Sp3 (Sp3 transcription factor) - Rat Genome Database

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Gene: Sp3 (Sp3 transcription factor) Rattus norvegicus
Analyze
Symbol: Sp3
Name: Sp3 transcription factor
RGD ID: 1583765
Description: Predicted to enable several functions, including DNA-binding transcription repressor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and RNA polymerase II-specific DNA-binding transcription factor binding activity. Predicted to be involved in negative regulation of DNA-templated transcription and positive regulation of transcription by RNA polymerase II. Predicted to act upstream of or within several processes, including embryo development; embryonic camera-type eye morphogenesis; and hemopoiesis. Predicted to be located in nucleus. Predicted to be part of transcription repressor complex. Orthologous to human SP3 (Sp3 transcription factor); INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 7,12-dimethyltetraphene.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC103691822; Sp3 transcription factor (mapped); Sp3_mapped; trans-acting transcription factor 3; transcription factor Sp3; uncharacterized LOC103691822
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8378,219,421 - 78,272,318 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl378,219,426 - 78,264,517 (-)EnsemblGRCr8
mRatBN7.2357,811,855 - 57,857,150 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl357,812,075 - 57,860,342 (-)EnsemblmRatBN7.2
Rnor_6.0359,644,579 - 59,689,011 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl359,646,015 - 59,688,692 (-)Ensemblrn6Rnor6.0
Rnor_5.0366,729,636 - 66,739,419 (-)NCBIRnor_5.0Rnor_5.0rn5
Rnor_5.0366,118,151 - 66,163,940 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4355,440,985 - 55,485,768 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera357,350,925 - 57,387,172 (-)NCBICelera
Cytogenetic Map3q23NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (ISO)
1,2-dimethylhydrazine  (ISO)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-methylcholine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-fluorouracil  (ISO)
7,12-dimethyltetraphene  (EXP)
aflatoxin B1  (ISO)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
arsenous acid  (ISO)
benzene  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
biotin  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
camptothecin  (ISO)
carbamazepine  (ISO)
CGP 52608  (ISO)
chlorpyrifos  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
cordycepin  (ISO)
coumarin  (ISO)
crocidolite asbestos  (ISO)
curcumin  (ISO)
daunorubicin  (ISO)
decabromodiphenyl ether  (EXP)
diarsenic trioxide  (ISO)
Dibutyl phosphate  (ISO)
dichloromethane  (ISO)
dicrotophos  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
enzyme inhibitor  (ISO)
fenvalerate  (EXP)
fluoranthene  (ISO)
folic acid  (ISO)
FR900359  (ISO)
fulvestrant  (ISO)
gentamycin  (EXP)
glutathione  (ISO)
gold atom  (ISO)
gold(0)  (ISO)
homocysteic acid  (ISO)
hydrogen peroxide  (ISO)
L-ascorbic acid  (ISO)
lead nitrate  (ISO)
lead(0)  (ISO)
leflunomide  (ISO)
MC1568  (ISO)
metformin  (ISO)
methotrexate  (ISO)
methylmercury chloride  (ISO)
mithramycin SK  (ISO)
N,N-diethyl-m-toluamide  (EXP)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
nickel sulfate  (ISO)
nitrates  (ISO)
paraquat  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
permethrin  (EXP)
phenobarbital  (ISO)
phenytoin  (ISO)
pirinixic acid  (ISO)
potassium dichromate  (ISO)
promegestone  (ISO)
quercetin  (ISO)
quercetin 3-O-beta-D-galactopyranoside  (ISO)
resveratrol  (ISO)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (ISO)
S-nitrosoglutathione  (ISO)
SB 431542  (ISO)
Se-methyl-L-selenocysteine  (ISO)
Se-methylselenocysteine  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
tamoxifen  (ISO)
tetrathiomolybdate(2-)  (ISO)
titanium dioxide  (ISO)
trichostatin A  (ISO)
triphenyl phosphate  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
vorinostat  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
nucleoplasm  (IEA,ISO)
nucleus  (IBA,IDA,IEA,ISO)
transcription repressor complex  (IDA,IEA,ISO)

References

References - curated
# Reference Title Reference Citation
1. Co-operative interactions between NFAT (nuclear factor of activated T cells) c1 and the zinc finger transcription factors Sp1/Sp3 and Egr-1 regulate MT1-MMP (membrane type 1 matrix metalloproteinase) transcription by glomerular mesangial cells. Alfonso-Jaume MA, etal., Biochem J. 2004 Jun 15;380(Pt 3):735-47.
