Cpox (coproporphyrinogen oxidase) - Rat Genome Database

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Gene: Cpox (coproporphyrinogen oxidase) Rattus norvegicus
Analyze
Symbol: Cpox
Name: coproporphyrinogen oxidase
RGD ID: 1311817
Description: Enables coproporphyrinogen oxidase activity and identical protein binding activity. Involved in several processes, including protoporphyrinogen IX biosynthetic process; response to lead ion; and response to methylmercury. Located in mitochondrial inner membrane. Human ortholog(s) of this gene implicated in hereditary coproporphyria and liver disease. Orthologous to human CPOX (coproporphyrinogen oxidase); PARTICIPATES IN acute intermittent porphyria pathway; erythropoietic porphyria pathway; heme biosynthetic pathway; INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,6-dinitrotoluene.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: coprogen oxidase; coproporphyrinogen-III oxidase, mitochondrial; coproporphyrinogenase; COX; LOC304024; MGC124847; oxygen-dependent coproporphyrinogen-III oxidase, mitochondrial
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81155,405,778 - 55,415,761 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1155,405,784 - 55,415,761 (-)EnsemblGRCr8
mRatBN7.21141,936,585 - 41,946,568 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1141,936,591 - 41,946,746 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1150,684,226 - 50,694,252 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01143,345,792 - 43,355,818 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01142,474,428 - 42,484,454 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01144,039,665 - 44,049,648 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1144,039,669 - 44,049,648 (-)Ensemblrn6Rnor6.0
Rnor_5.01147,229,581 - 47,239,564 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41142,748,703 - 42,758,686 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1141,735,836 - 41,745,819 (-)NCBICelera
RGSC_v3.11142,807,556 - 42,935,211 (-)NCBI
Cytogenetic Map11q12NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-diaminotoluene  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,6-dinitrotoluene  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3-chloropropane-1,2-diol  (EXP)
3-methylcholanthrene  (ISO)
4,4'-sulfonyldiphenol  (ISO)
5-aminolevulinic acid hexyl ester  (ISO)
6-propyl-2-thiouracil  (EXP)
7,12-dimethyltetraphene  (ISO)
actinomycin D  (ISO)
aflatoxin B1  (ISO)
amitrole  (EXP)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
benzo[a]pyrene  (ISO)
beta-lapachone  (ISO)
beta-naphthoflavone  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
Butylbenzyl phthalate  (ISO)
cadmium dichloride  (ISO)
carbon nanotube  (ISO)
carnosic acid  (ISO)
CGP 52608  (ISO)
chlordecone  (ISO)
chlorpyrifos  (ISO)
cisplatin  (ISO)
clofibrate  (ISO)
copper(II) sulfate  (ISO)
coproporphyrinogen III  (ISO)
cyclosporin A  (ISO)
Dibutyl phosphate  (ISO)
dicyclanil  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
enzyme inhibitor  (ISO)
epoxiconazole  (ISO)
ethanol  (ISO)
ferroheme b  (ISO)
finasteride  (EXP)
fluoranthene  (ISO)
flutamide  (EXP)
folic acid  (ISO)
fulvestrant  (ISO)
gentamycin  (EXP)
heme b  (ISO)
hyaluronic acid  (EXP)
hydrogen peroxide  (EXP)
Isocoproporphyrin  (ISO)
ivermectin  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
mercury atom  (ISO)
mercury(0)  (ISO)
Mesaconitine  (EXP)
methapyrilene  (EXP)
nefazodone  (EXP)
nitrofen  (EXP)
Nutlin-3  (ISO)
oxaliplatin  (EXP)
paracetamol  (EXP,ISO)
phenobarbital  (ISO)
pirinixic acid  (ISO)
propiconazole  (ISO)
protoporphyrinogen  (ISO)
SB 431542  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (EXP)
sodium fluoride  (ISO)
sulfadimethoxine  (EXP)
sunitinib  (ISO)
temozolomide  (ISO)
testosterone  (ISO)
thapsigargin  (EXP)
titanium dioxide  (ISO)
topotecan  (EXP)
trimellitic anhydride  (ISO)
triphenyl phosphate  (ISO)
trovafloxacin  (EXP)
valproic acid  (ISO)
vinclozolin  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Effects of iron deficiency and chronic iron overloading on mitochondrial heme biosynthetic enzymes in rat liver. Abraham NG, etal., Biochim Biophys Acta. 1986 Mar 28;870(2):339-49.
