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Gene: Rnf216 (ring finger protein 216) Rattus norvegicus

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Symbol:

Rnf216

Name:

ring finger protein 216

RGD ID:

1565135

Description:

Predicted to enable ubiquitin protein ligase activity. Involved in protein catabolic process, modulating synaptic transmission and regulation of postsynaptic neurotransmitter receptor internalization. Is active in several cellular components, including Schaffer collateral - CA1 synapse; glutamatergic synapse; and postsynaptic endocytic zone. Human ortholog(s) of this gene implicated in Gordon Holmes syndrome. Orthologous to human RNF216 (ring finger protein 216); INTERACTS WITH acrylamide; bisphenol A; cadmium atom.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

E3 ubiquitin-protein ligase RNF216; LOC304294; RGD1565135; similar to E3 ubiquitin ligase TRIAD3B

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	RNF216 (ring finger protein 216)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, Treefam
Mus musculus (house mouse):	Rnf216 (ring finger protein 216)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Rnf216 (ring finger protein 216)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	RNF216 (ring finger protein 216)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	RNF216 (ring finger protein 216)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Rnf216 (ring finger protein 216)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	RNF216 (ring finger protein 216)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	RNF216 (ring finger protein 216)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Rnf216 (ring finger protein 216)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus rattus (black rat):	Rnf216 (ring finger protein 216)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	FAM222A (family with sequence similarity 222 member A)	HGNC	OMA
Alliance orthologs ³
Mus musculus (house mouse):	Rnf216 (ring finger protein 216)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Homo sapiens (human):	RNF216 (ring finger protein 216)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	rnf216 (ring finger protein 216)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	Y57A10A.31	Alliance	DIOPT (Ensembl Compara\|PANTHER)
Xenopus tropicalis (tropical clawed frog):	rnf216	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	rnf216	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoFinder\|PANTHER)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	12	16,568,327 - 16,689,868 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	12	16,568,347 - 16,690,989 (+)	Ensembl				GRCr8
mRatBN7.2	12	11,454,752 - 11,576,305 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	12	11,454,797 - 11,576,304 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	12	12,263,009 - 12,386,275 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	12	12,886,286 - 13,009,554 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	12	11,912,387 - 12,035,725 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	12	13,508,429 - 13,631,689 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	12	13,508,429 - 13,632,304 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	12	15,547,724 - 15,668,304 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	12	11,850,549 - 11,968,127 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	12	13,249,412 - 13,370,214 (+)	NCBI		Celera
Cytogenetic Map	12	p11	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

genetic disease (ISO)

Gordon Holmes syndrome (ISO)

hypogonadotropic hypogonadism 7 with or without anosmia (ISO)

rosette-forming glioneuronal tumor (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(-)-epigallocatechin 3-gallate (ISO)

(1->4)-beta-D-glucan (ISO)

1,2-dimethylhydrazine (ISO)

2,3',4,4',5-Pentachlorobiphenyl (ISO)

2,3,7,8-tetrachlorodibenzodioxine (ISO)

4,4'-sulfonyldiphenol (ISO)

acrylamide (EXP)

arsane (ISO)

arsenic atom (ISO)

atrazine (ISO)

benzo[a]pyrene (ISO)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (EXP,ISO)

butanal (ISO)

Butylbenzyl phthalate (ISO)

cadmium atom (EXP,ISO)

cadmium dichloride (EXP,ISO)

CGP 52608 (ISO)

chromium(6+) (ISO)

cyclophosphamide (EXP)

dioxygen (ISO)

doxorubicin (ISO)

fipronil (EXP)

fulvestrant (ISO)

GSK-J4 (ISO)

levonorgestrel (ISO)

perfluorohexanesulfonic acid (ISO)

perfluorooctane-1-sulfonic acid (ISO)

pinostrobin (ISO)

pirinixic acid (ISO)

potassium chromate (ISO)

silver atom (ISO)

silver(0) (ISO)

sodium arsenite (ISO)

sunitinib (ISO)

temozolomide (ISO)

testosterone undecanoate (ISO)

titanium dioxide (ISO)

triphenyl phosphate (ISO)

troglitazone (ISO)

tungsten (ISO)

vinclozolin (ISO)

zinc atom (ISO)

zinc(0) (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

proteasome-mediated ubiquitin-dependent protein catabolic process (ISO)

protein catabolic process, modulating synaptic transmission (IDA,IMP)

protein K48-linked ubiquitination (ISO)

regulation of defense response to virus by host (ISO)

regulation of interferon-beta production (ISO)

regulation of postsynaptic neurotransmitter receptor internalization (IDA,IMP)

Cellular Component

cytosol (ISO)

glutamatergic synapse (IDA,IMP)

nucleus (ISO)

postsynaptic endocytic zone (IDA)

presynapse (IDA)

Schaffer collateral - CA1 synapse (IDA)

