Spg11 (SPG11 vesicle trafficking associated, spatacsin) - Rat Genome Database

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Gene: Spg11 (SPG11 vesicle trafficking associated, spatacsin) Rattus norvegicus
Analyze
Symbol: Spg11
Name: SPG11 vesicle trafficking associated, spatacsin
RGD ID: 1562529
Description: Predicted to enable protein kinase binding activity. Predicted to be involved in several processes, including axo-dendritic transport; axonogenesis; and synaptic vesicle transport. Predicted to act upstream of or within several processes, including axonogenesis; cholesterol efflux; and vacuole organization. Predicted to be located in cytoplasmic vesicle and cytosol. Predicted to be active in several cellular components, including axon; dendrite; and endoplasmic reticulum. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease axonal type 2X; amyotrophic lateral sclerosis type 5; and hereditary spastic paraplegia 11. Orthologous to human SPG11 (SPG11 vesicle trafficking associated, spatacsin); INTERACTS WITH (+)-schisandrin B; bisphenol A; gentamycin.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC311372; RGD1562529; similar to hypothetical protein FLJ21439; spastic paraplegia 11 (autosomal recessive); spatacsin; SPG11, spatacsin vesicle trafficking associated
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83129,453,118 - 129,526,469 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl3129,461,477 - 129,526,742 (-)EnsemblGRCr8
mRatBN7.23109,007,658 - 109,072,904 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3109,008,135 - 109,072,911 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx3112,682,104 - 112,746,807 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03121,277,640 - 121,342,332 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03118,938,014 - 119,002,708 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.03113,999,600 - 114,064,438 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3113,999,719 - 114,065,170 (-)Ensemblrn6Rnor6.0
Rnor_5.03120,539,553 - 120,604,712 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.43108,839,055 - 108,905,008 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera3107,906,940 - 107,971,094 (-)NCBICelera
Cytogenetic Map3q35NCBI
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
axon  (IBA,IEA,ISO)
cytoplasm  (IBA,IEA,ISO)
cytoplasmic vesicle  (IEA,ISO)
cytosol  (IEA,ISO)
dendrite  (IBA,IEA,ISO)
endoplasmic reticulum  (IEA,ISO)
late endosome  (IEA,ISO)
lysosome  (IEA,ISO)
nucleolus  (IEA,ISO)
plasma membrane  (IEA,ISO)
synapse  (IBA,IEA,ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Cellular distribution and subcellular localization of spatacsin and spastizin, two proteins involved in hereditary spastic paraplegia. Murmu RP, etal., Mol Cell Neurosci. 2011 Jul;47(3):191-202. doi: 10.1016/j.mcn.2011.04.004. Epub 2011 Apr 27.
3. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
4. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:17322883   PMID:17897319   PMID:23376485   PMID:24794856   PMID:26284655  


