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Gene: Lmtk2 (lemur tyrosine kinase 2) Rattus norvegicus

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Symbol:

Lmtk2

Name:

lemur tyrosine kinase 2

RGD ID:

1598332

Description:

Predicted to enable myosin VI binding activity; protein phosphatase inhibitor activity; and protein serine/threonine kinase activity. Predicted to be involved in endosomal transport; receptor recycling; and transferrin transport. Located in growth cone and neuronal cell body. Orthologous to human LMTK2 (lemur tyrosine kinase 2); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 3,4-methylenedioxymethamphetamine; aflatoxin B1.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

LOC304286; serine/threonine-protein kinase LMTK2; similar to lemur tyrosine kinase 2

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	LMTK2 (lemur tyrosine kinase 2)	HGNC	Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, Panther, Treefam
Mus musculus (house mouse):	Lmtk2 (lemur tyrosine kinase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Lmtk2 (lemur tyrosine kinase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	LMTK2 (lemur tyrosine kinase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	LMTK2 (lemur tyrosine kinase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Lmtk2 (lemur tyrosine kinase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	LMTK2 (lemur tyrosine kinase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	LMTK2 (lemur tyrosine kinase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Lmtk2 (lemur tyrosine kinase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus rattus (black rat):	Lmtk2 (lemur tyrosine kinase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	DNAJC30 (DnaJ heat shock protein family (Hsp40) member C30)	HGNC	OMA
Alliance orthologs ³
Homo sapiens (human):	LMTK2 (lemur tyrosine kinase 2)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Lmtk2 (lemur tyrosine kinase 2)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	lmtk2 (lemur tyrosine kinase 2)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	lmtk2	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	gbx2.2	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PhylomeDB\|SonicParanoid)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	12	15,540,428 - 15,622,392 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	12	15,540,428 - 15,622,392 (-)	Ensembl				GRCr8
mRatBN7.2	12	10,426,772 - 10,508,750 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	12	10,426,777 - 10,508,750 (-)	Ensembl				mRatBN7.2
Rnor_6.0	12	12,409,876 - 12,546,111 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	12	12,409,876 - 12,546,111 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	12	14,461,531 - 14,592,856 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	12	10,754,175 - 10,836,896 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	12	12,225,898 - 12,307,097 (-)	NCBI		Celera
Cytogenetic Map	12	p11	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Prostatic Neoplasms (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(1->4)-beta-D-glucan (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2-hydroxypropanoic acid (ISO)

3,4-methylenedioxymethamphetamine (EXP,ISO)

3-methylcholanthrene (ISO)

4,4'-sulfonyldiphenol (ISO)

aflatoxin B1 (EXP)

arsenite(3-) (ISO)

benzo[a]pyrene (ISO)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (EXP,ISO)

cadmium atom (EXP)

cadmium dichloride (EXP,ISO)

caffeine (ISO)

carbon nanotube (ISO)

carmustine (ISO)

chlorpyrifos (ISO)

choline (ISO)

cobalt dichloride (ISO)

copper atom (ISO)

copper(0) (ISO)

copper(II) sulfate (ISO)

Cuprizon (EXP)

decabromodiphenyl ether (EXP)

Dibutyl phosphate (ISO)

dicrotophos (ISO)

disulfiram (ISO)

ethanol (ISO)

fenthion (ISO)

folic acid (ISO)

FR900359 (ISO)

gentamycin (EXP)

L-methionine (ISO)

leflunomide (ISO)

methyl methanesulfonate (ISO)

miconazole (ISO)

mono(2-ethylhexyl) phthalate (ISO)

oxaliplatin (EXP)

ozone (ISO)

paracetamol (EXP)

perfluorooctane-1-sulfonic acid (ISO)

rac-lactic acid (ISO)

sodium arsenite (ISO)

temozolomide (ISO)

thioacetamide (EXP)

thiram (ISO)

titanium dioxide (ISO)

topotecan (EXP)

trimellitic anhydride (ISO)

triphenyl phosphate (ISO)

tungsten (ISO)

urethane (ISO)

valproic acid (EXP,ISO)

vinclozolin (EXP)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

early endosome to late endosome transport (IEA,ISO)

endocytic recycling (IBA,IEA,ISO)

peptidyl-serine phosphorylation (ISO)

peptidyl-threonine phosphorylation (ISO)

protein autophosphorylation (ISO)

protein phosphorylation (ISO)

receptor recycling (IEA,ISO)

transferrin transport (IEA,ISO)