2. Decreased activity of liver coproporphyrinogen oxidase in hexachlorobenzene-induced porphyria. Adjarov DG, Exp Pathol. 1990;40(2):117-22. doi: 10.1016/s0232-1513(11)80331-2.
3. Biosynthesis of heme in mammals. Ajioka RS, etal., Biochim Biophys Acta. 2006 Jul;1763(7):723-36. Epub 2006 Jun 3.
4. Synthesis, delivery and regulation of eukaryotic heme and Fe-S cluster cofactors. Barupala DP, etal., Arch Biochem Biophys. 2016 Feb 15;592:60-75. doi: 10.1016/j.abb.2016.01.010. Epub 2016 Jan 16.
5. The mitochondrial location of protoporphyrinogen oxidase. Deybach JC, etal., Eur J Biochem. 1985 Jun 3;149(2):431-5.
6. Characterization and expression of cDNA encoding coproporphyrinogen oxidase from a patient with hereditary coproporphyria. Fujita H, etal., Hum Mol Genet. 1994 Oct;3(10):1807-10.
7. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
8. GenMAPP: Gene Map Annotator and Pathway Profiler GenMAPP
9. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
10. Hepatic drug metabolism and haem biosynthesis in lead-poisoned rats. Goldberg A, etal., Br J Pharmacol. 1978 Apr;62(4):529-36.
11. The mitochondrial localization of coproporphyrinogen III oxidase. Grandchamp B, etal., Biochem J. 1978 Oct 15;176(1):97-102.
12. A high-performance-liquid-chromatographic method for the assay of coproporphyrinogen oxidase activity in rat liver. Li F, etal., Biochem J. 1986 Oct 15;239(2):481-4.
13. Coproporphyrinogen oxidase, protoporphyrinogen oxidase and ferrochelatase activities in iron-overloaded and ethanol-treated rats. Li F, etal., Biomed Chromatogr. 1990 Nov;4(6):253-6.
14. Acute hepatic porphyrias: Identification of 46 hydroxymethylbilane synthase, 11 coproporphyrinogen oxidase, and 20 protoporphyrinogen oxidase novel mutations. Loskove Y, etal., Mol Genet Metab. 2019 Nov;128(3):352-357. doi: 10.1016/j.ymgme.2018.10.008. Epub 2018 Oct 26.
15. The site of inhibition of porphyrin biosynthesis by an isomer of diazinon in rats. Nichol AW, etal., Biochem Pharmacol. 1983 Sep 15;32(18):2653-7.
16. Harderoporphyria: a variant hereditary coproporphyria. Nordmann Y, etal., J Clin Invest. 1983 Sep;72(3):1139-49. doi: 10.1172/JCI111039.
17. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
18. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
19. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
20. GOA pipeline RGD automated data pipeline
21. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
22. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
23. Systematic analysis of coproporphyrinogen oxidase gene defects in hereditary coproporphyria and mutation update. Rosipal R, etal., Hum Mutat. 1999;13(1):44-53. doi: 10.1002/(SICI)1098-1004(1999)13:1<44::AID-HUMU5>3.0.CO;2-Q.
24. Hexachlorobenzene treatment on hepatic mitochondrial function parameters and intracellular coproporphyrinogen oxidase location. Sopena YE, etal., Int J Toxicol. 2008 Nov;27(6):455-65.