Genomics

Comparative Map Data
Spg11
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83129,453,118 - 129,526,469 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl3129,461,477 - 129,526,742 (-)EnsemblGRCr8
mRatBN7.23109,007,658 - 109,072,904 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3109,008,135 - 109,072,911 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx3112,682,104 - 112,746,807 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03121,277,640 - 121,342,332 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03118,938,014 - 119,002,708 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.03113,999,600 - 114,064,438 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3113,999,719 - 114,065,170 (-)Ensemblrn6Rnor6.0
Rnor_5.03120,539,553 - 120,604,712 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.43108,839,055 - 108,905,008 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera3107,906,940 - 107,971,094 (-)NCBICelera
Cytogenetic Map3q35NCBI
SPG11
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381544,562,696 - 44,663,662 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1544,554,818 - 44,663,688 (-)Ensemblhg38GRCh38
GRCh371544,854,894 - 44,955,860 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361542,642,186 - 42,743,168 (-)NCBIBuild 36Build 36hg18NCBI36
Celera1521,744,647 - 21,845,628 (-)NCBICelera
Cytogenetic Map15q21.1NCBI
HuRef1521,678,554 - 21,779,155 (-)NCBIHuRef
CHM1_11544,972,998 - 45,073,973 (-)NCBICHM1_1
T2T-CHM13v2.01542,370,662 - 42,471,634 (-)NCBIT2T-CHM13v2.0
Spg11
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392121,884,001 - 121,949,915 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2121,884,001 - 121,948,867 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm382122,053,526 - 122,119,434 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2122,053,520 - 122,118,386 (-)Ensemblmm10GRCm38
MGSCv372121,879,262 - 121,944,122 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
Celera2155,871,768 - 155,874,475 (-)NCBICelera
Cytogenetic Map2E5NCBI
cM Map260.5NCBI
Spg11
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541611,086,176 - 11,168,332 (-)Ensembl
ChiLan1.0NW_00495541611,084,448 - 11,168,478 (-)NCBIChiLan1.0ChiLan1.0
SPG11
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21633,811,472 - 33,912,784 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11537,974,171 - 38,076,040 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01523,519,311 - 23,620,532 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11541,688,081 - 41,788,616 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1541,688,081 - 41,788,616 (-)EnsemblpanPan2panpan1.1
SPG11
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13011,233,709 - 11,305,454 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3011,233,718 - 11,305,485 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha3011,290,282 - 11,362,060 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.03011,370,230 - 11,442,064 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3011,370,232 - 11,442,889 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13011,277,612 - 11,349,334 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03011,400,030 - 11,471,816 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03011,519,270 - 11,591,057 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Spg11
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864089,693,796 - 89,770,733 (-)NCBIHiC_Itri_2
SpeTri2.0NW_0049364717,540,647 - 7,618,783 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SPG11
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1126,902,186 - 127,003,397 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1 Ensembl1126,890,892 - 126,899,991 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11126,890,464 - 126,998,014 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
SPG11
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12638,386,000 - 38,482,236 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666048102,561,369 - 102,665,640 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Spg11
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462480411,569,150 - 11,670,373 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462480411,569,024 - 11,672,037 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Spg11
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v15100,164,257 - 100,230,360 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Spg11
390 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:24
Count of miRNA genes:24
Interacting mature miRNAs:24
Transcripts:ENSRNOT00000022875
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2301414Kidm37Kidney mass QTL 370.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)396509147141509147Rat
1582238Bw68Body weight QTL 683.20.0064body mass (VT:0001259)body weight (CMO:0000012)373592512136118980Rat
2302373Gluco39Glucose level QTL 395.01blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)3129154923182114333Rat
1582239Epfw1Epididymal fat weight QTL 14.50.0006epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)373592512136118980Rat
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)351581665184004958Rat
2292591Esta4Estrogen-induced thymic atrophy QTL 4thymus mass (VT:0004954)thymus wet weight (CMO:0000855)367641776167835660Rat
1358362Srcrt2Stress Responsive Cort QTL 22.78blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)358601291153936591Rat
1582216Bw65Body weight QTL 656.3body mass (VT:0001259)body weight (CMO:0000012)3122654702136118980Rat
737818Hcar12Hepatocarcinoma resistance QTL 122.6liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)349872657138829559Rat
1582218Bw74Body weight QTL 743.90.0021body mass (VT:0001259)body weight (CMO:0000012)373592512136118980Rat
1582219Bw63Body weight QTL 633.80.001body mass (VT:0001259)body weight (CMO:0000012)3116582412136118980Rat
1582221Kidm30Kidney mass QTL 303.50.0008kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)385062224136118980Rat
1582210Bw71Body weight QTL 713.30.0012body mass (VT:0001259)body weight (CMO:0000012)385062224136118980Rat
7387306Bw124Body weight QTL 1243.20.0003body mass (VT:0001259)body weight (CMO:0000012)3104545086149545086Rat
1300111Rf12Renal function QTL 123.78renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)381425008141509147Rat
724523Tsu1Thymus enlargement suppressive QTL 13.84thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)370845569136091483Rat
1600376Arunc5Aerobic running capacity QTL 50.21exercise endurance trait (VT:0002332)longest distance run on treadmill (CMO:0001406)393829559138829559Rat
8694437Bw167Body weight QTL 16722.460.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)3112250810157250810Rat
2302273Gluco35Glucose level QTL 355.30.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)3101255536134750886Rat
8662816Vetf4Vascular elastic tissue fragility QTL 44renal artery integrity trait (VT:0010642)number of ruptures of the internal elastic lamina of the renal arteries (CMO:0002563)379649560177741895Rat
2292613Ept16Estrogen-induced pituitary tumorigenesis QTL 168.3pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)367641995130815812Rat
1581503Cm58Cardiac mass QTL 582.70.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)396509147141509147Rat
1354611Despr2Despair related QTL 23.030.0028locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)3117537367162537367Rat
2303620Vencon4Ventilatory control QTL 43.9respiration trait (VT:0001943)tidal volume (CMO:0000222)3125116475170116475Rat
631649Bp123Blood pressure QTL 1233.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3110225882155225882Rat
12879848Bw181Body weght QTL 1810.015body mass (VT:0001259)body weight (CMO:0000012)390755164141509147Rat
5686842Rf59Renal function QTL 59urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)3122395989167395989Rat
1358885Bp251Blood pressure QTL 2513.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)31141509147Rat
1581546Pur13Proteinuria QTL 132.930.0335urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)398651826167012663Rat
631665Bw8Body weight QTL 85.5body mass (VT:0001259)body weight (CMO:0000012)3125814931139636791Rat
1331758Bp207Blood pressure QTL 2072.848arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)3110634702155634702Rat
1358888Bp264Blood pressure QTL 2644.43arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)35675975141509147Rat
1358186Ept2Estrogen-induced pituitary tumorigenesis QTL 28.3pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)367641995130815812Rat
724532Cm17Cardiac mass QTL 172heart mass (VT:0007028)calculated heart weight (CMO:0000073)3116188400161188400Rat

