Elavl4 (ELAV like RNA binding protein 4) - Rat Genome Database

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Gene: Elavl4 (ELAV like RNA binding protein 4) Rattus norvegicus
Analyze
Symbol: Elavl4
Name: ELAV like RNA binding protein 4
RGD ID: 1560027
Description: Enables mRNA 3'-UTR binding activity. Involved in several processes, including cellular response to nerve growth factor stimulus; positive regulation of dendrite development; and post-transcriptional regulation of gene expression. Located in several cellular components, including apical dendrite; growth cone; and ribosome. Is active in glutamatergic synapse. Biomarker of hypothyroidism; learning disability; sciatic neuropathy; and status epilepticus. Orthologous to human ELAVL4 (ELAV like RNA binding protein 4); INTERACTS WITH 6-propyl-2-thiouracil; acrylamide; amitrole.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4; ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D); ELAV like neuron-specific RNA binding protein 4; ELAV-like protein 4; hu-antigen D; HuD; LOC298359; paraneoplastic encephalomyelitis antigen HuD; r-HuD; RGD1561943; similar to ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85130,285,418 - 130,429,106 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl5130,285,418 - 130,429,096 (-)EnsemblGRCr8
mRatBN7.25125,056,848 - 125,200,543 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5125,056,848 - 125,200,446 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx5127,668,033 - 127,750,245 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05129,391,090 - 129,473,304 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05129,442,384 - 129,524,600 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.05130,001,387 - 130,144,557 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5130,001,372 - 130,085,838 (-)Ensemblrn6Rnor6.0
Rnor_5.05133,837,537 - 133,979,844 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.45131,672,012 - 131,767,950 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera5123,783,448 - 123,864,325 (-)NCBICelera
Cytogenetic Map5q35NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
apical dendrite  (IDA)
axon  (IEA,ISO)
cytoplasm  (IDA,IEA,ISO)
dendrite  (IDA,IEA,ISO)
glutamatergic synapse  (IDA,IMP)
growth cone  (IDA,IEA)
neuronal cell body  (IDA)
nuclear envelope  (IDA)
perikaryon  (IEA)
postsynapse  (IEA)
ribonucleoprotein complex  (IEA)
ribosome  (IDA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Increased expression and localization of the RNA-binding protein HuD and GAP-43 mRNA to cytoplasmic granules in DRG neurons during nerve regeneration. Anderson KD, etal., Exp Neurol. 2003 Sep;183(1):100-8.
2. Embryonic lethal abnormal vision-like RNA-binding proteins regulate neurite outgrowth and tau expression in PC12 cells. Aranda-Abreu GE, etal., J Neurosci. 1999 Aug 15;19(16):6907-17.
3. Coordinated expression of HuD and GAP-43 in hippocampal dentate granule cells during developmental and adult plasticity. Bolognani F, etal., Neurochem Res. 2007 Dec;32(12):2142-51. Epub 2007 Jun 19.
4. Dendritic localization of the RNA-binding protein HuD in hippocampal neurons: association with polysomes and upregulation during contextual learning. Bolognani F, etal., Neurosci Lett. 2004 Nov 23;371(2-3):152-7.
5. HuD distribution changes in response to heat shock but not neurotrophic stimulation. Burry RW and Smith CL, J Histochem Cytochem. 2006 Oct;54(10):1129-38. Epub 2006 Jun 26.
6. Expression of mRNA for the elav-like neural-specific RNA binding protein, HuD, during nervous system development. Clayton GH, etal., Brain Res Dev Brain Res. 1998 Aug 8;109(2):271-80.
7. Neuronal HuD gene encoding a mRNA stability regulator is transcriptionally repressed by thyroid hormone. Cuadrado A, etal., J Neurochem. 2003 Aug;86(3):763-73.
8. Expression of HuD protein is essential for initial phase of neuronal differentiation in rat pheochromocytoma PC12 cells. Dobashi Y, etal., Biochem Biophys Res Commun. 1998 Mar 6;244(1):226-9.
9. The survival of motor neuron (SMN) protein interacts with the mRNA-binding protein HuD and regulates localization of poly(A) mRNA in primary motor neuron axons. Fallini C, etal., J Neurosci. 2011 Mar 9;31(10):3914-25. doi: 10.1523/JNEUROSCI.3631-10.2011.
10. PKC activation during training restores mushroom spine synapses and memory in the aged rat. Hongpaisan J, etal., Neurobiol Dis. 2013 Jul;55:44-62. doi: 10.1016/j.nbd.2013.03.012. Epub 2013 Mar 29.