Molecular Function

metal ion binding (IEA)

protein binding (ISO)

transferase activity (IEA)

ubiquitin protein ligase activity (ISO)

zinc ion binding (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Triad3A regulates synaptic strength by ubiquitination of Arc.	Mabb AM, etal., Neuron. 2014 Jun 18;82(6):1299-316. doi: 10.1016/j.neuron.2014.05.016.
2.	OMIM Disease Annotation Pipeline	OMIM Disease Annotation Pipeline
3.	GOA pipeline	RGD automated data pipeline
4.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:19893624	PMID:32918771

Genomics

Comparative Map Data

Rnf216
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	12	16,568,327 - 16,689,868 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	12	16,568,347 - 16,690,989 (+)	Ensembl				GRCr8
mRatBN7.2	12	11,454,752 - 11,576,305 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	12	11,454,797 - 11,576,304 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	12	12,263,009 - 12,386,275 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	12	12,886,286 - 13,009,554 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	12	11,912,387 - 12,035,725 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	12	13,508,429 - 13,631,689 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	12	13,508,429 - 13,632,304 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	12	15,547,724 - 15,668,304 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	12	11,850,549 - 11,968,127 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	12	13,249,412 - 13,370,214 (+)	NCBI		Celera
Cytogenetic Map	12	p11	NCBI

RNF216
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	7	5,620,047 - 5,781,663 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	7	5,620,047 - 5,781,696 (-)	Ensembl			hg38	GRCh38
GRCh37	7	5,659,678 - 5,821,294 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	7	5,626,204 - 5,787,818 (-)	NCBI	Build 36	Build 36	hg18	NCBI36
Celera	7	5,619,295 - 5,780,893 (-)	NCBI		Celera
Cytogenetic Map	7	p22.1	NCBI
HuRef	7	5,571,731 - 5,733,450 (-)	NCBI		HuRef
CHM1_1	7	5,659,283 - 5,820,961 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	7	5,737,579 - 5,899,098 (-)	NCBI		T2T-CHM13v2.0
CRA_TCAGchr7v2	7	5,706,017 - 5,867,706 (-)	NCBI

Rnf216
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	5	142,976,648 - 143,098,793 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	5	142,976,648 - 143,098,749 (-)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	5	142,990,893 - 143,113,041 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	5	142,990,893 - 143,112,994 (-)	Ensembl			mm10	GRCm38
MGSCv37	5	143,752,572 - 143,874,673 (-)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	5	143,256,033 - 143,378,134 (-)	NCBI		MGSCv36	mm8
Celera	5	140,039,423 - 140,158,416 (-)	NCBI		Celera
Cytogenetic Map	5	G2	NCBI
cM Map	5	81.86	NCBI

Rnf216
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955460	10,425,885 - 10,551,295 (-)	Ensembl
ChiLan1.0	NW_004955460	10,423,736 - 10,578,421 (-)	NCBI	ChiLan1.0	ChiLan1.0

RNF216
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	6	10,579,755 - 10,746,674 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	7	58,904,460 - 59,071,382 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	7	5,872,118 - 6,037,073 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	7	5,891,909 - 6,051,979 (-)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	7	5,891,909 - 6,051,979 (-)	Ensembl			panPan2	panpan1.1

RNF216
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	6	12,185,870 - 12,347,461 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	6	12,185,846 - 12,361,869 (+)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	6	13,690,975 - 13,819,412 (+)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	6	12,279,451 - 12,440,387 (+)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	6	12,279,466 - 12,483,247 (+)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	6	12,133,461 - 12,294,697 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	6	12,067,337 - 12,228,144 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	6	12,343,974 - 12,505,522 (+)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Rnf216
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024409344	140,441,068 - 140,601,298 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936765	473,025 - 589,681 (+)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936765	452,755 - 592,358 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

RNF216
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	3	4,158,450 - 4,329,378 (-)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	3	4,158,447 - 4,329,458 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	3	4,800,772 - 4,820,346 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