Markers in Region
D3Got231  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23109,021,432 - 109,021,610 (+)MAPPERmRatBN7.2
Rnor_6.03114,013,021 - 114,013,198NCBIRnor6.0
Rnor_5.03120,552,964 - 120,553,141UniSTSRnor5.0
RGSC_v3.43108,852,357 - 108,852,534UniSTSRGSC3.4
Celera3107,920,192 - 107,920,369UniSTS
Cytogenetic Map3q35UniSTS
RH133059  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23109,007,639 - 109,007,835 (+)MAPPERmRatBN7.2
Rnor_6.03113,999,224 - 113,999,419NCBIRnor6.0
Rnor_5.03120,539,197 - 120,539,392UniSTSRnor5.0
RGSC_v3.43108,838,560 - 108,838,755UniSTSRGSC3.4
Celera3107,906,445 - 107,906,640UniSTS
RH 3.4 Map3954.3UniSTS
Cytogenetic Map3q35UniSTS
AA946404  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23109,008,188 - 109,008,383 (+)MAPPERmRatBN7.2
Rnor_6.03113,999,773 - 113,999,967NCBIRnor6.0
Rnor_5.03120,539,746 - 120,539,940UniSTSRnor5.0
RGSC_v3.43108,839,109 - 108,839,303UniSTSRGSC3.4
Celera3107,906,994 - 107,907,188UniSTS
RH 3.4 Map3954.1UniSTS
Cytogenetic Map3q35UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
23 13 82 210 91 90 59 154 59 6 480 279 22 188 111 124 31 31 31

