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Gene: Rufy3 (RUN and FYVE domain containing 3) Rattus norvegicus

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Symbol:

Rufy3

Name:

RUN and FYVE domain containing 3

RGD ID:

1565242

Description:

Predicted to enable dynactin binding activity. Involved in negative regulation of axonogenesis. Located in several cellular components, including growth cone; lamellipodium; and perikaryon. Orthologous to human RUFY3 (RUN and FYVE domain containing 3); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 3,3',4,4',5-pentachlorobiphenyl; 3-chloropropane-1,2-diol.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

rap2 interacting protein x; rap2-interacting protein x; Ripx; RUN and FYVE domain-containing protein 3; singar; Singar1; singar2; single axon-regulated protein

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	RUFY3 (RUN and FYVE domain containing 3)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB
Mus musculus (house mouse):	Rufy3 (RUN and FYVE domain containing 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Rufy3 (RUN and FYVE domain containing 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	RUFY3 (RUN and FYVE domain containing 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	RUFY3 (RUN and FYVE domain containing 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Rufy3 (RUN and FYVE domain containing 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	RUFY3 (RUN and FYVE domain containing 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	RUFY3 (RUN and FYVE domain containing 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Rufy3 (RUN and FYVE domain containing 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus rattus (black rat):	Rufy3 (RUN and FYVE domain containing 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	RUFY3 (RUN and FYVE domain containing 3)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Rufy3 (RUN and FYVE domain containing 3)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	rufy3 (RUN and FYVE domain containing 3)	Alliance	DIOPT (Ensembl Compara\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	rufy3 (RUN and FYVE domain containing 3)	Alliance	DIOPT (Ensembl Compara\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	CG31064	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER)
Drosophila melanogaster (fruit fly):	CG31064	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|OrthoFinder\|OrthoInspector\|PANTHER)
Xenopus tropicalis (tropical clawed frog):	rufy3	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER)
Xenopus tropicalis (tropical clawed frog):	rufy3	Alliance	DIOPT (Ensembl Compara\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	14	19,715,593 - 19,790,530 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	14	19,715,593 - 19,790,608 (-)	Ensembl				GRCr8
mRatBN7.2	14	19,431,530 - 19,506,476 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	14	19,432,524 - 19,507,004 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	14	19,420,898 - 19,495,871 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	14	20,739,762 - 20,814,733 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	14	19,442,194 - 19,517,510 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	14	21,058,575 - 21,144,775 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	14	21,058,595 - 21,128,505 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	14	20,968,402 - 21,040,629 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	14	21,022,765 - 21,070,152 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	14	18,782,702 - 18,829,205 (-)	NCBI		Celera
Cytogenetic Map	14	p22	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Arsenic Poisoning (ISO)

skin disease (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(1->4)-beta-D-glucan (ISO)

1,2-dichloroethane (ISO)

17beta-estradiol (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2-methylcholine (ISO)

3,3',4,4',5-pentachlorobiphenyl (EXP)

3,4-methylenedioxymethamphetamine (ISO)

3-chloropropane-1,2-diol (EXP)

4,4'-sulfonyldiphenol (ISO)

aflatoxin B1 (ISO)

all-trans-retinoic acid (ISO)

antirheumatic drug (ISO)

aristolochic acid A (ISO)

arsane (ISO)

arsenic atom (ISO)

benzo[a]pyrene (ISO)

bisphenol A (EXP,ISO)

Brodifacoum (EXP)

butanal (ISO)

cadmium atom (ISO)

cadmium dichloride (EXP,ISO)

chlorpyrifos (ISO)

copper atom (ISO)

copper(0) (ISO)

cyclosporin A (ISO)

dibenz[a,h]anthracene (ISO)

Dibutyl phosphate (ISO)

diethylstilbestrol (ISO)

dorsomorphin (ISO)

doxorubicin (ISO)

elemental selenium (ISO)

formaldehyde (ISO)

FR900359 (ISO)

gentamycin (EXP)

methylmercury chloride (ISO)

paracetamol (EXP,ISO)

pentanal (ISO)

perfluorononanoic acid (ISO)

perfluorooctane-1-sulfonic acid (ISO)

phenobarbital (ISO)

pregnenolone 16alpha-carbonitrile (ISO)

propiconazole (ISO)

resveratrol (ISO)

