Pappa2 (pappalysin 2) - Rat Genome Database

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Gene: Pappa2 (pappalysin 2) Rattus norvegicus
Analyze
Symbol: Pappa2
Name: pappalysin 2
RGD ID: 1591785
Description: Predicted to enable metalloendopeptidase activity. Involved in response to salt stress. Located in apical plasma membrane. Orthologous to human PAPPA2 (pappalysin 2); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran; 3,3',4,4',5-pentachlorobiphenyl.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC680069; LOC680415; pappalysin-2; similar to pappalysin 2 isoform 1; similar to Pappalysin-2 precursor (Pregnancy-associated plasma protein-A2) (PAPP-A2) (Pregnancy-associated plasma protein-E1) (PAPP-E)
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: Pappa2em4Mcwi ; Pappa2em5Mcwi
Genetic Models: SS.BN-(D13Hmgc1048-D13Hmgc1050)-Pappa2em4Mcwi ; SS.BN-(D13Hmgc1048-D13Hmgc1050)-Pappa2em5Mcwi
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81373,407,385 - 73,683,699 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1373,407,385 - 73,681,568 (-)EnsemblGRCr8
mRatBN7.21370,873,918 - 71,147,874 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1370,876,794 - 71,147,779 (-)EnsemblmRatBN7.2
Rnor_6.01376,389,150 - 76,660,248 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1376,389,150 - 76,660,245 (-)Ensemblrn6Rnor6.0
Rnor_5.01381,303,663 - 81,574,402 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41374,286,881 - 74,379,736 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1370,687,413 - 70,959,267 (-)NCBICelera
Cytogenetic Map13q22NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. Pappa2 is linked to salt-sensitive hypertension in Dahl S rats. Cowley AW Jr, etal., Physiol Genomics. 2016 Jan;48(1):62-72. doi: 10.1152/physiolgenomics.00097.2015. Epub 2015 Nov 3.
2. Characterization of biological pathways associated with a 1.37 Mbp genomic region protective of hypertension in Dahl S rats. Cowley AW, etal., Physiol Genomics. 2014 Jun 1;46(11):398-410. doi: 10.1152/physiolgenomics.00179.2013. Epub 2014 Apr 8.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. GOA pipeline RGD automated data pipeline
5. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:11264294   PMID:11513734   PMID:23376485   PMID:23457539   PMID:23533145  