2. Cooperation of Sp1 and p300 in the induction of the CDK inhibitor p21WAF1/CIP1 during NGF-mediated neuronal differentiation. Billon N, etal., Oncogene. 1999 May 6;18(18):2872-82. doi: 10.1038/sj.onc.1202712.
3. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, etal., Genome Res 1996 Sep;6(9):791-806.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Evidence of the neuron-restrictive silencer factor (NRSF) interaction with Sp3 and its synergic repression to the mu opioid receptor (MOR) gene. Kim CS, etal., Nucleic Acids Res. 2006;34(22):6392-403. Epub 2006 Nov 27.
6. Sp1 and Egr1 regulate transcription of the Dmrt1 gene in Sertoli cells. Lei N and Heckert LL, Biol Reprod 2002 Mar;66(3):675-84.
7. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12297531   PMID:12560508   PMID:12584202   PMID:12676787   PMID:12700237   PMID:12771217   PMID:14563703   PMID:14630713   PMID:15094381   PMID:15282343   PMID:15511642   PMID:15522233  
PMID:15572681   PMID:15721292   PMID:15817708   PMID:16378599   PMID:16403775   PMID:16460348   PMID:17379926   PMID:17584888   PMID:17670746   PMID:18004997   PMID:18275970   PMID:18348986  
PMID:19728174   PMID:19943855   PMID:20091743   PMID:20884886   PMID:21289081   PMID:23093703   PMID:25476526   PMID:30110572  


Genomics

Comparative Map Data
Sp3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8378,219,421 - 78,272,318 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl378,219,426 - 78,264,517 (-)EnsemblGRCr8
mRatBN7.2357,811,855 - 57,857,150 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl357,812,075 - 57,860,342 (-)EnsemblmRatBN7.2
Rnor_6.0359,644,579 - 59,689,011 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl359,646,015 - 59,688,692 (-)Ensemblrn6Rnor6.0
Rnor_5.0366,729,636 - 66,739,419 (-)NCBIRnor_5.0Rnor_5.0rn5
Rnor_5.0366,118,151 - 66,163,940 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4355,440,985 - 55,485,768 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera357,350,925 - 57,387,172 (-)NCBICelera
Cytogenetic Map3q23NCBI
SP3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382173,900,775 - 173,965,702 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2173,880,850 - 173,965,373 (-)Ensemblhg38GRCh38
GRCh372174,765,503 - 174,830,430 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362174,481,504 - 174,538,309 (-)NCBIBuild 36Build 36hg18NCBI36
Celera2168,384,626 - 168,443,931 (-)NCBICelera
Cytogenetic Map2q31.1NCBI
HuRef2166,650,849 - 166,709,905 (-)NCBIHuRef
CHM1_12174,778,156 - 174,837,417 (-)NCBICHM1_1
T2T-CHM13v2.02174,387,111 - 174,452,024 (-)NCBIT2T-CHM13v2.0
Sp3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39272,766,774 - 72,810,790 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl272,766,771 - 72,810,790 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38272,936,430 - 72,980,446 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl272,936,427 - 72,980,446 (-)Ensemblmm10GRCm38
MGSCv37272,774,487 - 72,818,503 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36272,737,269 - 72,789,548 (-)NCBIMGSCv36mm8
Celera274,621,937 - 74,665,927 (-)NCBICelera
Cytogenetic Map2C3NCBI
cM Map243.35NCBI
Sp3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049554491,347,781 - 1,404,368 (+)NCBIChiLan1.0ChiLan1.0
SP3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21376,573,271 - 76,630,819 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12B76,588,245 - 76,645,598 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B61,185,975 - 61,243,155 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B178,639,630 - 178,698,313 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B178,639,677 - 178,692,848 (-)EnsemblpanPan2panpan1.1
SP3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13618,023,750 - 18,086,995 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3618,024,627 - 18,077,587 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha3618,030,699 - 18,085,623 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.03618,154,210 - 18,209,148 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3618,152,355 - 18,209,033 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13618,234,479 - 18,289,351 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03618,232,972 - 18,287,863 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03618,336,948 - 18,391,940 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Sp3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303135,186,490 - 135,238,803 