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Gene: Crb3 (crumbs cell polarity complex component 3) Rattus norvegicus

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Symbol:

Crb3

Name:

crumbs cell polarity complex component 3

RGD ID:

1565035

Description:

Predicted to enable SH3 domain binding activity. Predicted to be involved in positive regulation of cell junction assembly and protein localization to plasma membrane. Part of protein-containing complex. Orthologous to human CRB3 (crumbs cell polarity complex component 3); INTERACTS WITH 17alpha-ethynylestradiol; 2,4-dinitrotoluene; 2,6-dinitrotoluene.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

crumbs 3, cell polarity complex component; crumbs family member 3; crumbs homolog 3; crumbs homolog 3 (Drosophila); crumbs protein homolog 3; LOC301112; MGC114421; similar to Crumbs homolog 3

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	9	1,985,504 - 1,990,855 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	9	1,983,619 - 1,993,486 (+)	Ensembl				GRCr8
mRatBN7.2	9	1,898,531 - 1,903,860 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	9	1,896,623 - 1,903,859 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	9	2,334,695 - 2,337,797 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	9	7,684,052 - 7,687,154 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	9	6,639,913 - 6,643,015 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	9	9,982,529 - 9,986,896 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	9	9,980,720 - 9,985,630 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	9	8,981,382 - 8,990,122 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
Celera	9	6,613,602 - 6,616,703 (-)	NCBI		Celera
Cytogenetic Map	9	q11	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene (ISO)

17alpha-ethynylestradiol (EXP,ISO)

17beta-estradiol (ISO)

2,2',4,4',5,5'-hexachlorobiphenyl (ISO)

2,2',5,5'-tetrachlorobiphenyl (ISO)

2,4,4'-trichlorobiphenyl (ISO)

2,4-dibromophenyl 2,4,5-tribromophenyl ether (ISO)

2,4-dinitrotoluene (EXP)

2,6-dinitrotoluene (EXP)

2-hydroxypropanoic acid (ISO)

4,4'-sulfonyldiphenol (ISO)

4-hydroxyphenyl retinamide (ISO)

6-propyl-2-thiouracil (EXP)

acetamide (EXP)

amiodarone (ISO)

amitrole (EXP)

aristolochic acid A (ISO)

benzo[a]pyrene (ISO)

bis(2-chloroethyl) sulfide (ISO)

bisphenol A (EXP,ISO)

bisphenol F (ISO)

cadmium dichloride (EXP,ISO)

carbon nanotube (ISO)

chlorpyrifos (ISO)

ciguatoxin CTX1B (ISO)

DDE (ISO)

decabromodiphenyl ether (EXP)

endosulfan (EXP)

ethanol (ISO)

fipronil (EXP)

glycidol (EXP)

imidacloprid (EXP)

lead diacetate (EXP,ISO)

lead(0) (ISO)

methapyrilene (EXP)

methimazole (EXP)

ozone (ISO)

paracetamol (ISO)

PCB138 (ISO)

pirinixic acid (ISO)

rac-lactic acid (ISO)

sodium arsenite (ISO)

sulfadimethoxine (EXP)

sulforaphane (ISO)

sunitinib (ISO)

thioacetamide (EXP)

titanium dioxide (ISO)

triphenyl phosphate (EXP)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

positive regulation of cell junction assembly (IEA,ISO)

protein localization to plasma membrane (IEA,ISO)

tight junction organization (IEA,ISO)

Cellular Component

apical part of cell (IEA,ISO)

apical plasma membrane (IEA,ISO)

cell junction (IEA,ISO)

protein-containing complex (IDA)

subapical complex (IEA,ISO)

tight junction (IEA,ISO)

Molecular Function

protein binding (ISO)

protein domain specific binding (IEA,ISO)

SH3 domain binding (IEA,ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
2.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
3.	Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.	Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
4.	Par3/Par6 polarity complex coordinates apical ectoplasmic specialization and blood-testis barrier restructuring during spermatogenesis.	Wong EW, etal., Proc Natl Acad Sci U S A. 2008 Jul 15;105(28):9657-62. Epub 2008 Jul 10.

