Spx (spexin hormone) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Behavioral & Substance Use Disorder Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Spx (spexin hormone) Rattus norvegicus
Analyze
Symbol: Spx
Name: spexin hormone
RGD ID: 1587448
Description: Predicted to enable neuropeptide hormone activity; type 2 galanin receptor binding activity; and type 3 galanin receptor binding activity. Involved in several processes, including long-chain fatty acid import into cell; negative regulation of appetite; and negative regulation of renal sodium excretion. Located in cytoplasm. Orthologous to human SPX (spexin hormone); INTERACTS WITH 17beta-estradiol; bisphenol A; testosterone.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: hypothetical protein LOC691138; liver regeneration-related protein LRRGT00060; LOC691138; LRRGT00060; neuropeptide Q; Npq; spexin
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84177,087,053 - 177,093,091 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl4177,087,256 - 177,093,091 (+)EnsemblGRCr8
mRatBN7.24175,356,044 - 175,362,082 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4175,356,247 - 175,362,082 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx4181,650,891 - 181,656,929 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04177,435,164 - 177,441,200 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04176,055,727 - 176,061,763 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.04176,629,597 - 176,635,698 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4176,629,800 - 176,641,008 (+)Ensemblrn6Rnor6.0
Rnor_5.04240,843,758 - 240,849,264 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.44179,975,336 - 179,980,842 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera4163,888,558 - 163,894,628 (+)NCBICelera
Cytogenetic Map4q44NCBI
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Identification of novel peptide hormones in the human proteome by hidden Markov model screening. Mirabeau O, etal., Genome Res. 2007 Mar;17(3):320-7. Epub 2007 Feb 6.
3. Spexin expression in normal rat tissues. Porzionato A, etal., J Histochem Cytochem. 2010 Sep;58(9):825-37. doi: 10.1369/jhc.2010.956300. Epub 2010 Jun 7.
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
5. Peptides derived from the prohormone proNPQ/spexin are potent central modulators of cardiovascular and renal function and nociception. Toll L, etal., FASEB J. 2012 Feb;26(2):947-54. doi: 10.1096/fj.11-192831. Epub 2011 Oct 28.
6. Spexin is a novel human peptide that reduces adipocyte uptake of long chain fatty acids and causes weight loss in rodents with diet-induced obesity. Walewski JL, etal., Obesity (Silver Spring). 2014 Jul;22(7):1643-52. doi: 10.1002/oby.20725. Epub 2014 Mar 8.
Additional References at PubMed
PMID:19193193   PMID:20045034   PMID:23080164   PMID:24517231   PMID:31396649   PMID:33632048   PMID:33928538  


