Suz12 (SUZ12 polycomb repressive complex 2 subunit) - Rat Genome Database

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Gene: Suz12 (SUZ12 polycomb repressive complex 2 subunit) Rattus norvegicus
Analyze
Symbol: Suz12
Name: SUZ12 polycomb repressive complex 2 subunit
RGD ID: 1593621
Description: Predicted to enable several functions, including DNA binding activity; histone H3K9me2/3 reader activity; and lncRNA binding activity. Involved in several processes, including negative regulation of chemokine production; negative regulation of epithelial cell proliferation; and response to retinoic acid. Predicted to be located in sex chromatin. Predicted to be part of nucleus; protein-DNA complex; and ribonucleoprotein complex. Predicted to be active in nucleus. Biomarker of spina bifida. Human ortholog(s) of this gene implicated in renal Wilms' tumor. Orthologous to human SUZ12 (SUZ12 polycomb repressive complex 2 subunit); PARTICIPATES IN histone modification pathway; INTERACTS WITH bisphenol A; morphine; (-)-demecolcine (ortholog).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC688041; polycomb protein SUZ12; similar to Polycomb protein Suz12 (Suppressor of zeste 12 protein homolog)
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81065,464,948 - 65,510,846 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1065,464,969 - 65,510,846 (+)EnsemblGRCr8
mRatBN7.21064,967,035 - 65,012,916 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1064,966,967 - 65,012,738 (+)EnsemblmRatBN7.2
Rnor_6.01067,325,101 - 67,371,588 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1067,325,347 - 67,369,668 (+)Ensemblrn6Rnor6.0
Rnor_5.01066,983,892 - 67,031,108 (+)NCBIRnor_5.0Rnor_5.0rn5
Celera1063,933,379 - 63,979,240 (+)NCBICelera
Cytogenetic Map10q25NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. SET for life: biochemical activities and biological functions of SET domain-containing proteins. Herz HM, etal., Trends Biochem Sci. 2013 Dec;38(12):621-39. doi: 10.1016/j.tibs.2013.09.004. Epub 2013 Oct 20.
3. Accumulation of malignant renal stem cells is associated with epigenetic changes in normal renal progenitor genes. Metsuyanim S, etal., Stem Cells. 2008 Jul;26(7):1808-17. doi: 10.1634/stemcells.2007-0322. Epub 2008 May 8.
4. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
6. Comprehensive gene review and curation RGD comprehensive gene curation
7. Polycomblike protein PHF1b: a transcriptional sensor for GABA receptor activity. Saha S, etal., BMC Pharmacol Toxicol. 2013 Jul 23;14:37. doi: 10.1186/2050-6511-14-37.
8. Occupying chromatin: Polycomb mechanisms for getting to genomic targets, stopping transcriptional traffic, and staying put. Simon JA and Kingston RE, Mol Cell. 2013 Mar 7;49(5):808-24. doi: 10.1016/j.molcel.2013.02.013.
9. The histone H3K27 methylation mark regulates intestinal epithelial cell density-dependent proliferation and the inflammatory response. Turgeon N, etal., J Cell Biochem. 2013 May;114(5):1203-15. doi: 10.1002/jcb.24463.
10. Polycomb group proteins are essential for spinal cord development. Wang C, etal., Front Biosci (Landmark Ed). 2010 Jun 1;15:1018-22.