Cellular Component

cytoplasm (IEA)

early endosome (IEA,ISO)

endomembrane system (IEA)

Golgi apparatus (IEA,ISO)

growth cone (IDA)

membrane (IEA,ISO)

neuronal cell body (IDA)

perinuclear region of cytoplasm (IEA,ISO)

recycling endosome (IEA,ISO)

Molecular Function

ATP binding (IEA)

kinase activity (IEA)

myosin VI binding (IEA,ISO)

nucleotide binding (IEA)

protein binding (ISO)

protein kinase activity (IBA,IEA)

protein phosphatase inhibitor activity (IEA,ISO)

protein serine/threonine kinase activity (IEA,ISO)

transferase activity (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Identification of a novel, membrane-associated neuronal kinase, cyclin-dependent kinase 5/p35-regulated kinase.	Kesavapany S, etal., J Neurosci. 2003 Jun 15;23(12):4975-83.
3.	GOA pipeline	RGD automated data pipeline
4.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:12393858	PMID:16887929	PMID:18029400	PMID:18429820

Genomics

Comparative Map Data

Lmtk2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	12	15,540,428 - 15,622,392 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	12	15,540,428 - 15,622,392 (-)	Ensembl				GRCr8
mRatBN7.2	12	10,426,772 - 10,508,750 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	12	10,426,777 - 10,508,750 (-)	Ensembl				mRatBN7.2
Rnor_6.0	12	12,409,876 - 12,546,111 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	12	12,409,876 - 12,546,111 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	12	14,461,531 - 14,592,856 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	12	10,754,175 - 10,836,896 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	12	12,225,898 - 12,307,097 (-)	NCBI		Celera
Cytogenetic Map	12	p11	NCBI

LMTK2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	7	98,106,862 - 98,209,638 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	7	98,106,860 - 98,209,638 (+)	Ensembl			hg38	GRCh38
GRCh37	7	97,736,174 - 97,838,950 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	7	97,574,133 - 97,673,537 (+)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	7	97,380,847 - 97,480,252	NCBI
Celera	7	92,430,124 - 92,532,844 (+)	NCBI		Celera
Cytogenetic Map	7	q21.3	NCBI
HuRef	7	92,337,056 - 92,439,783 (+)	NCBI		HuRef
CHM1_1	7	97,666,229 - 97,768,960 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	7	99,335,937 - 99,439,778 (+)	NCBI		T2T-CHM13v2.0
CRA_TCAGchr7v2	7	97,061,094 - 97,163,823 (+)	NCBI

Lmtk2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	5	144,037,179 - 144,125,026 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	5	144,037,254 - 144,125,022 (+)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	5	144,100,361 - 144,188,208 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	5	144,100,436 - 144,188,204 (+)	Ensembl			mm10	GRCm38
MGSCv37	5	144,861,305 - 144,949,073 (+)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	5	144,353,963 - 144,441,731 (+)	NCBI		MGSCv36	mm8
Celera	5	141,085,346 - 141,172,582 (+)	NCBI		Celera
Cytogenetic Map	5	G2	NCBI
cM Map	5	82.85	NCBI

Lmtk2
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955460	14,012,363 - 14,098,542 (+)	Ensembl
ChiLan1.0	NW_004955460	14,012,047 - 14,101,969 (+)	NCBI	ChiLan1.0	ChiLan1.0

LMTK2
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	6	115,953,467 - 116,056,231 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	7	164,217,941 - 164,320,868 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	7	6,312,634 - 6,415,332 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	7	103,572,011 - 103,672,453 (+)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	7	103,572,011 - 103,672,453 (+)	Ensembl			panPan2	panpan1.1

