Ulk1 (unc-51 like autophagy activating kinase 1) - Rat Genome Database

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Gene: Ulk1 (unc-51 like autophagy activating kinase 1) Rattus norvegicus
Analyze
Symbol: Ulk1
Name: unc-51 like autophagy activating kinase 1
RGD ID: 1589743
Description: Predicted to enable several functions, including Hsp90 protein binding activity; enzyme binding activity; and identical protein binding activity. Involved in neuron projection regeneration and positive regulation of autophagosome assembly. Located in axon. Used to study mucositis. Biomarker of metabolic dysfunction-associated steatohepatitis. Orthologous to human ULK1 (unc-51 like autophagy activating kinase 1); PARTICIPATES IN autophagy pathway; mitochondrial autophagy pathway; mTOR signaling pathway; INTERACTS WITH 2,2',5,5'-tetrachlorobiphenyl; 2,3,7,8-tetrachlorodibenzodioxine; 2,4,4'-trichlorobiphenyl.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: serine/threonine-protein kinase ULK1; Ulk1_mapped; Unc-51 like kinase 1 (C. elegans); unc-51-like kinase 1; unc-51-like kinase 1 (mapped)
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81251,511,492 - 51,537,746 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1251,511,492 - 51,537,746 (+)EnsemblGRCr8
mRatBN7.21245,851,710 - 45,877,966 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1245,851,710 - 45,877,966 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1247,027,176 - 47,053,431 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01247,632,609 - 47,658,852 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01246,693,137 - 46,719,380 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01251,908,105 - 51,934,704 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1251,908,448 - 51,934,702 (+)Ensemblrn6Rnor6.0
Rnor_5.01253,646,513 - 53,673,055 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41245,996,251 - 46,022,505 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1247,411,122 - 47,437,376 (+)NCBICelera
Cytogenetic Map12q16NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-Tetrandrine  (ISO)
(-)-anisomycin  (ISO)
(1->4)-beta-D-glucan  (ISO)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,4'-trichlorobiphenyl  (EXP,ISO)
2-methylcholine  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3-chloropropane-1,2-diol  (ISO)
3-methyladenine  (EXP,ISO)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-hydroxynon-2-enal  (ISO)
acadesine  (ISO)
aflatoxin B1  (ISO)
AICA ribonucleotide  (ISO)
aldehydo-D-glucose  (EXP,ISO)
all-trans-retinoic acid  (ISO)
alpha,alpha-trehalose  (ISO)
alpha-amanitin  (EXP,ISO)
amphetamine  (EXP)
antimycin A  (ISO)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
artesunate  (ISO)
atrazine  (EXP)
bafilomycin A1  (EXP)
Benoxacor  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
Benzo[ghi]perylene  (ISO)
berberine  (EXP)
biochanin A  (ISO)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP)
bleomycin A2  (ISO)
buspirone  (EXP)
butanal  (ISO)
C60 fullerene  (EXP)
cadmium atom  (EXP,ISO)
caffeine  (ISO)
calcitriol  (ISO)
cannabidiol  (ISO)
Cannabidivarin  (ISO)
capsaicin  (ISO)
carbon disulfide  (EXP,ISO)
carbon nanotube  (ISO)
chloroquine  (ISO)
chlorpyrifos  (ISO)
choline  (ISO)
ciguatoxin CTX1B  (ISO)
cisplatin  (EXP)
clofibrate  (ISO)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
corosolic acid  (ISO)
coumarin  (ISO)
cucurbitacin E  (ISO)
Curcumol  (EXP)
cyanocob(III)alamin  (ISO)
cycloheximide  (ISO)
cyclosporin A  (ISO)
cypermethrin  (ISO)
D-glucose  (EXP,ISO)
DDE  (ISO)
dexamethasone  (ISO)
dexmedetomidine  (EXP)
dextran sulfate  (ISO)
diarsenic trioxide  (ISO)
Dibutyl phosphate  (ISO)
dinitrogen  (ISO)
diosgenin  (ISO)
disulfiram  (ISO)
dorsomorphin  (EXP,ISO)
doxorubicin  (ISO)