11. Protein kinase C stimulates HuD-mediated mRNA stability and protein expression of neurotrophic factors and enhances dendritic maturation of hippocampal neurons in culture. Lim CS and Alkon DL, Hippocampus. 2012 Dec;22(12):2303-19. doi: 10.1002/hipo.22048. Epub 2012 Jun 27.
12. Increase of the RNA-binding protein HuD and posttranscriptional up-regulation of the GAP-43 gene during spatial memory. Pascale A, etal., Proc Natl Acad Sci U S A. 2004 Feb 3;101(5):1217-22. Epub 2004 Jan 26.
13. GOA pipeline RGD automated data pipeline
14. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
15. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
16. GAP-43 mRNA in growth cones is associated with HuD and ribosomes. Smith CL, etal., J Neurobiol. 2004 Nov;61(2):222-35.
17. Activity-dependent expression of ELAV/Hu RBPs and neuronal mRNAs in seizure and cocaine brain. Tiruchinapalli DM, etal., J Neurochem. 2008 Dec;107(6):1529-43. doi: 10.1111/j.1471-4159.2008.05718.x. Epub 2008 Nov 6.
18. HuD interacts with Bdnf mRNA and is essential for activity-induced BDNF synthesis in dendrites. Vanevski F and Xu B, PLoS One. 2015 Feb 18;10(2):e0117264. doi: 10.1371/journal.pone.0117264. eCollection 2015.
19. A HuD-ZBP1 ribonucleoprotein complex localizes GAP-43 mRNA into axons through its 3' untranslated region AU-rich regulatory element. Yoo S, etal., J Neurochem. 2013 Sep;126(6):792-804. doi: 10.1111/jnc.12266. Epub 2013 Apr 30.
20. Melatonin-mediated insulin synthesis during endoplasmic reticulum stress involves HuD expression in rat insulinoma INS-1E cells. Yoo YM J Pineal Res. 2013 Sep;55(2):207-20. doi: 10.1111/jpi.12064. Epub 2013 May 28.
Additional References at PubMed
PMID:8717365   PMID:10710437   PMID:12034726   PMID:12477932   PMID:16508003   PMID:17534028   PMID:18769135   PMID:19115409   PMID:21139978   PMID:22871113   PMID:23836929   PMID:24599466  
PMID:25944900   PMID:26152301   PMID:28849006   PMID:28871047   PMID:31173231  


Genomics

Comparative Map Data
Elavl4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85130,285,418 - 130,429,106 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl5130,285,418 - 130,429,096 (-)EnsemblGRCr8
mRatBN7.25125,056,848 - 125,200,543 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5125,056,848 - 125,200,446 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx5127,668,033 - 127,750,245 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05129,391,090 - 129,473,304 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05129,442,384 - 129,524,600 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.05130,001,387 - 130,144,557 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5130,001,372 - 130,085,838 (-)Ensemblrn6Rnor6.0
Rnor_5.05133,837,537 - 133,979,844 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.45131,672,012 - 131,767,950 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera5123,783,448 - 123,864,325 (-)NCBICelera
Cytogenetic Map5q35NCBI
ELAVL4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38150,048,055 - 50,203,772 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl150,024,029 - 50,203,772 (+)Ensemblhg38GRCh38
GRCh37150,513,727 - 50,669,444 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36150,347,225 - 50,439,648 (+)NCBIBuild 36Build 36hg18NCBI36
Build 34150,286,657 - 50,379,074NCBI
Celera148,799,541 - 48,953,474 (+)NCBICelera
Cytogenetic Map1p33-p32.3NCBI
HuRef148,632,219 - 48,786,277 (+)NCBIHuRef
CHM1_1150,630,724 - 50,784,575 (+)NCBICHM1_1
T2T-CHM13v2.0149,927,008 - 50,082,746 (+)NCBIT2T-CHM13v2.0
Elavl4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394110,060,934 - 110,209,127 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4110,060,919 - 110,209,106 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm384110,203,737 - 110,351,939 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4110,203,722 - 110,351,909 (-)Ensemblmm10GRCm38
MGSCv374109,876,342 - 110,024,516 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv364109,701,669 - 109,785,443 (-)NCBIMGSCv36mm8
Celera4108,542,389 - 108,690,370 (-)NCBICelera
Cytogenetic Map4C7NCBI
cM Map451.42NCBI
Elavl4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554648,699,088 - 8,788,878 (-)Ensembl
ChiLan1.0NW_0049554648,699,142 - 8,847,289 (-)NCBIChiLan1.0ChiLan1.0
ELAVL4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21176,667,027 - 176,823,109 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11175,807,675 - 175,963,772 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0149,288,364 - 49,444,457 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1150,795,037 - 50,951,058 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl150,853,276 - 50,951,058 (+)EnsemblpanPan2panpan1.1