Additional References at PubMed

PMID:17332497	PMID:19056867	PMID:24191021	PMID:27358069

Genomics

Comparative Map Data

Crb3
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	9	1,985,504 - 1,990,855 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	9	1,983,619 - 1,993,486 (+)	Ensembl				GRCr8
mRatBN7.2	9	1,898,531 - 1,903,860 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	9	1,896,623 - 1,903,859 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	9	2,334,695 - 2,337,797 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	9	7,684,052 - 7,687,154 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	9	6,639,913 - 6,643,015 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	9	9,982,529 - 9,986,896 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	9	9,980,720 - 9,985,630 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	9	8,981,382 - 8,990,122 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
Celera	9	6,613,602 - 6,616,703 (-)	NCBI		Celera
Cytogenetic Map	9	q11	NCBI

CRB3
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	19	6,463,777 - 6,467,221 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	19	6,463,777 - 6,467,221 (+)	Ensembl			hg38	GRCh38
GRCh37	19	6,463,788 - 6,467,232 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	19	6,415,260 - 6,418,232 (+)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	19	6,414,787 - 6,418,228	NCBI
Celera	19	6,404,086 - 6,407,058 (+)	NCBI		Celera
Cytogenetic Map	19	p13.3	NCBI
HuRef	19	6,227,050 - 6,230,022 (+)	NCBI		HuRef
CHM1_1	19	6,463,843 - 6,466,815 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	19	6,450,245 - 6,456,708 (+)	NCBI		T2T-CHM13v2.0

Crb3
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	17	57,368,583 - 57,372,920 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	17	57,366,105 - 57,372,918 (+)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	17	57,062,201 - 57,065,918 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	17	57,059,105 - 57,065,918 (+)	Ensembl			mm10	GRCm38
MGSCv37	17	57,201,700 - 57,205,341 (+)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	17	56,747,424 - 56,751,065 (+)	NCBI		MGSCv36	mm8
Celera	17	61,410,197 - 61,413,838 (+)	NCBI		Celera
Cytogenetic Map	17	D	NCBI
cM Map	17	29.65	NCBI

Crb3
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0	NW_004955495	3,148,729 - 3,152,269 (-)	NCBI	ChiLan1.0	ChiLan1.0

CRB3
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	20	10,866,380 - 10,875,309 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	19	10,092,301 - 10,101,234 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	19	5,485,925 - 5,494,853 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	19	6,414,371 - 6,417,492 (+)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	19	6,414,370 - 6,417,485 (+)	Ensembl			panPan2	panpan1.1

CRB3
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	20	53,717,844 - 53,722,127 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	20	53,718,103 - 53,720,381 (-)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	20	53,462,717 - 53,469,203 (-)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	20	54,369,642 - 54,376,128 (-)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	20	54,372,056 - 54,374,326 (-)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	20	53,436,493 - 53,442,980 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	20	53,884,931 - 53,891,420 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	20	54,113,911 - 54,120,402 (-)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Crb3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405118	214,020,381 - 214,029,991 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936588	3,808,839 - 3,814,801 (+)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936588	3,806,193 - 3,811,718 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

CRB3
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	2	72,618,105 - 72,623,344 (-)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	2	72,618,059 - 72,623,266 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	2	73,046,032 - 73,049,051 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

CRB3
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	6	6,062,459 - 6,070,989 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	6	6,068,459 - 6,070,771 (+)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666081	1,927,022 - 1,930,354 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Crb3
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624828	3,571,833 - 3,578,281 (+)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Crb3
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	4	88,440,620 - 88,444,128 (+)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Crb3
49 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	315
Count of miRNA genes:	184
Interacting mature miRNAs:	205
Transcripts:	ENSRNOT00000071780
Prediction methods:	Microtar, Miranda, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
631533	Iresp3	Immunoglobin response QTL3	16.2		blood immunoglobulin E amount (VT:0002492)	serum immunoglobulin E level (CMO:0002101)	9	1	6094576	Rat
10054141	Gmadr4	Adrenal mass QTL 4	2.45	0.0074	adrenal gland mass (VT:0010420)	both adrenal glands wet weight (CMO:0000164)	9	1	21707400	Rat
9589158	Gluco65	Glucose level QTL 65	6.82	0.001	blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	9	496645	45496645	Rat
7411592	Foco8	Food consumption QTL 8	7.4	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	9	496645	45496645	Rat
7207814	Bmd91	Bone mineral density QTL 91	3.5		femur size trait (VT:1000369)	femoral neck cross-sectional area (CMO:0001697)	9	1	31250552	Rat
9589055	Scfw5	Subcutaneous fat weight QTL 5	5.55	0.001	subcutaneous adipose mass (VT:1000472)	abdominal subcutaneous fat pad weight (CMO:0002069)	9	496645	45496645	Rat
1300124	Cm4	Cardiac mass QTL 4	3.55		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	9	1	41763315	Rat