econazole  (ISO)
endosulfan  (EXP)
epoxiconazole  (ISO)
ethanol  (EXP,ISO)
flutamide  (ISO)
folic acid  (ISO)
FR900359  (ISO)
fulvestrant  (ISO)
fumonisin B1  (ISO)
Garcinol  (ISO)
gentamycin  (EXP)
glucose  (EXP,ISO)
glycine betaine  (ISO)
GSK-J4  (ISO)
hemin  (ISO)
inulin  (ISO)
Isobavachin  (ISO)
L-methionine  (ISO)
lanthanum trichloride  (EXP)
maslinic acid  (ISO)
metformin  (ISO)
methamphetamine  (EXP)
methylazoxymethanol  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
myxothiazol  (ISO)
N-(1,3-benzodioxol-5-ylmethyl)-2,6-dichlorobenzamide  (EXP)
N-acetyl-L-cysteine  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-ethyl-N-nitrosourea  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
Nonidet P-40  (ISO)
ozone  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP,ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
pioglitazone  (ISO)
pirinixic acid  (ISO)
promethazine  (ISO)
propiconazole  (ISO)
quercetin  (ISO)
resveratrol  (ISO)
rotenone  (EXP,ISO)
sevoflurane  (EXP)
sirolimus  (EXP,ISO)
sodium arsenite  (ISO)
tebuconazole  (ISO)
Temsirolimus  (ISO)
testosterone  (ISO)
tetrachloromethane  (EXP)
thenoyltrifluoroacetone  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
torin 1  (ISO)
trans-piceid  (ISO)
trifluoperazine  (ISO)
triphenyl phosphate  (ISO)
troglitazone  (ISO)
trovafloxacin  (EXP)
tungsten  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
zidovudine  (EXP)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Assessment of the effect of laser irradiations at different wavelengths (660, 810, 980, and 1064 nm) on autophagy in a rat model of mucositis. Bostanciklioglu M, etal., Lasers Med Sci. 2015 May;30(4):1289-95. doi: 10.1007/s10103-015-1727-4. Epub 2015 Mar 3.
2. Upregulation of miR-96-5p by bone marrow mesenchymal stem cells and their exosomes alleviate non-alcoholic steatohepatitis: Emphasis on caspase-2 signaling inhibition. El-Derany MO and AbdelHamid SG, Biochem Pharmacol. 2021 Aug;190:114624. doi: 10.1016/j.bcp.2021.114624. Epub 2021 May 27.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. ULK1 plays a critical role in AMPK-mediated myocardial autophagy and contractile dysfunction following acute alcohol challenge. Kandadi MR, etal., Curr Pharm Des. 2013;19(27):4874-87.
5. Tougu Xiaotong capsule inhibits the tidemark replication and cartilage degradation of papain-induced osteoarthritis by the regulation of chondrocyte autophagy. Li X, etal., Int J Mol Med. 2013 Jun;31(6):1349-56. doi: 10.3892/ijmm.2013.1341. Epub 2013 Apr 9.
6. Identification of new kinase clusters required for neurite outgrowth and retraction by a loss-of-function RNA interference screen. Loh SH, etal., Cell Death Differ. 2008 Feb;15(2):283-98. Epub 2007 Nov 16.
7. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
8. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
9. GOA pipeline RGD automated data pipeline
10. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
11. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
12. Comprehensive gene review and curation RGD comprehensive gene curation
13. Early and sustained activation of autophagy in degenerating axons after spinal cord injury. Ribas VT, etal., Brain Pathol. 2015 Mar;25(2):157-70. doi: 10.1111/bpa.12170. Epub 2014 Sep 12.
14. LC3 conjugation system in mammalian autophagy. Tanida I, etal., Int J Biochem Cell Biol. 2004 Dec;36(12):2503-18.
15. Selective removal of mitochondria via mitophagy: distinct pathways for different mitochondrial stresses. Wei H, etal., Biochim Biophys Acta. 2015 Oct;1853(10 Pt B):2784-90. doi: 10.1016/j.bbamcr.2015.03.013. Epub 2015 Apr 1.
16. Identification of mouse ULK1, a novel protein kinase structurally related to C. elegans UNC-51. Yan J, etal., Biochem Biophys Res Commun 1998 May 8;246(1):222-7.
