Xaf1 (XIAP associated factor 1) - Rat Genome Database

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Gene: Xaf1 (XIAP associated factor 1) Rattus norvegicus
Analyze
Symbol: Xaf1
Name: XIAP associated factor 1
RGD ID: 1585988
Description: Predicted to enable molecular sequestering activity. Involved in negative regulation of protein-containing complex assembly. Predicted to be active in mitochondrion. Orthologous to human XAF1 (XIAP associated factor 1); INTERACTS WITH bisphenol A; dioxygen; endosulfan.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC679600; similar to XIAP associated factor-1 isoform 2; XIAP associated factor-1; XIAP-associated factor 1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81057,415,935 - 57,428,348 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1057,415,658 - 57,428,349 (+)EnsemblGRCr8
mRatBN7.21056,917,378 - 56,929,791 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1056,917,121 - 56,929,770 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1061,580,392 - 61,592,787 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01061,068,868 - 61,081,263 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01056,567,956 - 56,580,352 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01058,860,647 - 58,872,782 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1058,860,940 - 58,873,674 (+)Ensemblrn6Rnor6.0
Rnor_5.01058,601,058 - 58,613,180 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41059,185,150 - 59,196,549 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1056,046,222 - 56,058,278 (+)NCBICelera
Cytogenetic Map10q24NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-alpha-phellandrene  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
(S)-nicotine  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxynon-2-enal  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-azacytidine  (ISO)
5-fluorouracil  (ISO)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (ISO)
alpha-phellandrene  (ISO)
aluminium atom  (ISO)
aluminium(0)  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
avobenzone  (ISO)
benzo[a]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bortezomib  (ISO)
butanal  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chenodeoxycholic acid  (ISO)
chlordecone  (ISO)
cisplatin  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
curcumin  (ISO)
cyclophosphamide  (ISO)
cyclosporin A  (ISO)
cypermethrin  (ISO)
D-glucose  (ISO)
deoxycholic acid  (ISO)
diarsenic trioxide  (ISO)
dimethylarsinous acid  (ISO)
dioxygen  (EXP)
diquat  (ISO)
disodium selenite  (ISO)
diuron  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
ethyl methanesulfonate  (ISO)
etoposide  (ISO)
folic acid  (ISO)
formaldehyde  (ISO)
fructose  (ISO)
gentamycin  (EXP)
glucose  (ISO)
glycochenodeoxycholic acid  (ISO)
glycocholic acid  (ISO)
glycodeoxycholic acid  (ISO)
glyphosate  (ISO)
hydrogen peroxide  (ISO)
hydroquinone  (ISO)
lead diacetate  (ISO)
leupeptin  (ISO)
lipopolysaccharide  (ISO)
methotrexate  (ISO)
methyl methanesulfonate  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
nickel atom  (ISO)
nickel dichloride  (ISO)
nickel sulfate  (ISO)
nicotine  (ISO)
ochratoxin A  (ISO)
okadaic acid  (ISO)
paracetamol  (EXP,ISO)
pentachlorophenol  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenobarbital  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (ISO)
sotorasib  (ISO)
succimer  (ISO)
sulforaphane  (ISO)
temozolomide  (ISO)
tetrachloromethane  (EXP)
tetraphene  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
trametinib  (ISO)
triclosan  (ISO)
triphenyl phosphate  (ISO)
triptonide  (ISO)
trovafloxacin  (ISO)
tunicamycin  (ISO)
urethane  (ISO)
vanadyl sulfate  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
mitochondrion  (IBA,ISO)
nucleoplasm  (ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
3. Nuclear translocation of X-linked inhibitor of apoptosis (XIAP) determines cell fate after hypoxia ischemia in neonatal brain. Russell JC, etal., J Neurochem. 2008 Aug;106(3):1357-70. Epub 2008 May 13.