SB 431542 (ISO)

selenium atom (ISO)

sodium arsenite (ISO)

succimer (ISO)

sunitinib (ISO)

temozolomide (ISO)

testosterone enanthate (ISO)

tetrachloromethane (ISO)

titanium dioxide (ISO)

trichostatin A (ISO)

triphenyl phosphate (ISO)

triptonide (ISO)

valproic acid (ISO)

vitamin E (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

actin filament organization (ISO,ISS)

cell differentiation (IEA)

negative regulation of axonogenesis (IDA)

nervous system development (IEA)

positive regulation of axon extension (ISO,ISS)

positive regulation of axonogenesis (ISO)

positive regulation of cell migration (IEA,ISO,ISS)

positive regulation of intracellular protein transport (ISO,ISS)

positive regulation of retrograde axon cargo transport (IEA,ISO,ISS)

regulation of axonogenesis (IBA,ISO)

regulation of establishment of cell polarity (ISO,ISS)

Cellular Component

axon (IBA,ISS)

cell projection (IEA)

cytoplasm (IBA,IEA,ISO,ISS)

cytosol (IEA,ISO)

dendrite (IBA,IDA,ISS)

endolysosome (IEA,ISO,ISS)

endomembrane system (IEA)

filopodium (IDA,IEA)

growth cone (IDA,IEA,ISO)

lamellipodium (IDA,IEA)

lysosome (IEA)

neuronal cell body (IBA)

perikaryon (IDA,IEA,ISO)

Molecular Function

dynactin binding (IEA,ISO,ISS)

metal ion binding (IEA)

protein binding (ISO)

zinc ion binding (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Singar1, a novel RUN domain-containing protein, suppresses formation of surplus axons for neuronal polarity.	Mori T, etal., J Biol Chem. 2007 Jul 6;282(27):19884-93. Epub 2007 Apr 17.
3.	GOA pipeline	RGD automated data pipeline
4.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
5.	Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.	Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.

Additional References at PubMed

PMID:15489334	PMID:22871113	PMID:23206279	PMID:23904609	PMID:24720729	PMID:25766321

Genomics

Comparative Map Data

Rufy3
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	14	19,715,593 - 19,790,530 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	14	19,715,593 - 19,790,608 (-)	Ensembl				GRCr8
mRatBN7.2	14	19,431,530 - 19,506,476 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	14	19,432,524 - 19,507,004 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	14	19,420,898 - 19,495,871 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	14	20,739,762 - 20,814,733 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	14	19,442,194 - 19,517,510 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	14	21,058,575 - 21,144,775 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	14	21,058,595 - 21,128,505 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	14	20,968,402 - 21,040,629 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	14	21,022,765 - 21,070,152 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	14	18,782,702 - 18,829,205 (-)	NCBI		Celera
Cytogenetic Map	14	p22	NCBI

RUFY3
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	4	70,703,767 - 70,808,619 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	4	70,704,204 - 70,808,619 (+)	Ensembl			hg38	GRCh38
GRCh37	4	71,570,456 - 71,674,336 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	4	71,806,560 - 71,891,789 (+)	NCBI	Build 36	Build 36	hg18	NCBI36
Celera	4	68,927,653 - 69,031,337 (+)	NCBI		Celera
Cytogenetic Map	4	q13.3	NCBI
HuRef	4	67,374,309 - 67,478,077 (+)	NCBI		HuRef
CHM1_1	4	71,606,608 - 71,710,363 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	4	74,046,233 - 74,151,087 (+)	NCBI		T2T-CHM13v2.0

Rufy3
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	5	88,711,305 - 88,799,276 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	5	88,712,899 - 88,799,251 (+)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	5	88,564,505 - 88,651,417 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	5	88,565,040 - 88,651,392 (+)	Ensembl			mm10	GRCm38
MGSCv37	5	89,012,599 - 89,071,721 (+)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	5	89,658,135 - 89,717,257 (+)	NCBI		MGSCv36	mm8
Celera	5	86,733,200 - 86,791,895 (+)	NCBI		Celera
Cytogenetic Map	5	E1	NCBI
cM Map	5	43.77	NCBI

Rufy3
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955447	2,211,262 - 2,266,008 (-)	Ensembl
ChiLan1.0	NW_004955447	2,200,788 - 2,266,008 (-)	NCBI	ChiLan1.0	ChiLan1.0

RUFY3
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	3	59,276,447 - 59,377,256 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	4	59,471,389 - 59,572,248 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	4	53,415,742 - 53,516,600 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	4	59,762,339 - 59,846,574 (-)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	4	59,762,053 - 59,846,574 (-)	Ensembl			panPan2	panpan1.1

