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Gene: Arpc3 (actin related protein 2/3 complex, subunit 3) Rattus norvegicus

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Symbol:

Arpc3

Name:

actin related protein 2/3 complex, subunit 3

RGD ID:

1311985

Description:

Predicted to be a structural constituent of cytoskeleton. Predicted to contribute to actin filament binding activity. Involved in cellular response to nerve growth factor stimulus. Located in growth cone leading edge. Part of filamentous actin. Used to study Parkinson's disease. Orthologous to human ARPC3 (actin related protein 2/3 complex subunit 3); PARTICIPATES IN insulin responsive facilitative sugar transporter mediated glucose transport pathway; platelet-derived growth factor signaling pathway; Rab family mediated signaling pathway; INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,6-dinitrotoluene.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

actin-related protein 2/3 complex subunit 3; LOC288669

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	ARPC3 (actin related protein 2/3 complex subunit 3)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):	Arpc3 (actin related protein 2/3 complex, subunit 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Arpc3 (actin related protein 2/3 complex subunit 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	ARPC3 (actin related protein 2/3 complex subunit 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	ARPC3 (actin related protein 2/3 complex subunit 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	LOC101978301 (uncharacterized LOC101978301)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	ARPC3 (actin related protein 2/3 complex subunit 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	ARPC3 (actin related protein 2/3 complex subunit 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Arpc3 (actin related protein 2/3 complex subunit 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus rattus (black rat):	Arpc3 (actin related protein 2/3 complex subunit 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	ARPC3 (actin related protein 2/3 complex subunit 3)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Homo sapiens (human):	ARPC3 (actin related protein 2/3 complex subunit 3)	Alliance	DIOPT (HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Arpc3 (actin related protein 2/3 complex, subunit 3)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	arpc3 (actin related protein 2/3 complex, subunit 3)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	ARC18	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	Arpc3A	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	Arpc3B	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	arx-5	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	arpc3	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	12	39,833,569 - 39,847,436 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	12	39,833,569 - 39,847,436 (-)	Ensembl				GRCr8
mRatBN7.2	12	34,172,780 - 34,186,651 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	12	34,172,780 - 34,186,651 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	12	35,345,197 - 35,359,072 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	12	35,956,610 - 35,970,481 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	12	35,008,933 - 35,022,805 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	12	39,653,951 - 39,667,817 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	12	39,653,953 - 39,667,849 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	12	41,533,346 - 41,548,335 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	12	35,366,969 - 35,377,111 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	12	35,843,695 - 35,857,566 (-)	NCBI		Celera
RGSC_v3.1	12	35,230,356 - 35,240,663 (-)	NCBI
Cytogenetic Map	12	q16	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

diabetes mellitus (ISO)

Parkinson's disease (IDA)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2-dimethylhydrazine (ISO)

1-chloro-2,4-dinitrobenzene (ISO)

17alpha-ethynylestradiol (EXP,ISO)

2,3',4,4',5-Pentachlorobiphenyl (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,6-dimethoxyphenol (ISO)

2,6-dinitrotoluene (EXP)

3,4-methylenedioxymethamphetamine (EXP)

3-isobutyl-1-methyl-7H-xanthine (ISO)

4,4'-sulfonyldiphenol (EXP,ISO)

5-fluorouracil (ISO)

6-propyl-2-thiouracil (EXP)

all-trans-retinoic acid (ISO)

amitrole (EXP)

amphetamine (EXP)

ampicillin (EXP)

antirheumatic drug (ISO)

arsenite(3-) (ISO)

arsenous acid (ISO)

benzo[a]pyrene (ISO)

bisphenol A (EXP,ISO)

bisphenol AF (ISO)