RNF216
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	28	15,955,499 - 16,114,307 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	28	15,954,803 - 16,117,759 (+)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666090	5,879,677 - 6,041,644 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Rnf216
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624740	27,885,778 - 28,024,710 (+)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624740	27,861,094 - 28,024,619 (+)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Rnf216
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	16	10,031,196 - 10,153,781 (+)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Rnf216
1082 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	287
Count of miRNA genes:	169
Interacting mature miRNAs:	205
Transcripts:	ENSRNOT00000001458
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
2312418	Kidm41	Kidney mass QTL 41	3.7	0.0001	kidney mass (VT:0002707)	single kidney wet weight to body weight ratio (CMO:0000622)	12	5921918	25247790	Rat
70213	Niddm27	Non-insulin dependent diabetes mellitus QTL 27	3.72		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	12	11200494	52308831	Rat
2306789	Ean6	Experimental allergic neuritis QTL 6	4.9		nervous system integrity trait (VT:0010566)	experimental autoimmune neuritis severity score (CMO:0001528)	12	1	29775522	Rat
8552964	Pigfal17	Plasma insulin-like growth factor 1 level QTL 17	3.5		blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	12	11200494	52308831	Rat
7411641	Foco19	Food consumption QTL 19	27.7	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	12	11200494	52308831	Rat
1357337	Gluco3	Glucose level QTL 3		0.0004	adipocyte glucose uptake trait (VT:0004185)	absolute change in adipocyte glucose uptake (CMO:0000873)	12	1	16966671	Rat
5684888	Pia42	Pristane induced arthritis QTL 42			joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	12	3489416	48489416	Rat
1331739	Hrtrt14	Heart rate QTL 14	3.56232		heart pumping trait (VT:2000009)	heart rate (CMO:0000002)	12	1	38687564	Rat
8552912	Pigfal6	Plasma insulin-like growth factor 1 level QTL 6	5		blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	12	11200497	52308831	Rat
1549829	Scl48	Serum cholesterol level QTL 48	5		blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	12	15264248	52308831	Rat
61331	Eau2	Experimental allergic uveoretinitis QTL 2		0.0005	uvea integrity trait (VT:0010551)	experimental autoimmune uveitis score (CMO:0001504)	12	1	33700600	Rat
10059594	Kidm46	Kidney mass QTL 46	3.79	0.025	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	12	11743528	52308831	Rat
8552918	Pigfal7	Plasma insulin-like growth factor 1 level QTL 7			blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	12	11200494	52308831	Rat
1581516	Cm56	Cardiac mass QTL 56	4.2	0.05	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	12	11869600	16966542	Rat
61334	Gluco17	Glucose level QTL 17	6.3		adipocyte glucose uptake trait (VT:0004185)	adipocyte maximal glucose uptake to basal glucose uptake ratio (CMO:0000874)	12	1	16966671	Rat
2293684	Bmd26	Bone mineral density QTL 26	4.4	0.0002	femur mineral mass (VT:0010011)	total volumetric bone mineral density (CMO:0001728)	12	1	38635130	Rat
6893681	Bw109	Body weight QTL 109	2.3	0.004	body mass (VT:0001259)	body weight (CMO:0000012)	12	1	28133365	Rat
1302792	Scl21	Serum cholesterol level QTL 21	3.8	0.0011	blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	12	12233000	30490641	Rat
1300174	Bw15	Body weight QTL 15	2.93		body mass (VT:0001259)	body weight loss (CMO:0001399)	12	1	28606299	Rat
1331786	Kidm11	Kidney mass QTL 11	3.571		kidney mass (VT:0002707)	right kidney wet weight (CMO:0000082)	12	16187438	52308831	Rat
1331787	Rf41	Renal function QTL 41	2.998		kidney blood vessel physiology trait (VT:0100012)	absolute change in renal blood flow rate (CMO:0001168)	12	1	33700556	Rat
2293699	Bss49	Bone structure and strength QTL 49	5.61	0.0001	lumbar vertebra size trait (VT:0010518)	lumbar vertebra trabecular cross-sectional area (CMO:0001692)	12	16135029	52308831	Rat
1331761	Bp218	Blood pressure QTL 218	2.973		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	12	16187438	51213550	Rat
1331763	Wbc2	White blood cell count QTL 2	3.162		leukocyte quantity (VT:0000217)	total white blood cell count (CMO:0000365)	12	11200494	52308831	Rat
7204484	Bp358	Blood pressure QTL 358		0.001	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	12	1	24849755	Rat
7411547	Bw129	Body weight QTL 129		0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	6	11200494	52308831	Rat
7387292	Kidm42	Kidney mass QTL 42	3.03	0.0004	kidney mass (VT:0002707)	left kidney wet weight (CMO:0000083)	12	1	41361854	Rat
1298081	Cia25	Collagen induced arthritis QTL 25	4.7		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	12	2747694	47747694	Rat
2303568	Bw88	Body weight QTL 88	3		body mass (VT:0001259)	body weight (CMO:0000012)	12	1	28606299	Rat
2303575	Insul14	Insulin level QTL 14	4		blood insulin amount (VT:0001560)	blood insulin level (CMO:0000349)	12	3087180	48087180	Rat
7411588	Foco6	Food consumption QTL 6		0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	12	11200494	52308831	Rat
7243862	Mcs30	Mammary carcinoma susceptibility QTL 30	8.62		mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	12	5633306	50633306	Rat
2300186	Bmd59	Bone mineral density QTL 59	7.1	0.0001	lumbar vertebra mineral mass (VT:0010511)	volumetric bone mineral density (CMO:0001553)	12	16135029	52308831	Rat
2293086	Iddm30	Insulin dependent diabetes mellitus QTL 30	3.82		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	12	7901625	33938215	Rat
7411597	Foco10	Food consumption QTL 10		0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	12	11200494	52308831	Rat
1331755	Bp219	Blood pressure QTL 219	3.041		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	12	16187438	33700556	Rat

