Msr1 (macrophage scavenger receptor 1) - Rat Genome Database

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Gene: Msr1 (macrophage scavenger receptor 1) Rattus norvegicus
Analyze
Symbol: Msr1
Name: macrophage scavenger receptor 1
RGD ID: 1564316
Description: Predicted to enable amyloid-beta binding activity; cargo receptor activity; and low-density lipoprotein particle binding activity. Predicted to be involved in several processes, including endocytosis; positive regulation of cholesterol storage; and positive regulation of macrophage derived foam cell differentiation. Predicted to act upstream of or within establishment of localization in cell and lipoprotein transport. Predicted to be located in plasma membrane. Human ortholog(s) of this gene implicated in Barrett's esophagus; arteriosclerosis; and prostate cancer. Orthologous to human MSR1 (macrophage scavenger receptor 1); PARTICIPATES IN phagocytosis pathway; INTERACTS WITH 1,2-dimethylhydrazine; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC498638; macrophage scavenger receptor types I and II; RGD1564316; similar to scavenger receptor type A SR-A
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81659,421,250 - 59,507,070 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1659,421,057 - 59,507,070 (+)EnsemblGRCr8
mRatBN7.21652,717,775 - 52,803,602 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1652,717,732 - 52,799,676 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1658,047,955 - 58,113,146 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01661,453,017 - 61,518,269 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01656,681,953 - 56,747,156 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01656,817,714 - 56,900,025 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1656,813,791 - 56,900,052 (-)Ensemblrn6Rnor6.0
Rnor_5.01656,516,982 - 56,597,180 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41656,278,223 - 56,345,472 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1650,621,592 - 50,686,791 (+)NCBICelera
Cytogenetic Map16q12.1NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(R)-lipoic acid  (ISO)
1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene  (ISO)
1,2-dimethylhydrazine  (EXP,ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,4'-trichlorobiphenyl  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
acetamide  (EXP)
acrylamide  (ISO)
aldehydo-D-glucose  (ISO)
antirheumatic drug  (ISO)
apocynin  (ISO)
aristolochic acid A  (ISO)
arsenous acid  (ISO)
atorvastatin calcium  (ISO)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
bisdemethoxycurcumin  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
Calcimycin  (ISO)
calcitriol  (ISO)
carbon nanotube  (ISO)
carmustine  (ISO)
cholesterol  (ISO)
choline  (ISO)
chrysene  (ISO)
curcumin  (ISO)
cycloheximide  (ISO)
D-glucose  (ISO)
demethoxycurcumin  (ISO)
desferrioxamine B  (ISO)
diarsenic trioxide  (ISO)
dibenz[a,h]anthracene  (ISO)
dioxygen  (EXP,ISO)
disodium selenite  (ISO)
epoxiconazole  (ISO)
ethanol  (ISO)
ethyl methanesulfonate  (ISO)
folic acid  (ISO)
formaldehyde  (ISO)
fructose  (ISO)
furosemide  (EXP)
glucose  (ISO)
glyphosate  (EXP,ISO)
hydrogen peroxide  (ISO)
hydroxyl  (ISO)
irinotecan  (EXP)
isoprenaline  (ISO)
L-methionine  (ISO)
lidocaine  (EXP)
lipoic acid  (ISO)
lipopolysaccharide  (ISO)
LLY-507  (ISO)
mercury atom  (ISO)
mercury dichloride  (ISO)
mercury(0)  (ISO)
methyl methanesulfonate  (ISO)
miquelianin  (ISO)
Monobutylphthalate  (EXP)
okadaic acid  (ISO)
ozone  (ISO)
paracetamol  (ISO)
paraquat  (EXP)
PCB138  (ISO)
phenylarsine oxide  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
procyanidin B3  (ISO)
quartz  (EXP)
resveratrol  (ISO)
rotenone  (ISO)
silicon dioxide  (ISO)
sirolimus  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium benzoate  (ISO)
tamibarotene  (ISO)
Tanshinone I  (ISO)
TEMPO  (ISO)
tetrachloromethane  (ISO)
tetraphene  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
tremolite asbestos  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
valproic acid  (ISO)
zinc oxide  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
membrane  (IEA)
plasma membrane  (IBA,ISO)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Scavenger receptor-A-targeted leukocyte depletion inhibits peritoneal ovarian tumor progression. Bak SP, etal., Cancer Res. 2007 May 15;67(10):4783-9.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Adeno-associated virus-mediated gene transfer of a secreted decoy human macrophage scavenger receptor reduces atherosclerotic lesion formation in LDL receptor knockout mice. Jalkanen J, etal., Mol Ther. 2003 Dec;8(6):903-10.
4. Potential effects of microglial activation induced by ginsenoside Rg3 in rat primary culture: enhancement of type A Macrophage Scavenger Receptor expression. Joo SS and Lee DI, Arch Pharm Res. 2005 Oct;28(10):1164-9.
5. Elucidating the molecular physiopathology of acute respiratory distress syndrome in severe acute respiratory syndrome patients. Kong SL, etal., Virus Res. 2009 Nov;145(2):260-9. Epub 2009 Jul 25.
6. Pulmonary surfactant protein A augments the phagocytosis of Streptococcus pneumoniae by alveolar macrophages through a casein kinase 2-dependent increase of cell surface localization of scavenger receptor A. Kuronuma K, etal., J Biol Chem. 2004 May 14;279(20):21421-30. Epub 2004 Mar 1.
7. A genome-wide association study of breast and prostate cancer in the NHLBI's Framingham Heart Study. Murabito JM, etal., BMC Med Genet. 2007 Sep 19;8 Suppl 1:S6.
8. Class A macrophage scavenger receptor gene expression levels in peripheral blood mononuclear cells specifically increase in patients with acute coronary syndrome. Nakayama M, etal., Atherosclerosis. 2008 Jun;198(2):426-33. Epub 2007 Oct 22.
9. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
10. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
11. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
12. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
13. Comprehensive gene review and curation RGD comprehensive gene curation
14. Requirement of JNK2 for scavenger receptor A-mediated foam cell formation in atherogenesis. Ricci R, etal., Science. 2004 Nov 26;306(5701):1558-61.
15. A role for macrophage scavenger receptors in atherosclerosis and susceptibility to infection. Suzuki H, etal., Nature. 1997 Mar 20;386(6622):292-6.
16. Targeted deletion of class A macrophage scavenger receptor increases the risk of cardiac rupture after experimental myocardial infarction. Tsujita K, etal., Circulation. 2007 Apr 10;115(14):1904-11. Epub 2007 Mar 26.
Additional References at PubMed
PMID:11240025   PMID:12376530   PMID:17148552   PMID:17237231   PMID:21765240   PMID:22438044   PMID:23823020   PMID:24718459  