LMTK2
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	6	11,118,110 - 11,201,624 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	6	11,118,635 - 11,201,460 (-)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	6	12,743,572 - 12,827,412 (-)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	6	11,117,646 - 11,201,655 (-)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	6	11,118,557 - 11,201,640 (-)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	6	10,986,346 - 11,070,342 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	6	10,966,165 - 11,050,164 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	6	11,200,210 - 11,284,268 (-)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Lmtk2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024409344	139,193,757 - 139,258,321 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936750	686,883 - 752,567 (+)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936750	665,410 - 751,529 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

LMTK2
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	3	5,322,255 - 5,409,171 (+)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	3	5,322,238 - 5,409,223 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	3	5,428,088 - 5,468,507 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

LMTK2
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	28	14,961,397 - 15,067,423 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	28	14,959,280 - 15,067,364 (-)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666070	1,009,422 - 1,118,107 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Lmtk2
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624740	31,581,464 - 31,671,570 (+)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624740	31,581,185 - 31,669,852 (+)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Lmtk2
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	16	9,006,194 - 9,087,336 (-)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Lmtk2
889 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	507
Count of miRNA genes:	263
Interacting mature miRNAs:	341
Transcripts:	ENSRNOT00000046381
Prediction methods:	Miranda, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
2312418	Kidm41	Kidney mass QTL 41	3.7	0.0001	kidney mass (VT:0002707)	single kidney wet weight to body weight ratio (CMO:0000622)	12	5921918	25247790	Rat
70213	Niddm27	Non-insulin dependent diabetes mellitus QTL 27	3.72		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	12	11200494	52308831	Rat
2306789	Ean6	Experimental allergic neuritis QTL 6	4.9		nervous system integrity trait (VT:0010566)	experimental autoimmune neuritis severity score (CMO:0001528)	12	1	29775522	Rat
8552964	Pigfal17	Plasma insulin-like growth factor 1 level QTL 17	3.5		blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	12	11200494	52308831	Rat
7411641	Foco19	Food consumption QTL 19	27.7	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	12	11200494	52308831	Rat
1357337	Gluco3	Glucose level QTL 3		0.0004	adipocyte glucose uptake trait (VT:0004185)	absolute change in adipocyte glucose uptake (CMO:0000873)	12	1	16966671	Rat
5684888	Pia42	Pristane induced arthritis QTL 42			joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	12	3489416	48489416	Rat
1331739	Hrtrt14	Heart rate QTL 14	3.56232		heart pumping trait (VT:2000009)	heart rate (CMO:0000002)	12	1	38687564	Rat
8552912	Pigfal6	Plasma insulin-like growth factor 1 level QTL 6	5		blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	12	11200497	52308831	Rat
1549829	Scl48	Serum cholesterol level QTL 48	5		blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	12	15264248	52308831	Rat
61331	Eau2	Experimental allergic uveoretinitis QTL 2		0.0005	uvea integrity trait (VT:0010551)	experimental autoimmune uveitis score (CMO:0001504)	12	1	33700600	Rat
10059594	Kidm46	Kidney mass QTL 46	3.79	0.025	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	12	11743528	52308831	Rat
8552918	Pigfal7	Plasma insulin-like growth factor 1 level QTL 7			blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	12	11200494	52308831	Rat
1581516	Cm56	Cardiac mass QTL 56	4.2	0.05	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	12	11869600	16966542	Rat
61334	Gluco17	Glucose level QTL 17	6.3		adipocyte glucose uptake trait (VT:0004185)	adipocyte maximal glucose uptake to basal glucose uptake ratio (CMO:0000874)	12	1	16966671	Rat
2293684	Bmd26	Bone mineral density QTL 26	4.4	0.0002	femur mineral mass (VT:0010011)	total volumetric bone mineral density (CMO:0001728)	12	1	38635130	Rat
6893681	Bw109	Body weight QTL 109	2.3	0.004	body mass (VT:0001259)	body weight (CMO:0000012)	12	1	28133365	Rat
1302792	Scl21	Serum cholesterol level QTL 21	3.8	0.0011	blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	12	12233000	30490641	Rat
1300174	Bw15	Body weight QTL 15	2.93		body mass (VT:0001259)	body weight loss (CMO:0001399)	12	1	28606299	Rat
1331787	Rf41	Renal function QTL 41	2.998		kidney blood vessel physiology trait (VT:0100012)	absolute change in renal blood flow rate (CMO:0001168)	12	1	33700556	Rat
1331763	Wbc2	White blood cell count QTL 2	3.162		leukocyte quantity (VT:0000217)	total white blood cell count (CMO:0000365)	12	11200494	52308831	Rat
7204484	Bp358	Blood pressure QTL 358		0.001	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	12	1	24849755	Rat
7411547	Bw129	Body weight QTL 129		0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	6	11200494	52308831	Rat
7387292	Kidm42	Kidney mass QTL 42	3.03	0.0004	kidney mass (VT:0002707)	left kidney wet weight (CMO:0000083)	12	1	41361854	Rat
1298081	Cia25	Collagen induced arthritis QTL 25	4.7		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	12	2747694	47747694	Rat
2303568	Bw88	Body weight QTL 88	3		body mass (VT:0001259)	body weight (CMO:0000012)	12	1	28606299	Rat
2303575	Insul14	Insulin level QTL 14	4		blood insulin amount (VT:0001560)	blood insulin level (CMO:0000349)	12	3087180	48087180	Rat
7411588	Foco6	Food consumption QTL 6		0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	12	11200494	52308831	Rat
7243862	Mcs30	Mammary carcinoma susceptibility QTL 30	8.62		mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	12	5633306	50633306	Rat
2293086	Iddm30	Insulin dependent diabetes mellitus QTL 30	3.82		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	12	7901625	33938215	Rat
7411597	Foco10	Food consumption QTL 10		0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	12	11200494	52308831	Rat