RUFY3
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	13	60,007,041 - 60,079,198 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	13	60,007,056 - 60,078,617 (+)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	13	59,741,413 - 59,813,528 (+)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	13	60,813,185 - 60,885,065 (+)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	13	60,812,369 - 60,885,059 (+)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	13	60,427,868 - 60,499,800 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	13	59,919,548 - 59,991,670 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	13	61,067,046 - 61,138,949 (+)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Rufy3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405285	15,535,254 - 15,594,049 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936598	3,987,320 - 4,046,187 (-)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936598	3,987,287 - 4,046,019 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

RUFY3
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	8	67,495,033 - 67,582,142 (+)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	8	67,494,552 - 67,582,144 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	8	71,403,191 - 71,490,372 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

RUFY3
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	7	19,214,051 - 19,316,840 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	7	19,232,434 - 19,300,550 (+)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666084	3,562,094 - 3,671,841 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Rufy3
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624890	2,032,995 - 2,134,648 (+)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624890	2,032,980 - 2,135,922 (+)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Rufy3
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	11	2,055,531 - 2,139,481 (+)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Rufy3
924 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	116
Count of miRNA genes:	88
Interacting mature miRNAs:	89
Transcripts:	ENSRNOT00000004776, ENSRNOT00000020608
Prediction methods:	Microtar, Miranda, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1300114	Srn2	Serum renin concentration QTL 2	3.27		blood renin amount (VT:0003349)	plasma renin activity level (CMO:0000116)	14	3957878	21572472	Rat
631528	Scl11	Serum cholesterol level QTL 11	4.9		blood cholesterol amount (VT:0000180)	blood total cholesterol level (CMO:0000051)	14	17875645	36079022	Rat
7411573	Bw139	Body weight QTL 139	4.7	0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	14	1	40068101	Rat
9589814	Gluco67	Glucose level QTL 67	4.54	0.001	blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	14	1	40068101	Rat
731183	Pia20	Pristane induced arthritis QTL 20	3.55		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	14	9393298	39411170	Rat
631212	Bw5	Body weight QTL5	5.43		retroperitoneal fat pad mass (VT:0010430)	retroperitoneal fat pad weight to body weight ratio (CMO:0000635)	14	11334906	30674469	Rat
2302277	Gluco38	Glucose level QTL 38	5.8		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	14	11334716	28389666	Rat
1331740	Bw26	Body weight QTL 26	3.028		body mass (VT:0001259)	body weight (CMO:0000012)	14	3957878	31121464	Rat
1358296	Ael3	Aortic elastin QTL 3	3.7	0.00051	aorta elastin amount (VT:0003905)	aortic elastin	14	8621398	53621398	Rat
61420	Pia6	Pristane induced arthritis QTL 6	4.9		joint integrity trait (VT:0010548)	arthritic paw count (CMO:0001460)	14	18915454	42433608	Rat
70195	Mcs8	Mammary carcinoma susceptibility QTL 8	4.28		mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	14	3957878	24886169	Rat
631839	Niddm37	Non-insulin dependent diabetes mellitus QTL 37	3.37		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	14	11334716	100078267	Rat
2313397	Coatc1	Coat color QTL1			coat/hair pigmentation trait (VT:0010463)	coat/hair color measurement (CMO:0001808)	14	18895192	63895192	Rat
631262	Tcas4	Tongue tumor susceptibility QTL 4	7.29		tongue integrity trait (VT:0010553)	number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)	14	17906726	54251504	Rat
634352	Apr6	Acute phase response QTL 6	3.7		blood interleukin-6 amount (VT:0008595)	plasma interleukin-6 level (CMO:0001927)	14	1	41415516	Rat
70204	Niddm20	Non-insulin dependent diabetes mellitus QTL 20	5.1	0.000008	blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	14	1	31893212	Rat
2302045	Pia39	Pristane induced arthritis QTL 39	4.9	0.001	blood immunoglobulin amount (VT:0002460)	serum immunoglobulin G2a level (CMO:0002116)	14	8621398	53621398	Rat
1300140	Srn3	Serum renin concentration QTL 3	3.19		blood renin amount (VT:0003349)	plasma renin activity level (CMO:0000116)	14	15137594	31238250	Rat