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365093,741,836 - 3,793,136 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365093,740,393 - 3,782,873 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SP3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1579,935,994 - 80,025,850 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11579,935,986 - 79,990,139 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21589,252,305 - 89,292,992 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SP3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11059,414,739 - 59,471,596 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1059,416,152 - 59,470,456 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_023666040140,106,666 - 140,163,017 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Sp3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462478711,144,581 - 11,193,520 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Sp3
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1550,283,240 - 50,326,974 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Sp3
332 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:9
Count of miRNA genes:8
Interacting mature miRNAs:8
Transcripts:ENSRNOT00000026148
Prediction methods:Miranda
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300178Hrtrt4Heart rate QTL 43.74heart pumping trait (VT:2000009)heart rate (CMO:0000002)351490129111359995Rat
61377Edpm3Estrogen-dependent pituitary mass QTL 37.050.038pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)373592611110333156Rat
1358293Bw38Body weight QTL 3860.0000031body mass (VT:0001259)body weight (CMO:0000012)374364268119364268Rat
1582238Bw68Body weight QTL 683.20.0064body mass (VT:0001259)body weight (CMO:0000012)373592512136118980Rat
1331795Rf30Renal function QTL 303.708urine potassium amount (VT:0010539)urine potassium level (CMO:0000128)35986366387321459Rat
1582239Epfw1Epididymal fat weight QTL 14.50.0006epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)373592512136118980Rat
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)351581665184004958Rat
1354589Bw31Body weight QTL 313.3body mass (VT:0001259)body weight (CMO:0000012)35365182698651826Rat
2303593Gluco46Glucose level QTL 463blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)34887661993876619Rat
1354590Despr11Despair related QTL 110.000031locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)34887661993876619Rat
2298542Neuinf11Neuroinflammation QTL 113.9nervous system integrity trait (VT:0010566)spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)33540319997383526Rat
2292591Esta4Estrogen-induced thymic atrophy QTL 4thymus mass (VT:0004954)thymus wet weight (CMO:0000855)367641776167835660Rat
1358362Srcrt2Stress Responsive Cort QTL 22.78blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)358601291153936591Rat
631832Sach1Saccharin preference QTL 12.70.02consumption behavior trait (VT:0002069)calculated saccharin drink intake volume (CMO:0001600)34790417292904172Rat
737818Hcar12Hepatocarcinoma resistance QTL 122.6liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)349872657138829559Rat
1582218Bw74Body weight QTL 743.90.0021body mass (VT:0001259)body weight (CMO:0000012)373592512136118980Rat
1331777Bw24Body weight QTL 243.503body mass (VT:0001259)body weight (CMO:0000012)35986366387321459Rat
631647Bp122Blood pressure QTL 1226.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)35109256196092561Rat
1300169Bp177Blood pressure QTL 1772.96arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)33642511681425116Rat
9590286Uminl1Urine mineral level QTL 13.50.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)34865774493657744Rat
724523Tsu1Thymus enlargement suppressive QTL 13.84thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)370845569136091483Rat
4889966Bss95Bone structure and strength QTL 954.4tibia area (VT:1000281)tibia-fibula cross-sectional area (CMO:0001718)33779691982796919Rat
2302276Bw82Body weight QTL 824.32body mass (VT:0001259)body weight (CMO:0000012)35986366383358329Rat
2292613Ept16Estrogen-induced pituitary tumorigenesis QTL 168.3pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)367641995130815812Rat
738019Anxrr10Anxiety related response QTL 103.9exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)358925062103925062Rat
631841Niddm39Non-insulin dependent diabetes mellitus QTL 393.36blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)370311536115311536Rat