ELAVL4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11510,885,161 - 10,977,383 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1510,887,347 - 11,027,621 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1511,035,584 - 11,127,727 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01511,021,674 - 11,113,864 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1511,023,885 - 11,165,914 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11510,821,693 - 10,912,118 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01510,910,280 - 11,000,453 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01510,927,186 - 11,017,414 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Elavl4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505864,929,747 - 65,066,032 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493652210,349,571 - 10,486,427 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493652210,349,684 - 10,435,963 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ELAVL4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl6161,785,770 - 161,928,910 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.16161,784,146 - 161,928,953 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
ELAVL4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12082,712,987 - 82,869,013 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2082,712,944 - 82,806,387 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366603334,379,488 - 34,475,682 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Elavl4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248592,874,945 - 3,023,001 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248592,875,652 - 3,023,142 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Elavl4
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1142,902,191 - 42,989,048 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Elavl4
803 total Variants
miRNA Target Status (No longer updated)

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
Mir141rno-miR-141-3pMirtarbaseexternal_infoqRT-PCRFunctional MTI (Weak)20584986
Mir21rno-miR-21-5pMirtarbaseexternal_infoqRT-PCRFunctional MTI (Weak)20584986

Predicted Target Of
Summary Value
Count of predictions:27
Count of miRNA genes:24
Interacting mature miRNAs:27
Transcripts:ENSRNOT00000035252
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1331796Thshl2Thyroid stimulating hormone level QTL 22.3blood thyroid-stimulating hormone amount (VT:0005119)serum thyroid stimulating hormone level (CMO:0001248)5102105698152749382Rat
2303586Gluco52Glucose level QTL 522blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)5100826632145826632Rat
10053720Scort26Serum corticosterone level QTL 262.060.0147blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)5130249266172190305Rat
1549845Scl44Serum cholesterol level QTL 446blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)544924861153890773Rat
8552960Pigfal15Plasma insulin-like growth factor 1 level QTL 15blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)5116702075161702075Rat
70212Niddm25Non-insulin dependent diabetes mellitus QTL 253.54blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)538207390136631402Rat
61452Ciaa5CIA Autoantibody QTL 53.5blood autoantibody amount (VT:0003725)calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)599905133172190305Rat
1331801Rf33Renal function QTL 334.149kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)548523123134369373Rat
1582230Bw78Body weight QTL 783.20.0016epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)5124314582133270832Rat
7411582Foco3Food consumption QTL 37.50.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)592583776137583776Rat
61393Bp7Blood pressure QTL 74.50.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)565089051166764498Rat
7207486Bss109Bone structure and strength QTL 109femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)5112142946157142946Rat
7207481Bss106Bone structure and strength QTL 1067.9femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)5112142946157142946Rat
1302790Scl20Serum cholesterol level QTL 206.40.0001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)5110770739155770739Rat
1578766Tcas11Tongue tumor susceptibility QTL 114.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)551657967166600247Rat
1549838Bss4Bone structure and strength QTL 49.2femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)5112142946157142946Rat
7411564Bw135Body weight QTL 1350.001body mass (VT:0001259)body weight gain (CMO:0000420)592583776137583776Rat
8657050Bw146Body weight QTL 14619.840.001body mass (VT:0001259)body weight gain (CMO:0000420)598972960143972960Rat
1581510Cm54Cardiac mass QTL 543.40.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)5125969677172190305Rat