Genomics

Comparative Map Data
Msr1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81659,421,250 - 59,507,070 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1659,421,057 - 59,507,070 (+)EnsemblGRCr8
mRatBN7.21652,717,775 - 52,803,602 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1652,717,732 - 52,799,676 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1658,047,955 - 58,113,146 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01661,453,017 - 61,518,269 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01656,681,953 - 56,747,156 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01656,817,714 - 56,900,025 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1656,813,791 - 56,900,052 (-)Ensemblrn6Rnor6.0
Rnor_5.01656,516,982 - 56,597,180 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41656,278,223 - 56,345,472 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1650,621,592 - 50,686,791 (+)NCBICelera
Cytogenetic Map16q12.1NCBI
MSR1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38816,107,881 - 16,192,651 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl816,107,878 - 16,567,490 (-)Ensemblhg38GRCh38
GRCh37815,965,390 - 16,050,160 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36816,009,758 - 16,094,671 (-)NCBIBuild 36Build 36hg18NCBI36
Build 34816,009,760 - 16,094,595NCBI
Celera814,929,936 - 15,014,828 (-)NCBICelera
Cytogenetic Map8p22NCBI
HuRef814,509,923 - 14,594,638 (-)NCBIHuRef
CHM1_1816,167,312 - 16,251,899 (-)NCBICHM1_1
T2T-CHM13v2.0816,374,329 - 16,459,913 (-)NCBIT2T-CHM13v2.0
Msr1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39839,996,284 - 40,095,790 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl840,034,726 - 40,095,714 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38839,543,232 - 39,642,750 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl839,581,685 - 39,642,673 (-)Ensemblmm10GRCm38
MGSCv37840,667,054 - 40,728,032 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36841,102,269 - 41,141,495 (-)NCBIMGSCv36mm8
Celera842,254,529 - 42,315,500 (-)NCBICelera
Cytogenetic Map8A4NCBI
cM Map823.89NCBI
Msr1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554631,197,022 - 1,264,765 (+)Ensembl
ChiLan1.0NW_0049554631,197,086 - 1,263,943 (+)NCBIChiLan1.0ChiLan1.0
MSR1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2734,577,677 - 34,663,873 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1810,315,632 - 10,401,269 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0815,335,795 - 15,421,472 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1812,091,543 - 12,175,927 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl812,088,873 - 12,175,927 (-)EnsemblpanPan2panpan1.1
MSR1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11639,434,948 - 39,513,727 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1639,436,753 - 39,527,438 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1639,918,454 - 39,996,751 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01641,487,019 - 41,565,417 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1641,487,570 - 41,565,264 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11639,583,887 - 39,662,157 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01640,129,035 - 40,207,399 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01640,253,347 - 40,331,889 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Msr1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494339,750,600 - 39,814,340 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365735,328,526 - 5,388,901 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365735,345,282 - 5,391,946 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MSR1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl173,859,692 - 3,939,726 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1173,859,903 - 3,939,612 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2174,110,409 - 4,191,629 (-)NCBISscrofa10.2Sscrofa10.2susScr3
MSR1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1814,221,389 - 14,305,059 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl814,220,529 - 14,304,946 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366605228,000,740 - 28,084,945 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Msr1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624839694,032 - 770,254 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_004624839694,149 - 769,322 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Msr1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11347,758,008 - 47,831,006 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Msr1
