Tpmt (thiopurine S-methyltransferase) - Rat Genome Database

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Gene: Tpmt (thiopurine S-methyltransferase) Rattus norvegicus
Analyze
Symbol: Tpmt
Name: thiopurine S-methyltransferase
RGD ID: 1585162
Description: Predicted to enable S-adenosyl-L-methionine binding activity and thiopurine S-methyltransferase activity. Involved in response to testosterone. Predicted to be located in cytoplasm. Human ortholog(s) of this gene implicated in acute lymphoblastic leukemia; alopecia; leukopenia; and poor metabolism of thiopurines 1. Orthologous to human TPMT (thiopurine S-methyltransferase); PARTICIPATES IN azathioprine pharmacodynamics pathway; mercaptopurine pharmacodynamics pathway; mercaptopurine pharmacokinetics pathway; INTERACTS WITH (+)-schisandrin B; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC690050; similar to Thiopurine S-methyltransferase (Thiopurine methyltransferase); thiopurine methyltransferase
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81717,850,308 - 17,868,976 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1717,850,279 - 17,868,976 (+)EnsemblGRCr8
mRatBN7.21717,644,088 - 17,662,709 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1717,644,173 - 17,662,709 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1717,529,367 - 17,547,810 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01719,133,224 - 19,151,667 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01717,456,484 - 17,474,931 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01718,029,090 - 18,047,716 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1718,029,124 - 18,047,714 (+)Ensemblrn6Rnor6.0
Rnor_5.01719,889,509 - 19,908,063 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41723,697,900 - 23,714,173 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1717,356,338 - 17,372,611 (+)NCBICelera
Cytogenetic Map17p14NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(1->4)-beta-D-glucan  (ISO)
1,1-dichloroethene  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-hydroxypropanoic acid  (ISO)
3,7-dihydropurine-6-thione  (ISO)
3-chloropropane-1,2-diol  (EXP)
4,4'-sulfonyldiphenol  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP)
8-Br-cAMP  (ISO)
aconitine  (EXP)
acrylamide  (EXP)
alpha-Zearalanol  (EXP)
amitrole  (EXP)
ammonium chloride  (EXP)
antirheumatic drug  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
azathioprine  (ISO)
Azoxymethane  (ISO)
bendroflumethiazide  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
Butylbenzyl phthalate  (ISO)
carbon nanotube  (ISO)
chlorpyrifos  (ISO)
cisplatin  (ISO)
clofibrate  (ISO)
cobalt dichloride  (EXP)
cyclosporin A  (ISO)
dextran sulfate  (ISO)
diarsenic trioxide  (ISO)
Dibutyl phosphate  (ISO)
dicrotophos  (ISO)
dicyclanil  (ISO)
diethylstilbestrol  (ISO)
diuron  (EXP)
ethanol  (ISO)
folic acid  (ISO)
FR900359  (ISO)
furan  (EXP)
furosemide  (ISO)
gentamycin  (EXP)
glyphosate  (ISO)
inulin  (ISO)
iodide salt  (EXP)
irinotecan  (ISO)
ivermectin  (ISO)
ketoconazole  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
mercaptopurine  (ISO)
methidathion  (ISO)
methimazole  (EXP)
methotrexate  (ISO)
nickel dichloride  (EXP)
nitrofen  (EXP)
oxaliplatin  (EXP)
ozone  (ISO)
paracetamol  (EXP,ISO)
parathion  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenobarbital  (ISO)
pirinixic acid  (ISO)
propiconazole  (EXP)
Propiverine  (EXP)
purine-6-thiol  (ISO)
rac-lactic acid  (ISO)
resveratrol  (ISO)
S-adenosyl-L-methioninate  (ISO)
S-adenosyl-L-methionine  (ISO)
senecionine  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
sulfadimethoxine  (EXP)
sunitinib  (ISO)
temozolomide  (ISO)
tetrachloromethane  (EXP,ISO)
thapsigargin  (EXP)
theophylline  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
topotecan  (EXP)
trichlormethiazide  (ISO)
trichostatin A  (ISO)
triphenyl phosphate  (ISO)
triptonide  (ISO)
troglitazone  (EXP,ISO)
valproic acid  (ISO)
vancomycin  (ISO)
vinclozolin  (EXP)
vorinostat  (ISO)
zearalenone  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IEA)

References

References - curated
# Reference Title Reference Citation
1. Thiopurine methyltransferase genotyping in Palestinian childhood acute lymphoblastic leukemia patients. Ayesh BM, etal., BMC Hematol. 2013 Apr 10;13(1):3. doi: 10.1186/2052-1839-13-3.