11528624Bss114Bone structure and strength QTL 1146.543e-07femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)5129627938131996704Rat
1576312Emca8Estrogen-induced mammary cancer QTL 84.1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)555124766172190305Rat
7411601Foco12Food consumption QTL 1219.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)592583776137583776Rat
2303618Vencon1Ventilatory control QTL 13.8respiration trait (VT:0001943)oxygen consumption (CMO:0002169)5100826632145826632Rat
2317056Wbc3White blood cell count QTL 32.510.01leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)5111236572156236572Rat
7394710Emca12Estrogen-induced mammary cancer QTL 12mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)594034903139034903Rat
1598847Cm62Cardiac mass QTL 623.4heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)5114131300159131300Rat
2293642Bss37Bone structure and strength QTL 374.640.0001femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)5125969677156302135Rat
1358909Kidm25Kidney mass QTL 251.87kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)595062526133270832Rat
70189Mcs5Mammary carcinoma susceptibility QTL 510.51mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)560601597137492949Rat
7207488Bss110Bone structure and strength QTL 18.4femur strength trait (VT:0010010)femur stiffness (CMO:0001674)5112142946157142946Rat
8694441Bw169Body weight QTL 16917.610.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)5116702075161702075Rat
7207491Bss112Bone structure and strength QTL 1127femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)5112142946157142946Rat
8694389Bw160Body weight QTL 1606.170.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)5116702075161702075Rat
2290448Scl54Serum cholesterol level QTL 542.93blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)536460764136631402Rat
1354598Srn6Serum renin concentration QTL 63.8blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)574335621156302135Rat
8694198Abfw3Abdominal fat weight QTL 316.130.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)5116702075161702075Rat
1298086Bp156Blood pressure QTL 156arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)589369373134369373Rat
2306971Anxrr21Anxiety related response QTL 219.47fear/anxiety-related behavior trait (VT:1000241)number of entries into a discrete space in an experimental apparatus (CMO:0000960)570969494136328156Rat
1298089Scl14Serum cholesterol level QTL 145.80.0004blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)5114131300159131300Rat
1358895Bp254Blood pressure QTL 2543.60.0003arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)597492524133270832Rat
6903316Bw113Body weight QTL 11320.0103body mass (VT:0001259)body weight (CMO:0000012)592881678137881678Rat
1358889Bp261Blood pressure QTL 2612.86arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)595062526133270832Rat
1358187Emca1Estrogen-induced mammary cancer QTL 14.4mammary gland integrity trait (VT:0010552)post-insult time to mammary tumor formation (CMO:0000345)5104262817153890625Rat

Markers in Region
BB464020  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25125,057,610 - 125,057,695 (+)MAPPERmRatBN7.2
Rnor_6.05130,002,150 - 130,002,234NCBIRnor6.0
Rnor_5.05133,838,300 - 133,838,384UniSTSRnor5.0
RGSC_v3.45131,670,388 - 131,670,472UniSTSRGSC3.4
Celera5123,784,211 - 123,784,295UniSTS
Cytogenetic Map5q35UniSTS
RH131794  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25125,067,409 - 125,067,603 (+)MAPPERmRatBN7.2
Rnor_6.05130,011,948 - 130,012,141NCBIRnor6.0
Rnor_5.05133,848,098 - 133,848,291UniSTSRnor5.0
RGSC_v3.45131,680,186 - 131,680,379UniSTSRGSC3.4
Celera5123,794,010 - 123,794,203UniSTS
RH 3.4 Map5820.9UniSTS
Cytogenetic Map5q35UniSTS
PMC337033P2  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25125,059,245 - 125,059,374 (+)MAPPERmRatBN7.2
Rnor_6.05130,003,785 - 130,003,913NCBIRnor6.0
Rnor_5.05133,839,935 - 133,840,063UniSTSRnor5.0
RGSC_v3.45131,672,023 - 131,672,151UniSTSRGSC3.4
Celera5123,785,846 - 123,785,974UniSTS
Cytogenetic Map5q35UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 8 58 146 68 67 37 32 37 6 214 113 1 129 42 85 30 17 17

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001077651 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006238591 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006238593 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006238594 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008763893 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017593551 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039110515 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039110516 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063288153 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063288154 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063288155 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063288156 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063288157 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide BC158558 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000005 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  S83320 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000035252   ⟹   ENSRNOP00000037614