Markers in Region

BE117877

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	12	11,504,190 - 11,504,383 (+)	MAPPER	mRatBN7.2
Rnor_6.0	12	13,557,812 - 13,558,004	NCBI	Rnor6.0
Rnor_5.0	12	15,596,773 - 15,596,965	UniSTS	Rnor5.0
RGSC_v3.4	12	11,903,466 - 11,903,658	UniSTS	RGSC3.4
Celera	12	13,298,552 - 13,298,744	UniSTS
RH 3.4 Map	12	154.3	UniSTS
Cytogenetic Map	12	p11	UniSTS

RH128286

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	12	11,575,887 - 11,576,068 (+)	MAPPER	mRatBN7.2
Rnor_6.0	12	13,631,273 - 13,631,453	NCBI	Rnor6.0
Rnor_5.0	12	15,667,888 - 15,668,068	UniSTS	Rnor5.0
Celera	12	13,369,798 - 13,369,978	UniSTS
RH 3.4 Map	12	156.3	UniSTS
Cytogenetic Map	12	p11	UniSTS

RH137434

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	12	11,550,021 - 11,550,219 (+)	MAPPER	mRatBN7.2
Rnor_6.0	12	13,605,249 - 13,605,446	NCBI	Rnor6.0
Rnor_5.0	12	15,641,864 - 15,642,061	UniSTS	Rnor5.0
RGSC_v3.4	12	11,949,352 - 11,949,549	UniSTS	RGSC3.4
Celera	12	13,343,917 - 13,344,114	UniSTS
Cytogenetic Map	12	p11	UniSTS

RH137509

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	12	11,470,103 - 11,470,644 (+)	MAPPER	mRatBN7.2
mRatBN7.2	12	34,761,961 - 34,762,178 (+)	MAPPER	mRatBN7.2
Rnor_6.0	12	40,274,101 - 40,274,317	NCBI	Rnor6.0
Rnor_6.0	12	13,523,743 - 13,524,283	NCBI	Rnor6.0
Rnor_5.0	12	42,145,058 - 42,145,274	UniSTS	Rnor5.0
Rnor_5.0	12	15,562,742 - 15,563,282	UniSTS	Rnor5.0
RGSC_v3.4	12	35,966,790 - 35,967,006	UniSTS	RGSC3.4
RGSC_v3.4	12	11,865,825 - 11,866,365	UniSTS	RGSC3.4
Celera	12	13,264,657 - 13,265,197	UniSTS
Celera	12	36,426,782 - 36,426,998	UniSTS
RH 3.4 Map	12	616.2	UniSTS
Cytogenetic Map	12	q16	UniSTS
Cytogenetic Map	12	p11	UniSTS

RH140401

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	12	11,459,101 - 11,459,318 (+)	MAPPER	mRatBN7.2
Rnor_6.0	12	13,512,742 - 13,512,958	NCBI	Rnor6.0
Rnor_5.0	12	15,551,741 - 15,551,957	UniSTS	Rnor5.0
RGSC_v3.4	12	11,854,823 - 11,855,039	UniSTS	RGSC3.4
Celera	12	13,253,666 - 13,253,882	UniSTS
RH 3.4 Map	12	154.5	UniSTS
Cytogenetic Map	12	p11	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
16	12	67	165	91	90	59	92	59	6	356	192	11	144	81	92	31	17	17

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001107122	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_001437315	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_001437316	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_001437317	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_001437318	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039089363	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039089364	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039089366	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039089367	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063271261	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063271262	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	CH474012	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ230425	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000012	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000001458 ⟹ ENSRNOP00000001458

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	12	16,568,347 - 16,689,868 (+)	Ensembl
mRatBN7.2 Ensembl	12	11,454,797 - 11,576,304 (+)	Ensembl
Rnor_6.0 Ensembl	12	13,508,429 - 13,631,689 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000083976 ⟹ ENSRNOP00000074315

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0 Ensembl	12	13,508,933 - 13,632,304 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000141157 ⟹ ENSRNOP00000105271

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	12	16,568,667 - 16,690,989 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000157770 ⟹ ENSRNOP00000101714

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	12	16,568,667 - 16,689,867 (+)	Ensembl

RefSeq Acc Id:

NM_001107122 ⟹ NP_001100592

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	12	16,568,373 - 16,689,867 (+)	NCBI
mRatBN7.2	12	11,454,797 - 11,576,304 (+)	NCBI
Rnor_6.0	12	13,508,429 - 13,631,689 (+)	NCBI
Rnor_5.0	12	15,547,724 - 15,668,304 (+)	NCBI
RGSC_v3.4	12	11,850,549 - 11,968,127 (+)	RGD
Celera	12	13,249,412 - 13,370,214 (+)	RGD