Bisphenol B (ISO)

bisphenol F (EXP,ISO)

caffeine (ISO)

captan (ISO)

carbon nanotube (ISO)

dexamethasone (ISO)

dextran sulfate (ISO)

diarsenic trioxide (ISO)

dicrotophos (ISO)

diuron (ISO)

doxorubicin (ISO)

epoxiconazole (ISO)

ethanol (ISO)

folic acid (ISO)

furfural (ISO)

genistein (ISO)

gentamycin (EXP)

hydrogen peroxide (ISO)

indometacin (ISO)

ivermectin (ISO)

manganese atom (ISO)

manganese(0) (ISO)

manganese(II) chloride (ISO)

methidathion (ISO)

methimazole (EXP)

metronidazole (EXP)

neomycin (EXP)

nitrates (ISO)

propiconazole (EXP)

rotenone (ISO)

sodium arsenite (ISO)

sodium chloride (ISO)

sulfadimethoxine (EXP)

sunitinib (ISO)

tamoxifen (ISO)

tetrahydropalmatine (ISO)

thapsigargin (ISO)

thioacetamide (EXP)

titanium dioxide (ISO)

triphenyl phosphate (ISO)

triptonide (ISO)

vancomycin (EXP)

vinclozolin (EXP)

vorinostat (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

Arp2/3 complex-mediated actin nucleation (IBA,IEA,ISO)

cellular response to nerve growth factor stimulus (IEP)

regulation of actin filament polymerization (IEA)

regulation of synaptic vesicle endocytosis (ISO)

Cellular Component

Arp2/3 protein complex (IBA,IEA,ISO)

cell leading edge (IDA)

cell projection (IEA)

cytoskeleton (IEA)

filamentous actin (IDA)

growth cone leading edge (IDA)

lamellipodium (IEA,ISO)

nucleus (IEA)

Molecular Function

actin binding (IEA)

actin filament binding (IBA,IEA,ISO)

protein binding (ISO)

structural constituent of cytoskeleton (IEA,ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

Fc gamma receptor mediated signaling pathway (IEA)

insulin responsive facilitative sugar transporter mediated glucose transport pathway (ISO)

platelet-derived growth factor signaling pathway (ISO)

Rab family mediated signaling pathway (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Relationship between Arp2/3 complex and the barbed ends of actin filaments at the leading edge of carcinoma cells after epidermal growth factor stimulation.	Bailly M, etal., J Cell Biol. 1999 Apr 19;145(2):331-45.
2.	Arp2/3- and cofilin-coordinated actin dynamics is required for insulin-mediated GLUT4 translocation to the surface of muscle cells.	Chiu TT, etal., Mol Biol Cell. 2010 Oct 15;21(20):3529-39. doi: 10.1091/mbc.E10-04-0316. Epub 2010 Aug 25.
3.	Global Gene Expression Profiling in Omental Adipose Tissue of Morbidly Obese Diabetic African Americans.	Doumatey AP, etal., J Endocrinol Metab. 2015 Jun;5(3):199-210.
4.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
6.	Recruitment of the Arp2/3 complex and mena for the stimulation of actin polymerization in growth cones by nerve growth factor.	Goldberg DJ, etal., J Neurosci Res. 2000 May 15;60(4):458-67.
7.	Antiparkinsonian trophic action of glial cell line-derived neurotrophic factor and transforming growth factor beta1 is enhanced after co-infusion in rats.	Gonzalez-Aparicio R, etal., Exp Neurol. 2010 Nov;226(1):136-47. doi: 10.1016/j.expneurol.2010.08.016. Epub 2010 Aug 14.
8.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
9.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
10.	PID Annotation Import Pipeline	Pipeline to import Pathway Interaction Database annotations from NCI into RGD
11.	GOA pipeline	RGD automated data pipeline
12.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
13.	Comprehensive gene review and curation	RGD comprehensive gene curation

Additional References at PubMed

PMID:9230079	PMID:11741539	PMID:12477932	PMID:15252126	PMID:15294161	PMID:18509026	PMID:19056867	PMID:19946888	PMID:20458337	PMID:21423176	PMID:23376485	PMID:23533145

Genomics

Comparative Map Data

Arpc3
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	12	39,833,569 - 39,847,436 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	12	39,833,569 - 39,847,436 (-)	Ensembl				GRCr8
mRatBN7.2	12	34,172,780 - 34,186,651 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	12	34,172,780 - 34,186,651 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	12	35,345,197 - 35,359,072 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	12	35,956,610 - 35,970,481 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	12	35,008,933 - 35,022,805 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	12	39,653,951 - 39,667,817 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	12	39,653,953 - 39,667,849 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	12	41,533,346 - 41,548,335 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	12	35,366,969 - 35,377,111 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	12	35,843,695 - 35,857,566 (-)	NCBI		Celera
RGSC_v3.1	12	35,230,356 - 35,240,663 (-)	NCBI
Cytogenetic Map	12	q16	NCBI