2. Association of thiopurine methyltransferase status with azathioprine side effects in Chinese patients with systemic lupus erythematosus. Chen D, etal., Clin Rheumatol. 2014 Apr;33(4):499-503. doi: 10.1007/s10067-013-2441-x. Epub 2013 Dec 10.
3. Analysis of thiopurine S-methyltransferase polymorphism in the population of Serbia and Montenegro and mercaptopurine therapy tolerance in childhood acute lymphoblastic leukemia. Dokmanovic L, etal., Ther Drug Monit. 2006 Dec;28(6):800-6.
4. Epistatic interactions between thiopurine methyltransferase (TPMT) and inosine triphosphate pyrophosphatase (ITPA) variations determine 6-mercaptopurine toxicity in Indian children with acute lymphoblastic leukemia. Dorababu P, etal., Eur J Clin Pharmacol. 2012 Apr;68(4):379-87. doi: 10.1007/s00228-011-1133-1. Epub 2011 Oct 19.
5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6. Thiopurine methyltransferase (TPMT) activity and adverse effects of azathioprine in inflammatory bowel disease: long-term follow-up study of 394 patients. Gisbert JP, etal., Am J Gastroenterol. 2006 Dec;101(12):2769-76. Epub 2006 Oct 6.
7. Thiopurine methyltransferase regulation in rat kidney: immunoprecipitation studies. Hernandez JS, etal., Xenobiotica. 1991 Apr;21(4):451-9.
8. Influences of thiopurine methyltransferase genotype and activity on thiopurine-induced leukopenia in Korean patients with inflammatory bowel disease: a retrospective cohort study. Kim JH, etal., J Clin Gastroenterol. 2010 Nov-Dec;44(10):e242-8. doi: 10.1097/MCG.0b013e3181d6baf5.
9. The impact of thiopurine s-methyltransferase polymorphism on azathioprine-induced myelotoxicity in renal transplant recipients. Kurzawski M, etal., Ther Drug Monit. 2005 Aug;27(4):435-41.
10. TPMT genetic variants are associated with increased rejection with azathioprine use in heart transplantation. Liang JJ, etal., Pharmacogenet Genomics. 2013 Dec;23(12):658-65. doi: 10.1097/FPC.0000000000000005.
11. Effect of S-adenosylhomocysteine on sulfhydryl xenobiotic transmethylases in rat liver. Loo G and Smith JT, Biochem Biophys Res Commun. 1985 Apr 30;128(2):965-71.
12. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
13. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
14. GOA pipeline RGD automated data pipeline
15. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
16. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
17. Comprehensive gene review and curation RGD comprehensive gene curation
Additional References at PubMed
PMID:657528   PMID:9539138   PMID:10548451   PMID:11751462   PMID:11810420   PMID:11845325   PMID:11958524   PMID:12477932   PMID:15056293   PMID:15489334   PMID:18484748   PMID:19535798  
PMID:23376485  


Genomics

Comparative Map Data
Tpmt
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81717,850,308 - 17,868,976 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1717,850,279 - 17,868,976 (+)EnsemblGRCr8
mRatBN7.21717,644,088 - 17,662,709 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1717,644,173 - 17,662,709 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1717,529,367 - 17,547,810 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01719,133,224 - 19,151,667 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01717,456,484 - 17,474,931 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01718,029,090 - 18,047,716 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1718,029,124 - 18,047,714 (+)Ensemblrn6Rnor6.0
Rnor_5.01719,889,509 - 19,908,063 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41723,697,900 - 23,714,173 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1717,356,338 - 17,372,611 (+)NCBICelera
Cytogenetic Map17p14NCBI
TPMT
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38618,128,311 - 18,155,169 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl618,128,311 - 18,155,348 (-)Ensemblhg38GRCh38
GRCh37618,128,542 - 18,155,400 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36618,236,521 - 18,263,353 (-)NCBIBuild 36Build 36hg18NCBI36
Build 34618,059,377 - 18,263,263NCBI
Celera619,366,550 - 19,393,384 (-)NCBICelera
Cytogenetic Map6p22.3NCBI
HuRef618,072,922 - 18,099,749 (-)NCBIHuRef
CHM1_1618,131,149 - 18,157,981 (-)NCBICHM1_1
T2T-CHM13v2.0618,000,482 - 18,027,339 (-)NCBIT2T-CHM13v2.0
Tpmt
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391347,175,463 - 47,196,833 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1347,175,958 - 47,198,213 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381347,021,987 - 47,043,338 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1347,022,482 - 47,044,737 (-)Ensemblmm10GRCm38
MGSCv371347,118,912 - 47,138,586 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361347,036,149 - 47,054,175 (-)NCBIMGSCv36mm8
Celera1348,108,353 - 48,127,836 (-)NCBICelera
Cytogenetic Map13A5NCBI
cM Map1324.5NCBI
Tpmt
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554838,052,849 - 8,072,764 (+)Ensembl
ChiLan1.0NW_0049554838,052,867 - 8,072,235 (+)NCBIChiLan1.0ChiLan1.0
TPMT
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2532,789,158 - 32,814,471 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1628,774,422 - 28,799,772 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0617,977,544 - 18,002,839 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1618,330,000 - 18,355,201 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl618,330,000 - 18,355,157 (-)EnsemblpanPan2panpan1.1
TPMT
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13516,928,991 - 16,953,891 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3516,929,240 - 16,953,229 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha3516,879,116 - 16,902,874 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.03517,035,847 - 17,060,453 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3517,035,872 - 17,060,446 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13516,849,193 - 16,872,898 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03516,906,511 - 16,930,057 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03518,237,408 - 18,261,325 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Tpmt
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244049467,813,141 - 7,831,506 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365523,897,375 - 3,917,772 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365523,899,445 - 3,917,774 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TPMT
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl713,820,866 - 13,846,012 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1713,821,656 - 13,846,107 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2714,563,347 - 14,587,813 (-)NCBISscrofa10.2Sscrofa10.2susScr3
TPMT
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11753,987,561 - 54,012,647 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1753,987,559 - 54,014,650 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604418,353,974 - 18,379,216 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tpmt