Additional References at PubMed
PMID:15905097   PMID:18035482   PMID:24743731  


Genomics

Comparative Map Data
Xaf1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81057,415,935 - 57,428,348 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1057,415,658 - 57,428,349 (+)EnsemblGRCr8
mRatBN7.21056,917,378 - 56,929,791 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1056,917,121 - 56,929,770 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1061,580,392 - 61,592,787 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01061,068,868 - 61,081,263 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01056,567,956 - 56,580,352 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01058,860,647 - 58,872,782 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1058,860,940 - 58,873,674 (+)Ensemblrn6Rnor6.0
Rnor_5.01058,601,058 - 58,613,180 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41059,185,150 - 59,196,549 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1056,046,222 - 56,058,278 (+)NCBICelera
Cytogenetic Map10q24NCBI
XAF1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38176,755,447 - 6,775,647 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl176,755,377 - 6,775,647 (+)Ensemblhg38GRCh38
GRCh37176,658,766 - 6,678,966 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36176,599,880 - 6,619,690 (+)NCBIBuild 36Build 36hg18NCBI36
Celera176,684,938 - 6,704,750 (+)NCBICelera
Cytogenetic Map17p13.1NCBI
HuRef176,554,687 - 6,574,528 (+)NCBIHuRef
CHM1_1176,669,375 - 6,689,184 (+)NCBICHM1_1
T2T-CHM13v2.0176,656,081 - 6,676,290 (+)NCBIT2T-CHM13v2.0
Xaf1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391172,192,229 - 72,204,560 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1172,192,455 - 72,204,559 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381172,301,461 - 72,313,733 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1172,301,629 - 72,313,733 (+)Ensemblmm10GRCm38
MGSCv371172,115,131 - 72,127,235 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361172,117,860 - 72,124,963 (+)NCBIMGSCv36mm8
Celera1179,823,114 - 79,835,167 (+)NCBICelera
Cytogenetic Map11B4NCBI
cM Map1143.99NCBI
Xaf1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495546712,240,075 - 12,257,595 (+)NCBIChiLan1.0ChiLan1.0
LOC100995017
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21914,347,691 - 14,368,948 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11716,312,961 - 16,334,556 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0176,785,040 - 6,806,177 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1176,774,666 - 6,794,947 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl176,774,951 - 6,794,947 (+)EnsemblpanPan2panpan1.1
XAF1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1530,626,356 - 30,636,731 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl530,626,356 - 30,637,130 (-)NCBIcanFam3CanFam3.1
CanFam3.1 Ensembl530,626,356 - 30,637,130 (-)EnsemblcanFam3CanFam3.1
ROS_Cfam_1.0530,727,755 - 30,738,114 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl530,727,754 - 30,738,042 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1530,694,084 - 30,704,443 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0530,652,636 - 30,662,990 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0530,825,789 - 30,836,143 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Xaf1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560254,644,568 - 54,661,474 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366771,239,476 - 1,256,411 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049366771,239,501 - 1,256,332 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
XAF1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1250,645,094 - 50,659,642 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11250,644,783 - 50,659,807 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21252,643,901 - 52,659,315 (-)NCBISscrofa10.2Sscrofa10.2susScr3
XAF1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1166,117,228 - 6,135,535 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl166,118,094 - 6,134,902 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366605915,304,084 - 15,322,426 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Xaf1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247867,269,986 - 7,286,640 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247867,270,601 - 7,286,431 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Xaf1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1943,208,436 - 43,219,933 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Xaf1
