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Gene: Gngt1 (G protein subunit gamma transducin 1) Rattus norvegicus
Analyze
Symbol:
Gngt1
Name:
G protein subunit gamma transducin 1
RGD ID:
1595475
Description:
Predicted to enable G-protein beta-subunit binding activity. Acts upstream of or within cardiac muscle cell apoptotic process and cellular response to hypoxia. Located in photoreceptor inner segment and photoreceptor outer segment. Part of heterotrimeric G-protein complex. Orthologous to human GNGT1 (G protein subunit gamma transducin 1); PARTICIPATES IN visual phototransduction pathway; chemokine mediated signaling pathway; glutamate signaling pathway; INTERACTS WITH bisphenol A; methoxychlor; 4,4'-sulfonyldiphenol (ortholog).
Type:
protein-coding
RefSeq Status:
PROVISIONAL
Previously known as:
guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1; guanine nucleotide binding protein, gamma transducing activity polypeptide 1; guanine nucleotide-binding protein G(T) subunit gamma-T1; heterotrimeric guanine nucleotide-binding protein 3g1; Hg3g1; LOC680149; similar to Guanine nucleotide-binding protein G(T) gamma-T1 subunit precursor (Transducin gamma chain)
RGD Orthologs
Alliance Orthologs
More Info
more info ...
More Info
Species
Gene symbol and name
Data Source
Assertion derived from
less info ...
Orthologs 1
Homo sapiens (human):
GNGT1 (G protein subunit gamma transducin 1)
HGNC
Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoMCL, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):
Gngt1 (guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1)
Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):
Gngt1 (G protein subunit gamma transducin 1)
Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):
GNGT1 (G protein subunit gamma transducin 1)
Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Canis lupus familiaris (dog):
GNGT1 (G protein subunit gamma transducin 1)
Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):
Gngt1 (G protein subunit gamma transducin 1)
Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Sus scrofa (pig):
GNGT1 (G protein subunit gamma transducin 1)
Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):
GNGT1 (G protein subunit gamma transducin 1)
Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):
Gngt1 (G protein subunit gamma transducin 1)
Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Rattus rattus (black rat):
Gngt1 (G protein subunit gamma transducin 1)
Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Other homologs 2
Homo sapiens (human):
GNG11 (G protein subunit gamma 11)
HGNC
OrthoDB
Alliance orthologs 3
Homo sapiens (human):
GNGT1 (G protein subunit gamma transducin 1)
Alliance
DIOPT (Ensembl Compara|HGNC|Hieranoid|InParanoid|OMA|OrthoFinder|OrthoInspector|PANTHER|PhylomeDB|SonicParanoid)
Mus musculus (house mouse):
Gngt1 (guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1)
Alliance
DIOPT (Ensembl Compara|Hieranoid|InParanoid|OMA|OrthoFinder|OrthoInspector|PANTHER|PhylomeDB|SonicParanoid)
Danio rerio (zebrafish):
gngt1 (guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1)
Alliance
DIOPT (Ensembl Compara|Hieranoid|InParanoid|OMA|OrthoFinder|OrthoInspector|PANTHER|PhylomeDB|SonicParanoid)
Drosophila melanogaster (fruit fly):
Ggamma1
Alliance
DIOPT (Ensembl Compara|OrthoFinder|PANTHER)
Xenopus tropicalis (tropical clawed frog):
gngt1
Alliance