768 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:22
Count of miRNA genes:22
Interacting mature miRNAs:22
Transcripts:ENSRNOT00000017339
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2300163Bmd64Bone mineral density QTL 645.30.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)164445512389455123Rat
70215Niddm29Non-insulin dependent diabetes mellitus QTL 293.54blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)163692878281928782Rat
1578768Stresp22Stress response QTL 222.8thymus mass (VT:0004954)thymus wet weight (CMO:0000855)164199206486992064Rat
737826Alc11Alcohol consumption QTL 113.2consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)16423421266955197Rat
2302057Pia29Pristane induced arthritis QTL 293.60.001blood autoantibody amount (VT:0003725)serum immunoglobulin M-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002111)162846870173468701Rat
7205510Activ5Activity QTL 53.780.00028locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)164909919691442908Rat
1357403Slep4Serum leptin concentration QTL 43.91blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)163236104377361043Rat
8694453Bw172Body weight QTL 1728.330.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)163105803976058039Rat
7411648Foco22Food consumption QTL 22150.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)165942871491442908Rat
1298529Arunc1Aerobic running capacity QTL 14exercise endurance trait (VT:0002332)longest distance run on treadmill (CMO:0001406)163439829479398294Rat
2312663Slep9Serum leptin concentration QTL 90.001blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)1683908666195506Rat
2312660Bw95Body weight QTL 950.05inguinal fat pad mass (VT:0010424)inguinal fat pad weight to body weight ratio (CMO:0001253)1683908666195506Rat
6903294Stl30Serum triglyceride level QTL 302.60.0013blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)163188527176885271Rat
2293690Bss45Bone structure and strength QTL 455.130.0001lumbar vertebra morphology trait (VT:0010494)lumbar vertebra cortical cross-sectional area (CMO:0001690)164445512389455123Rat
8694364Abfw7Abdominal fat weight QTL 712.220.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)165942871491442908Rat
2312666Insul16Insulin level QTL 160.01blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1683908666195506Rat
8694429Bw164Body weight QTL 16450.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)165942871491442908Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor diameter (CMO:0001889)161773081872536785Rat
2301406Kidm39Kidney mass QTL 390.002kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)161590580260905802Rat
2312669Stl23Serum triglyceride level QTL 230.01blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)1683908666195506Rat

Markers in Region
L04275  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81659,465,074 - 59,465,216 (+)Marker Load Pipeline
mRatBN7.21652,761,611 - 52,761,754 (-)MAPPERmRatBN7.2
Rnor_6.01656,855,484 - 56,855,626NCBIRnor6.0
Rnor_5.01656,554,428 - 56,554,570UniSTSRnor5.0
RGSC_v3.41656,307,067 - 56,307,209UniSTSRGSC3.4
Celera1650,649,092 - 50,649,234UniSTS
Cytogenetic Map16q12.1UniSTS
RH127715  
Rat AssemblyChrPosition (strand)SourceJBrowse
Celera1650,678,418 - 50,678,630UniSTS
Celera5164,343,501 - 164,343,713UniSTS
Cytogenetic Map5q36UniSTS
Cytogenetic Map16q12.1UniSTS
AA900898  
Rat AssemblyChrPosition (strand)SourceJBrowse
Celera5164,342,363 - 164,342,551UniSTS
Celera1650,677,236 - 50,677,425UniSTS
RH 3.4 Map8849.9UniSTS
Cytogenetic Map1p11UniSTS
Cytogenetic Map16q12.1UniSTS
Cytogenetic Map5q36UniSTS
UniSTS:496680  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_5.02176,377,830 - 176,378,105NCBIRnor5.0
Rnor_5.03151,876,035 - 151,876,320NCBIRnor5.0
Rnor_5.01656,527,453 - 56,527,738NCBIRnor5.0
RGSC_v3.4132,051,429 - 32,051,703UniSTSRGSC3.4
RGSC_v3.41656,334,152 - 56,334,436UniSTSRGSC3.4
Celera1650,676,178 - 50,676,462UniSTS
Cytogenetic Map16q12.1UniSTS
Cytogenetic Map5q36UniSTS
Cytogenetic Map1p11UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 11 61 158 91 90 59 70 59 6 324 163 11 137 78 92 31 14 14