Genomics

Comparative Map Data
Pappa2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81373,407,385 - 73,683,699 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1373,407,385 - 73,681,568 (-)EnsemblGRCr8
mRatBN7.21370,873,918 - 71,147,874 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1370,876,794 - 71,147,779 (-)EnsemblmRatBN7.2
Rnor_6.01376,389,150 - 76,660,248 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1376,389,150 - 76,660,245 (-)Ensemblrn6Rnor6.0
Rnor_5.01381,303,663 - 81,574,402 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41374,286,881 - 74,379,736 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1370,687,413 - 70,959,267 (-)NCBICelera
Cytogenetic Map13q22NCBI
PAPPA2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381176,463,175 - 176,845,601 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1176,463,171 - 176,845,601 (+)Ensemblhg38GRCh38
GRCh371176,432,311 - 176,814,737 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361174,698,930 - 175,078,595 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341173,163,963 - 173,391,617NCBI
Celera1149,542,925 - 149,922,011 (+)NCBICelera
Cytogenetic Map1q25.2NCBI
HuRef1147,658,586 - 148,038,306 (+)NCBIHuRef
CHM1_11177,856,925 - 178,236,093 (+)NCBICHM1_1
T2T-CHM13v2.01175,818,447 - 176,200,273 (+)NCBIT2T-CHM13v2.0
Pappa2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391158,539,297 - 158,788,019 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1158,539,297 - 158,808,060 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381158,711,727 - 158,960,451 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1158,711,727 - 158,980,490 (-)Ensemblmm10GRCm38
MGSCv371160,641,862 - 160,887,569 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361160,548,404 - 160,794,115 (-)NCBIMGSCv36mm8
Celera1161,107,178 - 161,348,433 (-)NCBICelera
Cytogenetic Map1H1NCBI
cM Map168.49NCBI
Pappa2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540616,169,759 - 16,430,206 (+)Ensembl
ChiLan1.0NW_00495540616,167,764 - 16,430,165 (+)NCBIChiLan1.0ChiLan1.0
PAPPA2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2172,873,318 - 73,515,794 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1172,543,742 - 73,186,283 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01151,727,598 - 152,369,670 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11155,675,710 - 156,066,753 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1155,769,395 - 156,063,989 (+)EnsemblpanPan2panpan1.1
PAPPA2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1722,769,594 - 23,038,458 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl722,772,715 - 23,036,517 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha722,294,142 - 22,562,649 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0722,516,581 - 22,785,586 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl722,519,707 - 22,982,506 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1722,422,261 - 22,697,383 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0722,522,272 - 22,790,785 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0722,665,408 - 22,932,430 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Pappa2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934493,909,831 - 94,152,180 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648111,756,085 - 11,997,132 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493648111,756,580 - 11,998,919 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PAPPA2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl9118,365,303 - 118,635,964 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.19118,362,663 - 118,635,972 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.29129,893,498 - 130,286,839 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PAPPA2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12552,432,178 - 52,729,671 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366605554,003,379 - 54,316,468 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pappa2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247715,331,793 - 5,596,752 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247715,332,013 - 5,598,678 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Pappa2
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11038,019,393 - 38,272,493 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Pappa2
1674 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:48
Count of miRNA genes:47
Interacting mature miRNAs:47
Transcripts:ENSRNOT00000039210
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1298066Bp159Blood pressure QTL 1590.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134863963493639634Rat
10755495Bp387Blood pressure QTL 3873.78arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133721624190057603Rat
1354655Bp241Blood pressure QTL 2413.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1338975045103588154Rat
8655951Rf63Renal function QTL 6312.2blood urea nitrogen amount (VT:0005265)plasma urea nitrogen level (CMO:0000586)1371610804109350286Rat
70220Bp55Blood pressure QTL 555.75arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)133992469384924693Rat
8655945Rf61Renal function QTL 613.6blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)137161080489333251Rat
71119Thym2Thymus enlargement QTL 23.8thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)134874981487285480Rat
4889861Pur29Proteinuria QTL 2913.80.005urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)133996821183286298Rat
1331783Bp221Blood pressure QTL 2213.72886arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)137161080489333251Rat
8655959Pur32Proteinuria QTL 328.4urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)137298450699745408Rat
1300166Kidm6Kidney mass QTL 63.93kidney mass (VT:0002707)single kidney wet weight to body weight ratio (CMO:0000622)137161080489333251Rat
2293687Bss26Bone structure and strength QTL 264.60.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1367635937109350286Rat
619615Bp80Blood pressure QTL 800.0354arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)13742179187286911Rat
61340Bp25Blood pressure QTL 254.20.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133708798382087983Rat
1581573Uae36Urinary albumin excretion QTL 36urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)13600200888706694Rat
1549897Stresp12Stress response QTL 123.35stress-related behavior trait (VT:0010451)number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)134098358585983585Rat
724564Uae11Urinary albumin excretion QTL 115.7urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)134735425894285672Rat
738027Lnnr6Liver neoplastic nodule remodeling QTL 63.3liver integrity trait (VT:0010547)liver remodeling tumorous lesion number (CMO:0001461)1365613454109350286Rat
7207885Glom27Glomerulus QTL 273.9kidney glomerulus integrity trait (VT:0010546)kidney crescentic glomeruli count to kidney normal glomeruli count ratio (CMO:0002139)1321120177109350286Rat
7387280Uae43Urinary albumin excretion QTL 435.690.4174urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1368983334109350286Rat
738026Lnnr5Liver neoplastic nodule remodeling QTL 53.29liver integrity trait (VT:0010547)liver remodeling tumorous lesion number (CMO:0001461)136242459288113509Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)133379409678794096Rat
2293702Bss34Bone structure and strength QTL 344.610.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1367635937109350286Rat
61349Bp31Blood pressure QTL 315.75arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)133992469384924693Rat
1576318Schws5Schwannoma susceptibility QTL 50.0351nervous system integrity trait (VT:0010566)post-insult time to trigeminal nerve neurilemmoma formation (CMO:0002019)1364497900109350286Rat
2303563Bw89Body weight QTL 896body mass (VT:0001259)body weight (CMO:0000012)133483494779834947Rat
1354621Rf47Renal function QTL 473.7kidney renin amount (VT:0010559)kidney renin level (CMO:0002166)1311081740103588154Rat
1581554Pur11Proteinuria QTL 11urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)13600200888706694Rat
12879477Bp401Blood pressure QTL 401arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)133981472684814726Rat
1331750Bp220Blood pressure QTL 2202.98arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)133996821184968211Rat
12879475Bp400Blood pressure QTL 400arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1364375743109350286Rat
11530006Niddm72Non-insulin dependent diabetes mellitus QTL 720.001blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)133828629883286298Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)131103588154Rat
2293341Glom15Glomerulus QTL 159.1kidney glomerulus integrity trait (VT:0010546)kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)1367635937109350286Rat