Sequence


Ensembl Acc Id: ENSRNOT00000022875   ⟹   ENSRNOP00000022875
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl3109,008,135 - 109,072,911 (-)Ensembl
Rnor_6.0 Ensembl3113,999,719 - 114,064,389 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000080253   ⟹   ENSRNOP00000071131
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl3129,461,477 - 129,526,742 (-)Ensembl
mRatBN7.2 Ensembl3109,008,135 - 109,072,911 (-)Ensembl
Rnor_6.0 Ensembl3113,999,719 - 114,065,170 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000097776   ⟹   ENSRNOP00000081282
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl3129,461,477 - 129,526,444 (-)Ensembl
mRatBN7.2 Ensembl3109,008,135 - 109,072,911 (-)Ensembl
RefSeq Acc Id: NM_001415924   ⟹   NP_001402853
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83129,461,477 - 129,526,444 (-)NCBI
mRatBN7.23109,007,865 - 109,072,851 (-)NCBI
RefSeq Acc Id: XM_017591740   ⟹   XP_017447229
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83129,453,118 - 129,526,467 (-)NCBI
mRatBN7.23109,007,658 - 109,072,886 (-)NCBI
Rnor_6.03113,999,600 - 114,064,438 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039104972   ⟹   XP_038960900
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83129,453,118 - 129,502,312 (-)NCBI
mRatBN7.23109,007,658 - 109,048,717 (-)NCBI
RefSeq Acc Id: XM_039104973   ⟹   XP_038960901
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83129,453,118 - 129,496,343 (-)NCBI
mRatBN7.23109,007,658 - 109,042,740 (-)NCBI
RefSeq Acc Id: XR_005501873
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83129,466,506 - 129,526,469 (-)NCBI
mRatBN7.23109,008,230 - 109,072,904 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001402853 (Get FASTA)   NCBI Sequence Viewer  
  XP_017447229 (Get FASTA)   NCBI Sequence Viewer  
  XP_038960900 (Get FASTA)   NCBI Sequence Viewer  
  XP_038960901 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL80015 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000071131
  ENSRNOP00000071131.3
  ENSRNOP00000081282.1
RefSeq Acc Id: XP_017447229   ⟸   XM_017591740
- Peptide Label: isoform X1
- UniProtKB: A0A8I6G5Q3 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000071131   ⟸   ENSRNOT00000080253
Ensembl Acc Id: ENSRNOP00000022875   ⟸   ENSRNOT00000022875
RefSeq Acc Id: XP_038960900   ⟸   XM_039104972
- Peptide Label: isoform X2
- UniProtKB: A6HPR4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038960901   ⟸   XM_039104973
- Peptide Label: isoform X3
- UniProtKB: A6HPR4 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000081282   ⟸   ENSRNOT00000097776
RefSeq Acc Id: NP_001402853   ⟸   NM_001415924
- UniProtKB: A0A8I6G5Q3 (UniProtKB/TrEMBL),   A0A0G2JZP7 (UniProtKB/TrEMBL)
Protein Domains
Spatacsin C-terminal

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0A0G2JZP7-F1-model_v2 AlphaFold A0A0G2JZP7 1-2465 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13692363
Promoter ID:EPDNEW_R2888
Type:initiation region
Name:Spg11_1
Description:SPG11, spatacsin vesicle trafficking associated
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.03114,064,401 - 114,064,461EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1562529 AgrOrtholog
BioCyc Gene G2FUF-48113 BioCyc
Ensembl Genes ENSRNOG00000021954 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000080253 ENTREZGENE
  ENSRNOT00000080253.3 UniProtKB/TrEMBL
  ENSRNOT00000097776.2 UniProtKB/TrEMBL
InterPro Spatacsin UniProtKB/TrEMBL
  Spatacsin_C_dom UniProtKB/TrEMBL
NCBI Gene 311372 ENTREZGENE
PANTHER PTHR13650 UniProtKB/TrEMBL
  SPATACSIN UniProtKB/TrEMBL
Pfam Spatacsin_C UniProtKB/TrEMBL
PhenoGen Spg11 PhenoGen
RatGTEx ENSRNOG00000021954 RatGTEx
UniProt A0A0G2JZP7 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6G5Q3 ENTREZGENE, UniProtKB/TrEMBL
  A6HPR4 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-04-02 Spg11  SPG11 vesicle trafficking associated, spatacsin  Spg11  SPG11, spatacsin vesicle trafficking associated  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2017-02-09 Spg11  SPG11, spatacsin vesicle trafficking associated  Spg11  spastic paraplegia 11 (autosomal recessive)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2010-05-25 Spg11  spastic paraplegia 11 (autosomal recessive)  RGD1562529  similar to hypothetical protein FLJ21439  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 RGD1562529  similar to hypothetical protein FLJ21439   RGD1562529_predicted  similar to hypothetical protein FLJ21439 (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-07 RGD1562529_predicted  similar to hypothetical protein FLJ21439 (predicted)  LOC311372  similar to hypothetical protein FLJ21439  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC311372  similar to hypothetical protein FLJ21439      Symbol and Name status set to provisional 70820 PROVISIONAL