The iron-sulfur cluster of iron regulatory protein 1 modulates the accessibility of RNA binding and phosphorylation sites. Schalinske KL, etal., Biochemistry. 1997 Apr 1;36(13):3950-8.
21. Rat duodenal IRP1 activity and iron absorption in iron deficiency and after HO perfusion. Schumann K, etal., Eur J Clin Invest. 2004 Apr;34(4):275-82.
22. Molecular pharmacology of the interaction of anthracyclines with iron. Xu X, etal., Mol Pharmacol. 2005 Aug;68(2):261-71. Epub 2005 May 9.
23. The iron-responsive element binding protein. Purification, cloning, and regulation in rat liver. Yu Y, etal., J Biol Chem 1992 Sep 15;267(26):19005-10.
Additional References at PubMed
PMID:1281544   PMID:1946430   PMID:8041788   PMID:8262972   PMID:14726953   PMID:15604406   PMID:15625891   PMID:15629469   PMID:16198227   PMID:16407072   PMID:16527810   PMID:18005658  
PMID:18177727   PMID:18614015   PMID:19056867   PMID:22544036   PMID:22585610   PMID:22871113   PMID:22900282   PMID:23087176   PMID:23376485   PMID:23376588   PMID:23533145   PMID:23891004  
PMID:24601712   PMID:25106854   PMID:25652229   PMID:27914013  


Genomics

Comparative Map Data
Aco1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8560,055,895 - 60,111,920 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl560,055,866 - 60,112,600 (+)EnsemblGRCr8
mRatBN7.2555,259,841 - 55,315,872 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl555,259,827 - 55,316,391 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx557,225,306 - 57,281,119 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0559,044,439 - 59,100,254 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0559,015,833 - 59,071,688 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0556,425,076 - 56,481,218 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl556,425,024 - 56,481,218 (+)Ensemblrn6Rnor6.0
Rnor_5.0560,972,013 - 61,027,705 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4557,536,675 - 57,591,765 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera553,878,712 - 53,934,197 (+)NCBICelera
RGSC_v3.1557,536,853 - 57,591,944 (+)NCBI
Cytogenetic Map5q22NCBI
ACO1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38932,384,643 - 32,454,769 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl932,384,603 - 32,454,769 (+)Ensemblhg38GRCh38
GRCh37932,384,641 - 32,454,767 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36932,374,650 - 32,440,830 (+)NCBIBuild 36Build 36hg18NCBI36
Build 34932,374,649 - 32,440,830NCBI
Celera932,314,541 - 32,380,796 (+)NCBICelera
Cytogenetic Map9p21.1ENTREZGENE
HuRef932,340,337 - 32,406,624 (+)NCBIHuRef
CHM1_1932,384,455 - 32,450,692 (+)NCBICHM1_1
T2T-CHM13v2.0932,400,543 - 32,470,694 (+)NCBIT2T-CHM13v2.0
Aco1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39440,143,429 - 40,199,011 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl440,143,081 - 40,198,338 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38440,143,265 - 40,199,009 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl440,143,081 - 40,198,338 (+)Ensemblmm10GRCm38
MGSCv37440,090,298 - 40,146,042 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36440,328,401 - 40,386,991 (+)NCBIMGSCv36mm8
Celera439,806,276 - 39,861,986 (+)NCBICelera
Cytogenetic Map4A5NCBI
cM Map420.24NCBI
Aco1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554723,141,257 - 3,170,959 (-)Ensembl
ChiLan1.0NW_0049554723,141,473 - 3,170,959 (-)NCBIChiLan1.0ChiLan1.0
ACO1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21192,164,213 - 92,231,743 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1992,170,253 - 92,237,579 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0932,157,763 - 32,225,116 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1932,967,993 - 33,035,177 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl932,967,993 - 33,035,177 (+)EnsemblpanPan2panpan1.1
ACO1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11149,699,072 - 49,758,783 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1149,699,109 - 49,923,257 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1148,322,141 - 48,381,344 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01150,638,076 - 50,697,301 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1150,638,068 - 50,698,739 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11149,303,601 - 49,362,955 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01149,170,094 - 49,229,515 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01149,928,796 - 49,988,168 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Aco1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947164,534,060 - 164,592,528 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365241,081,696 - 1,134,971 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365241,081,672 - 1,134,971 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ACO1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1033,937,833 - 34,001,900 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11033,937,833 - 34,001,895 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21038,194,977 - 38,259,631 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ACO1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11247,771,140 - 47,874,478 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1247,806,436 - 47,874,227 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366603844,664,516 - 44,768,114 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Aco1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473637,063,246 - 37,126,702 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462473637,063,540 - 37,127,772 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Aco1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11118,012,975 - 118,068,196 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Aco1
400 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:413
Count of miRNA genes:225
Interacting mature miRNAs:257
Transcripts:ENSRNOT00000008337
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1578776Stresp18Stress response QTL 182.9thymus mass (VT:0004954)thymus wet weight (CMO:0000855)53275164977751649Rat
1298067Scl15Serum cholesterol level QTL 154.80.001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)53801167083011670Rat
1300115Hrtrt7Heart rate QTL 72.76heart pumping trait (VT:2000009)heart rate (CMO:0000002)55266537294894052Rat
6907115Mcs29Mammary carcinoma susceptibility QTL 29mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)53800433183004331Rat
1549845Scl44Serum cholesterol level QTL 446blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)544924861153890773Rat
1358353Srcrtb2Stress Responsive Cort Basal QTL 23.480.003blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)52367149379046465Rat
70212Niddm25Non-insulin dependent diabetes mellitus QTL 253.54blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)538207390136631402Rat
634305Mamtr1Mammary tumor resistance QTL 10.0001mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)51757663362576633Rat
1331801Rf33Renal function QTL 334.149kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)548523123134369373Rat
1578774Tcas8Tongue tumor susceptibility QTL 83.47tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)51570745160707451Rat
1598807Glom12Glomerulus QTL 122.7kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)53801167083011670Rat
1302786Kidm8Kidney mass QTL 828.15kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)53801167083011670Rat
1331782Rf36Renal function QTL 363.296kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)539019942102105896Rat
6903292Stl28Serum triglyceride level QTL 282.60.0073blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)53331167378311673Rat
1578766Tcas11Tongue tumor susceptibility QTL 114.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)551657967166600247Rat
1578767Stresp17Stress response QTL 174.30.01blood aldosterone amount (VT:0005346)plasma aldosterone level (CMO:0000551)53275164977751649Rat
1641922Alcrsp8Alcohol response QTL 8alcohol metabolism trait (VT:0015089)blood ethanol level (CMO:0000535)51748608062486080Rat
1576312Emca8Estrogen-induced mammary cancer QTL 84.1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)555124766172190305Rat
1641912Alcrsp18Alcohol response QTL 18response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)53998594884985948Rat
1576314Eutr1Estrogen induced uterine response QTL 1uterus integrity trait (VT:0010575)pyometritis severity score (CMO:0002009)5692228281330203Rat
6903306Scl35Serum cholesterol QTL 352.60.0073blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)53331167378311673Rat
1576317Eutr2Estrogen induced uterine response QTL 20.01uterus integrity trait (VT:0010575)pyometritis severity score (CMO:0002009)53952692484526924Rat
1331773Scl26Serum cholesterol level QTL 263.065blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)54852312391770353Rat
1331771Rf35Renal function QTL 354.36965kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)51001906491770353Rat
8662454Vetf3Vascular elastic tissue fragility QTL 327.4artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)5706553574335773Rat
2290448Scl54Serum cholesterol level QTL 542.93blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)536460764136631402Rat
1641903Alcrsp3Alcohol response QTL 3response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)51748608062486080Rat
1331756Rf34Renal function QTL 344.16275kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)51001906487027358Rat
8552954Pigfal14Plasma insulin-like growth factor 1 level QTL 149blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)52602321171023211Rat
2303577Gluco47Glucose level QTL 473blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)51652001961520019Rat
2316959Gluco59Glucose level QTL 594.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)556546393101546393Rat
1600358Mamtr5Mammary tumor resistance QTL 5mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)52367149368671493Rat