ARPC3
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	12	110,434,823 - 110,450,337 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	12	110,434,582 - 110,450,422 (-)	Ensembl			hg38	GRCh38
GRCh37	12	110,872,628 - 110,888,142 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	12	109,357,089 - 109,372,541 (-)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	12	109,335,426 - 109,350,878	NCBI
Celera	12	110,499,460 - 110,514,921 (-)	NCBI		Celera
Cytogenetic Map	12	q24.11	NCBI
HuRef	12	107,890,831 - 107,906,550 (-)	NCBI		HuRef
CHM1_1	12	110,840,525 - 110,856,046 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	12	110,412,518 - 110,428,033 (-)	NCBI		T2T-CHM13v2.0

Arpc3
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	5	122,529,941 - 122,544,244 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	5	122,529,941 - 122,552,247 (+)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	5	122,391,878 - 122,406,181 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	5	122,391,878 - 122,414,184 (+)	Ensembl			mm10	GRCm38
MGSCv37	5	122,841,937 - 122,856,187 (+)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	5	122,652,545 - 122,666,795 (+)	NCBI		MGSCv36	mm8
Celera	5	119,470,471 - 119,484,714 (+)	NCBI		Celera
Cytogenetic Map	5	F	NCBI
cM Map	5	62.34	NCBI

Arpc3
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955482	7,350,456 - 7,364,266 (-)	Ensembl
ChiLan1.0	NW_004955482	7,350,456 - 7,364,266 (-)	NCBI	ChiLan1.0	ChiLan1.0

ARPC3
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	10	118,498,814 - 118,514,420 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	12	118,495,217 - 118,510,697 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	12	108,007,884 - 108,023,386 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	12	111,395,800 - 111,415,170 (-)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	12	111,399,433 - 111,415,156 (-)	Ensembl			panPan2	panpan1.1

ARPC3
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	26	8,267,123 - 8,277,779 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	26	8,267,196 - 8,277,688 (-)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	26	8,430,745 - 8,441,421 (-)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	26	8,524,788 - 8,535,469 (-)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	26	8,524,794 - 8,535,367 (-)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	26	8,484,142 - 8,494,810 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	26	8,542,697 - 8,553,529 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	26	8,497,864 - 8,508,751 (-)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

LOC101978301
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405118	156,057,681 - 156,061,635 (+)	NCBI		HiC_Itri_2
SpeTri2.0	NW_004936558	3,418,664 - 3,421,693 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

ARPC3
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	14	31,814,151 - 31,826,855 (-)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	14	31,814,382 - 31,823,452 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	14	33,736,371 - 33,745,205 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