17. Mammalian autophagy: core molecular machinery and signaling regulation. Yang Z and Klionsky DJ, Curr Opin Cell Biol. 2010 Apr;22(2):124-31. Epub 2009 Dec 23.
Additional References at PubMed
PMID:10624947   PMID:11146101   PMID:15014045   PMID:16940348   PMID:17389358   PMID:17595159   PMID:18443221   PMID:18936157   PMID:19211835   PMID:19258318   PMID:20562859   PMID:21220506  
PMID:21258367   PMID:21855797   PMID:22354037   PMID:22456507   PMID:22539723   PMID:22613832   PMID:22885598   PMID:23524951   PMID:25126726   PMID:25891078   PMID:26018745   PMID:26647915  
PMID:27103069   PMID:28389568   PMID:29196462   PMID:29391491   PMID:29563162   PMID:30230261   PMID:32341448   PMID:32867795   PMID:34296305   PMID:36104669   PMID:36240643   PMID:37191448  
PMID:38056619   PMID:38325289  


Genomics

Comparative Map Data
Ulk1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81251,511,492 - 51,537,746 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1251,511,492 - 51,537,746 (+)EnsemblGRCr8
mRatBN7.21245,851,710 - 45,877,966 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1245,851,710 - 45,877,966 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1247,027,176 - 47,053,431 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01247,632,609 - 47,658,852 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01246,693,137 - 46,719,380 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01251,908,105 - 51,934,704 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1251,908,448 - 51,934,702 (+)Ensemblrn6Rnor6.0
Rnor_5.01253,646,513 - 53,673,055 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41245,996,251 - 46,022,505 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1247,411,122 - 47,437,376 (+)NCBICelera
Cytogenetic Map12q16NCBI
ULK1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3812131,894,622 - 131,923,150 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl12131,894,621 - 131,923,161 (+)Ensemblhg38GRCh38
GRCh3712132,379,167 - 132,407,695 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3612130,945,232 - 130,973,649 (+)NCBIBuild 36Build 36hg18NCBI36
Build 3412131,045,508 - 131,073,926NCBI
Celera12132,008,428 - 132,026,099 (+)NCBICelera
Cytogenetic Map12q24.33NCBI
HuRef12129,276,372 - 129,293,381 (+)NCBIHuRef
CHM1_112132,200,212 - 132,228,619 (+)NCBICHM1_1
T2T-CHM13v2.012131,939,343 - 131,971,098 (+)NCBIT2T-CHM13v2.0
Ulk1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395110,932,355 - 110,957,991 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5110,932,354 - 110,957,963 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm385110,784,489 - 110,810,120 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5110,784,488 - 110,810,097 (-)Ensemblmm10GRCm38
MGSCv375111,213,508 - 111,239,100 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv365111,024,791 - 111,050,383 (-)NCBIMGSCv36mm8
Celera5107,916,517 - 107,942,075 (-)NCBICelera
Cytogenetic Map5FNCBI
cM Map553.7NCBI
Ulk1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955482761,811 - 777,133 (-)Ensembl
ChiLan1.0NW_004955482760,200 - 777,133 (-)NCBIChiLan1.0ChiLan1.0
ULK1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v210139,987,482 - 140,016,926 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan112139,984,001 - 140,013,443 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v012129,549,399 - 129,579,087 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.112133,980,316 - 134,007,687 (+)NCBIPanPan1.1PanPan1.1panPan2
ULK1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.126968,714 - 982,244 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl26970,138 - 982,229 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha261,012,410 - 1,033,785 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0261,030,431 - 1,051,812 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl261,030,432 - 1,051,789 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.126967,560 - 988,930 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0261,064,168 - 1,085,536 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.026987,330 - 1,008,708 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Ulk1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118122,532,232 - 122,560,686 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366602,163,844 - 2,187,080 