DIOPT (Ensembl Compara|Hieranoid|InParanoid|OMA|OrthoFinder|OrthoInspector|PANTHER|PhylomeDB|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):
gngt1
Alliance
DIOPT (OMA|OrthoFinder|PANTHER|PhylomeDB)
Latest Assembly:
GRCr8 - GRCr8 Assembly
Position:
Rat Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl GRCr8 4 32,960,945 - 32,963,930 (+) NCBI GRCr8 GRCr8 GRCr8 GRCr8 Ensembl 4 32,960,945 - 32,963,930 (+) Ensembl GRCr8 mRatBN7.2 4 32,006,267 - 32,009,252 (+) NCBI mRatBN7.2 mRatBN7.2 mRatBN7.2 Ensembl 4 32,006,267 - 32,009,252 (+) Ensembl mRatBN7.2 UTH_Rnor_SHR_Utx 4 36,978,973 - 36,981,963 (+) NCBI UTH_Rnor_SHR_Utx UTH_Rnor_SHR_Utx UTH_Rnor_SHRSP_BbbUtx_1.0 4 32,905,099 - 32,908,089 (+) NCBI UTH_Rnor_SHRSP_BbbUtx_1.0 UTH_Rnor_SHRSP_BbbUtx_1.0 UTH_Rnor_WKY_Bbb_1.0 4 31,269,587 - 31,272,586 (+) NCBI UTH_Rnor_WKY_Bbb_1.0 UTH_Rnor_WKY_Bbb_1.0 Rnor_6.0 4 28,972,339 - 28,975,419 (+) NCBI Rnor_6.0 Rnor_6.0 rn6 Rnor6.0 Rnor_6.0 Ensembl 4 28,972,434 - 28,975,419 (+) Ensembl rn6 Rnor6.0 Rnor_5.0 4 28,880,061 - 28,883,215 (+) NCBI Rnor_5.0 Rnor_5.0 rn5 RGSC_v3.4 4 28,831,171 - 28,834,156 (+) NCBI RGSC_v3.4 RGSC_v3.4 rn4 Celera 4 27,392,552 - 27,395,537 (+) NCBI Celera Cytogenetic Map 4 q13 NCBI
JBrowse:
Imported Disease Annotations - ClinVar
Imported Disease Annotations - CTD
Only show annotations with direct experimental evidence (0 objects hidden)
Gngt1 Rat 4,4'-sulfonyldiphenol increases expression ISO GNGT1 (Homo sapiens) 6480464 bisphenol S results in increased expression of GNGT1 mRNA CTD PMID:34979203 Gngt1 Rat acrylamide increases expression ISO GNGT1 (Homo sapiens) 6480464 Acrylamide results in increased expression of GNGT1 mRNA CTD PMID:32763439 Gngt1 Rat aflatoxin B1 decreases methylation ISO GNGT1 (Homo sapiens) 6480464 Aflatoxin B1 results in decreased methylation of GNGT1 gene CTD PMID:27153756 Gngt1 Rat all-trans-retinoic acid increases expression ISO GNGT1 (Homo sapiens) 6480464 Tretinoin results in increased expression of GNGT1 mRNA CTD PMID:23724009 Gngt1 Rat arsane affects methylation ISO GNGT1 (Homo sapiens) 6480464 Arsenic affects the methylation of GNGT1 gene CTD PMID:25304211 Gngt1 Rat arsenic atom affects methylation ISO GNGT1 (Homo sapiens) 6480464 Arsenic affects the methylation of GNGT1 gene CTD PMID:25304211 Gngt1 Rat barium(0) multiple interactions ISO GNGT1 (Homo sapiens) 6480464 [GNB1 protein binds to GNGT1 protein] inhibits the reaction [CACNA1B protein results in increased transport more ... CTD PMID:11007869 Gngt1 Rat bis(2-ethylhexyl) phthalate multiple interactions ISO Gngt1 (Mus musculus) 6480464 Diethylhexyl Phthalate inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in decreased expression of more ... CTD PMID:33484791 Gngt1 Rat bisphenol A increases expression ISO Gngt1 (Mus musculus) 6480464 bisphenol A results in increased expression of GNGT1 mRNA CTD PMID:21932408 Gngt1 Rat bisphenol A affects methylation ISO Gngt1 (Mus musculus) 6480464 bisphenol A affects the methylation of GNGT1 promoter CTD PMID:27334623 Gngt1 Rat bisphenol A decreases expression EXP 6480464 bisphenol A results in decreased expression of GNGT1 mRNA CTD PMID:25181051 Gngt1 Rat carbon nanotube decreases expression ISO Gngt1 (Mus musculus) 6480464 Nanotubes, Carbon analog results in decreased expression of GNGT1 mRNA; Nanotubes, Carbon results in decreased more ... CTD PMID:25620056 Gngt1 Rat CGP 52608 multiple interactions ISO GNGT1 (Homo sapiens) 6480464 CGP 52608 promotes the reaction [RORA protein binds to GNGT1 gene] CTD PMID:28238834 Gngt1 Rat clothianidin