9590136Scort3Serum corticosterone level QTL 323.370.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)34865774493657744Rat
61419Cia11Collagen induced arthritis QTL 115.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)35076614595766145Rat
61356Bp37Blood pressure QTL 373blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)35109256196092561Rat
1358905Hrtrt17Heart rate QTL 175.90.000014heart pumping trait (VT:2000009)heart rate (CMO:0000002)336721849110333156Rat
1558650Cm48Cardiac mass QTL 4840.0001heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)35076614595766145Rat
8694196Abfw2Abdominal fat weight QTL 216.580.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)34865774493657744Rat
1358885Bp251Blood pressure QTL 2513.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)31141509147Rat
1354597Kidm13Kidney mass QTL 132.9kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)342158111124558371Rat
1582249Bw77Body weight QTL 773.20.0025epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)37359251285062403Rat
2325840Bp345Blood pressure QTL 3450.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)33870893183708931Rat
8552950Pigfal12Plasma insulin-like growth factor 1 level QTL 127.3blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)34865774493657744Rat
631676Cm8Cardiac mass QTL 87.030.0001aorta mass (VT:0002845)aorta weight (CMO:0000076)33736373482363734Rat
2290452Scl56Serum cholesterol level QTL 562.26blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)33610140381101403Rat
8694386Bw159Body weight QTL 1594.520.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)34865774493657744Rat
1354604Bw36Body weight QTL 362.9body mass (VT:0001259)body weight (CMO:0000012)342158111124558371Rat
1358888Bp264Blood pressure QTL 2644.43arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)35675975141509147Rat
1358186Ept2Estrogen-induced pituitary tumorigenesis QTL 28.3pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)367641995130815812Rat

Markers in Region
RH140061  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2357,842,288 - 57,842,475 (+)MAPPERmRatBN7.2
Rnor_6.0359,674,822 - 59,675,008NCBIRnor6.0
Rnor_5.0366,148,466 - 66,148,652UniSTSRnor5.0
RGSC_v3.4355,471,263 - 55,471,449UniSTSRGSC3.4
Celera357,381,143 - 57,381,329UniSTS
Cytogenetic Map3q22UniSTS
PMC169877P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X63,886,820 - 63,887,358 (+)MAPPERmRatBN7.2
mRatBN7.2323,603,189 - 23,603,720 (+)MAPPERmRatBN7.2
Rnor_6.0324,171,597 - 24,172,127NCBIRnor6.0
Rnor_6.0X68,471,397 - 68,471,934NCBIRnor6.0
Rnor_5.0329,388,989 - 29,389,519UniSTSRnor5.0
Rnor_5.0X69,346,132 - 69,346,669UniSTSRnor5.0
RGSC_v3.4X86,814,796 - 86,815,333UniSTSRGSC3.4
RGSC_v3.4319,691,805 - 19,692,335UniSTSRGSC3.4
Celera322,015,742 - 22,016,272UniSTS
CeleraX64,275,723 - 64,276,260UniSTS
Cytogenetic Map3q22UniSTS
Cytogenetic MapXq31UniSTS
RH133751  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2357,816,724 - 57,816,906 (+)MAPPERmRatBN7.2
Rnor_6.0360,252,732 - 60,252,913NCBIRnor6.0
Rnor_6.0359,649,229 - 59,649,410NCBIRnor6.0
Rnor_5.0366,123,021 - 66,123,202UniSTSRnor5.0
Rnor_5.0366,734,506 - 66,734,687UniSTSRnor5.0
RGSC_v3.4355,445,855 - 55,446,036UniSTSRGSC3.4
Celera357,355,575 - 57,355,756UniSTS
Cytogenetic Map3q22UniSTS
PMC305603P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X63,885,649 - 63,885,862 (+)MAPPERmRatBN7.2
mRatBN7.2357,847,231 - 57,847,443 (+)MAPPERmRatBN7.2
Rnor_6.0359,679,764 - 59,679,975NCBIRnor6.0
Rnor_6.0X68,470,226 - 68,470,438NCBIRnor6.0
Rnor_5.0366,153,408 - 66,153,619UniSTSRnor5.0
Rnor_5.0X69,344,961 - 69,345,173UniSTSRnor5.0
RGSC_v3.4X86,813,625 - 86,813,837UniSTSRGSC3.4
RGSC_v3.4355,476,205 - 55,476,416UniSTSRGSC3.4
Celera357,386,085 - 57,386,296UniSTS
CeleraX64,274,552 - 64,274,764UniSTS
Cytogenetic Map3q22UniSTS
Cytogenetic MapXq31UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000078752   ⟹   ENSRNOP00000073478
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl378,219,426 - 78,264,517 (-)Ensembl
mRatBN7.2 Ensembl357,812,075 - 57,848,374 (-)Ensembl
Rnor_6.0 Ensembl359,646,015 - 59,688,692 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000103163   ⟹   ENSRNOP00000084927
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl378,219,426 - 78,264,517 (-)Ensembl
mRatBN7.2 Ensembl357,812,075 - 57,860,342 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000107886   ⟹   ENSRNOP00000090911
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl357,812,075 - 57,860,342 (-)Ensembl
RefSeq Acc Id: NM_001427405   ⟹   NP_001414334