25. Function and structure of rat hepatic coproporphyrinogen oxidase. Sorianello EM and Mazzetti MB, Comp Biochem Physiol B Biochem Mol Biol. 2000 Oct;127(2):155-64.
26. Biochemical and genetic characterization of four cases of hereditary coproporphyria in Spain. To-Figueras J, etal., Mol Genet Metab. 2005 Jun;85(2):160-3. doi: 10.1016/j.ymgme.2004.12.012. Epub 2005 Feb 25.
27. Liver haem metabolism in adjuvant-induced arthritic rats. Toda A, etal., Xenobiotica. 1996 Apr;26(4):415-23.
28. Two novel mutations and coexistence of the 991C>T and the 1339C>T mutation on a single allele in the coproporphyrinogen oxidase gene in Swedish patients with hereditary coproporphyria. Wiman A, etal., J Hum Genet. 2002;47(8):407-12. doi: 10.1007/s100380200059.
29. Studies on the etiology of trace metal-induced porphyria: effects of porphyrinogenic metals on coproporphyrinogen oxidase in rat liver and kidney. Woods JS and Southern MR, Toxicol Appl Pharmacol. 1989 Jan;97(1):183-90.
Additional References at PubMed
PMID:8407975   PMID:12470976   PMID:12477932   PMID:14651853   PMID:15482256   PMID:16176984   PMID:18614015   PMID:20080761  


Genomics

Comparative Map Data
Cpox
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81155,405,778 - 55,415,761 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1155,405,784 - 55,415,761 (-)EnsemblGRCr8
mRatBN7.21141,936,585 - 41,946,568 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1141,936,591 - 41,946,746 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1150,684,226 - 50,694,252 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01143,345,792 - 43,355,818 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01142,474,428 - 42,484,454 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01144,039,665 - 44,049,648 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1144,039,669 - 44,049,648 (-)Ensemblrn6Rnor6.0
Rnor_5.01147,229,581 - 47,239,564 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41142,748,703 - 42,758,686 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1141,735,836 - 41,745,819 (-)NCBICelera
RGSC_v3.11142,807,556 - 42,935,211 (-)NCBI
Cytogenetic Map11q12NCBI
CPOX
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38398,570,488 - 98,593,611 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl398,579,446 - 98,593,707 (-)Ensemblhg38GRCh38
GRCh37398,298,290 - 98,312,455 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36399,780,980 - 99,795,131 (-)NCBIBuild 36Build 36hg18NCBI36
Build 34399,780,981 - 99,795,131NCBI
Celera396,689,942 - 96,704,107 (-)NCBICelera
Cytogenetic Map3q11.2NCBI
HuRef395,670,419 - 95,684,588 (-)NCBIHuRef
CHM1_1398,261,466 - 98,275,631 (-)NCBICHM1_1
T2T-CHM13v2.03101,272,112 - 101,297,297 (-)NCBIT2T-CHM13v2.0
Cpox
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391658,490,571 - 58,500,754 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1658,490,655 - 58,537,999 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381658,670,208 - 58,680,391 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1658,670,292 - 58,717,636 (+)Ensemblmm10GRCm38
MGSCv371658,670,321 - 58,680,504 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361658,612,835 - 58,622,904 (+)NCBIMGSCv36mm8
Celera1658,961,121 - 58,971,379 (+)NCBICelera
Cytogenetic Map16C1.2NCBI
Cpox
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955427152,894 - 164,030 (-)Ensembl
ChiLan1.0NW_004955427152,397 - 163,570 (-)NCBIChiLan1.0ChiLan1.0
CPOX
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2296,505,625 - 96,529,606 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1396,510,420 - 96,534,386 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0395,674,861 - 95,689,139 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.13102,358,149 - 102,372,323 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl3102,359,382 - 102,372,170 (-)EnsemblpanPan2panpan1.1
CPOX