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl5130,285,418 - 130,367,663 (-)Ensembl
mRatBN7.2 Ensembl5125,056,848 - 125,139,100 (-)Ensembl
Rnor_6.0 Ensembl5130,001,372 - 130,085,838 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000098972   ⟹   ENSRNOP00000096475
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl5130,287,489 - 130,419,989 (-)Ensembl
mRatBN7.2 Ensembl5125,058,877 - 125,145,091 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000101036   ⟹   ENSRNOP00000076930
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl5130,287,000 - 130,368,536 (-)Ensembl
mRatBN7.2 Ensembl5125,059,431 - 125,200,446 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000101531   ⟹   ENSRNOP00000095267
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl5130,285,418 - 130,368,466 (-)Ensembl
mRatBN7.2 Ensembl5125,056,848 - 125,140,002 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000104896   ⟹   ENSRNOP00000079852
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl5130,285,418 - 130,333,085 (-)Ensembl
mRatBN7.2 Ensembl5125,056,848 - 125,104,518 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000108484   ⟹   ENSRNOP00000090516
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl5130,287,000 - 130,371,269 (-)Ensembl
mRatBN7.2 Ensembl5125,058,877 - 125,142,708 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000109917   ⟹   ENSRNOP00000086190
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl5130,285,418 - 130,429,096 (-)Ensembl
mRatBN7.2 Ensembl5125,059,431 - 125,139,100 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000110462   ⟹   ENSRNOP00000093173
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl5130,287,000 - 130,373,650 (-)Ensembl
mRatBN7.2 Ensembl5125,058,877 - 125,104,799 (-)Ensembl
RefSeq Acc Id: NM_001077651   ⟹   NP_001071119
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85130,285,418 - 130,367,663 (-)NCBI
mRatBN7.25125,056,848 - 125,139,100 (-)NCBI
Rnor_6.05130,001,387 - 130,085,772 (-)NCBI
Rnor_5.05133,837,537 - 133,979,844 (-)NCBI
RGSC_v3.45131,672,012 - 131,767,950 (-)RGD
Celera5123,783,448 - 123,864,325 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006238591   ⟹   XP_006238653
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85130,285,418 - 130,371,990 (-)NCBI
mRatBN7.25125,056,848 - 125,143,349 (-)NCBI
Rnor_6.05130,001,387 - 130,090,240 (-)NCBI
Rnor_5.05133,837,537 - 133,979,844 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006238593   ⟹   XP_006238655
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85130,285,418 - 130,429,106 (-)NCBI
mRatBN7.25125,056,848 - 125,200,543 (-)NCBI
Rnor_6.05130,001,387 - 130,144,557 (-)NCBI
Rnor_5.05133,837,537 - 133,979,844 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006238594   ⟹   XP_006238656
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85130,285,418 - 130,368,595 (-)NCBI
mRatBN7.25125,056,848 - 125,139,977 (-)NCBI
Rnor_6.05130,001,387 - 130,086,674 (-)NCBI
Rnor_5.05133,837,537 - 133,979,844 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039110515   ⟹   XP_038966443
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85130,285,418 - 130,371,970 (-)NCBI
mRatBN7.25125,056,848 - 125,143,348 (-)NCBI
RefSeq Acc Id: XM_039110516   ⟹   XP_038966444
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85130,285,418 - 130,371,899 (-)NCBI
mRatBN7.25125,056,848 - 125,143,350 (-)NCBI
RefSeq Acc Id: XM_063288153   ⟹   XP_063144223
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85130,285,418 - 130,367,910 (-)NCBI
RefSeq Acc Id: XM_063288154   ⟹   XP_063144224
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85130,285,418 - 130,429,106 (-)NCBI
RefSeq Acc Id: XM_063288155   ⟹   XP_063144225
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85130,285,418 - 130,368,556 (-)NCBI
RefSeq Acc Id: XM_063288156   ⟹   XP_063144226
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85130,285,418 - 130,367,911 (-)NCBI
RefSeq Acc Id: XM_063288157   ⟹   XP_063144227
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85130,285,418 - 130,368,545 (-)NCBI
RefSeq Acc Id: NP_001071119   ⟸   NM_001077651
- UniProtKB: O09032 (UniProtKB/Swiss-Prot),   A0A140TAF2 (UniProtKB/TrEMBL),   A0A8I5ZNE4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006238655   ⟸   XM_006238593
- Peptide Label: isoform X2