Markers in Region
AW533876  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81373,497,913 - 73,498,077 (+)Marker Load Pipeline
mRatBN7.21370,964,453 - 70,964,617 (+)MAPPERmRatBN7.2
Rnor_6.01376,477,614 - 76,477,777NCBIRnor6.0
Rnor_5.01381,392,746 - 81,392,909UniSTSRnor5.0
RGSC_v3.41374,321,388 - 74,321,551UniSTSRGSC3.4
Celera1370,776,062 - 70,776,225UniSTS
RH 3.4 Map13419.3UniSTS
Cytogenetic Map13q22UniSTS
BI289144  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21371,144,895 - 71,145,099 (+)MAPPERmRatBN7.2
Rnor_6.01376,656,820 - 76,657,023NCBIRnor6.0
Rnor_5.01381,571,167 - 81,571,370UniSTSRnor5.0
RGSC_v3.41374,154,562 - 74,154,765UniSTSRGSC3.4
Celera1370,956,371 - 70,956,574UniSTS
RH 3.4 Map13420.9UniSTS
Cytogenetic Map13q22UniSTS
RH141202  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21370,876,821 - 70,877,038 (+)MAPPERmRatBN7.2
Rnor_6.01376,392,055 - 76,392,271NCBIRnor6.0
Rnor_5.01381,306,568 - 81,306,784UniSTSRnor5.0
RGSC_v3.41373,989,189 - 73,989,405UniSTSRGSC3.4
Celera1370,690,317 - 70,690,533UniSTS
Cytogenetic Map13q22UniSTS


Genetic Models
This gene Pappa2 is modified in the following models/strains:
SS.BN-(D13Hmgc1048-D13Hmgc1050)-Pappa2em4Mcwi     SS.BN-(D13Hmgc1048-D13Hmgc1050)-Pappa2em5Mcwi    


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
14 12 58 133 72 71 40 27 40 6 248 118 11 105 68 90 31 8 8

Sequence


Ensembl Acc Id: ENSRNOT00000039210   ⟹   ENSRNOP00000034649
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1376,389,150 - 76,660,245 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000076345
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1371,137,338 - 71,146,700 (-)Ensembl
Rnor_6.0 Ensembl1376,649,565 - 76,658,964 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000089332   ⟹   ENSRNOP00000068985
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1373,407,385 - 73,681,568 (-)Ensembl
mRatBN7.2 Ensembl1370,876,794 - 71,147,779 (-)Ensembl
Rnor_6.0 Ensembl1376,454,162 - 76,660,043 (-)Ensembl
RefSeq Acc Id: NM_001427778   ⟹   NP_001414707
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81373,407,385 - 73,681,568 (-)NCBI
RefSeq Acc Id: XM_063272600   ⟹   XP_063128670
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81373,407,391 - 73,683,699 (-)NCBI
RefSeq Acc Id: XM_063272601   ⟹   XP_063128671
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81373,407,391 - 73,683,699 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001414707 (Get FASTA)   NCBI Sequence Viewer  
  XP_063128670 (Get FASTA)   NCBI Sequence Viewer  
  XP_063128671 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000068985
  ENSRNOP00000068985.2
Ensembl Acc Id: ENSRNOP00000068985   ⟸   ENSRNOT00000089332
Ensembl Acc Id: ENSRNOP00000034649   ⟸   ENSRNOT00000039210
RefSeq Acc Id: NP_001414707   ⟸   NM_001427778
- Peptide Label: precursor
- UniProtKB: A0A0G2JU68 (UniProtKB/TrEMBL),   A6ID41 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063128671   ⟸   XM_063272601
- Peptide Label: isoform X1
- UniProtKB: A0A0G2JU68 (UniProtKB/TrEMBL),   A6ID41 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063128670   ⟸   XM_063272600
- Peptide Label: isoform X1
- UniProtKB: A0A0G2JU68 (UniProtKB/TrEMBL),   A6ID41 (UniProtKB/TrEMBL)
Protein Domains
Sushi