decreases expression ISO GNGT1 (Homo sapiens) 6480464 clothianidin results in decreased expression of GNGT1 mRNA CTD PMID:31626844 Gngt1 Rat dorsomorphin multiple interactions ISO GNGT1 (Homo sapiens) 6480464 [NOG protein co-treated with trichostatin A co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased more ... CTD PMID:27188386 Gngt1 Rat entinostat increases expression ISO GNGT1 (Homo sapiens) 6480464 entinostat results in increased expression of GNGT1 mRNA CTD PMID:27188386 Gngt1 Rat iron dichloride increases expression ISO GNGT1 (Homo sapiens) 6480464 ferrous chloride results in increased expression of GNGT1 mRNA CTD PMID:35984750 Gngt1 Rat lipopolysaccharide multiple interactions ISO GNGT1 (Homo sapiens) 6480464 [S-(1,2-dichlorovinyl)cysteine affects the susceptibility to Lipopolysaccharides] which results in increased expression of GNGT1 mRNA; [S-(1,2-dichlorovinyl)cysteine more ... CTD PMID:35811015 Gngt1 Rat lipopolysaccharide increases expression ISO GNGT1 (Homo sapiens) 6480464 Lipopolysaccharides results in increased expression of GNGT1 mRNA CTD PMID:35811015 Gngt1 Rat mercury atom increases expression ISO GNGT1 (Homo sapiens) 6480464 Mercury results in increased expression of GNGT1 mRNA CTD PMID:16823088 Gngt1 Rat mercury(0) increases expression ISO GNGT1 (Homo sapiens) 6480464 Mercury results in increased expression of GNGT1 mRNA CTD PMID:16823088 Gngt1 Rat methoxychlor affects methylation EXP 6480464 Methoxychlor affects the methylation of GNGT1 gene CTD PMID:35440735 Gngt1 Rat paracetamol affects expression ISO Gngt1 (Mus musculus) 6480464 Acetaminophen affects the expression of GNGT1 mRNA CTD PMID:17562736 Gngt1 Rat perfluorononanoic acid increases expression ISO GNGT1 (Homo sapiens) 6480464 perfluoro-n-nonanoic acid results in increased expression of GNGT1 mRNA CTD PMID:25812627 Gngt1 Rat perfluorooctane-1-sulfonic acid increases expression ISO GNGT1 (Homo sapiens) 6480464 perfluorooctane sulfonic acid results in increased expression of GNGT1 mRNA CTD PMID:25812627 Gngt1 Rat pirinixic acid increases expression ISO Gngt1 (Mus musculus) 6480464 pirinixic acid results in increased expression of GNGT1 mRNA CTD PMID:18301758|PMID:23811191 Gngt1 Rat S-(1,2-dichlorovinyl)-L-cysteine multiple interactions ISO GNGT1 (Homo sapiens) 6480464 [S-(1,2-dichlorovinyl)cysteine affects the susceptibility to Lipopolysaccharides] which results in increased expression of GNGT1 mRNA; [S-(1,2-dichlorovinyl)cysteine more ... CTD PMID:35811015 Gngt1 Rat SB 431542 multiple interactions ISO GNGT1 (Homo sapiens) 6480464 [NOG protein co-treated with trichostatin A co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased more ... CTD PMID:27188386 Gngt1 Rat silicon dioxide increases expression ISO GNGT1 (Homo sapiens) 6480464 Silicon Dioxide analog results in increased expression of GNGT1 mRNA CTD PMID:23806026 Gngt1 Rat silicon dioxide decreases expression ISO Gngt1 (Mus musculus) 6480464 Silicon Dioxide results in decreased expression of GNGT1 mRNA CTD PMID:23221170 Gngt1 Rat streptozocin multiple interactions ISO Gngt1 (Mus musculus) 6480464 [Streptozocin co-treated with Dietary Fats] results in decreased expression of GNGT1 mRNA; Diethylhexyl Phthalate inhibits more ... CTD PMID:33484791 Gngt1 Rat tetrachloromethane decreases expression ISO Gngt1 (Mus musculus) 6480464 Carbon Tetrachloride results in decreased expression of GNGT1 mRNA CTD PMID:31919559 Gngt1 Rat trichostatin A multiple interactions