Markers in Region

RH137813

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	12	10,457,477 - 10,457,622 (+)	MAPPER	mRatBN7.2
Rnor_6.0	12	12,439,853 - 12,439,997	NCBI	Rnor6.0
Rnor_5.0	12	14,490,311 - 14,490,455	UniSTS	Rnor5.0
RGSC_v3.4	12	10,785,347 - 10,785,491	UniSTS	RGSC3.4
Celera	12	12,256,383 - 12,256,527	UniSTS
RH 3.4 Map	12	122.8	UniSTS
Cytogenetic Map	12	p11	UniSTS

BE117320

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	12	10,459,634 - 10,459,784 (+)	MAPPER	mRatBN7.2
Rnor_6.0	12	12,442,010 - 12,442,159	NCBI	Rnor6.0
Rnor_5.0	12	14,492,468 - 14,492,617	UniSTS	Rnor5.0
RGSC_v3.4	12	10,787,504 - 10,787,653	UniSTS	RGSC3.4
Celera	12	12,258,540 - 12,258,689	UniSTS
RH 3.4 Map	12	121.7	UniSTS
Cytogenetic Map	12	p11	UniSTS

Lmtk2

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	12	10,427,023 - 10,428,055 (+)	MAPPER	mRatBN7.2
Rnor_6.0	12	12,410,123 - 12,411,154	NCBI	Rnor6.0
Rnor_5.0	12	14,461,778 - 14,462,809	UniSTS	Rnor5.0
RGSC_v3.4	12	10,754,422 - 10,755,453	UniSTS	RGSC3.4
Celera	12	12,226,145 - 12,227,176	UniSTS
Cytogenetic Map	12	p11	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
16	12	67	162	91	90	59	92	59	6	356	192	11	141	81	92	31	17	17

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001427236	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039089353	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039089354	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC126486	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH474012	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000012	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000046381 ⟹ ENSRNOP00000050872

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	12	15,540,428 - 15,622,392 (-)	Ensembl
mRatBN7.2 Ensembl	12	10,426,777 - 10,508,750 (-)	Ensembl
Rnor_6.0 Ensembl	12	12,409,876 - 12,546,111 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000092637

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	12	15,545,413 - 15,595,115 (-)	Ensembl
mRatBN7.2 Ensembl	12	10,431,758 - 10,481,463 (-)	Ensembl
Rnor_6.0 Ensembl	12	12,412,814 - 12,545,985 (-)	Ensembl