- UniProtKB: A0A8I5ZNE4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006238653   ⟸   XM_006238591
- Peptide Label: isoform X1
- UniProtKB: A0A8I5ZNE4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006238656   ⟸   XM_006238594
- Peptide Label: isoform X3
- UniProtKB: A0A8I6APY9 (UniProtKB/TrEMBL),   A0A8I5ZNE4 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000037614   ⟸   ENSRNOT00000035252
RefSeq Acc Id: XP_038966444   ⟸   XM_039110516
- Peptide Label: isoform X8
- UniProtKB: A0A8I6AV49 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038966443   ⟸   XM_039110515
- Peptide Label: isoform X4
- UniProtKB: A0A8I6AV49 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000076930   ⟸   ENSRNOT00000101036
Ensembl Acc Id: ENSRNOP00000096475   ⟸   ENSRNOT00000098972
Ensembl Acc Id: ENSRNOP00000090516   ⟸   ENSRNOT00000108484
Ensembl Acc Id: ENSRNOP00000093173   ⟸   ENSRNOT00000110462
Ensembl Acc Id: ENSRNOP00000086190   ⟸   ENSRNOT00000109917
Ensembl Acc Id: ENSRNOP00000095267   ⟸   ENSRNOT00000101531
Ensembl Acc Id: ENSRNOP00000079852   ⟸   ENSRNOT00000104896
RefSeq Acc Id: XP_063144224   ⟸   XM_063288154
- Peptide Label: isoform X6
- UniProtKB: A0A8I6AV49 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063144225   ⟸   XM_063288155
- Peptide Label: isoform X7
- UniProtKB: A0A8I6AV49 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063144227   ⟸   XM_063288157
- Peptide Label: isoform X10
- UniProtKB: A0A8I6AV49 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063144226   ⟸   XM_063288156
- Peptide Label: isoform X9
- UniProtKB: A0A8I6AV49 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063144223   ⟸   XM_063288153
- Peptide Label: isoform X5
- UniProtKB: A0A8I6AV49 (UniProtKB/TrEMBL)
Protein Domains
RRM

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O09032-F1-model_v2 AlphaFold O09032 1-385 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1560027 AgrOrtholog
BioCyc Gene G2FUF-40341 BioCyc
Ensembl Genes ENSRNOG00000023601 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000035252 ENTREZGENE
  ENSRNOT00000035252.4 UniProtKB/Swiss-Prot
  ENSRNOT00000101036 ENTREZGENE
  ENSRNOT00000101531 ENTREZGENE
  ENSRNOT00000109917 ENTREZGENE
  ENSRNOT00000110462 ENTREZGENE
Gene3D-CATH 3.30.70.330 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:8371379 IMAGE-MGC_LOAD
InterPro ELAD_HU_SF UniProtKB/Swiss-Prot
  HuD_RRM3 UniProtKB/Swiss-Prot
  Hud_Sxl_RNA UniProtKB/Swiss-Prot
  Nucleotide-bd_a/b_plait_sf UniProtKB/Swiss-Prot
  RBD_domain_sf UniProtKB/Swiss-Prot
  RRM_dom UniProtKB/Swiss-Prot
KEGG Report rno:432358 UniProtKB/Swiss-Prot
MGC_CLONE MGC:187234 IMAGE-MGC_LOAD
NCBI Gene 432358 ENTREZGENE
PANTHER EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT G UniProtKB/Swiss-Prot
Pfam RRM_1 UniProtKB/Swiss-Prot
PhenoGen Elavl4 PhenoGen
PRINTS HUDSXLRNA UniProtKB/Swiss-Prot
PROSITE RRM UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000023601 RatGTEx
SMART RRM UniProtKB/Swiss-Prot
Superfamily-SCOP SSF54928 UniProtKB/Swiss-Prot
UniProt A0A140TAF2 ENTREZGENE
  A0A8I5Y0H9_RAT UniProtKB/TrEMBL
  A0A8I5ZNE4 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6A344_RAT UniProtKB/TrEMBL
  A0A8I6ADY8_RAT UniProtKB/TrEMBL
  A0A8I6AI53_RAT UniProtKB/TrEMBL
  A0A8I6APY9 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AV49 ENTREZGENE, UniProtKB/TrEMBL
  B0BMT8_RAT UniProtKB/TrEMBL
  ELAV4_RAT UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary A0A140TAF2 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-09-09 Elavl4  ELAV like RNA binding protein 4  Elavl4  ELAV like neuron-specific RNA binding protein 4  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2013-11-11 Elavl4  ELAV like neuron-specific RNA binding protein 4  Elavl4  ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2012-07-16 Elavl4  ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4  Elavl4  ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-01-09 Elavl4  ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)  RGD1561943_predicted  similar to ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D) (predicted)  Data merged from RGD:1561943 1643240 APPROVED
2006-03-10 RGD1561943_predicted  similar to ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D) (predicted)      Name updated 1299863 APPROVED
2006-03-07 RGD1561943_predicted  similar to ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D) (predicted)  LOC298359  similar to ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 Elavl4  ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)      Symbol and Name status set to provisional 70820 PROVISIONAL
2006-02-09 LOC298359  similar to ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)      Symbol and Name status set to provisional 70820 PROVISIONAL