Markers in Region

RH131654

Rat Assembly	Chr	Position (strand)	Source	JBrowse
GRCr8	14	19,715,970 - 19,716,173 (+)	Marker Load Pipeline
mRatBN7.2	14	19,431,907 - 19,432,110 (+)	MAPPER	mRatBN7.2
Rnor_6.0	14	21,058,953 - 21,059,155	NCBI	Rnor6.0
Rnor_5.0	14	20,968,780 - 20,968,982	UniSTS	Rnor5.0
RGSC_v3.4	14	21,011,126 - 21,011,328	UniSTS	RGSC3.4
Celera	14	18,771,078 - 18,771,280	UniSTS
RH 3.4 Map	14	285.4	UniSTS
Cytogenetic Map	14	p22	UniSTS

RH132885

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	14	19,441,212 - 19,441,424 (+)	MAPPER	mRatBN7.2
Rnor_6.0	14	21,068,258 - 21,068,469	NCBI	Rnor6.0
Rnor_5.0	14	20,978,085 - 20,978,296	UniSTS	Rnor5.0
RGSC_v3.4	14	21,020,431 - 21,020,642	UniSTS	RGSC3.4
Celera	14	18,780,368 - 18,780,579	UniSTS
RH 3.4 Map	14	292.4	UniSTS
Cytogenetic Map	14	p22	UniSTS

RH134531

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	14	19,441,569 - 19,441,752 (+)	MAPPER	mRatBN7.2
Rnor_6.0	14	21,068,615 - 21,068,797	NCBI	Rnor6.0
Rnor_5.0	14	20,978,442 - 20,978,624	UniSTS	Rnor5.0
RGSC_v3.4	14	21,020,788 - 21,020,970	UniSTS	RGSC3.4
Celera	14	18,780,725 - 18,780,907	UniSTS
RH 3.4 Map	14	289.9	UniSTS
Cytogenetic Map	14	p22	UniSTS

BG376722

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	14	19,432,743 - 19,432,885 (+)	MAPPER	mRatBN7.2
Rnor_6.0	14	21,059,789 - 21,059,930	NCBI	Rnor6.0
Rnor_5.0	14	20,969,616 - 20,969,757	UniSTS	Rnor5.0
RGSC_v3.4	14	21,011,962 - 21,012,103	UniSTS	RGSC3.4
Celera	14	18,771,914 - 18,772,055	UniSTS
RH 3.4 Map	14	285.4	UniSTS
Cytogenetic Map	14	p22	UniSTS

BI295036

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	14	19,488,641 - 19,488,777 (+)	MAPPER	mRatBN7.2
Rnor_6.0	14	21,126,671 - 21,126,806	NCBI	Rnor6.0
Rnor_5.0	14	21,036,498 - 21,036,633	UniSTS	Rnor5.0
RGSC_v3.4	14	21,068,318 - 21,068,453	UniSTS	RGSC3.4
Celera	14	18,827,375 - 18,827,510	UniSTS
RH 3.4 Map	14	293.6	UniSTS
Cytogenetic Map	14	p22	UniSTS

AW529895

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	14	19,435,598 - 19,435,803 (+)	MAPPER	mRatBN7.2
Rnor_6.0	14	21,062,644 - 21,062,848	NCBI	Rnor6.0
Rnor_5.0	14	20,972,471 - 20,972,675	UniSTS	Rnor5.0
RGSC_v3.4	14	21,014,817 - 21,015,021	UniSTS	RGSC3.4
Celera	14	18,774,754 - 18,774,958	UniSTS
RH 3.4 Map	14	285.3	UniSTS
Cytogenetic Map	14	p22	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
16	12	67	164	91	90	59	92	59	6	356	192	11	143	81	92	31	17	17

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001025127	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_001401613	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_001401614	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_001401615	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006250784	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	BC089952	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH474060	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	EF538802	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	EF577045	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000014	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000004776 ⟹ ENSRNOP00000004776

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	14	19,715,593 - 19,774,557 (-)	Ensembl
mRatBN7.2 Ensembl	14	19,432,524 - 19,490,474 (-)	Ensembl
Rnor_6.0 Ensembl	14	21,070,593 - 21,128,505 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000020608 ⟹ ENSRNOP00000020608

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	14	19,715,593 - 19,774,557 (-)	Ensembl
mRatBN7.2 Ensembl	14	19,432,524 - 19,489,839 (-)	Ensembl
Rnor_6.0 Ensembl	14	21,070,610 - 21,127,868 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000092172 ⟹ ENSRNOP00000073742