ISO GNGT1 (Homo sapiens) 6480464 [NOG protein co-treated with trichostatin A co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased more ... CTD PMID:27188386 Gngt1 Rat trichostatin A increases expression ISO GNGT1 (Homo sapiens) 6480464 trichostatin A results in increased expression of GNGT1 mRNA CTD PMID:24935251|PMID:26272509|PMID:27188386 Gngt1 Rat tunicamycin increases expression ISO Gngt1 (Mus musculus) 6480464 Tunicamycin results in increased expression of GNGT1 mRNA CTD PMID:17127020 Gngt1 Rat valproic acid affects expression ISO Gngt1 (Mus musculus) 6480464 Valproic Acid affects the expression of GNGT1 mRNA CTD PMID:17292431 Gngt1 Rat valproic acid affects expression ISO GNGT1 (Homo sapiens) 6480464 Valproic Acid affects the expression of GNGT1 mRNA CTD PMID:25979313 Gngt1 Rat vorinostat multiple interactions ISO GNGT1 (Homo sapiens) 6480464 [NOG protein co-treated with Vorinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression more ... CTD PMID:27188386 Gngt1 Rat vorinostat increases expression ISO GNGT1 (Homo sapiens) 6480464 vorinostat results in increased expression of GNGT1 mRNA CTD PMID:26272509|PMID:27188386
Imported Annotations - KEGG (archival)
QTLs in Region (GRCr8)
2302371 Stl22 Serum triglyceride level QTL 22 5.15 blood triglyceride amount (VT:0002644) serum triglyceride level (CMO:0000360) 4 13080146 58080146 Rat 2303585 Bw86 Body weight QTL 86 4 body mass (VT:0001259) body weight (CMO:0000012) 4 15644309 60644309 Rat 8552906 Pigfal3 Plasma insulin-like growth factor 1 level QTL 3 blood insulin-like growth factor amount (VT:0010479) plasma insulin-like growth factor 1 level (CMO:0001299) 4 11038706 56038706 Rat 1357341 Gluco5 Glucose level QTL 5 6.4 adipocyte free fatty acid secretion trait (VT:0010465) absolute change in adipocyte free fatty acid secretion per unit volume (CMO:0001446) 4 1 34142783 Rat 10755501 Bp390 Blood pressure QTL 390 2.5 arterial blood pressure trait (VT:2000000) diastolic blood pressure (CMO:0000005) 4 27730518 170099664 Rat 1357343 Gluco4 Glucose level QTL 4 0.00002 adipocyte glucose uptake trait (VT:0004185) adipocyte maximal glucose uptake to basal glucose uptake ratio (CMO:0000874) 4 1 34142783 Rat 8552782 Vie1 Viral induced encephalitis QTL 1 26.4 brain integrity trait (VT:0010579) encephalitis incidence/prevalence measurement (CMO:0002361) 4 1 35396961 Rat 6478766 Anxrr47 Anxiety related response QTL 47 0.09637 locomotor behavior trait (VT:0001392) number of entries into a discrete space in an experimental apparatus (CMO:0000960) 4 11038706 56038706 Rat 70222 Eae2 Experimental allergic encephalomyelitis QTL 2 4.3 nervous system integrity trait (VT:0010566) experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046) 4 22288453 40471598 Rat 61330 Eau1 Experimental allergic uveoretinitis QTL 1 0.0003 uvea integrity trait (VT:0010551) experimental autoimmune uveitis score (CMO:0001504) 4 26234499 134199155 Rat 631642 Stl2 Serum triglyceride level QTL 2 3.3 blood triglyceride amount (VT:0002644) serum triglyceride level (CMO:0000360) 4 5894575 57613242 Rat 6478769 Anxrr48 Anxiety related response QTL 48 0.02514 locomotor behavior trait (VT:0001392) amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958) 4 11038706 56038706 Rat 631261 Tcas3 Tongue tumor susceptibility QTL 3 6.88 tongue integrity trait (VT:0010553) number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950) 4 11706604 92690519 Rat 2313401 Anxrr27 Anxiety related