Sequence


Ensembl Acc Id: ENSRNOT00000017339   ⟹   ENSRNOP00000017339
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1659,421,295 - 59,494,569 (+)Ensembl
mRatBN7.2 Ensembl1652,717,732 - 52,799,676 (+)Ensembl
Rnor_6.0 Ensembl1656,813,791 - 56,900,052 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000147935   ⟹   ENSRNOP00000104015
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1659,421,057 - 59,507,070 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000172903   ⟹   ENSRNOP00000105453
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1659,437,518 - 59,468,304 (+)Ensembl
RefSeq Acc Id: NM_001191939   ⟹   NP_001178868
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81659,421,358 - 59,507,070 (+)NCBI
mRatBN7.21652,717,886 - 52,803,602 (+)NCBI
Rnor_6.01656,818,085 - 56,885,064 (-)NCBI
Rnor_5.01656,516,982 - 56,597,180 (-)NCBI
Celera1650,621,592 - 50,686,791 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001411777   ⟹   NP_001398706
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81659,421,358 - 59,468,304 (+)NCBI
mRatBN7.21652,717,886 - 52,764,842 (+)NCBI
RefSeq Acc Id: XM_039094773   ⟹   XP_038950701
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81659,421,250 - 59,495,282 (+)NCBI
mRatBN7.21652,717,775 - 52,791,318 (+)NCBI
RefSeq Acc Id: NP_001178868   ⟸   NM_001191939
- Peptide Label: isoform 1
- UniProtKB: D3ZDS2 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000017339   ⟸   ENSRNOT00000017339
RefSeq Acc Id: XP_038950701   ⟸   XM_039094773
- Peptide Label: isoform X1
- UniProtKB: D3ZDS2 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001398706   ⟸   NM_001411777
- Peptide Label: isoform 2
Ensembl Acc Id: ENSRNOP00000104015   ⟸   ENSRNOT00000147935
Ensembl Acc Id: ENSRNOP00000105453   ⟸   ENSRNOT00000172903

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZDS2-F1-model_v2 AlphaFold D3ZDS2 1-509 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1564316 AgrOrtholog
BioCyc Gene G2FUF-11236 BioCyc
Ensembl Genes ENSRNOG00000012779 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000017339 ENTREZGENE
  ENSRNOT00000017339.9 UniProtKB/TrEMBL
  ENSRNOT00000147935 ENTREZGENE
  ENSRNOT00000147935.1 UniProtKB/TrEMBL
  ENSRNOT00000172903 ENTREZGENE
  ENSRNOT00000172903.1 UniProtKB/TrEMBL
Gene3D-CATH 3.10.250.10 UniProtKB/TrEMBL
InterPro Collagen UniProtKB/TrEMBL
  Macro_scav_rcpt UniProtKB/TrEMBL
  SRCR-like_dom_sf UniProtKB/TrEMBL
  Srcr_rcpt UniProtKB/TrEMBL
NCBI Gene 498638 ENTREZGENE
PANTHER MACROPHAGE SCAVENGER RECEPTOR TYPES I AND II UniProtKB/TrEMBL
  SRCR DOMAIN-CONTAINING PROTEIN UniProtKB/TrEMBL
Pfam Collagen UniProtKB/TrEMBL
  Macscav_rec UniProtKB/TrEMBL
  SRCR UniProtKB/TrEMBL
PhenoGen Msr1 PhenoGen
PRINTS MACSCAVRCPTR UniProtKB/TrEMBL
  SPERACTRCPTR UniProtKB/TrEMBL
PROSITE SRCR_1 UniProtKB/TrEMBL
  SRCR_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000012779 RatGTEx
SMART SM00202 UniProtKB/TrEMBL
Superfamily-SCOP Srcr_receptor UniProtKB/TrEMBL
UniProt A0ABK0LIB0_RAT UniProtKB/TrEMBL
  A0ABK0LQX4_RAT UniProtKB/TrEMBL
  D3ZDS2 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-03-06 Msr1  macrophage scavenger receptor 1  RGD1564316_predicted  similar to scavenger receptor type A SR-A (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-07 RGD1564316_predicted  similar to scavenger receptor type A SR-A (predicted)  LOC498638  similar to scavenger receptor type A SR-A  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC498638  similar to scavenger receptor type A SR-A      Symbol and Name status set to provisional 70820 PROVISIONAL