Markers in Region

AU015179

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	9	1,903,660 - 1,903,786 (-)	MAPPER	mRatBN7.2
Rnor_6.0	9	9,982,603 - 9,982,728	NCBI	Rnor6.0
Rnor_5.0	9	8,981,456 - 8,981,581	UniSTS	Rnor5.0
Celera	9	6,613,676 - 6,613,801	UniSTS
Cytogenetic Map	9	q11	UniSTS

RH131689

Rat Assembly	Chr	Position (strand)	Source	JBrowse
GRCr8	9	1,990,119 - 1,990,670 (+)	Marker Load Pipeline
mRatBN7.2	9	1,903,124 - 1,903,675 (-)	MAPPER	mRatBN7.2
Rnor_6.0	9	9,982,714 - 9,983,264	NCBI	Rnor6.0
Rnor_5.0	9	8,981,567 - 8,982,117	UniSTS	Rnor5.0
Celera	9	6,613,787 - 6,614,337	UniSTS
Cytogenetic Map	9	q11	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
16	12	63	141	91	90	59	69	59	6	328	164	9	115	81	90	31	11	11

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001025661	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_001431889	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_001431892	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_001431894	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_001431896	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006244303	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017596317	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017596318	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_010054571	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	BC097382	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH474092	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ223867	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000009	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000071780 ⟹ ENSRNOP00000064452

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0 Ensembl	9	9,982,530 - 9,985,630 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000080856 ⟹ ENSRNOP00000070535

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0 Ensembl	9	9,980,720 - 9,985,358 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000119595 ⟹ ENSRNOP00000078595

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	9	1,983,619 - 1,990,854 (+)	Ensembl
mRatBN7.2 Ensembl	9	1,896,623 - 1,903,859 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000172872 ⟹ ENSRNOP00000112488

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	9	1,987,705 - 1,993,486 (+)	Ensembl

RefSeq Acc Id:

NM_001025661 ⟹ NP_001020832

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	9	1,987,754 - 1,990,855 (+)	NCBI
mRatBN7.2	9	1,900,758 - 1,903,860 (+)	NCBI
Rnor_6.0	9	9,982,529 - 9,985,630 (-)	NCBI
Rnor_5.0	9	8,981,382 - 8,990,122 (-)	NCBI
Celera	9	6,613,602 - 6,616,703 (-)	RGD

Sequence:

show sequence

CTGGGAACCCGGGATTGGAAACCTGAGCGAAGTCCCTCTCTGACGCCTGGGTCAGGTCCTGGGT
CGCAGGTGCCCTCCTCGACCCAAGATGCGGTAGGAATTGGAGCCCTGGGGAAGTCCTGTCCTTG
GCGCCACCAACTCGTCGCCCAAGCTCATGGCGACCCCAGGCCTGGGGCTGCTCTTGGCGTTTGG
CTTGCCGATGCTGCCCTCCGGCTGGAGCCAAGAAACACCAGACTCTTTCACAAATAGCACAACT
CAACCCCCAGATGGCGGCGGGTCCAACGGGGGCTTGTCCTCAGAGGCCATCGTGGCCATCACTG
TGGTCTTTTCCATTCTGGGAACCCTCCTCATAGCAGTGGGGCTATTCCTGCTAATGAGAAAACT
TCGAGAAAAGCGGCAGACAGAGGGCACCTACCGGCCCAGCAGTGAGGAGCAGGTGGGTGCCCGT
GCTCCACCACCCCCCAACCTCAAGCTGCCCCCGGAGGAGCGGCTCATCTGAATTTAGGGGTGTT
GGCCATAGGCCATCATCACGACCAACGCCCAGGACTGCCTTGGCACACCGAGACACACAGCAGC
CACCTTGGAGACAACAGCCTCTGATGACTCAGGAGGACTTGGCTTGGGGAACCCTGGGGCATCC
AGCTGGTGGGCTATACAGCATGTTGCTTCTGCTTGGCTCTGCATGAAACTGGGGGTGCCAGGAC
CAGGGGCGGGGAGCCTTACCATTTACCTCATGTGATCTTGCCTCTGCTGTGTCTCCTACTGTGA
CCGCAGGCCCAACAAACTTCCTGTCCTTTCTTTCAGTTTTCCCACGCAGCAGCTGAGGCCCGGG
CCCCCCAGGACTCCAAGGAGCCAGTGCGGGGCTGCCTGCCCATCTAGCTCCTCCCCTCCTTCCC
TGTCATCCATCTTCCCTTCCTGGCTGTGTGACCTTGTGGAAGGCTTGGGCAGTCAGACTCATAC
AATACTCAATAGAAGGGGAGAGAGTTCTTCAGAGACCTTGACTTTGAGGGCAAGCGAGGATGGG
GCTACTCACTTTTTATATATTTATATGAAATTGATAGGTACAATAAAGGTTTCTTGTTTTTGTT
TTTTTAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