RefSeq Acc Id:

NM_001427236 ⟹ NP_001414165

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	12	15,540,428 - 15,622,392 (-)	NCBI

RefSeq Acc Id:

XM_039089353 ⟹ XP_038945281

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	12	15,540,428 - 15,622,392 (-)	NCBI
mRatBN7.2	12	10,426,772 - 10,508,750 (-)	NCBI

RefSeq Acc Id:

XM_039089354 ⟹ XP_038945282

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	12	15,540,428 - 15,622,392 (-)	NCBI
mRatBN7.2	12	10,426,772 - 10,508,750 (-)	NCBI

Protein Sequences


Protein RefSeqs	NP_001414165	(Get FASTA)	NCBI Sequence Viewer
	XP_038945281	(Get FASTA)	NCBI Sequence Viewer
	XP_038945282	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	EDL89639	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000050872
	ENSRNOP00000050872.4
	ENSRNOP00000083057
	ENSRNOP00000083057.1

Ensembl Acc Id:

ENSRNOP00000050872 ⟸ ENSRNOT00000046381

RefSeq Acc Id:	XP_038945282 ⟸ XM_039089354
- Peptide Label:	isoform X2
- UniProtKB:	A6K1I1 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038945281 ⟸ XM_039089353
- Peptide Label:	isoform X1
- UniProtKB:	A6K1I1 (UniProtKB/TrEMBL)

RefSeq Acc Id:	NP_001414165 ⟸ NM_001427236
- Peptide Label:	precursor
- UniProtKB:	A6K1I1 (UniProtKB/TrEMBL), D3ZBH5 (UniProtKB/TrEMBL)

Protein Domains

Protein kinase

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-D3ZBH5-F1-model_v2	AlphaFold	D3ZBH5	1-1531	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13698428

Promoter ID:

EPDNEW_R8953

Type:

multiple initiation site

Name:

Lmtk2_1

Description:

lemur tyrosine kinase 2

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	12	12,546,209 - 12,546,269	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1598332	AgrOrtholog
BioCyc Gene	G2FUF-20030	BioCyc
Ensembl Genes	ENSRNOG00000025155	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000046381	ENTREZGENE
	ENSRNOT00000046381.6	UniProtKB/TrEMBL
	ENSRNOT00000092637	ENTREZGENE
	ENSRNOT00000092637.3	UniProtKB/TrEMBL
Gene3D-CATH	Transferase(Phosphotransferase) domain 1	UniProtKB/TrEMBL
InterPro	Kinase-like_dom	UniProtKB/TrEMBL
	Prot_kinase_cat_dom	UniProtKB/TrEMBL
	Protein_kinase_ATP_BS	UniProtKB/TrEMBL
	Ser-Thr/Tyr-Pkinase	UniProtKB/TrEMBL
	Tyr_prot_kinase_AS	UniProtKB/TrEMBL
NCBI Gene	304286	ENTREZGENE
PANTHER	SERINE/THREONINE-PROTEIN KINASE LMTK1	UniProtKB/TrEMBL
	SERINE/THREONINE-PROTEIN KINASE LMTK2	UniProtKB/TrEMBL
Pfam	Pkinase_Tyr	UniProtKB/TrEMBL
PhenoGen	Lmtk2	PhenoGen
PRINTS	TYRKINASE	UniProtKB/TrEMBL
PROSITE	PROTEIN_KINASE_ATP	UniProtKB/TrEMBL
	PROTEIN_KINASE_DOM	UniProtKB/TrEMBL
	PROTEIN_KINASE_TYR	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000025155	RatGTEx
Superfamily-SCOP	Kinase_like	UniProtKB/TrEMBL
UniProt	A0A8I5ZW62_RAT	UniProtKB/TrEMBL
	A6K1I1	ENTREZGENE, UniProtKB/TrEMBL
	D3ZBH5	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2008-03-04	Lmtk2	lemur tyrosine kinase 2	LOC304286	similar to lemur tyrosine kinase 2	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2006-11-20	LOC304286	similar to lemur tyrosine kinase 2			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - CTD