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZQ32-F1-model_v2 AlphaFold D3ZQ32 1-1788 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1591785 AgrOrtholog
BioCyc Gene G2FUF-17776 BioCyc
Ensembl Genes ENSRNOG00000042860 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000089332 ENTREZGENE
  ENSRNOT00000089332.3 UniProtKB/TrEMBL
Gene3D-CATH 2.60.120.200 UniProtKB/TrEMBL
  3.40.390.10 UniProtKB/TrEMBL
  4.10.470.20 UniProtKB/TrEMBL
  Complement Module, domain 1 UniProtKB/TrEMBL
InterPro ConA-like_subgrp UniProtKB/TrEMBL
  FN3_sf UniProtKB/TrEMBL
  LamG-like UniProtKB/TrEMBL
  MetalloPept_cat_dom_sf UniProtKB/TrEMBL
  Myxo_disulph_rpt UniProtKB/TrEMBL
  Notch_dom UniProtKB/TrEMBL
  PAPPA/PAPPA2 UniProtKB/TrEMBL
  Peptidase_M43 UniProtKB/TrEMBL
  Sushi/SCR/CCP_sf UniProtKB/TrEMBL
  Sushi_SCR_CCP UniProtKB/TrEMBL
NCBI Gene 680415 ENTREZGENE
PANTHER PTHR46130 UniProtKB/TrEMBL
  PTHR46130:SF1 UniProtKB/TrEMBL
Pfam Laminin_G_3 UniProtKB/TrEMBL
  Notch UniProtKB/TrEMBL
  Peptidase_M43 UniProtKB/TrEMBL
  Sushi UniProtKB/TrEMBL
PhenoGen Pappa2 PhenoGen
PROSITE SUSHI UniProtKB/TrEMBL
RatGTEx ENSRNOG00000042860 RatGTEx
SMART CCP UniProtKB/TrEMBL
  LamGL UniProtKB/TrEMBL
  SM00004 UniProtKB/TrEMBL
Superfamily-SCOP Complement_control_module UniProtKB/TrEMBL
  ConA_like_lec_gl UniProtKB/TrEMBL
  Metalloproteases ('zincins'), catalytic domain UniProtKB/TrEMBL
  SSF49265 UniProtKB/TrEMBL
UniProt A0A0G2JU68 ENTREZGENE, UniProtKB/TrEMBL
  A6ID41 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-07-29 Pappa2  pappalysin 2  LOC680069  similar to Pappalysin-2 precursor (Pregnancy-associated plasma protein-A2) (PAPP-A2) (Pregnancy-associated plasma protein-E1) (PAPP-E)  Data merged from RGD:1596819 737654 PROVISIONAL
2013-09-12 Pappa2  pappalysin 2  LOC680415  similar to pappalysin 2 isoform 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-11-20 LOC680069  similar to Pappalysin-2 precursor (Pregnancy-associated plasma protein-A2) (PAPP-A2) (Pregnancy-associated plasma protein-E1) (PAPP-E)      Symbol and Name status set to provisional 70820 PROVISIONAL
2006-11-20 LOC680415  similar to pappalysin 2 isoform 1      Symbol and Name status set to provisional 70820 PROVISIONAL