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247568,511,315 - 8,531,745 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247568,511,275 - 8,532,100 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Tpmt
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11466,018,278 - 66,036,277 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Tpmt
152 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:35
Count of miRNA genes:30
Interacting mature miRNAs:35
Transcripts:ENSRNOT00000022085
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1354581Bp247Blood pressure QTL 2474.5arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)17143999106Rat
2300002Iddm36Insulin dependent diabetes mellitus QTL 361.98blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)17926675540968173Rat
2293664Bmd28Bone mineral density QTL 285.10.0001femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)17436005727233623Rat
8552966Pigfal18Plasma insulin-like growth factor 1 level QTL 188.7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)171286094257860942Rat
1300123Bp194Blood pressure QTL 1942.82arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)17212084342054133Rat
1582224Epfw4Epididymal fat weight QTL 43.50.0058epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)17920650523859062Rat
1582225Bw67Body weight QTL 676.20.0001body mass (VT:0001259)body weight (CMO:0000012)17920650523859062Rat
2302377Scl61Serum cholesterol level QTL 614.36blood HDL cholesterol amount (VT:0000184)serum high density lipoprotein cholesterol level (CMO:0000361)17622199858177198Rat
1582226Bw64Body weight QTL 644.20.0017body mass (VT:0001259)body weight (CMO:0000012)17920650523859062Rat
9589151Insul30Insulin level QTL 308.820.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)171286094257860942Rat
10401807Kidm52Kidney mass QTL 52kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)17131706603Rat
10054088Scort28Serum corticosterone level QTL 282.040.0102blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)17473353449733534Rat
9589057Scfw6Subcutaneous fat weight QTL 68.620.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)171286094257860942Rat
1582208Kidm32Kidney mass QTL 323.90.0018kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)17920650523859062Rat
9590154Scort9Serum corticosterone level QTL 923.570.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)171286094257860942Rat
9590088Insglur7Insulin/glucose ratio QTL 720.380.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)171286094257860942Rat
1549900Iddm20Insulin dependent diabetes mellitus QTL 203.7pancreas integrity trait (VT:0010560)percentage of study population developing diabetes mellitus during a period of time (CMO:0001114)17122181410Rat
1331720Rf43Renal function QTL 432.881kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)171553702528637951Rat
2317053Aia25Adjuvant induced arthritis QTL 252.69joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)171060469455604694Rat
1354613Kidm14Kidney mass QTL 146.2kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)17136045694Rat
1331765Hrtrt15Heart rate QTL 154.094heart pumping trait (VT:2000009)heart rate (CMO:0000002)171553702560531414Rat
7411666Foco31Food consumption QTL 3111.40.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)171286094257860942Rat
2324619Coatc4Coat color QTL 40.001coat/hair pigmentation trait (VT:0010463)pigmented dorsal coat/hair area to total dorsal coat/hair area ratio (CMO:0001811)17121499218Rat
2303627Vencon8Ventilatory control QTL 80.001respiration trait (VT:0001943)tidal volume (CMO:0000222)17473353449733534Rat
70184BpQTLcluster14Blood pressure QTL cluster 143.38arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)17857434232199534Rat
1582258Bw76Body weight QTL 764.60.0005body mass (VT:0001259)body weight (CMO:0000012)17920650523859062Rat
631207Niddm41Non-insulin dependent diabetes mellitus QTL 41blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)17138037084Rat
1582199Insul5Insulin level QTL 53.40.0119blood insulin amount (VT:0001560)calculated serum insulin level (CMO:0000359)17920650523859062Rat
1354662Rf49Renal function QTL 492.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)17143999106Rat
2293648Bmd31Bone mineral density QTL 314.50.0001femur size trait (VT:1000369)femoral neck cortical cross-sectional area (CMO:0001702)17436005727233623Rat
1354658Spl8Serum phospholipid level QTL 83.8blood VLDL phospholipid amount (VT:0010507)blood very low density lipoprotein phospholipid level (CMO:0001571)17143999106Rat
1641902Colcr7Colorectal carcinoma resistance QTL 73.350.0044intestine integrity trait (VT:0010554)benign colorectal tumor surface area measurement (CMO:0001799)17212084322087569Rat
1582241Bw70Body weight QTL 704.60.0003body mass (VT:0001259)body weight (CMO:0000012)17920650523859062Rat