response QTL 27 aggression-related behavior trait (VT:0015014) tameness/aggressiveness composite score (CMO:0002136) 4 18900697 63900697 Rat 631209 Bw2 Body weight QTL2 4.2 retroperitoneal fat pad mass (VT:0010430) retroperitoneal fat pad weight to body weight ratio (CMO:0000635) 4 1 45429897 Rat 8552803 Bw144 Body weight QTL 144 16 body mass (VT:0001259) change in body weight to body weight ratio (CMO:0002216) 4 1 35396961 Rat 6909128 Pancm4 Pancreatic morphology QTL 4 11.35 pancreas mass (VT:0010144) pancreas wet weight (CMO:0000626) 4 27862204 126119996 Rat 8694374 Bw155 Body weight QTL 155 3.39 0.001 body lean mass (VT:0010483) lean tissue morphological measurement (CMO:0002184) 4 11038706 56038706 Rat 8552801 Bw143 Body weight QTL 143 7.3 body mass (VT:0001259) change in body weight to body weight ratio (CMO:0002216) 4 1 35396961 Rat 2303168 Bp330 Blood pressure QTL 330 4.25 0.017 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) 4 5889999 148002343 Rat 61412 Pia2 Pristane induced arthritis QTL 2 3.9 joint integrity trait (VT:0010548) post-insult time to onset of experimental arthritis (CMO:0001450) 4 22288453 63245191 Rat 8552807 Vie4 Viral induced encephalitis QTL 4 7.3 brain integrity trait (VT:0010579) encephalitis incidence/prevalence measurement (CMO:0002361) 4 18900697 63900697 Rat 6478724 Anxrr35 Anxiety related response QTL 35 0.00449 defecation behavior trait (VT:0010462) defecation measurement (CMO:0000997) 4 11038706 56038706 Rat 8655906 Rf60 Renal function QTL 60 3.8 blood creatinine amount (VT:0005328) creatinine clearance (CMO:0000765) 4 30448961 82336920 Rat 61415 Eae11 Experimental allergic encephalomyelitis QTL 11 2.9 nervous system integrity trait (VT:0010566) post-insult time to onset of experimental autoimmune encephalomyelitis (CMO:0001422) 4 1 40471598 Rat 619616 Bp79 Blood pressure QTL 79 0.0292 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) 4 5889999 50889999 Rat 8552809 Vie5 Viral induced encephalitis QTL 5 25.3 brain integrity trait (VT:0010579) encephalitis incidence/prevalence measurement (CMO:0002361) 4 1 35396961 Rat 7387227 Uae40 Urinary albumin excretion QTL 40 2.9 0.0052 urine albumin amount (VT:0002871) urine albumin excretion rate (CMO:0000757) 4 18913151 63913151 Rat 6909122 Insul22 Insulin level QTL 22 4.63 blood insulin amount (VT:0001560) plasma insulin level (CMO:0000342) 4 27862204 62997402 Rat 738021 Hcar13 Hepatocarcinoma resistance QTL 13 4.3 liver integrity trait (VT:0010547) liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464) 4 1 33538816 Rat 1358203 Stl19 Serum triglyceride level QTL 19 2.8 0.002 blood triglyceride amount (VT:0002644) serum triglyceride level (CMO:0000360) 4 21925151 66925151 Rat 70192 BpQTLcluster5 Blood pressure QTL cluster 5 4.183 arterial blood pressure trait (VT:2000000) absolute change in mean arterial blood pressure (CMO:0000533) 4 1 63900697 Rat 9590304 Scort17 Serum corticosterone level QTL 17 4.96 0.001 blood corticosterone amount (VT:0005345) plasma corticosterone level (CMO:0001173) 4 11038706 56038706 Rat 2316958 Gluco58 Glucose level QTL 58 10 blood glucose amount (VT:0000188) blood glucose level (CMO:0000046) 4 12212457 182430611 Rat 1354665 Stl10 Serum triglyceride level QTL 10 3.57 blood triglyceride amount (VT:0002644) serum triglyceride level (CMO:0000360) 4 22288453 45429897 Rat 1300141 Bp178 Blood pressure QTL 178 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) 4 10758701 40490708 Rat