Additional References at PubMed
PMID:15385962   PMID:15525528   PMID:16359901   PMID:16687444   PMID:18483221   PMID:19796622   PMID:19847889   PMID:20064375   PMID:20064376   PMID:20075857   PMID:20144788   PMID:20956546  
PMID:21029866   PMID:21630459   PMID:22438827   PMID:22770845   PMID:22911650   PMID:23104054   PMID:23160351   PMID:23273982   PMID:23352431   PMID:24268575   PMID:25547114   PMID:26423156  
PMID:26658965   PMID:28041882   PMID:28229514   PMID:31451685  


Genomics

Comparative Map Data
Suz12
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81065,464,948 - 65,510,846 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1065,464,969 - 65,510,846 (+)EnsemblGRCr8
mRatBN7.21064,967,035 - 65,012,916 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1064,966,967 - 65,012,738 (+)EnsemblmRatBN7.2
Rnor_6.01067,325,101 - 67,371,588 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1067,325,347 - 67,369,668 (+)Ensemblrn6Rnor6.0
Rnor_5.01066,983,892 - 67,031,108 (+)NCBIRnor_5.0Rnor_5.0rn5
Celera1063,933,379 - 63,979,240 (+)NCBICelera
Cytogenetic Map10q25NCBI
SUZ12
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381731,937,007 - 32,001,038 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1731,936,995 - 32,001,045 (+)Ensemblhg38GRCh38
GRCh371730,264,026 - 30,328,057 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361727,288,185 - 27,352,162 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341727,288,184 - 27,352,162NCBI
Celera1727,183,671 - 27,247,908 (+)NCBICelera
Cytogenetic Map17q11.2NCBI
HuRef1726,474,180 - 26,538,191 (+)NCBIHuRef
CHM1_11730,326,518 - 30,390,534 (+)NCBICHM1_1
T2T-CHM13v2.01732,882,881 - 32,946,915 (+)NCBIT2T-CHM13v2.0
Suz12
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391179,883,932 - 79,924,949 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1179,883,932 - 79,924,949 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381179,993,106 - 80,034,123 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1179,993,106 - 80,034,123 (+)Ensemblmm10GRCm38
MGSCv371179,806,608 - 79,847,625 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361179,809,301 - 79,850,318 (+)NCBIMGSCv36mm8
Celera1189,626,764 - 89,670,208 (+)NCBICelera
Cytogenetic Map11B5NCBI
cM Map1147.36NCBI
Suz12
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554816,867,175 - 6,917,548 (+)Ensembl
ChiLan1.0NW_0049554816,867,175 - 6,917,548 (+)NCBIChiLan1.0ChiLan1.0
LOC103785028
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21932,420,755 - 32,536,735 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11734,351,660 - 34,415,575 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01724,790,921 - 24,853,790 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11725,559,017 - 25,586,616 (-)NCBIPanPan1.1PanPan1.1panPan2
SUZ12
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1940,992,797 - 41,038,729 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl940,994,825 - 41,038,645 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha940,152,869 - 40,198,325 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0941,811,525 - 41,857,240 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl941,811,933 - 41,857,217 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1940,596,240 - 40,641,695 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0940,890,422 - 40,935,894 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0940,966,346 - 41,011,837 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Suz12
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560240,044,040 - 40,093,576 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365382,921,719 - 2,971,552 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365382,921,987 - 2,971,521 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SUZ12
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1242,983,601 - 43,032,654 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11242,983,597 - 43,032,671 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21244,772,363 - 44,821,466 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SUZ12
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11625,413,928 - 25,474,311 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1625,413,954 - 25,476,479 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_0236660754,597,733 - 4,660,749 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Suz12
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248754,425,418 - 4,477,909 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248754,425,486 - 4,477,338 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Suz12