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1335,446,022 - 5,459,152 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl335,447,414 - 5,459,461 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha335,596,705 - 5,613,382 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0335,579,096 - 5,595,946 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl335,535,265 - 5,595,946 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1335,456,702 - 5,473,645 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0335,519,969 - 5,536,809 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0335,796,805 - 5,813,754 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Cpox
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405602151,514,512 - 151,526,977 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366304,412,273 - 4,425,520 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049366304,412,099 - 4,424,867 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CPOX
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl13160,332,436 - 160,348,232 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.113160,332,436 - 160,345,862 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213170,521,920 - 170,535,349 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CPOX
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12282,252,163 - 82,265,827 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2282,251,972 - 82,267,350 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604184,286,976 - 84,301,373 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cpox
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462478911,435,779 - 11,448,984 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462478911,435,955 - 11,448,867 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Cpox
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1442,638,764 - 42,648,675 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Cpox
34 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:151
Count of miRNA genes:122
Interacting mature miRNAs:139
Transcripts:ENSRNOT00000002257
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300147Bp187Blood pressure QTL 1873.67arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)112252474682951192Rat
1598841Memor7Memory QTL 7exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)113330600878306008Rat
724554Iddm17Insulin dependent diabetes mellitus QTL 170.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)114644316891443168Rat
1598811Bp291Blood pressure QTL 2911.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)113330600878306008Rat
11528648Bss118Bone structure and strength QTL 1186.6582e-07femur strength trait (VT:0010010)femur ultimate displacement (CMO:0002719)115410798756845449Rat
634339Niddm50Non-insulin dependent diabetes mellitus QTL 503.32blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)111080612555806125Rat
634341Bw121Body weight QTL 1213.56abdominal fat pad mass (VT:1000711)abdominal fat pad weight (CMO:0000088)113532319955805892Rat
8694376Bw156Body weight QTL 1562.250.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)113674945981749459Rat
10755497Bp388Blood pressure QTL 3882.76arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)113294306789836615Rat
724517Uae18Urinary albumin excretion QTL 183.7urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)112995899657754989Rat
2290451Scl58Serum cholesterol level QTL 583.48blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)112631803155806125Rat
1300130Rf20Renal function QTL 204.44kidney glomerulus integrity trait (VT:0010546)kidney glomerulus diameter (CMO:0001166)113191546976915469Rat
10058952Gmadr6Adrenal mass QTL 62.290.0072adrenal gland mass (VT:0010420)both adrenal glands wet weight to body weight ratio (CMO:0002411)113642841681428416Rat
1600394Edcs1Endometrial carcinoma susceptibility QTL12.90.04uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)111282315257823152Rat
1558659Tescar1Testicular tumor resistance QTL 13.9testis integrity trait (VT:0010572)percentage of study population developing testis tumors during a period of time (CMO:0001261)113461876079618760Rat
1300135Rf19Renal function QTL 193.38blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)115441539196071021Rat
724563Uae10Urinary albumin excretion QTL 106urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)112019354996351019Rat