Sequence:

show sequence

CGCAGTAGCGGCCTCGGCGGCAGCGGCGGCGGCGACGACAGCATTGGCAGTGGCGGCTGTAGCA
GCGGGGAAGCTTTTCGAGCGGATGCTTCAGAACAGATGATCACCATGTCTGGGTTCTAGCAATC
ACATACGTTTATATCTGAATTTGAAAATGGCAGAGGGAAACAACCAAGAGGAGGTCATTCACTT
GAACAACTTTCACTGCCACCGGGGGAAGGAGTGGATGGCTGTCAGAGAGGGGCCCATCACCATA
TCTGACTCCTCTGATGAGGAAGGGATTCCAATGCTGGTTACCCCGGCTACTGAGCAACAGGAAG
ACGACCTGGATGATGATGTCATCCTGACAGAAACACATAAACCTCAGACATCCCGGCCCAATCT
CATCAAACCAGCTGCCGAGTGGCAAGATCTGAACAGATTGGGAGAAGAAAGGCCTAGAAAATCT
AGAGCAGACTTTGAAGCAGATACCCACAGCTATTTTTCCTTTTGTAACAACTCATTGTTTGATT
CTGGGGCACAGGATGATTCTGAGGATGAATGTGGTGGATTTCTGGATCTTAAGACTGAGAAAAA
AGGAGGAGAAGCCAAACCTGGACCAAGCAATAAGCAGACAGCAGACAATACTGTCAGCCCCAGG
CTGGAGCAGAAAGTCATTATTTTGGGAGAAAATGGTCTTCTTTTTTCAGAAAGTGAGCCTCTGG
AAGTTCAGAACCAATTATCTGAAGACTCAGAGACAGATCTTTTATCAAATCCTGGTGAGCCAGC
TGCCTCAGTAGATGAGCAGCTAATTGAAGAAGAGTACTGGCTTGACCATCCCTACTTCCAGGCT
CTGAATCCACAGCCTCAGGAGAGAACAAACCAGCTTGTGCCCCAAGAGCGACATTCTGAATCAG
AAATGGGCCCAATGTTTTTCCGCCATGATTTCCCGGAGCCAGCTTTTCCAAGGCCAGAACCCCA
GCAGGAGGGGATTCCAGGACCCGCTTCTCCACAACCAGCCCATCCTCTAGGAGAGCTTGAAGAC
CAGCAATTAGCAATTGATGAAGACCCTGGGCCTGCCTACCCCCTGCCAGGACCCCAGGAGGCCA
ATTTGGCAAATGTGTGGGGACAAGAAGCTGCTGAAGGGGATCAAGAGCTCATTCCACTGTTAGT
GAAAGAAACGGAAGCAAGATTTCCAGACGTAGCAAATGGATATGTTGAAGAGATAATTCATTTG
AAAAATTACTATGATTTGAATGTACTTTGTAATTTTCTCCTGGAAAATCCAGATTATCCAAAGA
GAGAAGACCGAATCCTTATCCACCCCAGCAGTAGCCTGCTTGCCAGCCAGGATGATGTGAAGTT
GCCTAAGATAGACTTTTTTGACTATTCCAAATTGACTCCACTTGACCAGCGCTGCTTCATCCAA
GCTGCTGACCTCTTGATGGCTGATTTCAAGATGCTCAGCAGCCAGGACATCAAGTGGGCCCTGC
ACGAGCTCAAAGGGCATTACGCAATCACCCGAAAGGCCTTTTCTGATGCCATTAAAAAATGGCA
GGAGCTATCACCTGAAACCAGTGGAAAGCGGAAAAAGAGGAAAGAAATGAATCAGTATTCTTTC
ATAGACTTCAAATTTGAACAAGGTAACATAAAAATAGAAAAGAGGATGTTCTTTCTGGAAAACA
AGCGTCGACACTGTAGGTCCTATGACCAGCAGGCCCTCCTTCCAGCTGTGCAGCAAGAGCAGGA
GTTCTATGAGCAGAAAATTAAAGAGATGGCAGAGCACGAAGATTTTTTGCTTGCCCTGCAGATG
AATGAAGAGCAGTATCAAAAGGATGGCCAGCTGATTGAATGCCGCTGCTGCTATGGGGAGTTTC
CATTTGAGGAGCTGACACAATGCGCTGATGCTCACTTGTTCTGCAAAGAATGTCTCATCAGATA
TGCCCAAGAGGCCGTGTTTGGATCTGGAAAGTCAGAGCTCAGCTGCATGGAAGGCAGCTGCACA
TGTTCCTTCCCAACCAGTGAACTGGAGAAAGTGCTCCCCCAGACCATTCTGTACAAATACTATG
AACGGAAAGCTGAAGAGGAAGTCGCAGCAGCCTATGCTGACGAGCTTGTCCGGTGCCCCTCTTG
CAGCTTCCCTGCTCTGTTGGACAGCGATGTGAAGAGGTTCAGCTGCCCTAACCCTCGCTGCCGA
AAGGAGACCTGTAGGAAGTGTCAGGGACTCTGGAAAGAACACAATGGCCTCACCTGTGAAGAGC
TGGCAGAAAAGGATGACATCAAGTACCGGACATCTATTGAAGAAAAAATGACTGCTGCTCGAAT
TAGAAAATGCCACAAGTGTGGGACTGGCCTCATCAAATCTGAAGGCTGCAACCGCATGTCTTGC