35 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:153
Count of miRNA genes:112
Interacting mature miRNAs:122
Transcripts:ENSRNOT00000056551, ENSRNOT00000074523
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61441Btemp1Thermal response to stress QTL 14body temperature trait (VT:0005535)core body temperature (CMO:0001036)103589345164140567Rat
1549846Scl47Serum cholesterol level QTL 473.6blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)105107189796071897Rat
152025229Scl83Serum cholesterol level QTL 834.33blood cholesterol amount (VT:0000180)103621155669161158Rat
1578779Tcas10Tongue tumor susceptibility QTL 103.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)103179628176796281Rat
152025227Bw195Body weight QTL 1955.73body mass (VT:0001259)104748901769161158Rat
631564Apr3Acute phase response QTL 33.9blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)101577675460776754Rat
1298069Bp168Blood pressure QTL 1685.5blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)102702353598502431Rat
2293669Bmd33Bone mineral density QTL 334.50.0001femur strength trait (VT:0010010)femoral neck polar moment of inertia (CMO:0001670)102744378772443787Rat
152025224Bw193Body weight QTL 1936.47body mass (VT:0001259)105216243375582749Rat
631552Vetf2Vascular elastic tissue fragility QTL 24.50.0002aorta elastic tissue integrity trait (VT:0010556)artery internal elastic lamina non-tumorous lesion count (CMO:0001913)103550938391417879Rat
631554Bp133Blood pressure QTL 1330.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)10125055464349221Rat
631557Bp136Blood pressure QTL 1360.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)105686844076129113Rat
61325Aia5Adjuvant induced arthritis QTL 50.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
2293679Bmd30Bone mineral density QTL 303.50.0001femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)102744378772443787Rat
1298078Stresp5Stress response QTL 52.990.00025blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1042546145107713808Rat
1578762Toxo1Toxoplasma gondii resistance QTL 1brain integrity trait (VT:0010579)percentage of study population displaying Toxoplasma gondii brain cysts at a point in time (CMO:0002028)105269900459876693Rat
2298544Neuinf9Neuroinflammation QTL 94.6nervous system integrity trait (VT:0010566)spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)101993920764939207Rat
61332Eau3Experimental allergic uveoretinitis QTL 30.004uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)101803578263035782Rat
70164Bw21Body weight QTL 214.360.00005body mass (VT:0001259)body weight (CMO:0000012)105429633699451733Rat
61463Bp12Blood pressure QTL 126.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)104183127886831278Rat
1579919Bp281Blood pressure QTL 2810.01arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)105046480295464802Rat
8694173Bw149Body weight QTL 1494.380.001body mass (VT:0001259)body weight gain (CMO:0000420)104493935989939359Rat
2300218Hpcl2Hepatic cholesterol level QTL 2liver cholesterol amount (VT:0010498)liver cholesterol level (CMO:0001597)104552916496099749Rat
70171Cari1Carrageenan-induced inflammation QTL 14.90.0005hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)1054296227107713808Rat
1598852Anxrr19Anxiety related response QTL 195.07body movement coordination trait (VT:0005424)number of rearing movements in an experimental apparatus (CMO:0001752)101866841963668419Rat
1581497Esta1Estrogen-induced thymic atrophy QTL 1thymus mass (VT:0004954)thymus wet weight (CMO:0000855)102183375861843633Rat
10450493Bp382Blood pressure QTL 3820.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)105086028895860288Rat
724527Bp148Blood pressure QTL 1480.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)102895035373950353Rat
1358897Stresp6Stress response QTL 64.170.022blood norepinephrine amount (VT:0005663)plasma norepinephrine level (CMO:0001010)103589326364653589Rat
1331762Rf40Renal function QTL 403.873kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)102980091064653589Rat
2300171Bmd58Bone mineral density QTL 584.90.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)102744378772443787Rat
61354Pia10Pristane induced arthritis QTL 100.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
2301967Cm73Cardiac mass QTL 734.55heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)101499153586964295Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)14282327487823274Rat