1582245Bw73Body weight QTL 734.60.0004body mass (VT:0001259)body weight (CMO:0000012)17920650523859062Rat
9590316Scort21Serum corticosterone level QTL 214.750.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)17122877318Rat

Markers in Region
RH130497  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21717,662,508 - 17,662,688 (+)MAPPERmRatBN7.2
Rnor_6.01718,047,516 - 18,047,695NCBIRnor6.0
Rnor_5.01719,889,530 - 19,889,709UniSTSRnor5.0
RGSC_v3.41723,714,188 - 23,714,367UniSTSRGSC3.4
Celera1717,372,626 - 17,372,805UniSTS
RH 3.4 Map17194.7UniSTS
Cytogenetic Map17p13UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000022085   ⟹   ENSRNOP00000022084
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1717,850,279 - 17,868,974 (+)Ensembl
mRatBN7.2 Ensembl1717,644,173 - 17,662,705 (+)Ensembl
Rnor_6.0 Ensembl1718,029,124 - 18,047,714 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000081708   ⟹   ENSRNOP00000072177
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1717,850,279 - 17,868,974 (+)Ensembl
mRatBN7.2 Ensembl1717,644,173 - 17,662,705 (+)Ensembl
Rnor_6.0 Ensembl1718,031,228 - 18,047,495 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000096156   ⟹   ENSRNOP00000081418
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1717,852,715 - 17,868,976 (+)Ensembl
mRatBN7.2 Ensembl1717,646,197 - 17,662,709 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000156507   ⟹   ENSRNOP00000106489
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1717,852,528 - 17,868,761 (+)Ensembl
RefSeq Acc Id: NM_001395670   ⟹   NP_001382599
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81717,850,426 - 17,868,976 (+)NCBI
mRatBN7.21717,644,158 - 17,662,709 (+)NCBI
RefSeq Acc Id: XM_039096087   ⟹   XP_038952015
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81717,850,308 - 17,860,715 (+)NCBI
mRatBN7.21717,644,088 - 17,655,058 (+)NCBI
RefSeq Acc Id: XM_039096088   ⟹   XP_038952016
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81717,850,308 - 17,860,715 (+)NCBI
mRatBN7.21717,644,094 - 17,654,277 (+)NCBI
Ensembl Acc Id: ENSRNOP00000022084   ⟸   ENSRNOT00000022085
Ensembl Acc Id: ENSRNOP00000072177   ⟸   ENSRNOT00000081708
RefSeq Acc Id: XP_038952015   ⟸   XM_039096087
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038952016   ⟸   XM_039096088
- Peptide Label: isoform X2
Ensembl Acc Id: ENSRNOP00000081418   ⟸   ENSRNOT00000096156
RefSeq Acc Id: NP_001382599   ⟸   NM_001395670
- UniProtKB: Q9Z0T0 (UniProtKB/Swiss-Prot),   B0BMT6 (UniProtKB/TrEMBL),   A0A0G2K2B6 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000106489   ⟸   ENSRNOT00000156507

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9Z0T0-F1-model_v2 AlphaFold Q9Z0T0 1-240 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13700366
Promoter ID:EPDNEW_R10889
Type:multiple initiation site
Name:Tpmt_1
Description:thiopurine S-methyltransferase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01718,029,216 - 18,029,276EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1585162 AgrOrtholog
BioCyc Gene G2FUF-9909 BioCyc
Ensembl Genes ENSRNOG00000016468 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000022085 ENTREZGENE
Gene3D-CATH 3.40.50.150 UniProtKB/Swiss-Prot
InterPro SAM-dependent_MTases UniProtKB/Swiss-Prot
  Thiopurine_S-MeTrfase UniProtKB/Swiss-Prot
  TPMT UniProtKB/Swiss-Prot
NCBI Gene 690050 ENTREZGENE
PANTHER THIOPURINE S-METHYLTRANSFERASE UniProtKB/Swiss-Prot
  THIOPURINE S-METHYLTRANSFERASE UniProtKB/Swiss-Prot
Pfam TPMT UniProtKB/Swiss-Prot
PharmGKB TPMT RGD
PhenoGen Tpmt PhenoGen
PIRSF Thiopurine_S-methyltransferase UniProtKB/Swiss-Prot
PROSITE SAM_MT_TPMT UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000016468 RatGTEx
Superfamily-SCOP SSF53335 UniProtKB/Swiss-Prot
UniProt A0A0G2K2B6 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5ZSG8_RAT UniProtKB/TrEMBL
  A0ABK0LVZ0_RAT UniProtKB/TrEMBL
  B0BMT6 ENTREZGENE, UniProtKB/TrEMBL
  Q7TP19_RAT UniProtKB/TrEMBL
  Q9Z0T0 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-05-24 Tpmt  thiopurine S-methyltransferase  LOC681730  similar to Thiopurine S-methyltransferase (Thiopurine methyltransferase)  Data merged from RGD:1591672 1643240 APPROVED
2008-03-03 Tpmt  thiopurine S-methyltransferase  Tpmt  thiopurine methyltransferase  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2007-09-11 Tpmt  thiopurine methyltransferase  LOC690050  similar to Thiopurine S-methyltransferase (Thiopurine methyltransferase)  Symbol and Name updated to reflect Human and Mouse nomenclature 1299863 APPROVED
2006-11-20 LOC681730  similar to Thiopurine S-methyltransferase (Thiopurine methyltransferase)      Symbol and Name status set to provisional 70820 PROVISIONAL
2006-11-19 LOC690050  similar to Thiopurine S-methyltransferase (Thiopurine methyltransferase)      Symbol and Name status set to provisional 70820 PROVISIONAL