hide sequence

RefSeq Acc Id:

XM_006244303 ⟹ XP_006244365

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	9	1,985,504 - 1,990,855 (+)	NCBI
mRatBN7.2	9	1,898,531 - 1,903,860 (+)	NCBI
Rnor_6.0	9	9,982,529 - 9,986,896 (-)	NCBI
Rnor_5.0	9	8,981,382 - 8,990,122 (-)	NCBI

Sequence:

show sequence

CTGGAACTCACAAAGATCCACCTGTTTTTGCTGGGATCTAAGGCATATGCCACTACAATGGGCG
TTGTAGGGCTTTGTATGGCTTAGTCAATCTAGACAACAAACTCCAGCTCCAGCCCTCTGACTGT
TGTTATTGCACTTTTGACTCAAGTTCTCTGGGGCTTAGCTGGCCTTGATTGTGCAGCAATTCGC
CTGCTTCTGATTCCCCATTGCCGGGACGGTAAATCATGTGCTATCATATCCGGTTCATGACCAC
CTTTTACCCAAAGATACATCAGGAGGTCGTGTGGTTCCGGACAGGTGTTTGGTGAAGAGGTGAA
AGTCTCACCCCAGCCCTCTACCAGCTACCAAAGGTTTCCATGCATACGTGTTTCTTTGTGGACG
CCATGGGACATAACTGCTTCTGCACAGACCCAAATCCATTCTTTCCCCCAAACACTTCCCTGAC
AGGTGGGCCTGTCATACGGACTTTTTTCAGTGCGAACATAAGGCCTTCCATTAAGCTGAGCGGG
ATTCTGCGCAGGGGCTTGTCTAGGTGTGTTTTTTACCGCACGGGTTTAATTCTAAGCAGGTGTT
CTGATTACTCTGACTACAAGTCCACATTGTGTATCTTTCTACGAAACTAGTCCTGTACAAGTTG
ATTGATTGACTATGGGATAAAGAAGGAACCCAGGGTCTCAGGCATGCTGAATTCATAGCTGAGA
AAAGGGCGATGCCGTCACTAAGACATTCTTGGCAGGTGACCTTCACTAGGTGATTCTAGGCAAG
GTTTCTGGCCCTGAGCCACGCTCCCAGCCATTTTACTTTTGAAATAGGATTTGCTCAGGCTGGC
CTTGAACTTGTGATCCTCTGGCCTCCGCCTCCAGAATACACTTAGGATTCAGGTTAGCATTACC
AGATCTGACGTCAGTATGAATCAGTGTTACCCATCGGAGACCGCCCTTTACAGGTGTGTATCTT
TCTGGAGTGTCGCCACGCCCCCTGCGTCTGCACACCTGTGCCACAGAGGGACCCCAGCTGTGCA
GTCCTTTCACCTGCTCGCTTCCGCCCTCCGCGCAGCTCCTTGTCGCAATGGGGTTCCCGTTACA
GGTGCTCTGGCGGCGCGGCCCCGCCCTCTTCGCCCCGCCCTCTCAGCCAGGCTCAGGTGCACAA
GCCGGAAGTGCGCTCTTTGCCTAGGTCCTGGGTCGCAGGTGCCCTCCTCGACCCAAGATGCGGT
AGGAATTGGAGCCCTGGGGAAGTCCTGTCCTTGGCGCCACCAACTCGTCGCCCAAGCTCATGGC
GACCCCAGGCCTGGGGCTGCTCTTGGCGTTTGGCTTGCCGATGCTGCCCTCCGGCTGGAGCCAA
GAAACACCAGACTCTTTCACAAATAGCACAACTCAACCCCCAGATGGCGGCGGGTCCAACGGGG
GCTTGTCCTCAGAGGCCATCGTGGCCATCACTGTGGTCTTTTCCATTCTGGGAACCCTCCTCAT
AGCAGTGGGGCTATTCCTGCTAATGAGAAAACTTCGAGAAAAGCGGCAGACAGAGGGCACCTAC
CGGCCCAGCAGTGAGGAGCAGTTTTCCCACGCAGCAGCTGAGGCCCGGGCCCCCCAGGACTCCA
AGGAGCCAGTGCGGGGCTGCCTGCCCATCTAGCTCCTCCCCTCCTTCCCTGTCATCCATCTTCC
CTTCCTGGCTGTGTGACCTTGTGGAAGGCTTGGGCAGTCAGACTCATACAATACTCAATAGAAG
GGGAGAGAGTTCTTCAGAGACCTTGACTTTGAGGGCAAGCGAGGATGGGGCTACTCACTTTTTA
TATATTTATATGAAATTGATAGGTACAATAAAGGTTTCTTGTTTTTGTTTTTTTA