Genomics

Comparative Map Data
Spx
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84177,087,053 - 177,093,091 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl4177,087,256 - 177,093,091 (+)EnsemblGRCr8
mRatBN7.24175,356,044 - 175,362,082 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4175,356,247 - 175,362,082 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx4181,650,891 - 181,656,929 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04177,435,164 - 177,441,200 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04176,055,727 - 176,061,763 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.04176,629,597 - 176,635,698 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4176,629,800 - 176,641,008 (+)Ensemblrn6Rnor6.0
Rnor_5.04240,843,758 - 240,849,264 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.44179,975,336 - 179,980,842 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera4163,888,558 - 163,894,628 (+)NCBICelera
Cytogenetic Map4q44NCBI
SPX
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381221,526,296 - 21,532,947 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1221,526,296 - 21,541,249 (+)Ensemblhg38GRCh38
GRCh371221,679,230 - 21,685,881 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361221,570,523 - 21,575,477 (+)NCBIBuild 36Build 36hg18NCBI36
Celera1226,834,644 - 26,839,598 (+)NCBICelera
Cytogenetic Map12p12.1NCBI
HuRef1221,453,255 - 21,458,209 (+)NCBIHuRef
CHM1_11221,644,862 - 21,649,814 (+)NCBICHM1_1
T2T-CHM13v2.01221,405,263 - 21,411,916 (+)NCBIT2T-CHM13v2.0
Spx
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm396142,359,114 - 142,365,466 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl6142,359,167 - 142,365,456 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm386142,413,388 - 142,419,740 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl6142,413,441 - 142,419,730 (+)Ensemblmm10GRCm38
MGSCv376142,361,961 - 142,367,091 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv366142,371,234 - 142,376,962 (+)NCBIMGSCv36mm8
Celera6145,473,941 - 145,479,073 (+)NCBICelera
Cytogenetic Map6G2NCBI
cM Map674.03NCBI
Spx
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541317,173,215 - 17,178,388 (+)Ensembl
ChiLan1.0NW_00495541317,173,215 - 17,178,388 (+)NCBIChiLan1.0ChiLan1.0
SPX
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21075,270,239 - 75,275,011 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11275,266,637 - 75,271,410 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01264,766,136 - 64,771,728 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11267,369,413 - 67,375,680 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1267,369,413 - 67,375,630 (-)EnsemblpanPan2panpan1.1
SPX
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12725,561,636 - 25,572,310 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2725,563,606 - 25,571,093 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2720,780,749 - 20,789,452 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02725,791,296 - 25,799,202 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2725,792,502 - 25,818,889 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12725,584,197 - 25,592,099 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02725,604,663 - 25,615,317 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02720,957,128 - 20,965,827 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
SPX
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl551,920,400 - 51,941,598 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1551,919,474 - 51,929,204 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2555,196,569 - 55,205,161 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SPX
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11121,391,660 - 21,401,860 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1121,392,621 - 21,396,923 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366606913,746,535 - 13,757,244 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Spx
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475217,147,925 - 17,152,430 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462475217,146,644 - 17,154,855 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Spx
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v16163,370 - 169,370 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Spx
30 total Variants

QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
6478754Anxrr43Anxiety related response QTL 430.14035locomotor behavior trait (VT:0001392)distance moved per unit of time into, out of or within a discrete space in an experimental apparatus (CMO:0001493)4146370897184426481Rat
724558Plsm2Polydactyly-luxate syndrome (PLS) morphotypes QTL 20.0003hindlimb integrity trait (VT:0010563)hind foot phalanges count (CMO:0001949)4134095016179095016Rat
6478693Anxrr32Anxiety related response QTL 320.00092locomotor behavior trait (VT:0001392)measurement of voluntary locomotion into, out of or within a discrete space in an experimental apparatus (CMO:0000957)4146370897184426481Rat
6478757Anxrr44Anxiety related response QTL 440.01087locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4155834926184426481Rat
1331738Bp209Blood pressure QTL 2092.979arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)4140059299181024663Rat
6478700Anxrr33Anxiety related response QTL 330.00896locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4146370897184426481Rat
1298524Oia8Oil induced arthritis QTL 8joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4140059299184426481Rat
10053718Scort25Serum corticosterone level QTL 252.150.0097blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)4157292416184426481Rat
738009Sach4Saccharine consumption QTL 44.90.000016consumption behavior trait (VT:0002069)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)460916264184426481Rat
10401796Kidm48Kidney mass QTL 48kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)4147299608184426481Rat
6478718Anxrr34Anxiety related response QTL 340.00896locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4146370897184426481Rat
6478782Anxrr52Anxiety related response QTL 520.02091locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4155834926184426481Rat
1300109Rf13Renal function QTL 133.91renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)4176806581181925369Rat
6478720Alc23Alcohol consumption QTL 230.00509drinking behavior trait (VT:0001422)ethanol drink intake rate to body weight ratio (CMO:0001616)4155834926184426481Rat
6478785Anxrr53Anxiety related response QTL 530.01397locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4155834926184426481Rat
1576316Ept5Estrogen-induced pituitary tumorigenesis QTL 53.8pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)4100752691179366077Rat
1581566Eae21Experimental allergic encephalomyelitis QTL 216.2body mass (VT:0001259)maximum body weight loss to initial body weight ratio (CMO:0001400)4137447185182447185Rat
1578674Bmd12Bone mineral density QTL 123.8femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)4137430611182430611Rat
6478728Anxrr36Anxiety related response QTL 360.01061locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4155834926184426481Rat
738016Alc16Alcohol consumption QTL 163.60.00015consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)460916264184426481Rat
6478733Anxrr37Anxiety related response QTL 370.00095locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4155834926184426481Rat
61362Oia2Oil induced arthritis QTL 20.001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4140059299184426481Rat
6478737Anxrr38Anxiety related response QTL 380.00159locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4155834926184426481Rat
2293659Bmd35Bone mineral density QTL 354.50.0001femur strength trait (VT:0010010)femoral neck ultimate force (CMO:0001703)4160623982184426481Rat
2316958Gluco58Glucose level QTL 5810blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)412212457182430611Rat
6478748Anxrr42Anxiety related response QTL 420.28008locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4146370897184426481Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
2 12 63 27 26 16 21 16 3 69 42 4 58 9 27 10 2 2