ARPC3
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	11	105,670,798 - 105,685,911 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
Vero_WHO_p1.0	NW_023666037	139,433,833 - 139,450,140 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Arpc3
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624747	21,438,612 - 21,454,753 (+)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624747	21,438,602 - 21,451,154 (+)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Arpc3
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	16	31,448,934 - 31,463,617 (-)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Arpc3
167 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	25
Count of miRNA genes:	25
Interacting mature miRNAs:	25
Transcripts:	ENSRNOT00000011499
Prediction methods:	Miranda, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
631560	Apr1	Acute phase response QTL 1	6.1		orosomucoid 1 amount (VT:0010541)	plasma orosomucoid 1 level (CMO:0001467)	12	24805022	52308831	Rat
70213	Niddm27	Non-insulin dependent diabetes mellitus QTL 27	3.72		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	12	11200494	52308831	Rat
8552964	Pigfal17	Plasma insulin-like growth factor 1 level QTL 17	3.5		blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	12	11200494	52308831	Rat
8693635	Alc28	Alcohol consumption QTL 28	2.7	0.439	drinking behavior trait (VT:0001422)	calculated ethanol drink intake rate (CMO:0001615)	12	28717718	50386405	Rat
7411641	Foco19	Food consumption QTL 19	27.7	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	12	11200494	52308831	Rat
7411643	Foco20	Food consumption QTL 20		0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	12	25989355	52308831	Rat
5684888	Pia42	Pristane induced arthritis QTL 42			joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	12	3489416	48489416	Rat
1641928	Alcrsp5	Alcohol response QTL 5			response to alcohol trait (VT:0010489)	duration of loss of righting reflex (CMO:0002289)	12	18473041	52308831	Rat
1300162	Bp188	Blood pressure QTL 188	3.19		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	12	37764145	51558799	Rat
8552912	Pigfal6	Plasma insulin-like growth factor 1 level QTL 6	5		blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	12	11200497	52308831	Rat
1549829	Scl48	Serum cholesterol level QTL 48	5		blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	12	15264248	52308831	Rat
10059594	Kidm46	Kidney mass QTL 46	3.79	0.025	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	12	11743528	52308831	Rat
8552918	Pigfal7	Plasma insulin-like growth factor 1 level QTL 7			blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	12	11200494	52308831	Rat
70169	Eae13	Experimental allergic encephalomyelitis QTL 13		0.032	nervous system integrity trait (VT:0010566)	experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)	12	29775522	42298555	Rat
1600386	Calcic2	Intracellular calcium level QTL 2		0.001	platelet physiology trait (VT:0005464)	platelet intracellular calcium level (CMO:0000922)	12	33700432	46784661	Rat
61404	Bw120	Body weight QTL 120	5.1		body mass (VT:0001259)	body mass index (BMI) (CMO:0000105)	12	17464979	46784661	Rat
1556747	Calcic1	Intracellular calcium level QTL 1		3.6	platelet calcium amount (VT:0010500)	platelet intracellular calcium level (CMO:0000922)	12	33700432	46784661	Rat
1300175	Cm5	Cardiac mass QTL 5	3.78		heart mass (VT:0007028)	heart left ventricle weight to body weight ratio (CMO:0000530)	12	33700432	51558799	Rat
631829	Alc6	Alcohol consumption QTL 6	4.7		consumption behavior trait (VT:0002069)	ethanol drink intake rate (CMO:0001407)	12	34243475	43352593	Rat
1331786	Kidm11	Kidney mass QTL 11	3.571		kidney mass (VT:0002707)	right kidney wet weight (CMO:0000082)	12	16187438	52308831	Rat
8693658	Alc33	Alcohol consumption QTL 33	2.1	0.68	drinking behavior trait (VT:0001422)	calculated ethanol drink intake rate (CMO:0001615)	12	28717718	49212240	Rat
2293699	Bss49	Bone structure and strength QTL 49	5.61	0.0001	lumbar vertebra size trait (VT:0010518)	lumbar vertebra trabecular cross-sectional area (CMO:0001692)	12	16135029	52308831	Rat
1331761	Bp218	Blood pressure QTL 218	2.973		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	12	16187438	51213550	Rat
1331763	Wbc2	White blood cell count QTL 2	3.162		leukocyte quantity (VT:0000217)	total white blood cell count (CMO:0000365)	12	11200494	52308831	Rat
7411547	Bw129	Body weight QTL 129		0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	6	11200494	52308831	Rat
7387292	Kidm42	Kidney mass QTL 42	3.03	0.0004	kidney mass (VT:0002707)	left kidney wet weight (CMO:0000083)	12	1	41361854	Rat
1298081	Cia25	Collagen induced arthritis QTL 25	4.7		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	12	2747694	47747694	Rat
2303569	Gluco44	Glucose level QTL 44	2		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	12	18473041	52308831	Rat
2303575	Insul14	Insulin level QTL 14	4		blood insulin amount (VT:0001560)	blood insulin level (CMO:0000349)	12	3087180	48087180	Rat
7411588	Foco6	Food consumption QTL 6		0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	12	11200494	52308831	Rat
7243862	Mcs30	Mammary carcinoma susceptibility QTL 30	8.62		mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	12	5633306	50633306	Rat
2300186	Bmd59	Bone mineral density QTL 59	7.1	0.0001	lumbar vertebra mineral mass (VT:0010511)	volumetric bone mineral density (CMO:0001553)	12	16135029	52308831	Rat
7411597	Foco10	Food consumption QTL 10		0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	12	11200494	52308831	Rat