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	14	19,715,593 - 19,773,898 (-)	Ensembl
mRatBN7.2 Ensembl	14	19,432,524 - 19,489,839 (-)	Ensembl
Rnor_6.0 Ensembl	14	21,058,595 - 21,127,875 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000100042 ⟹ ENSRNOP00000093326

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	14	19,725,556 - 19,790,530 (-)	Ensembl
mRatBN7.2 Ensembl	14	19,443,548 - 19,507,004 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000103075 ⟹ ENSRNOP00000096851

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	14	19,715,593 - 19,790,608 (-)	Ensembl
mRatBN7.2 Ensembl	14	19,432,524 - 19,507,004 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000109188 ⟹ ENSRNOP00000078674

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	14	19,715,593 - 19,763,805 (-)	Ensembl
mRatBN7.2 Ensembl	14	19,432,524 - 19,479,766 (-)	Ensembl

RefSeq Acc Id:

NM_001025127 ⟹ NP_001020298

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	14	19,725,556 - 19,774,557 (-)	NCBI
mRatBN7.2	14	19,441,493 - 19,490,498 (-)	NCBI
Rnor_6.0	14	21,070,592 - 21,128,505 (-)	NCBI
Rnor_5.0	14	20,968,402 - 21,040,629 (-)	NCBI
RGSC_v3.4	14	21,022,765 - 21,070,152 (-)	RGD
Celera	14	18,782,702 - 18,829,205 (-)	RGD

Sequence:

show sequence

CCTGGATTTTCAGTTCAGTTCATTAGTCAGCCATTTTGGTCAACACCCTGCTTACTGCGCACAA
CCAATCCTGTTAGAACTCAGCATCCCGGCTCATCTGAGCAGATCCTCTAGTGATTTCTGCTGGT
CAAAATTTTTTAAGATAAATTGAAACTATAGCTTAATTTTTTTTATTTATATTTTTTCTTTTTG
TATTTTTTTCTGCACAAAGAAGGCGGATTTTTTTTTTCACTTATTCATGCCAAGACCAATTTTT
GAAAGCCAGCATTGGGTGTGTAGGATTTAAGCCTATAGATAGCCTTGTTGGAATAAAGGAAAAG
GAAGATCAAAGGAGAGCACGCTGGTGGAGGACGGCGCCGGCTAACCTTGCTAACCATTAGGAAT
TGCTATTAAGAAAAGAGAGATACAATTGTTTGTTTTGAGCAGTTTGTTCTATAAGCTGACTCAT
CATGTCTGCCCTGACGCCTCCGACTGATATGCCAACCCCCACCACTGACAAGATAACCCAGGCT
GCCATGGAGACCATCTACCTCTGCAAATTCCGGGTGTCTATGGATGGAGAATGGCTCTGCCTTC
GAGAGCTGGATGACATCTCCCTTACACCTGACCCAGAGCCTACCCATGAAGATCCTAATTATCT
CATGGCTAACGAGCGCATGAACCTGATGAACATGGCGAAGCTGAGCATCAAGGGCTTGATTGAG
TCGGCTCTGAACCTGGGGCGGACCCTGGACTCTGACTACGCACCTCTCCAGCAGTTCTTCGTGG
TGATGGAACACTGCCTGAAACATGGCTTGAAAGCCAAGAAAACTTTTCTTGGACAAAATAAGTC
CTTCTGGGGTCCTCTAGAGCTGGTAGAAAAGCTTGTTCCAGAAGCTGCAGAGATAACAGCAAGT
GTAAAAGATCTCCCAGGACTCAAGACACCAGTTGGCAGAGGAAGAGCCTGGCTTCGGTTGGCAT
TAATGCAAAAGAAGCTTTCTGAGTACATGAAGGCCTTGATCAATAAGAAGGAACTTCTCAGTGA
GTTCTATGAAGCCAATGCTCTCATGATGGAAGAAGAAGGCGCAATTATTGCTGGCCTCCTGGTC
GGTCTGAATGTCATCGATGCCAATTTCTGCATGAAAGGAGAAGACCTGGACTCTCAGGTTGGCG
TTATAGACTTTTCAATGTATCTCAAAGATGGGAACAGCAGTAAAGGCAGTGAAGGGGATGGACA
GATTACTGCGATTCTGGACCAGAAAAACTATGTAGAAGAACTCAACAGACATCTGAATGCTACT
GTAAACAACCTTCAGGCAAAAGTAGATGCGTTAGAAAAATCCAACACGAAATTGACAGAGGAAC
TTGCCGTCGCCAACAACAGAATTATTACCTTACAAGAAGAAATGGAACGGGTTAAAGAAGAAAG
TTCCTATCTACTGGAATCCAATCGGAAGGGTCCTAAGCAAGACAGAACTGCAGAAGGGCAAGCG
CTGAGCGAAGCCAGAAAGCATCTAAAGGAGGAGACACAGTTACGATTGGACGTTGAAAAGGAGC
TGGAGCTGCAGATCAGCATGAGGCAGGAGATGGAACTGGCTATGAAGATGCTGGAGAAGGATGT
CTGTGAGAAGCAGGATGCCCTGGTGTCCCTGCGGCAGCAGCTGGATGATCTCCGAGCTCTTAAA
CACGAGCTTGCCTTTAAGCTGCAGAGTTCAGACCTAGGAGTGAAACAGAAAAGTGAATTAAACA
GTCGCTTGGAAGAGAAGACCAATCAGATGGCTGCCACCATTAAACAGCTGGAGCAAAGTGAAAA
AGATTTGGTGAAACAGGCAAAGACCTTAAATAGTGCAGCAAATAAACTGATCCCAAAACATCAT
TAAACGTTTTGCAGTTGGTCAAAAAAAAAAAAAAAAAAAAAAAAAAA