Sequence


Ensembl Acc Id: ENSRNOT00000086529   ⟹   ENSRNOP00000068862
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl4176,629,975 - 176,641,008 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000087378   ⟹   ENSRNOP00000071461
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl4177,087,256 - 177,093,091 (+)Ensembl
mRatBN7.2 Ensembl4175,356,247 - 175,362,082 (+)Ensembl
Rnor_6.0 Ensembl4176,629,800 - 176,634,504 (+)Ensembl
RefSeq Acc Id: NM_001083933   ⟹   NP_001077402
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84177,087,053 - 177,093,091 (+)NCBI
mRatBN7.24175,356,044 - 175,362,082 (+)NCBI
Rnor_6.04176,629,597 - 176,635,698 (+)NCBI
Rnor_5.04240,843,758 - 240,849,264 (+)NCBI
RGSC_v3.44179,975,336 - 179,980,842 (+)RGD
Celera4163,888,558 - 163,894,628 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001077402 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAQ96273 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000071461
  ENSRNOP00000071461.1
GenBank Protein M0R8L2 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001077402   ⟸   NM_001083933
- Peptide Label: precursor
- UniProtKB: Q6TXE0 (UniProtKB/Swiss-Prot),   M0R8L2 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSRNOP00000071461   ⟸   ENSRNOT00000087378
Ensembl Acc Id: ENSRNOP00000068862   ⟸   ENSRNOT00000086529

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-M0R8L2-F1-model_v2 AlphaFold M0R8L2 1-116 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1587448 AgrOrtholog
BioCyc Gene G2FUF-42493 BioCyc
Ensembl Genes ENSRNOG00000053700 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000087378 ENTREZGENE
  ENSRNOT00000087378.2 UniProtKB/Swiss-Prot
InterPro Spexin UniProtKB/Swiss-Prot
KEGG Report rno:691138 UniProtKB/Swiss-Prot
NCBI Gene 691138 ENTREZGENE
PANTHER PTHR28590 UniProtKB/Swiss-Prot
  SPEXIN UniProtKB/Swiss-Prot
Pfam Spexin UniProtKB/Swiss-Prot
PhenoGen Spx PhenoGen
RatGTEx ENSRNOG00000053700 RatGTEx
UniProt M0R8L2 ENTREZGENE
  Q6TXE0 ENTREZGENE
  SPXN_RAT UniProtKB/Swiss-Prot
UniProt Secondary Q6TXE0 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2014-04-23 Spx  spexin hormone  LOC691138  hypothetical protein LOC691138  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2013-05-24 LOC691138  hypothetical protein LOC691138  LOC686427  hypothetical protein LOC686427  Data merged from RGD:1597657 1643240 APPROVED
2006-11-20 LOC686427  hypothetical protein LOC686427      Symbol and Name status set to provisional 70820 PROVISIONAL
2006-11-19 LOC691138  hypothetical protein LOC691138      Symbol and Name status set to provisional 70820 PROVISIONAL