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1990,397,288 - 90,443,204 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Suz12
112 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:184
Count of miRNA genes:119
Interacting mature miRNAs:133
Transcripts:ENSRNOT00000073483, ENSRNOT00000074317
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1549846Scl47Serum cholesterol level QTL 473.6blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)105107189796071897Rat
152025229Scl83Serum cholesterol level QTL 834.33blood cholesterol amount (VT:0000180)103621155669161158Rat
1578779Tcas10Tongue tumor susceptibility QTL 103.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)103179628176796281Rat
152025227Bw195Body weight QTL 1955.73body mass (VT:0001259)104748901769161158Rat
1298069Bp168Blood pressure QTL 1685.5blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)102702353598502431Rat
2293669Bmd33Bone mineral density QTL 334.50.0001femur strength trait (VT:0010010)femoral neck polar moment of inertia (CMO:0001670)102744378772443787Rat
152025224Bw193Body weight QTL 1936.47body mass (VT:0001259)105216243375582749Rat
631552Vetf2Vascular elastic tissue fragility QTL 24.50.0002aorta elastic tissue integrity trait (VT:0010556)artery internal elastic lamina non-tumorous lesion count (CMO:0001913)103550938391417879Rat
61449Ciaa2CIA Autoantibody QTL 27.1blood autoantibody amount (VT:0003725)calculated serum anti-type 2 collagen antibody titer (CMO:0001279)1063719161107713808Rat
631557Bp136Blood pressure QTL 1360.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)105686844076129113Rat
61325Aia5Adjuvant induced arthritis QTL 50.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
2293679Bmd30Bone mineral density QTL 303.50.0001femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)102744378772443787Rat
1298078Stresp5Stress response QTL 52.990.00025blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1042546145107713808Rat
1549831Bss6Bone structure and strength QTL 64lumbar vertebra strength trait (VT:0010574)vertebra ultimate force (CMO:0001678)1058073360103073360Rat
70164Bw21Body weight QTL 214.360.00005body mass (VT:0001259)body weight (CMO:0000012)105429633699451733Rat
61463Bp12Blood pressure QTL 126.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)104183127886831278Rat
1579919Bp281Blood pressure QTL 2810.01arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)105046480295464802Rat
2298548Neuinf7Neuroinflammation QTL 73.4nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)1064939013107713808Rat
8694173Bw149Body weight QTL 1494.380.001body mass (VT:0001259)body weight gain (CMO:0000420)104493935989939359Rat
2300218Hpcl2Hepatic cholesterol level QTL 2liver cholesterol amount (VT:0010498)liver cholesterol level (CMO:0001597)104552916496099749Rat
70171Cari1Carrageenan-induced inflammation QTL 14.90.0005hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)1054296227107713808Rat
10450493Bp382Blood pressure QTL 3820.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)105086028895860288Rat
724527Bp148Blood pressure QTL 1480.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)102895035373950353Rat
2300171Bmd58Bone mineral density QTL 584.90.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)102744378772443787Rat
61354Pia10Pristane induced arthritis QTL 100.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
2301967Cm73Cardiac mass QTL 734.55heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)101499153586964295Rat
2313103Bss80Bone structure and strength QTL 8020.0001tibia strength trait (VT:1000284)tibia midshaft endosteal cross-sectional area (CMO:0001716)1062556066107556066Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)14282327487823274Rat
2313105Bss79Bone structure and strength QTL 791.80.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)1062556066107556066Rat
9589030Epfw9Epididymal fat weight QTL 919.240.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)104493935989939359Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014991535107556066Rat
2293652Bmd22Bone mineral density QTL 224.90.0001femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)102744378772443787Rat
70198BpQTLcluster9Blood pressure QTL cluster 92.94arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)104282327487823274Rat
2306970Anxrr22Anxiety related response QTL 225.95fear/anxiety-related behavior trait (VT:1000241)number of periods of voluntary immobility (CMO:0001045)106184349698710773Rat
2306787Ean3Experimental allergic neuritis QTL 33.1nervous system integrity trait (VT:0010566)body weight loss (CMO:0001399)105429622767476781Rat
7387312Bw125Body weight QTL 12530.0047retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight (CMO:0000356)1065390777107713808Rat