CGCTGTGGTGCCCAGATGTGCTACCTCTGTCGAGTTTCTATCAATGGCTATGACCACTTCTGCC
AGCATCCTCGCTCTCCAGGAGCCCCTTGCCAGGAATGTTCCAGGTGCTCCCTCTGGACCGACCC
CACTGAAGATGATGAGAAGCTGATTGAGGAGATCCAAAAGGAGGCTGAGGAGGAGCAGAAAAGA
AAGAATGGAGAGAACACTTTCAAACGCATCGGGCCCCCACTGGAGAAGCCGGCTGAGAAAGTGC
AGCGTGTGGAAGCCCTGCCACGGCCTGTCCCACAGAACCTGCACCCTCAGATGCCACCCTATGC
CTTTGTCCACCCACCCTTCCCCCTGCCACCTGTGCGGCCCGTGTTCAACAACTTCCCCATCAAC
ATGGGTCCTGTGCCCGCACCCTATGTACCCCCTCTGCCCAACGTGCGTGTCAACTTCGACTTTG
GCCACGTGCATGTGCCCCTGGAGCACAACCTGCCCATGCACTTTGGCCCCCAACCACGGCATCG
CTTCTGACACCCAAAGCCCTGTCCAGCTGTGCTGAGTCTGCAGGAGGACCCAGTCTCATCCTCT
GAGTAGGGATGAAGTCCTCGACTCCCTATGGGGTGTGGGCTCGTGTCCTCCTGCTCTTCCCGTT
GCGAGGTCCACTGCTCCTTCGGGTCTGATGCGCCTTGGGTGCTGACTGTCGCTGCACCAGTAAT
AGGGCAGCTCCCCGGGTCTGCCATCTATCTTAGCAGCCAGTCCAGGGGCCTTGGCCGAGAAGCA
GGCCCTTTAAGCATTTGCCATACTTCCTCCCCAGCAGACCACTGAAAGCCCAAGGGAAAATGGC
CTACCCTCCCCAGGCCAGGGCTCTCTCCTTGTTGCCCAAGGCCCACTCAGGTCCAAGGGCCGCC
AAGAATCTTCTGTGGCGCAAGTTTTGTTCTGTTGTTACCTAGAGGTTGCTCCTATTCACATAGT
TTGAGCTGAAGTTTTTTGTGTGTCCCCATCCGTGGAAAGTCAGGTTGAAGGTATTTCCCCAGGG
CTGGCAACTGCTGAGAACCAGTAGTCCTGACACTTGACATCAAACAGAAGGACCCTTTTAGGGC
CCTTTATTCCTGGGCTGCCCCTTTTCTGGGAGAGACCTCACTTGTCACCAACCTGGGATGAGCA
GCATCTCTCCTAAGGTTTTTAGGGGCTTCCCTAGCAGTGCAGATGACCTCATGGAGCTGCTGCA
GCTATCACAGCAACCCTCCTGCCCGCTCAGCTGTCCCTCACTAGTTAGCAGTGGATGCAGACAG
GAGAGGTCTAGCTCCAAGATGAGGACAGCTGGCTTCCCTAGAGTCAGATGAAAATCGGCCTGCA
CAGTCTTTGCCATGTTCCCACTACCTGTGTCCCCTCCTGTCCAGACCAGATCTTTATACTCTCC
TCCAGTGTGTGTTGACCAGGGCTGATAGCAAGTGTCTCACTCAGTTGTACTGGCTGTCCTTGTC
GTGGAGTGTCCCATGTTCAGAGTGTACAGACTTAGAAGAGAGAAGATGTCCCTGGGAAAAGGAA
AGACTCCCTGAGGTGCCCACTGTCACTGGAGTGTGGGTAGGGCACACAGGGCAACTCAGGAGCC
CTGCCATGGGTCACCTGAACTGTGATGCTAGTCTGAATGACAGTGCCTTGGAAAGATGGGCCAC
ATGCTGCATGACAGGATCCTCCAAGTACCTTAACAATTAGTGTACTCGTGTTCTCTGCACTTCT
CCAGAAGCCCTGCAGGGGGCGGTACTCCGAGCACTGCCCCTCCAAGGCCTCATGAGCCGCTGGA
CTGGGCACCCAGTTCTGGGCGCCTCAGTACCCTATCACATTGTTCCACCAAGAGGCCAGATGGA
AAAACTGGCAGTTTCTGGGGTAGCTGGAAGAGCAGGCCAGGCAGGTGCCATCCAGACCCTGGCA
CTCCATTTGGAGAGGTGAGGCCAGAGACGTATCCTTCAAAATATTGTCAGTCTGTGACAGGGAG
ACTGCTACTGCCTGTCTCCATCAAGGAGTGACCCTCCCATGTTGCCAGCAGGGCTAGGGAGTGA
GGGGTGGGCCAGCAAGGATCCCCAAGGCAGCTGCCACCTTAACCCCTAGGACCCAGACTGCTTC
CTGGTTTAAGAAACTGCCTAGCCACTCCCAGTGTATTTGCCTTAAAACTGGAGAGAATCTAGTA
TTTGCACTTAGCAAAAGATTTCAAAGTTAAGAGAAAAGTGCATGATCTCACTTTGTACAAAAGA
AAAAAAGGAAAAAAAATGAAGTAGATGGTTAAACGTTTTTCTTTACCTTTTGGTAGTAAAAATA
GAGAAAACAAGTCTGTTTAAACTACTGTGTAAAAAGACTGTATCATATGTAACTTGAATTTTGT
GTAAATAAATGTTTGTGAACGCT