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8378,219,421 - 78,264,517 (-)NCBI
RefSeq Acc Id: XM_039106378   ⟹   XP_038962306
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8378,219,641 - 78,268,361 (-)NCBI
mRatBN7.2357,811,855 - 57,857,150 (-)NCBI
RefSeq Acc Id: XM_039106379   ⟹   XP_038962307
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8378,219,641 - 78,268,337 (-)NCBI
mRatBN7.2357,811,855 - 57,856,460 (-)NCBI
RefSeq Acc Id: XM_063284295   ⟹   XP_063140365
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8378,219,641 - 78,268,363 (-)NCBI
RefSeq Acc Id: XM_063284296   ⟹   XP_063140366
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8378,219,641 - 78,272,318 (-)NCBI
RefSeq Acc Id: XM_063284297   ⟹   XP_063140367
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8378,219,641 - 78,268,363 (-)NCBI
RefSeq Acc Id: XR_005502231
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8378,229,029 - 78,268,598 (-)NCBI
mRatBN7.2357,821,463 - 57,857,150 (-)NCBI
RefSeq Acc Id: XR_010064675
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8378,223,684 - 78,268,394 (-)NCBI
Ensembl Acc Id: ENSRNOP00000073478   ⟸   ENSRNOT00000078752
RefSeq Acc Id: XP_038962306   ⟸   XM_039106378
- Peptide Label: isoform X2
- UniProtKB: A0A8I6AEE9 (UniProtKB/TrEMBL),   A0A0G2K5M1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038962307   ⟸   XM_039106379
- Peptide Label: isoform X3
- UniProtKB: A6HM81 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000084927   ⟸   ENSRNOT00000103163
Ensembl Acc Id: ENSRNOP00000090911   ⟸   ENSRNOT00000107886
RefSeq Acc Id: NP_001414334   ⟸   NM_001427405
- UniProtKB: A0A0G2K5M1 (UniProtKB/TrEMBL),   A0A8I6A0B6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063140366   ⟸   XM_063284296
- Peptide Label: isoform X1
- UniProtKB: A0A0G2K5M1 (UniProtKB/TrEMBL),   A0A8I6A0B6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063140365   ⟸   XM_063284295
- Peptide Label: isoform X1
- UniProtKB: A0A0G2K5M1 (UniProtKB/TrEMBL),   A0A8I6A0B6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063140367   ⟸   XM_063284297
- Peptide Label: isoform X1
- UniProtKB: A0A0G2K5M1 (UniProtKB/TrEMBL),   A0A8I6A0B6 (UniProtKB/TrEMBL)
Protein Domains
C2H2-type

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0A0G2K5M1-F1-model_v2 AlphaFold A0A0G2K5M1 1-714 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1583765 AgrOrtholog
BioCyc Gene G2FUF-49389 BioCyc
Ensembl Genes ENSRNOG00000060479 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000078752 ENTREZGENE
  ENSRNOT00000078752.3 UniProtKB/TrEMBL
  ENSRNOT00000103163 ENTREZGENE
  ENSRNOT00000103163.2 UniProtKB/TrEMBL
Gene3D-CATH Classic Zinc Finger UniProtKB/TrEMBL
InterPro Znf_C2H2/integrase_DNA-bd UniProtKB/TrEMBL
  Znf_C2H2_sf UniProtKB/TrEMBL
NCBI Gene 367846 ENTREZGENE
PANTHER KRUEPPEL-LIKE TRANSCRIPTION FACTOR UniProtKB/TrEMBL
  PTHR23235:SF3 UniProtKB/TrEMBL
Pfam zf-C2H2 UniProtKB/TrEMBL
PhenoGen Sp3 PhenoGen
PROSITE ZINC_FINGER_C2H2_1 UniProtKB/TrEMBL
  ZINC_FINGER_C2H2_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000060479 RatGTEx
SMART ZnF_C2H2 UniProtKB/TrEMBL
Superfamily-SCOP SSF57667 UniProtKB/TrEMBL
UniProt A0A0G2K5M1 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6A0B6 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AEE9 ENTREZGENE
  A6HM81 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Sp3  Sp3 transcription factor  LOC103691822  uncharacterized LOC103691822  Data merged from RGD:9330173 737654 PROVISIONAL
2014-08-25 LOC103691822  uncharacterized LOC103691822      Symbol and Name status set to provisional 70820 PROVISIONAL
2008-09-18 Sp3  Sp3 transcription factor  Sp3  trans-acting transcription factor 3  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-07 Sp3  trans-acting transcription factor 3  Sp3  Sp3 transcription factor  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2007-04-12 Sp3  Sp3 transcription factor  Sp3_mapped  Sp3 transcription factor (mapped)  Data merged from RGD:3740 737654 APPROVED
2006-11-19 Sp3  Sp3 transcription factor      Symbol and Name status set to provisional 70820 PROVISIONAL
2006-11-19 Sp3_mapped  Sp3 transcription factor(mapped)  Sp3  Sp3 transcription factor  Symbol set to symbol_mapped, name set to name (mapped) 1582166 APPROVED
2003-04-09 Sp3  Sp3 transcription factor    Trans-acting transcription factor 3  Name updated 629478 APPROVED
2002-06-10 Sp3  Trans-acting transcription factor 3      Symbol and Name status set to approved 70586 APPROVED