724556Pur2Proteinuria QTL 25.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)102293137391127454Rat
8662860Vetf10Vascular elastic tissue fragility QTL 10artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)10666092373950353Rat
2306792Ean4Experimental allergic neuritis QTL 44nervous system integrity trait (VT:0010566)IFNG-secreting splenocyte count (CMO:0002122)104949549294495492Rat
61387Bp1Blood pressure QTL 15.1arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1052269185107713808Rat
1354587Kidm21Kidney mass QTL 213.3kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)101553301273695498Rat
634329Pia15Pristane induced arthritis QTL 153.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)102466212373695339Rat
2298481Eau9Experimental allergic uveoretinitis QTL 90.0169uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)106413959783061459Rat
2298480Eau7Experimental allergic uveoretinitis QTL 70.0049uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)103550938380509383Rat
1358915Stresp7Stress response QTL 73.52blood norepinephrine amount (VT:0005663)plasma norepinephrine level (CMO:0001010)1065307813107713808Rat
70363Bp71Blood pressure QTL 710.04arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1061843496106843496Rat
61402Niddm3Non-insulin dependent diabetes mellitus QTL 34.58blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)106184363383061236Rat
1331791Cm31Cardiac mass QTL 313.84606heart mass (VT:0007028)heart wet weight (CMO:0000069)102980091091417879Rat
631530Tls3T-lymphoma susceptibility QTL 300.0001thymus integrity trait (VT:0010555)percentage of study population developing T-cell lymphomas during a period of time (CMO:0001911)102758722696099902Rat
2289985Bp305Blood pressure QTL 305arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)102907697874076978Rat
1354608Cm33Cardiac mass QTL 332.8heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)105530797293608131Rat
1558643Cm44Cardiac mass QTL 444.80.0000368heart mass (VT:0007028)heart wet weight (CMO:0000069)1061843496100198886Rat
8552805Bw145Body weight QTL 1452.2body mass (VT:0001259)change in body weight to body weight ratio (CMO:0002216)104360879388608793Rat
631267Cia20Collagen induced arthritis QTL 203.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
2293705Bmd25Bone mineral density QTL 257.10.0001femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)102744378772443787Rat
1331839Eae18bExperimental allergic encephalomyelitis QTL 18b5.80.03nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)106174653268282731Rat
631269Cia22Collagen induced arthritis QTL 228.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040535708107713808Rat
1576308Schws1Schwannoma susceptibility QTL 10.0041nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)1040535708107713808Rat
631268Cia21Collagen induced arthritis QTL 213.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1014991535107713808Rat
7207811Bmd90Bone mineral density QTL 905.2femur size trait (VT:1000369)femoral neck cross-sectional area (CMO:0001697)104994371094943710Rat
1576311Pia26Pristane induced arthritis QTL 26joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)103112911376129113Rat
631270Cia23Collagen induced arthritis QTL 233.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040535708107713808Rat
7411614Foco18Food consumption QTL 180.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)104493935989939359Rat
631526Bp76Blood pressure QTL 760.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)106184363367241334Rat
6893336Cm75Cardiac mass QTL 750.10.87heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)1061843496100198886Rat
631547Bp87Blood pressure QTL 874.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)104786912992869129Rat
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10686461896620484Rat
12880050Am10Aortic mass QTL 100.016aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)103950348784503487Rat
2292436Bp310Blood pressure QTL 310arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)105060467795604677Rat
6893342Cm78Cardiac mass QTL 780.10.88heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)103550938388177745Rat
634354Rends3Renal damage susceptibility QTL 30.05kidney blood vessel morphology trait (VT:0000530)organ lesion measurement (CMO:0000677)1061997479106997479Rat
631542Bp82Blood pressure QTL 826.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)102702353599451848Rat

Markers in Region
RH133936  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21064,972,923 - 64,973,128 (+)MAPPERmRatBN7.2
Rnor_6.01067,331,012 - 67,331,217NCBIRnor6.0