9589030Epfw9Epididymal fat weight QTL 919.240.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)104493935989939359Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014991535107556066Rat
2293652Bmd22Bone mineral density QTL 224.90.0001femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)102744378772443787Rat
70198BpQTLcluster9Blood pressure QTL cluster 92.94arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)104282327487823274Rat
2306787Ean3Experimental allergic neuritis QTL 33.1nervous system integrity trait (VT:0010566)body weight loss (CMO:0001399)105429622767476781Rat
724556Pur2Proteinuria QTL 25.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)102293137391127454Rat
8662860Vetf10Vascular elastic tissue fragility QTL 10artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)10666092373950353Rat
2306792Ean4Experimental allergic neuritis QTL 44nervous system integrity trait (VT:0010566)IFNG-secreting splenocyte count (CMO:0002122)104949549294495492Rat
61387Bp1Blood pressure QTL 15.1arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1052269185107713808Rat
1354585Eae18aExperimental allergic encephalomyelitis QTL 18a7.50.0004nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)105429622758944345Rat
70223Bp57Blood pressure QTL 575arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)101465354159653541Rat
1354587Kidm21Kidney mass QTL 213.3kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)101553301273695498Rat
634329Pia15Pristane induced arthritis QTL 153.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)102466212373695339Rat
70224Eae3Experimental allergic encephalomyelitis QTL 34.1nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)102702353561843633Rat
2298480Eau7Experimental allergic uveoretinitis QTL 70.0049uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)103550938380509383Rat
1331791Cm31Cardiac mass QTL 313.84606heart mass (VT:0007028)heart wet weight (CMO:0000069)102980091091417879Rat
2298495Eae23Experimental allergic encephalomyelitis QTL 2316.93nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis duration (CMO:0001424)101617552561175525Rat
2313087Bmd80Bone mineral density QTL 803.20.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)102011061465110614Rat
631530Tls3T-lymphoma susceptibility QTL 300.0001thymus integrity trait (VT:0010555)percentage of study population developing T-cell lymphomas during a period of time (CMO:0001911)102758722696099902Rat
2289985Bp305Blood pressure QTL 305arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)102907697874076978Rat
1354608Cm33Cardiac mass QTL 332.8heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)105530797293608131Rat
631532Cm50Cardiac mass QTL 506.6heart mass (VT:0007028)calculated heart weight (CMO:0000073)101803578263035782Rat
8552805Bw145Body weight QTL 1452.2body mass (VT:0001259)change in body weight to body weight ratio (CMO:0002216)104360879388608793Rat
631267Cia20Collagen induced arthritis QTL 203.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
2293705Bmd25Bone mineral density QTL 257.10.0001femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)102744378772443787Rat
631269Cia22Collagen induced arthritis QTL 228.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040535708107713808Rat
1576308Schws1Schwannoma susceptibility QTL 10.0041nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)1040535708107713808Rat
631268Cia21Collagen induced arthritis QTL 213.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1014991535107713808Rat
7207811Bmd90Bone mineral density QTL 905.2femur size trait (VT:1000369)femoral neck cross-sectional area (CMO:0001697)104994371094943710Rat
1576311Pia26Pristane induced arthritis QTL 26joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)103112911376129113Rat
631270Cia23Collagen induced arthritis QTL 233.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040535708107713808Rat
7411614Foco18Food consumption QTL 180.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)104493935989939359Rat
631547Bp87Blood pressure QTL 874.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)104786912992869129Rat
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10686461896620484Rat
12880050Am10Aortic mass QTL 100.016aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)103950348784503487Rat
2292436Bp310Blood pressure QTL 310arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)105060467795604677Rat
