SPX (spexin hormone) - Rat Genome Database

Name: SPX
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

Gene: SPX (spexin hormone) Pan paniscus

Analyze

Symbol:

SPX

Name:

spexin hormone

RGD ID:

12007074

Description:

ENCODES a protein that exhibits type 2 galanin receptor binding (ortholog); type 3 galanin receptor binding (ortholog); INVOLVED IN long-chain fatty acid import into cell (ortholog); negative regulation of appetite (ortholog); negative regulation of heart rate (ortholog); ASSOCIATED WITH dilated cardiomyopathy 1O (ortholog); genetic disease (ortholog); FOUND IN cytoplasm (inferred); dense core granule (inferred); extracellular region (inferred)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

spexin; spexin-like

RGD Orthologs

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	SPX (spexin hormone)	NCBI	Ortholog
Mus musculus (house mouse):	Spx (spexin hormone)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus norvegicus (Norway rat):	Spx (spexin hormone)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Spx (spexin hormone)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	SPX (spexin hormone)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	SPX (spexin hormone)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	SPX (spexin hormone)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Spx (spexin hormone)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline

Latest Assembly:

Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly

Position:

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	10	75,270,239 - 75,275,011 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	12	75,266,637 - 75,271,410 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	12	64,766,136 - 64,771,728 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	12	67,369,413 - 67,375,680 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	12	67,369,413 - 67,375,630 (-)	Ensembl	panpan1.1		panPan2

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

dilated cardiomyopathy 1O (ISO)

genetic disease (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

long-chain fatty acid import into cell (ISO)

negative regulation of appetite (ISO)

negative regulation of heart rate (ISO)

negative regulation of renal sodium excretion (ISO)

positive regulation of gastro-intestinal system smooth muscle contraction (IEA)

positive regulation of systemic arterial blood pressure (ISO)

positive regulation of transcription by RNA polymerase II (ISO)

regulation of sensory perception of pain (ISO)

signal transduction (IEA)

Cellular Component

cytoplasm (IEA)

dense core granule (IEA)

extracellular region (IEA)

extracellular space (IEA)

transport vesicle (IEA)

Molecular Function

neuropeptide hormone activity (IEA)

protein binding (ISO)

type 2 galanin receptor binding (ISO)

type 3 galanin receptor binding (ISO)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

SPX
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	10	75,270,239 - 75,275,011 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	12	75,266,637 - 75,271,410 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	12	64,766,136 - 64,771,728 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	12	67,369,413 - 67,375,680 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	12	67,369,413 - 67,375,630 (-)	Ensembl	panpan1.1		panPan2

SPX
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	12	21,526,296 - 21,532,947 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	12	21,526,296 - 21,541,249 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	12	21,679,230 - 21,685,881 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	12	21,570,523 - 21,575,477 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Celera	12	26,834,644 - 26,839,598 (+)	NCBI		Celera
Cytogenetic Map	12	p12.1	NCBI
HuRef	12	21,453,255 - 21,458,209 (+)	NCBI		HuRef
CHM1_1	12	21,644,862 - 21,649,814 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	12	21,405,263 - 21,411,916 (+)	NCBI		T2T-CHM13v2.0

Spx
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	6	142,359,114 - 142,365,466 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	6	142,359,167 - 142,365,456 (+)	Ensembl		GRCm39 Ensembl
GRCm38	6	142,413,388 - 142,419,740 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	6	142,413,441 - 142,419,730 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	6	142,361,961 - 142,367,091 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	6	142,371,234 - 142,376,962 (+)	NCBI		MGSCv36	mm8
Celera	6	145,473,941 - 145,479,073 (+)	NCBI		Celera
Cytogenetic Map	6	G2	NCBI
cM Map	6	74.03	NCBI

Spx
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	4	177,087,053 - 177,093,091 (+)	NCBI		GRCr8
mRatBN7.2	4	175,356,044 - 175,362,082 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	4	175,356,247 - 175,362,082 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	4	181,650,891 - 181,656,929 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	4	177,435,164 - 177,441,200 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	4	176,055,727 - 176,061,763 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	4	176,629,597 - 176,635,698 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	4	176,629,800 - 176,641,008 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	4	240,843,758 - 240,849,264 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	4	179,975,336 - 179,980,842 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	4	163,888,558 - 163,894,628 (+)	NCBI		Celera
Cytogenetic Map	4	q44	NCBI

Spx
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955413	17,173,215 - 17,178,388 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955413	17,173,215 - 17,178,388 (+)	NCBI	ChiLan1.0	ChiLan1.0

SPX
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	27	25,561,636 - 25,572,310 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	27	25,563,606 - 25,571,093 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	27	20,780,749 - 20,789,452 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	27	25,791,296 - 25,799,202 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	27	25,792,502 - 25,818,889 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	27	25,584,197 - 25,592,099 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	27	25,604,663 - 25,615,317 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	27	20,957,128 - 20,965,827 (+)	NCBI		UU_Cfam_GSD_1.0

SPX
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	5	51,920,400 - 51,941,598 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	5	51,919,474 - 51,929,204 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	5	55,196,569 - 55,205,161 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

SPX
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	11	21,391,660 - 21,401,860 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	11	21,392,621 - 21,396,923 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666069	13,746,535 - 13,757,244 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Spx
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624752	17,147,925 - 17,152,430 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624752	17,146,644 - 17,154,855 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_003828894	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JARIFH020000010	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSPPAT00000035738 ⟹ ENSPPAP00000013070

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
PanPan1.1 Ensembl	12	67,369,413 - 67,375,630 (-)	Ensembl

RefSeq Acc Id:

XM_003828894 ⟹ XP_003828942

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
NHGRI_mPanPan1-v2	10	75,270,239 - 75,275,011 (-)	NCBI
NHGRI_mPanPan1	12	75,266,637 - 75,271,410 (-)	NCBI
Mhudiblu_PPA_v0	12	64,766,136 - 64,771,728 (-)	NCBI
PanPan1.1	12	67,369,413 - 67,375,680 (-)	NCBI

Sequence:

show sequence

ATTCCTCTACTTCCTGCAATGAAGCTCCCTGGAGGAGTCATCAGATTCTCAATCTTGCTTGAAG
GCTGACAAGATGTCCCTGTGGACTCCCAAACTCTACTCCAGATGGGGAGGTGCCCTTAACACCA
AGATTTTAAAAGCTCCAATTTCAGAGCAAGAGTCGAAAACTCACAGATAAAGTTATAGTTATTT
CAGGGTTCTGAAAAGACGCAGAACATGAAGGGACTCAGAAGTCTGGCAGCAACAACCTTGGCTC
TTTTCCTGGTGTTTGTTTTCCTGGGAAACTCCAGCTGCGCTCCGCAGAGACTGTTGGAGAGAAG
GAACTGGACTCCTCAAGCTATGCTCTACCTGAAAGGGGCACAGGGTCGACGCTTCATCTCCGAC
CAGAGCCGGAGAAAGGACCTCTCCGACCGGCCACTGCCGGAAAGACGAAGCCCAAATCCCCGAC
TACTAACTATTCCGGAGGCAGCAACCATCTTACTGGCGTCCCTTCAGAAATCACCAGAAGATGA
AGAAAAAAACTTTGATCAAACCAGATTCCTGGAAGACAGTCTGCTTAACTGGTGAAAATATACT
GGATTATGTTTAATTATAGTTCTATTCTCTTTGAAAACATGAACCATGTGAATAAAACCTTTGG
ACCCTTTTATTCCATTTGTAATCTTAAGAACACACACAGATAGTTTTATTCTTTCAGAAACAAA
ATATATGTAGGATGCTTAGCTGAGAACATCATCTTCTTTCATTGCTTCAGGTCCTGTTTAGATG
ACCAAAAATGTTTTCAGATCACCTTGTGTCTTACTCTTGAGTTTCTTAGAATATTTATAATTAT
AAGGCTGAAGACTAAAGTGTTCTTTCCTTTTAACTATAGCCAGTACCTGTCTTGATCTTAGTTG
TGTGTGTTTTTTTTCATTTTGTTACCCACTTGCATTTTGTTTTCACTCAGCAGAAATTCTCCTT
CTCTGTTTTCCTTTTATCCCATCCCCAAGAAGGTGGGAGGAAGGTGAGAAACATGGCAGGATGG
GAAATAGGAGAGTATGACTCTCTATAGCTCATCCAGGAGTAATCAATTAAGAAGATAAGTTGGA
TGACTGTGGAGAAGCTCTGTGATAGGAACGCTTCAGTGTGGTTGCTGAGAGGAGACAGTCATTG
AGGTAGAAGGTTTGCCAAAGATCCAGAGCTCAGAGCTCCCTTTGTGCTCTTTGGGAATTACCTT
GCATTCAATTTAGAAACATGGATCTAAAAGTTACTGGGAAATAAGCAGATGGAGACACACTCTG
TTGTTTATGTATTGAAAGAAGGGAACAAGCCAGTTTTGTTAGAGGTAACTCATTTTCCATGACC
AAACAGACTCAACAGATTCAAGTACTCTGCTTACTCTAATTGACTAGACTCTAGGTTTTATTTG
ACATCATAGCATTACATAAATCACTCTGATAATGTAAGTGCACAATAATATGCCTGATCTCTTC
CTTTTTAAAAGCCAACTTGAGTTCAGTACCATCTGAATACACACACATGCACATATACCCACAC
ACGCATACACACATACTCCTGTGGCAAACATAATAATGTATTTATTTAGAATTATAATATGACC
ATCATGTTAATTATTTTTTACCTAATCAGAGTTGTTATTGACAAATGTCATAAGTGGAAAGTAT
TAATTCTTATTGTCATCAGTATTTAGCCATTATTTAGTAGCTCAAGAATATCTTTATGTGAATG
TCTCAGTAACTTGGAATTGCAATTTCACTGTGTTAAGTAATCAGAACTCTGCTTATAAGATTTA
TCTGTATCTTGTTTCATAATTTAATAATGAAACTAAATTCAAGTTAATGTAATGTTGATCTCTG
TTGAAAAATAACTTGTGAGCATTAAAATATCTGTATGGCATTATAA

hide sequence

Protein Sequences


Protein RefSeqs	XP_003828942	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSPPAP00000013070.1

RefSeq Acc Id:	XP_003828942 ⟸ XM_003828894
- Sequence:	show sequence MKGLRSLAATTLALFLVFVFLGNSSCAPQRLLERRNWTPQAMLYLKGAQGRRFISDQSRRKDLS DRPLPERRSPNPRLLTIPEAATILLASLQKSPEDEEKNFDQTRFLEDSLLNW hide sequence

RefSeq Acc Id:

ENSPPAP00000013070 ⟸ ENSPPAT00000035738

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSPPAG00000029701	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSPPAT00000035738.1	UniProtKB/TrEMBL
InterPro	Spexin	UniProtKB/TrEMBL
KEGG Report	pps:100973140	UniProtKB/TrEMBL
NCBI Gene	SPX	ENTREZGENE
PANTHER	PTHR28590	UniProtKB/TrEMBL
	SPEXIN	UniProtKB/TrEMBL
Pfam	Spexin	UniProtKB/TrEMBL
UniProt	A0A2R9A851_PANPA	UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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