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049366602,160,394 - 2,188,848 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ULK1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1423,423,698 - 23,448,136 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11423,423,693 - 23,448,130 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21424,875,257 - 24,913,433 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ULK1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.111127,276,172 - 127,304,270 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl11127,276,210 - 127,304,497 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_023666037117,654,277 - 117,669,065 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ulk1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474727,681,033 - 27,695,966 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462474727,680,994 - 27,697,342 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Ulk1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11643,533,436 - 43,560,100 (+)NCBIRrattus_CSIRO_v1

miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:741
Count of miRNA genes:308
Interacting mature miRNAs:405
Transcripts:ENSRNOT00000056790
Prediction methods:Microtar, Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2293699Bss49Bone structure and strength QTL 495.610.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra trabecular cross-sectional area (CMO:0001692)121613502952308831Rat
631560Apr1Acute phase response QTL 16.1orosomucoid 1 amount (VT:0010541)plasma orosomucoid 1 level (CMO:0001467)122480502252308831Rat
70213Niddm27Non-insulin dependent diabetes mellitus QTL 273.72blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)121120049452308831Rat
8552964Pigfal17Plasma insulin-like growth factor 1 level QTL 173.5blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)121120049452308831Rat
1331763Wbc2White blood cell count QTL 23.162leukocyte quantity (VT:0000217)total white blood cell count (CMO:0000365)121120049452308831Rat
7411641Foco19Food consumption QTL 1927.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)121120049452308831Rat
7411547Bw129Body weight QTL 1290.001body mass (VT:0001259)body weight gain (CMO:0000420)61120049452308831Rat
7411643Foco20Food consumption QTL 200.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)122598935552308831Rat
1641928Alcrsp5Alcohol response QTL 5response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)121847304152308831Rat
1300162Bp188Blood pressure QTL 1883.19arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)123776414551558799Rat
8552912Pigfal6Plasma insulin-like growth factor 1 level QTL 65blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)121120049752308831Rat
1549829Scl48Serum cholesterol level QTL 485blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)121526424852308831Rat
2303569Gluco44Glucose level QTL 442blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)121847304152308831Rat
10059594Kidm46Kidney mass QTL 463.790.025kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)121174352852308831Rat
8552918Pigfal7Plasma insulin-like growth factor 1 level QTL 7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)121120049452308831Rat
7411588Foco6Food consumption QTL 60.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)121120049452308831Rat
2300186Bmd59Bone mineral density QTL 597.10.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)121613502952308831Rat
7411597Foco10Food consumption QTL 100.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)121120049452308831Rat
1300175Cm5Cardiac mass QTL 53.78heart mass (VT:0007028)heart left ventricle weight to body weight ratio (CMO:0000530)123370043251558799Rat
1331786Kidm11Kidney mass QTL 113.571kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)121618743852308831Rat
631543Bp83Blood pressure QTL 835.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)124413955852308831Rat

Markers in Region
AU041434  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21245,877,606 - 45,877,734 (+)MAPPERmRatBN7.2
Rnor_6.01251,934,343 - 51,934,470NCBIRnor6.0
Rnor_5.01253,672,694 - 53,672,821UniSTSRnor5.0
RGSC_v3.41246,022,146 - 46,022,273UniSTSRGSC3.4
Celera1247,437,017 - 47,437,144UniSTS