Markers in Region
RH127730  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2555,315,609 - 55,315,814 (+)MAPPERmRatBN7.2
Rnor_6.0556,480,960 - 56,481,164NCBIRnor6.0
Rnor_5.0561,027,447 - 61,027,651UniSTSRnor5.0
RGSC_v3.4557,591,507 - 57,591,711UniSTSRGSC3.4
Celera553,933,939 - 53,934,143UniSTS
Cytogenetic Map5q22UniSTS
RH129206  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2555,315,623 - 55,315,818 (+)MAPPERmRatBN7.2
Rnor_6.0556,480,974 - 56,481,168NCBIRnor6.0
Rnor_5.0561,027,461 - 61,027,655UniSTSRnor5.0
RGSC_v3.4557,591,521 - 57,591,715UniSTSRGSC3.4
Celera553,933,953 - 53,934,147UniSTS
Cytogenetic Map5q22UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000008337   ⟹   ENSRNOP00000008337
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl560,055,866 - 60,112,600 (+)Ensembl
mRatBN7.2 Ensembl555,259,827 - 55,315,872 (+)Ensembl
Rnor_6.0 Ensembl556,425,024 - 56,481,218 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000100040   ⟹   ENSRNOP00000078636
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl560,055,866 - 60,112,600 (+)Ensembl
mRatBN7.2 Ensembl555,259,827 - 55,316,391 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000122475   ⟹   ENSRNOP00000099129
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl560,055,866 - 60,111,143 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000123123   ⟹   ENSRNOP00000103680
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl560,055,866 - 60,111,439 (+)Ensembl
RefSeq Acc Id: NM_017321   ⟹   NP_059017
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8560,055,895 - 60,111,920 (+)NCBI
mRatBN7.2555,259,841 - 55,315,872 (+)NCBI
Rnor_6.0556,425,076 - 56,481,218 (+)NCBI
Rnor_5.0560,972,013 - 61,027,705 (+)NCBI
RGSC_v3.4557,536,675 - 57,591,765 (+)RGD
Celera553,878,712 - 53,934,197 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_059017 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000078636
GenBank Protein Q63270 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_059017   ⟸   NM_017321
- UniProtKB: Q63270 (UniProtKB/Swiss-Prot),   A6IIQ7 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000008337   ⟸   ENSRNOT00000008337
Ensembl Acc Id: ENSRNOP00000078636   ⟸   ENSRNOT00000100040
Ensembl Acc Id: ENSRNOP00000099129   ⟸   ENSRNOT00000122475
Ensembl Acc Id: ENSRNOP00000103680   ⟸   ENSRNOT00000123123
Protein Domains
Aconitase A/isopropylmalate dehydratase small   Aconitase/3-isopropylmalate dehydratase large

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q63270-F1-model_v2 AlphaFold Q63270 1-889 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13693627
Promoter ID:EPDNEW_R4152
Type:initiation region
Name:Aco1_1
Description:aconitase 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0556,425,070 - 56,425,130EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2019 AgrOrtholog
BioCyc Gene G2FUF-41607 BioCyc
BioCyc Pathway PWY-5690 [TCA cycle II (plants and fungi)] BioCyc
BioCyc Pathway Image PWY-5690 BioCyc
Ensembl Genes ENSRNOG00000005849 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000100040 ENTREZGENE
Gene3D-CATH 3.20.19.10 UniProtKB/Swiss-Prot
  3.30.499.10 UniProtKB/Swiss-Prot
  6.10.190.10 UniProtKB/Swiss-Prot
InterPro AcnA_IRP_Swivel UniProtKB/Swiss-Prot
  Acnase/IPM_dHydase_lsu_aba_1/3 UniProtKB/Swiss-Prot
  Acoase/IPM_deHydtase_lsu_aba UniProtKB/Swiss-Prot
  Aconitase/3IPM_dehydase_swvl UniProtKB/Swiss-Prot
  Aconitase/IRP2 UniProtKB/Swiss-Prot
  Aconitase_4Fe-4S_BS UniProtKB/Swiss-Prot
  Aconitase_4Fe-4S_dom UniProtKB/Swiss-Prot
  AconitaseA/IPMdHydase_ssu_swvl UniProtKB/Swiss-Prot
KEGG Report rno:50655 UniProtKB/Swiss-Prot
NCBI Gene Aco1 ENTREZGENE
PANTHER PTHR11670 UniProtKB/Swiss-Prot
Pfam Aconitase UniProtKB/Swiss-Prot
  Aconitase_C UniProtKB/Swiss-Prot
PhenoGen Aco1 PhenoGen
PRINTS ACONITASE UniProtKB/Swiss-Prot
PROSITE ACONITASE_1 UniProtKB/Swiss-Prot
  ACONITASE_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000005849 RatGTEx
Superfamily-SCOP LeuD/IlvD-like UniProtKB/Swiss-Prot
  SSF53732 UniProtKB/Swiss-Prot
UniProt A0A8I5ZLC2_RAT UniProtKB/TrEMBL
  A0ABK0L8J4_RAT UniProtKB/TrEMBL
  A0ABK0LJI5_RAT UniProtKB/TrEMBL
  A6IIQ7 ENTREZGENE, UniProtKB/TrEMBL
  ACOC_RAT UniProtKB/Swiss-Prot
  G3V6S2_RAT UniProtKB/TrEMBL
  Q63270 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-12-09 Aco1  aconitase 1  Aco1  aconitase 1, soluble  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-09 Aco1  aconitase 1, soluble  Aco1  aconitase 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-12-14 Aco1  aconitase 1  Ratireb  iron-responsive element-binding protein  Data merged from RGD:621624 737654 APPROVED
2002-11-06 Aco1  aconitase 1    Aconitase 1, soluble  Name updated 625702 APPROVED
2002-08-07 Ratireb  iron-responsive element-binding protein      Symbol and Name status set to provisional 70820 PROVISIONAL
2002-06-10 Aco1  Aconitase 1, soluble      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_homology shows 95% identity with human IRE-BP and 98% identity with mouse IRE-BP 633751