Markers in Region

RH133976

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	12	34,182,468 - 34,182,663 (+)	MAPPER	mRatBN7.2
Rnor_6.0	12	39,663,639 - 39,663,833	NCBI	Rnor6.0
Rnor_5.0	12	41,544,156 - 41,544,350	UniSTS	Rnor5.0
RGSC_v3.4	12	35,376,657 - 35,376,851	UniSTS	RGSC3.4
Celera	12	35,853,390 - 35,853,584	UniSTS
RH 3.4 Map	12	605.8	UniSTS
Cytogenetic Map	12	q16	UniSTS

BF412122

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	12	34,179,199 - 34,179,350 (+)	MAPPER	mRatBN7.2
Rnor_6.0	12	39,660,371 - 39,660,521	NCBI	Rnor6.0
Rnor_5.0	12	41,539,766 - 41,539,916	UniSTS	Rnor5.0
RGSC_v3.4	12	35,373,389 - 35,373,539	UniSTS	RGSC3.4
Celera	12	35,850,122 - 35,850,272	UniSTS
RH 3.4 Map	12	596.2	UniSTS
Cytogenetic Map	12	q16	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
21	13	73	205	91	90	59	144	59	6	443	251	13	192	104	104	31	33	33

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001105933	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC104314	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC166554	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473973	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ219862	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ221109	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ232132	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ232695	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000012	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000011499 ⟹ ENSRNOP00000011499

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	12	39,833,569 - 39,847,436 (-)	Ensembl
mRatBN7.2 Ensembl	12	34,172,780 - 34,186,651 (-)	Ensembl
Rnor_6.0 Ensembl	12	39,653,953 - 39,667,849 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000099673 ⟹ ENSRNOP00000082825

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	12	39,833,569 - 39,843,909 (-)	Ensembl
mRatBN7.2 Ensembl	12	34,172,780 - 34,183,407 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000108586 ⟹ ENSRNOP00000096174

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	12	39,834,543 - 39,843,909 (-)	Ensembl
mRatBN7.2 Ensembl	12	34,173,698 - 34,186,651 (-)	Ensembl

RefSeq Acc Id:

NM_001105933 ⟹ NP_001099403

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	12	39,833,569 - 39,847,436 (-)	NCBI
mRatBN7.2	12	34,172,780 - 34,186,651 (-)	NCBI
Rnor_6.0	12	39,653,951 - 39,667,817 (-)	NCBI
Rnor_5.0	12	41,533,346 - 41,548,335 (-)	NCBI
RGSC_v3.4	12	35,366,969 - 35,377,111 (-)	RGD
Celera	12	35,843,695 - 35,857,566 (-)	RGD

Sequence:

show sequence

CCGCCTCTTCCGGCTTATTTCCGCCCACTCCACCCAGTCTAGTTTGCCGGAAACGCTGCTCCGC
TTTACCTGGGTTCAGCATCTCTAGATCGAATCCGGACACCGACAAAATGCCGGCTTACCACTCT
TCTCTCATGGACCCTGACACCAAGCTCATTGGCAACATGGCACTGCTGCCCATCCGAAGCCAGT
TCAAAGGACCCGCCCCTCGAGAGACGAAAGACACGGATATTGTGGATGAAGCCATCTATTACTT
CAAGGCCAACGTCTTCTTCAAGAACTATGAAATTAAGAATGAAGCGGACAGGACCTTGATCTAC
ATCACACTCTACATTTCTGAGTGTCTAAAGAAGCTCCAAAAGTGCAACTCCAGAAGCCAAGGCG
AGAAAGAAATGTACACGCTAGGAATCACCAACTTTCCCATTCCTGGCGAGCCTGGCTTTCCCCT
CAACGCCATTTACGCCAAACCTGCCAGCAAACAGGAGGATGAAACGATGCGCGCGTACCTACAG
CAGCTGAGGCAAGAGACCGGACTGAGGCTTTGTGACAAAGTTTTTGACCCTCAGAATGATAAAC
CAAGCAAGTGGTGGACTTGCTTTGTGAAGAGACAGTTCATGAACAAGAGTCTTTCGGGGCCCGG
GCAGTGAGAGGAGCCATGGTCAGCATCGCATTGAGGTGTACACAGTCCTATGTGTTTGTTCTTA
ACGTGTCACGAGAGGAGAGAGCCTGTCTACCGGGAAAGCTCTCGGTCAAGAGTTTGGAGGGTGG
GTGTCGGGTTTGAATTTCAAGCTGGTACTTCATATGTAATAAATGTCGCTGCTTATGTTAGACA
GACATTGAATTAAAACATTTTTGAGAAAAAGCGTACACAA

hide sequence

Protein Sequences


Protein RefSeqs	NP_001099403	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAI66554	(Get FASTA)	NCBI Sequence Viewer
	EDM13686	(Get FASTA)	NCBI Sequence Viewer
	EDM13687	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000011499
	ENSRNOP00000011499.5
	ENSRNOP00000082825.2
	ENSRNOP00000096174.2