9589032Epfw10Epididymal fat weight QTL 109.290.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)113674945981749459Rat
9590313Scort20Serum corticosterone level QTL 206.510.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)113674945981749459Rat
8694424Bw162Body weight QTL 1623.80.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)113674945981749459Rat
1300110Stl7Serum triglyceride level QTL 74.64blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)115107102196071021Rat
631510Spl2Serum phospholipid level QTL 24.1blood phospholipid amount (VT:0006084)serum phospholipid level (CMO:0001171)112755668572556685Rat

Markers in Region
RH131349  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21141,936,652 - 41,936,815 (+)MAPPERmRatBN7.2
Rnor_6.01144,039,733 - 44,039,895NCBIRnor6.0
Rnor_5.01147,229,649 - 47,229,811UniSTSRnor5.0
RGSC_v3.41142,748,771 - 42,748,933UniSTSRGSC3.4
Celera1141,735,904 - 41,736,066UniSTS
Cytogenetic Map11q12UniSTS
AI071090  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21141,937,495 - 41,937,679 (+)MAPPERmRatBN7.2
Rnor_6.01144,040,576 - 44,040,759NCBIRnor6.0
Rnor_5.01147,230,492 - 47,230,675UniSTSRnor5.0
RGSC_v3.41142,749,614 - 42,749,797UniSTSRGSC3.4
Celera1141,736,747 - 41,736,930UniSTS
RH 3.4 Map11304.6UniSTS
Cytogenetic Map11q12UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 164 91 90 59 92 59 6 356 192 11 143 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000002257   ⟹   ENSRNOP00000002257
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1155,405,784 - 55,415,761 (-)Ensembl
mRatBN7.2 Ensembl1141,936,591 - 41,946,746 (-)Ensembl
Rnor_6.0 Ensembl1144,039,669 - 44,049,648 (-)Ensembl
RefSeq Acc Id: NM_001037095   ⟹   NP_001032172
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81155,405,778 - 55,415,761 (-)NCBI
mRatBN7.21141,936,585 - 41,946,568 (-)NCBI
Rnor_6.01144,039,665 - 44,049,648 (-)NCBI
Rnor_5.01147,229,581 - 47,239,564 (-)NCBI
RGSC_v3.41142,748,703 - 42,758,686 (-)RGD
Celera1141,735,836 - 41,745,819 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001032172 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAI07665 (Get FASTA)   NCBI Sequence Viewer  
  EDM11016 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000002257
GenBank Protein Q3B7D0 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001032172   ⟸   NM_001037095
- Peptide Label: precursor
- UniProtKB: Q3B7D0 (UniProtKB/Swiss-Prot),   A0A8L2UHB5 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000002257   ⟸   ENSRNOT00000002257

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q3B7D0-F1-model_v2 AlphaFold Q3B7D0 1-443 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13698105
Promoter ID:EPDNEW_R8630
Type:initiation region
Name:Cpox_1
Description:coproporphyrinogen oxidase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01144,049,686 - 44,049,746EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1311817 AgrOrtholog
BioCyc Gene G2FUF-21570 BioCyc
Ensembl Genes ENSRNOG00000001654 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000002257 ENTREZGENE
Gene3D-CATH 3.40.1500.10 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7936479 IMAGE-MGC_LOAD
InterPro Coprogen_oxidase_aer UniProtKB/Swiss-Prot
  Coprogen_oxidase_aer_sf UniProtKB/Swiss-Prot
  Coprogen_oxidase_CS UniProtKB/Swiss-Prot
KEGG Report rno:304024 UniProtKB/Swiss-Prot
MGC_CLONE MGC:124847 IMAGE-MGC_LOAD
NCBI Gene 304024 ENTREZGENE
PANTHER OXYGEN-DEPENDENT COPROPORPHYRINOGEN-III OXIDASE, MITOCHONDRIAL UniProtKB/Swiss-Prot
  PTHR10755 UniProtKB/Swiss-Prot
Pfam Coprogen_oxidas UniProtKB/Swiss-Prot
PhenoGen Cpox PhenoGen
PRINTS COPRGNOXDASE UniProtKB/Swiss-Prot
PROSITE COPROGEN_OXIDASE UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000001654 RatGTEx
Superfamily-SCOP SSF102886 UniProtKB/Swiss-Prot
UniProt A0A8L2UHB5 ENTREZGENE, UniProtKB/TrEMBL
  A6IQL3_RAT UniProtKB/TrEMBL
  HEM6_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2005-12-06 Cpox  coproporphyrinogen oxidase  Cpox_predicted  coproporphyrinogen oxidase (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Cpox_predicted  coproporphyrinogen oxidase (predicted)      Symbol and Name status set to approved 70820 APPROVED