hide sequence

RefSeq Acc Id:

XM_039089363 ⟹ XP_038945291

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	12	16,568,391 - 16,689,868 (+)	NCBI
mRatBN7.2	12	11,454,816 - 11,576,305 (+)	NCBI

RefSeq Acc Id:

XM_039089364 ⟹ XP_038945292

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	12	16,568,327 - 16,689,868 (+)	NCBI
mRatBN7.2	12	11,454,752 - 11,576,305 (+)	NCBI

RefSeq Acc Id:

XM_039089366 ⟹ XP_038945294

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	12	16,568,887 - 16,689,868 (+)	NCBI
mRatBN7.2	12	11,455,312 - 11,576,305 (+)	NCBI

RefSeq Acc Id:

XM_039089367 ⟹ XP_038945295

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	12	16,568,391 - 16,689,868 (+)	NCBI
mRatBN7.2	12	11,454,816 - 11,576,305 (+)	NCBI

RefSeq Acc Id:

XM_063271261 ⟹ XP_063127331

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	12	16,568,327 - 16,689,868 (+)	NCBI

RefSeq Acc Id:

XM_063271262 ⟹ XP_063127332

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	12	16,568,887 - 16,689,868 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_001100592	(Get FASTA)	NCBI Sequence Viewer
	NP_001424244	(Get FASTA)	NCBI Sequence Viewer
	NP_001424245	(Get FASTA)	NCBI Sequence Viewer
	NP_001424246	(Get FASTA)	NCBI Sequence Viewer
	NP_001424247	(Get FASTA)	NCBI Sequence Viewer
	XP_038945291	(Get FASTA)	NCBI Sequence Viewer
	XP_038945292	(Get FASTA)	NCBI Sequence Viewer
	XP_038945294	(Get FASTA)	NCBI Sequence Viewer
	XP_038945295	(Get FASTA)	NCBI Sequence Viewer
	XP_063127331	(Get FASTA)	NCBI Sequence Viewer
	XP_063127332	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	EDL89689	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000001458
	ENSRNOP00000001458.7
	ENSRNOP00000101714
	ENSRNOP00000101714.1
	ENSRNOP00000105271.1

RefSeq Acc Id:

NP_001100592 ⟸ NM_001107122

- UniProtKB:

D3ZU60 (UniProtKB/TrEMBL), A6K1N1 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MAEGNNQEEVIHLNNFHCHRGKEWMAVREGPITISDSSDEEGIPMLVTPATEQQEDDLDDDVIL
TETHKPQTSRPNLIKPAAEWQDLNRLGEERPRKSRADFEADTHSYFSFCNNSLFDSGAQDDSED
ECGGFLDLKTEKKGGEAKPGPSNKQTADNTVSPRLEQKVIILGENGLLFSESEPLEVQNQLSED
SETDLLSNPGEPAASVDEQLIEEEYWLDHPYFQALNPQPQERTNQLVPQERHSESEMGPMFFRH
DFPEPAFPRPEPQQEGIPGPASPQPAHPLGELEDQQLAIDEDPGPAYPLPGPQEANLANVWGQE
AAEGDQELIPLLVKETEARFPDVANGYVEEIIHLKNYYDLNVLCNFLLENPDYPKREDRILIHP
SSSLLASQDDVKLPKIDFFDYSKLTPLDQRCFIQAADLLMADFKMLSSQDIKWALHELKGHYAI
TRKAFSDAIKKWQELSPETSGKRKKRKEMNQYSFIDFKFEQGNIKIEKRMFFLENKRRHCRSYD
QQALLPAVQQEQEFYEQKIKEMAEHEDFLLALQMNEEQYQKDGQLIECRCCYGEFPFEELTQCA
DAHLFCKECLIRYAQEAVFGSGKSELSCMEGSCTCSFPTSELEKVLPQTILYKYYERKAEEEVA
AAYADELVRCPSCSFPALLDSDVKRFSCPNPRCRKETCRKCQGLWKEHNGLTCEELAEKDDIKY
RTSIEEKMTAARIRKCHKCGTGLIKSEGCNRMSCRCGAQMCYLCRVSINGYDHFCQHPRSPGAP
CQECSRCSLWTDPTEDDEKLIEEIQKEAEEEQKRKNGENTFKRIGPPLEKPAEKVQRVEALPRP
VPQNLHPQMPPYAFVHPPFPLPPVRPVFNNFPINMGPVPAPYVPPLPNVRVNFDFGHVHVPLEH
NLPMHFGPQPRHRF