Rnor_5.01066,990,000 - 66,990,205UniSTSRnor5.0
Celera1063,939,266 - 63,939,471UniSTS
RH142937  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21064,975,487 - 64,975,624 (+)MAPPERmRatBN7.2
Rnor_6.01067,333,569 - 67,333,705NCBIRnor6.0
Rnor_5.01066,992,710 - 66,992,846UniSTSRnor5.0
Celera1063,941,830 - 63,941,966UniSTS
BF395880  
Rat AssemblyChrPosition (strand)SourceJBrowse
Celera1063,968,821 - 63,968,987UniSTS
BF398270  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21065,010,485 - 65,010,680 (+)MAPPERmRatBN7.2
Rnor_6.01067,369,158 - 67,369,352NCBIRnor6.0
Rnor_5.01067,028,678 - 67,028,872UniSTSRnor5.0
Celera1063,976,810 - 63,977,004UniSTS
UniSTS:236667  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21065,012,446 - 65,012,650 (+)MAPPERmRatBN7.2
Rnor_6.01067,371,119 - 67,371,322NCBIRnor6.0
Rnor_5.01067,030,639 - 67,030,842UniSTSRnor5.0
Celera1063,978,771 - 63,978,974UniSTS
RH135952  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81065,506,117 - 65,506,762 (+)Marker Load Pipeline
mRatBN7.21065,008,208 - 65,008,853 (+)MAPPERmRatBN7.2
Rnor_6.01067,366,881 - 67,367,525NCBIRnor6.0
Rnor_5.01067,026,401 - 67,027,045UniSTSRnor5.0
Celera1063,974,533 - 63,975,177UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000079002   ⟹   ENSRNOP00000072250
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1064,966,967 - 65,012,738 (+)Ensembl
Rnor_6.0 Ensembl1067,325,347 - 67,369,668 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000085914   ⟹   ENSRNOP00000069305
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1065,464,969 - 65,510,846 (+)Ensembl
mRatBN7.2 Ensembl1064,966,967 - 65,012,738 (+)Ensembl
Rnor_6.0 Ensembl1067,325,347 - 67,369,668 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000097306   ⟹   ENSRNOP00000093177
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1065,464,969 - 65,510,846 (+)Ensembl
mRatBN7.2 Ensembl1064,966,967 - 65,012,738 (+)Ensembl
RefSeq Acc Id: NM_001427659   ⟹   NP_001414588
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81065,464,969 - 65,510,846 (+)NCBI
RefSeq Acc Id: XM_039087645   ⟹   XP_038943573
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81065,464,948 - 65,510,795 (+)NCBI
mRatBN7.21064,967,035 - 65,012,916 (+)NCBI
RefSeq Acc Id: XM_039087646   ⟹   XP_038943574
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81065,491,670 - 65,510,795 (+)NCBI
mRatBN7.21064,993,145 - 65,012,916 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001414588 (Get FASTA)   NCBI Sequence Viewer  
  XP_038943573 (Get FASTA)   NCBI Sequence Viewer  
  XP_038943574 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000069305
  ENSRNOP00000069305.2
  ENSRNOP00000093177
  ENSRNOP00000093177.1
Ensembl Acc Id: ENSRNOP00000072250   ⟸   ENSRNOT00000079002
Ensembl Acc Id: ENSRNOP00000069305   ⟸   ENSRNOT00000085914
RefSeq Acc Id: XP_038943573   ⟸   XM_039087645
- Peptide Label: isoform X1
- UniProtKB: A0A0G2JV08 (UniProtKB/TrEMBL),   A0A0G2K2I0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038943574   ⟸   XM_039087646
- Peptide Label: isoform X2
- UniProtKB: A6HH95 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000093177   ⟸   ENSRNOT00000097306
RefSeq Acc Id: NP_001414588   ⟸   NM_001427659
- UniProtKB: A0A0G2K2I0 (UniProtKB/TrEMBL),   A0A8I6AIG5 (UniProtKB/TrEMBL)
Protein Domains
Polycomb protein SUZ12-like zinc finger   Polycomb protein VEFS-Box

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0A0G2K2I0-F1-model_v2 AlphaFold A0A0G2K2I0 1-740 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1593621 AgrOrtholog
BioCyc Gene G2FUF-23990 BioCyc
Ensembl Genes ENSRNOG00000058663 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000085914 ENTREZGENE
  ENSRNOT00000085914.3 UniProtKB/TrEMBL
  ENSRNOT00000097306 ENTREZGENE
  ENSRNOT00000097306.2 UniProtKB/TrEMBL
InterPro Polycomb_protein_VEFS-Box UniProtKB/TrEMBL
  Znf_SUZ12 UniProtKB/TrEMBL
NCBI Gene 688041 ENTREZGENE
PANTHER POLYCOMB GROUP PROTEIN UniProtKB/TrEMBL
  POLYCOMB PROTEIN SUZ12 UniProtKB/TrEMBL
Pfam VEFS-Box UniProtKB/TrEMBL
  Zn_SUZ12 UniProtKB/TrEMBL
PhenoGen Suz12 PhenoGen
RatGTEx ENSRNOG00000058663 RatGTEx
UniProt A0A0G2JV08 ENTREZGENE, UniProtKB/TrEMBL
  A0A0G2K2I0 ENTREZGENE
  A0A8I6AIG5 ENTREZGENE, UniProtKB/TrEMBL
  A6HH95 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2014-07-29 Suz12  SUZ12 polycomb repressive complex 2 subunit  LOC688041  similar to Polycomb protein Suz12 (Suppressor of zeste 12 protein homolog)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-11-20 LOC688041  similar to Polycomb protein Suz12 (Suppressor of zeste 12 protein homolog)      Symbol and Name status set to provisional 70820 PROVISIONAL