Cytogenetic Map12q16UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 161 91 90 59 92 59 6 356 192 11 140 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000056790   ⟹   ENSRNOP00000053633
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1251,511,492 - 51,537,746 (+)Ensembl
mRatBN7.2 Ensembl1245,851,710 - 45,877,966 (+)Ensembl
Rnor_6.0 Ensembl1251,908,448 - 51,934,702 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000109167   ⟹   ENSRNOP00000083023
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1245,851,710 - 45,877,966 (+)Ensembl
RefSeq Acc Id: NM_001108341   ⟹   NP_001101811
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81251,511,492 - 51,537,746 (+)NCBI
mRatBN7.21245,851,710 - 45,877,966 (+)NCBI
Rnor_6.01251,908,448 - 51,934,702 (+)NCBI
Rnor_5.01253,646,513 - 53,673,055 (+)NCBI
RGSC_v3.41245,996,251 - 46,022,505 (+)RGD
Celera1247,411,122 - 47,437,376 (+)RGD
Sequence:
RefSeq Acc Id: XM_006249565   ⟹   XP_006249627
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81251,511,507 - 51,537,746 (+)NCBI
mRatBN7.21245,851,724 - 45,877,966 (+)NCBI
Rnor_6.01251,908,105 - 51,934,704 (+)NCBI
Rnor_5.01253,646,513 - 53,673,055 (+)NCBI
Sequence:
RefSeq Acc Id: XM_063271549   ⟹   XP_063127619
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81251,518,642 - 51,537,746 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001101811 (Get FASTA)   NCBI Sequence Viewer  
  XP_006249627 (Get FASTA)   NCBI Sequence Viewer  
  XP_063127619 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDM14029 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000053633
  ENSRNOP00000053633.4
RefSeq Acc Id: NP_001101811   ⟸   NM_001108341
- UniProtKB: A6J290 (UniProtKB/TrEMBL),   A0A8I6GA79 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006249627   ⟸   XM_006249565
- Peptide Label: isoform X1
- UniProtKB: D3ZMG0 (UniProtKB/TrEMBL),   A0A8I6GA79 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000053633   ⟸   ENSRNOT00000056790
Ensembl Acc Id: ENSRNOP00000083023   ⟸   ENSRNOT00000109167
RefSeq Acc Id: XP_063127619   ⟸   XM_063271549
- Peptide Label: isoform X2
- UniProtKB: A0A8I6GA79 (UniProtKB/TrEMBL)
Protein Domains
Protein kinase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZMG0-F1-model_v2 AlphaFold D3ZMG0 1-1051 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1589743 AgrOrtholog
BioCyc Gene G2FUF-18826 BioCyc
Ensembl Genes ENSRNOG00000037505 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000056790 ENTREZGENE
  ENSRNOT00000056790.5 UniProtKB/TrEMBL
Gene3D-CATH Phosphorylase Kinase, domain 1 UniProtKB/TrEMBL
  Transferase(Phosphotransferase) domain 1 UniProtKB/TrEMBL
InterPro Atg1-like UniProtKB/TrEMBL
  ATG1-like_MIT2 UniProtKB/TrEMBL
  Kinase-like_dom UniProtKB/TrEMBL
  Prot_kinase_cat_dom UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/TrEMBL
  Ser/Thr_kin_STPK_Ulk-1/2 UniProtKB/TrEMBL
  Ser/Thr_kinase_C UniProtKB/TrEMBL
  Ser/Thr_prot_kinase_AS UniProtKB/TrEMBL
KEGG Report rno:360827 UniProtKB/TrEMBL
NCBI Gene 360827 ENTREZGENE
PANTHER PTHR24348 UniProtKB/TrEMBL
  SERINE/THREONINE-PROTEIN KINASE ULK1 UniProtKB/TrEMBL
Pfam ATG1-like_MIT2 UniProtKB/TrEMBL
  DUF3543 UniProtKB/TrEMBL
  Pkinase UniProtKB/TrEMBL
PhenoGen Ulk1 PhenoGen
PIRSF Ser/Thr_PK_STPK_ULK-1/2 UniProtKB/TrEMBL
PROSITE PROTEIN_KINASE_ATP UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/TrEMBL
RatGTEx ENSRNOG00000037505 RatGTEx
SMART S_TKc UniProtKB/TrEMBL
Superfamily-SCOP Kinase_like UniProtKB/TrEMBL
UniProt A0A8I6GA79 ENTREZGENE
  A6J290 ENTREZGENE, UniProtKB/TrEMBL
  D3ZMG0 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-07-12 Ulk1  unc-51 like autophagy activating kinase 1  Ulk1  Unc-51 like kinase 1 (C. elegans)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-07 Ulk1  Unc-51 like kinase 1 (C. elegans)  Ulk1  unc-51-like kinase 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2007-04-13   unc-51-like kinase 1  Ulk1  unc-51-like kinase 1 (mapped)  Name updated 737654 APPROVED
2007-04-13 Ulk1  unc-51-like kinase 1 (mapped)  Ulk1_mapped  unc-51-like kinase 1 (mapped)  Data merged from RGD:3939 737654 APPROVED
2006-11-19 Ulk1  unc-51-like kinase 1 (mapped)      Symbol and Name status set to provisional 70820 PROVISIONAL
2005-11-17 Ulk1_mapped  unc-51-like kinase 1 (mapped)      Symbol and Name updated 1556543 APPROVED
2002-06-10 Ulk1  Unc-51 like kinase 1      Symbol and Name status set to approved 70586 APPROVED