hide sequence

RefSeq Acc Id:

NM_001401613 ⟹ NP_001388542

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	14	19,715,593 - 19,790,530 (-)	NCBI
mRatBN7.2	14	19,431,530 - 19,506,476 (-)	NCBI

RefSeq Acc Id:

NM_001401614 ⟹ NP_001388543

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	14	19,725,556 - 19,790,530 (-)	NCBI
mRatBN7.2	14	19,441,493 - 19,506,476 (-)	NCBI

RefSeq Acc Id:

NM_001401615 ⟹ NP_001388544

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	14	19,725,556 - 19,774,557 (-)	NCBI
mRatBN7.2	14	19,441,493 - 19,490,498 (-)	NCBI

Protein Sequences


Protein RefSeqs	NP_001020298	(Get FASTA)	NCBI Sequence Viewer
	NP_001388542	(Get FASTA)	NCBI Sequence Viewer
	NP_001388543	(Get FASTA)	NCBI Sequence Viewer
	NP_001388544	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH89952	(Get FASTA)	NCBI Sequence Viewer
	ABP99060	(Get FASTA)	NCBI Sequence Viewer
	ABQ45403	(Get FASTA)	NCBI Sequence Viewer
	EDL88518	(Get FASTA)	NCBI Sequence Viewer
	EDL88519	(Get FASTA)	NCBI Sequence Viewer
	EDL88520	(Get FASTA)	NCBI Sequence Viewer
	EDL88521	(Get FASTA)	NCBI Sequence Viewer
	EDL88522	(Get FASTA)	NCBI Sequence Viewer
	EDL88523	(Get FASTA)	NCBI Sequence Viewer
	EDL88524	(Get FASTA)	NCBI Sequence Viewer
	EDL88525	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000093326
	ENSRNOP00000096851
GenBank Protein	Q5FVJ0	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:	NP_001020298 ⟸ NM_001025127
- Peptide Label:	isoform 4
- UniProtKB:	A5HLX7 (UniProtKB/Swiss-Prot), A5JUR6 (UniProtKB/Swiss-Prot), Q5FVJ0 (UniProtKB/Swiss-Prot)
- Sequence:	show sequence MSALTPPTDMPTPTTDKITQAAMETIYLCKFRVSMDGEWLCLRELDDISLTPDPEPTHEDPNYL MANERMNLMNMAKLSIKGLIESALNLGRTLDSDYAPLQQFFVVMEHCLKHGLKAKKTFLGQNKS FWGPLELVEKLVPEAAEITASVKDLPGLKTPVGRGRAWLRLALMQKKLSEYMKALINKKELLSE FYEANALMMEEEGAIIAGLLVGLNVIDANFCMKGEDLDSQVGVIDFSMYLKDGNSSKGSEGDGQ ITAILDQKNYVEELNRHLNATVNNLQAKVDALEKSNTKLTEELAVANNRIITLQEEMERVKEES SYLLESNRKGPKQDRTAEGQALSEARKHLKEETQLRLDVEKELELQISMRQEMELAMKMLEKDV CEKQDALVSLRQQLDDLRALKHELAFKLQSSDLGVKQKSELNSRLEEKTNQMAATIKQLEQSEK DLVKQAKTLNSAANKLIPKHH hide sequence