hide sequence

Ensembl Acc Id:

ENSRNOP00000074315 ⟸ ENSRNOT00000083976

Ensembl Acc Id:

ENSRNOP00000001458 ⟸ ENSRNOT00000001458

RefSeq Acc Id:	XP_038945292 ⟸ XM_039089364
- Peptide Label:	isoform X1

RefSeq Acc Id:	XP_038945291 ⟸ XM_039089363
- Peptide Label:	isoform X1

RefSeq Acc Id:	XP_038945295 ⟸ XM_039089367
- Peptide Label:	isoform X2

RefSeq Acc Id:	XP_038945294 ⟸ XM_039089366
- Peptide Label:	isoform X1

RefSeq Acc Id:	XP_063127331 ⟸ XM_063271261
- Peptide Label:	isoform X2

RefSeq Acc Id:	XP_063127332 ⟸ XM_063271262
- Peptide Label:	isoform X2

Ensembl Acc Id:

ENSRNOP00000105271 ⟸ ENSRNOT00000141157

Ensembl Acc Id:

ENSRNOP00000101714 ⟸ ENSRNOT00000157770

Protein Domains

RING-type

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-D3ZU60-F1-model_v2	AlphaFold	D3ZU60	1-910	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13698444

Promoter ID:

EPDNEW_R8969

Type:

initiation region

Name:

Rnf216_1

Description:

ring finger protein 216

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	12	13,508,432 - 13,508,492	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1565135	AgrOrtholog
BioCyc Gene	G2FUF-19988	BioCyc
Ensembl Genes	ENSRNOG00000001101	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000001458	ENTREZGENE
	ENSRNOT00000001458.9	UniProtKB/TrEMBL
	ENSRNOT00000141157.1	UniProtKB/TrEMBL
	ENSRNOT00000157770	ENTREZGENE
	ENSRNOT00000157770.1	UniProtKB/TrEMBL
Gene3D-CATH	1.20.120.1750	UniProtKB/TrEMBL
	3.30.40.10	UniProtKB/TrEMBL
InterPro	BRcat_RBR_RNF216	UniProtKB/TrEMBL
	LUBAC_E3_Ligases	UniProtKB/TrEMBL
	Rcat_RBR_RNF216	UniProtKB/TrEMBL
	RING-HC_RBR_RNF216	UniProtKB/TrEMBL
	TRIAD_supradom	UniProtKB/TrEMBL
	Znf_C6HC	UniProtKB/TrEMBL
	Znf_RING/FYVE/PHD	UniProtKB/TrEMBL
KEGG Report	rno:304294	UniProtKB/TrEMBL
NCBI Gene	304294	ENTREZGENE
PANTHER	E3 UBIQUITIN-PROTEIN LIGASE RNF216	UniProtKB/TrEMBL
	UBIQUITIN CONJUGATING ENZYME 7 INTERACTING PROTEIN-RELATED	UniProtKB/TrEMBL
Pfam	IBR_1	UniProtKB/TrEMBL
PhenoGen	Rnf216	PhenoGen
PROSITE	TRIAD	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000001101	RatGTEx
SMART	IBR	UniProtKB/TrEMBL
Superfamily-SCOP	RING/U-box	UniProtKB/TrEMBL
UniProt	A0ABK0L925_RAT	UniProtKB/TrEMBL
	A0ABK0LL71_RAT	UniProtKB/TrEMBL
	A6K1N1	ENTREZGENE, UniProtKB/TrEMBL
	D3ZU60	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2008-03-06	Rnf216	ring finger protein 216	RGD1565135_predicted	similar to E3 ubiquitin ligase TRIAD3B (predicted)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2006-03-07	RGD1565135_predicted	similar to E3 ubiquitin ligase TRIAD3B (predicted)	LOC304294	similar to E3 ubiquitin ligase TRIAD3B	Symbol and Name status set to approved	1299863	APPROVED
2006-02-09	LOC304294	similar to E3 ubiquitin ligase TRIAD3B			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

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