6893342Cm78Cardiac mass QTL 780.10.88heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)103550938388177745Rat
2313055Bw96Body weight QTL 963.60.0001body mass (VT:0001259)body weight (CMO:0000012)102011061465110614Rat
631542Bp82Blood pressure QTL 826.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)102702353599451848Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 63 161 91 90 59 92 59 6 352 188 11 140 81 92 31 15 15

Sequence


Ensembl Acc Id: ENSRNOT00000056551   ⟹   ENSRNOP00000053391
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1057,415,658 - 57,428,348 (+)Ensembl
mRatBN7.2 Ensembl1056,917,121 - 56,929,770 (+)Ensembl
Rnor_6.0 Ensembl1058,860,940 - 58,873,674 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000074523   ⟹   ENSRNOP00000065551
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1057,415,658 - 57,428,348 (+)Ensembl
mRatBN7.2 Ensembl1056,917,121 - 56,929,770 (+)Ensembl
Rnor_6.0 Ensembl1058,860,940 - 58,873,674 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000118013   ⟹   ENSRNOP00000078994
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1057,416,758 - 57,424,287 (+)Ensembl
mRatBN7.2 Ensembl1056,918,201 - 56,926,429 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000124321   ⟹   ENSRNOP00000112623
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1057,415,665 - 57,428,349 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000128699   ⟹   ENSRNOP00000099495
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1057,415,658 - 57,425,955 (+)Ensembl
RefSeq Acc Id: NM_001398875   ⟹   NP_001385804
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81057,415,935 - 57,428,348 (+)NCBI
mRatBN7.21056,917,378 - 56,929,791 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001385804 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDM05101 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000053391
  ENSRNOP00000053391.5
  ENSRNOP00000065551.2
  ENSRNOP00000078994.1
  ENSRNOP00000099495.1
  ENSRNOP00000112623.1
Ensembl Acc Id: ENSRNOP00000053391   ⟸   ENSRNOT00000056551
Ensembl Acc Id: ENSRNOP00000065551   ⟸   ENSRNOT00000074523
Ensembl Acc Id: ENSRNOP00000078994   ⟸   ENSRNOT00000118013
RefSeq Acc Id: NP_001385804   ⟸   NM_001398875
- UniProtKB: A6HGE6 (UniProtKB/TrEMBL),   D3ZPQ3 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000112623   ⟸   ENSRNOT00000124321
Ensembl Acc Id: ENSRNOP00000099495   ⟸   ENSRNOT00000128699
Protein Domains
TRAFD1/XAF1 zinc finger   XIAP-associated factor 1 C-terminal

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZPQ3-F1-model_v2 AlphaFold D3ZPQ3 1-273 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13697396
Promoter ID:EPDNEW_R7911
Type:initiation region
Name:Xaf1_1
Description:XIAP associated factor 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01058,860,887 - 58,860,947EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1585988 AgrOrtholog
BioCyc Gene G2FUF-24368 BioCyc
Ensembl Genes ENSRNOG00000037371 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000056551 ENTREZGENE
  ENSRNOT00000056551.6 UniProtKB/TrEMBL
  ENSRNOT00000074523.4 UniProtKB/TrEMBL
  ENSRNOT00000118013.2 UniProtKB/TrEMBL
  ENSRNOT00000124321.1 UniProtKB/TrEMBL
  ENSRNOT00000128699.1 UniProtKB/TrEMBL
Gene3D-CATH 3.30.40.10 UniProtKB/TrEMBL
  6.10.250.1730 UniProtKB/TrEMBL
InterPro Innate_Immune_Apopt_Reg UniProtKB/TrEMBL
  TRAFD1-XIAF1_Znf UniProtKB/TrEMBL
  XAF1 UniProtKB/TrEMBL
  XAF1_C UniProtKB/TrEMBL
  Znf_RING/FYVE/PHD UniProtKB/TrEMBL
NCBI Gene 679600 ENTREZGENE
PANTHER PTHR16295:SF17 UniProtKB/TrEMBL
  TRAF-TYPE ZINC FINGER PROTEIN-RELATED UniProtKB/TrEMBL
Pfam TRAFD1-XIAF1_ZnF UniProtKB/TrEMBL
  XAF1_C UniProtKB/TrEMBL
  Znf_XAF1_N UniProtKB/TrEMBL
PhenoGen Xaf1 PhenoGen
RatGTEx ENSRNOG00000037371 RatGTEx
Superfamily-SCOP TRAF domain-like UniProtKB/TrEMBL
UniProt A0A8I5ZLW0_RAT UniProtKB/TrEMBL
  A0ABK0KXY8_RAT UniProtKB/TrEMBL
  A0ABK0M5E1_RAT UniProtKB/TrEMBL
  A6HGE6 ENTREZGENE, UniProtKB/TrEMBL
  D3ZPQ3 ENTREZGENE, UniProtKB/TrEMBL
  M0R7W3_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-02-03 Xaf1  XIAP associated factor 1  XAF1  XIAP associated factor-1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-05 XAF1  XIAP associated factor-1  LOC679600  similar to XIAP associated factor-1 isoform 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-11-19 LOC679600  similar to XIAP associated factor-1 isoform 2      Symbol and Name status set to provisional 70820 PROVISIONAL