RefSeq Acc Id:	NP_001099403 ⟸ NM_001105933
- UniProtKB:	B2GV73 (UniProtKB/TrEMBL), F1LRL8 (UniProtKB/TrEMBL), A0A9K3Y7C4 (UniProtKB/TrEMBL), A0A8I5ZU90 (UniProtKB/TrEMBL)
- Sequence:	show sequence MPAYHSSLMDPDTKLIGNMALLPIRSQFKGPAPRETKDTDIVDEAIYYFKANVFFKNYEIKNEA DRTLIYITLYISECLKKLQKCNSRSQGEKEMYTLGITNFPIPGEPGFPLNAIYAKPASKQEDET MRAYLQQLRQETGLRLCDKVFDPQNDKPSKWWTCFVKRQFMNKSLSGPGQ hide sequence

Ensembl Acc Id:

ENSRNOP00000011499 ⟸ ENSRNOT00000011499

Ensembl Acc Id:

ENSRNOP00000082825 ⟸ ENSRNOT00000099673

Ensembl Acc Id:

ENSRNOP00000096174 ⟸ ENSRNOT00000108586

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-B2GV73-F1-model_v2	AlphaFold	B2GV73	1-178	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13698645

Promoter ID:

EPDNEW_R9169

Type:

initiation region

Name:

Arpc3_1

Description:

actin related protein 2/3 complex, subunit 3

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	12	39,667,791 - 39,667,851	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1311985	AgrOrtholog
BioCyc Gene	G2FUF-19253	BioCyc
Ensembl Genes	ENSRNOG00000008673	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000011499	ENTREZGENE
	ENSRNOT00000011499.9	UniProtKB/TrEMBL
	ENSRNOT00000099673.2	UniProtKB/TrEMBL
	ENSRNOT00000108586.2	UniProtKB/TrEMBL
Gene3D-CATH	1.10.1760.10	UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:7311069	IMAGE-MGC_LOAD
InterPro	ARP2/3_p21-Arc	UniProtKB/TrEMBL
	ARPC3_sf	UniProtKB/TrEMBL
KEGG Report	rno:288669	UniProtKB/TrEMBL
MGC_CLONE	MGC:188163	IMAGE-MGC_LOAD
NCBI Gene	288669	ENTREZGENE
PANTHER	P21-Arc	UniProtKB/TrEMBL
Pfam	P21-Arc	UniProtKB/TrEMBL
PhenoGen	Arpc3	PhenoGen
PIRSF	ARP2/3_P21-Arc	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000008673	RatGTEx
Superfamily-SCOP	ARP2/3_P21-Arc	UniProtKB/TrEMBL
UniProt	A0A8I5ZU90	ENTREZGENE, UniProtKB/TrEMBL
	A0A8I6AL89_RAT	UniProtKB/TrEMBL
	A0A9K3Y7C4	ENTREZGENE, UniProtKB/TrEMBL
	B2GV73	ENTREZGENE, UniProtKB/TrEMBL
	F1LRL8	ENTREZGENE
UniProt Secondary	F1LRL8	UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2008-04-30	Arpc3	actin related protein 2/3 complex, subunit 3	Arpc3_predicted	actin related protein 2/3 complex, subunit 3 (predicted)	'predicted' is removed	2292626	APPROVED
2005-01-12	Arpc3_predicted	actin related protein 2/3 complex, subunit 3 (predicted)			Symbol and Name status set to approved	70820	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

RGD Manual Annotations

Imported Annotations - KEGG (archival)

Imported Annotations - PID (archival)

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RGD Manual Annotations

Imported Annotations - KEGG (archival)

Imported Annotations - PID (archival)