hide sequence

RefSeq Acc Id:

XM_017596317 ⟹ XP_017451806

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	9	1,987,658 - 1,990,855 (+)	NCBI
mRatBN7.2	9	1,900,676 - 1,903,860 (+)	NCBI
Rnor_6.0	9	9,982,529 - 9,985,691 (-)	NCBI

Sequence:

show sequence

AGCGGGCGGGGCGGGTGGGATCTGGAGCGACCGGGTGAAGGACAGCGACTCGGGGTTCCAGCTG
GGAACCCGGGATTGGAAACCTGAGCGAAGTCCCTCTCTGACGCCTGGGTCAGGTCCTGGGTCGC
AGGTGCCCTCCTCGACCCAAGATGCGGTAGGAATTGGAGCCCTGGGGAAGTCCTGTCCTTGGCG
CCACCAACTCGTCGCCCAAGCTCATGGCGACCCCAGGCCTGGGGCTGCTCTTGGCGTTTGGCTT
GCCGATGCTGCCCTCCGGCTGGAGCCAAGAAACACCAGACTCTTTCACAAATAGCACAACTCAA
CCCCCAGATGGCGGCGGGTCCAACGGGGGCTTGTCCTCAGAGGCCATCGTGGCCATCACTGTGG
TCTTTTCCATTCTGGGAACCCTCCTCATAGCAGTGGGGCTATTCCTGCTAATGAGAAAACTTCG
AGAAAAGCGGCAGACAGAGGGCACCTACCGGCCCAGCAGTGAGGAGCAGTTTTCCCACGCAGCA
GCTGAGGCCCGGGCCCCCCAGGACTCCAAGGAGCCAGTGCGGGGCTGCCTGCCCATCTAGCTCC
TCCCCTCCTTCCCTGTCATCCATCTTCCCTTCCTGGCTGTGTGACCTTGTGGAAGGCTTGGGCA
GTCAGACTCATACAATACTCAATAGAAGGGGAGAGAGTTCTTCAGAGACCTTGACTTTGAGGGC
AAGCGAGGATGGGGCTACTCACTTTTTATATATTTATATGAAATTGATAGGTACAATAAAGGTT
TCTTGTTTTTGTTTTTTTA

hide sequence

RefSeq Acc Id:

XR_010054571

Type:

NON-CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	9	1,985,504 - 1,990,756 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_001020832	(Get FASTA)	NCBI Sequence Viewer
	NP_001418818	(Get FASTA)	NCBI Sequence Viewer
	NP_001418821	(Get FASTA)	NCBI Sequence Viewer
	NP_001418823	(Get FASTA)	NCBI Sequence Viewer
	NP_001418825	(Get FASTA)	NCBI Sequence Viewer
	XP_006244365	(Get FASTA)	NCBI Sequence Viewer
	XP_017451806	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH97382	(Get FASTA)	NCBI Sequence Viewer
	EDL83582	(Get FASTA)	NCBI Sequence Viewer
	EDL83583	(Get FASTA)	NCBI Sequence Viewer
	EDL83584	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000078595
	ENSRNOP00000078595.1
	ENSRNOP00000112488
	ENSRNOP00000112488.1