Ensembl Acc Id:

ENSRNOP00000073742 ⟸ ENSRNOT00000092172

Ensembl Acc Id:

ENSRNOP00000004776 ⟸ ENSRNOT00000004776

Ensembl Acc Id:

ENSRNOP00000020608 ⟸ ENSRNOT00000020608

Ensembl Acc Id:

ENSRNOP00000093326 ⟸ ENSRNOT00000100042

Ensembl Acc Id:

ENSRNOP00000078674 ⟸ ENSRNOT00000109188

Ensembl Acc Id:

ENSRNOP00000096851 ⟸ ENSRNOT00000103075

RefSeq Acc Id:	NP_001388542 ⟸ NM_001401613
- Peptide Label:	isoform 1
- UniProtKB:	A0A8I5ZLF4 (UniProtKB/TrEMBL), A0A8I6ARF6 (UniProtKB/TrEMBL)

RefSeq Acc Id:	NP_001388543 ⟸ NM_001401614
- Peptide Label:	isoform 2
- UniProtKB:	A0A8I6AK59 (UniProtKB/TrEMBL)

RefSeq Acc Id:	NP_001388544 ⟸ NM_001401615
- Peptide Label:	isoform 3

Protein Domains

RUN

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q5FVJ0-F1-model_v2	AlphaFold	Q5FVJ0	1-469	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13699241

Promoter ID:

EPDNEW_R9766

Type:

initiation region

Name:

Rufy3_1

Description:

RUN and FYVE domain containing 3

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	14	21,128,467 - 21,128,527	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1565242	AgrOrtholog
BioCyc Gene	G2FUF-16165	BioCyc
Ensembl Genes	ENSRNOG00000003428	Ensembl, ENTREZGENE
Ensembl Transcript	ENSRNOT00000100042	ENTREZGENE
	ENSRNOT00000103075	ENTREZGENE
Gene3D-CATH	1.20.5.170	UniProtKB/Swiss-Prot
	1.20.58.900	UniProtKB/Swiss-Prot
IMAGE_CLONE	IMAGE:7312240	IMAGE-MGC_LOAD
InterPro	RUFY1-3	UniProtKB/Swiss-Prot
	Run_dom	UniProtKB/Swiss-Prot
	Run_dom_sf	UniProtKB/Swiss-Prot
	RUN_RUFY3	UniProtKB/Swiss-Prot
KEGG Report	rno:360921	UniProtKB/Swiss-Prot
MGC_CLONE	MGC:109279	IMAGE-MGC_LOAD
NCBI Gene	360921	ENTREZGENE
PANTHER	PROTEIN RUFY3	UniProtKB/Swiss-Prot
	RUN AND FYVE DOMAIN-CONTAINING PROTEIN 2-LIKE PROTEIN	UniProtKB/Swiss-Prot
Pfam	RUN	UniProtKB/Swiss-Prot
PhenoGen	Rufy3	PhenoGen
PROSITE	RUN	UniProtKB/Swiss-Prot
RatGTEx	ENSRNOG00000003428	RatGTEx
SMART	RUN	UniProtKB/Swiss-Prot
Superfamily-SCOP	SSF140741	UniProtKB/Swiss-Prot
UniProt	A0A0G2K6A9_RAT	UniProtKB/TrEMBL
	A0A8I5ZLF4	ENTREZGENE, UniProtKB/TrEMBL
	A0A8I6AK59	ENTREZGENE, UniProtKB/TrEMBL
	A0A8I6ARF6	ENTREZGENE, UniProtKB/TrEMBL
	A0A8L2Q1K8_RAT	UniProtKB/TrEMBL
	A0A8L2QAC6_RAT	UniProtKB/TrEMBL
	A5HLX7	ENTREZGENE
	A5JUR6	ENTREZGENE
	Q5FVJ0	ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary	A5HLX7	UniProtKB/Swiss-Prot
	A5JUR6	UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2008-03-07	Rufy3	RUN and FYVE domain containing 3	Ripx	rap2 interacting protein x	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2006-02-09	Ripx	rap2 interacting protein x			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - CTD