RefSeq Acc Id:	NP_001020832 ⟸ NM_001025661
- Peptide Label:	precursor
- UniProtKB:	Q4V8I0 (UniProtKB/TrEMBL)
- Sequence:	show sequence MATPGLGLLLAFGLPMLPSGWSQETPDSFTNSTTQPPDGGGSNGGLSSEAIVAITVVFSILGTL LIAVGLFLLMRKLREKRQTEGTYRPSSEEQVGARAPPPPNLKLPPEERLI hide sequence

RefSeq Acc Id:	XP_006244365 ⟸ XM_006244303
- Peptide Label:	isoform X1
- UniProtKB:	A0A0G2JY65 (UniProtKB/TrEMBL), A6KQS4 (UniProtKB/TrEMBL)
- Sequence:	show sequence MATPGLGLLLAFGLPMLPSGWSQETPDSFTNSTTQPPDGGGSNGGLSSEAIVAITVVFSILGTL LIAVGLFLLMRKLREKRQTEGTYRPSSEEQFSHAAAEARAPQDSKEPVRGCLPI hide sequence

RefSeq Acc Id:	XP_017451806 ⟸ XM_017596317
- Peptide Label:	isoform X1
- Sequence:	show sequence MATPGLGLLLAFGLPMLPSGWSQETPDSFTNSTTQPPDGGGSNGGLSSEAIVAITVVFSILGTL LIAVGLFLLMRKLREKRQTEGTYRPSSEEQFSHAAAEARAPQDSKEPVRGCLPI hide sequence

Ensembl Acc Id:

ENSRNOP00000070535 ⟸ ENSRNOT00000080856

Ensembl Acc Id:

ENSRNOP00000064452 ⟸ ENSRNOT00000071780

Ensembl Acc Id:

ENSRNOP00000078595 ⟸ ENSRNOT00000119595

Ensembl Acc Id:

ENSRNOP00000112488 ⟸ ENSRNOT00000172872

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-A0A0G2JY65-F1-model_v2	AlphaFold	A0A0G2JY65	1-118	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13696445

Promoter ID:

EPDNEW_R6965

Type:

multiple initiation site

Name:

Crb3_1

Description:

crumbs 3, cell polarity complex component

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	9	9,985,413 - 9,985,473	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1565035	AgrOrtholog
BioCyc Gene	G2FUF-28492	BioCyc
Ensembl Genes	ENSRNOG00000047322	Ensembl
	ENSRNOG00000070099	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000119595	ENTREZGENE
	ENSRNOT00000119595.2	UniProtKB/TrEMBL
	ENSRNOT00000172872	ENTREZGENE
	ENSRNOT00000172872.1	UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:7446098	IMAGE-MGC_LOAD
KEGG Report	rno:301112	UniProtKB/TrEMBL
MGC_CLONE	MGC:114421	IMAGE-MGC_LOAD
NCBI Gene	301112	ENTREZGENE
PhenoGen	Crb3	PhenoGen
RatGTEx	ENSRNOG00000047322	RatGTEx
	ENSRNOG00000070099	RatGTEx
UniProt	A0A0G2JY65	ENTREZGENE, UniProtKB/TrEMBL
	A0ABK0M3A2_RAT	UniProtKB/TrEMBL
	A6KQS4	ENTREZGENE, UniProtKB/TrEMBL
	Q4V8I0	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2018-12-04	Crb3	crumbs cell polarity complex component 3	Crb3	crumbs 3, cell polarity complex component	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2016-03-01	Crb3	crumbs 3, cell polarity complex component	Crb3	crumbs family member 3	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2014-02-13	Crb3	crumbs family member 3	Crb3	crumbs homolog 3 (Drosophila)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2006-03-30	Crb3	crumbs homolog 3 (Drosophila)	LOC301112	similar to Crumbs homolog 3	Symbol and Name updated	1299863	APPROVED
2006-02-09	LOC301112	similar to Crumbs homolog 3			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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